| Sunday, January 12 |
| Former Cub Eddie Solomon dies in Macon, GA at the age of 35. |
| Monday, March 24 |
| Former Cub Hank Grampp dies in New York, NY at the age of 83. |
| Monday, April 7 |
| » Major-league debuts: John Kruk (Padres) |
| Tuesday, April 8 |
| » Lost to Cardinals (1-0), 2-1 | Busch Stadium II (0-1) | 0-1 | |
| » W: John Tudor (1-0) L: Rick Sutcliffe (0-1) | Second | 1 out |
| Thursday, April 10 |
| » Lost to Cardinals (2-0), 4-2 | Busch Stadium II (0-2) | 0-2 | Lost 2 |
| » W: Rick Ownbey (1-0) L: Dennis Eckersley (0-1) S: Todd Worrell (1) | Fifth | 2 out |
| Friday, April 11 |
| » Defeated Pirates (0-2), 5-4 | Three Rivers Stadium (1-0) | 1-2 | |
| » W: Steve Trout (1-0) L: Larry McWilliams (0-1) S: Lee Smith (1) | Third | 2 out |
| Saturday, April 12 |
| » Lost to Pirates (1-2), 3-1 | Three Rivers Stadium (1-1) | 1-3 | |
| » W: Rick Rhoden (1-0) L: Lee Smith (0-1) S: Cecilio Guante (1) | Fifth | 3 out |
| Sunday, April 13 |
| » Lost to Pirates (2-2), 8-0 | Three Rivers Stadium (1-2) | 1-4 | Lost 2 |
| » W: Rick Reuschel (1-1) L: Rick Sutcliffe (0-2) | Fifth | 3 out |
| Tuesday, April 15 |
| » Lost to Expos (3-3), 4-3 | Stade Olympique (0-1) | 1-5 | Lost 3 |
| » W: Jeff Reardon (1-0) L: Lee Smith (0-2) | Fifth | 4 out |
| Thursday, April 17 |
| » Defeated Expos (3-4), 7-6 | Stade Olympique (1-1) | 2-5 | |
| » W: Lee Smith (1-2) L: Jeff Reardon (1-1) | Sixth | 3½ out |
| Friday, April 18 |
| » Lost to Pirates (4-2), 4-0 | Wrigley Field (0-1) | 2-6 | |
| » W: Rick Rhoden (2-0) L: Rick Sutcliffe (0-3) | Sixth | 4½ out |
| Saturday, April 19 |
| » Lost to Pirates (5-2), 14-8 | Wrigley Field (0-2) | 2-7 | Lost 2 |
| » W: Rick Reuschel (2-1) L: Scott Sanderson (0-1) | Sixth | 5½ out |
| Tuesday, April 22 |
| » Defeated Cardinals (7-3), 3-2 | Wrigley Field (1-2) | 3-7 | |
| » W: Jay Baller (1-0) L: Pat Perry (1-1) | Fourth | 4 out |
| Wednesday, April 23 |
| » Defeated Cardinals (7-4), 6-0 | Wrigley Field (2-2) | 4-7 | Won 2 |
| » W: Scott Sanderson (1-1) L: Rick Ownbey (1-1) | Fifth | 3½ out |
| Thursday, April 24 |
| » Defeated Expos (5-8), 7-5 | Wrigley Field (3-2) | 5-7 | Won 3 |
| » W: Rick Sutcliffe (1-3) L: Bryn Smith (1-2) S: Jay Baller (1) | Fourth | 3½ out |
| Friday, April 25 |
| » Lost to Expos (6-8), 4-2 | Wrigley Field (3-3) | 5-8 | |
| » W: Jeff Reardon (2-1) L: Matt Keough (0-1) | Sixth | 4½ out |
| Saturday, April 26 |
| » Lost to Expos (7-8), 4-2 | Wrigley Field (3-4) | 5-9 | Lost 2 |
| » W: Tim Burke (1-0) L: George Frazier (0-1) S: Jeff Reardon (2) | Fifth | 5½ out |
| Sunday, April 27 |
| » Defeated Expos (7-9), 12-10 | Wrigley Field (4-4) | 6-9 | |
| » W: Ray Fontenot (1-0) L: Jeff Reardon (2-2) S: Jay Baller (2) | Fifth | 5½ out |
| Monday, April 28 |
| » Defeated Padres (10-9), 4-3 | San Diego/Jack Murphy Stadium (1-0) | 7-9 | Won 2 |
| » W: Matt Keough (1-1) L: Rich Gossage (2-1) S: Jay Baller (3) | Fourth | 5 out |
| Tuesday, April 29 |
| » Lost to Padres (11-9), 5-4 | San Diego/Jack Murphy Stadium (1-1) | 7-10 | |
| » W: Craig Lefferts (3-0) L: Ray Fontenot (1-1) | Fourth | 6 out |
| Wednesday, April 30 |
| » Lost to Dodgers (10-13), 4-0 | Dodger Stadium (0-1) | 7-11 | Lost 2 |
| » W: Bob Welch (3-1) L: Dennis Eckersley (0-2) | Fifth | 7 out |
| Thursday, May 1 |
| » Lost to Dodgers (11-13), 4-0 | Dodger Stadium (0-2) | 7-12 | Lost 3 |
| » W: Rick Honeycutt (1-2) L: Guy Hoffman (0-1) S: Tom Niedenfuer (3) | Sixth | 7 out |
| Friday, May 2 |
| » Defeated Giants (13-10), 6-5 | Candlestick Park (1-0) | 8-12 | |
