| Monday, April 7 |
| » Defeated White Sox (0-1), 5-3 | Comiskey Park I (1-0) | 1-0 | |
| » W: Teddy Higuera (1-0) L: Tom Seaver (0-1) S: Mark Clear (1) | First | -- |
| Wednesday, April 9 |
| » Defeated White Sox (0-2), 4-3 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » W: Tim Leary (1-0) L: Richard Dotson (0-1) S: Ray Searage (1) | First | -- |
| » Major-league debuts: Bobby Bonilla (White Sox) |
| Thursday, April 10 |
| » Defeated White Sox (0-3), 8-5 | Comiskey Park I (3-0) | 3-0 | Won 3 |
| » W: Danny Darwin (1-0) L: Bob James (0-1) | First | -- |
| » Major-league debuts: Juan Nieves (Brewers) |
| Friday, April 11 |
| » Lost to Yankees (3-1), 3-2 | Yankee Stadium (0-1) | 3-1 | |
| » W: Bob Tewksbury (1-0) L: Bill Wegman (0-1) S: Rod Scurry (1) | First | -- |
| » Major-league debuts: Bob Tewksbury (Yankees) Dan Plesac (Brewers) |
| Saturday, April 12 |
| » Lost to Yankees (4-1), 7-3 | Yankee Stadium (0-2) | 3-2 | Lost 2 |
| » W: Dennis Rasmussen (1-0) L: Teddy Higuera (1-1) S: Dave Righetti (2) | Second | 1 out |
| » Major-league debuts: Juan Castillo (Brewers) |
| Sunday, April 13 |
| » Lost to Yankees (5-1), 3-2 | Yankee Stadium (0-3) | 3-3 | Lost 3 |
| » W: Ron Guidry (2-0) L: Jaime Cocanower (0-1) S: Dave Righetti (3) | Second | 2 out |
| Monday, April 14 |
| » Lost to Rangers (4-3), 10-1 | County Stadium (0-1) | 3-4 | Lost 4 |
| » W: Ed Correa (1-1) L: Tim Leary (1-1) | Fourth | 2½ out |
| Thursday, April 17 |
| » Lost to Rangers (5-3), 7-5 | County Stadium (0-2) | 3-5 | Lost 5 |
| » W: Greg Harris (2-1) L: Ray Searage (0-1) | Fifth | 3 out |
| Friday, April 18 |
| » Defeated Yankees (6-3), 6-5 | County Stadium (1-2) | 4-5 | |
| » W: Dan Plesac (1-0) L: Brian Fisher (0-1) | Fourth | 2 out |
| Saturday, April 19 |
| » Defeated Yankees (6-4), 4-3 | County Stadium (2-2) | 5-5 | Won 2 |
| » W: Bob McClure (1-0) L: Rod Scurry (0-1) | Third | 1 out |
| Sunday, April 20 |
| » Lost to Yankees (7-4), 5-4 | County Stadium (2-3) | 5-6 | |
| » W: Dave Righetti (2-0) L: Mark Clear (0-1) | Fifth | 2 out |
| Tuesday, April 22 |
| » Lost to White Sox (3-10), 5-4 | County Stadium (2-4) | 5-7 | Lost 2 |
| » W: Joel Davis (1-0) L: Danny Darwin (1-1) S: Bob James (1) | Sixth | 3½ out |
| Wednesday, April 23 |
| » Lost to White Sox (4-10), 2-1 | County Stadium (2-5) | 5-8 | Lost 3 |
| » W: Tom Seaver (2-2) L: Dan Plesac (1-1) S: Bob James (2) | Sixth | 4½ out |
| Friday, April 25 |
| » Defeated Rangers (8-7), 11-1 | Arlington Stadium (1-0) | 6-8 | |
| » W: Teddy Higuera (2-1) L: Jose Guzman (1-3) | Sixth | 5 out |
| Saturday, April 26 |
| » Defeated Rangers (8-8), 10-2 | Arlington Stadium (2-0) | 7-8 | Won 2 |
| » W: Tim Leary (2-1) L: Ed Correa (1-2) | Fourth | 4 out |
| Sunday, April 27 |
| » Lost to Rangers (9-8), 6-2 | Arlington Stadium (2-1) | 7-9 | |
| » W: Bobby Witt (2-0) L: Juan Nieves (0-1) | Fifth | 4 out |
| Tuesday, April 29 |
| » Defeated Athletics (11-9), 5-4 | County Stadium (3-5) | 8-9 | |
| » W: Bob McClure (2-0) L: Jay Howell (0-2) | Fourth | 4 out |
| Wednesday, April 30 |
| » Defeated Athletics (11-10), 5-1 | County Stadium (4-5) | 9-9 | Won 2 |
| » W: Teddy Higuera (3-1) L: Jose Rijo (1-2) | Fourth | 4 out |
| Thursday, May 1 |
| » Lost to Athletics (12-10), 7-2 | County Stadium (4-6) | 9-10 | |
| » W: Moose Haas (5-0) L: Tim Leary (2-2) | Sixth | 4 out |
