| Monday, April 7 |
| » Major-league debuts: John Kruk (Padres) |
| Tuesday, April 8 |
| » Lost to Giants (1-0), 8-3 | Astrodome (0-1) | 0-1 | |
| » W: Mike Krukow (1-0) L: Nolan Ryan (0-1) S: Mark Davis (1) | Third | 1 out |
| » Major-league debuts: Will Clark and Robby Thompson (Giants) |
| Wednesday, April 9 |
| » Lost to Giants (2-0), 4-1 | Astrodome (0-2) | 0-2 | Lost 2 |
| » W: Scott Garrelts (1-0) L: Mike Scott (0-1) S: Greg Minton (1) | Sixth | 2 out |
| Thursday, April 10 |
| » Defeated Giants (2-1), 4-0 | Astrodome (1-2) | 1-2 | |
| » W: Bob Knepper (1-0) L: Vida Blue (0-1) | Fourth | 1 out |
| Friday, April 11 |
| » Defeated Braves (1-2), 2-1 | Astrodome (2-2) | 2-2 | Won 2 |
| » W: Charlie Kerfeld (1-0) L: David Palmer (0-1) S: Dave Smith (1) | Third | 1 out |
| Saturday, April 12 |
| » Defeated Braves (1-3), 4-3 | Astrodome (3-2) | 3-2 | Won 3 |
| » W: Nolan Ryan (1-1) L: Rick Mahler (1-1) S: Dave Smith (2) | Second | 1 out |
| » Major-league debuts: Paul Assenmacher and Duane Ward (Braves) |
| Sunday, April 13 |
| » Lost to Braves (2-3), 8-7 | Astrodome (3-3) | 3-3 | |
| » W: Joe Johnson (1-0) L: Mike Scott (0-2) S: Gene Garber (1) | Third | 1 out |
| Tuesday, April 15 |
| » Defeated Giants (4-3), 8-3 | Candlestick Park (1-0) | 4-3 | |
| » W: Bob Knepper (2-0) L: Vida Blue (0-2) S: Charlie Kerfeld (1) | Second | 1 out |
| Wednesday, April 16 |
| » Defeated Giants (4-4), 4-1 | Candlestick Park (2-0) | 5-3 | Won 2 |
| » W: Nolan Ryan (2-1) L: Roger Mason (0-1) S: Dave Smith (3) | Second | 1 out |
| Friday, April 18 |
| » Defeated Reds (4-4), 6-4 | Riverfront Stadium (1-0) | 6-3 | Won 3 |
| » W: Mike Scott (1-2) L: Mario Soto (1-1) S: Dave Smith (4) | First | -- |
| Saturday, April 19 |
| » Defeated Reds (4-5), 4-3 | Riverfront Stadium (2-0) | 7-3 | Won 4 |
| » W: Bob Knepper (3-0) L: Tom Browning (0-1) S: Dave Smith (5) | First | -- |
| Sunday, April 20 |
| » Defeated Reds (4-6), 6-4 | Riverfront Stadium (3-0) | 8-3 | Won 5 |
| » W: Mike Madden (1-0) L: Bill Gullickson (0-1) S: Charlie Kerfeld (2) | First | -- |
| Monday, April 21 |
| » Lost to Braves (5-6), 8-2 | Atlanta-Fulton County Stadium (0-1) | 8-4 | |
| » W: Joe Johnson (2-0) L: Nolan Ryan (2-2) | Second | ½ out |
| Tuesday, April 22 |
| » Defeated Braves (5-7), 3-2 | Atlanta-Fulton County Stadium (1-1) | 9-4 | |
| » W: Charlie Kerfeld (2-0) L: Duane Ward (0-1) | Second | ½ out |
| Wednesday, April 23 |
| » Defeated Braves (5-8), 3-2 | Atlanta-Fulton County Stadium (2-1) | 10-4 | Won 2 |
| » W: Julio Solano (1-0) L: Zane Smith (1-1) S: Dave Smith (6) | First | -- |
| Thursday, April 24 |
| » Lost to Reds (5-7), 3-0 | Astrodome (3-4) | 10-5 | |
| » W: Mario Soto (2-1) L: Mike Madden (1-1) | First | -- |
| Friday, April 25 |
| » Defeated Reds (5-8), 3-1 | Astrodome (4-4) | 11-5 | |
| » W: Nolan Ryan (3-2) L: Tom Browning (0-2) | First | -- |
| Saturday, April 26 |
| » Defeated Reds (5-9), 1-0 | Astrodome (5-4) | 12-5 | Won 2 |
| » W: Mike Scott (2-2) L: Bill Gullickson (0-2) | First | -- |
| Sunday, April 27 |
| » Defeated Reds (5-10), 6-0 | Astrodome (6-4) | 13-5 | Won 3 |
| » W: Bob Knepper (4-0) L: John Denny (1-2) | First | -- |
| Tuesday, April 29 |
| » Lost to Phillies (8-8), 12-4 | Veteran's Stadium (0-1) | 13-6 | |
