| Sunday, March 10 |
| Former White Sox Bob Nieman dies in Corona, CA at the age of 59. |
| Sunday, March 17 |
| Former White Sox Ike Pearson dies in Sarasota, FL at the age of 69. |
| Monday, April 8 |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Tuesday, April 9 |
| » Defeated Brewers (0-1), 4-2 | County Stadium (1-0) | 1-0 | |
| » W: Tom Seaver (1-0) L: Moose Haas (0-1) S: Bob James (1) | First | -- |
| » Major-league debuts: Ozzie Guillen (White Sox) |
| Thursday, April 11 |
| » Lost to Brewers (1-1), 8-1 | County Stadium (1-1) | 1-1 | |
| » W: Ray Burris (1-0) L: Tim Lollar (0-1) | Third | 1½ out |
| Saturday, April 13 |
| » Lost to Red Sox (4-0), 7-2 | Fenway Park (0-1) | 1-2 | Lost 2 |
| » W: Oil Can Boyd (2-0) L: Floyd Bannister (0-1) | Third | 3 out |
| Sunday, April 14 |
| » Defeated Red Sox (4-1), 11-6 | Fenway Park (1-1) | 2-2 | |
| » W: Britt Burns (1-0) L: Steve Crawford (0-1) | Second | 3 out |
| » Major-league debuts: Mike Trujillo (Red Sox) |
| Monday, April 15 |
| » Defeated Red Sox (4-2), 6-5 | Fenway Park (2-1) | 3-2 | Won 2 |
| » W: Al Jones (1-0) L: Bob Stanley (0-1) | Second | 2 out |
| » Major-league debuts: Steve Lyons (Red Sox) |
| Tuesday, April 16 |
| » Lost to Yankees (3-3), 5-4 | Yankee Stadium (0-1) | 3-3 | |
| » W: Dave Righetti (1-0) L: Dan Spillner (0-1) | Second | 2 out |
| Thursday, April 18 |
| » Lost to Yankees (4-3), 3-2 | Yankee Stadium (0-2) | 3-4 | Lost 2 |
| » W: Rich Bordi (1-0) L: Floyd Bannister (0-2) S: Dave Righetti (3) | Third | 2 out |
| Friday, April 19 |
| » Defeated Red Sox (5-5), 8-1 | Comiskey Park I (1-0) | 4-4 | |
| » W: Britt Burns (2-0) L: Mike Trujillo (0-1) | Second | 1 out |
| Saturday, April 20 |
| » Lost to Red Sox (6-5), 12-8 | Comiskey Park I (1-1) | 4-5 | |
| » W: Steve Crawford (1-1) L: Gene Nelson (0-1) S: Bob Stanley (2) | Third | 2 out |
| Sunday, April 21 |
| » Defeated Red Sox (6-6), 7-2 | Comiskey Park I (2-1) | 5-5 | |
| » W: Tim Lollar (1-1) L: Roger Clemens (1-2) | Second | 1 out |
| Monday, April 22 |
| » Lost to Brewers (6-5), 4-2 | Comiskey Park I (2-2) | 5-6 | |
| » W: Danny Darwin (2-0) L: Juan Agosto (0-1) S: Rollie Fingers (2) | Fourth | 2 out |
| Tuesday, April 23 |
| » Defeated Brewers (6-6), 6-5 | Comiskey Park I (3-2) | 6-6 | |
| » W: Bob James (1-0) L: Rollie Fingers (0-1) | Third | 1 out |
| » Major-league debuts: Ted Higuera (Brewers) |
| Wednesday, April 24 |
| » Lost to Brewers (7-6), 3-2 | Comiskey Park I (3-3) | 6-7 | |
| » W: Pete Vuckovich (1-0) L: Britt Burns (2-1) S: Ray Searage (1) | Fifth | 2 out |
| Friday, April 26 |
| » Defeated Yankees (6-8), 4-2 | Comiskey Park I (4-3) | 7-7 | |
| » W: Tom Seaver (2-0) L: Ed Whitson (0-3) S: Bob James (2) | Third | 1½ out |
| Saturday, April 27 |
| » Defeated Yankees (6-9), 5-4 | Comiskey Park I (5-3) | 8-7 | Won 2 |
| » W: Gene Nelson (1-1) L: Bob Shirley (0-1) | Second | 1½ out |
| Sunday, April 28 |
| » Defeated Yankees (6-10), 4-3 | Comiskey Park I (6-3) | 9-7 | Won 3 |
| » W: Britt Burns (3-1) L: Joe Cowley (0-1) | Second | 1½ out |
| Tuesday, April 30 |
| » Lost to Orioles (12-7), 9-7 | Memorial Stadium (0-1) | 9-8 | |
| » W: Mike Boddicker (3-1) L: Floyd Bannister (0-3) S: Sammy Stewart (4) | Fourth | 3 out |
