| Monday, January 13 |
| Former Indian Mike Garcia dies in Fairview Park, OH at the age of 63. |
| Tuesday, February 25 |
| Former Indian George Susce dies in Sarasota, FL at the age of 79. |
| Monday, April 7 |
| » Defeated Orioles (0-1), 6-4 | Memorial Stadium (1-0) | 1-0 | |
| » W: Ken Schrom (1-0) L: Mike Flanagan (0-1) S: Ernie Camacho (1) | First | -- |
| » Major-league debuts: Andy Allanson (Indians) |
| Wednesday, April 9 |
| » Lost to Orioles (1-1), 4-3 | Memorial Stadium (1-1) | 1-1 | |
| » W: Don Aase (1-0) L: Scott Bailes (0-1) | Second | 1 out |
| » Major-league debuts: Scott Bailes (Indians) |
| Thursday, April 10 |
| » Lost to Orioles (2-1), 5-1 | Memorial Stadium (1-2) | 1-2 | Lost 2 |
| » W: Ken Dixon (1-0) L: Jim Kern (0-1) S: Rich Bordi (1) | Third | 2 out |
| Friday, April 11 |
| » Lost to Tigers (3-1), 7-2 | Cleveland Stadium (0-1) | 1-3 | Lost 3 |
| » W: Walt Terrell (1-0) L: Phil Niekro (0-1) | Third | 2 out |
| Saturday, April 12 |
| » Defeated Tigers (3-2), 6-2 | Cleveland Stadium (1-1) | 2-3 | |
| » W: Ken Schrom (2-0) L: Jack Morris (1-1) S: Ernie Camacho (2) | Third | 2 out |
| Sunday, April 13 |
| » Defeated Tigers (3-3), 8-2 | Cleveland Stadium (2-1) | 3-3 | Won 2 |
| » W: Scott Bailes (1-1) L: Frank Tanana (0-1) | Second | 2 out |
| Tuesday, April 15 |
| » Lost to Yankees (6-1), 6-2 | Cleveland Stadium (2-2) | 3-4 | |
| » W: Joe Niekro (1-0) L: Tom Candiotti (0-1) S: Brian Fisher (1) | Third | 3 out |
| Thursday, April 17 |
| » Defeated Yankees (6-2), 6-4 | Cleveland Stadium (3-2) | 4-4 | |
| » W: Phil Niekro (1-1) L: Bob Tewksbury (1-1) S: Scott Bailes (1) | Third | 2 out |
| Friday, April 18 |
| » Lost to Tigers (6-4), 6-1 | Tiger Stadium (0-1) | 4-5 | |
| » W: Frank Tanana (1-1) L: Ken Schrom (2-1) | Fourth | 2 out |
| » Major-league debuts: Eddie Williams (Indians) |
| Saturday, April 19 |
| » Defeated Tigers (6-5), 8-6 | Tiger Stadium (1-1) | 5-5 | |
| » W: Scott Bailes (2-1) L: Dan Petry (1-2) S: Ernie Camacho (3) | Third | 1 out |
| Monday, April 21 |
| » Defeated Orioles (7-6), 7-0 | Cleveland Stadium (4-2) | 6-5 | Won 2 |
| » W: Tom Candiotti (1-1) L: Mike Flanagan (1-2) | Third | 1½ out |
| Tuesday, April 22 |
| » Lost to Orioles (8-6), 5-2 | Cleveland Stadium (4-3) | 6-6 | |
| » W: Ken Dixon (2-0) L: Phil Niekro (1-2) S: Don Aase (4) | Fourth | 2½ out |
| Wednesday, April 23 |
| » Defeated Orioles (8-7), 5-1 | Cleveland Stadium (5-3) | 7-6 | |
| » W: Ken Schrom (3-1) L: Scott McGregor (1-2) S: Scott Bailes (2) | Third | 2½ out |
| Thursday, April 24 |
| » Lost to Yankees (11-4), 2-1 | Yankee Stadium (0-1) | 7-7 | |
| » W: Ron Guidry (3-0) L: Neal Heaton (0-1) | Fourth | 3½ out |
| Friday, April 25 |
| » Lost to Yankees (12-4), 10-3 | Yankee Stadium (0-2) | 7-8 | Lost 2 |
| » W: Joe Niekro (2-0) L: Tom Candiotti (1-2) S: Dave Righetti (5) | Fourth | 4½ out |
| Saturday, April 26 |
| » Defeated Yankees (12-5), 3-2 | Yankee Stadium (1-2) | 8-8 | |
| » W: Don Schulze (1-0) L: Bob Shirley (0-1) S: Ernie Camacho (4) | Third | 3½ out |
| » Major-league debuts: Phil Lombardi (Yankees) |
| Sunday, April 27 |
| » Defeated Yankees (12-6), 9-7 | Yankee Stadium (2-2) | 9-8 | Won 2 |
| » W: Scott Bailes (3-1) L: Dave Righetti (2-1) S: Rich Yett (1) | Second | 2½ out |