| » W: Shane Rawley (3-1) L: Nolan Ryan (3-3) | First | -- |
| Wednesday, April 30 |
| » Defeated Phillies (8-9), 1-0 | Veteran's Stadium (1-1) | 14-6 | |
| » W: Mike Scott (3-2) L: Kevin Gross (1-3) S: Dave Smith (7) | First | -- |
| Friday, May 2 |
| » Defeated Expos (9-10), 6-3 | Stade Olympique (1-0) | 15-6 | Won 2 |
| » W: Bob Knepper (5-0) L: Floyd Youmans (0-3) S: Dave Smith (8) | First | -- |
| Saturday, May 3 |
| » Lost to Expos (10-10), 7-6 | Stade Olympique (1-1) | 15-7 | |
| » W: Jeff Reardon (3-2) L: Frank DiPino (0-1) | First | -- |
| Sunday, May 4 |
| » Lost to Expos (11-10), 7-6 | Stade Olympique (1-2) | 15-8 | Lost 2 |
| » W: Jeff Reardon (4-2) L: Dave Smith (0-1) | First | -- |
| Tuesday, May 6 |
| » Lost to Mets (17-4), 4-0 | Shea Stadium (0-1) | 15-9 | Lost 3 |
| » W: Dwight Gooden (5-0) L: Bob Knepper (5-1) | First | -- |
| Wednesday, May 7 |
| » Lost to Mets (18-4), 3-2 | Shea Stadium (0-2) | 15-10 | Lost 4 |
| » W: Sid Fernandez (4-0) L: Nolan Ryan (3-4) S: Jesse Orosco (6) | Second | 1½ out |
| Friday, May 9 |
| » Defeated Pirates (11-13), 3-2 | Three Rivers Stadium (1-0) | 16-10 | |
| » W: Charlie Kerfeld (3-0) L: Jim Winn (1-1) S: Dave Smith (9) | First | -- |
| Saturday, May 10 |
| » Defeated Pirates (11-14), 6-3 | Three Rivers Stadium (2-0) | 17-10 | Won 2 |
| » W: Bob Knepper (6-1) L: Rick Rhoden (2-2) S: Frank DiPino (1) | First | -- |
| Sunday, May 11 |
| » Lost to Pirates (12-14), 4-3 | Three Rivers Stadium (2-1) | 17-11 | |
| » W: Jose DeLeon (1-0) L: Charlie Kerfeld (3-1) | First | -- |
| Monday, May 12 |
| » Lost to Phillies (12-15), 5-1 | Astrodome (6-5) | 17-12 | Lost 2 |
| » W: Shane Rawley (4-3) L: Jim Deshaies (0-1) | First | -- |
| Tuesday, May 13 |
| » Defeated Phillies (12-16), 3-2 | Astrodome (7-5) | 18-12 | |
| » W: Julio Solano (2-0) L: Dave Rucker (0-1) | First | -- |
| Wednesday, May 14 |
| » Defeated Mets (21-7), 6-2 | Astrodome (8-5) | 19-12 | Won 2 |
| » W: Bob Knepper (7-1) L: Bob Ojeda (5-1) | First | -- |
| Thursday, May 15 |
| » Lost to Mets (22-7), 6-2 | Astrodome (8-6) | 19-13 | |
| » W: Ron Darling (4-0) L: Nolan Ryan (3-5) | First | -- |
| Friday, May 16 |
| » Defeated Cubs (13-19), 9-6 | Astrodome (9-6) | 20-13 | |
| » W: Julio Solano (3-0) L: Jay Baller (1-2) S: Dave Smith (10) | First | -- |
| Saturday, May 17 |
| » Defeated Cubs (13-20), 5-1 | Astrodome (10-6) | 21-13 | Won 2 |
| » W: Mike Scott (4-2) L: Steve Trout (2-1) | First | -- |
| Sunday, May 18 |
| » Lost to Cubs (14-20), 5-2 | Astrodome (10-7) | 21-14 | |
| » W: Guy Hoffman (1-1) L: Bob Knepper (7-2) S: Lee Smith (5) | First | -- |
| Tuesday, May 20 |
| » Lost to Pirates (14-18), 4-2 | Astrodome (10-8) | 21-15 | Lost 2 |
| » W: Bob Walk (2-0) L: Nolan Ryan (3-6) | First | -- |
| Wednesday, May 21 |
| » Lost to Pirates (15-18), 2-1 | Astrodome (10-9) | 21-16 | Lost 3 |
| » W: Rick Rhoden (3-3) L: Mike Scott (4-3) | First | -- |
| Thursday, May 22 |
| » Defeated Pirates (15-19), 4-0 | Astrodome (11-9) | 22-16 | |
| » W: Bob Knepper (8-2) L: Rick Reuschel (3-4) | First | -- |
| Friday, May 23 |
| » Lost to Cubs (15-23), 4-1 | Wrigley Field (0-1) | 22-17 | |
| » W: Rick Sutcliffe (2-6) L: Julio Solano (3-1) | First | -- |
| Saturday, May 24 |
| » Lost to Cubs (16-23), 4-3 | Wrigley Field (0-2) | 22-18 | Lost 2 |
