| Monday, April 7 |
| » Major-league debuts: John Kruk (Padres) |
| Tuesday, April 8 |
| » Lost to Rangers (1-0), 6-3 | Arlington Stadium (0-1) | 0-1 | |
| » W: Jose Guzman (1-0) L: Dave Stieb (0-1) S: Greg Harris (1) | Second | 1 out |
| » Major-league debuts: Pete Incaviglia (Rangers) |
| Wednesday, April 9 |
| » Defeated Rangers (1-1), 3-1 | Arlington Stadium (1-1) | 1-1 | |
| » W: Doyle Alexander (1-0) L: Ed Correa (0-1) S: Tom Henke (1) | Second | 1 out |
| » Major-league debuts: Mitch Williams (Rangers) |
| Thursday, April 10 |
| » Defeated Rangers (1-2), 11-10 | Arlington Stadium (2-1) | 2-1 | Won 2 |
| » W: Tom Henke (1-0) L: Greg Harris (0-1) | Second | 1 out |
| » Major-league debuts: Bobby Witt (Rangers) Don Gordon (Blue Jays) |
| Friday, April 11 |
| » Defeated Royals (1-3), 6-2 | Royals Stadium (1-0) | 3-1 | Won 3 |
| » W: Jim Clancy (1-0) L: Mark Gubicza (0-1) | First | -- |
| Saturday, April 12 |
| » Lost to Royals (2-3), 1-0 | Royals Stadium (1-1) | 3-2 | |
| » W: Dennis Leonard (1-0) L: Jim Acker (0-1) | Second | 1 out |
| Sunday, April 13 |
| » Lost to Royals (3-3), 7-4 | Royals Stadium (1-2) | 3-3 | Lost 2 |
| » W: Buddy Black (1-1) L: Dave Stieb (0-2) S: Steve Farr (1) | Second | 2 out |
| Monday, April 14 |
| » Lost to Orioles (4-3), 2-1 | Exhibition Stadium (0-1) | 3-4 | Lost 3 |
| » W: Mike Boddicker (1-0) L: Doyle Alexander (1-1) | Fourth | 2½ out |
| Thursday, April 17 |
| » Lost to Orioles (5-3), 5-3 | Exhibition Stadium (0-2) | 3-5 | Lost 4 |
| » W: Mike Flanagan (1-1) L: Jimmy Key (0-1) S: Don Aase (2) | Fourth | 2½ out |
| » Defeated Orioles (5-4), 7-4 | Exhibition Stadium (1-2) | 4-5 | |
| » W: Tom Henke (2-0) L: Tippy Martinez (0-1) | Fourth | 2½ out |
| Friday, April 18 |
| » Lost to Royals (6-4), 6-4 | Exhibition Stadium (1-3) | 4-6 | |
| » W: Dennis Leonard (2-0) L: Dave Stieb (0-3) S: Dan Quisenberry (2) | Fifth | 2½ out |
| Saturday, April 19 |
| » Defeated Royals (6-5), 6-5 | Exhibition Stadium (2-3) | 5-6 | |
| » W: Doyle Alexander (2-1) L: Buddy Black (1-2) S: Tom Henke (2) | Fourth | 1½ out |
| Sunday, April 20 |
| » Lost to Royals (7-5), 6-4 | Exhibition Stadium (2-4) | 5-7 | |
| » W: Charlie Leibrandt (2-0) L: Dennis Lamp (0-1) S: Dan Quisenberry (3) | Sixth | 2½ out |
| Monday, April 21 |
| » Defeated Rangers (6-6), 7-6 | Exhibition Stadium (3-4) | 6-7 | |
| » W: Mark Eichhorn (1-0) L: Greg Harris (2-2) S: Tom Henke (3) | Fifth | 2½ out |
| Tuesday, April 22 |
| » Lost to Rangers (7-6), 10-1 | Exhibition Stadium (3-5) | 6-8 | |
| » W: Bobby Witt (1-0) L: Jim Clancy (1-1) S: Mickey Mahler (1) | Fifth | 3½ out |
| Wednesday, April 23 |
| » Lost to Rangers (8-6), 9-8 | Exhibition Stadium (3-6) | 6-9 | Lost 2 |
| » W: Mitch Williams (1-0) L: Dennis Lamp (0-2) S: Greg Harris (2) | Fifth | 4½ out |
| Friday, April 25 |
| » Defeated Orioles (8-8), 2-1 | Memorial Stadium (1-0) | 7-9 | |
| » W: Mark Eichhorn (2-0) L: Don Aase (1-2) | Fifth | 5 out |
| Saturday, April 26 |
| » Lost to Orioles (9-8), 11-5 | Memorial Stadium (1-1) | 7-10 | |
| » W: Brad Havens (1-1) L: Tom Henke (2-1) | Fifth | 5 out |
| Sunday, April 27 |
| » Defeated Orioles (9-9), 8-0 | Memorial Stadium (2-1) | 8-10 | |
| » W: Jim Clancy (2-1) L: Ken Dixon (2-1) | Fourth | 4 out |
| Tuesday, April 29 |
| » Lost to Angels (13-7), 4-3 | Exhibition Stadium (3-7) | 8-11 | |
