| Friday, March 1 |
| Former Twin George Banks dies in Spartanburg, SC at the age of 47. |
| Monday, April 8 |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Tuesday, April 9 |
| » Defeated Angels (0-1), 6-2 | Anaheim Stadium (1-0) | 1-0 | |
| » W: Frank Viola (1-0) L: Mike Witt (0-1) S: Ron Davis (1) | First | -- |
| » Major-league debuts: Pat Clements (Angels) |
| Wednesday, April 10 |
| » Defeated Angels (0-2), 6-3 | Anaheim Stadium (2-0) | 2-0 | Won 2 |
| » W: Mike Smithson (1-0) L: Donnie Moore (0-1) S: Ron Davis (2) | First | -- |
| Thursday, April 11 |
| » Lost to Angels (1-2), 4-3 | Anaheim Stadium (2-1) | 2-1 | |
| » W: Donnie Moore (1-1) L: Rick Lysander (0-1) | Second | 1 out |
| Friday, April 12 |
| » Lost to Mariners (4-0), 2-1 | Kingdome (0-1) | 2-2 | Lost 2 |
| » W: Matt Young (1-0) L: Ken Schrom (0-1) S: Edwin Nunez (3) | Third | 2 out |
| Saturday, April 13 |
| » Lost to Mariners (5-0), 8-7 | Kingdome (0-2) | 2-3 | Lost 3 |
| » W: Mike Stanton (1-0) L: Ron Davis (0-1) | Second | 3 out |
| » Major-league debuts: Rich Yett (Twins) |
| Sunday, April 14 |
| » Lost to Mariners (6-0), 5-1 | Kingdome (0-3) | 2-4 | Lost 4 |
| » W: Mike Moore (2-0) L: Frank Viola (1-1) | Third | 4 out |
| Monday, April 15 |
| » Lost to Angels (3-4), 5-0 | Hubert H. Humphrey Metrodome (0-1) | 2-5 | Lost 5 |
| » W: Geoff Zahn (1-0) L: Mike Smithson (1-1) | Fourth | 4 out |
| Wednesday, April 17 |
| » Lost to Angels (4-4), 4-3 | Hubert H. Humphrey Metrodome (0-2) | 2-6 | Lost 6 |
| » W: Jim Slaton (1-0) L: John Butcher (0-1) S: Donnie Moore (1) | Sixth | 3½ out |
| Thursday, April 18 |
| » Lost to Angels (5-4), 9-8 | Hubert H. Humphrey Metrodome (0-3) | 2-7 | Lost 7 |
| » W: Doug Corbett (1-0) L: Ken Schrom (0-2) S: Donnie Moore (2) | Fifth | 4 out |
| Friday, April 19 |
| » Lost to Athletics (6-4), 4-2 | Oakland-Alameda County Stadium (0-1) | 2-8 | Lost 8 |
| » W: Chris Codiroli (2-1) L: Frank Viola (1-2) S: Jay Howell (4) | Fifth | 4 out |
| Saturday, April 20 |
| » Lost to Athletics (7-4), 6-2 | Oakland-Alameda County Stadium (0-2) | 2-9 | Lost 9 |
| » W: Bill Krueger (2-1) L: Mike Smithson (1-2) | Sixth | 5 out |
| Sunday, April 21 |
| » Defeated Athletics (7-5), 2-0 | Oakland-Alameda County Stadium (1-2) | 3-9 | |
| » W: John Butcher (1-1) L: Curt Young (0-2) | Fifth | 4 out |
| Monday, April 22 |
| » Defeated Mariners (7-6), 9-5 | Hubert H. Humphrey Metrodome (1-3) | 4-9 | Won 2 |
| » W: Ken Schrom (1-2) L: Matt Young (1-2) S: Rick Lysander (1) | Sixth | 4 out |
| Tuesday, April 23 |
| » Defeated Mariners (7-7), 4-2 | Hubert H. Humphrey Metrodome (2-3) | 5-9 | Won 3 |
| » W: Frank Viola (2-2) L: Salome Barojas (0-1) | Sixth | 3 out |
| Wednesday, April 24 |
| » Defeated Mariners (7-8), 10-0 | Hubert H. Humphrey Metrodome (3-3) | 6-9 | Won 4 |
| » W: Mike Smithson (2-2) L: Mike Moore (2-2) | Sixth | 3 out |
| Thursday, April 25 |
| » Defeated Athletics (9-7), 5-4 | Hubert H. Humphrey Metrodome (4-3) | 7-9 | Won 5 |
| » W: John Butcher (2-1) L: Keith Atherton (1-1) | Fourth | 2 out |
| Friday, April 26 |
| » Defeated Athletics (9-8), 8-7 | Hubert H. Humphrey Metrodome (5-3) | 8-9 | Won 6 |
| » W: Ron Davis (1-1) L: Keith Atherton (1-2) | Fourth | 2 out |
| Saturday, April 27 |
| » Defeated Athletics (9-9), 8-6 | Hubert H. Humphrey Metrodome (6-3) | 9-9 | Won 7 |
| » W: Frank Viola (3-2) L: Don Sutton (2-2) S: Ron Davis (3) | Fourth | 2 out |
| Sunday, April 28 |
