| Wednesday, January 16 |
| Former Red Sox Ken Chase dies in Oneonta, NY at the age of 72. |
| Monday, April 8 |
| » Defeated Yankees (0-1), 9-2 | Fenway Park (1-0) | 1-0 | |
| » W: Oil Can Boyd (1-0) L: Phil Niekro (0-1) | First | -- |
| Wednesday, April 10 |
| » Defeated Yankees (0-2), 14-5 | Fenway Park (2-0) | 2-0 | Won 2 |
| » W: Bruce Hurst (1-0) L: Ed Whitson (0-1) | First | -- |
| Thursday, April 11 |
| » Defeated Yankees (0-3), 6-4 | Fenway Park (3-0) | 3-0 | Won 3 |
| » W: Roger Clemens (1-0) L: Dennis Rasmussen (0-1) S: Bob Stanley (1) | First | -- |
| Saturday, April 13 |
| » Defeated White Sox (1-2), 7-2 | Fenway Park (4-0) | 4-0 | Won 4 |
| » W: Oil Can Boyd (2-0) L: Floyd Bannister (0-1) | First | -- |
| Sunday, April 14 |
| » Lost to White Sox (2-2), 11-6 | Fenway Park (4-1) | 4-1 | |
| » W: Britt Burns (1-0) L: Steve Crawford (0-1) | Second | 1 out |
| » Major-league debuts: Mike Trujillo (Red Sox) |
| Monday, April 15 |
| » Lost to White Sox (3-2), 6-5 | Fenway Park (4-2) | 4-2 | Lost 2 |
| » W: Al Jones (1-0) L: Bob Stanley (0-1) | Third | 1½ out |
| » Major-league debuts: Steve Lyons (Red Sox) |
| Tuesday, April 16 |
| » Lost to Royals (2-4), 2-0 | Royals Stadium (0-1) | 4-3 | Lost 3 |
| » W: Danny Jackson (1-0) L: Roger Clemens (1-1) | Third | 2½ out |
| Wednesday, April 17 |
| » Lost to Royals (3-4), 6-1 | Royals Stadium (0-2) | 4-4 | Lost 4 |
| » W: Charlie Leibrandt (1-0) L: Al Nipper (0-1) | Fourth | 2½ out |
| Thursday, April 18 |
| » Defeated Royals (3-5), 4-3 | Royals Stadium (1-2) | 5-4 | |
| » W: Bob Ojeda (1-0) L: Mike Jones (0-1) | Fifth | 2 out |
| Friday, April 19 |
| » Lost to White Sox (4-4), 8-1 | Comiskey Park I (0-1) | 5-5 | |
| » W: Britt Burns (2-0) L: Mike Trujillo (0-1) | Sixth | 2 out |
| Saturday, April 20 |
| » Defeated White Sox (4-5), 12-8 | Comiskey Park I (1-1) | 6-5 | |
| » W: Steve Crawford (1-1) L: Gene Nelson (0-1) S: Bob Stanley (2) | Fourth | 2 out |
| Sunday, April 21 |
| » Lost to White Sox (5-5), 7-2 | Comiskey Park I (1-2) | 6-6 | |
| » W: Tim Lollar (1-1) L: Roger Clemens (1-2) | Fifth | 2 out |
| Tuesday, April 23 |
| » Defeated Yankees (5-6), 5-4 | Yankee Stadium (1-0) | 7-6 | |
| » W: Bob Ojeda (2-0) L: Dave Righetti (1-1) | Second | 1½ out |
| Wednesday, April 24 |
| » Defeated Yankees (5-7), 7-6 | Yankee Stadium (2-0) | 8-6 | Won 2 |
| » W: Steve Crawford (2-1) L: Ron Guidry (1-2) S: Bob Stanley (3) | Second | ½ out |
| Thursday, April 25 |
| » Lost to Yankees (6-7), 5-1 | Yankee Stadium (2-1) | 8-7 | |
| » W: Phil Niekro (3-1) L: Bruce Hurst (1-1) S: Dave Righetti (5) | Third | 1 out |
| Friday, April 26 |
| » Defeated Royals (7-8), 5-2 | Fenway Park (5-2) | 9-7 | |
| » W: Roger Clemens (2-2) L: Mark Gubicza (0-1) | Third | 1 out |
| Saturday, April 27 |
| » Lost to Royals (8-8), 5-4 | Fenway Park (5-3) | 9-8 | |
| » W: Dan Quisenberry (2-2) L: Bob Stanley (0-2) | Third | 1½ out |
| Sunday, April 28 |
| » Lost to Royals (9-8), 5-2 | Fenway Park (5-4) | 9-9 | Lost 2 |
| » W: Charlie Leibrandt (3-0) L: Oil Can Boyd (2-1) S: Joe Beckwith (1) | Third | 2½ out |
| Monday, April 29 |
| » Lost to Angels (13-7), 7-6 | Anaheim Stadium (0-1) | 9-10 | Lost 3 |