| Monday, April 28 |
| Former Indian Pat Seerey dies in Jennings, MO at the age of 64. |
| Tuesday, April 29 |
| » Defeated Rangers (9-9), 6-5 | Arlington Stadium (1-0) | 10-8 | Won 3 |
| » W: Jim Kern (1-1) L: Greg Harris (2-3) S: Ernie Camacho (5) | Second | 2½ out |
| Wednesday, April 30 |
| » Defeated Rangers (9-10), 6-4 | Arlington Stadium (2-0) | 11-8 | Won 4 |
| » W: Don Schulze (2-0) L: Jose Guzman (1-4) S: Ernie Camacho (6) | Second | 2½ out |
| Friday, May 2 |
| » Defeated White Sox (7-13), 7-5 | Comiskey Park I (1-0) | 12-8 | Won 5 |
| » W: Ernie Camacho (1-0) L: Dave J. Schmidt (0-1) | Second | 1 out |
| Saturday, May 3 |
| » Defeated White Sox (7-14), 8-7 | Comiskey Park I (2-0) | 13-8 | Won 6 |
| » W: Rich Yett (1-0) L: Bill Dawley (0-1) | Second | 1 out |
| Sunday, May 4 |
| » Defeated White Sox (7-15), 6-4 | Comiskey Park I (3-0) | 14-8 | Won 7 |
| » W: Scott Bailes (4-1) L: Bob James (1-2) | First | -- |
| Monday, May 5 |
| » Defeated Royals (11-12), 5-4 | Cleveland Stadium (6-3) | 15-8 | Won 8 |
| » W: Phil Niekro (2-2) L: Dan Quisenberry (0-1) | First | -- |
| Tuesday, May 6 |
| » Defeated Royals (11-13), 6-1 | Cleveland Stadium (7-3) | 16-8 | Won 9 |
| » W: Tom Candiotti (2-2) L: Buddy Black (1-3) | First | -- |
| Wednesday, May 7 |
| » Defeated Royals (11-14), 7-1 | Cleveland Stadium (8-3) | 17-8 | Won 10 |
| » W: Neal Heaton (1-1) L: Bret Saberhagen (2-3) | First | -- |
| Friday, May 9 |
| » Lost to White Sox (8-18), 4-3 | Cleveland Stadium (8-4) | 17-9 | |
| » W: Gene Nelson (2-1) L: Scott Bailes (4-2) | Second | ½ out |
| Saturday, May 10 |
| » Lost to White Sox (9-18), 4-0 | Cleveland Stadium (8-5) | 17-10 | Lost 2 |
| » W: Gene Nelson (3-1) L: Scott Bailes (4-3) | Third | 1½ out |
| Sunday, May 11 |
| » Lost to White Sox (10-18), 5-4 | Cleveland Stadium (8-6) | 17-11 | Lost 3 |
| » W: Joel McKeon (1-0) L: Tom Candiotti (2-3) S: Bob James (5) | Third | 2 out |
| Monday, May 12 |
| » Lost to Rangers (16-13), 19-2 | Cleveland Stadium (8-7) | 17-12 | Lost 4 |
| » W: Charlie Hough (2-0) L: Neal Heaton (1-2) S: Mickey Mahler (2) | Second | 2 out |
| Tuesday, May 13 |
| » Defeated Rangers (16-14), 3-2 | Cleveland Stadium (9-7) | 18-12 | |
| » W: Rich Yett (2-0) L: Greg Harris (2-5) | Third | 2 out |
| Wednesday, May 14 |
| » Lost to Royals (15-16), 5-0 | Royals Stadium (0-1) | 18-13 | |
| » W: Mark Gubicza (1-4) L: Phil Niekro (2-3) | Second | 2 out |
| Thursday, May 15 |
| » Lost to Royals (16-16), 6-3 | Royals Stadium (0-2) | 18-14 | Lost 2 |
| » W: Dennis Leonard (4-3) L: Scott Bailes (4-4) S: Buddy Black (1) | Third | 2½ out |
| Friday, May 16 |
| » Lost to Blue Jays (15-20), 7-6 | Exhibition Stadium (0-1) | 18-15 | Lost 3 |
| » W: Jim Acker (1-2) L: Tom Candiotti (2-4) S: Mark Eichhorn (3) | Third | 2½ out |
| Saturday, May 17 |
| » Lost to Blue Jays (16-20), 11-5 | Exhibition Stadium (0-2) | 18-16 | Lost 4 |
| » W: Jimmy Key (2-3) L: Neal Heaton (1-3) | Fourth | 3½ out |
| » Major-league debuts: Fred McGriff (Blue Jays) Reggie Ritter (Indians) |
| Sunday, May 18 |
| » Lost to Blue Jays (17-20), 10-2 | Exhibition Stadium (0-3) | 18-17 | Lost 5 |
| » W: Jim Clancy (4-2) L: Don Schulze (2-1) | Fifth | 4½ out |
| Monday, May 19 |
| » Defeated Blue Jays (17-21), 6-4 | Exhibition Stadium (1-3) | 19-17 | |