| » Defeated Athletics (9-10), 10-1 | Hubert H. Humphrey Metrodome (7-3) | 10-9 | Won 8 |
| » W: Mike Smithson (3-2) L: Mike Warren (1-2) | Fourth | 2 out |
| Tuesday, April 30 |
| » Defeated Tigers (11-7), 11-2 | Tiger Stadium (1-0) | 11-9 | Won 9 |
| » W: John Butcher (3-1) L: Milt Wilcox (0-1) | Third | 2½ out |
| Wednesday, May 1 |
| » Defeated Tigers (11-8), 7-3 | Tiger Stadium (2-0) | 12-9 | Won 10 |
| » W: Frank Viola (4-2) L: Jack Morris (3-3) S: Rick Lysander (2) | Second | 1½ out |
| Friday, May 3 |
| » Lost to Orioles (14-7), 8-7 | Hubert H. Humphrey Metrodome (7-4) | 12-10 | |
| » W: Don Aase (3-0) L: Curt Wardle (0-1) | Second | 2 out |
| Saturday, May 4 |
| » Defeated Orioles (14-8), 8-6 | Hubert H. Humphrey Metrodome (8-4) | 13-10 | |
| » W: Ken Schrom (2-2) L: Dennis Martinez (2-2) S: Ron Davis (4) | Second | 2 out |
| Sunday, May 5 |
| » Lost to Orioles (15-8), 10-5 | Hubert H. Humphrey Metrodome (8-5) | 13-11 | |
| » W: Mike Boddicker (4-1) L: John Butcher (3-2) | Second | 3 out |
| Tuesday, May 7 |
| » Defeated Yankees (10-13), 8-6 | Hubert H. Humphrey Metrodome (9-5) | 14-11 | |
| » W: Frank Viola (5-2) L: Ed Whitson (1-4) | Second | 2 out |
| » Major-league debuts: Brian Fisher (Yankees) |
| Wednesday, May 8 |
| » Defeated Yankees (10-14), 8-6 | Hubert H. Humphrey Metrodome (10-5) | 15-11 | Won 2 |
| » W: Mike Smithson (4-2) L: Joe Cowley (0-2) S: Pete Filson (1) | Second | 1 out |
| Friday, May 10 |
| » Lost to Orioles (17-9), 6-5 | Memorial Stadium (0-1) | 15-12 | |
| » W: Don Aase (4-0) L: Ron Davis (1-2) | Second | 2 out |
| Saturday, May 11 |
| » Lost to Orioles (18-9), 4-2 | Memorial Stadium (0-2) | 15-13 | Lost 2 |
| » W: Mike Boddicker (5-1) L: Ron Davis (1-3) | Second | 3 out |
| Sunday, May 12 |
| » Defeated Orioles (18-10), 7-3 | Memorial Stadium (1-2) | 16-13 | |
| » W: Frank Viola (6-2) L: Ken Dixon (3-1) | Second | 2 out |
| Monday, May 13 |
| » Lost to Yankees (13-15), 9-8 | Yankee Stadium (0-1) | 16-14 | |
| » W: Joe Cowley (1-2) L: Ron Davis (1-4) | Third | 2½ out |
| Tuesday, May 14 |
| » Lost to Yankees (14-15), 10-7 | Yankee Stadium (0-2) | 16-15 | Lost 2 |
| » W: Brian Fisher (1-0) L: Curt Wardle (0-2) S: Dave Righetti (9) | Third | 2½ out |
| Wednesday, May 15 |
| » Defeated Tigers (18-12), 5-4 | Hubert H. Humphrey Metrodome (11-5) | 17-15 | |
| » W: Curt Wardle (1-2) L: Aurelio Lopez (0-2) | Third | 2½ out |
| Thursday, May 16 |
| » Defeated Tigers (18-13), 7-5 | Hubert H. Humphrey Metrodome (12-5) | 18-15 | Won 2 |
| » W: Ken Schrom (3-2) L: Juan Berenguer (1-3) S: Ron Davis (5) | Third | 2 out |
| Friday, May 17 |
| » Defeated Blue Jays (20-13), 7-6 | Hubert H. Humphrey Metrodome (13-5) | 19-15 | Won 3 |
| » W: Pete Filson (1-0) L: Luis Leal (2-3) | Third | 1 out |
| Saturday, May 18 |
| » Lost to Blue Jays (21-13), 3-1 | Hubert H. Humphrey Metrodome (13-6) | 19-16 | |
| » W: Jim Clancy (1-1) L: Mike Smithson (4-3) S: Jim Acker (5) | Third | 1 out |
| Sunday, May 19 |
| » Defeated Blue Jays (21-14), 8-2 | Hubert H. Humphrey Metrodome (14-6) | 20-16 | |
| » W: Pete Filson (2-0) L: Doyle Alexander (5-2) | Third | 1 out |
| Monday, May 20 |
| » Defeated Red Sox (16-20), 5-2 | Hubert H. Humphrey Metrodome (15-6) | 21-16 | Won 2 |
| » W: John Butcher (4-2) L: Al Nipper (1-3) S: Curt Wardle (1) | Second | 1 out |
| Tuesday, May 21 |
| » Lost to Red Sox (17-20), 9-1 | Hubert H. Humphrey Metrodome (15-7) | 21-17 | |