| » W: George Frazier (2-3) L: Dave Smith (0-2) S: Lee Smith (6) | First | -- |
| Sunday, May 25 |
| » Defeated Cubs (16-24), 3-1 | Wrigley Field (1-2) | 23-18 | |
| » W: Charlie Kerfeld (4-1) L: Lee Smith (2-4) S: Dave Smith (11) | First | -- |
| Monday, May 26 |
| » Defeated Cardinals (16-24), 4-1 | Busch Stadium II (1-0) | 24-18 | Won 2 |
| » W: Jim Deshaies (1-1) L: Bob Forsch (3-3) S: Frank DiPino (2) | First | -- |
| Tuesday, May 27 |
| » Defeated Cardinals (16-25), 5-4 | Busch Stadium II (2-0) | 25-18 | Won 3 |
| » W: Dave Smith (1-2) L: Ken Dayley (0-3) | First | -- |
| Wednesday, May 28 |
| » Defeated Cardinals (16-26), 4-3 | Busch Stadium II (3-0) | 26-18 | Won 4 |
| » W: Charlie Kerfeld (5-1) L: Todd Worrell (3-3) | First | -- |
| Thursday, May 29 |
| » Major-league debuts: Chuck Finley (Angels) |
| Friday, May 30 |
| » Lost to Expos (26-18), 1-0 | Astrodome (11-10) | 26-19 | |
| » W: Bryn Smith (4-4) L: Mike Scott (4-4) S: Jeff Reardon (12) | First | -- |
| Saturday, May 31 |
| » Defeated Expos (26-19), 4-3 | Astrodome (12-10) | 27-19 | |
| » W: Frank DiPino (1-1) L: Tim Burke (2-1) S: Dave Smith (12) | First | -- |
| Sunday, June 1 |
| » Defeated Expos (26-20), 8-4 | Astrodome (13-10) | 28-19 | Won 2 |
| » W: Bob Knepper (9-2) L: Joe Hesketh (3-4) | First | -- |
| Monday, June 2 |
| » Lost to Cardinals (19-27), 9-2 | Astrodome (13-11) | 28-20 | |
| » W: John Tudor (5-3) L: Mike Madden (1-2) | First | -- |
| Tuesday, June 3 |
| » Lost to Cardinals (20-27), 3-1 | Astrodome (13-12) | 28-21 | Lost 2 |
| » W: Greg Mathews (1-0) L: Jim Deshaies (1-2) S: Todd Worrell (8) | First | -- |
| » Major-league debuts: Greg Mathews (Cardinals) |
| Wednesday, June 4 |
| » Defeated Cardinals (20-28), 4-2 | Astrodome (14-12) | 29-21 | |
| » W: Mike Scott (5-4) L: Ray Burris (2-2) S: Dave Smith (13) | First | -- |
| Thursday, June 5 |
| » Lost to Dodgers (25-29), 1-0 | Dodger Stadium (0-1) | 29-22 | |
| » W: Rick Honeycutt (3-3) L: Manny Hernandez (0-1) S: Ken Howell (3) | First | -- |
| » Major-league debuts: Manny Hernandez (Astros) |
| Friday, June 6 |
| » Lost to Dodgers (26-29), 3-2 | Dodger Stadium (0-2) | 29-23 | Lost 2 |
| » W: Ken Howell (2-2) L: Bob Knepper (9-3) | First | -- |
| Saturday, June 7 |
| » Defeated Dodgers (26-30), 7-5 | Dodger Stadium (1-2) | 30-23 | |
| » W: Aurelio Lopez (1-0) L: Ken Howell (2-3) S: Dave Smith (14) | First | -- |
| Sunday, June 8 |
| » Defeated Dodgers (26-31), 3-2 | Dodger Stadium (2-2) | 31-23 | Won 2 |
| » W: Mike Scott (6-4) L: Fernando Valenzuela (8-4) S: Dave Smith (15) | First | -- |
| Monday, June 9 |
| » Defeated Padres (27-29), 5-3 | San Diego/Jack Murphy Stadium (1-0) | 32-23 | Won 3 |
| » W: Jim Deshaies (2-2) L: Eric Show (3-4) S: Aurelio Lopez (1) | First | -- |
| Tuesday, June 10 |
| » Defeated Padres (27-30), 12-1 | San Diego/Jack Murphy Stadium (2-0) | 33-23 | Won 4 |
| » W: Bob Knepper (10-3) L: Dave Dravecky (5-6) | First | -- |
| Wednesday, June 11 |
| » Lost to Padres (28-30), 11-7 | San Diego/Jack Murphy Stadium (2-1) | 33-24 | |
| » W: Lance McCullers (2-1) L: Frank DiPino (1-2) | First | -- |
| Thursday, June 12 |
| » Defeated Giants (31-27), 4-1 | Astrodome (15-12) | 34-24 | |
| » W: Manny Hernandez (1-1) L: Mike Krukow (8-4) S: Dave Smith (16) | First | -- |