| » W: Pat Clements (1-0) L: Steve Crawford (2-2) S: Donnie Moore (4) | Fourth | 3 out |
| Tuesday, April 30 |
| » Lost to Angels (14-7), 3-2 | Anaheim Stadium (0-2) | 9-11 | Lost 4 |
| » W: Stew Cliburn (1-0) L: Bob Ojeda (2-1) | Fourth | 4 out |
| Wednesday, May 1 |
| » Lost to Mariners (10-12), 7-0 | Kingdome (0-1) | 9-12 | Lost 5 |
| » W: Jim Beattie (1-2) L: Roger Clemens (2-3) | Fifth | 5 out |
| Thursday, May 2 |
| » Defeated Mariners (10-13), 2-1 | Kingdome (1-1) | 10-12 | |
| » W: Al Nipper (1-1) L: Mike Moore (2-3) S: Bob Stanley (4) | Fourth | 4 out |
| Friday, May 3 |
| » Defeated Athletics (10-14), 10-0 | Oakland-Alameda County Stadium (1-0) | 11-12 | Won 2 |
| » W: Oil Can Boyd (3-1) L: Mike Warren (1-3) | Fourth | 4 out |
| Saturday, May 4 |
| » Defeated Athletics (10-15), 5-4 | Oakland-Alameda County Stadium (2-0) | 12-12 | Won 3 |
| » W: Steve Crawford (3-2) L: Bill Krueger (2-3) S: Bob Ojeda (1) | Fourth | 3 out |
| Sunday, May 5 |
| » Lost to Athletics (11-15), 6-3 | Oakland-Alameda County Stadium (2-1) | 12-13 | |
| » W: Chris Codiroli (3-1) L: Bruce Hurst (1-2) S: Jay Howell (7) | Fourth | 4 out |
| Monday, May 6 |
| Former Red Sox Joe Glenn dies in Tunkhannock, PA at the age of 77. |
| Tuesday, May 7 |
| » Defeated Angels (17-10), 6-4 | Fenway Park (6-4) | 13-13 | |
| » W: Roger Clemens (3-3) L: Kirk McCaskill (0-2) S: Bob Stanley (5) | Fourth | 4 out |
| Wednesday, May 8 |
| » Defeated Angels (17-11), 6-1 | Fenway Park (7-4) | 14-13 | Won 2 |
| » W: Oil Can Boyd (4-1) L: Jim Slaton (3-1) | Fourth | 3 out |
| Friday, May 10 |
| » Defeated Athletics (12-17), 5-4 | Fenway Park (8-4) | 15-13 | Won 3 |
| » W: Mark Clear (1-0) L: Jay Howell (0-2) | Fourth | 3 out |
| Saturday, May 11 |
| » Lost to Athletics (13-17), 12-1 | Fenway Park (8-5) | 15-14 | |
| » W: Bill Krueger (3-3) L: Bruce Hurst (1-3) | Fourth | 4 out |
| Sunday, May 12 |
| » Lost to Athletics (14-17), 5-3 | Fenway Park (8-6) | 15-15 | Lost 2 |
| » W: Don Sutton (3-3) L: Roger Clemens (3-4) S: Jay Howell (9) | Fourth | 4 out |
| Tuesday, May 14 |
| » Lost to Mariners (14-18), 5-0 | Fenway Park (8-7) | 15-16 | Lost 3 |
| » W: Mike Moore (4-3) L: Oil Can Boyd (4-2) | Fourth | 5 out |
| Wednesday, May 15 |
| » Lost to Mariners (15-18), 7-1 | Fenway Park (8-8) | 15-17 | Lost 4 |
| » W: Mark Langston (5-3) L: Al Nipper (1-2) | Fifth | 5 out |
| Friday, May 17 |
| » Defeated Indians (12-22), 5-0 | Cleveland Stadium (1-0) | 16-17 | |
| » W: Roger Clemens (4-4) L: Bert Blyleven (2-4) | Fourth | 4 out |
| Saturday, May 18 |
| » Lost to Indians (13-22), 4-1 | Cleveland Stadium (1-1) | 16-18 | |
| » W: Neal Heaton (3-3) L: Bruce Hurst (1-4) S: Tom Waddell (7) | Fifth | 5 out |
| Sunday, May 19 |
| » Lost to Indians (14-22), 2-1 | Cleveland Stadium (1-2) | 16-19 | Lost 2 |
| » W: Rich Thompson (1-1) L: Oil Can Boyd (4-3) | Fourth | 5 out |
| Monday, May 20 |
| » Lost to Twins (21-16), 5-2 | Hubert H. Humphrey Metrodome (0-1) | 16-20 | Lost 3 |
| » W: John Butcher (4-2) L: Al Nipper (1-3) S: Curt Wardle (1) | Fifth | 6 out |
| Tuesday, May 21 |
| » Defeated Twins (21-17), 9-1 | Hubert H. Humphrey Metrodome (1-1) | 17-20 | |