| » W: Bruce Kison (1-0) L: Ken Schrom (3-3) | Second | 2 out |
| Wednesday, May 22 |
| » Lost to Red Sox (18-20), 4-3 | Hubert H. Humphrey Metrodome (15-8) | 21-18 | Lost 2 |
| » W: Roger Clemens (5-4) L: Frank Viola (6-3) S: Bob Stanley (6) | Second | 2 out |
| Friday, May 24 |
| » Lost to Brewers (16-21), 5-2 | County Stadium (0-1) | 21-19 | Lost 3 |
| » W: Ray Burris (2-4) L: Mike Smithson (4-4) S: Rollie Fingers (5) | Third | 2 out |
| Saturday, May 25 |
| » Lost to Brewers (17-21), 9-7 | County Stadium (0-2) | 21-20 | Lost 4 |
| » W: Bob McClure (1-0) L: Pete Filson (2-1) S: Rollie Fingers (6) | Third | 3 out |
| Sunday, May 26 |
| » Lost to Brewers (18-21), 5-3 | County Stadium (0-3) | 21-21 | Lost 5 |
| » W: Teddy Higuera (2-3) L: John Butcher (4-3) S: Bob Gibson (1) | Third | 4 out |
| Monday, May 27 |
| » Lost to Red Sox (19-24), 9-2 | Fenway Park (0-1) | 21-22 | Lost 6 |
| » W: Roger Clemens (6-4) L: Ken Schrom (3-4) S: Steve Crawford (1) | Third | 4 out |
| Wednesday, May 29 |
| » Lost to Red Sox (20-24), 7-0 | Fenway Park (0-2) | 21-23 | Lost 7 |
| » W: Oil Can Boyd (5-4) L: Frank Viola (6-4) | Fourth | 4 out |
| Thursday, May 30 |
| » Lost to Red Sox (21-24), 8-7 | Fenway Park (0-3) | 21-24 | Lost 8 |
| » W: Bob Stanley (1-2) L: Ron Davis (1-5) | Fourth | 4 out |
| Friday, May 31 |
| » Lost to Brewers (21-22), 6-4 | Hubert H. Humphrey Metrodome (15-9) | 21-25 | Lost 9 |
| » W: Teddy Higuera (3-3) L: Pete Filson (2-2) S: Rollie Fingers (8) | Fifth | 5 out |
| Saturday, June 1 |
| » Lost to Brewers (22-22), 7-2 | Hubert H. Humphrey Metrodome (15-10) | 21-26 | Lost 10 |
| » W: Danny Darwin (4-4) L: John Butcher (4-4) | Fifth | 6 out |
| Sunday, June 2 |
| » Defeated Brewers (22-23), 5-4 | Hubert H. Humphrey Metrodome (16-10) | 22-26 | |
| » W: Ken Schrom (4-4) L: Bob Gibson (5-2) | Fifth | 5 out |
| Tuesday, June 4 |
| » Lost to Blue Jays (33-16), 9-2 | Exhibition Stadium (0-1) | 22-27 | |
| » W: Jim Clancy (2-2) L: Frank Viola (6-5) | Sixth | 5½ out |
| Wednesday, June 5 |
| » Lost to Blue Jays (34-16), 5-0 | Exhibition Stadium (0-2) | 22-28 | Lost 2 |
| » W: Doyle Alexander (7-2) L: Mike Smithson (4-5) | Sixth | 5½ out |
| Friday, June 7 |
| » Defeated White Sox (25-24), 6-3 | Hubert H. Humphrey Metrodome (17-10) | 23-28 | |
| » W: Pete Filson (3-2) L: Richard Dotson (3-4) | Sixth | 4½ out |
| Saturday, June 8 |
| » Lost to White Sox (26-24), 3-1 | Hubert H. Humphrey Metrodome (17-11) | 23-29 | |
| » W: Britt Burns (7-5) L: John Butcher (4-5) S: Bob James (12) | Sixth | 5 out |
| Sunday, June 9 |
| » Lost to White Sox (27-24), 5-1 | Hubert H. Humphrey Metrodome (17-12) | 23-30 | Lost 2 |
| » W: Tom Seaver (6-4) L: Ken Schrom (4-5) | Sixth | 5½ out |
| Monday, June 10 |
| » Defeated Indians (19-37), 6-4 | Cleveland Stadium (1-0) | 24-30 | |
| » W: Frank Viola (7-5) L: Keith Creel (0-5) S: Ron Davis (6) | Sixth | 5½ out |
| Thursday, June 13 |
| » Defeated Rangers (22-37), 7-5 | Arlington Stadium (1-0) | 25-30 | Won 2 |
| » W: Mike Smithson (5-5) L: Frank Tanana (1-7) S: Rick Lysander (3) | Fifth | 5½ out |
| Friday, June 14 |
| » Lost to Rangers (23-37), 4-2 | Arlington Stadium (1-1) | 25-31 | |
| » W: Burt Hooton (3-1) L: Pete Filson (3-3) S: Dave Schmidt (1) | Fifth | 6 out |
| Saturday, June 15 |
| » Lost to Rangers (24-37), 11-2 | Arlington Stadium (1-2) | 25-32 | Lost 2 |
| » W: Mike Mason (5-6) L: John Butcher (4-6) S: Dave Stewart (4) | Sixth | 7 out |