| » W: Phil Niekro (3-3) L: Dave Stieb (0-6) S: Scott Bailes (3) | Fifth | 4½ out |
| Tuesday, May 20 |
| » Lost to Brewers (20-16), 12-9 | County Stadium (0-1) | 19-18 | |
| » W: Dan Plesac (3-1) L: Jamie Easterly (0-1) | Fourth | 5½ out |
| Wednesday, May 21 |
| » Defeated Brewers (20-17), 4-2 | County Stadium (1-1) | 20-18 | |
| » W: Tom Candiotti (3-4) L: Bill Wegman (0-4) | Fifth | 5½ out |
| Thursday, May 22 |
| » Defeated Brewers (20-18), 5-4 | County Stadium (2-1) | 21-18 | Won 2 |
| » W: Neal Heaton (2-3) L: Teddy Higuera (5-4) S: Scott Bailes (4) | Fourth | 5 out |
| Friday, May 23 |
| » Defeated Blue Jays (18-24), 3-1 | Cleveland Stadium (10-7) | 22-18 | Won 3 |
| » W: Don Schulze (3-1) L: Jim Clancy (4-3) | Fourth | 5 out |
| Saturday, May 24 |
| » Lost to Blue Jays (19-24), 9-6 | Cleveland Stadium (10-8) | 22-19 | |
| » W: Dennis Lamp (1-3) L: Jamie Easterly (0-2) S: Mark Eichhorn (4) | Fourth | 5 out |
| Sunday, May 25 |
| » Lost to Blue Jays (20-24), 8-1 | Cleveland Stadium (10-9) | 22-20 | Lost 2 |
| » W: John Cerutti (1-1) L: Ken Schrom (3-2) | Fourth | 6 out |
| Monday, May 26 |
| » Lost to Red Sox (29-14), 5-3 | Cleveland Stadium (10-10) | 22-21 | Lost 3 |
| » W: Bruce Hurst (4-3) L: Tom Candiotti (3-5) S: Bob Stanley (8) | Fifth | 7 out |
| Tuesday, May 27 |
| » Lost to Red Sox (30-14), 2-0 | Cleveland Stadium (10-11) | 22-22 | Lost 4 |
| » W: Mike Brown (3-1) L: Neal Heaton (2-4) S: Steve Crawford (1) | Sixth | 8 out |
| Wednesday, May 28 |
| » Lost to Red Sox (31-14), 13-7 | Cleveland Stadium (10-12) | 22-23 | Lost 5 |
| » W: Oil Can Boyd (6-3) L: Don Schulze (3-2) | Sixth | 9 out |
| Friday, May 30 |
| » Lost to Brewers (24-21), 11-7 | Cleveland Stadium (10-13) | 22-24 | Lost 6 |
| » W: Juan Nieves (5-1) L: Phil Niekro (3-4) S: Mark Clear (3) | Sixth | 9 out |
| Saturday, May 31 |
| » Defeated Brewers (24-22), 3-2 | Cleveland Stadium (11-13) | 23-24 | |
| » W: Scott Bailes (5-4) L: Dan Plesac (3-3) | Sixth | 9 out |
| Sunday, June 1 |
| » Defeated Brewers (24-23), 9-7 | Cleveland Stadium (12-13) | 24-24 | Won 2 |
| » W: Scott Bailes (6-4) L: Bob McClure (2-1) S: Ernie Camacho (7) | Sixth | 9 out |
| Monday, June 2 |
| » Lost to Red Sox (34-15), 3-1 | Fenway Park (0-1) | 24-25 | |
| » W: Oil Can Boyd (7-3) L: Neal Heaton (2-5) S: Steve Crawford (2) | Fifth | 10 out |
| Tuesday, June 3 |
| » Lost to Red Sox (35-15), 5-1 | Fenway Park (0-2) | 24-26 | Lost 2 |
| » W: Mike Brown (4-1) L: Don Schulze (3-3) | Sixth | 11 out |
| Wednesday, June 4 |
| » Lost to Red Sox (36-15), 6-4 | Fenway Park (0-3) | 24-27 | Lost 3 |
| » W: Rob Woodward (1-1) L: Phil Niekro (3-5) S: Bob Stanley (9) | Seventh | 12 out |
| Friday, June 6 |
| » Defeated Angels (26-27), 3-0 | Cleveland Stadium (13-13) | 25-27 | |
| » W: Ken Schrom (4-2) L: Kirk McCaskill (4-4) | Fifth | 11½ out |
| Saturday, June 7 |
| » Lost to Angels (27-27), 8-2 | Cleveland Stadium (13-14) | 25-28 | |
| » W: Mike Witt (6-4) L: Tom Candiotti (3-6) | Seventh | 11½ out |
| Sunday, June 8 |
| » Defeated Angels (27-28), 11-4 | Cleveland Stadium (14-14) | 26-28 | |
| » W: Neal Heaton (3-5) L: Jim Slaton (4-5) | Seventh | 10½ out |
| Monday, June 9 |
| » Defeated Athletics (25-33), 6-5 | Cleveland Stadium (15-14) | 27-28 | Won 2 |