| Friday, May 2 |
| » Defeated Angels (14-9), 5-4 | County Stadium (5-6) | 10-10 | |
| » W: Juan Nieves (1-1) L: Don Sutton (0-3) S: Dan Plesac (1) | Fourth | 3 out |
| Saturday, May 3 |
| » Defeated Angels (14-10), 4-3 | County Stadium (6-6) | 11-10 | Won 2 |
| » W: Mark Clear (1-1) L: Donnie Moore (1-2) | Fourth | 3 out |
| Sunday, May 4 |
| » Defeated Angels (14-11), 5-3 | County Stadium (7-6) | 12-10 | Won 3 |
| » W: Teddy Higuera (4-1) L: Kirk McCaskill (2-2) S: Mark Clear (2) | Fourth | 2 out |
| Monday, May 5 |
| » Defeated Mariners (9-17), 3-1 | County Stadium (8-6) | 13-10 | Won 4 |
| » W: Tim Leary (3-2) L: Mark Langston (1-3) S: Dan Plesac (2) | Fourth | 2 out |
| Tuesday, May 6 |
| » Defeated Mariners (9-18), 10-0 | County Stadium (9-6) | 14-10 | Won 5 |
| » W: Juan Nieves (2-1) L: Bill Swift (0-2) | Fourth | 2 out |
| Wednesday, May 7 |
| » Lost to Athletics (15-13), 7-6 | Oakland-Alameda County Stadium (0-1) | 14-11 | |
| » W: Joaquin Andujar (4-1) L: Bill Wegman (0-2) S: Steve Ontiveros (2) | Fourth | 3 out |
| Thursday, May 8 |
| » Lost to Athletics (16-13), 2-1 | Oakland-Alameda County Stadium (0-2) | 14-12 | Lost 2 |
| » W: Chris Codiroli (3-3) L: Teddy Higuera (4-2) S: Steve Ontiveros (3) | Fourth | 3½ out |
| Friday, May 9 |
| » Defeated Angels (16-14), 16-5 | Anaheim Stadium (1-0) | 15-12 | |
| » W: Danny Darwin (2-1) L: Kirk McCaskill (2-3) | Fourth | 3 out |
| Saturday, May 10 |
| » Defeated Angels (16-15), 4-2 | Anaheim Stadium (2-0) | 16-12 | Won 2 |
| » W: Juan Nieves (3-1) L: Mike Witt (2-3) S: Dan Plesac (3) | Fourth | 3 out |
| Sunday, May 11 |
| » Lost to Angels (17-15), 5-1 | Anaheim Stadium (2-1) | 16-13 | |
| » W: Jim Slaton (4-1) L: Bill Wegman (0-3) S: Doug Corbett (3) | Fourth | 3½ out |
| Monday, May 12 |
| » Lost to Mariners (12-21), 6-0 | Kingdome (0-1) | 16-14 | Lost 2 |
| » W: Matt Young (3-2) L: Teddy Higuera (4-3) | Third | 3½ out |
| » Major-league debuts: Dale Sveum (Brewers) |
| Tuesday, May 13 |
| » Lost to Mariners (13-21), 8-5 | Kingdome (0-2) | 16-15 | Lost 3 |
| » W: Mike Morgan (3-3) L: Tim Leary (3-3) S: Pete Ladd (2) | Fifth | 4½ out |
| Wednesday, May 14 |
| » Defeated Mariners (13-22), 9-6 | Kingdome (1-2) | 17-15 | |
| » W: Dan Plesac (2-1) L: Mike Moore (2-4) | Fourth | 3½ out |
| Friday, May 16 |
| » Defeated Twins (13-22), 7-6 | County Stadium (10-6) | 18-15 | Won 2 |
| » W: Mark Clear (2-1) L: Ron Davis (1-3) | Third | 2½ out |
| Saturday, May 17 |
| » Defeated Twins (13-23), 4-1 | County Stadium (11-6) | 19-15 | Won 3 |
| » W: Teddy Higuera (5-3) L: Mark Portugal (0-4) | Third | 2½ out |
| Sunday, May 18 |
| » Lost to Twins (14-23), 5-3 | County Stadium (11-7) | 19-16 | |
| » W: Bert Blyleven (4-3) L: Tim Leary (3-4) | Fourth | 3½ out |
| Tuesday, May 20 |
| » Defeated Indians (19-18), 12-9 | County Stadium (12-7) | 20-16 | |
| » W: Dan Plesac (3-1) L: Jamie Easterly (0-1) | Third | 4 out |
| Wednesday, May 21 |
| » Lost to Indians (20-18), 4-2 | County Stadium (12-8) | 20-17 | |
| » W: Tom Candiotti (3-4) L: Bill Wegman (0-4) | Fourth | 5 out |
| Thursday, May 22 |
| » Lost to Indians (21-18), 5-4 | County Stadium (12-9) | 20-18 | Lost 2 |
| » W: Neal Heaton (2-3) L: Teddy Higuera (5-4) S: Scott Bailes (4) | Fifth | 5½ out |
| Friday, May 23 |
| » Lost to Twins (15-26), 8-7 | Hubert H. Humphrey Metrodome (0-1) | 20-19 | Lost 3 |