| » W: Bruce Kison (1-0) L: Ken Schrom (3-3) | Fifth | 6 out |
| Former Red Sox Archie McKain dies in Salina, KS at the age of 75. |
| Wednesday, May 22 |
| » Defeated Twins (21-18), 4-3 | Hubert H. Humphrey Metrodome (2-1) | 18-20 | Won 2 |
| » W: Roger Clemens (5-4) L: Frank Viola (6-3) S: Bob Stanley (6) | Fifth | 6 out |
| Thursday, May 23 |
| » Lost to Rangers (12-27), 7-6 | Arlington Stadium (0-1) | 18-21 | |
| » W: Dave Rozema (2-3) L: Mark Clear (1-1) | Fifth | 7 out |
| Friday, May 24 |
| » Lost to Rangers (13-27), 1-0 | Arlington Stadium (0-2) | 18-22 | Lost 2 |
| » W: Charlie Hough (4-3) L: Oil Can Boyd (4-4) | Fifth | 8 out |
| Saturday, May 25 |
| » Lost to Rangers (14-27), 10-3 | Arlington Stadium (0-3) | 18-23 | Lost 3 |
| » W: Mike Mason (3-4) L: Al Nipper (1-4) S: Greg Harris (3) | Sixth | 9 out |
| Sunday, May 26 |
| » Lost to Rangers (15-27), 5-3 | Arlington Stadium (0-4) | 18-24 | Lost 4 |
| » W: Frank Tanana (1-5) L: Bruce Kison (1-1) S: Dave Rozema (3) | Sixth | 10 out |
| Monday, May 27 |
| » Defeated Twins (21-22), 9-2 | Fenway Park (9-8) | 19-24 | |
| » W: Roger Clemens (6-4) L: Ken Schrom (3-4) S: Steve Crawford (1) | Sixth | 9½ out |
| Wednesday, May 29 |
| » Defeated Twins (21-23), 7-0 | Fenway Park (10-8) | 20-24 | Won 2 |
| » W: Oil Can Boyd (5-4) L: Frank Viola (6-4) | Sixth | 9 out |
| Thursday, May 30 |
| » Defeated Twins (21-24), 8-7 | Fenway Park (11-8) | 21-24 | Won 3 |
| » W: Bob Stanley (1-2) L: Ron Davis (1-5) | Sixth | 8½ out |
| Friday, May 31 |
| » Lost to Rangers (17-29), 3-1 | Fenway Park (11-9) | 21-25 | |
| » W: Mike Mason (4-4) L: Al Nipper (1-5) S: Dave Stewart (3) | Sixth | 9½ out |
| Saturday, June 1 |
| » Defeated Rangers (17-30), 6-0 | Fenway Park (12-9) | 22-25 | |
| » W: Bruce Kison (2-1) L: Frank Tanana (1-6) | Fifth | 9½ out |
| Sunday, June 2 |
| » Defeated Rangers (17-31), 12-3 | Fenway Park (13-9) | 23-25 | Won 2 |
| » W: Bruce Hurst (2-4) L: Dave Rozema (2-4) | Sixth | 9 out |
| Monday, June 3 |
| » Defeated Indians (17-33), 6-5 | Fenway Park (14-9) | 24-25 | Won 3 |
| » W: Oil Can Boyd (6-4) L: Don Schulze (3-5) | Fourth | 8½ out |
| Tuesday, June 4 |
| » Defeated Indians (17-34), 5-0 | Fenway Park (15-9) | 25-25 | Won 4 |
| » W: Bob Ojeda (3-1) L: Keith Creel (0-4) | Fourth | 8½ out |
| Friday, June 7 |
| » Defeated Orioles (29-22), 8-4 | Memorial Stadium (1-0) | 26-25 | Won 5 |
| » W: Al Nipper (2-5) L: Mike Boddicker (6-5) | Fifth | 9½ out |
| Saturday, June 8 |
| » Defeated Orioles (29-23), 2-1 | Memorial Stadium (2-0) | 27-25 | Won 6 |
| » W: Bruce Kison (3-1) L: Scott McGregor (4-5) S: Bob Stanley (7) | Fifth | 8½ out |
| Sunday, June 9 |
| » Defeated Orioles (29-24), 12-0 | Memorial Stadium (3-0) | 28-25 | Won 7 |
| » W: Oil Can Boyd (7-4) L: Storm Davis (3-2) | Third | 7½ out |
| Monday, June 10 |
| » Defeated Brewers (26-26), 4-2 | Fenway Park (16-9) | 29-25 | Won 8 |
| » W: Bob Ojeda (4-1) L: Teddy Higuera (4-4) | Third | 6½ out |
| Tuesday, June 11 |
| » Lost to Brewers (27-26), 5-3 | Fenway Park (16-10) | 29-26 | |
| » W: Danny Darwin (6-4) L: Bruce Hurst (2-5) S: Bob Gibson (3) | Fourth | 7½ out |
| Wednesday, June 12 |