| » W: Matt Keough (2-1) L: Mark Davis (1-2) S: Jay Baller (4) | Fourth | 7 out |
| Saturday, May 3 |
| » Defeated Giants (13-11), 6-5 | Candlestick Park (2-0) | 9-12 | Won 2 |
| » W: George Frazier (1-1) L: Greg Minton (1-2) S: Jay Baller (5) | Fourth | 7 out |
| Sunday, May 4 |
| » Lost to Giants (14-11), 2-1 | Candlestick Park (2-1) | 9-13 | |
| » W: Mike LaCoss (2-0) L: Rick Sutcliffe (1-4) | Sixth | 8½ out |
| » Lost to Giants (15-11), 2-1 | Candlestick Park (2-2) | 9-14 | Lost 2 |
| » W: Roger Mason (2-1) L: George Frazier (1-2) S: Jeff Robinson (2) | Sixth | 8½ out |
| Tuesday, May 6 |
| » Defeated Dodgers (13-15), 7-6 | Wrigley Field (5-4) | 10-14 | |
| » W: Lee Smith (2-2) L: Tom Niedenfuer (0-2) | Fourth | 8½ out |
| Wednesday, May 7 |
| » Lost to Dodgers (14-15), 8-4 | Wrigley Field (5-5) | 10-15 | |
| » W: Tom Niedenfuer (1-2) L: Jay Baller (1-1) | Fifth | 9½ out |
| Thursday, May 8 |
| » Defeated Dodgers (14-16), 6-5 | Wrigley Field (6-5) | 11-15 | |
| » W: Scott Sanderson (2-1) L: Jerry Reuss (2-1) S: Lee Smith (2) | Fifth | 9 out |
| Friday, May 9 |
| » Lost to Padres (15-14), 6-2 | Wrigley Field (6-6) | 11-16 | |
| » W: Andy Hawkins (2-2) L: Rick Sutcliffe (1-5) | Sixth | 10 out |
| Saturday, May 10 |
| » Defeated Padres (15-15), 6-5 | Wrigley Field (7-6) | 12-16 | |
| » W: Dennis Eckersley (1-2) L: LaMarr Hoyt (0-1) S: Lee Smith (3) | Fifth | 10 out |
| Sunday, May 11 |
| » Defeated Padres (15-16), 9-5 | Wrigley Field (8-6) | 13-16 | Won 2 |
| » W: Steve Trout (2-0) L: Mark Thurmond (2-2) S: Lee Smith (4) | Fifth | 9 out |
| Tuesday, May 13 |
| » Lost to Giants (19-14), 6-5 | Wrigley Field (8-7) | 13-17 | |
| » W: Greg Minton (2-2) L: Lee Smith (2-3) S: Bill Laskey (1) | Fifth | 9½ out |
| Wednesday, May 14 |
| » Lost to Giants (20-14), 11-3 | Wrigley Field (8-8) | 13-18 | Lost 2 |
| » W: Mike LaCoss (4-0) L: Rick Sutcliffe (1-6) | Sixth | 9½ out |
| Friday, May 16 |
| » Lost to Astros (20-13), 9-6 | Astrodome (0-1) | 13-19 | Lost 3 |
| » W: Julio Solano (3-0) L: Jay Baller (1-2) S: Dave Smith (10) | Sixth | 10 out |
| Saturday, May 17 |
| » Lost to Astros (21-13), 5-1 | Astrodome (0-2) | 13-20 | Lost 4 |
| » W: Mike Scott (4-2) L: Steve Trout (2-1) | Sixth | 10 out |
| Sunday, May 18 |
| » Defeated Astros (21-14), 5-2 | Astrodome (1-2) | 14-20 | |
| » W: Guy Hoffman (1-1) L: Bob Knepper (7-2) S: Lee Smith (5) | Fifth | 10 out |
| Tuesday, May 20 |
| » Lost to Braves (19-18), 8-3 | Atlanta-Fulton County Stadium (0-1) | 14-21 | |
| » W: David Palmer (3-2) L: Scott Sanderson (2-2) | Fifth | 11 out |
| Wednesday, May 21 |
| » Lost to Braves (20-18), 9-8 | Atlanta-Fulton County Stadium (0-2) | 14-22 | Lost 2 |
| » W: Jeff Dedmon (1-1) L: George Frazier (1-3) | Fifth | 12 out |
| Thursday, May 22 |
| » Lost to Braves (21-18), 2-0 | Atlanta-Fulton County Stadium (0-3) | 14-23 | Lost 3 |
| » W: Joe Johnson (6-3) L: Steve Trout (2-2) S: Paul Assenmacher (4) | Fifth | 12 out |
| Friday, May 23 |
| » Defeated Astros (22-17), 4-1 | Wrigley Field (9-8) | 15-23 | |
| » W: Rick Sutcliffe (2-6) L: Julio Solano (3-1) | Fifth | 11 out |
| Saturday, May 24 |
| » Defeated Astros (22-18), 4-3 | Wrigley Field (10-8) | 16-23 | Won 2 |
| » W: George Frazier (2-3) L: Dave Smith (0-2) S: Lee Smith (6) | Fifth | 11 out |
| Sunday, May 25 |
| » Lost to Astros (23-18), 3-1 | Wrigley Field (10-9) | 16-24 | |
| » W: Charlie Kerfeld (4-1) L: Lee Smith (2-4) S: Dave Smith (11) | Fifth | 12 out |
| Monday, May 26 |
| » Defeated Reds (16-24), 9-6 | Wrigley Field (11-9) | 17-24 | |