| Wednesday, May 1 |
| » Lost to Orioles (13-7), 3-1 | Memorial Stadium (0-2) | 9-9 | Lost 2 |
| » W: Ken Dixon (2-0) L: Britt Burns (3-2) S: Don Aase (1) | Fourth | 3 out |
| Friday, May 3 |
| » Defeated Tigers (11-9), 7-1 | Tiger Stadium (1-0) | 10-9 | |
| » W: Tom Seaver (3-0) L: Dan Petry (4-2) | Third | 2½ out |
| Saturday, May 4 |
| » Lost to Tigers (12-9), 7-1 | Tiger Stadium (1-1) | 10-10 | |
| » W: Walt Terrell (3-0) L: Tim Lollar (1-2) | Third | 3½ out |
| Sunday, May 5 |
| » Lost to Tigers (13-9), 4-3 | Tiger Stadium (1-2) | 10-11 | Lost 2 |
| » W: Juan Berenguer (1-1) L: Richard Dotson (0-1) S: Willie Hernandez (5) | Fourth | 4½ out |
| Tuesday, May 7 |
| » Defeated Indians (10-15), 7-4 | Cleveland Stadium (1-0) | 11-11 | |
| » W: Floyd Bannister (1-3) L: Bert Blyleven (1-3) S: Bob James (3) | Third | 3½ out |
| Wednesday, May 8 |
| » Defeated Indians (10-16), 4-0 | Cleveland Stadium (2-0) | 12-11 | Won 2 |
| » W: Britt Burns (4-2) L: Neal Heaton (2-2) | Third | 2½ out |
| Friday, May 10 |
| » Lost to Tigers (16-9), 3-1 | Comiskey Park I (6-4) | 12-12 | |
| » W: Walt Terrell (4-0) L: Tom Seaver (3-1) S: Willie Hernandez (7) | Third | 3½ out |
| Saturday, May 11 |
| » Defeated Tigers (16-10), 7-4 | Comiskey Park I (7-4) | 13-12 | |
| » W: Richard Dotson (1-1) L: Juan Berenguer (1-2) S: Bob James (4) | Third | 3½ out |
| Sunday, May 12 |
| » Defeated Tigers (16-11), 4-0 | Comiskey Park I (8-4) | 14-12 | Won 2 |
| » W: Floyd Bannister (2-3) L: Jack Morris (4-4) | Third | 2½ out |
| Monday, May 13 |
| » Defeated Indians (12-18), 8-0 | Comiskey Park I (9-4) | 15-12 | Won 3 |
| » W: Britt Burns (5-2) L: Neal Heaton (2-3) | Second | 2 out |
| Tuesday, May 14 |
| » Defeated Indians (12-19), 2-1 | Comiskey Park I (10-4) | 16-12 | Won 4 |
| » W: Gene Nelson (2-1) L: Rich Thompson (0-1) S: Bob James (5) | Second | 2 out |
| Former White Sox Harry Byrd dies in Darlington, SC at the age of 61. |
| Wednesday, May 15 |
| » Defeated Orioles (18-13), 5-2 | Comiskey Park I (11-4) | 17-12 | Won 5 |
| » W: Tom Seaver (4-1) L: Don Aase (4-1) S: Bob James (6) | Second | 2 out |
| Thursday, May 16 |
| » Lost to Orioles (19-13), 3-1 | Comiskey Park I (11-5) | 17-13 | |
| » W: Mike Boddicker (6-1) L: Floyd Bannister (2-4) | Second | 1½ out |
| Friday, May 17 |
| » Defeated Rangers (9-24), 4-2 | Comiskey Park I (12-5) | 18-13 | |
| » W: Richard Dotson (2-1) L: Dickie Noles (2-4) S: Bob James (7) | Second | 1½ out |
| Saturday, May 18 |
| » Lost to Rangers (10-24), 7-2 | Comiskey Park I (12-6) | 18-14 | |
| » W: Burt Hooton (1-1) L: Britt Burns (5-3) S: Greg Harris (2) | Second | 1½ out |
| Sunday, May 19 |
| » Defeated Rangers (10-25), 5-1 | Comiskey Park I (13-6) | 19-14 | |
| » W: Gene Nelson (3-1) L: Charlie Hough (3-3) | Second | 1½ out |
| » Major-league debuts: Oddibe McDowell (Rangers) |
| Monday, May 20 |
| » Lost to Blue Jays (22-14), 6-1 | Exhibition Stadium (0-1) | 19-15 | |
| » W: Jimmy Key (3-2) L: Tom Seaver (4-2) | Third | 1½ out |
| Tuesday, May 21 |
| » Lost to Blue Jays (23-14), 4-3 | Exhibition Stadium (0-2) | 19-16 | Lost 2 |
| » W: Gary Lavelle (1-0) L: Bob James (1-1) | Third | 2½ out |
| Wednesday, May 22 |