| » W: Terry Forster (2-0) L: Mark Eichhorn (2-1) S: Donnie Moore (5) | Fifth | 5 out |
| Wednesday, April 30 |
| » Defeated Angels (13-8), 6-4 | Exhibition Stadium (4-7) | 9-11 | |
| » W: Doyle Alexander (3-1) L: Donnie Moore (1-1) | Sixth | 5 out |
| Thursday, May 1 |
| » Lost to Angels (14-8), 7-4 | Exhibition Stadium (4-8) | 9-12 | |
| » W: Jim Slaton (3-1) L: Jimmy Key (0-2) S: Donnie Moore (6) | Seventh | 5 out |
| Friday, May 2 |
| » Lost to Mariners (8-15), 3-2 | Exhibition Stadium (4-9) | 9-13 | Lost 2 |
| » W: Pete Ladd (2-1) L: Mark Eichhorn (2-2) | Sixth | 5 out |
| Saturday, May 3 |
| » Lost to Mariners (9-15), 4-2 | Exhibition Stadium (4-10) | 9-14 | Lost 3 |
| » W: Mike Morgan (2-2) L: Jim Acker (0-2) S: Pete Ladd (1) | Sixth | 6 out |
| Sunday, May 4 |
| » Defeated Mariners (9-16), 3-2 | Exhibition Stadium (5-10) | 10-14 | |
| » W: Tom Henke (3-1) L: Mike Moore (1-3) | Sixth | 5 out |
| Monday, May 5 |
| » Defeated Athletics (13-13), 10-6 | Exhibition Stadium (6-10) | 11-14 | Won 2 |
| » W: Mark Eichhorn (3-2) L: Bill Krueger (0-1) | Sixth | 5 out |
| Tuesday, May 6 |
| » Lost to Athletics (14-13), 17-3 | Exhibition Stadium (6-11) | 11-15 | |
| » W: Moose Haas (6-0) L: Jimmy Key (0-3) | Seventh | 6 out |
| Wednesday, May 7 |
| » Lost to Angels (16-12), 6-2 | Anaheim Stadium (0-1) | 11-16 | Lost 2 |
| » W: Don Sutton (1-3) L: Jim Clancy (2-2) S: Doug Corbett (2) | Seventh | 7 out |
| Thursday, May 8 |
| » Defeated Angels (16-13), 7-6 | Anaheim Stadium (1-1) | 12-16 | |
| » W: Mark Eichhorn (4-2) L: Terry Forster (3-1) S: Tom Henke (4) | Seventh | 6½ out |
| Friday, May 9 |
| » Lost to Mariners (10-20), 13-3 | Kingdome (0-1) | 12-17 | |
| » W: Mike Moore (2-3) L: Dave Stieb (0-4) | Seventh | 7 out |
| Saturday, May 10 |
| » Lost to Mariners (11-20), 8-7 | Kingdome (0-2) | 12-18 | Lost 2 |
| » W: Pete Ladd (3-1) L: Tom Henke (3-2) | Sixth | 8 out |
| Sunday, May 11 |
| » Defeated Mariners (11-21), 4-3 | Kingdome (1-2) | 13-18 | |
| » W: Jimmy Key (1-3) L: Bill Swift (0-3) S: Mark Eichhorn (1) | Sixth | 7½ out |
| Monday, May 12 |
| » Defeated Athletics (16-17), 5-3 | Oakland-Alameda County Stadium (1-0) | 14-18 | Won 2 |
| » W: Jim Clancy (3-2) L: Joaquin Andujar (4-2) S: Mark Eichhorn (2) | Sixth | 6½ out |
| Tuesday, May 13 |
| » Lost to Athletics (17-17), 6-3 | Oakland-Alameda County Stadium (1-1) | 14-19 | |
| » W: Bill Mooneyham (1-0) L: Dennis Lamp (0-3) | Seventh | 7½ out |
| Wednesday, May 14 |
| » Lost to Athletics (18-17), 9-4 | Oakland-Alameda County Stadium (1-2) | 14-20 | Lost 2 |
| » W: Curt Young (1-0) L: Dave Stieb (0-5) | Sixth | 7½ out |
| Thursday, May 15 |
| » Major-league debuts: Eric King (Tigers) |
| Friday, May 16 |
| » Defeated Indians (18-15), 7-6 | Exhibition Stadium (7-11) | 15-20 | |
| » W: Jim Acker (1-2) L: Tom Candiotti (2-4) S: Mark Eichhorn (3) | Fifth | 6½ out |
| Saturday, May 17 |
| » Defeated Indians (18-16), 11-5 | Exhibition Stadium (8-11) | 16-20 | Won 2 |
| » W: Jimmy Key (2-3) L: Neal Heaton (1-3) | Sixth | 6½ out |
| » Major-league debuts: Fred McGriff (Blue Jays) Reggie Ritter (Indians) |
| Sunday, May 18 |
| » Defeated Indians (18-17), 10-2 | Exhibition Stadium (9-11) | 17-20 | Won 3 |
| » W: Jim Clancy (4-2) L: Don Schulze (2-1) | Seventh | 6½ out |
| Monday, May 19 |
| » Lost to Indians (19-17), 6-4 | Exhibition Stadium (9-12) | 17-21 | |