| » W: Frank Pastore (1-0) L: Dan Plesac (3-2) | Fifth | 6½ out |
| Saturday, May 24 |
| » Defeated Twins (15-27), 6-3 | Hubert H. Humphrey Metrodome (1-1) | 21-19 | |
| » W: Juan Nieves (4-1) L: Frank Viola (4-5) | Fifth | 5½ out |
| Sunday, May 25 |
| » Lost to Twins (16-27), 4-3 | Hubert H. Humphrey Metrodome (1-2) | 21-20 | |
| » W: Mike Smithson (5-3) L: Bill Wegman (0-5) | Fifth | 6½ out |
| Monday, May 26 |
| » Defeated Royals (20-23), 4-0 | Royals Stadium (1-0) | 22-20 | |
| » W: Danny Darwin (3-1) L: Charlie Leibrandt (4-3) | Fourth | 6½ out |
| Tuesday, May 27 |
| » Defeated Royals (20-24), 9-1 | Royals Stadium (2-0) | 23-20 | Won 2 |
| » W: Teddy Higuera (6-4) L: Danny Jackson (2-1) | Fourth | 6½ out |
| Wednesday, May 28 |
| » Lost to Royals (21-24), 4-3 | Royals Stadium (2-1) | 23-21 | |
| » W: Steve Farr (3-1) L: Mark Clear (2-2) | Fifth | 7½ out |
| Friday, May 30 |
| » Defeated Indians (22-24), 11-7 | Cleveland Stadium (1-0) | 24-21 | |
| » W: Juan Nieves (5-1) L: Phil Niekro (3-4) S: Mark Clear (3) | Fourth | 6½ out |
| Saturday, May 31 |
| » Lost to Indians (23-24), 3-2 | Cleveland Stadium (1-1) | 24-22 | |
| » W: Scott Bailes (5-4) L: Dan Plesac (3-3) | Fourth | 7½ out |
| Sunday, June 1 |
| » Lost to Indians (24-24), 9-7 | Cleveland Stadium (1-2) | 24-23 | Lost 2 |
| » W: Scott Bailes (6-4) L: Bob McClure (2-1) S: Ernie Camacho (7) | Fourth | 8½ out |
| Monday, June 2 |
| » Defeated Royals (24-25), 7-2 | County Stadium (13-9) | 25-23 | |
| » W: Teddy Higuera (7-4) L: Danny Jackson (2-2) | Fourth | 8½ out |
| Tuesday, June 3 |
| » Lost to Royals (25-25), 4-1 | County Stadium (13-10) | 25-24 | |
| » W: Bret Saberhagen (3-5) L: Tim Leary (3-5) | Fourth | 9½ out |
| Wednesday, June 4 |
| » Lost to Royals (26-25), 8-6 | County Stadium (13-11) | 25-25 | Lost 2 |
| » W: Dennis Leonard (6-4) L: Juan Nieves (5-2) S: Dan Quisenberry (4) | Fourth | 10½ out |
| Thursday, June 5 |
| » Defeated Red Sox (36-16), 7-5 | County Stadium (14-11) | 26-25 | |
| » W: Bill Wegman (1-5) L: Jeff Sellers (0-1) S: Mark Clear (4) | Fourth | 9½ out |
| Friday, June 6 |
| » Lost to Red Sox (37-16), 3-0 | County Stadium (14-12) | 26-26 | |
| » W: Roger Clemens (10-0) L: Danny Darwin (3-2) | Fourth | 10½ out |
| Saturday, June 7 |
| » Defeated Red Sox (37-17), 3-0 | County Stadium (15-12) | 27-26 | |
| » W: Teddy Higuera (8-4) L: Oil Can Boyd (7-4) | Fourth | 9½ out |
| Sunday, June 8 |
| » Defeated Red Sox (37-18), 7-3 | County Stadium (16-12) | 28-26 | Won 2 |
| » W: Tim Leary (4-5) L: Mike Brown (4-2) S: Dan Plesac (4) | Fourth | 8½ out |
| Monday, June 9 |
| » Defeated Orioles (33-21), 3-2 | County Stadium (17-12) | 29-26 | Won 3 |
| » W: Dan Plesac (4-3) L: Storm Davis (5-5) | Fourth | 7½ out |
| Tuesday, June 10 |
| » Defeated Orioles (33-22), 6-3 | County Stadium (18-12) | 30-26 | Won 4 |
| » W: Bill Wegman (2-5) L: Scott McGregor (5-5) | Fourth | 7½ out |
| Wednesday, June 11 |
| » Lost to Orioles (34-22), 4-3 | County Stadium (18-13) | 30-27 | |
| » W: Mike Boddicker (8-1) L: Danny Darwin (3-3) S: Don Aase (17) | Fourth | 8½ out |
| Friday, June 13 |
| » Lost to Red Sox (40-19), 5-3 | Fenway Park (0-1) | 30-28 | Lost 2 |
| » W: Oil Can Boyd (8-4) L: Teddy Higuera (8-5) S: Bob Stanley (11) | Fourth | 9½ out |
| Saturday, June 14 |
| » Defeated Red Sox (40-20), 2-0 | Fenway Park (1-1) | 31-28 | |