| » Lost to Blue Jays (24-14), 10-0 | Exhibition Stadium (0-3) | 19-17 | Lost 3 |
| » W: Dave Stieb (4-3) L: Richard Dotson (2-2) | Third | 2½ out |
| Friday, May 24 |
| » Lost to Royals (21-18), 8-4 | Royals Stadium (0-1) | 19-18 | Lost 4 |
| » W: Danny Jackson (3-2) L: Britt Burns (5-4) S: Dan Quisenberry (7) | Fourth | 2½ out |
| Saturday, May 25 |
| » Lost to Royals (22-18), 3-0 | Royals Stadium (0-2) | 19-19 | Lost 5 |
| » W: Charlie Leibrandt (5-2) L: Tom Seaver (4-3) | Fourth | 3½ out |
| Sunday, May 26 |
| » Lost to Royals (23-18), 3-2 | Royals Stadium (0-3) | 19-20 | Lost 6 |
| » W: Bud Black (5-3) L: Bob James (1-2) S: Dan Quisenberry (8) | Fourth | 4½ out |
| Tuesday, May 28 |
| » Lost to Blue Jays (29-14), 6-1 | Comiskey Park I (13-7) | 19-21 | Lost 7 |
| » W: Dave Stieb (5-3) L: Richard Dotson (2-3) | Fourth | 4½ out |
| Wednesday, May 29 |
| » Defeated Blue Jays (29-15), 8-5 | Comiskey Park I (14-7) | 20-21 | |
| » W: Britt Burns (6-4) L: Jim Clancy (1-2) S: Bob James (8) | Third | 3½ out |
| Thursday, May 30 |
| » Defeated Royals (25-20), 4-3 | Comiskey Park I (15-7) | 21-21 | Won 2 |
| » W: Tom Seaver (5-3) L: Charlie Leibrandt (5-3) S: Bob James (9) | Second | 2½ out |
| Friday, May 31 |
| » Defeated Royals (25-21), 8-3 | Comiskey Park I (16-7) | 22-21 | Won 3 |
| » W: Floyd Bannister (3-4) L: Bud Black (5-4) S: Gene Nelson (1) | Third | 2½ out |
| Saturday, June 1 |
| » Defeated Royals (25-22), 8-7 | Comiskey Park I (17-7) | 23-21 | Won 4 |
| » W: Bob James (2-2) L: Mike Jones (0-2) | Third | 2½ out |
| Sunday, June 2 |
| » Defeated Royals (25-23), 4-1 | Comiskey Park I (18-7) | 24-21 | Won 5 |
| » W: Richard Dotson (3-3) L: Mark Gubicza (1-4) S: Bob James (10) | Second | 1½ out |
| Monday, June 3 |
| » Lost to Rangers (18-31), 7-3 | Arlington Stadium (0-1) | 24-22 | |
| » W: Greg Harris (1-1) L: Britt Burns (6-5) | Second | 1½ out |
| » Major-league debuts: John Cangelosi (White Sox) |
| Tuesday, June 4 |
| » Lost to Rangers (19-31), 7-3 | Arlington Stadium (0-2) | 24-23 | Lost 2 |
| » W: Charlie Hough (5-4) L: Tom Seaver (5-4) | Third | 2½ out |
| Thursday, June 6 |
| » Defeated Rangers (19-32), 4-3 | Arlington Stadium (1-2) | 25-23 | |
| » W: Floyd Bannister (4-4) L: Mike Mason (4-5) S: Bob James (11) | Second | 1½ out |
| Friday, June 7 |
| » Lost to Twins (23-28), 6-3 | Hubert H. Humphrey Metrodome (0-1) | 25-24 | |
| » W: Pete Filson (3-2) L: Richard Dotson (3-4) | Third | 1½ out |
| Saturday, June 8 |
| » Defeated Twins (23-29), 3-1 | Hubert H. Humphrey Metrodome (1-1) | 26-24 | |
| » W: Britt Burns (7-5) L: John Butcher (4-5) S: Bob James (12) | Third | 1 out |
| Sunday, June 9 |
| » Defeated Twins (23-30), 5-1 | Hubert H. Humphrey Metrodome (2-1) | 27-24 | Won 2 |
| » W: Tom Seaver (6-4) L: Ken Schrom (4-5) | Second | 1½ out |
| Monday, June 10 |
| » Defeated Mariners (25-31), 9-4 | Kingdome (1-0) | 28-24 | Won 3 |
| » W: Floyd Bannister (5-4) L: Matt Young (4-8) S: Bob James (13) | Second | 1½ out |
| Tuesday, June 11 |
| » Defeated Mariners (25-32), 7-1 | Kingdome (2-0) | 29-24 | Won 4 |
| » W: Tim Lollar (2-2) L: Bill Swift (1-1) | First | -- |
| Wednesday, June 12 |
| » Defeated Mariners (25-33), 6-3 | Kingdome (3-0) | 30-24 | Won 5 |