| » W: Dennis Eckersley (2-2) L: Scott Terry (0-1) S: Lee Smith (7) | Third | 11½ out |
| Tuesday, May 27 |
| » Lost to Reds (17-24), 5-4 | Wrigley Field (11-10) | 17-25 | |
| » W: Tom Browning (2-4) L: Steve Trout (2-3) S: Ron Robinson (3) | Third | 12½ out |
| Wednesday, May 28 |
| » Defeated Reds (17-25), 5-0 | Wrigley Field (12-10) | 18-25 | |
| » W: Rick Sutcliffe (3-6) L: Bill Gullickson (4-4) | Third | 12½ out |
| Former Cub Taylor Douthit dies in Fremont, CA at the age of 86. |
| Friday, May 30 |
| » Defeated Braves (24-22), 6-1 | Wrigley Field (13-10) | 19-25 | Won 2 |
| » W: Scott Sanderson (3-2) L: Rick Mahler (4-5) S: Ray Fontenot (1) | Fourth | 13 out |
| Saturday, May 31 |
| » Lost to Braves (25-22), 8-4 | Wrigley Field (13-11) | 19-26 | |
| » W: Jeff Dedmon (2-1) L: Dennis Eckersley (2-3) S: Gene Garber (3) | Fourth | 13 out |
| Sunday, June 1 |
| » Defeated Braves (25-23), 7-3 | Wrigley Field (14-11) | 20-26 | |
| » W: Guy Hoffman (2-1) L: Zane Smith (4-5) | Fourth | 12 out |
| Monday, June 2 |
| » Defeated Reds (18-28), 8-6 | Riverfront Stadium (1-0) | 21-26 | Won 2 |
| » W: Rick Sutcliffe (4-6) L: Bill Gullickson (4-5) S: Lee Smith (8) | Fourth | 12 out |
| Tuesday, June 3 |
| » Lost to Reds (19-28), 5-3 | Riverfront Stadium (1-1) | 21-27 | |
| » W: Ted Power (3-3) L: Jay Baller (1-3) S: John Franco (9) | Fourth | 12 out |
| Wednesday, June 4 |
| » Lost to Reds (20-28), 2-0 | Riverfront Stadium (1-2) | 21-28 | Lost 2 |
| » W: Tom Browning (3-5) L: Scott Sanderson (3-3) | Fifth | 13 out |
| Thursday, June 5 |
| » Lost to Cardinals (21-28), 4-3 | Busch Stadium II (0-3) | 21-29 | Lost 3 |
| » W: Bob Forsch (5-3) L: Matt Keough (2-2) S: Todd Worrell (9) | Sixth | 14 out |
| Friday, June 6 |
| » Defeated Cardinals (21-29), 9-3 | Busch Stadium II (1-3) | 22-29 | |
| » W: Jay Baller (2-3) L: Danny Cox (1-5) | Fourth | 13½ out |
| Saturday, June 7 |
| » Lost to Cardinals (22-29), 3-2 | Busch Stadium II (1-4) | 22-30 | |
| » W: John Tudor (6-3) L: Rick Sutcliffe (4-7) | Fifth | 14½ out |
| Sunday, June 8 |
| » Defeated Cardinals (22-30), 14-2 | Busch Stadium II (2-4) | 23-30 | |
| » W: Steve Trout (3-3) L: Greg Mathews (1-1) | Fourth | 14½ out |
| Monday, June 9 |
| » Lost to Pirates (22-30), 6-5 | Three Rivers Stadium (1-3) | 23-31 | |
| » W: Don Robinson (1-0) L: Jay Baller (2-4) | Fourth | 14½ out |
| Tuesday, June 10 |
| » Lost to Pirates (23-30), 6-4 | Three Rivers Stadium (1-4) | 23-32 | Lost 2 |
| » W: Bob Kipper (2-5) L: Dennis Eckersley (2-4) S: Cecilio Guante (2) | Fifth | 15½ out |
| Wednesday, June 11 |
| » Lost to Pirates (24-30), 5-3 | Three Rivers Stadium (1-5) | 23-33 | Lost 3 |
| » W: Rick Rhoden (6-3) L: Guy Hoffman (2-2) S: Don Robinson (1) | Fifth | 16½ out |
| Friday, June 13 |
| » Lost to Cardinals (23-33), 1-0 | Wrigley Field (14-12) | 23-34 | Lost 4 |
| » Manager: John Vukovich |
| » W: Greg Mathews (2-1) L: Rick Sutcliffe (4-8) S: Todd Worrell (10) | Fifth | 17 out |
| » Defeated Cardinals (23-34), 3-2 | Wrigley Field (15-12) | 24-34 | |
| » W: Lee Smith (3-4) L: Todd Worrell (3-5) | Fifth | 17 out |
| Saturday, June 14 |
| » Lost to Cardinals (24-34), 1-0 | Wrigley Field (15-13) | 24-35 | |
| » Manager: Gene Michael |
| » W: Ray Burris (3-2) L: Scott Sanderson (3-4) S: Todd Worrell (11) | Sixth | 18 out |
| Sunday, June 15 |
| » Defeated Cardinals (24-35), 4-3 | Wrigley Field (16-13) | 25-35 | |
| » W: Ray Fontenot (2-1) L: Todd Worrell (3-6) | Fourth | 18½ out |
| » Major-league debuts: Dave Martinez (Cubs) |