| » W: Phil Niekro (3-3) L: Dave Stieb (0-6) S: Scott Bailes (3) | Seventh | 7½ out |
| Tuesday, May 20 |
| » Lost to White Sox (16-20), 2-1 | Comiskey Park I (0-1) | 17-22 | Lost 2 |
| » W: Joel Davis (2-1) L: John Cerutti (0-1) | Sixth | 8½ out |
| Wednesday, May 21 |
| » Lost to White Sox (17-20), 5-4 | Comiskey Park I (0-2) | 17-23 | Lost 3 |
| » W: Gene Nelson (4-1) L: Jim Acker (1-3) | Seventh | 9½ out |
| Thursday, May 22 |
| » Defeated White Sox (17-21), 5-0 | Comiskey Park I (1-2) | 18-23 | |
| » W: Jimmy Key (3-3) L: Richard Dotson (2-4) | Seventh | 9 out |
| Friday, May 23 |
| » Lost to Indians (22-18), 3-1 | Cleveland Stadium (0-1) | 18-24 | |
| » W: Don Schulze (3-1) L: Jim Clancy (4-3) | Seventh | 10 out |
| Saturday, May 24 |
| » Defeated Indians (22-19), 9-6 | Cleveland Stadium (1-1) | 19-24 | |
| » W: Dennis Lamp (1-3) L: Jamie Easterly (0-2) S: Mark Eichhorn (4) | Seventh | 9 out |
| Sunday, May 25 |
| » Defeated Indians (22-20), 8-1 | Cleveland Stadium (2-1) | 20-24 | Won 2 |
| » W: John Cerutti (1-1) L: Ken Schrom (3-2) | Seventh | 9 out |
| Monday, May 26 |
| » Lost to Twins (17-27), 9-1 | Hubert H. Humphrey Metrodome (0-1) | 20-25 | |
| » W: Mark Portugal (1-5) L: Doyle Alexander (3-2) | Seventh | 10 out |
| Tuesday, May 27 |
| » Lost to Twins (18-27), 7-6 | Hubert H. Humphrey Metrodome (0-2) | 20-26 | Lost 2 |
| » W: Frank Pastore (2-0) L: Tom Henke (3-3) | Seventh | 11 out |
| Wednesday, May 28 |
| » Defeated Twins (18-28), 14-8 | Hubert H. Humphrey Metrodome (1-2) | 21-26 | |
| » W: Jim Clancy (5-3) L: Bert Blyleven (4-4) | Seventh | 11 out |
| Thursday, May 29 |
| » Major-league debuts: Chuck Finley (Angels) |
| Friday, May 30 |
| » Defeated White Sox (18-27), 6-0 | Exhibition Stadium (10-12) | 22-26 | Won 2 |
| » W: Dave Stieb (1-6) L: Joel Davis (2-2) | Seventh | 10 out |
| Saturday, May 31 |
| » Defeated White Sox (18-28), 4-3 | Exhibition Stadium (11-12) | 23-26 | Won 3 |
| » W: Tom Henke (4-3) L: Gene Nelson (4-2) | Seventh | 10 out |
| Sunday, June 1 |
| » Lost to White Sox (19-28), 6-4 | Exhibition Stadium (11-13) | 23-27 | |
| » W: Richard Dotson (3-5) L: Jimmy Key (3-4) | Seventh | 11 out |
| Monday, June 2 |
| » Defeated Twins (19-31), 3-1 | Exhibition Stadium (12-13) | 24-27 | |
| » W: Jim Clancy (6-3) L: Bert Blyleven (4-5) S: Tom Henke (5) | Seventh | 11 out |
| Tuesday, June 3 |
| » Defeated Twins (19-32), 6-5 | Exhibition Stadium (13-13) | 25-27 | Won 2 |
| » W: Mark Eichhorn (5-2) L: Keith Atherton (2-3) S: Tom Henke (6) | Fifth | 11 out |
| Wednesday, June 4 |
| » Lost to Twins (20-32), 10-4 | Exhibition Stadium (13-14) | 25-28 | |
| » W: Frank Viola (5-5) L: Dave Stieb (1-7) | Sixth | 12 out |
| Friday, June 6 |
| » Defeated Tigers (24-26), 12-2 | Tiger Stadium (1-0) | 26-28 | |
| » W: Doyle Alexander (4-2) L: Walt Terrell (6-3) | Sixth | 11½ out |
| Saturday, June 7 |
| » Lost to Tigers (25-26), 2-1 | Tiger Stadium (1-1) | 26-29 | |
| » W: Frank Tanana (5-4) L: Jimmy Key (3-5) S: Guillermo Hernandez (9) | Sixth | 11½ out |
| Sunday, June 8 |
| » Defeated Tigers (25-27), 4-2 | Tiger Stadium (2-1) | 27-29 | |
| » W: Mark Eichhorn (6-2) L: Randy O'Neal (0-3) S: Tom Henke (7) | Fifth | 10½ out |
| Monday, June 9 |
| » Defeated Red Sox (37-19), 5-1 | Exhibition Stadium (14-14) | 28-29 | Won 2 |