| » W: Bruce Tanner (1-0) L: Brian Snyder (0-1) S: Bob James (14) | First | -- |
| » Major-league debuts: Bruce Tanner (White Sox) |
| Thursday, June 13 |
| » Lost to Angels (32-26), 2-1 | Anaheim Stadium (0-1) | 30-25 | |
| » W: Donnie Moore (4-3) L: Gene Nelson (3-2) | Second | 1½ out |
| Friday, June 14 |
| » Defeated Angels (32-27), 4-2 | Anaheim Stadium (1-1) | 31-25 | |
| » W: Tom Seaver (7-4) L: Ron Romanick (7-3) S: Bob James (15) | First | -- |
| Saturday, June 15 |
| » Defeated Angels (32-28), 3-2 | Anaheim Stadium (2-1) | 32-25 | Won 2 |
| » W: Dan Spillner (1-1) L: Kirk McCaskill (1-5) S: Bob James (16) | First | -- |
| Sunday, June 16 |
| » Lost to Angels (33-28), 3-1 | Anaheim Stadium (2-2) | 32-26 | |
| » W: Urbano Lugo (1-1) L: Tim Lollar (2-3) S: Donnie Moore (14) | First | -- |
| Tuesday, June 18 |
| » Defeated Athletics (31-31), 4-3 | Comiskey Park I (19-7) | 33-26 | |
| » W: Gene Nelson (4-2) L: Keith Atherton (2-3) | First | -- |
| Wednesday, June 19 |
| » Defeated Athletics (31-32), 8-7 | Comiskey Park I (20-7) | 34-26 | Won 2 |
| » W: Bob James (3-2) L: Rick Langford (0-1) | First | -- |
| Thursday, June 20 |
| » Lost to Athletics (32-32), 12-1 | Comiskey Park I (20-8) | 34-27 | |
| » W: Tim Birtsas (4-1) L: Tom Seaver (7-5) | First | -- |
| Friday, June 21 |
| » Lost to Angels (36-29), 5-2 | Comiskey Park I (20-9) | 34-28 | Lost 2 |
| » W: Kirk McCaskill (2-5) L: Floyd Bannister (5-5) S: Donnie Moore (15) | Second | 1½ out |
| Saturday, June 22 |
| » Lost to Angels (37-29), 6-3 | Comiskey Park I (20-10) | 34-29 | Lost 3 |
| » W: Urbano Lugo (2-1) L: Tim Lollar (2-4) S: Stew Cliburn (2) | Second | 1½ out |
| Sunday, June 23 |
| » Lost to Angels (38-29), 11-1 | Comiskey Park I (20-11) | 34-30 | Lost 4 |
| » W: Mike Witt (6-6) L: Bruce Tanner (1-1) | Second | 2½ out |
| Monday, June 24 |
| » Defeated Athletics (35-33), 7-1 | Oakland-Alameda County Stadium (1-0) | 35-30 | |
| » W: Dan Spillner (2-1) L: Tim Birtsas (4-2) S: Gene Nelson (2) | Second | 1½ out |
| Tuesday, June 25 |
| » Lost to Athletics (36-33), 5-4 | Oakland-Alameda County Stadium (1-1) | 35-31 | |
| » W: Keith Atherton (3-3) L: Gene Nelson (4-3) | Second | 2½ out |
| Wednesday, June 26 |
| » Lost to Athletics (37-33), 10-0 | Oakland-Alameda County Stadium (1-2) | 35-32 | Lost 2 |
| » W: Don Sutton (7-5) L: Floyd Bannister (5-6) | Third | 3½ out |
| Friday, June 28 |
| » Lost to Twins (31-38), 5-4 | Comiskey Park I (20-12) | 35-33 | Lost 3 |
| » W: Frank Viola (9-6) L: Bruce Tanner (1-2) S: Ron Davis (8) | Third | 3½ out |
| Saturday, June 29 |
| » Lost to Twins (32-38), 1-0 | Comiskey Park I (20-13) | 35-34 | Lost 4 |
| » W: Mike Smithson (6-7) L: Britt Burns (7-6) S: Frank Eufemia (1) | Fourth | 4½ out |
| Sunday, June 30 |
| » Lost to Twins (33-38), 4-3 | Comiskey Park I (20-14) | 35-35 | Lost 5 |
| » W: John Butcher (5-7) L: Tom Seaver (7-6) S: Ron Davis (9) | Fourth | 4½ out |
| Monday, July 1 |
| » Lost to Mariners (37-37), 3-1 | Comiskey Park I (20-15) | 35-36 | Lost 6 |
| » W: Frank Wills (4-1) L: Floyd Bannister (5-7) S: Edwin Nunez (12) | Fifth | 4½ out |
| Tuesday, July 2 |
| » Defeated Mariners (37-38), 12-4 | Comiskey Park I (21-15) | 36-36 | |
| » W: Tim Lollar (3-4) L: Brian Snyder (0-2) S: Bob James (17) | Fourth | 4½ out |