| Monday, June 16 |
| » Defeated Phillies (28-31), 7-5 | Wrigley Field (17-13) | 26-35 | Won 2 |
| » W: Jamie Moyer (1-0) L: Steve Carlton (4-8) S: Lee Smith (9) | Fourth | 18½ out |
| » Major-league debuts: Jamie Moyer (Cubs) |
| Tuesday, June 17 |
| » Lost to Phillies (29-31), 11-8 | Wrigley Field (17-14) | 26-36 | |
| » W: Kent Tekulve (1-1) L: Ray Fontenot (2-2) | Fourth | 18½ out |
| Wednesday, June 18 |
| » Defeated Phillies (29-32), 5-4 | Wrigley Field (18-14) | 27-36 | |
| » W: Lee Smith (4-4) L: Steve Bedrosian (2-3) | Fourth | 17½ out |
| Friday, June 20 |
| » Lost to Mets (45-18), 10-3 | Shea Stadium (0-1) | 27-37 | |
| » W: Sid Fernandez (8-2) L: Scott Sanderson (3-5) | Fourth | 18½ out |
| Saturday, June 21 |
| » Defeated Mets (45-19), 8-6 | Shea Stadium (1-1) | 28-37 | |
| » W: Ray Fontenot (3-2) L: Jesse Orosco (3-3) S: Lee Smith (10) | Fourth | 17½ out |
| Sunday, June 22 |
| » Lost to Mets (46-19), 4-2 | Shea Stadium (1-2) | 28-38 | |
| » W: Ron Darling (8-2) L: Rick Sutcliffe (4-9) | Fifth | 18½ out |
| Monday, June 23 |
| » Lost to Phillies (31-35), 19-1 | Veteran's Stadium (0-1) | 28-39 | Lost 2 |
| » W: Shane Rawley (10-4) L: Jamie Moyer (1-1) | Fifth | 18½ out |
| Tuesday, June 24 |
| » Lost to Phillies (32-35), 7-6 | Veteran's Stadium (0-2) | 28-40 | Lost 3 |
| » W: Steve Bedrosian (3-3) L: Lee Smith (4-5) | Fifth | 18½ out |
| Wednesday, June 25 |
| » Defeated Phillies (32-36), 10-7 | Veteran's Stadium (1-2) | 29-40 | |
| » W: Guy Hoffman (3-2) L: Charles Hudson (4-6) S: Lee Smith (11) | Fifth | 18½ out |
| Saturday, June 28 |
| » Lost to Mets (48-21), 5-2 | Wrigley Field (18-15) | 29-41 | |
| » W: Roger McDowell (7-0) L: Ray Fontenot (3-3) | Fifth | 19½ out |
| Sunday, June 29 |
| » Lost to Mets (49-21), 7-4 | Wrigley Field (18-16) | 29-42 | Lost 2 |
| » W: Dwight Gooden (9-3) L: Rick Sutcliffe (4-10) | Fifth | 20½ out |
| Monday, June 30 |
| » Lost to Expos (41-31), 4-3 | Wrigley Field (18-17) | 29-43 | Lost 3 |
| » W: Dan Schatzeder (3-1) L: Lee Smith (4-6) S: Bob McClure (4) | Fifth | 21½ out |
| Wednesday, July 2 |
| » Defeated Expos (41-32), 1-0 | Wrigley Field (19-17) | 30-43 | |
| » W: Dave Gumpert (1-0) L: Dan Schatzeder (3-2) S: Lee Smith (12) | Fifth | 21½ out |
| » Defeated Expos (41-33), 5-4 | Wrigley Field (20-17) | 31-43 | Won 2 |
| » W: Lee Smith (5-6) L: Bob McClure (2-2) | Fifth | 21½ out |
| Former Cub Peanuts Lowrey dies in Inglewood, CA at the age of 69. |
| Thursday, July 3 |
| » Lost to Padres (40-38), 4-1 | San Diego/Jack Murphy Stadium (1-2) | 31-44 | |
| » W: LaMarr Hoyt (3-4) L: Dennis Eckersley (2-5) | Fifth | 22½ out |
| Friday, July 4 |
| » Lost to Padres (41-38), 2-1 | San Diego/Jack Murphy Stadium (1-3) | 31-45 | Lost 2 |
| » W: Rich Gossage (4-3) L: Ray Fontenot (3-4) | Fifth | 23½ out |
| Saturday, July 5 |
| » Defeated Padres (41-39), 3-2 | San Diego/Jack Murphy Stadium (2-3) | 32-45 | |
| » W: Dave Gumpert (2-0) L: Craig Lefferts (5-3) S: Lee Smith (13) | Fifth | 22½ out |
| Sunday, July 6 |
| » Lost to Padres (42-39), 2-1 | San Diego/Jack Murphy Stadium (2-4) | 32-46 | |
| » W: Andy Hawkins (6-5) L: Scott Sanderson (3-6) S: Rich Gossage (15) | Fifth | 23½ out |
| Tuesday, July 8 |
| » Defeated Giants (45-38), 4-1 | Candlestick Park (3-2) | 33-46 | |
| » W: Dennis Eckersley (3-5) L: Mike Krukow (10-5) | Fifth | 22 out |
| Wednesday, July 9 |
| » Defeated Giants (45-39), 4-3 | Candlestick Park (4-2) | 34-46 | Won 2 |
| » W: Lee Smith (6-6) L: Juan Berenguer (1-2) S: Ray Fontenot (2) | Fourth | 21 out |