| » W: Dave Stieb (2-7) L: Rob Woodward (1-2) | Sixth | 9½ out |
| Tuesday, June 10 |
| » Lost to Red Sox (38-19), 4-3 | Exhibition Stadium (14-15) | 28-30 | |
| » W: Bob Stanley (3-2) L: Mark Eichhorn (6-3) | Sixth | 10½ out |
| Wednesday, June 11 |
| » Lost to Red Sox (39-19), 3-2 | Exhibition Stadium (14-16) | 28-31 | Lost 2 |
| » W: Roger Clemens (11-0) L: Doyle Alexander (4-3) S: Bob Stanley (10) | Sixth | 11½ out |
| Thursday, June 12 |
| » Defeated Tigers (26-30), 9-0 | Exhibition Stadium (15-16) | 29-31 | |
| » W: Jimmy Key (4-5) L: Dave LaPoint (2-5) | Sixth | 11 out |
| Friday, June 13 |
| » Lost to Tigers (27-30), 10-5 | Exhibition Stadium (15-17) | 29-32 | |
| » W: Eric King (2-0) L: Jim Clancy (6-4) | Fifth | 12 out |
| Saturday, June 14 |
| » Defeated Tigers (27-31), 6-5 | Exhibition Stadium (16-17) | 30-32 | |
| » W: Tom Henke (5-3) L: Guillermo Hernandez (2-3) | Sixth | 11 out |
| Sunday, June 15 |
| » Defeated Tigers (27-32), 9-6 | Exhibition Stadium (17-17) | 31-32 | Won 2 |
| » W: Dennis Lamp (2-3) L: Chuck Cary (0-2) S: Tom Henke (8) | Sixth | 10 out |
| Monday, June 16 |
| » Defeated Brewers (32-29), 9-2 | County Stadium (1-0) | 32-32 | Won 3 |
| » W: Doyle Alexander (5-3) L: Bill Wegman (2-6) S: Don Gordon (1) | Sixth | 10 out |
| Tuesday, June 17 |
| » Defeated Brewers (32-30), 2-1 | County Stadium (2-0) | 33-32 | Won 4 |
| » W: Tom Henke (6-3) L: Dan Plesac (4-4) | Fifth | 10 out |
| Wednesday, June 18 |
| » Lost to Brewers (33-30), 3-1 | County Stadium (2-1) | 33-33 | |
| » W: Teddy Higuera (9-5) L: Jim Clancy (6-5) | Sixth | 11 out |
| Thursday, June 19 |
| » Defeated Yankees (37-29), 10-9 | Exhibition Stadium (18-17) | 34-33 | |
| » W: Bill Caudill (1-0) L: Dave Righetti (4-4) | Sixth | 10½ out |
| Friday, June 20 |
| » Lost to Yankees (38-29), 10-8 | Exhibition Stadium (18-18) | 34-34 | |
| » W: Brian Fisher (3-3) L: Don Gordon (0-1) | Sixth | 10½ out |
| Saturday, June 21 |
| » Lost to Yankees (39-29), 4-2 | Exhibition Stadium (18-19) | 34-35 | Lost 2 |
| » W: Dave Righetti (5-4) L: Dennis Lamp (2-4) S: Alfonso Pulido (1) | Sixth | 11½ out |
| Sunday, June 22 |
| » Defeated Yankees (39-30), 15-1 | Exhibition Stadium (19-19) | 35-35 | |
| » W: Jimmy Key (5-5) L: Joe Niekro (7-5) | Sixth | 10½ out |
| Monday, June 23 |
| » Lost to Brewers (36-31), 5-3 | Exhibition Stadium (19-20) | 35-36 | |
| » W: Danny Darwin (4-3) L: Dave Stieb (2-8) S: Dan Plesac (6) | Sixth | 10½ out |
| Tuesday, June 24 |
| » Defeated Brewers (36-32), 8-0 | Exhibition Stadium (20-20) | 36-36 | |
| » W: John Cerutti (2-1) L: Teddy Higuera (9-6) | Sixth | 9½ out |
| Wednesday, June 25 |
| » Defeated Brewers (36-33), 5-1 | Exhibition Stadium (21-20) | 37-36 | Won 2 |
| » W: Jim Clancy (7-5) L: Tim Leary (6-6) S: Dennis Lamp (1) | Fifth | 9½ out |
| Friday, June 27 |
| » Defeated Yankees (41-32), 14-7 | Yankee Stadium (1-0) | 38-36 | Won 3 |
| » W: Jim Acker (2-3) L: Brian Fisher (4-4) S: Tom Henke (9) | Fourth | 9½ out |
| Saturday, June 28 |
| » Defeated Yankees (41-33), 7-4 | Yankee Stadium (2-0) | 39-36 | Won 4 |
| » W: Jimmy Key (6-5) L: Joe Niekro (7-6) | Fourth | 9½ out |
| Sunday, June 29 |
| » Defeated Yankees (41-34), 6-3 | Yankee Stadium (3-0) | 40-36 | Won 5 |
| » W: John Cerutti (3-1) L: Brian Fisher (4-5) S: Tom Henke (10) | Third | 9½ out |
| Monday, June 30 |
| » Lost to Red Sox (49-25), 10-9 | Fenway Park (0-1) | 40-37 | |