| Friday, June 13 |
| » Lost to Giants (32-27), 3-1 | Astrodome (15-13) | 34-25 | |
| » W: Mark Davis (2-3) L: Mike Scott (6-5) | First | -- |
| Saturday, June 14 |
| » Defeated Giants (32-28), 7-3 | Astrodome (16-13) | 35-25 | |
| » W: Jim Deshaies (3-2) L: Terry Mulholland (0-1) S: Aurelio Lopez (2) | First | -- |
| Sunday, June 15 |
| » Lost to Giants (33-28), 7-2 | Astrodome (16-14) | 35-26 | |
| » W: Vida Blue (4-3) L: Bob Knepper (10-4) | First | -- |
| Tuesday, June 17 |
| » Lost to Reds (25-35), 5-4 | Riverfront Stadium (3-1) | 35-27 | Lost 2 |
| » W: Chris Welsh (2-1) L: Manny Hernandez (1-2) S: John Franco (11) | First | -- |
| Wednesday, June 18 |
| » Lost to Reds (26-35), 3-2 | Riverfront Stadium (3-2) | 35-28 | Lost 3 |
| » W: Ron Robinson (5-0) L: Dave Smith (1-3) | First | -- |
| Thursday, June 19 |
| » Defeated Reds (26-36), 6-2 | Riverfront Stadium (4-2) | 36-28 | |
| » W: Jim Deshaies (4-2) L: Mario Soto (3-7) | First | -- |
| Friday, June 20 |
| » Lost to Giants (35-31), 3-1 | Candlestick Park (2-1) | 36-29 | |
| » W: Vida Blue (5-3) L: Bob Knepper (10-5) S: Juan Berenguer (2) | First | -- |
| Saturday, June 21 |
| » Lost to Giants (36-31), 2-1 | Candlestick Park (2-2) | 36-30 | Lost 2 |
| » W: Scott Garrelts (6-6) L: Mark Knudson (0-1) S: Juan Berenguer (3) | First | -- |
| Sunday, June 22 |
| » Lost to Giants (37-31), 4-2 | Candlestick Park (2-3) | 36-31 | Lost 3 |
| » W: Mike Krukow (9-4) L: Manny Hernandez (1-3) | Second | 1½ out |
| » Lost to Giants (38-31), 3-2 | Candlestick Park (2-4) | 36-32 | Lost 4 |
| » W: Juan Berenguer (1-0) L: Dave Smith (1-4) S: Chuck Hensley (1) | Second | 1½ out |
| Monday, June 23 |
| » Defeated Reds (29-38), 7-6 | Astrodome (17-14) | 37-32 | |
| » W: Larry Andersen (1-0) L: Ted Power (3-5) | Second | 1½ out |
| Tuesday, June 24 |
| » Defeated Reds (29-39), 8-4 | Astrodome (18-14) | 38-32 | Won 2 |
| » W: Nolan Ryan (4-6) L: Tom Browning (5-7) | Second | ½ out |
| Wednesday, June 25 |
| » Lost to Reds (30-39), 4-3 | Astrodome (18-15) | 38-33 | |
| » W: John Franco (1-4) L: Aurelio Lopez (1-1) | Second | ½ out |
| Friday, June 27 |
| » Defeated Dodgers (34-39), 5-0 | Astrodome (19-15) | 39-33 | |
| » W: Mike Scott (7-5) L: Jerry Reuss (2-6) | Second | ½ out |
| Saturday, June 28 |
| » Defeated Dodgers (34-40), 6-4 | Astrodome (20-15) | 40-33 | Won 2 |
| » W: Jim Deshaies (5-2) L: Bob Welch (3-6) S: Aurelio Lopez (3) | Second | ½ out |
| » Major-league debuts: Jeff Hamilton (Dodgers) |
| Sunday, June 29 |
| » Defeated Dodgers (34-41), 2-1 | Astrodome (21-15) | 41-33 | Won 3 |
| » W: Manny Hernandez (2-3) L: Fernando Valenzuela (10-5) S: Frank DiPino (3) | First | -- |
| Monday, June 30 |
| » Lost to Padres (38-37), 9-2 | Astrodome (21-16) | 41-34 | |
| » W: Dave Dravecky (7-7) L: Bob Knepper (10-6) | First | -- |
| Tuesday, July 1 |
| » Lost to Padres (39-37), 7-4 | Astrodome (21-17) | 41-35 | Lost 2 |
| » W: Eric Show (7-4) L: Mark Knudson (0-2) S: Rich Gossage (14) | Second | ½ out |
| Wednesday, July 2 |
| » Defeated Padres (39-38), 8-1 | Astrodome (22-17) | 42-35 | |
| » W: Mike Scott (8-5) L: Andy Hawkins (5-5) | First | -- |
| Thursday, July 3 |
| » Lost to Mets (53-21), 6-5 | Shea Stadium (0-3) | 42-36 | |