| Sunday, June 16 |
| » Defeated Rangers (24-38), 4-1 | Arlington Stadium (2-2) | 26-32 | |
| » W: Ken Schrom (5-5) L: Charlie Hough (5-7) | Sixth | 6 out |
| Monday, June 17 |
| » Lost to Royals (31-30), 10-3 | Royals Stadium (0-1) | 26-33 | |
| » W: Bret Saberhagen (7-3) L: Frank Viola (7-6) | Fifth | 6½ out |
| Tuesday, June 18 |
| » Lost to Royals (32-30), 10-1 | Royals Stadium (0-2) | 26-34 | Lost 2 |
| » W: Mark Gubicza (4-4) L: Mike Smithson (5-6) | Sixth | 7½ out |
| Wednesday, June 19 |
| » Lost to Royals (33-30), 3-2 | Royals Stadium (0-3) | 26-35 | Lost 3 |
| » W: Danny Jackson (5-4) L: Pete Filson (3-4) S: Dan Quisenberry (13) | Sixth | 8½ out |
| Thursday, June 20 |
| » Defeated Royals (33-31), 11-8 | Royals Stadium (1-3) | 27-35 | |
| » W: Frank Eufemia (1-0) L: Joe Beckwith (1-4) S: Len Whitehouse (1) | Sixth | 7½ out |
| Friday, June 21 |
| » Defeated Rangers (26-40), 3-2 | Hubert H. Humphrey Metrodome (18-12) | 28-35 | Won 2 |
| » Manager: Ray Miller |
| » W: Ken Schrom (6-5) L: Charlie Hough (5-8) | Sixth | 7 out |
| Saturday, June 22 |
| » Defeated Rangers (26-41), 3-2 | Hubert H. Humphrey Metrodome (19-12) | 29-35 | Won 3 |
| » W: Frank Viola (8-6) L: Mike Mason (5-7) S: Ron Davis (7) | Sixth | 7 out |
| Sunday, June 23 |
| » Lost to Rangers (27-41), 3-1 | Hubert H. Humphrey Metrodome (19-13) | 29-36 | |
| » W: Glen Cook (1-0) L: Mike Smithson (5-7) S: Greg Harris (6) | Sixth | 8 out |
| Monday, June 24 |
| » Lost to Royals (34-33), 12-6 | Hubert H. Humphrey Metrodome (19-14) | 29-37 | Lost 2 |
| » W: Mark Gubicza (5-4) L: Pete Filson (3-5) | Sixth | 8 out |
| Tuesday, June 25 |
| » Lost to Royals (35-33), 3-0 | Hubert H. Humphrey Metrodome (19-15) | 29-38 | Lost 3 |
| » W: Danny Jackson (6-4) L: John Butcher (4-7) | Sixth | 9 out |
| Wednesday, June 26 |
| » Defeated Royals (35-34), 2-1 | Hubert H. Humphrey Metrodome (20-15) | 30-38 | |
| » W: Ken Schrom (7-5) L: Charlie Leibrandt (6-5) | Sixth | 9 out |
| Friday, June 28 |
| » Defeated White Sox (35-33), 5-4 | Comiskey Park I (1-0) | 31-38 | Won 2 |
| » W: Frank Viola (9-6) L: Bruce Tanner (1-2) S: Ron Davis (8) | Sixth | 8 out |
| Saturday, June 29 |
| » Defeated White Sox (35-34), 1-0 | Comiskey Park I (2-0) | 32-38 | Won 3 |
| » W: Mike Smithson (6-7) L: Britt Burns (7-6) S: Frank Eufemia (1) | Sixth | 8 out |
| Sunday, June 30 |
| » Defeated White Sox (35-35), 4-3 | Comiskey Park I (3-0) | 33-38 | Won 4 |
| » W: John Butcher (5-7) L: Tom Seaver (7-6) S: Ron Davis (9) | Sixth | 7 out |
| Monday, July 1 |
| » Lost to Indians (24-49), 5-2 | Hubert H. Humphrey Metrodome (20-16) | 33-39 | |
| » W: Vern Ruhle (2-3) L: Ken Schrom (7-6) S: Jeff Barkley (1) | Sixth | 7 out |
| Tuesday, July 2 |
| » Defeated Indians (24-50), 8-7 | Hubert H. Humphrey Metrodome (21-16) | 34-39 | |
| » W: Frank Eufemia (2-0) L: Tom Waddell (2-5) S: Pete Filson (2) | Sixth | 7 out |
| Wednesday, July 3 |
| » Defeated Indians (24-51), 7-0 | Hubert H. Humphrey Metrodome (22-16) | 35-39 | Won 2 |
| » W: Mike Smithson (7-7) L: Neal Heaton (4-10) | Sixth | 7 out |
| Thursday, July 4 |
| » Lost to Yankees (40-35), 3-2 | Yankee Stadium (0-3) | 35-40 | |
| » W: Ron Guidry (10-3) L: John Butcher (5-8) | Sixth | 8 out |
| Friday, July 5 |
| » Lost to Yankees (41-35), 6-3 | Yankee Stadium (0-4) | 35-41 | Lost 2 |
| » W: Dennis Rasmussen (3-4) L: Ken Schrom (7-7) S: Brian Fisher (4) | Sixth | 9 out |
| Sunday, July 7 |