| » W: Bob Stanley (5-2) L: Jim Acker (2-4) | Fifth | 10½ out |
| Tuesday, July 1 |
| » Lost to Red Sox (50-25), 9-7 | Fenway Park (0-2) | 40-38 | Lost 2 |
| » W: Tom Seaver (3-6) L: Doyle Alexander (5-4) S: Joe Sambito (7) | Fifth | 11½ out |
| Wednesday, July 2 |
| » Defeated Red Sox (50-26), 4-2 | Fenway Park (1-2) | 41-38 | |
| » W: Jimmy Key (7-5) L: Roger Clemens (14-1) S: Tom Henke (11) | Fifth | 10½ out |
| Thursday, July 3 |
| » Defeated Red Sox (50-27), 8-5 | Fenway Park (2-2) | 42-38 | Won 2 |
| » W: John Cerutti (4-1) L: Oil Can Boyd (10-6) S: Tom Henke (12) | Fourth | 9½ out |
| Friday, July 4 |
| » Lost to Angels (42-36), 9-1 | Exhibition Stadium (21-21) | 42-39 | |
| » W: Don Sutton (7-5) L: Dave Stieb (2-9) | Fifth | 10½ out |
| Saturday, July 5 |
| » Defeated Angels (42-37), 7-3 | Exhibition Stadium (22-21) | 43-39 | |
| » W: Jim Clancy (8-5) L: Ron Romanick (5-7) | Fourth | 9½ out |
| Sunday, July 6 |
| » Lost to Angels (43-37), 8-2 | Exhibition Stadium (22-22) | 43-40 | |
| » W: Kirk McCaskill (9-5) L: Dennis Lamp (2-5) | Fifth | 10½ out |
| Monday, July 7 |
| » Defeated Mariners (35-49), 7-5 | Exhibition Stadium (23-22) | 44-40 | |
| » W: Jimmy Key (8-5) L: Mike Morgan (6-8) S: Bill Caudill (1) | Fifth | 9½ out |
| Tuesday, July 8 |
| » Lost to Mariners (36-49), 8-5 | Exhibition Stadium (23-23) | 44-41 | |
| » W: Mark Huismann (2-2) L: John Cerutti (4-2) S: Matt Young (8) | Fifth | 10½ out |
| Wednesday, July 9 |
| » Defeated Mariners (36-50), 6-5 | Exhibition Stadium (24-23) | 45-41 | |
| » W: Bill Caudill (2-0) L: Mike Moore (5-8) S: Tom Henke (13) | Fifth | 10½ out |
| Thursday, July 10 |
| » Defeated Athletics (32-55), 8-4 | Exhibition Stadium (25-23) | 46-41 | Won 2 |
| » W: Jim Clancy (9-5) L: Eric Plunk (2-5) | Fifth | 10½ out |
| Friday, July 11 |
| » Defeated Athletics (32-56), 6-5 | Exhibition Stadium (26-23) | 47-41 | Won 3 |
| » W: Mark Eichhorn (7-3) L: Jose Rijo (3-8) S: Tom Henke (14) | Fifth | 9½ out |
| Saturday, July 12 |
| » Lost to Athletics (33-56), 5-3 | Exhibition Stadium (26-24) | 47-42 | |
| » W: Dave Stewart (2-0) L: Jimmy Key (8-6) S: Steve Ontiveros (8) | Fifth | 10½ out |
| Sunday, July 13 |
| » Lost to Athletics (34-56), 10-5 | Exhibition Stadium (26-25) | 47-43 | Lost 2 |
| » W: Curt Young (6-6) L: Bill Caudill (2-1) S: Dave Leiper (1) | Fifth | 10½ out |
| Thursday, July 17 |
| » Defeated Angels (48-40), 8-5 | Anaheim Stadium (2-1) | 48-43 | |
| » W: Jimmy Key (9-6) L: Don Sutton (8-6) S: John Cerutti (1) | Fifth | 9½ out |
| Friday, July 18 |
| » Defeated Angels (48-41), 2-0 | Anaheim Stadium (3-1) | 49-43 | Won 2 |
| » W: Jim Clancy (10-5) L: Kirk McCaskill (10-6) S: Mark Eichhorn (5) | Fourth | 8½ out |
| Saturday, July 19 |
| » Lost to Angels (49-41), 9-3 | Anaheim Stadium (3-2) | 49-44 | |
| » W: John Candelaria (3-0) L: Dave Stieb (2-10) | Fifth | 9½ out |
| Sunday, July 20 |
| » Defeated Angels (49-42), 6-3 | Anaheim Stadium (4-2) | 50-44 | |
| » W: Tom Henke (7-3) L: Doug Corbett (2-2) S: Bill Caudill (2) | Fifth | 8½ out |
| Monday, July 21 |
| » Defeated Mariners (42-53), 8-3 | Kingdome (2-2) | 51-44 | Won 2 |
| » W: John Cerutti (5-2) L: Mark Huismann (2-3) | Fourth | 7½ out |
| Tuesday, July 22 |
| » Lost to Mariners (43-53), 8-7 | Kingdome (2-3) | 51-45 | |