| Thursday, July 10 |
| » Lost to Dodgers (39-46), 11-4 | Dodger Stadium (0-3) | 34-47 | |
| » W: Orel Hershiser (8-6) L: Jamie Moyer (1-2) | Fourth | 22 out |
| Friday, July 11 |
| » Defeated Dodgers (39-47), 6-3 | Dodger Stadium (1-3) | 35-47 | |
| » W: Scott Sanderson (4-6) L: Rick Honeycutt (5-5) S: Lee Smith (14) | Fourth | 22 out |
| Saturday, July 12 |
| » Defeated Dodgers (39-48), 7-4 | Dodger Stadium (2-3) | 36-47 | Won 2 |
| » W: Ed Lynch (1-0) L: Tom Niedenfuer (5-4) | Fourth | 22 out |
| Sunday, July 13 |
| » Lost to Dodgers (40-48), 4-3 | Dodger Stadium (2-4) | 36-48 | |
| » W: Ken Howell (3-6) L: Lee Smith (6-7) | Fourth | 23 out |
| Thursday, July 17 |
| » Lost to Giants (49-40), 6-4 | Wrigley Field (20-18) | 36-49 | Lost 2 |
| » W: Vida Blue (7-4) L: Ed Lynch (1-1) | Fifth | 24 out |
| Friday, July 18 |
| » Defeated Giants (49-41), 2-1 | Wrigley Field (21-18) | 37-49 | |
| » W: Scott Sanderson (5-6) L: Mike LaCoss (9-4) S: Lee Smith (15) | Fourth | 23 out |
| Saturday, July 19 |
| » Defeated Giants (49-42), 11-6 | Wrigley Field (22-18) | 38-49 | Won 2 |
| » W: Guy Hoffman (4-2) L: Mike Krukow (11-6) S: Dave Gumpert (2) | Fourth | 22 out |
| Sunday, July 20 |
| » Lost to Giants (50-42), 5-4 | Wrigley Field (22-19) | 38-50 | |
| » W: Scott Garrelts (8-7) L: Dennis Eckersley (3-6) | Fourth | 22 out |
| Monday, July 21 |
| » Defeated Padres (46-47), 6-1 | Wrigley Field (23-19) | 39-50 | |
| » W: Jamie Moyer (2-2) L: LaMarr Hoyt (5-5) | Fourth | 22 out |
| Tuesday, July 22 |
| » Defeated Padres (46-48), 6-4 | Wrigley Field (24-19) | 40-50 | Won 2 |
| » W: Ed Lynch (2-1) L: Lance McCullers (5-4) S: Lee Smith (16) | Fourth | 22 out |
| Wednesday, July 23 |
| » Lost to Padres (47-48), 7-5 | Wrigley Field (24-20) | 40-51 | |
| » W: Craig Lefferts (7-4) L: Ray Fontenot (3-5) S: Rich Gossage (16) | Fifth | 23 out |
| Friday, July 25 |
| » Defeated Dodgers (45-51), 8-3 | Wrigley Field (25-20) | 41-51 | |
| » W: Steve Trout (4-3) L: Bob Welch (4-9) S: Lee Smith (17) | Fifth | 22½ out |
| Saturday, July 26 |
| » Defeated Dodgers (45-52), 9-4 | Wrigley Field (26-20) | 42-51 | Won 2 |
| » W: Dennis Eckersley (4-6) L: Rick Honeycutt (6-6) | Fifth | 21 out |
| Sunday, July 27 |
| » Lost to Dodgers (46-52), 13-11 | Wrigley Field (26-21) | 42-52 | |
| » W: Ken Howell (4-6) L: Frank DiPino (1-4) | Fifth | 22 out |
| Monday, July 28 |
| » Lost to Mets (65-30), 9-2 | Shea Stadium (1-3) | 42-53 | Lost 2 |
| » W: Bob Ojeda (12-2) L: Scott Sanderson (5-7) S: Roger McDowell (10) | Fifth | 23 out |
| Tuesday, July 29 |
| » Lost to Mets (66-30), 3-0 | Shea Stadium (1-4) | 42-54 | Lost 3 |
| » W: Ron Darling (11-3) L: Steve Trout (4-4) | Fifth | 23 out |
| » Defeated Mets (66-31), 2-1 | Shea Stadium (2-4) | 43-54 | |
| » W: Jamie Moyer (3-2) L: Doug Sisk (2-2) S: Lee Smith (18) | Fifth | 23 out |
| Wednesday, July 30 |
| » Defeated Mets (66-32), 4-3 | Shea Stadium (3-4) | 44-54 | Won 2 |
| » W: Dennis Eckersley (5-6) L: Sid Fernandez (12-4) S: Lee Smith (19) | Fifth | 22 out |
| Friday, August 1 |
| » Lost to Phillies (50-50), 4-3 | Veteran's Stadium (1-3) | 44-55 | |
| » W: Kent Tekulve (4-1) L: Frank DiPino (1-5) | Fifth | 23 out |
| Saturday, August 2 |
| » Lost to Phillies (51-50), 12-2 | Veteran's Stadium (1-4) | 44-56 | Lost 2 |
| » W: Kevin Gross (7-8) L: Scott Sanderson (5-8) | Fifth | 24 out |
| Sunday, August 3 |
| » Lost to Phillies (52-50), 6-2 | Veteran's Stadium (1-5) | 44-57 | Lost 3 |
| » W: Steve Bedrosian (8-3) L: Frank DiPino (1-6) | Fifth | 25 out |