| » W: Jesse Orosco (4-4) L: Frank DiPino (1-3) | Second | ½ out |
| Friday, July 4 |
| » Lost to Mets (54-21), 2-1 | Shea Stadium (0-4) | 42-37 | Lost 2 |
| » W: Dwight Gooden (10-3) L: Dave Smith (1-5) | Second | 1½ out |
| Saturday, July 5 |
| » Defeated Mets (54-22), 2-1 | Shea Stadium (1-4) | 43-37 | |
| » W: Charlie Kerfeld (6-1) L: Roger McDowell (7-1) | Second | ½ out |
| Sunday, July 6 |
| » Lost to Mets (55-22), 5-3 | Shea Stadium (1-5) | 43-38 | |
| » W: Sid Fernandez (11-2) L: Mark Knudson (0-3) S: Roger McDowell (8) | Second | 1½ out |
| Monday, July 7 |
| » Defeated Expos (44-35), 12-1 | Stade Olympique (2-2) | 44-38 | |
| » W: Mike Scott (9-5) L: Dennis Martinez (0-1) | Second | 1 out |
| Tuesday, July 8 |
| » Defeated Expos (44-36), 4-1 | Stade Olympique (3-2) | 45-38 | Won 2 |
| » W: Nolan Ryan (5-6) L: Jay Tibbs (4-5) S: Charlie Kerfeld (3) | First | -- |
| Wednesday, July 9 |
| » Lost to Expos (45-36), 2-1 | Stade Olympique (3-3) | 45-39 | |
| » W: Floyd Youmans (9-5) L: Bob Knepper (10-7) | First | -- |
| Thursday, July 10 |
| » Defeated Phillies (40-42), 11-4 | Astrodome (23-17) | 46-39 | |
| » W: Mark Knudson (1-3) L: Charles Hudson (4-9) | First | -- |
| Friday, July 11 |
| » Lost to Phillies (41-42), 4-1 | Astrodome (23-18) | 46-40 | |
| » W: Don Carman (4-2) L: Mike Scott (9-6) S: Steve Bedrosian (11) | First | -- |
| Saturday, July 12 |
| » Defeated Phillies (41-43), 4-3 | Astrodome (24-18) | 47-40 | |
| » W: Nolan Ryan (6-6) L: Shane Rawley (11-5) S: Dave Smith (17) | First | -- |
| Sunday, July 13 |
| » Lost to Phillies (42-43), 5-4 | Astrodome (24-19) | 47-41 | |
| » W: Steve Bedrosian (6-3) L: Dave Smith (1-6) | Second | 1 out |
| Thursday, July 17 |
| » Lost to Mets (60-25), 13-2 | Astrodome (24-20) | 47-42 | Lost 2 |
| » W: Bob Ojeda (11-2) L: Nolan Ryan (6-7) | Second | 2 out |
| Friday, July 18 |
| » Defeated Mets (60-26), 3-0 | Astrodome (25-20) | 48-42 | |
| » W: Bob Knepper (11-7) L: Ron Darling (9-3) | Second | 1 out |
| Saturday, July 19 |
| » Defeated Mets (60-27), 5-4 | Astrodome (26-20) | 49-42 | Won 2 |
| » W: Dave Smith (2-6) L: Roger McDowell (7-3) | First | -- |
| Sunday, July 20 |
| » Defeated Mets (60-28), 9-8 | Astrodome (27-20) | 50-42 | Won 3 |
| » W: Bob Knepper (12-7) L: Roger McDowell (7-4) | First | -- |
| Monday, July 21 |
| » Defeated Expos (48-40), 8-7 | Astrodome (28-20) | 51-42 | Won 4 |
| » W: Charlie Kerfeld (7-1) L: Jeff Reardon (6-5) | First | -- |
| Tuesday, July 22 |
| » Defeated Expos (48-41), 1-0 | Astrodome (29-20) | 52-42 | Won 5 |
| » W: Dave Smith (3-6) L: Floyd Youmans (10-6) | First | -- |
| Wednesday, July 23 |
| » Defeated Expos (48-42), 4-3 | Astrodome (30-20) | 53-42 | Won 6 |
| » W: Aurelio Lopez (2-1) L: Tim Burke (7-3) | First | -- |
| Thursday, July 24 |
| » Defeated Phillies (46-47), 9-3 | Veteran's Stadium (2-1) | 54-42 | Won 7 |
| » W: Mike Scott (10-6) L: Shane Rawley (11-7) | First | -- |
| Friday, July 25 |
| » Lost to Phillies (47-47), 4-2 | Veteran's Stadium (2-2) | 54-43 | |
| » W: Charles Hudson (6-9) L: Jim Deshaies (5-3) S: Steve Bedrosian (13) | First | -- |
| Saturday, July 26 |
| » Lost to Phillies (48-47), 3-2 | Veteran's Stadium (2-3) | 54-44 | Lost 2 |
| » W: Don Carman (5-2) L: Mark Knudson (1-4) S: Dan Schatzeder (2) | First | -- |