| » W: Tim Leary (5-5) L: Mike Brown (4-3) S: Dan Plesac (5) | Fourth | 8½ out |
| Sunday, June 15 |
| » Defeated Red Sox (40-21), 7-3 | Fenway Park (2-1) | 32-28 | Won 2 |
| » W: Juan Nieves (6-2) L: Jeff Sellers (0-2) S: Mark Clear (5) | Fourth | 7½ out |
| Monday, June 16 |
| » Lost to Blue Jays (32-32), 9-2 | County Stadium (18-14) | 32-29 | |
| » W: Doyle Alexander (5-3) L: Bill Wegman (2-6) S: Don Gordon (1) | Fourth | 8½ out |
| Tuesday, June 17 |
| » Lost to Blue Jays (33-32), 2-1 | County Stadium (18-15) | 32-30 | Lost 2 |
| » W: Tom Henke (6-3) L: Dan Plesac (4-4) | Fourth | 9½ out |
| Wednesday, June 18 |
| » Defeated Blue Jays (33-33), 3-1 | County Stadium (19-15) | 33-30 | |
| » W: Teddy Higuera (9-5) L: Jim Clancy (6-5) | Fourth | 9½ out |
| Friday, June 20 |
| » Defeated Tigers (31-33), 1-0 | County Stadium (20-15) | 34-30 | Won 2 |
| » W: Tim Leary (6-5) L: Walt Terrell (6-5) | Fourth | 8½ out |
| Saturday, June 21 |
| » Lost to Tigers (32-33), 4-3 | County Stadium (20-16) | 34-31 | |
| » W: Bill Campbell (1-1) L: Mark Clear (2-3) S: Guillermo Hernandez (13) | Fourth | 9½ out |
| Sunday, June 22 |
| » Defeated Tigers (32-34), 5-4 | County Stadium (21-16) | 35-31 | |
| » W: Bob Gibson (1-0) L: Dave LaPoint (2-6) | Fourth | 8½ out |
| Monday, June 23 |
| » Defeated Blue Jays (35-36), 5-3 | Exhibition Stadium (1-0) | 36-31 | Won 2 |
| » W: Danny Darwin (4-3) L: Dave Stieb (2-8) S: Dan Plesac (6) | Fourth | 7½ out |
| Tuesday, June 24 |
| » Lost to Blue Jays (36-36), 8-0 | Exhibition Stadium (1-1) | 36-32 | |
| » W: John Cerutti (2-1) L: Teddy Higuera (9-6) | Fourth | 7½ out |
| Wednesday, June 25 |
| » Lost to Blue Jays (37-36), 5-1 | Exhibition Stadium (1-2) | 36-33 | Lost 2 |
| » W: Jim Clancy (7-5) L: Tim Leary (6-6) S: Dennis Lamp (1) | Fourth | 8½ out |
| Friday, June 27 |
| » Lost to Tigers (35-35), 4-2 | Tiger Stadium (0-1) | 36-34 | Lost 3 |
| » W: Guillermo Hernandez (3-3) L: Dan Plesac (4-5) | Fifth | 9½ out |
| Saturday, June 28 |
| » Lost to Tigers (36-35), 8-5 | Tiger Stadium (0-2) | 36-35 | Lost 4 |
| » W: Bill Campbell (2-2) L: Bob Gibson (1-1) | Fifth | 10½ out |
| Sunday, June 29 |
| » Lost to Tigers (37-35), 9-5 | Tiger Stadium (0-3) | 36-36 | Lost 5 |
| » W: Eric King (4-0) L: Danny Darwin (4-4) S: Guillermo Hernandez (15) | Sixth | 11 out |
| » Defeated Tigers (37-36), 3-1 | Tiger Stadium (1-3) | 37-36 | |
| » W: Teddy Higuera (10-6) L: Jack Morris (7-5) S: Dan Plesac (7) | Sixth | 11 out |
| Monday, June 30 |
| » Lost to Orioles (39-35), 5-2 | Memorial Stadium (0-1) | 37-37 | |
| » W: Scott McGregor (6-7) L: Tim Leary (6-7) S: Don Aase (20) | Sixth | 12 out |
| Tuesday, July 1 |
| » Lost to Orioles (40-35), 7-3 | Memorial Stadium (0-2) | 37-38 | Lost 2 |
| » W: Mike Flanagan (2-5) L: Bill Wegman (2-7) S: Rich Bordi (3) | Sixth | 13 out |
| Wednesday, July 2 |
| » Defeated Orioles (40-36), 1-0 | Memorial Stadium (1-2) | 38-38 | |
| » W: Juan Nieves (7-2) L: Ken Dixon (6-7) | Sixth | 12 out |
| Friday, July 4 |
| » Defeated Athletics (30-51), 5-4 | County Stadium (22-16) | 39-38 | Won 2 |
| » W: Dan Plesac (5-5) L: Doug Bair (0-2) | Sixth | 11½ out |
| Saturday, July 5 |
| » Defeated Athletics (30-52), 2-1 | County Stadium (23-16) | 40-38 | Won 3 |
| » W: Danny Darwin (5-4) L: Eric Plunk (2-4) | Sixth | 10½ out |