| » W: Jerry Reed (3-0) L: Bill Caudill (2-2) | Fifth | 7½ out |
| Wednesday, July 23 |
| » Defeated Mariners (43-54), 6-2 | Kingdome (3-3) | 52-45 | |
| » W: Jim Clancy (11-5) L: Mike Moore (6-10) S: Dave Stieb (1) | Fourth | 6½ out |
| Thursday, July 24 |
| » Major-league debuts: Mike Loynd (Rangers) |
| Friday, July 25 |
| » Lost to Athletics (41-57), 6-5 | Oakland-Alameda County Stadium (1-3) | 52-46 | |
| » W: Doug Bair (1-2) L: Bill Caudill (2-3) | Fifth | 7½ out |
| Saturday, July 26 |
| » Lost to Athletics (42-57), 2-0 | Oakland-Alameda County Stadium (1-4) | 52-47 | Lost 2 |
| » W: Eric Plunk (3-6) L: John Cerutti (5-3) S: Joaquin Andujar (1) | Sixth | 7½ out |
| Sunday, July 27 |
| » Lost to Athletics (43-57), 1-0 | Oakland-Alameda County Stadium (1-5) | 52-48 | Lost 3 |
| » W: Dave Leiper (1-1) L: Stan Clarke (0-1) | Fifth | 7½ out |
| Monday, July 28 |
| » Defeated Royals (46-54), 6-0 | Royals Stadium (2-2) | 53-48 | |
| » W: Jim Clancy (12-5) L: Charlie Leibrandt (9-7) | Fifth | 7½ out |
| Tuesday, July 29 |
| » Defeated Royals (46-55), 5-2 | Royals Stadium (3-2) | 54-48 | Won 2 |
| » W: Dave Stieb (3-10) L: Scott Bankhead (4-5) S: Tom Henke (15) | Sixth | 6½ out |
| Wednesday, July 30 |
| » Defeated Royals (46-56), 7-2 | Royals Stadium (4-2) | 55-48 | Won 3 |
| » W: Joe Johnson (7-7) L: Dennis Leonard (6-10) | Fifth | 5½ out |
| Friday, August 1 |
| » Lost to Orioles (56-46), 7-3 | Exhibition Stadium (26-26) | 55-49 | |
| » W: Ken Dixon (10-8) L: Jimmy Key (9-7) | Fifth | 6½ out |
| Saturday, August 2 |
| » Lost to Orioles (57-46), 5-2 | Exhibition Stadium (26-27) | 55-50 | Lost 2 |
| » W: Scott McGregor (8-10) L: Jim Clancy (12-6) S: Don Aase (28) | Sixth | 6½ out |
| Sunday, August 3 |
| » Defeated Orioles (57-47), 6-4 | Exhibition Stadium (27-27) | 56-50 | |
| » W: John Cerutti (6-3) L: Mike Flanagan (5-7) S: Tom Henke (16) | Fifth | 6½ out |
| Monday, August 4 |
| » Lost to Orioles (58-47), 12-2 | Exhibition Stadium (27-28) | 56-51 | |
| » W: Mike Boddicker (14-5) L: Joe Johnson (7-8) | Sixth | 6½ out |
| Tuesday, August 5 |
| » Lost to Royals (48-58), 8-6 | Exhibition Stadium (27-29) | 56-52 | Lost 2 |
| » W: Scott Bankhead (5-5) L: Dennis Lamp (2-6) S: Steve Farr (6) | Fifth | 6½ out |
| Wednesday, August 6 |
| » Defeated Royals (48-59), 8-0 | Exhibition Stadium (28-29) | 57-52 | |
| » W: Jimmy Key (10-7) L: Danny Jackson (6-8) | Fifth | 6½ out |
| Thursday, August 7 |
| » Defeated Royals (48-60), 5-4 | Exhibition Stadium (29-29) | 58-52 | Won 2 |
| » W: Mark Eichhorn (8-3) L: Steve Farr (7-3) S: Tom Henke (17) | Fifth | 6 out |
| Friday, August 8 |
| » Lost to Rangers (58-52), 9-7 | Arlington Stadium (2-2) | 58-53 | |
| » W: Greg Harris (6-8) L: Mark Eichhorn (8-4) | Fifth | 7 out |
| » Major-league debuts: Luis Aquino (Blue Jays) |
| Saturday, August 9 |
| » Lost to Rangers (59-52), 7-6 | Arlington Stadium (2-3) | 58-54 | Lost 2 |
| » W: Greg Harris (7-8) L: Bill Caudill (2-4) | Fifth | 8 out |
| Sunday, August 10 |
| » Defeated Rangers (59-53), 8-7 | Arlington Stadium (3-3) | 59-54 | |
| » W: Mark Eichhorn (9-4) L: Mitch Williams (8-4) | Sixth | 8 out |
| Monday, August 11 |
| » Lost to Orioles (60-52), 3-1 | Memorial Stadium (2-2) | 59-55 | |
| » W: Mike Flanagan (6-7) L: Jimmy Key (10-8) S: Don Aase (29) | Fifth | 8 out |
| Tuesday, August 12 |