| » Lost to Yankees (42-35), 3-2 | Yankee Stadium (0-5) | 35-42 | Lost 3 |
| » W: Dave Righetti (6-6) L: Curt Wardle (1-3) | Sixth | 10 out |
| » Lost to Yankees (43-35), 14-2 | Yankee Stadium (0-6) | 35-43 | Lost 4 |
| » W: Rich Bordi (2-2) L: Rick Lysander (0-2) | Sixth | 10 out |
| Monday, July 8 |
| » Defeated Orioles (41-38), 7-4 | Memorial Stadium (2-2) | 36-43 | |
| » W: Ron Davis (2-5) L: Don Aase (5-4) | Sixth | 10 out |
| Tuesday, July 9 |
| » Lost to Orioles (42-38), 11-6 | Memorial Stadium (2-3) | 36-44 | |
| » W: Nate Snell (3-1) L: Ken Schrom (7-8) | Sixth | 11 out |
| Wednesday, July 10 |
| » Defeated Orioles (42-39), 2-1 | Memorial Stadium (3-3) | 37-44 | |
| » W: Frank Viola (10-6) L: Mike Boddicker (9-8) S: Ron Davis (10) | Sixth | 11 out |
| Thursday, July 11 |
| » Defeated Tigers (47-35), 5-1 | Tiger Stadium (3-0) | 38-44 | Won 2 |
| » W: Mike Smithson (8-7) L: Randy O'Neal (5-2) S: Ron Davis (11) | Sixth | 10 out |
| Friday, July 12 |
| » Defeated Tigers (47-36), 3-2 | Tiger Stadium (4-0) | 39-44 | Won 3 |
| » W: John Butcher (6-8) L: Frank Tanana (4-8) S: Ron Davis (12) | Sixth | 10 out |
| » Major-league debuts: Steve Lombardozzi (Twins) |
| Saturday, July 13 |
| » Defeated Tigers (47-37), 6-4 | Tiger Stadium (5-0) | 40-44 | Won 4 |
| » W: Ken Schrom (8-8) L: Dan Petry (10-8) S: Frank Eufemia (2) | Sixth | 10 out |
| Sunday, July 14 |
| » Lost to Tigers (48-37), 8-0 | Tiger Stadium (5-1) | 40-45 | |
| » W: Walt Terrell (10-4) L: Frank Viola (10-7) S: Willie Hernandez (19) | Sixth | 11 out |
| Thursday, July 18 |
| » Defeated Yankees (49-37), 8-4 | Hubert H. Humphrey Metrodome (23-16) | 41-45 | |
| » W: Frank Eufemia (3-0) L: Rich Bordi (2-3) | Sixth | 10 out |
| Friday, July 19 |
| » Lost to Yankees (50-37), 6-4 | Hubert H. Humphrey Metrodome (23-17) | 41-46 | |
| » W: Joe Cowley (8-3) L: John Butcher (6-9) S: Dave Righetti (17) | Sixth | 11 out |
| Saturday, July 20 |
| » Lost to Yankees (51-37), 8-3 | Hubert H. Humphrey Metrodome (23-18) | 41-47 | Lost 2 |
| » W: Ron Guidry (13-3) L: Ken Schrom (8-9) | Sixth | 12 out |
| Sunday, July 21 |
| » Lost to Yankees (52-37), 5-2 | Hubert H. Humphrey Metrodome (23-19) | 41-48 | Lost 3 |
| » W: Phil Niekro (9-8) L: Frank Viola (10-8) | Sixth | 12 out |
| Monday, July 22 |
| » Defeated Orioles (46-44), 5-4 | Hubert H. Humphrey Metrodome (24-19) | 42-48 | |
| » W: Mike Smithson (9-7) L: Storm Davis (4-6) S: Ron Davis (13) | Sixth | 11 out |
| Tuesday, July 23 |
| » Defeated Orioles (46-45), 5-2 | Hubert H. Humphrey Metrodome (25-19) | 43-48 | Won 2 |
| » W: John Butcher (7-9) L: Scott McGregor (8-8) S: Ron Davis (14) | Fifth | 11 out |
| Wednesday, July 24 |
| » Lost to Orioles (47-45), 4-2 | Hubert H. Humphrey Metrodome (25-20) | 43-49 | |
| » W: Mike Boddicker (10-10) L: Ken Schrom (8-10) S: Don Aase (5) | Sixth | 12 out |
| Thursday, July 25 |
| » Lost to Tigers (51-42), 7-2 | Hubert H. Humphrey Metrodome (25-21) | 43-50 | Lost 2 |
| » W: Jack Morris (11-6) L: Frank Viola (10-9) | Sixth | 12 out |
| Friday, July 26 |
| » Defeated Tigers (51-43), 6-5 | Hubert H. Humphrey Metrodome (26-21) | 44-50 | |
| » W: Mike Smithson (10-7) L: Walt Terrell (10-5) S: Ron Davis (15) | Fifth | 11 out |
| Saturday, July 27 |
| » Defeated Tigers (51-44), 11-4 | Hubert H. Humphrey Metrodome (27-21) | 45-50 | Won 2 |
| » W: John Butcher (8-9) L: Aurelio Lopez (1-7) | Fifth | 10 out |
| Sunday, July 28 |