| Wednesday, July 3 |
| » Lost to Mariners (38-38), 5-1 | Comiskey Park I (21-16) | 36-37 | |
| » W: Bill Swift (3-1) L: Dan Spillner (2-2) | Fifth | 5½ out |
| Thursday, July 4 |
| » Defeated Indians (24-52), 5-0 | Cleveland Stadium (3-0) | 37-37 | |
| » W: Britt Burns (8-6) L: Bert Blyleven (7-8) | Fifth | 5½ out |
| Friday, July 5 |
| » Defeated Indians (24-53), 8-3 | Cleveland Stadium (4-0) | 38-37 | Won 2 |
| » W: Tom Seaver (8-6) L: Jerry Reed (0-1) | Fourth | 5½ out |
| Saturday, July 6 |
| » Defeated Indians (24-54), 6-4 | Cleveland Stadium (5-0) | 39-37 | Won 3 |
| » W: Bob James (4-2) L: Rich Thompson (2-3) | Fourth | 4½ out |
| Sunday, July 7 |
| » Lost to Indians (25-54), 10-3 | Cleveland Stadium (5-1) | 39-38 | |
| » W: Tom Waddell (3-5) L: Tim Lollar (3-5) | Fifth | 5½ out |
| Monday, July 8 |
| » Defeated Tigers (45-34), 9-4 | Tiger Stadium (2-2) | 40-38 | |
| » W: Gene Nelson (5-3) L: Dan Petry (10-7) | Third | 5½ out |
| Tuesday, July 9 |
| » Lost to Tigers (46-34), 6-5 | Tiger Stadium (2-3) | 40-39 | |
| » W: Willie Hernandez (5-4) L: Bob James (4-3) | Fourth | 6½ out |
| Wednesday, July 10 |
| » Lost to Tigers (47-34), 1-0 | Tiger Stadium (2-4) | 40-40 | Lost 2 |
| » W: Jack Morris (10-6) L: Tom Seaver (8-7) | Third | 7½ out |
| Thursday, July 11 |
| » Lost to Orioles (43-39), 7-6 | Memorial Stadium (0-3) | 40-41 | Lost 3 |
| » W: Sammy Stewart (3-4) L: Mike Stanton (1-3) | Fourth | 7½ out |
| Friday, July 12 |
| » Lost to Orioles (44-39), 10-3 | Memorial Stadium (0-4) | 40-42 | Lost 4 |
| » W: Ken Dixon (5-3) L: Gene Nelson (5-4) S: Don Aase (3) | Fourth | 8½ out |
| Saturday, July 13 |
| » Defeated Orioles (44-40), 10-8 | Memorial Stadium (1-4) | 41-42 | |
| » W: Britt Burns (9-6) L: Dennis Martinez (7-6) | Fourth | 8½ out |
| Sunday, July 14 |
| » Defeated Orioles (44-41), 5-3 | Memorial Stadium (2-4) | 42-42 | Won 2 |
| » W: Tom Seaver (9-7) L: Mike Boddicker (9-9) S: Dan Spillner (1) | Fourth | 8½ out |
| Thursday, July 18 |
| » Defeated Indians (28-59), 10-0 | Comiskey Park I (22-16) | 43-42 | Won 3 |
| » W: Britt Burns (10-6) L: Vern Ruhle (2-5) | Fourth | 7½ out |
| Friday, July 19 |
| » Defeated Indians (28-60), 1-0 | Comiskey Park I (23-16) | 44-42 | Won 4 |
| » W: Tom Seaver (10-7) L: Bert Blyleven (8-10) | Third | 7½ out |
| Saturday, July 20 |
| » Defeated Indians (28-61), 8-6 | Comiskey Park I (24-16) | 45-42 | Won 5 |
| » W: Juan Agosto (1-1) L: Bryan Clark (1-2) | Fourth | 7½ out |
| Sunday, July 21 |
| » Lost to Indians (29-61), 4-3 | Comiskey Park I (24-17) | 45-43 | |
| » W: Rich Thompson (3-3) L: Dan Spillner (2-3) | Fourth | 7½ out |
| » Major-league debuts: Bill Long (White Sox) |
| Monday, July 22 |
| » Defeated Tigers (49-41), 9-4 | Comiskey Park I (25-17) | 46-43 | |
| » W: Gene Nelson (6-4) L: Randy O'Neal (5-3) S: Jerry Don Gleaton (1) | Third | 6½ out |
| Tuesday, July 23 |
| » Defeated Tigers (49-42), 5-3 | Comiskey Park I (26-17) | 47-43 | Won 2 |
| » W: Britt Burns (11-6) L: Frank Tanana (4-10) | Third | 6½ out |
| Wednesday, July 24 |
| » Lost to Tigers (50-42), 5-4 | Comiskey Park I (26-18) | 47-44 | |
| » W: Dan Petry (11-9) L: Tom Seaver (10-8) | Third | 7½ out |