| » Defeated Brewers (27-27), 7-2 | Fenway Park (17-10) | 30-26 | |
| » W: Al Nipper (3-5) L: Moose Haas (5-3) | Third | 7½ out |
| Thursday, June 13 |
| » Defeated Blue Jays (38-20), 8-7 | Fenway Park (18-10) | 31-26 | Won 2 |
| » W: Mike Trujillo (1-1) L: Gary Lavelle (2-1) S: Bob Stanley (8) | Third | 6½ out |
| Friday, June 14 |
| » Defeated Blue Jays (38-21), 4-1 | Fenway Park (19-10) | 32-26 | Won 3 |
| » W: Oil Can Boyd (8-4) L: Jim Clancy (2-4) | Third | 5½ out |
| Saturday, June 15 |
| » Defeated Blue Jays (38-22), 7-5 | Fenway Park (20-10) | 33-26 | Won 4 |
| » W: Bob Stanley (2-2) L: Jim Acker (3-1) | Third | 4½ out |
| Sunday, June 16 |
| » Defeated Blue Jays (38-23), 7-6 | Fenway Park (21-10) | 34-26 | Won 5 |
| » W: Steve Crawford (4-2) L: Gary Lavelle (2-2) | Third | 3½ out |
| Monday, June 17 |
| » Defeated Tigers (33-26), 3-2 | Tiger Stadium (1-0) | 35-26 | Won 6 |
| » W: Al Nipper (4-5) L: Willie Hernandez (4-3) | Second | 2½ out |
| Tuesday, June 18 |
| » Lost to Tigers (34-26), 9-8 | Tiger Stadium (1-1) | 35-27 | |
| » W: Juan Berenguer (2-3) L: Bruce Hurst (2-6) S: Aurelio Lopez (4) | Third | 2½ out |
| Wednesday, June 19 |
| » Lost to Tigers (35-26), 9-3 | Tiger Stadium (1-2) | 35-28 | Lost 2 |
| » W: Walt Terrell (8-2) L: Oil Can Boyd (8-5) S: Aurelio Lopez (5) | Third | 3½ out |
| Thursday, June 20 |
| » Lost to Blue Jays (40-25), 6-5 | Exhibition Stadium (0-1) | 35-29 | Lost 3 |
| » W: Jim Acker (4-1) L: Bob Stanley (2-3) S: Bill Caudill (11) | Third | 4½ out |
| Friday, June 21 |
| » Lost to Blue Jays (41-25), 7-2 | Exhibition Stadium (0-2) | 35-30 | Lost 4 |
| » W: Jimmy Key (5-2) L: Bruce Hurst (2-7) | Third | 5½ out |
| Saturday, June 22 |
| » Defeated Blue Jays (41-26), 5-3 | Exhibition Stadium (1-2) | 36-30 | |
| » W: Bob Stanley (3-3) L: Jim Acker (4-2) | Third | 4½ out |
| Sunday, June 23 |
| » Lost to Blue Jays (42-26), 8-1 | Exhibition Stadium (1-3) | 36-31 | |
| » W: Dave Stieb (7-5) L: Bruce Kison (3-2) | Fourth | 5½ out |
| Monday, June 24 |
| » Defeated Tigers (38-28), 9-2 | Fenway Park (22-10) | 37-31 | |
| » W: Oil Can Boyd (9-5) L: Walt Terrell (8-3) | Third | 5 out |
| Tuesday, June 25 |
| » Lost to Tigers (39-28), 3-0 | Fenway Park (22-11) | 37-32 | |
| » W: Jack Morris (9-5) L: Bob Ojeda (4-2) | Third | 6 out |
| Wednesday, June 26 |
| » Lost to Tigers (40-28), 3-0 | Fenway Park (22-12) | 37-33 | Lost 2 |
| » W: Randy O'Neal (3-1) L: Al Nipper (4-6) S: Willie Hernandez (16) | Third | 6 out |
| Friday, June 28 |
| » Defeated Orioles (35-34), 6-1 | Fenway Park (23-12) | 38-33 | |
| » W: Bruce Hurst (3-7) L: Storm Davis (4-4) | Fourth | 6½ out |
| Saturday, June 29 |
| » Lost to Orioles (36-34), 16-4 | Fenway Park (23-13) | 38-34 | |
| » W: Dennis Martinez (6-5) L: Oil Can Boyd (9-6) S: Nate Snell (3) | Fourth | 6½ out |
| Sunday, June 30 |
| » Lost to Orioles (37-34), 3-0 | Fenway Park (23-14) | 38-35 | Lost 2 |
| » W: Mike Boddicker (8-7) L: Bob Ojeda (4-3) | Third | 7½ out |
| Monday, July 1 |
| » Lost to Brewers (34-37), 5-1 | County Stadium (0-1) | 38-36 | Lost 3 |
| » W: Pete Vuckovich (3-5) L: Mike Trujillo (1-2) S: Bob Gibson (5) | Fourth | 7½ out |
| Tuesday, July 2 |