| » W: Scott Bailes (7-4) L: Jose Rijo (2-3) | Fifth | 9½ out |
| Tuesday, June 10 |
| » Defeated Athletics (25-34), 8-7 | Cleveland Stadium (16-14) | 28-28 | Won 3 |
| » W: Rich Yett (3-0) L: Jose Rijo (2-4) | Fifth | 9½ out |
| Wednesday, June 11 |
| » Defeated Athletics (25-35), 7-4 | Cleveland Stadium (17-14) | 29-28 | Won 4 |
| » W: Ken Schrom (5-2) L: Rick Langford (1-6) S: Scott Bailes (5) | Fifth | 9½ out |
| Friday, June 13 |
| » Defeated Twins (23-37), 11-2 | Cleveland Stadium (18-14) | 30-28 | Won 5 |
| » W: Tom Candiotti (4-6) L: Bert Blyleven (5-6) | Fourth | 9½ out |
| » Major-league debuts: Cory Snyder (Indians) |
| Saturday, June 14 |
| » Lost to Twins (24-37), 9-3 | Cleveland Stadium (18-15) | 30-29 | |
| » W: Keith Atherton (4-3) L: Neal Heaton (3-6) | Fifth | 9½ out |
| Sunday, June 15 |
| » Lost to Twins (25-37), 7-3 | Cleveland Stadium (18-16) | 30-30 | Lost 2 |
| » W: Frank Viola (6-5) L: Don Schulze (3-4) S: Frank Pastore (2) | Fifth | 9½ out |
| Tuesday, June 17 |
| » Lost to Mariners (26-39), 5-2 | Cleveland Stadium (18-17) | 30-31 | Lost 3 |
| » W: Mike Morgan (5-6) L: Phil Niekro (3-6) | Sixth | 11 out |
| Wednesday, June 18 |
| » Defeated Mariners (26-40), 5-1 | Cleveland Stadium (19-17) | 31-31 | |
| » W: Ken Schrom (6-2) L: Jim Beattie (0-1) S: Scott Bailes (6) | Fifth | 11 out |
| Thursday, June 19 |
| » Defeated Mariners (26-41), 8-1 | Cleveland Stadium (20-17) | 32-31 | Won 2 |
| » W: Tom Candiotti (5-6) L: Mike Moore (3-7) | Fifth | 10½ out |
| Friday, June 20 |
| » Lost to Twins (28-38), 9-8 | Hubert H. Humphrey Metrodome (0-1) | 32-32 | |
| » W: Frank Viola (7-5) L: Dickie Noles (0-1) S: Keith Atherton (2) | Fifth | 10½ out |
| » Major-league debuts: Mark Davidson (Twins) |
| Saturday, June 21 |
| » Defeated Twins (28-39), 7-5 | Hubert H. Humphrey Metrodome (1-1) | 33-32 | |
| » W: Don Schulze (4-4) L: Mark Portugal (2-7) S: Ernie Camacho (8) | Fifth | 10½ out |
| Sunday, June 22 |
| » Defeated Twins (28-40), 4-1 | Hubert H. Humphrey Metrodome (2-1) | 34-32 | Won 2 |
| » W: Phil Niekro (4-6) L: Mike Smithson (6-6) | Fifth | 9½ out |
| Monday, June 23 |
| » Defeated Mariners (27-44), 8-6 | Kingdome (1-0) | 35-32 | Won 3 |
| » W: Ken Schrom (7-2) L: Jim Beattie (0-2) S: Ernie Camacho (9) | Fifth | 8½ out |
| Tuesday, June 24 |
| » Lost to Mariners (28-44), 8-7 | Kingdome (1-1) | 35-33 | |
| » W: Matt Young (6-4) L: Ernie Camacho (1-1) | Fifth | 8½ out |
| Wednesday, June 25 |
| » Lost to Mariners (29-44), 6-1 | Kingdome (1-2) | 35-34 | Lost 2 |
| » W: Mark Langston (8-5) L: John Butcher (0-4) | Sixth | 9½ out |
| Friday, June 27 |
| » Defeated Angels (39-33), 6-3 | Anaheim Stadium (1-0) | 36-34 | |
| » W: Dickie Noles (1-1) L: Mike Witt (8-6) S: Ernie Camacho (10) | Fifth | 9½ out |
| Saturday, June 28 |
| » Lost to Angels (40-33), 9-3 | Anaheim Stadium (1-1) | 36-35 | |
| » W: Doug Corbett (2-1) L: John Butcher (0-5) | Fifth | 10½ out |
| Sunday, June 29 |
| » Defeated Angels (40-34), 6-4 | Anaheim Stadium (2-1) | 37-35 | |
| » W: Ken Schrom (8-2) L: Ron Romanick (5-6) S: Ernie Camacho (11) | Fifth | 10½ out |
| Monday, June 30 |
| » Defeated Athletics (30-48), 8-3 | Oakland-Alameda County Stadium (1-0) | 38-35 | Won 2 |