| Thursday, July 25 |
| » Lost to Orioles (48-45), 5-1 | Comiskey Park I (26-19) | 47-45 | Lost 2 |
| » W: Mike Flanagan (1-1) L: Floyd Bannister (5-8) | Fourth | 7½ out |
| Friday, July 26 |
| » Defeated Orioles (48-46), 9-8 | Comiskey Park I (27-19) | 48-45 | |
| » W: Juan Agosto (2-1) L: Don Aase (5-5) | Fourth | 6½ out |
| Saturday, July 27 |
| » Lost to Orioles (49-46), 9-1 | Comiskey Park I (27-20) | 48-46 | |
| » W: Storm Davis (5-6) L: Gene Nelson (6-5) | Fourth | 6½ out |
| Sunday, July 28 |
| » Lost to Orioles (50-46), 6-1 | Comiskey Park I (27-21) | 48-47 | Lost 2 |
| » W: Scott McGregor (9-8) L: Britt Burns (11-7) | Fourth | 6½ out |
| Tuesday, July 30 |
| » Defeated Red Sox (52-47), 7-5 | Fenway Park (3-1) | 49-47 | |
| » W: Tom Seaver (11-8) L: Oil Can Boyd (11-9) S: Juan Agosto (1) | Fourth | 5½ out |
| Wednesday, July 31 |
| » Tied Red Sox, 1-1 | Fenway Park (3-1) | 49-47 | |
| » Starters: Floyd Bannister vs Bob Ojeda | Fourth | 6 out |
| Thursday, August 1 |
| » Defeated Red Sox (52-48), 7-2 | Fenway Park (4-1) | 50-47 | Won 2 |
| » W: Gene Nelson (7-5) L: Al Nipper (7-7) | Fourth | 5½ out |
| » Lost to Red Sox (53-48), 4-3 | Fenway Park (4-2) | 50-48 | |
| » W: Steve Crawford (5-2) L: Juan Agosto (2-2) | Fourth | 5½ out |
| Friday, August 2 |
| » Defeated Yankees (55-46), 6-5 | Yankee Stadium (1-2) | 51-48 | |
| » W: Juan Agosto (3-2) L: Rich Bordi (2-4) | Fourth | 5½ out |
| Saturday, August 3 |
| » Lost to Yankees (56-46), 8-4 | Yankee Stadium (1-3) | 51-49 | |
| » W: Ed Whitson (7-7) L: Bill Long (0-1) S: Dave Righetti (19) | Fourth | 6½ out |
| Sunday, August 4 |
| » Defeated Yankees (56-47), 4-1 | Yankee Stadium (2-3) | 52-49 | |
| » W: Tom Seaver (12-8) L: Joe Cowley (9-5) | Fourth | 6½ out |
| Monday, August 5 |
| » Lost to Yankees (57-47), 7-3 | Yankee Stadium (2-4) | 52-50 | |
| » W: Ron Guidry (14-4) L: Floyd Bannister (5-9) | Fourth | 7½ out |
| Thursday, August 8 |
| » Defeated Red Sox (55-50), 7-6 | Comiskey Park I (28-21) | 53-50 | |
| » W: Dave Wehrmeister (1-0) L: Bruce Kison (3-3) S: Bob James (18) | Fourth | 7 out |
| » Lost to Red Sox (56-50), 6-1 | Comiskey Park I (28-22) | 53-51 | |
| » W: Tim Lollar (5-6) L: Gene Nelson (7-6) S: Steve Crawford (5) | Fourth | 7 out |
| Friday, August 9 |
| » Lost to Brewers (48-57), 8-7 | Comiskey Park I (28-23) | 53-52 | Lost 2 |
| » W: Rick Waits (2-2) L: Bob James (4-4) S: Rollie Fingers (13) | Fourth | 7 out |
| Saturday, August 10 |
| » Lost to Brewers (49-57), 5-2 | Comiskey Park I (28-24) | 53-53 | Lost 3 |
| » W: Teddy Higuera (9-6) L: Juan Agosto (3-3) S: Bob Gibson (9) | Fourth | 8 out |
| Sunday, August 11 |
| » Defeated Brewers (49-58), 4-1 | Comiskey Park I (29-24) | 54-53 | |
| » W: Joel Davis (1-0) L: Ray Burris (6-9) S: Bob James (19) | Fourth | 8 out |
| » Major-league debuts: Joel Davis (White Sox) |
| Monday, August 12 |
| » Lost to Yankees (63-47), 10-4 | Comiskey Park I (29-25) | 54-54 | |
| » W: Phil Niekro (11-9) L: Gene Nelson (7-7) | Fourth | 8½ out |
| Tuesday, August 13 |
| » Defeated Yankees (63-48), 4-3 | Comiskey Park I (30-25) | 55-54 | |
| » W: Britt Burns (12-7) L: Brian Fisher (3-3) S: Bob James (20) | Fourth | 7½ out |
| Wednesday, August 14 |