| » Lost to Brewers (35-37), 4-3 | County Stadium (0-2) | 38-37 | Lost 4 |
| » W: Rollie Fingers (1-3) L: Bob Stanley (3-4) | Fifth | 7½ out |
| Wednesday, July 3 |
| » Defeated Brewers (35-38), 9-0 | County Stadium (1-2) | 39-37 | |
| » W: Bruce Hurst (4-7) L: Danny Darwin (6-8) | Fifth | 7½ out |
| Thursday, July 4 |
| » Lost to Angels (44-33), 5-4 | Anaheim Stadium (0-3) | 39-38 | |
| » W: Pat Clements (5-0) L: Oil Can Boyd (9-7) S: Donnie Moore (16) | Fifth | 7½ out |
| Friday, July 5 |
| » Lost to Angels (45-33), 13-4 | Anaheim Stadium (0-4) | 39-39 | Lost 2 |
| » W: Ron Romanick (9-4) L: Bob Ojeda (4-4) S: Pat Clements (1) | Fifth | 8½ out |
| » Major-league debuts: Tom McCarthy (Red Sox) |
| Saturday, July 6 |
| » Defeated Angels (45-34), 7-5 | Anaheim Stadium (1-4) | 40-39 | |
| » W: Bob Stanley (4-4) L: Stew Cliburn (3-2) | Fifth | 7½ out |
| Sunday, July 7 |
| » Lost to Angels (46-34), 8-3 | Anaheim Stadium (1-5) | 40-40 | |
| » W: Kirk McCaskill (4-5) L: Jim Dorsey (0-1) | Fifth | 8½ out |
| Monday, July 8 |
| » Defeated Athletics (42-39), 2-1 | Oakland-Alameda County Stadium (3-1) | 41-40 | |
| » W: Bruce Hurst (5-7) L: Chris Codiroli (8-5) S: Steve Crawford (2) | Fifth | 8½ out |
| Tuesday, July 9 |
| » Defeated Athletics (42-40), 6-3 | Oakland-Alameda County Stadium (4-1) | 42-40 | Won 2 |
| » W: Oil Can Boyd (10-7) L: Steve Ontiveros (0-1) | Fifth | 8½ out |
| Wednesday, July 10 |
| » Lost to Athletics (43-40), 5-4 | Oakland-Alameda County Stadium (4-2) | 42-41 | |
| » W: Bill Krueger (6-8) L: Bob Ojeda (4-5) S: Jay Howell (18) | Fifth | 9½ out |
| Thursday, July 11 |
| » Defeated Mariners (41-43), 7-1 | Kingdome (2-1) | 43-41 | |
| » W: Al Nipper (5-6) L: Bill Swift (3-3) S: Steve Crawford (3) | Fifth | 9½ out |
| Friday, July 12 |
| » Defeated Mariners (41-44), 5-4 | Kingdome (3-1) | 44-41 | Won 2 |
| » W: Mike Trujillo (2-2) L: Edwin Nunez (4-1) S: Mark Clear (1) | Fourth | 8½ out |
| Saturday, July 13 |
| » Lost to Mariners (42-44), 6-5 | Kingdome (3-2) | 44-42 | |
| » W: Brian Snyder (1-2) L: Bob Stanley (4-5) | Fifth | 8½ out |
| Sunday, July 14 |
| » Defeated Mariners (42-45), 6-2 | Kingdome (4-2) | 45-42 | |
| » W: Oil Can Boyd (11-7) L: Frank Wills (4-3) | Fifth | 7½ out |
| Thursday, July 18 |
| » Defeated Angels (52-36), 10-1 | Fenway Park (24-14) | 46-42 | Won 2 |
| » W: Bruce Hurst (6-7) L: Kirk McCaskill (5-6) | Fourth | 6½ out |
| Friday, July 19 |
| » Lost to Angels (53-36), 3-2 | Fenway Park (24-15) | 46-43 | |
| » W: Ron Romanick (11-4) L: Oil Can Boyd (11-8) S: Donnie Moore (18) | Fourth | 7½ out |
| Saturday, July 20 |
| » Lost to Angels (54-36), 5-3 | Fenway Park (24-16) | 46-44 | Lost 2 |
| » W: Mike Witt (8-6) L: Bob Ojeda (4-6) S: Donnie Moore (19) | Fourth | 7½ out |
| Sunday, July 21 |
| » Defeated Angels (54-37), 8-4 | Fenway Park (25-16) | 47-44 | |
| » W: Al Nipper (6-6) L: Urbano Lugo (3-2) | Fifth | 7½ out |
| Monday, July 22 |
| » Defeated Athletics (48-44), 6-4 | Fenway Park (26-16) | 48-44 | Won 2 |
| » W: Tim Lollar (4-5) L: Chris Codiroli (8-7) S: Bob Stanley (9) | Fourth | 7½ out |
| Tuesday, July 23 |
| » Defeated Athletics (48-45), 3-2 | Fenway Park (27-16) | 49-44 | Won 3 |