| Sunday, July 27 |
| » Defeated Phillies (48-48), 3-2 | Veteran's Stadium (3-3) | 55-44 | |
| » W: Nolan Ryan (7-7) L: Kevin Gross (6-8) S: Aurelio Lopez (4) | First | -- |
| Monday, July 28 |
| » Defeated Braves (45-53), 4-2 | Astrodome (31-20) | 56-44 | Won 2 |
| » W: Bob Knepper (13-7) L: Doyle Alexander (6-7) S: Dave Smith (18) | First | -- |
| Tuesday, July 29 |
| » Lost to Braves (46-53), 1-0 | Astrodome (31-21) | 56-45 | |
| » W: David Palmer (7-8) L: Mike Scott (10-7) S: Gene Garber (13) | First | -- |
| Wednesday, July 30 |
| » Defeated Braves (46-54), 4-2 | Astrodome (32-21) | 57-45 | |
| » W: Jim Deshaies (6-3) L: Jim Acker (3-5) S: Dave Smith (19) | First | -- |
| Friday, August 1 |
| » Defeated Padres (50-52), 6-3 | San Diego/Jack Murphy Stadium (3-1) | 58-45 | Won 2 |
| » W: Bob Knepper (14-7) L: LaMarr Hoyt (5-7) S: Dave Smith (20) | First | -- |
| Saturday, August 2 |
| » Defeated Padres (50-53), 5-4 | San Diego/Jack Murphy Stadium (4-1) | 59-45 | Won 3 |
| » W: Mike Scott (11-7) L: Eric Show (7-5) S: Dave Smith (21) | First | -- |
| Sunday, August 3 |
| » Lost to Padres (51-53), 5-1 | San Diego/Jack Murphy Stadium (4-2) | 59-46 | |
| » W: Andy Hawkins (8-7) L: Mark Knudson (1-5) S: Rich Gossage (18) | First | -- |
| Monday, August 4 |
| » Lost to Dodgers (53-52), 7-3 | Dodger Stadium (2-3) | 59-47 | Lost 2 |
| » W: Fernando Valenzuela (15-6) L: Charlie Kerfeld (7-2) | First | -- |
| Tuesday, August 5 |
| » Defeated Dodgers (53-53), 10-2 | Dodger Stadium (3-3) | 60-47 | |
| » W: Aurelio Lopez (3-1) L: Ken Howell (4-7) S: Dave Smith (22) | First | -- |
| Wednesday, August 6 |
| » Lost to Dodgers (54-53), 7-4 | Dodger Stadium (3-4) | 60-48 | |
| » W: Rick Honeycutt (8-6) L: Matt Keough (2-3) S: Tom Niedenfuer (7) | First | -- |
| Friday, August 8 |
| » Defeated Padres (51-57), 5-0 | Astrodome (33-21) | 61-48 | |
| » W: Mike Scott (12-7) L: Lance McCullers (5-6) | First | -- |
| Saturday, August 9 |
| » Defeated Padres (51-58), 6-2 | Astrodome (34-21) | 62-48 | Won 2 |
| » W: Jim Deshaies (7-3) L: Andy Hawkins (8-8) S: Charlie Kerfeld (4) | First | -- |
| Sunday, August 10 |
| » Lost to Padres (52-58), 5-3 | Astrodome (34-22) | 62-49 | |
| » W: Dave Dravecky (8-9) L: Bob Knepper (14-8) S: Rich Gossage (19) | First | -- |
| Monday, August 11 |
| » Defeated Dodgers (55-57), 7-6 | Astrodome (35-22) | 63-49 | |
| » W: Dave Smith (4-6) L: Ken Howell (4-8) | First | -- |
| Tuesday, August 12 |
| » Defeated Dodgers (55-58), 3-0 | Astrodome (36-22) | 64-49 | Won 2 |
| » W: Nolan Ryan (8-7) L: Rick Honeycutt (8-7) S: Charlie Kerfeld (5) | First | -- |
| Wednesday, August 13 |
| » Lost to Dodgers (56-58), 5-3 | Astrodome (36-23) | 64-50 | |
| » W: Orel Hershiser (12-8) L: Mike Scott (12-8) S: Tom Niedenfuer (8) | First | -- |
| Thursday, August 14 |
| » Defeated Dodgers (56-59), 3-2 | Astrodome (37-23) | 65-50 | |
| » W: Larry Andersen (2-0) L: Fernando Valenzuela (15-8) S: Dave Smith (23) | First | -- |
| Friday, August 15 |
| » Defeated Braves (54-61), 3-0 | Atlanta-Fulton County Stadium (3-1) | 66-50 | Won 2 |
| » W: Bob Knepper (15-8) L: Jim Acker (4-6) | First | -- |
| Saturday, August 16 |
| » Defeated Braves (54-62), 7-4 | Atlanta-Fulton County Stadium (4-1) | 67-50 | Won 3 |