| » Lost to Tigers (52-44), 3-2 | Hubert H. Humphrey Metrodome (27-22) | 45-51 | |
| » W: Frank Tanana (5-10) L: Ken Schrom (8-11) S: Willie Hernandez (20) | Fifth | 10 out |
| Monday, July 29 |
| » Lost to Mariners (47-52), 8-6 | Kingdome (0-4) | 45-52 | Lost 2 |
| » W: Edwin Nunez (5-1) L: Frank Eufemia (3-1) | Sixth | 10½ out |
| Tuesday, July 30 |
| » Defeated Mariners (47-53), 12-4 | Kingdome (1-4) | 46-52 | |
| » W: Mike Smithson (11-7) L: Bill Swift (3-5) | Sixth | 9½ out |
| Wednesday, July 31 |
| » Lost to Mariners (48-53), 12-3 | Kingdome (1-5) | 46-53 | |
| » W: Jim Beattie (4-5) L: John Butcher (8-10) S: Frank Wills (1) | Sixth | 10½ out |
| Friday, August 2 |
| » Lost to Angels (58-44), 3-1 | Anaheim Stadium (2-2) | 46-54 | Lost 2 |
| » W: Kirk McCaskill (7-7) L: Ken Schrom (8-12) S: Donnie Moore (20) | Sixth | 11 out |
| Saturday, August 3 |
| » Lost to Angels (59-44), 5-4 | Anaheim Stadium (2-3) | 46-55 | Lost 3 |
| » W: Stew Cliburn (5-2) L: Bert Blyleven (9-12) | Sixth | 12 out |
| Sunday, August 4 |
| » Lost to Angels (60-44), 6-5 | Anaheim Stadium (2-4) | 46-56 | Lost 4 |
| » W: Stew Cliburn (6-2) L: Frank Eufemia (3-2) S: Donnie Moore (21) | Sixth | 13 out |
| Monday, August 5 |
| » Lost to Athletics (56-49), 5-1 | Oakland-Alameda County Stadium (1-3) | 46-57 | Lost 5 |
| » W: Tim Birtsas (8-2) L: Mike Smithson (11-8) S: Jay Howell (23) | Sixth | 14 out |
| Thursday, August 8 |
| » Defeated Angels (61-45), 4-2 | Hubert H. Humphrey Metrodome (28-22) | 47-57 | |
| » W: Bert Blyleven (10-12) L: Ron Romanick (13-5) S: Ron Davis (16) | Sixth | 13 out |
| Friday, August 9 |
| » Defeated Angels (61-46), 6-1 | Hubert H. Humphrey Metrodome (29-22) | 48-57 | Won 2 |
| » W: Frank Viola (11-9) L: Geoff Zahn (2-1) | Sixth | 12 out |
| Saturday, August 10 |
| » Lost to Angels (62-46), 9-1 | Hubert H. Humphrey Metrodome (29-23) | 48-58 | |
| » W: Kirk McCaskill (8-7) L: Mike Smithson (11-9) | Sixth | 13 out |
| Sunday, August 11 |
| » Lost to Angels (63-46), 12-0 | Hubert H. Humphrey Metrodome (29-24) | 48-59 | Lost 2 |
| » W: John Candelaria (3-4) L: John Butcher (8-11) S: Stew Cliburn (3) | Sixth | 14 out |
| Monday, August 12 |
| » Defeated Athletics (59-51), 4-3 | Hubert H. Humphrey Metrodome (30-24) | 49-59 | |
| » W: Bert Blyleven (11-12) L: Jose Rijo (0-1) | Fifth | 13 out |
| » Defeated Athletics (59-52), 5-4 | Hubert H. Humphrey Metrodome (31-24) | 50-59 | Won 2 |
| » W: Steve Howe (2-1) L: Chris Codiroli (10-9) S: Ron Davis (17) | Fifth | 13 out |
| Tuesday, August 13 |
| » Defeated Athletics (59-53), 8-1 | Hubert H. Humphrey Metrodome (32-24) | 51-59 | Won 3 |
| » W: Frank Viola (12-9) L: Tommy John (3-5) | Fifth | 12 out |
| Wednesday, August 14 |
| » Lost to Athletics (60-53), 5-0 | Hubert H. Humphrey Metrodome (32-25) | 51-60 | |
| » W: Don Sutton (12-6) L: Mike Smithson (11-10) | Sixth | 13 out |
| » Lost to Athletics (61-53), 7-4 | Hubert H. Humphrey Metrodome (32-26) | 51-61 | Lost 2 |
| » W: Jose Rijo (1-1) L: Mark Portugal (0-1) S: Steve Ontiveros (5) | Sixth | 13 out |
| » Major-league debuts: Mark Portugal (Twins) |
| Thursday, August 15 |
| » Defeated Mariners (53-62), 14-5 | Hubert H. Humphrey Metrodome (33-26) | 52-61 | |
| » W: John Butcher (9-11) L: Matt Young (7-14) | Sixth | 12½ out |
| Friday, August 16 |
| » Lost to Mariners (54-62), 6-5 | Hubert H. Humphrey Metrodome (33-27) | 52-62 | |
| » W: Ed Vande Berg (2-1) L: Steve Howe (2-2) S: Edwin Nunez (14) | Sixth | 13½ out |