| Sunday, July 6 |
| » Lost to Athletics (31-52), 6-3 | County Stadium (23-17) | 40-39 | |
| » W: Jose Rijo (3-7) L: Tim Leary (6-8) S: Steve Ontiveros (7) | Sixth | 11½ out |
| Monday, July 7 |
| » Lost to Angels (44-37), 3-1 | County Stadium (23-18) | 40-40 | Lost 2 |
| » W: Terry Forster (4-1) L: Dan Plesac (5-6) S: Doug Corbett (7) | Sixth | 11½ out |
| Tuesday, July 8 |
| » Lost to Angels (45-37), 14-3 | County Stadium (23-19) | 40-41 | Lost 3 |
| » W: John Candelaria (1-0) L: Juan Nieves (7-3) | Sixth | 12½ out |
| Wednesday, July 9 |
| » Lost to Angels (46-37), 6-1 | County Stadium (23-20) | 40-42 | Lost 4 |
| » W: Don Sutton (8-5) L: Teddy Higuera (10-7) S: Donnie Moore (8) | Seventh | 13½ out |
| Thursday, July 10 |
| » Lost to Mariners (37-50), 4-1 | County Stadium (23-21) | 40-43 | Lost 5 |
| » W: Steve Fireovid (2-0) L: Danny Darwin (5-5) S: Pete Ladd (5) | Seventh | 14½ out |
| Friday, July 11 |
| » Lost to Mariners (38-50), 9-3 | County Stadium (23-22) | 40-44 | Lost 6 |
| » W: Mike Morgan (7-8) L: Tim Leary (6-9) | Seventh | 14½ out |
| Saturday, July 12 |
| » Lost to Mariners (39-50), 15-9 | County Stadium (23-23) | 40-45 | Lost 7 |
| » W: Jerry Reed (1-0) L: Bill Wegman (2-8) S: Mark Huismann (4) | Seventh | 15½ out |
| Sunday, July 13 |
| » Defeated Mariners (39-51), 5-0 | County Stadium (24-23) | 41-45 | |
| » W: Juan Nieves (8-3) L: Mike Moore (5-9) | Seventh | 14½ out |
| Friday, July 18 |
| » Lost to Athletics (35-56), 6-1 | Oakland-Alameda County Stadium (0-3) | 41-46 | |
| » W: Joaquin Andujar (5-2) L: Juan Nieves (8-4) S: Steve Ontiveros (9) | Seventh | 14 out |
| » Major-league debuts: Glenn Braggs (Brewers) |
| Saturday, July 19 |
| » Lost to Athletics (36-56), 3-2 | Oakland-Alameda County Stadium (0-4) | 41-47 | Lost 2 |
| » W: Bill Mooneyham (3-3) L: Mark Clear (2-4) S: Doug Bair (3) | Seventh | 15 out |
| Sunday, July 20 |
| » Defeated Athletics (36-57), 7-2 | Oakland-Alameda County Stadium (1-4) | 42-47 | |
| » W: Teddy Higuera (11-7) L: Eric Plunk (2-6) | Seventh | 14½ out |
| » Lost to Athletics (37-57), 4-2 | Oakland-Alameda County Stadium (1-5) | 42-48 | |
| » W: Jose Rijo (4-8) L: Tim Leary (6-10) | Seventh | 14½ out |
| Monday, July 21 |
| » Defeated Angels (49-43), 5-3 | Anaheim Stadium (3-1) | 43-48 | |
| » W: Bill Wegman (3-8) L: Ron Romanick (5-8) S: Dan Plesac (8) | Seventh | 13½ out |
| Tuesday, July 22 |
| » Defeated Angels (49-44), 6-2 | Anaheim Stadium (4-1) | 44-48 | Won 2 |
| » W: Juan Nieves (9-4) L: Don Sutton (8-7) | Seventh | 12½ out |
| Wednesday, July 23 |
| » Lost to Angels (50-44), 3-2 | Anaheim Stadium (4-2) | 44-49 | |
| » W: Kirk McCaskill (11-6) L: Danny Darwin (5-6) | Seventh | 12½ out |
| Friday, July 25 |
| » Defeated Mariners (43-55), 4-2 | Kingdome (2-2) | 45-49 | |
| » W: Teddy Higuera (12-7) L: Mike Morgan (7-10) S: Mark Clear (6) | Seventh | 12½ out |
| Saturday, July 26 |
| » Lost to Mariners (44-55), 5-2 | Kingdome (2-3) | 45-50 | |
| » W: Jerry Reed (4-0) L: Bill Wegman (3-9) S: Matt Young (9) | Seventh | 12½ out |
| Sunday, July 27 |
| » Defeated Mariners (44-56), 8-1 | Kingdome (3-3) | 46-50 | |
| » W: Tim Leary (7-10) L: Mark Langston (9-7) | Seventh | 11½ out |
| Monday, July 28 |
| » Defeated Yankees (56-44), 5-4 | County Stadium (25-23) | 47-50 | Won 2 |
| » W: Juan Nieves (10-4) L: Joe Niekro (8-7) S: Dan Plesac (9) | Seventh | 11½ out |