| » W: Tom Candiotti (6-6) L: Jose Rijo (2-7) | Fourth | 10½ out |
| Tuesday, July 1 |
| » Defeated Athletics (30-49), 9-0 | Oakland-Alameda County Stadium (2-0) | 39-35 | Won 3 |
| » W: John Butcher (1-5) L: Rick Langford (1-9) | Fourth | 10½ out |
| Wednesday, July 2 |
| » Defeated Athletics (30-50), 7-3 | Oakland-Alameda County Stadium (3-0) | 40-35 | Won 4 |
| » W: Dickie Noles (2-1) L: Bill Mooneyham (2-3) S: Scott Bailes (7) | Third | 9½ out |
| Friday, July 4 |
| » Defeated Royals (37-42), 10-3 | Cleveland Stadium (21-17) | 41-35 | Won 5 |
| » W: Phil Niekro (5-6) L: Danny Jackson (4-6) | Third | 9 out |
| Saturday, July 5 |
| » Defeated Royals (37-43), 10-5 | Cleveland Stadium (22-17) | 42-35 | Won 6 |
| » W: Ken Schrom (9-2) L: Bret Saberhagen (4-10) | Third | 8 out |
| Sunday, July 6 |
| » Defeated Royals (37-44), 5-0 | Cleveland Stadium (23-17) | 43-35 | Won 7 |
| » W: Tom Candiotti (7-6) L: Dennis Leonard (6-8) | Second | 8 out |
| Monday, July 7 |
| » Lost to White Sox (37-43), 4-3 | Comiskey Park I (3-1) | 43-36 | |
| » W: Bob James (4-4) L: Ernie Camacho (1-2) | Third | 8 out |
| Tuesday, July 8 |
| » Lost to White Sox (38-43), 6-2 | Comiskey Park I (3-2) | 43-37 | Lost 2 |
| » W: Neil Allen (5-1) L: Bryan Oelkers (0-1) S: Dave J. Schmidt (4) | Third | 9 out |
| Former Indian Skeeter Webb dies in Meridian, MS at the age of 77. |
| Wednesday, July 9 |
| » Defeated White Sox (38-44), 6-3 | Comiskey Park I (4-2) | 44-37 | |
| » W: Phil Niekro (6-6) L: Richard Dotson (7-8) | Third | 9 out |
| Thursday, July 10 |
| » Defeated Rangers (45-40), 9-6 | Cleveland Stadium (24-17) | 45-37 | Won 2 |
| » W: Ken Schrom (10-2) L: Ed Correa (6-7) S: Ernie Camacho (12) | Third | 9 out |
| Friday, July 11 |
| » Defeated Rangers (45-41), 7-2 | Cleveland Stadium (25-17) | 46-37 | Won 3 |
| » W: Tom Candiotti (8-6) L: Bobby Witt (4-8) | Third | 8 out |
| Saturday, July 12 |
| » Lost to Rangers (46-41), 11-6 | Cleveland Stadium (25-18) | 46-38 | |
| » W: Charlie Hough (9-4) L: John Butcher (1-6) | Third | 9 out |
| Sunday, July 13 |
| » Lost to Rangers (47-41), 5-3 | Cleveland Stadium (25-19) | 46-39 | Lost 2 |
| » W: Mitch Williams (7-1) L: Scott Bailes (7-5) | Third | 9 out |
| Thursday, July 17 |
| » Lost to Royals (41-48), 5-1 | Royals Stadium (0-3) | 46-40 | Lost 3 |
| » W: Bret Saberhagen (5-10) L: Tom Candiotti (8-7) | Third | 9 out |
| Friday, July 18 |
| » Defeated Royals (41-49), 3-2 | Royals Stadium (1-3) | 47-40 | |
| » W: Bryan Oelkers (1-1) L: Dan Quisenberry (0-4) | Third | 8 out |
| Saturday, July 19 |
| » Defeated Royals (41-50), 6-4 | Royals Stadium (2-3) | 48-40 | Won 2 |
| » W: Phil Niekro (7-6) L: Scott Bankhead (3-4) S: Ernie Camacho (13) | Third | 8 out |
| Sunday, July 20 |
| » Lost to Royals (42-50), 3-2 | Royals Stadium (2-4) | 48-41 | |
| » W: Steve Farr (7-1) L: Dickie Noles (2-2) | Third | 8 out |
| Monday, July 21 |
| » Defeated White Sox (42-49), 5-2 | Cleveland Stadium (26-19) | 49-41 | |
| » W: Rich Yett (4-0) L: Joel Davis (4-5) | Third | 7 out |
| Tuesday, July 22 |
| » Defeated White Sox (42-50), 8-4 | Cleveland Stadium (27-19) | 50-41 | Won 2 |
| » W: Tom Candiotti (9-7) L: Richard Dotson (7-10) | Third | 6 out |
| Wednesday, July 23 |