| » Lost to Yankees (64-48), 10-7 | Comiskey Park I (30-26) | 55-55 | |
| » W: Brian Fisher (4-3) L: Bob James (4-5) S: Dave Righetti (22) | Fourth | 8 out |
| Thursday, August 15 |
| » Lost to Brewers (51-60), 7-5 | County Stadium (1-2) | 55-56 | Lost 2 |
| » W: Teddy Higuera (10-6) L: Floyd Bannister (5-10) S: Rollie Fingers (15) | Fourth | 8½ out |
| Friday, August 16 |
| » Lost to Brewers (52-60), 3-2 | County Stadium (1-3) | 55-57 | Lost 3 |
| » W: Ray Burris (7-9) L: Dave Wehrmeister (1-1) | Fourth | 9½ out |
| Saturday, August 17 |
| » Defeated Brewers (52-61), 12-7 | County Stadium (2-3) | 56-57 | |
| » W: Dan Spillner (3-3) L: Jaime Cocanower (3-2) | Fourth | 9½ out |
| Sunday, August 18 |
| » Defeated Brewers (52-62), 8-4 | County Stadium (3-3) | 57-57 | Won 2 |
| » W: Britt Burns (13-7) L: Pete Vuckovich (6-9) S: Bob James (21) | Fourth | 8½ out |
| Tuesday, August 20 |
| » Defeated Royals (64-52), 2-1 | Comiskey Park I (31-26) | 58-57 | Won 3 |
| » W: Bob James (5-5) L: Dan Quisenberry (6-7) | Fourth | 8 out |
| Wednesday, August 21 |
| » Lost to Royals (65-52), 2-1 | Comiskey Park I (31-27) | 58-58 | |
| » W: Charlie Leibrandt (12-6) L: Floyd Bannister (5-11) S: Dan Quisenberry (29) | Fourth | 8 out |
| Thursday, August 22 |
| » Lost to Royals (66-52), 7-3 | Comiskey Park I (31-28) | 58-59 | Lost 2 |
| » W: Danny Jackson (12-7) L: Joel Davis (1-1) S: Dan Quisenberry (30) | Fourth | 9 out |
| Friday, August 23 |
| » Lost to Blue Jays (75-46), 6-3 | Comiskey Park I (31-29) | 58-60 | Lost 3 |
| » W: Tom Filer (7-0) L: Britt Burns (13-8) S: Tom Henke (5) | Fourth | 10½ out |
| » Lost to Blue Jays (76-46), 10-3 | Comiskey Park I (31-30) | 58-61 | Lost 4 |
| » W: Jim Acker (6-2) L: Gene Nelson (7-8) | Fourth | 10½ out |
| Saturday, August 24 |
| » Lost to Blue Jays (77-46), 6-3 | Comiskey Park I (31-31) | 58-62 | Lost 5 |
| » W: Dave Stieb (12-9) L: Tom Seaver (12-9) S: Tom Henke (6) | Fourth | 10½ out |
| Sunday, August 25 |
| » Defeated Blue Jays (77-47), 5-3 | Comiskey Park I (32-31) | 59-62 | |
| » W: Floyd Bannister (6-11) L: Jimmy Key (10-6) S: Bob James (22) | Fourth | 10½ out |
| » Major-league debuts: Steve Davis (Blue Jays) |
| Monday, August 26 |
| » Defeated Red Sox (58-64), 7-6 | Comiskey Park I (33-31) | 60-62 | Won 2 |
| » W: Bob James (6-5) L: Bob Stanley (6-6) | Fourth | 9½ out |
| Tuesday, August 27 |
| » Defeated Rangers (46-78), 7-4 | Comiskey Park I (34-31) | 61-62 | Won 3 |
| » W: Britt Burns (14-8) L: Dickie Noles (4-8) S: Dave Wehrmeister (1) | Fourth | 9½ out |
| Wednesday, August 28 |
| » Defeated Rangers (46-79), 5-1 | Comiskey Park I (35-31) | 62-62 | Won 4 |
| » W: Gene Nelson (8-8) L: Dave Stewart (0-5) | Fourth | 9 out |
| Thursday, August 29 |
| » Defeated Rangers (46-80), 6-5 | Comiskey Park I (36-31) | 63-62 | Won 5 |
| » W: Dan Spillner (4-3) L: Dave Schmidt (5-4) | Fourth | 8 out |
| Friday, August 30 |
| » Lost to Blue Jays (80-48), 5-3 | Exhibition Stadium (0-4) | 63-63 | |
| » W: Jimmy Key (11-6) L: Floyd Bannister (6-12) S: Tom Henke (8) | Fourth | 9 out |
| Saturday, August 31 |
| » Lost to Blue Jays (81-48), 6-2 | Exhibition Stadium (0-5) | 63-64 | Lost 2 |
| » W: Gary Lavelle (4-6) L: Joel Davis (1-2) | Fourth | 9 out |