| » W: Bruce Hurst (7-7) L: Rick Langford (0-3) | Fourth | 7½ out |
| Wednesday, July 24 |
| » Defeated Athletics (48-46), 6-5 | Fenway Park (28-16) | 50-44 | Won 4 |
| » W: Bob Stanley (5-5) L: Jay Howell (8-4) | Fourth | 7½ out |
| Thursday, July 25 |
| » Defeated Mariners (44-51), 5-3 | Fenway Park (29-16) | 51-44 | Won 5 |
| » W: Bob Ojeda (5-6) L: Bill Swift (3-4) S: Mark Clear (2) | Fourth | 7½ out |
| Friday, July 26 |
| » Defeated Mariners (44-52), 6-2 | Fenway Park (30-16) | 52-44 | Won 6 |
| » W: Al Nipper (7-6) L: Jim Beattie (3-5) S: Bob Stanley (10) | Fourth | 7½ out |
| Saturday, July 27 |
| » Lost to Mariners (45-52), 10-3 | Fenway Park (30-17) | 52-45 | |
| » W: Roy Thomas (5-0) L: Tim Lollar (4-6) | Fourth | 8½ out |
| Former Red Sox Joe Wood dies in West Haven, CT at the age of 96. |
| Sunday, July 28 |
| » Lost to Mariners (46-52), 7-2 | Fenway Park (30-18) | 52-46 | Lost 2 |
| » W: Mike Moore (9-6) L: Bruce Hurst (7-8) | Fourth | 9½ out |
| Tuesday, July 30 |
| » Lost to White Sox (49-47), 7-5 | Fenway Park (30-19) | 52-47 | Lost 3 |
| » W: Tom Seaver (11-8) L: Oil Can Boyd (11-9) S: Juan Agosto (1) | Fourth | 10 out |
| Wednesday, July 31 |
| » Tied White Sox, 1-1 | Fenway Park (30-19) | 52-47 | |
| » Starters: Floyd Bannister vs Bob Ojeda | Fourth | 10½ out |
| Thursday, August 1 |
| » Lost to White Sox (50-47), 7-2 | Fenway Park (30-20) | 52-48 | Lost 4 |
| » W: Gene Nelson (7-5) L: Al Nipper (7-7) | Fourth | 11 out |
| » Defeated White Sox (50-48), 4-3 | Fenway Park (31-20) | 53-48 | |
| » W: Steve Crawford (5-2) L: Juan Agosto (2-2) | Fourth | 11 out |
| Friday, August 2 |
| » Lost to Royals (55-45), 4-3 | Royals Stadium (1-3) | 53-49 | |
| » W: Dan Quisenberry (5-6) L: Mark Clear (1-2) | Fourth | 12 out |
| Saturday, August 3 |
| » Defeated Royals (55-46), 5-4 | Royals Stadium (2-3) | 54-49 | |
| » W: Roger Clemens (7-4) L: Mark Gubicza (7-6) S: Steve Crawford (4) | Fourth | 12 out |
| Sunday, August 4 |
| » Defeated Royals (55-47), 6-5 | Royals Stadium (3-3) | 55-49 | Won 2 |
| » W: Bob Stanley (6-5) L: Mike LaCoss (1-1) S: Mark Clear (3) | Third | 11 out |
| Thursday, August 8 |
| » Lost to White Sox (53-50), 7-6 | Comiskey Park I (1-3) | 55-50 | |
| » W: Dave Wehrmeister (1-0) L: Bruce Kison (3-3) S: Bob James (18) | Fourth | 12 out |
| » Defeated White Sox (53-51), 6-1 | Comiskey Park I (2-3) | 56-50 | |
| » W: Tim Lollar (5-6) L: Gene Nelson (7-6) S: Steve Crawford (5) | Fourth | 12 out |
| Friday, August 9 |
| » Lost to Yankees (60-47), 10-6 | Fenway Park (31-21) | 56-51 | |
| » W: Rich Bordi (3-4) L: Bruce Hurst (7-9) | Fourth | 12 out |
| Saturday, August 10 |
| » Lost to Yankees (61-47), 7-3 | Fenway Park (31-22) | 56-52 | Lost 2 |
| » W: Joe Cowley (10-5) L: Oil Can Boyd (11-10) S: Dave Righetti (21) | Fourth | 12 out |
| Sunday, August 11 |
| » Lost to Yankees (62-47), 5-3 | Fenway Park (31-23) | 56-53 | Lost 3 |
| » W: Ron Guidry (15-4) L: Roger Clemens (7-5) S: Brian Fisher (5) | Fourth | 13 out |
| Monday, August 12 |
| » Lost to Royals (60-49), 3-2 | Fenway Park (31-24) | 56-54 | Lost 4 |
| » W: Mark Gubicza (9-6) L: Al Nipper (7-8) S: Dan Quisenberry (26) | Fourth | 13 out |