| Saturday, August 17 |
| » Defeated Mariners (54-63), 2-0 | Hubert H. Humphrey Metrodome (34-27) | 53-62 | |
| » W: Bert Blyleven (12-12) L: Frank Wills (4-5) | Sixth | 13½ out |
| Sunday, August 18 |
| » Lost to Mariners (55-63), 7-2 | Hubert H. Humphrey Metrodome (34-28) | 53-63 | |
| » W: Mark Langston (7-9) L: Frank Viola (12-10) | Sixth | 13½ out |
| Monday, August 19 |
| » Lost to Brewers (53-62), 4-1 | County Stadium (0-4) | 53-64 | Lost 2 |
| » W: Danny Darwin (7-14) L: Mike Smithson (11-11) | Sixth | 14½ out |
| Tuesday, August 20 |
| » Lost to Brewers (54-62), 3-2 | County Stadium (0-5) | 53-65 | Lost 3 |
| » W: Teddy Higuera (11-6) L: Steve Howe (2-3) | Sixth | 14½ out |
| Wednesday, August 21 |
| » Lost to Brewers (55-62), 3-2 | County Stadium (0-6) | 53-66 | Lost 4 |
| » W: Ray Burris (8-9) L: Steve Howe (2-4) | Sixth | 14½ out |
| Friday, August 23 |
| » Defeated Red Sox (58-62), 5-2 | Fenway Park (1-3) | 54-66 | |
| » W: Frank Viola (13-10) L: Tim Lollar (5-8) | Sixth | 15 out |
| Saturday, August 24 |
| » Defeated Red Sox (58-63), 1-0 | Fenway Park (2-3) | 55-66 | Won 2 |
| » W: Mike Smithson (12-11) L: Bruce Hurst (8-10) | Sixth | 14 out |
| Monday, August 26 |
| » Lost to Blue Jays (78-47), 4-3 | Hubert H. Humphrey Metrodome (34-29) | 55-67 | |
| » W: Doyle Alexander (13-8) L: Bert Blyleven (12-13) S: Tom Henke (7) | Sixth | 14½ out |
| Tuesday, August 27 |
| » Lost to Blue Jays (79-47), 8-0 | Hubert H. Humphrey Metrodome (34-30) | 55-68 | Lost 2 |
| » W: Steve Davis (1-0) L: Frank Viola (13-11) | Sixth | 15½ out |
| Wednesday, August 28 |
| » Defeated Blue Jays (79-48), 6-5 | Hubert H. Humphrey Metrodome (35-30) | 56-68 | |
| » W: Pete Filson (4-5) L: Tom Henke (3-1) | Sixth | 15 out |
| Friday, August 30 |
| » Lost to Red Sox (60-66), 7-3 | Hubert H. Humphrey Metrodome (35-31) | 56-69 | |
| » W: Bob Ojeda (6-8) L: John Butcher (9-12) S: Steve Crawford (6) | Sixth | 15½ out |
| Saturday, August 31 |
| » Defeated Red Sox (60-67), 6-5 | Hubert H. Humphrey Metrodome (36-31) | 57-69 | |
| » W: Bert Blyleven (13-13) L: Steve Crawford (5-4) | Fifth | 14 out |
| » Defeated Red Sox (60-68), 5-4 | Hubert H. Humphrey Metrodome (37-31) | 58-69 | Won 2 |
| » W: Mark Portugal (1-1) L: Al Nipper (7-10) S: Ron Davis (18) | Fifth | 14 out |
| Sunday, September 1 |
| » Lost to Red Sox (61-68), 10-3 | Hubert H. Humphrey Metrodome (37-32) | 58-70 | |
| » W: Mike Trujillo (4-3) L: Frank Viola (13-12) | Sixth | 14 out |
| Monday, September 2 |
| » Defeated Brewers (59-69), 6-1 | Hubert H. Humphrey Metrodome (38-32) | 59-70 | |
| » W: Mike Smithson (13-11) L: Jaime Cocanower (4-4) S: Ron Davis (19) | Sixth | 14 out |
| Tuesday, September 3 |
| » Defeated Brewers (59-70), 4-3 | Hubert H. Humphrey Metrodome (39-32) | 60-70 | Won 2 |
| » W: Steve Howe (3-4) L: Danny Darwin (7-16) | Fifth | 13 out |
| Wednesday, September 4 |
| » Lost to Brewers (60-70), 11-10 | Hubert H. Humphrey Metrodome (39-33) | 60-71 | |
| » W: Rick Waits (3-2) L: Dennis Burtt (0-1) S: Rollie Fingers (17) | Fifth | 14 out |
| Thursday, September 5 |
| » Lost to Blue Jays (83-50), 7-0 | Exhibition Stadium (0-3) | 60-72 | Lost 2 |
| » W: Doyle Alexander (14-8) L: Bert Blyleven (13-14) | Fifth | 14½ out |
| Friday, September 6 |
| » Lost to Blue Jays (84-50), 8-3 | Exhibition Stadium (0-4) | 60-73 | Lost 3 |
| » W: Steve Davis (2-1) L: Frank Viola (13-13) | Sixth | 15 out |
| Saturday, September 7 |