| » Defeated White Sox (42-51), 7-2 | Cleveland Stadium (28-19) | 51-41 | Won 3 |
| » W: Ken Schrom (11-2) L: Floyd Bannister (5-7) | Third | 5 out |
| Thursday, July 24 |
| » Lost to Rangers (48-48), 7-3 | Arlington Stadium (2-1) | 51-42 | |
| » W: Mike Loynd (1-0) L: Phil Niekro (7-7) S: Dale Mohorcic (1) | Third | 5½ out |
| » Major-league debuts: Mike Loynd (Rangers) |
| Friday, July 25 |
| » Lost to Rangers (49-48), 7-5 | Arlington Stadium (2-2) | 51-43 | Lost 2 |
| » W: Greg Harris (4-8) L: Scott Bailes (7-6) | Third | 6½ out |
| Saturday, July 26 |
| » Lost to Rangers (50-48), 8-5 | Arlington Stadium (2-3) | 51-44 | Lost 3 |
| » W: Bobby Witt (5-9) L: Rich Yett (4-1) S: Mitch Williams (3) | Fourth | 6½ out |
| Sunday, July 27 |
| » Defeated Rangers (50-49), 8-3 | Arlington Stadium (3-3) | 52-44 | |
| » W: Tom Candiotti (10-7) L: Ed Correa (6-9) | Fourth | 5½ out |
| Monday, July 28 |
| » Lost to Tigers (52-47), 5-1 | Cleveland Stadium (28-20) | 52-45 | |
| » W: Jack Morris (12-6) L: Ken Schrom (11-3) | Fourth | 6½ out |
| Tuesday, July 29 |
| » Lost to Tigers (53-47), 6-3 | Cleveland Stadium (28-21) | 52-46 | Lost 2 |
| » W: Guillermo Hernandez (7-5) L: Bryan Oelkers (1-2) S: Jim Slaton (1) | Fourth | 6½ out |
| Wednesday, July 30 |
| » Lost to Tigers (54-47), 11-3 | Cleveland Stadium (28-22) | 52-47 | Lost 3 |
| » W: Eric King (8-2) L: John Butcher (1-7) | Sixth | 6½ out |
| Thursday, July 31 |
| » Defeated Tigers (54-48), 8-7 | Cleveland Stadium (29-22) | 53-47 | |
| » W: Scott Bailes (8-6) L: Bill Campbell (2-3) | Fifth | 6 out |
| Friday, August 1 |
| » Defeated Yankees (56-47), 4-3 | Cleveland Stadium (30-22) | 54-47 | Won 2 |
| » W: Phil Niekro (8-7) L: Ron Guidry (5-9) S: Ernie Camacho (14) | Sixth | 6½ out |
| » Lost to Yankees (57-47), 5-3 | Cleveland Stadium (30-23) | 54-48 | |
| » W: Brian Fisher (5-5) L: Tom Candiotti (10-8) S: Dave Righetti (24) | Sixth | 6½ out |
| Saturday, August 2 |
| » Defeated Yankees (57-48), 6-5 | Cleveland Stadium (31-23) | 55-48 | |
| » W: Dickie Noles (3-2) L: Dave Righetti (7-5) | Fourth | 5½ out |
| Sunday, August 3 |
| » Lost to Yankees (58-48), 12-8 | Cleveland Stadium (31-24) | 55-49 | |
| » W: Rod Scurry (1-1) L: Phil Niekro (8-8) S: Brian Fisher (5) | Fourth | 6½ out |
| Tuesday, August 5 |
| » Lost to Tigers (56-50), 6-5 | Tiger Stadium (1-2) | 55-50 | Lost 2 |
| » W: Mark Thurmond (4-8) L: Scott Bailes (8-7) S: Bill Campbell (2) | Sixth | 6½ out |
| » Lost to Tigers (57-50), 11-9 | Tiger Stadium (1-3) | 55-51 | Lost 3 |
| » W: Frank Tanana (9-4) L: John Butcher (1-8) S: Randy O'Neal (1) | Sixth | 6½ out |
| Thursday, August 7 |
| » Lost to Tigers (58-50), 15-1 | Tiger Stadium (1-4) | 55-52 | Lost 4 |
| » W: Jack Morris (13-7) L: Phil Niekro (8-9) | Sixth | 8 out |
| » Lost to Tigers (59-50), 6-2 | Tiger Stadium (1-5) | 55-53 | Lost 5 |
| » W: Mark Thurmond (5-8) L: Ken Schrom (11-4) S: Bill Campbell (3) | Sixth | 8 out |
| Friday, August 8 |
| » Defeated Orioles (59-50), 3-0 | Memorial Stadium (2-2) | 56-53 | |
| » W: Tom Candiotti (11-8) L: Mike Boddicker (14-6) S: Ernie Camacho (15) | Sixth | 8 out |
| Saturday, August 9 |
| » Defeated Orioles (59-51), 8-2 | Memorial Stadium (3-2) | 57-53 | Won 2 |
| » W: Jose Roman (1-0) L: Storm Davis (8-9) | Sixth | 8 out |