| Monday, August 4 |
| » Defeated Mets (69-33), 4-2 | Wrigley Field (27-21) | 45-57 | |
| » W: Dennis Eckersley (6-6) L: Ron Darling (11-4) S: Lee Smith (20) | Fifth | 24 out |
| Tuesday, August 5 |
| » Defeated Mets (69-34), 8-5 | Wrigley Field (28-21) | 46-57 | Won 2 |
| » W: Lee Smith (7-7) L: Roger McDowell (9-6) | Fifth | 23 out |
| Wednesday, August 6 |
| » Lost to Mets (70-34), 7-6 | Wrigley Field (28-22) | 46-58 | |
| » W: Roger McDowell (10-6) L: George Frazier (2-4) | Fifth | 24 out |
| Thursday, August 7 |
| » Lost to Mets (71-34), 12-3 | Wrigley Field (28-23) | 46-59 | Lost 2 |
| » W: Rick Aguilera (6-3) L: Scott Sanderson (5-9) | Fifth | 26 out |
| » Lost to Mets (72-34), 7-6 | Wrigley Field (28-24) | 46-60 | Lost 3 |
| » W: Rick Anderson (1-0) L: Steve Trout (4-5) S: Jesse Orosco (15) | Fifth | 26 out |
| Friday, August 8 |
| » Defeated Phillies (52-55), 2-1 | Wrigley Field (29-24) | 47-60 | |
| » W: Steve Trout (5-5) L: Bruce Ruffin (3-3) S: Lee Smith (21) | Fourth | 25 out |
| Saturday, August 9 |
| » Lost to Phillies (53-55), 4-2 | Wrigley Field (29-25) | 47-61 | |
| » W: Charles Hudson (7-10) L: Dennis Eckersley (6-7) S: Steve Bedrosian (14) | Fifth | 26 out |
| Sunday, August 10 |
| » Defeated Phillies (53-56), 4-0 | Wrigley Field (30-25) | 48-61 | |
| » W: Ed Lynch (3-1) L: Mike Maddux (0-5) | Fourth | 26 out |
| Monday, August 11 |
| » Lost to Pirates (44-64), 10-7 | Wrigley Field (30-26) | 48-62 | |
| » W: Rick Rhoden (12-7) L: Jamie Moyer (3-3) S: Don Robinson (7) | Fifth | 27½ out |
| » Lost to Pirates (45-64), 10-8 | Wrigley Field (30-27) | 48-63 | Lost 2 |
| » W: Barry Jones (1-1) L: Frank DiPino (1-7) | Fifth | 27½ out |
| Tuesday, August 12 |
| » Defeated Pirates (45-65), 3-1 | Wrigley Field (31-27) | 49-63 | |
| » W: Scott Sanderson (6-9) L: Larry McWilliams (2-8) S: Lee Smith (22) | Fourth | 26½ out |
| Wednesday, August 13 |
| » Defeated Pirates (45-66), 9-8 | Wrigley Field (32-27) | 50-63 | Won 2 |
| » W: Frank DiPino (2-7) L: Don Robinson (2-2) S: Lee Smith (23) | Fourth | 25½ out |
| Thursday, August 14 |
| » Lost to Expos (57-54), 5-4 | Stade Olympique (1-2) | 50-64 | |
| » W: Andy McGaffigan (7-4) L: Ron Davis (2-7) | Fifth | 26 out |
| Friday, August 15 |
| » Lost to Expos (58-54), 5-2 | Stade Olympique (1-3) | 50-65 | Lost 2 |
| » W: Dennis Martinez (2-4) L: Steve Trout (5-6) S: Andy McGaffigan (1) | Fourth | 26½ out |
| » Lost to Expos (59-54), 5-1 | Stade Olympique (1-4) | 50-66 | Lost 3 |
| » W: Tim Burke (8-4) L: Ed Lynch (3-2) S: Bob McClure (6) | Fourth | 26½ out |
| Saturday, August 16 |
| » Defeated Expos (59-55), 5-0 | Stade Olympique (2-4) | 51-66 | |
| » W: Jamie Moyer (4-3) L: Floyd Youmans (11-9) | Fifth | 25½ out |
| Sunday, August 17 |
| » Defeated Expos (59-56), 2-1 | Stade Olympique (3-4) | 52-66 | Won 2 |
| » W: Lee Smith (8-7) L: Jeff Reardon (6-8) | Fourth | 25 out |
| Tuesday, August 19 |
| » Lost to Braves (56-62), 7-2 | Wrigley Field (32-28) | 52-67 | |
| » W: Doyle Alexander (8-8) L: Rick Sutcliffe (4-11) | Fifth | 26½ out |
| Wednesday, August 20 |
| » Lost to Braves (57-62), 8-3 | Wrigley Field (32-29) | 52-68 | Lost 2 |
| » W: David Palmer (9-8) L: Dennis Eckersley (6-8) | Fifth | 27½ out |
| Thursday, August 21 |
| » Lost to Braves (58-62), 5-2 | Wrigley Field (32-30) | 52-69 | Lost 3 |
| » W: Jim Acker (5-6) L: Ed Lynch (3-3) S: Gene Garber (19) | Fifth | 28 out |
| Friday, August 22 |
| » Defeated Reds (60-62), 3-2 | Wrigley Field (33-30) | 53-69 | |