| Tuesday, July 29 |
| » Defeated Yankees (56-45), 6-4 | County Stadium (26-23) | 48-50 | Won 3 |
| » W: Danny Darwin (6-6) L: Scott Nielsen (2-3) S: Mark Clear (7) | Seventh | 10½ out |
| Wednesday, July 30 |
| » Defeated Yankees (56-46), 5-0 | County Stadium (27-23) | 49-50 | Won 4 |
| » W: Teddy Higuera (13-7) L: Doug Drabek (2-4) | Seventh | 9½ out |
| Friday, August 1 |
| » Lost to Rangers (53-50), 7-2 | County Stadium (27-24) | 49-51 | |
| » W: Bobby Witt (6-9) L: Tim Leary (7-11) S: Dale Mohorcic (2) | Seventh | 11 out |
| » Lost to Rangers (54-50), 8-6 | County Stadium (27-25) | 49-52 | Lost 2 |
| » W: Ed Correa (7-9) L: Bob Gibson (1-2) S: Jeff Russell (1) | Seventh | 11 out |
| Saturday, August 2 |
| » Defeated Rangers (54-51), 9-8 | County Stadium (28-25) | 50-52 | |
| » W: Dan Plesac (6-6) L: Mitch Williams (7-3) S: Mark Clear (8) | Seventh | 10 out |
| Sunday, August 3 |
| » Lost to Rangers (55-51), 7-6 | County Stadium (28-26) | 50-53 | |
| » W: Jeff Russell (3-1) L: Danny Darwin (6-7) S: Dale Mohorcic (3) | Seventh | 11 out |
| » Major-league debuts: Chris Bosio (Brewers) |
| Monday, August 4 |
| » Defeated Yankees (58-49), 5-4 | Yankee Stadium (1-3) | 51-53 | |
| » W: Teddy Higuera (14-7) L: Doug Drabek (2-5) S: Mark Clear (9) | Seventh | 10 out |
| Tuesday, August 5 |
| » Defeated Yankees (58-50), 2-1 | Yankee Stadium (2-3) | 52-53 | Won 2 |
| » W: Dan Plesac (7-6) L: Dave Righetti (7-6) S: Mark Clear (10) | Seventh | 9 out |
| Wednesday, August 6 |
| » Lost to Yankees (59-50), 5-3 | Yankee Stadium (2-4) | 52-54 | |
| » W: Ron Guidry (6-9) L: Juan Nieves (10-5) S: Brian Fisher (6) | Seventh | 10 out |
| Thursday, August 7 |
| » Defeated Yankees (59-51), 10-2 | Yankee Stadium (3-4) | 53-54 | |
| » W: Tim Leary (8-11) L: Joe Niekro (8-8) S: John Henry Johnson (1) | Seventh | 9½ out |
| Friday, August 8 |
| » Lost to White Sox (49-58), 12-6 | County Stadium (28-27) | 53-55 | |
| » W: Joe Cowley (8-6) L: Danny Darwin (6-8) S: Gene Nelson (4) | Seventh | 10½ out |
| Saturday, August 9 |
| » Defeated White Sox (49-59), 1-0 | County Stadium (29-27) | 54-55 | |
| » W: Teddy Higuera (15-7) L: Jose DeLeon (3-4) | Seventh | 10½ out |
| Sunday, August 10 |
| » Defeated White Sox (49-60), 5-4 | County Stadium (30-27) | 55-55 | Won 2 |
| » W: Mark Clear (3-4) L: Dave J. Schmidt (0-4) | Seventh | 10½ out |
| Monday, August 11 |
| » Lost to White Sox (50-60), 6-1 | County Stadium (30-28) | 55-56 | |
| » W: Floyd Bannister (7-9) L: Chris Bosio (0-1) | Seventh | 10½ out |
| Tuesday, August 12 |
| » Defeated Rangers (59-54), 7-2 | Arlington Stadium (3-1) | 56-56 | |
| » W: Tim Leary (9-11) L: Charlie Hough (9-7) | Seventh | 9 out |
| Wednesday, August 13 |
| » Lost to Rangers (60-54), 5-4 | Arlington Stadium (3-2) | 56-57 | |
| » W: Greg Harris (8-8) L: John Henry Johnson (0-1) | Seventh | 10 out |
| Thursday, August 14 |
| » Lost to Rangers (61-54), 8-2 | Arlington Stadium (3-3) | 56-58 | Lost 2 |
| » W: Mike Loynd (2-0) L: Teddy Higuera (15-8) | Seventh | 11 out |
| Friday, August 15 |
| » Defeated White Sox (51-63), 4-3 | Comiskey Park I (4-0) | 57-58 | |
| » W: Dan Plesac (8-6) L: Bill Dawley (0-5) | Seventh | 11 out |
| Saturday, August 16 |
| » Defeated White Sox (51-64), 6-5 | Comiskey Park I (5-0) | 58-58 | Won 2 |