| » Defeated Orioles (60-53), 3-0 | Memorial Stadium (3-2) | 60-55 | |
| » W: Jim Clancy (13-6) L: Scott McGregor (8-11) | Fifth | 6½ out |
| Wednesday, August 13 |
| » Lost to Orioles (61-53), 7-6 | Memorial Stadium (3-3) | 60-56 | |
| » W: Don Aase (5-3) L: Luis Aquino (0-1) | Fifth | 7½ out |
| Friday, August 15 |
| » Defeated Rangers (61-55), 6-1 | Exhibition Stadium (30-29) | 61-56 | |
| » W: Joe Johnson (8-8) L: Ed Correa (7-10) S: Mark Eichhorn (6) | Fifth | 8 out |
| Saturday, August 16 |
| » Defeated Rangers (61-56), 13-1 | Exhibition Stadium (31-29) | 62-56 | Won 2 |
| » W: Jimmy Key (11-8) L: Charlie Hough (9-8) | Fifth | 7 out |
| Sunday, August 17 |
| » Defeated Rangers (61-57), 8-7 | Exhibition Stadium (32-29) | 63-56 | Won 3 |
| » W: Mark Eichhorn (10-4) L: Jeff Russell (4-2) | Third | 7 out |
| Tuesday, August 19 |
| » Defeated White Sox (52-65), 5-1 | Exhibition Stadium (33-29) | 64-56 | Won 4 |
| » W: Dave Stieb (4-10) L: Joe Cowley (8-8) | Third | 6½ out |
| Wednesday, August 20 |
| » Defeated White Sox (52-66), 4-1 | Exhibition Stadium (34-29) | 65-56 | Won 5 |
| » W: Joe Johnson (9-8) L: Jose DeLeon (4-5) | Third | 6½ out |
| Thursday, August 21 |
| » Lost to White Sox (53-66), 4-3 | Exhibition Stadium (34-30) | 65-57 | |
| » W: Dave J. Schmidt (1-4) L: Jimmy Key (11-9) S: Gene Nelson (5) | Third | 7½ out |
| Friday, August 22 |
| » Lost to Twins (53-69), 4-3 | Hubert H. Humphrey Metrodome (1-3) | 65-58 | Lost 2 |
| » W: Bert Blyleven (13-10) L: Jim Clancy (13-7) S: George Frazier (2) | Fourth | 8½ out |
| Saturday, August 23 |
| » Defeated Twins (53-70), 7-4 | Hubert H. Humphrey Metrodome (2-3) | 66-58 | |
| » W: John Cerutti (7-3) L: Mike Smithson (9-12) S: Mark Eichhorn (7) | Fourth | 7½ out |
| Sunday, August 24 |
| » Defeated Twins (53-71), 7-5 | Hubert H. Humphrey Metrodome (3-3) | 67-58 | Won 2 |
| » W: Tom Henke (8-3) L: Keith Atherton (5-8) | Third | 6½ out |
| Tuesday, August 26 |
| » Tied Indians, 6-6 | Cleveland Stadium (2-1) | 67-58 | |
| » Starters: Joe Johnson vs Scott Bailes | Second | 6½ out |
| Wednesday, August 27 |
| » Defeated Indians (64-62), 3-2 | Cleveland Stadium (3-1) | 68-58 | Won 3 |
| » W: Mark Eichhorn (11-4) L: Bryan Oelkers (2-3) S: Tom Henke (18) | Second | 5 out |
| » Defeated Indians (64-63), 6-3 | Cleveland Stadium (4-1) | 69-58 | Won 4 |
| » W: John Cerutti (8-3) L: Frank Wills (1-2) S: Tom Henke (19) | Second | 5 out |
| Thursday, August 28 |
| » Defeated Indians (64-64), 9-1 | Cleveland Stadium (5-1) | 70-58 | Won 5 |
| » W: Jim Clancy (14-7) L: Ken Schrom (11-6) | Second | 4½ out |
| Friday, August 29 |
| » Defeated Twins (55-73), 6-5 | Exhibition Stadium (35-30) | 71-58 | Won 6 |
| » W: Mark Eichhorn (12-4) L: Keith Atherton (5-10) | Second | 3½ out |
| Saturday, August 30 |
| » Defeated Twins (55-74), 8-1 | Exhibition Stadium (36-30) | 72-58 | Won 7 |
| » W: Joe Johnson (10-8) L: Frank Viola (13-10) S: Dennis Lamp (2) | Second | 3½ out |
| Sunday, August 31 |
| » Defeated Twins (55-75), 7-5 | Exhibition Stadium (37-30) | 73-58 | Won 8 |
| » W: Luis Aquino (1-1) L: Allan Anderson (3-5) S: Mark Eichhorn (8) | Second | 3½ out |
| Monday, September 1 |
| » Defeated Indians (65-67), 5-4 | Exhibition Stadium (38-30) | 74-58 | Won 9 |
| » W: Tom Henke (9-3) L: Ernie Camacho (2-3) | Second | 3½ out |
| Tuesday, September 2 |