| Tuesday, August 13 |
| » Lost to Royals (61-49), 6-3 | Fenway Park (31-25) | 56-55 | Lost 5 |
| » W: Bret Saberhagen (14-5) L: Bob Ojeda (5-7) S: Dan Quisenberry (27) | Fifth | 14 out |
| Wednesday, August 14 |
| » Defeated Royals (61-50), 16-3 | Fenway Park (32-25) | 57-55 | |
| » W: Bruce Hurst (8-9) L: Bud Black (8-12) | Fifth | 14 out |
| Friday, August 16 |
| » Lost to Yankees (65-48), 5-4 | Yankee Stadium (2-2) | 57-56 | |
| » W: Dave Righetti (8-7) L: Steve Crawford (5-3) | Fifth | 14 out |
| Saturday, August 17 |
| » Lost to Yankees (66-48), 3-1 | Yankee Stadium (2-3) | 57-57 | Lost 2 |
| » W: Ron Guidry (16-4) L: Al Nipper (7-9) S: Brian Fisher (6) | Fifth | 14 out |
| Sunday, August 18 |
| » Lost to Yankees (67-48), 4-2 | Yankee Stadium (2-4) | 57-58 | Lost 3 |
| » W: Dave Righetti (9-7) L: Tim Lollar (5-7) S: Brian Fisher (7) | Fifth | 15 out |
| Monday, August 19 |
| » Lost to Yankees (68-48), 6-5 | Yankee Stadium (2-5) | 57-59 | Lost 4 |
| » W: Marty Bystrom (2-1) L: Mark Clear (1-3) S: Rich Bordi (2) | Fifth | 15 out |
| Tuesday, August 20 |
| » Lost to Rangers (43-74), 3-1 | Fenway Park (32-26) | 57-60 | Lost 5 |
| » W: Charlie Hough (12-12) L: Bob Ojeda (5-8) | Fifth | 16 out |
| Wednesday, August 21 |
| » Lost to Rangers (44-74), 5-3 | Fenway Park (32-27) | 57-61 | Lost 6 |
| » W: Jeff Russell (1-3) L: Oil Can Boyd (11-11) S: Greg Harris (8) | Fifth | 16 out |
| Thursday, August 22 |
| » Defeated Rangers (44-75), 8-4 | Fenway Park (33-27) | 58-61 | |
| » W: Mike Trujillo (3-2) L: Dickie Noles (4-7) | Fifth | 15½ out |
| Friday, August 23 |
| » Lost to Twins (54-66), 5-2 | Fenway Park (33-28) | 58-62 | |
| » W: Frank Viola (13-10) L: Tim Lollar (5-8) | Fifth | 17 out |
| Saturday, August 24 |
| » Lost to Twins (55-66), 1-0 | Fenway Park (33-29) | 58-63 | Lost 2 |
| » W: Mike Smithson (12-11) L: Bruce Hurst (8-10) | Fifth | 18 out |
| Monday, August 26 |
| » Lost to White Sox (60-62), 7-6 | Comiskey Park I (2-4) | 58-64 | Lost 3 |
| » W: Bob James (6-5) L: Bob Stanley (6-6) | Fifth | 18½ out |
| Tuesday, August 27 |
| » Lost to Indians (45-80), 6-2 | Cleveland Stadium (1-3) | 58-65 | Lost 4 |
| » W: Curt Wardle (6-5) L: Mike Trujillo (3-3) S: Vern Ruhle (2) | Fifth | 19½ out |
| Wednesday, August 28 |
| » Lost to Indians (46-80), 7-4 | Cleveland Stadium (1-4) | 58-66 | Lost 5 |
| » W: Jamie Easterly (3-0) L: Tim Lollar (5-9) S: Jerry Reed (3) | Fifth | 19½ out |
| Thursday, August 29 |
| » Defeated Indians (46-81), 17-2 | Cleveland Stadium (2-4) | 59-66 | |
| » W: Bruce Hurst (9-10) L: Ramon Romero (2-3) | Fifth | 19 out |
| Friday, August 30 |
| » Defeated Twins (56-69), 7-3 | Hubert H. Humphrey Metrodome (3-1) | 60-66 | Won 2 |
| » W: Bob Ojeda (6-8) L: John Butcher (9-12) S: Steve Crawford (6) | Fifth | 19 out |
| Saturday, August 31 |
| » Lost to Twins (57-69), 6-5 | Hubert H. Humphrey Metrodome (3-2) | 60-67 | |
| » W: Bert Blyleven (13-13) L: Steve Crawford (5-4) | Fifth | 20½ out |
| » Lost to Twins (58-69), 5-4 | Hubert H. Humphrey Metrodome (3-3) | 60-68 | Lost 2 |
| » W: Mark Portugal (1-1) L: Al Nipper (7-10) S: Ron Davis (18) | Fifth | 20½ out |