| » W: John Henry Johnson (1-1) L: Gene Nelson (5-5) S: Mark Clear (11) | Seventh | 10 out |
| Sunday, August 17 |
| » Lost to White Sox (52-64), 7-4 | Comiskey Park I (5-1) | 58-59 | |
| » W: Steve Carlton (6-12) L: Bryan Clutterbuck (0-1) S: Bobby Thigpen (1) | Sixth | 11 out |
| » Major-league debuts: Ron Karkovice (White Sox) Mike Birkbeck (Brewers) |
| Monday, August 18 |
| » Lost to Indians (62-57), 10-4 | Cleveland Stadium (1-3) | 58-60 | Lost 2 |
| » W: Tom Candiotti (12-9) L: Chris Bosio (0-2) | Sixth | 12 out |
| Tuesday, August 19 |
| » Defeated Indians (62-58), 5-3 | Cleveland Stadium (2-3) | 59-60 | |
| » W: Teddy Higuera (16-8) L: Jose Roman (1-2) S: Mark Clear (12) | Seventh | 11 out |
| Wednesday, August 20 |
| » Defeated Indians (62-59), 6-3 | Cleveland Stadium (3-3) | 60-60 | Won 2 |
| » W: Bill Wegman (4-9) L: Scott Bailes (9-8) S: Dan Plesac (10) | Seventh | 11 out |
| Friday, August 22 |
| » Lost to Royals (56-66), 4-2 | County Stadium (30-29) | 60-61 | |
| » W: Danny Jackson (9-8) L: Juan Nieves (10-6) S: Dan Quisenberry (11) | Seventh | 12½ out |
| Saturday, August 23 |
| » Defeated Royals (56-67), 8-4 | County Stadium (31-29) | 61-61 | |
| » W: Dan Plesac (9-6) L: Mark Gubicza (7-6) | Seventh | 11½ out |
| Sunday, August 24 |
| » Defeated Royals (56-68), 3-2 | County Stadium (32-29) | 62-61 | Won 2 |
| » W: Mark Clear (4-4) L: Dan Quisenberry (1-5) | Seventh | 10½ out |
| Tuesday, August 26 |
| » Defeated Twins (53-72), 6-5 | County Stadium (33-29) | 63-61 | Won 3 |
| » W: Mark Clear (5-4) L: Keith Atherton (5-9) | Seventh | 10 out |
| Wednesday, August 27 |
| » Lost to Twins (54-72), 7-5 | County Stadium (33-30) | 63-62 | |
| » W: Neal Heaton (5-12) L: Juan Nieves (10-7) S: George Frazier (3) | Seventh | 10 out |
| Thursday, August 28 |
| » Lost to Twins (55-72), 6-2 | County Stadium (33-31) | 63-63 | Lost 2 |
| » W: Bert Blyleven (14-10) L: Chris Bosio (0-3) | Sixth | 10½ out |
| Friday, August 29 |
| » Defeated Royals (58-70), 3-1 | Royals Stadium (3-1) | 64-63 | |
| » W: Teddy Higuera (17-8) L: Dennis Leonard (6-11) | Sixth | 9½ out |
| Saturday, August 30 |
| » Lost to Royals (59-70), 10-1 | Royals Stadium (3-2) | 64-64 | |
| » W: Mark Gubicza (8-6) L: Mike Birkbeck (0-1) | Sixth | 10½ out |
| Sunday, August 31 |
| » Lost to Royals (60-70), 6-1 | Royals Stadium (3-3) | 64-65 | Lost 2 |
| » W: Scott Bankhead (8-7) L: Bill Wegman (4-10) | Sixth | 11½ out |
| Monday, September 1 |
| » Lost to Twins (56-75), 9-3 | Hubert H. Humphrey Metrodome (1-3) | 64-66 | Lost 3 |
| » W: Neal Heaton (6-12) L: Juan Nieves (10-8) S: George Frazier (4) | Sixth | 12½ out |
| Tuesday, September 2 |
| » Lost to Twins (57-75), 4-0 | Hubert H. Humphrey Metrodome (1-4) | 64-67 | Lost 4 |
| » W: Bert Blyleven (15-10) L: Pete Vuckovich (0-1) | Seventh | 13½ out |
| Wednesday, September 3 |
| » Lost to Twins (58-75), 11-5 | Hubert H. Humphrey Metrodome (1-5) | 64-68 | Lost 5 |
| » W: Mike Smithson (10-12) L: Teddy Higuera (17-9) | Seventh | 14½ out |
| Thursday, September 4 |
| » Lost to Indians (67-68), 15-4 | County Stadium (33-32) | 64-69 | Lost 6 |
| » W: Scott Bailes (10-8) L: Tim Leary (9-12) | Seventh | 15 out |
| Friday, September 5 |
| » Lost to Indians (68-68), 13-5 | County Stadium (33-33) | 64-70 | Lost 7 |
| » W: Phil Niekro (11-10) L: Bill Wegman (4-11) | Seventh | 16 out |