| Sunday, August 10 |
| » Defeated Orioles (59-52), 6-3 | Memorial Stadium (4-2) | 58-53 | Won 3 |
| » W: Scott Bailes (9-7) L: Ken Dixon (10-9) S: Ernie Camacho (16) | Fifth | 8 out |
| Monday, August 11 |
| » Lost to Yankees (62-52), 6-5 | Yankee Stadium (2-3) | 58-54 | |
| » W: Brian Fisher (7-5) L: Frank Wills (0-1) | Sixth | 8 out |
| Tuesday, August 12 |
| » Lost to Yankees (63-52), 6-4 | Yankee Stadium (2-4) | 58-55 | Lost 2 |
| » W: Tim Stoddard (2-3) L: Rich Yett (4-2) S: Dave Righetti (26) | Sixth | 7½ out |
| Wednesday, August 13 |
| » Lost to Yankees (64-52), 4-0 | Yankee Stadium (2-5) | 58-56 | Lost 3 |
| » W: Tommy John (5-1) L: Tom Candiotti (11-9) S: Dave Righetti (27) | Sixth | 8½ out |
| Thursday, August 14 |
| » Lost to Orioles (62-53), 12-2 | Cleveland Stadium (31-25) | 58-57 | Lost 4 |
| » W: Storm Davis (9-9) L: Jose Roman (1-1) | Sixth | 9½ out |
| Friday, August 15 |
| » Defeated Orioles (62-54), 3-2 | Cleveland Stadium (32-25) | 59-57 | |
| » W: Frank Wills (1-1) L: Don Aase (5-4) S: Ernie Camacho (17) | Sixth | 9½ out |
| Saturday, August 16 |
| » Defeated Orioles (62-55), 2-1 | Cleveland Stadium (33-25) | 60-57 | Won 2 |
| » W: Phil Niekro (9-9) L: Mike Flanagan (6-8) S: Bryan Oelkers (1) | Sixth | 8½ out |
| Sunday, August 17 |
| » Defeated Orioles (62-56), 11-6 | Cleveland Stadium (34-25) | 61-57 | Won 3 |
| » W: Bryan Oelkers (2-2) L: Mike Boddicker (14-7) | Fifth | 8½ out |
| Monday, August 18 |
| » Defeated Brewers (58-60), 10-4 | Cleveland Stadium (35-25) | 62-57 | Won 4 |
| » W: Tom Candiotti (12-9) L: Chris Bosio (0-2) | Fifth | 8½ out |
| Tuesday, August 19 |
| » Lost to Brewers (59-60), 5-3 | Cleveland Stadium (35-26) | 62-58 | |
| » W: Teddy Higuera (16-8) L: Jose Roman (1-2) S: Mark Clear (12) | Sixth | 8½ out |
| Wednesday, August 20 |
| » Lost to Brewers (60-60), 6-3 | Cleveland Stadium (35-27) | 62-59 | Lost 2 |
| » W: Bill Wegman (4-9) L: Scott Bailes (9-8) S: Dan Plesac (10) | Sixth | 9½ out |
| Thursday, August 21 |
| » Lost to Red Sox (72-49), 24-5 | Cleveland Stadium (35-28) | 62-60 | Lost 3 |
| » W: Oil Can Boyd (12-9) L: Greg Swindell (0-1) | Sixth | 10½ out |
| » Major-league debuts: Greg Swindell (Indians) |
| Friday, August 22 |
| » Lost to Red Sox (73-49), 6-3 | Cleveland Stadium (35-29) | 62-61 | Lost 4 |
| » W: Bruce Hurst (8-6) L: Ken Schrom (11-5) S: Calvin Schiraldi (6) | Sixth | 11½ out |
| Saturday, August 23 |
| » Defeated Red Sox (73-50), 5-4 | Cleveland Stadium (36-29) | 63-61 | |
| » W: Ernie Camacho (2-2) L: Bob Stanley (5-5) | Sixth | 10½ out |
| Sunday, August 24 |
| » Defeated Red Sox (73-51), 5-2 | Cleveland Stadium (37-29) | 64-61 | Won 2 |
| » W: Phil Niekro (10-9) L: Al Nipper (8-9) S: Frank Wills (1) | Sixth | 9½ out |
| Tuesday, August 26 |
| » Tied Blue Jays, 6-6 | Cleveland Stadium (37-29) | 64-61 | |
| » Starters: Joe Johnson vs Scott Bailes | Sixth | 9½ out |
| Wednesday, August 27 |
| » Lost to Blue Jays (68-58), 3-2 | Cleveland Stadium (37-30) | 64-62 | |
| » W: Mark Eichhorn (11-4) L: Bryan Oelkers (2-3) S: Tom Henke (18) | Sixth | 10 out |
| » Lost to Blue Jays (69-58), 6-3 | Cleveland Stadium (37-31) | 64-63 | Lost 2 |
| » W: John Cerutti (8-3) L: Frank Wills (1-2) S: Tom Henke (19) | Sixth | 10 out |