| » W: Jamie Moyer (5-3) L: Ted Power (4-6) S: Lee Smith (24) | Fifth | 28 out |
| Saturday, August 23 |
| » Lost to Reds (61-62), 7-3 | Wrigley Field (33-31) | 53-70 | |
| » W: Tom Browning (11-10) L: Scott Sanderson (6-10) | Fifth | 29 out |
| Sunday, August 24 |
| » Lost to Reds (62-62), 7-1 | Wrigley Field (33-32) | 53-71 | Lost 2 |
| » W: Bill Gullickson (11-8) L: Ron Davis (2-8) | Fifth | 29 out |
| Monday, August 25 |
| » Lost to Astros (71-54), 3-2 | Astrodome (1-3) | 53-72 | Lost 3 |
| » W: Charlie Kerfeld (8-2) L: Lee Smith (8-8) S: Dave Smith (26) | Fifth | 30 out |
| Tuesday, August 26 |
| » Defeated Astros (71-55), 5-3 | Astrodome (2-3) | 54-72 | |
| » W: Ed Lynch (4-3) L: Danny Darwin (6-9) S: Lee Smith (25) | Fifth | 30 out |
| Wednesday, August 27 |
| » Lost to Astros (72-55), 7-1 | Astrodome (2-4) | 54-73 | |
| » W: Nolan Ryan (9-8) L: Jamie Moyer (5-4) S: Charlie Kerfeld (6) | Fifth | 31 out |
| Friday, August 29 |
| » Defeated Braves (59-68), 7-3 | Atlanta-Fulton County Stadium (1-3) | 55-73 | |
| » W: Scott Sanderson (7-10) L: Zane Smith (7-13) | Fifth | 31 out |
| Saturday, August 30 |
| » Lost to Braves (60-68), 4-3 | Atlanta-Fulton County Stadium (1-4) | 55-74 | |
| » W: Doyle Alexander (9-9) L: Rick Sutcliffe (4-12) S: Gene Garber (21) | Fifth | 32 out |
| Sunday, August 31 |
| » Lost to Braves (61-68), 4-3 | Atlanta-Fulton County Stadium (1-5) | 55-75 | Lost 2 |
| » W: Jeff Dedmon (5-6) L: Lee Smith (8-9) | Fifth | 32 out |
| Monday, September 1 |
| » Lost to Astros (74-57), 6-4 | Wrigley Field (33-33) | 55-76 | Lost 3 |
| » W: Danny Darwin (7-9) L: Ed Lynch (4-4) S: Dave Smith (28) | Fifth | 33 out |
| Wednesday, September 3 |
| » Lost to Astros (75-57), 8-7 | Wrigley Field (33-34) | 55-77 | Lost 4 |
| » W: Danny Darwin (8-9) L: Greg Maddux (0-1) | Fifth | 34 out |
| » Lost to Astros (76-57), 8-2 | Wrigley Field (33-35) | 55-78 | Lost 5 |
| » W: Mike Scott (15-9) L: Scott Sanderson (7-11) | Fifth | 34 out |
| » Major-league debuts: Greg Maddux (Cubs) |
| Friday, September 5 |
| » Lost to Reds (69-65), 11-2 | Riverfront Stadium (1-3) | 55-79 | Lost 6 |
| » W: Tom Browning (12-11) L: Rick Sutcliffe (4-13) | Fifth | 34½ out |
| Saturday, September 6 |
| » Lost to Reds (70-65), 5-1 | Riverfront Stadium (1-4) | 55-80 | Lost 7 |
| » W: Ted Power (6-6) L: Dennis Eckersley (6-9) | Fifth | 35½ out |
| Sunday, September 7 |
| » Defeated Reds (70-66), 11-3 | Riverfront Stadium (2-4) | 56-80 | |
| » W: Greg Maddux (1-1) L: Bill Gullickson (13-9) | Fifth | 36 out |
| Monday, September 8 |
| » Defeated Phillies (71-66), 7-4 | Wrigley Field (34-35) | 57-80 | Won 2 |
| » W: Ed Lynch (5-4) L: Mike Maddux (2-6) S: Lee Smith (26) | Fifth | 35 out |
| » Major-league debuts: Rafael Palmeiro (Cubs) |
| Tuesday, September 9 |
| » Defeated Phillies (71-67), 8-6 | Wrigley Field (35-35) | 58-80 | Won 3 |
| » W: Lee Smith (9-9) L: Steve Bedrosian (8-5) | Fifth | 34 out |
| Wednesday, September 10 |
| » Defeated Phillies (71-68), 8-7 | Wrigley Field (36-35) | 59-80 | Won 4 |
| » W: Guy Hoffman (5-2) L: Kent Tekulve (10-4) S: Lee Smith (27) | Fifth | 34 out |
| Friday, September 12 |
| » Defeated Pirates (56-83), 9-8 | Three Rivers Stadium (2-5) | 60-80 | Won 5 |
| » W: Frank DiPino (3-7) L: Don Robinson (2-4) S: Dave Gumpert (3) | Fifth | 33 out |
| Saturday, September 13 |
| » Lost to Pirates (57-83), 5-2 | Three Rivers Stadium (2-6) | 60-81 | |
| » W: Bob Patterson (2-2) L: Greg Maddux (1-2) S: Don Robinson (11) | Fifth | 33 out |
| Sunday, September 14 |