| Saturday, September 6 |
| » Lost to Indians (69-68), 17-9 | County Stadium (33-34) | 64-71 | Lost 8 |
| » W: Greg Swindell (1-1) L: Juan Nieves (10-9) | Seventh | 17 out |
| Sunday, September 7 |
| » Defeated Indians (69-69), 7-2 | County Stadium (34-34) | 65-71 | |
| » W: Pete Vuckovich (1-1) L: Ken Schrom (12-7) S: Dan Plesac (11) | Seventh | 17 out |
| Tuesday, September 9 |
| » Defeated Tigers (71-68), 3-1 | Tiger Stadium (2-3) | 66-71 | Won 2 |
| » W: Teddy Higuera (18-9) L: Frank Tanana (10-7) S: Dan Plesac (12) | Seventh | 17½ out |
| Wednesday, September 10 |
| » Lost to Tigers (72-68), 11-7 | Tiger Stadium (2-4) | 66-72 | |
| » W: Walt Terrell (12-11) L: Chris Bosio (0-4) S: Mark Thurmond (2) | Seventh | 18½ out |
| Thursday, September 11 |
| » Lost to Tigers (73-68), 8-0 | Tiger Stadium (2-5) | 66-73 | Lost 2 |
| » W: Jack Morris (17-8) L: Juan Nieves (10-10) | Seventh | 18½ out |
| Friday, September 12 |
| » Defeated Blue Jays (76-65), 4-1 | County Stadium (35-34) | 67-73 | |
| » W: John Henry Johnson (2-1) L: Jim Clancy (14-10) S: Mark Clear (13) | Seventh | 18½ out |
| Saturday, September 13 |
| » Lost to Blue Jays (77-65), 7-1 | County Stadium (35-35) | 67-74 | |
| » W: Joe Johnson (11-9) L: Pete Vuckovich (1-2) S: Mark Eichhorn (9) | Seventh | 18½ out |
| Sunday, September 14 |
| » Defeated Blue Jays (77-66), 5-0 | County Stadium (36-35) | 68-74 | |
| » W: Teddy Higuera (19-9) L: Dave Stieb (5-11) | Fifth | 17½ out |
| Monday, September 15 |
| » Lost to Blue Jays (78-66), 5-2 | County Stadium (36-36) | 68-75 | |
| » W: John Cerutti (9-3) L: Bill Wegman (4-12) S: Tom Henke (21) | Fifth | 18 out |
| Tuesday, September 16 |
| » Lost to Red Sox (87-57), 2-1 | Fenway Park (2-2) | 68-76 | Lost 2 |
| » W: Roger Clemens (23-4) L: Juan Nieves (10-11) | Fifth | 20 out |
| » Lost to Red Sox (88-57), 9-3 | Fenway Park (2-3) | 68-77 | Lost 3 |
| » W: Calvin Schiraldi (4-1) L: Mark Clear (5-5) | Fifth | 20 out |
| Wednesday, September 17 |
| » Lost to Red Sox (89-57), 4-1 | Fenway Park (2-4) | 68-78 | Lost 4 |
| » W: Oil Can Boyd (15-9) L: Mark Knudson (1-6) | Sixth | 21 out |
| Thursday, September 18 |
| » Lost to Red Sox (90-57), 7-1 | Fenway Park (2-5) | 68-79 | Lost 5 |
| » W: Bruce Hurst (12-7) L: Pete Vuckovich (1-3) | Sixth | 22 out |
| Friday, September 19 |
| » Lost to Orioles (70-77), 3-1 | Memorial Stadium (1-3) | 68-80 | Lost 6 |
| » W: Ken Dixon (11-12) L: Teddy Higuera (19-10) | Seventh | 22 out |
| Saturday, September 20 |
| » Lost to Orioles (71-77), 4-3 | Memorial Stadium (1-4) | 68-81 | Lost 7 |
| » W: John Habyan (1-2) L: Dan Plesac (9-7) S: Don Aase (33) | Seventh | 22 out |
| Sunday, September 21 |
| » Defeated Orioles (71-78), 5-4 | Memorial Stadium (2-4) | 69-81 | |
| » W: Dan Plesac (10-7) L: Brad Havens (3-3) | Seventh | 22 out |
| Tuesday, September 23 |
| » Defeated Red Sox (91-60), 8-5 | County Stadium (37-36) | 70-81 | Won 2 |
| » W: Tim Leary (10-12) L: Oil Can Boyd (15-10) | Sixth | 21 out |
| Thursday, September 25 |
| » Defeated Orioles (71-82), 9-3 | County Stadium (38-36) | 71-81 | Won 3 |
| » W: Teddy Higuera (20-10) L: Ken Dixon (11-13) | Sixth | 20½ out |
| Friday, September 26 |
| » Defeated Orioles (71-83), 2-0 | County Stadium (39-36) | 72-81 | Won 4 |
| » Manager: Tom Trebelhorn |
| » W: Pete Vuckovich (2-3) L: Mike Boddicker ( |