| Thursday, August 28 |
| » Lost to Blue Jays (70-58), 9-1 | Cleveland Stadium (37-32) | 64-64 | Lost 3 |
| » W: Jim Clancy (14-7) L: Ken Schrom (11-6) | Seventh | 10½ out |
| Friday, August 29 |
| » Defeated Red Sox (74-54), 7-3 | Fenway Park (1-3) | 65-64 | |
| » W: Tom Candiotti (13-9) L: Tom Seaver (7-11) | Fifth | 9½ out |
| Saturday, August 30 |
| » Lost to Red Sox (75-54), 7-3 | Fenway Park (1-4) | 65-65 | |
| » W: Roger Clemens (20-4) L: Phil Niekro (10-10) | Seventh | 10½ out |
| Sunday, August 31 |
| » Lost to Red Sox (76-54), 4-3 | Fenway Park (1-5) | 65-66 | Lost 2 |
| » W: Calvin Schiraldi (2-1) L: Frank Wills (1-3) | Seventh | 11½ out |
| Monday, September 1 |
| » Lost to Blue Jays (74-58), 5-4 | Exhibition Stadium (1-4) | 65-67 | Lost 3 |
| » W: Tom Henke (9-3) L: Ernie Camacho (2-3) | Seventh | 12½ out |
| Tuesday, September 2 |
| » Defeated Blue Jays (74-59), 9-5 | Exhibition Stadium (2-4) | 66-67 | |
| » W: Ken Schrom (12-6) L: Jim Clancy (14-8) S: Frank Wills (2) | Sixth | 12½ out |
| » Major-league debuts: Jeff Musselman (Blue Jays) |
| Wednesday, September 3 |
| » Lost to Blue Jays (75-59), 3-1 | Exhibition Stadium (2-5) | 66-68 | |
| » W: Dave Stieb (5-10) L: Tom Candiotti (13-10) S: Tom Henke (20) | Sixth | 13½ out |
| » Major-league debuts: Dave Clark (Indians) |
| Thursday, September 4 |
| » Defeated Brewers (64-69), 15-4 | County Stadium (3-1) | 67-68 | |
| » W: Scott Bailes (10-8) L: Tim Leary (9-12) | Sixth | 13 out |
| Friday, September 5 |
| » Defeated Brewers (64-70), 13-5 | County Stadium (4-1) | 68-68 | Won 2 |
| » W: Phil Niekro (11-10) L: Bill Wegman (4-11) | Fifth | 13 out |
| Saturday, September 6 |
| » Defeated Brewers (64-71), 17-9 | County Stadium (5-1) | 69-68 | Won 3 |
| » W: Greg Swindell (1-1) L: Juan Nieves (10-9) | Fifth | 13 out |
| Sunday, September 7 |
| » Lost to Brewers (65-71), 7-2 | County Stadium (5-2) | 69-69 | |
| » W: Pete Vuckovich (1-1) L: Ken Schrom (12-7) S: Dan Plesac (11) | Fifth | 14 out |
| Tuesday, September 9 |
| » Lost to Angels (79-58), 8-1 | Cleveland Stadium (37-33) | 69-70 | Lost 2 |
| » W: Kirk McCaskill (16-7) L: Tom Candiotti (13-11) | Fifth | 15½ out |
| Wednesday, September 10 |
| » Lost to Angels (80-58), 7-6 | Cleveland Stadium (37-34) | 69-71 | Lost 3 |
| » W: Chuck Finley (2-0) L: Rich Yett (4-3) | Fifth | 16½ out |
| » Major-league debuts: Willie Fraser (Angels) |
| Friday, September 12 |
| » Defeated Athletics (67-75), 9-3 | Cleveland Stadium (38-34) | 70-71 | |
| » W: Greg Swindell (2-1) L: Bill Krueger (1-2) | Fifth | 16 out |
| » Major-league debuts: Terry Steinbach (Athletics) |
| Saturday, September 13 |
| » Defeated Athletics (67-76), 8-6 | Cleveland Stadium (39-34) | 71-71 | Won 2 |
| » W: Bryan Oelkers (3-3) L: Bill Mooneyham (4-5) S: Frank Wills (3) | Fifth | 15 out |
| Sunday, September 14 |
| » Defeated Athletics (67-77), 5-2 | Cleveland Stadium (40-34) | 72-71 | Won 3 |
| » W: Ken Schrom (13-7) L: Jose Rijo (7-11) S: Doug Jones (1) | Fourth | 14 out |
| Monday, September 15 |
| » Defeated Twins (61-82), 4-0 | Cleveland Stadium (41-34) | 73-71 | Won 4 |
| » W: Tom Candiotti (14-11) L: Frank Viola (14-12) | Fourth | 13½ out |
| Tuesday, September 16 |
| » Lost to Twins (62-82), 7-3 | Cleveland Stadium (41-35) | |