| » Defeated Blue Jays (84-51), 6-3 | Exhibition Stadium (1-4) | 61-73 | |
| » W: Mike Smithson (14-11) L: Dave Stieb (13-10) | Sixth | 15 out |
| Sunday, September 8 |
| » Lost to Blue Jays (85-51), 10-9 | Exhibition Stadium (1-5) | 61-74 | |
| » W: Dennis Lamp (8-0) L: Mark Portugal (1-2) S: Gary Lavelle (6) | Sixth | 16 out |
| Monday, September 9 |
| » Defeated White Sox (68-68), 5-0 | Comiskey Park I (4-0) | 62-74 | |
| » W: John Butcher (10-12) L: Floyd Bannister (6-13) | Sixth | 15 out |
| Tuesday, September 10 |
| » Lost to White Sox (69-68), 7-2 | Comiskey Park I (4-1) | 62-75 | |
| » W: Joel Davis (3-2) L: Bert Blyleven (13-15) S: Bob James (25) | Sixth | 16 out |
| Wednesday, September 11 |
| » Lost to White Sox (70-68), 5-0 | Comiskey Park I (4-2) | 62-76 | Lost 2 |
| » W: Britt Burns (17-8) L: Frank Viola (13-14) | Sixth | 17 out |
| Thursday, September 12 |
| » Lost to White Sox (71-68), 4-2 | Comiskey Park I (4-3) | 62-77 | Lost 3 |
| » W: Gene Nelson (9-9) L: Mike Smithson (14-12) S: Bob James (26) | Sixth | 17½ out |
| Friday, September 13 |
| » Lost to Indians (51-90), 3-2 | Cleveland Stadium (1-1) | 62-78 | Lost 4 |
| » W: Curt Wardle (7-7) L: Mark Portugal (1-3) S: Jerry Reed (6) | Sixth | 18 out |
| » Defeated Indians (51-91), 3-1 | Cleveland Stadium (2-1) | 63-78 | |
| » W: Frank Viola (14-14) L: Don Schulze (3-8) S: Ron Davis (20) | Sixth | 18 out |
| » Major-league debuts: Jim Wilson (Indians) |
| Saturday, September 14 |
| » Lost to Indians (52-91), 11-9 | Cleveland Stadium (2-2) | 63-79 | |
| » W: Tom Waddell (8-6) L: John Butcher (10-13) S: Jerry Reed (7) | Sixth | 18½ out |
| » Defeated Indians (52-92), 5-3 | Cleveland Stadium (3-2) | 64-79 | |
| » W: Dennis Burtt (1-1) L: Rich Thompson (3-8) S: Ron Davis (21) | Sixth | 18½ out |
| Sunday, September 15 |
| » Defeated Indians (52-93), 5-2 | Cleveland Stadium (4-2) | 65-79 | Won 2 |
| » W: Bert Blyleven (14-15) L: Roy Smith (1-4) S: Ron Davis (22) | Sixth | 18 out |
| Monday, September 16 |
| » Defeated Rangers (52-91), 7-6 | Hubert H. Humphrey Metrodome (40-33) | 66-79 | Won 3 |
| » W: Frank Eufemia (4-2) L: Greg Harris (4-4) | Sixth | 17 out |
| Tuesday, September 17 |
| » Defeated Rangers (52-92), 7-2 | Hubert H. Humphrey Metrodome (41-33) | 67-79 | Won 4 |
| » W: Frank Viola (15-14) L: Dave Schmidt (5-5) | Sixth | 16 out |
| Wednesday, September 18 |
| » Defeated Rangers (52-93), 4-3 | Hubert H. Humphrey Metrodome (42-33) | 68-79 | Won 5 |
| » W: Ken Schrom (9-12) L: Charlie Hough (14-16) S: Ron Davis (23) | Sixth | 15 out |
| Friday, September 20 |
| » Lost to Royals (83-64), 5-1 | Royals Stadium (1-4) | 68-80 | |
| » W: Charlie Leibrandt (16-8) L: Bert Blyleven (14-16) | Fifth | 15½ out |
| Saturday, September 21 |
| » Lost to Royals (84-64), 6-5 | Royals Stadium (1-5) | 68-81 | Lost 2 |
| » W: Mark Huismann (1-0) L: Ron Davis (2-6) | Fifth | 16½ out |
| Sunday, September 22 |
| » Defeated Royals (84-65), 7-3 | Royals Stadium (2-5) | 69-81 | |
| » W: Frank Viola (16-14) L: Danny Jackson (13-11) | Sixth | 16½ out |
| Tuesday, September 24 |
| » Lost to Rangers (57-93), 5-0 | Arlington Stadium (2-3) | 69-82 | |
| » W: Matt Williams (2-0) L: John Butcher (10-14) | Sixth | 16 out |
| Wednesday, September 25 |
| » Defeated Rangers (57-94), 5-1 | Arlington Stadium (3-3) | 70-82 | |
| » W: Bert Blyleven (15-16) L: Jeff Russell (2-6) | Sixth | 16 out |
| Thursday, September 26 |