| » W: Matt Keough (3-3) L: Rick Mahler (11-12) S: Dave Smith (24) | First | -- |
| Sunday, August 17 |
| » Lost to Braves (55-62), 4-3 | Atlanta-Fulton County Stadium (4-2) | 67-51 | |
| » W: Cliff Speck (2-0) L: Larry Andersen (2-1) S: Gene Garber (18) | First | -- |
| Monday, August 18 |
| » Defeated Pirates (47-71), 3-0 | Three Rivers Stadium (3-1) | 68-51 | |
| » W: Mike Scott (13-8) L: Bob Walk (5-7) | First | -- |
| Tuesday, August 19 |
| » Defeated Pirates (47-72), 1-0 | Three Rivers Stadium (4-1) | 69-51 | Won 2 |
| » W: Jim Deshaies (8-3) L: Mike Bielecki (6-9) S: Dave Smith (25) | First | -- |
| Wednesday, August 20 |
| » Lost to Pirates (48-72), 4-1 | Three Rivers Stadium (4-2) | 69-52 | |
| » W: Rick Rhoden (14-7) L: Bob Knepper (15-9) | First | -- |
| Friday, August 22 |
| » Lost to Cardinals (60-62), 6-5 | Busch Stadium II (3-1) | 69-53 | Lost 2 |
| » W: John Tudor (13-6) L: Nolan Ryan (8-8) S: Todd Worrell (28) | First | -- |
| Saturday, August 23 |
| » Lost to Cardinals (61-62), 7-1 | Busch Stadium II (3-2) | 69-54 | Lost 3 |
| » W: Danny Cox (8-10) L: Mike Scott (13-9) | First | -- |
| Sunday, August 24 |
| » Defeated Cardinals (61-63), 5-1 | Busch Stadium II (4-2) | 70-54 | |
| » W: Jim Deshaies (9-3) L: Tim Conroy (3-8) S: Aurelio Lopez (5) | First | -- |
| Monday, August 25 |
| » Defeated Cubs (53-72), 3-2 | Astrodome (38-23) | 71-54 | Won 2 |
| » W: Charlie Kerfeld (8-2) L: Lee Smith (8-8) S: Dave Smith (26) | First | -- |
| Tuesday, August 26 |
| » Lost to Cubs (54-72), 5-3 | Astrodome (38-24) | 71-55 | |
| » W: Ed Lynch (4-3) L: Danny Darwin (6-9) S: Lee Smith (25) | First | -- |
| Wednesday, August 27 |
| » Defeated Cubs (54-73), 7-1 | Astrodome (39-24) | 72-55 | |
| » W: Nolan Ryan (9-8) L: Jamie Moyer (5-4) S: Charlie Kerfeld (6) | First | -- |
| Friday, August 29 |
| » Defeated Pirates (51-76), 3-2 | Astrodome (40-24) | 73-55 | Won 2 |
| » W: Mike Scott (14-9) L: Rick Reuschel (8-15) S: Dave Smith (27) | First | -- |
| Saturday, August 30 |
| » Lost to Pirates (52-76), 13-3 | Astrodome (40-25) | 73-56 | |
| » W: Rick Rhoden (15-7) L: Jim Deshaies (9-4) | First | -- |
| Sunday, August 31 |
| » Lost to Pirates (53-76), 8-2 | Astrodome (40-26) | 73-57 | Lost 2 |
| » W: Bob Walk (7-7) L: Bob Knepper (15-10) | First | -- |
| Monday, September 1 |
| » Defeated Cubs (55-76), 6-4 | Wrigley Field (2-2) | 74-57 | |
| » W: Danny Darwin (7-9) L: Ed Lynch (4-4) S: Dave Smith (28) | First | -- |
| Wednesday, September 3 |
| » Defeated Cubs (55-77), 8-7 | Wrigley Field (3-2) | 75-57 | Won 2 |
| » W: Danny Darwin (8-9) L: Greg Maddux (0-1) | First | -- |
| » Defeated Cubs (55-78), 8-2 | Wrigley Field (4-2) | 76-57 | Won 3 |
| » W: Mike Scott (15-9) L: Scott Sanderson (7-11) | First | -- |
| » Major-league debuts: Greg Maddux (Cubs) |
| Friday, September 5 |
| » Lost to Cardinals (68-66), 8-5 | Astrodome (40-27) | 76-58 | |
| » W: Ray Soff (2-0) L: Aurelio Lopez (3-2) | First | -- |
| Saturday, September 6 |
| » Defeated Cardinals (68-67), 7-6 | Astrodome (41-27) | 77-58 | |
| » W: Charlie Kerfeld (9-2) L: Todd Worrell (8-10) | First | -- |
| Sunday, September 7 |
| » Defeated Cardinals (68-68), 6-3 | Astrodome (42-27) | 78-58 | Won 2 |
| » W: Jeff Calhoun (1-0) L: Greg Mathews (10-5) S: Dave Smith (29) | First | -- |