| » Lost to Pirates (58-83), 9-2 | Three Rivers Stadium (2-7) | 60-82 | Lost 2 |
| » W: Rick Reuschel (9-16) L: Drew Hall (0-1) | Fifth | 33 out |
| » Major-league debuts: Drew Hall (Cubs) |
| Monday, September 15 |
| » Defeated Expos (70-71), 7-3 | Stade Olympique (4-4) | 61-82 | |
| » W: Jamie Moyer (6-4) L: Sergio Valdez (0-2) S: Scott Sanderson (1) | Fifth | 32 out |
| Tuesday, September 16 |
| » Lost to Expos (71-71), 4-1 | Stade Olympique (4-5) | 61-83 | |
| » W: Jay Tibbs (7-8) L: Rick Sutcliffe (4-14) | Fifth | 33 out |
| Wednesday, September 17 |
| » Lost to Mets (95-50), 4-2 | Shea Stadium (3-5) | 61-84 | Lost 2 |
| » W: Dwight Gooden (15-6) L: Dennis Eckersley (6-10) | Fifth | 34 out |
| Thursday, September 18 |
| » Lost to Mets (96-50), 5-0 | Shea Stadium (3-6) | 61-85 | Lost 3 |
| » W: Rick Anderson (2-1) L: Greg Maddux (1-3) | Fifth | 35 out |
| Friday, September 19 |
| » Defeated Pirates (60-87), 8-2 | Wrigley Field (37-35) | 62-85 | |
| » W: Scott Sanderson (8-11) L: Hipolito Pena (0-1) | Fifth | 34 out |
| Saturday, September 20 |
| » Defeated Pirates (60-88), 1-0 | Wrigley Field (38-35) | 63-85 | Won 2 |
| » W: Jamie Moyer (7-4) L: Rick Rhoden (15-10) S: Lee Smith (28) | Fifth | 34 out |
| Sunday, September 21 |
| » Defeated Pirates (60-89), 3-2 | Wrigley Field (39-35) | 64-85 | Won 3 |
| » W: Scott Sanderson (9-11) L: Hipolito Pena (0-2) S: Lee Smith (29) | Fifth | 33 out |
| Monday, September 22 |
| » Lost to Expos (74-75), 5-2 | Wrigley Field (39-36) | 64-86 | |
| » W: Floyd Youmans (13-10) L: Dennis Eckersley (6-11) S: Jeff Reardon (35) | Fifth | 34 out |
| Tuesday, September 23 |
| » Lost to Expos (75-75), 10-5 | Wrigley Field (39-37) | 64-87 | Lost 2 |
| » W: Randy St. Claire (2-0) L: Greg Maddux (1-4) S: Andy McGaffigan (2) | Fifth | 35 out |
| Wednesday, September 24 |
| » Defeated Mets (99-53), 8-2 | Wrigley Field (40-37) | 65-87 | |
| » W: Drew Hall (1-1) L: Rick Aguilera (8-7) | Fifth | 34 out |
| Thursday, September 25 |
| » Lost to Mets (100-53), 6-5 | Wrigley Field (40-38) | 65-88 | |
| » W: Roger McDowell (14-9) L: Ed Lynch (5-5) S: Jesse Orosco (20) | Fifth | 35 out |
| Friday, September 26 |
| » Defeated Cardinals (77-77), 4-1 | Busch Stadium II (3-4) | 66-88 | |
| » W: Rick Sutcliffe (5-14) L: Tim Conroy (5-10) S: Lee Smith (30) | Fifth | 35 out |
| Saturday, September 27 |
| » Defeated Cardinals (77-78), 5-3 | Busch Stadium II (4-4) | 67-88 | Won 2 |
| » W: Ed Lynch (6-5) L: Ray Soff (4-1) | Fifth | 35 out |
| Sunday, September 28 |
| » Lost to Cardinals (78-78), 4-1 | Busch Stadium II (4-5) | 67-89 | |
| » W: Greg Mathews (11-8) L: Steve Trout (5-7) S: Todd Worrell (36) | Fifth | 36 out |
| Monday, September 29 |
| » Defeated Phillies (83-74), 8-3 | Veteran's Stadium (2-5) | 68-89 | |
| » W: Greg Maddux (2-4) L: Mike Maddux (3-7) | Fifth | 35½ out |
| Tuesday, September 30 |
| » Lost to Phillies (84-74), 9-2 | Veteran's Stadium (2-6) | 68-90 | |
| » W: Bruce Ruffin (9-4) L: Drew Hall (1-2) | Fifth | 35½ out |
| Saturday, October 4 |
| » Defeated Cardinals (79-81), 8-7 | Wrigley Field (41-38) | 69-90 | |
| » W: Ed Lynch (7-5) L: Bob Forsch (14-10) S: Lee Smith (31) | Fifth | 37 out |
| Sunday, October 5 |
| » Defeated Cardinals (79-82), 8-1 | Wrigley Field (42-38) | 70-90 | Won 2 |
| » W: Guy Hoffman (6-2) L: Danny Cox (12-13) S: Drew Hall (1) | Fifth | 37 out |
| Sunday, October 26 |
| Former Cub Ed Holley dies in Paducah, KY at the age of 88. |
Game information provided by Retrosheet (www.retrosheet.org) |