| » Lost to Indians (66-67), 9-5 | Exhibition Stadium (38-31) | 74-59 | |
| » W: Ken Schrom (12-6) L: Jim Clancy (14-8) S: Frank Wills (2) | Second | 4½ out |
| » Major-league debuts: Jeff Musselman (Blue Jays) |
| Wednesday, September 3 |
| » Defeated Indians (66-68), 3-1 | Exhibition Stadium (39-31) | 75-59 | |
| » W: Dave Stieb (5-10) L: Tom Candiotti (13-10) S: Tom Henke (20) | Second | 4½ out |
| » Major-league debuts: Dave Clark (Indians) |
| Friday, September 5 |
| » Lost to White Sox (59-75), 5-0 | Comiskey Park I (1-3) | 75-60 | |
| » W: Richard Dotson (10-13) L: Joe Johnson (10-9) | Second | 5½ out |
| Saturday, September 6 |
| » Defeated White Sox (59-76), 4-0 | Comiskey Park I (2-3) | 76-60 | |
| » W: Jimmy Key (12-9) L: Floyd Bannister (9-11) | Second | 5½ out |
| Sunday, September 7 |
| » Lost to White Sox (60-76), 4-3 | Comiskey Park I (2-4) | 76-61 | |
| » W: Gene Nelson (6-6) L: Jim Clancy (14-9) S: Bobby Thigpen (5) | Second | 6½ out |
| Tuesday, September 9 |
| » Lost to Yankees (73-65), 3-1 | Exhibition Stadium (39-32) | 76-62 | Lost 2 |
| » W: Ron Guidry (7-10) L: Mark Eichhorn (12-5) S: Dave Righetti (36) | Second | 8 out |
| Thursday, September 11 |
| » Lost to Yankees (74-65), 3-1 | Exhibition Stadium (39-33) | 76-63 | Lost 3 |
| » W: Doug Drabek (5-7) L: Jimmy Key (12-10) S: Dave Righetti (37) | Second | 9 out |
| » Lost to Yankees (75-65), 7-5 | Exhibition Stadium (39-34) | 76-64 | Lost 4 |
| » W: Brian Fisher (9-5) L: Tom Henke (9-4) S: Dave Righetti (38) | Second | 9 out |
| Friday, September 12 |
| » Lost to Brewers (67-73), 4-1 | County Stadium (2-2) | 76-65 | Lost 5 |
| » W: John Henry Johnson (2-1) L: Jim Clancy (14-10) S: Mark Clear (13) | Second | 10 out |
| Saturday, September 13 |
| » Defeated Brewers (67-74), 7-1 | County Stadium (3-2) | 77-65 | |
| » W: Joe Johnson (11-9) L: Pete Vuckovich (1-2) S: Mark Eichhorn (9) | Second | 9 out |
| Sunday, September 14 |
| » Lost to Brewers (68-74), 5-0 | County Stadium (3-3) | 77-66 | |
| » W: Teddy Higuera (19-9) L: Dave Stieb (5-11) | Second | 9 out |
| Monday, September 15 |
| » Defeated Brewers (68-75), 5-2 | County Stadium (4-3) | 78-66 | |
| » W: John Cerutti (9-3) L: Bill Wegman (4-12) S: Tom Henke (21) | Second | 8½ out |
| Tuesday, September 16 |
| » Defeated Tigers (76-69), 6-4 | Exhibition Stadium (40-34) | 79-66 | Won 2 |
| » W: Jimmy Key (13-10) L: Walt Terrell (12-12) S: Tom Henke (22) | Second | 9 out |
| Wednesday, September 17 |
| » Lost to Tigers (77-69), 8-6 | Exhibition Stadium (40-35) | 79-67 | |
| » W: Jack Morris (18-8) L: Jim Clancy (14-11) S: Guillermo Hernandez (22) | Second | 10 out |
| Friday, September 19 |
| » Defeated Red Sox (90-58), 6-4 | Exhibition Stadium (41-35) | 80-67 | |
| » W: Dave Stieb (6-11) L: Tom Seaver (7-13) S: Tom Henke (23) | Second | 9½ out |
| Saturday, September 20 |
| » Defeated Red Sox (90-59), 5-2 | Exhibition Stadium (42-35) | 81-67 | Won 2 |
| » W: Joe Johnson (12-9) L: Al Nipper (9-11) S: Mark Eichhorn (10) | Second | 8½ out |
| Sunday, September 21 |
| » Lost to Red Sox (91-59), 3-2 | Exhibition Stadium (42-36) | 81-68 | |
| » W: Roger Clemens (24-4) L: Jimmy Key (13-11) S: Calvin Schiraldi (9) | Second | 9½ out |
| Monday, September 22 |
| » Lost to Tigers (80-70), 2-1 | Tiger Stadium (2-2) | 81-69 | Lost 2 |
| » W: Jack Morris (19-8) L: Jim Clancy (14-12) | Second | 10 ou |