| Monday, September 8 |
| » Defeated Reds (70-67), 3-1 | Astrodome (43-27) | 79-58 | Won 3 |
| » W: Nolan Ryan (10-8) L: Chris Welsh (5-6) S: Charlie Kerfeld (7) | First | -- |
| Tuesday, September 9 |
| » Defeated Reds (70-68), 9-2 | Astrodome (44-27) | 80-58 | Won 4 |
| » W: Mike Scott (16-9) L: Tom Browning (12-12) | First | -- |
| Wednesday, September 10 |
| » Lost to Dodgers (67-72), 5-1 | Dodger Stadium (3-5) | 80-59 | |
| » W: Orel Hershiser (13-11) L: Jim Deshaies (9-5) | First | -- |
| Thursday, September 11 |
| » Lost to Dodgers (68-72), 14-6 | Dodger Stadium (3-6) | 80-60 | Lost 2 |
| » W: Fernando Valenzuela (19-9) L: Bob Knepper (15-11) | First | -- |
| Friday, September 12 |
| » Defeated Padres (65-77), 5-3 | San Diego/Jack Murphy Stadium (5-2) | 81-60 | |
| » W: Charlie Kerfeld (10-2) L: Lance McCullers (8-8) S: Dave Smith (30) | First | -- |
| Saturday, September 13 |
| » Lost to Padres (66-77), 4-3 | San Diego/Jack Murphy Stadium (5-3) | 81-61 | |
| » W: Craig Lefferts (8-7) L: Dave Smith (4-7) | First | -- |
| Sunday, September 14 |
| » Lost to Padres (67-77), 3-2 | San Diego/Jack Murphy Stadium (5-4) | 81-62 | Lost 2 |
| » W: Craig Lefferts (9-7) L: Mike Scott (16-10) | First | -- |
| » Major-league debuts: Gary Green and Benito Santiago (Padres) |
| Tuesday, September 16 |
| » Defeated Reds (74-70), 6-1 | Riverfront Stadium (5-2) | 82-62 | |
| » W: Bob Knepper (16-11) L: Bill Gullickson (13-11) S: Larry Andersen (1) | First | -- |
| Wednesday, September 17 |
| » Defeated Reds (74-71), 6-1 | Riverfront Stadium (6-2) | 83-62 | Won 2 |
| » W: Danny Darwin (9-9) L: Chris Welsh (6-7) | First | -- |
| Thursday, September 18 |
| » Defeated Reds (74-72), 5-3 | Riverfront Stadium (7-2) | 84-62 | Won 3 |
| » W: Matt Keough (4-3) L: Tom Browning (13-13) S: Aurelio Lopez (6) | First | -- |
| Friday, September 19 |
| » Defeated Padres (68-79), 5-4 | Astrodome (45-27) | 85-62 | Won 4 |
| » W: Charlie Kerfeld (11-2) L: Dave LaPoint (4-9) S: Dave Smith (31) | First | -- |
| Saturday, September 20 |
| » Defeated Padres (68-80), 10-6 | Astrodome (46-27) | 86-62 | Won 5 |
| » W: Mike Scott (17-10) L: Ray Hayward (0-1) | First | -- |
| » Major-league debuts: Mark Parent (Padres) |
| Sunday, September 21 |
| » Lost to Padres (69-80), 5-0 | Astrodome (46-28) | 86-63 | |
| » W: Jimmy Jones (1-0) L: Bob Knepper (16-12) | First | -- |
| » Major-league debuts: Jimmy Jones (Padres) |
| Monday, September 22 |
| » Lost to Dodgers (70-80), 9-2 | Astrodome (46-29) | 86-64 | Lost 2 |
| » W: Fernando Valenzuela (20-10) L: Danny Darwin (9-10) | First | -- |
| Tuesday, September 23 |
| » Defeated Dodgers (70-81), 4-0 | Astrodome (47-29) | 87-64 | |
| » W: Jim Deshaies (10-5) L: Dennis Powell (2-7) | First | -- |
| Wednesday, September 24 |
| » Defeated Giants (77-75), 6-0 | Astrodome (48-29) | 88-64 | Won 2 |
| » W: Nolan Ryan (11-8) L: Mike LaCoss (10-13) | First | -- |
| Thursday, September 25 |
| » Defeated Giants (77-76), 2-0 | Astrodome (49-29) | 89-64 | Won 3 |
| » W: Mike Scott (18-10) L: Juan Berenguer (2-3) | First | -- |
| Friday, September 26 |
| » Lost to Braves (71-82), 5-4 | Atlanta-Fulton County Stadium (4-3) | 89-65 | |
| » W: Doyle Alexander (11-10) L: Matt Keough (4- |