| Sunday, September 1 |
| » Defeated Blue Jays (81-49), 4-1 | Exhibition Stadium (1-5) | 64-64 | |
| » W: Britt Burns (15-8) L: Steve Davis (1-1) | Fourth | 8 out |
| » Major-league debuts: John Cerutti (Blue Jays) |
| Monday, September 2 |
| » Lost to Royals (70-58), 3-2 | Royals Stadium (0-4) | 64-65 | |
| » W: Mark Gubicza (11-7) L: Gene Nelson (8-9) S: Dan Quisenberry (31) | Fourth | 9 out |
| Tuesday, September 3 |
| » Lost to Royals (71-58), 3-2 | Royals Stadium (0-5) | 64-66 | Lost 2 |
| » W: Bret Saberhagen (17-5) L: Tom Seaver (12-10) | Fourth | 9 out |
| Wednesday, September 4 |
| » Lost to Royals (72-58), 6-5 | Royals Stadium (0-6) | 64-67 | Lost 3 |
| » W: Mike Jones (3-2) L: Bob James (6-6) | Fourth | 10 out |
| Thursday, September 5 |
| » Defeated Rangers (49-83), 11-4 | Arlington Stadium (2-2) | 65-67 | |
| » W: Joel Davis (2-2) L: Jeff Russell (1-5) | Fourth | 9½ out |
| Friday, September 6 |
| » Defeated Rangers (49-84), 12-1 | Arlington Stadium (3-2) | 66-67 | Won 2 |
| » W: Britt Burns (16-8) L: Mike Mason (6-13) | Fourth | 9 out |
| Saturday, September 7 |
| » Defeated Rangers (49-85), 3-2 | Arlington Stadium (4-2) | 67-67 | Won 3 |
| » W: Juan Agosto (4-3) L: Dwayne Henry (1-1) S: Bob James (23) | Third | 9 out |
| Sunday, September 8 |
| » Defeated Rangers (49-86), 7-6 | Arlington Stadium (5-2) | 68-67 | Won 4 |
| » W: Tom Seaver (13-10) L: Charlie Hough (14-14) S: Bob James (24) | Third | 9 out |
| Monday, September 9 |
| » Lost to Twins (62-74), 5-0 | Comiskey Park I (36-32) | 68-68 | |
| » W: John Butcher (10-12) L: Floyd Bannister (6-13) | Third | 9 out |
| Tuesday, September 10 |
| » Defeated Twins (62-75), 7-2 | Comiskey Park I (37-32) | 69-68 | |
| » W: Joel Davis (3-2) L: Bert Blyleven (13-15) S: Bob James (25) | Third | 9 out |
| Wednesday, September 11 |
| » Defeated Twins (62-76), 5-0 | Comiskey Park I (38-32) | 70-68 | Won 2 |
| » W: Britt Burns (17-8) L: Frank Viola (13-14) | Third | 9 out |
| Thursday, September 12 |
| » Defeated Twins (62-77), 4-2 | Comiskey Park I (39-32) | 71-68 | Won 3 |
| » W: Gene Nelson (9-9) L: Mike Smithson (14-12) S: Bob James (26) | Third | 8½ out |
| Friday, September 13 |
| » Defeated Mariners (65-75), 6-1 | Kingdome (4-0) | 72-68 | Won 4 |
| » W: Jerry Don Gleaton (1-0) L: Matt Young (11-15) | Third | 8½ out |
| Saturday, September 14 |
| » Lost to Mariners (66-75), 6-5 | Kingdome (4-1) | 72-69 | |
| » W: Bill Swift (5-9) L: Floyd Bannister (6-14) S: Edwin Nunez (15) | Third | 9½ out |
| Sunday, September 15 |
| » Defeated Mariners (66-76), 6-3 | Kingdome (5-1) | 73-69 | |
| » W: Dave Wehrmeister (2-1) L: Mark Langston (7-13) S: Bob James (27) | Third | 9 out |
| Tuesday, September 17 |
| » Defeated Angels (80-64), 5-2 | Comiskey Park I (40-32) | 74-69 | Won 2 |
| » W: Britt Burns (18-8) L: Mike Witt (13-8) S: Bob James (28) | Third | 7½ out |
| Wednesday, September 18 |
| » Lost to Angels (81-64), 9-3 | Comiskey Park I (40-33) | 74-70 | |
| » W: Don Sutton (15-8) L: Gene Nelson (9-10) | Third | 7½ out |
| » Major-league debuts: Ed Correa (White Sox) |
| Thursday, September 19 |
| » Lost to Angels (82-64), 8-0 | Comiskey Park I (40-34) | 74-71 | Lost 2 |
| » W: John Candelaria (8-5) |