| Sunday, September 1 |
| » Defeated Twins (58-70), 10-3 | Hubert H. Humphrey Metrodome (4-3) | 61-68 | |
| » W: Mike Trujillo (4-3) L: Frank Viola (13-12) | Fifth | 19½ out |
| Monday, September 2 |
| » Defeated Rangers (49-81), 11-2 | Arlington Stadium (1-4) | 62-68 | Won 2 |
| » W: Tim Lollar (6-9) L: Dave Stewart (0-6) | Fifth | 19½ out |
| Tuesday, September 3 |
| » Defeated Rangers (49-82), 6-4 | Arlington Stadium (2-4) | 63-68 | Won 3 |
| » W: Bruce Hurst (10-10) L: Charlie Hough (14-13) S: Bruce Kison (1) | Fifth | 19 out |
| Thursday, September 5 |
| » Defeated Indians (48-85), 13-6 | Fenway Park (34-29) | 64-68 | Won 4 |
| » W: Oil Can Boyd (12-11) L: Neal Heaton (8-15) | Fifth | 19 out |
| » Lost to Indians (49-85), 9-5 | Fenway Park (34-30) | 64-69 | |
| » W: Jamie Easterly (4-0) L: Bob Ojeda (6-9) S: Jerry Reed (4) | Fifth | 19 out |
| » Major-league debuts: Mike Greenwell, Kevin Romine and Rob Woodward (Red Sox) |
| Saturday, September 7 |
| » Defeated Indians (49-86), 11-9 | Fenway Park (35-30) | 65-69 | |
| » W: Bruce Kison (4-3) L: Jerry Reed (0-5) S: Steve Crawford (7) | Fifth | 18 out |
| » Defeated Indians (49-87), 7-4 | Fenway Park (36-30) | 66-69 | Won 2 |
| » W: Al Nipper (8-10) L: Curt Wardle (6-7) S: Steve Crawford (8) | Fifth | 18 out |
| Sunday, September 8 |
| » Defeated Indians (49-88), 8-1 | Fenway Park (37-30) | 67-69 | Won 3 |
| » W: Tim Lollar (7-9) L: Neal Heaton (8-16) | Fifth | 18 out |
| Tuesday, September 10 |
| » Lost to Orioles (72-62), 7-5 | Fenway Park (37-31) | 67-70 | |
| » W: Storm Davis (10-7) L: Bruce Hurst (10-11) S: Don Aase (9) | Fifth | 19 out |
| » Defeated Orioles (72-63), 5-3 | Fenway Park (38-31) | 68-70 | |
| » W: Oil Can Boyd (13-11) L: Mike Boddicker (12-15) S: Steve Crawford (9) | Fifth | 19 out |
| Wednesday, September 11 |
| » Defeated Orioles (72-64), 4-1 | Fenway Park (39-31) | 69-70 | Won 2 |
| » W: Bob Ojeda (7-9) L: Dennis Martinez (12-9) | Fifth | 19 out |
| Thursday, September 12 |
| » Lost to Orioles (73-64), 3-1 | Fenway Park (39-32) | 69-71 | |
| » W: Ken Dixon (7-3) L: Al Nipper (8-11) S: Don Aase (10) | Fifth | 19 out |
| Friday, September 13 |
| » Lost to Brewers (62-77), 6-3 | County Stadium (1-3) | 69-72 | Lost 2 |
| » W: Tim Leary (1-0) L: Tim Lollar (7-10) S: Danny Darwin (1) | Fifth | 20 out |
| Saturday, September 14 |
| » Defeated Brewers (62-78), 10-8 | County Stadium (2-3) | 70-72 | |
| » W: Bruce Kison (5-3) L: Danny Darwin (7-17) | Fifth | 20 out |
| » Major-league debuts: Bill Wegman (Brewers) |
| Sunday, September 15 |
| » Defeated Brewers (62-79), 4-2 | County Stadium (3-3) | 71-72 | Won 2 |
| » W: Jeff Sellers (1-0) L: Jaime Cocanower (4-6) S: Mike Trujillo (1) | Fifth | 20 out |
| » Major-league debuts: Jeff Sellers (Red Sox) |
| Monday, September 16 |
| » Lost to Brewers (63-79), 5-3 | County Stadium (3-4) | 71-73 | |
| » W: Bob McClure (4-1) L: Bob Ojeda (7-10) | Fifth | 20½ out |
| Tuesday, September 17 |
| » Defeated Blue Jays (91-53), 6-5 | Fenway Park (40-32) | 72-73 | |
| » W: Oil Can Boyd (14-11) L: Dave Stieb (13-11) S: Steve Crawford (10) | Fifth | 19½ out |
| Wednesday, September 18 |
| » Defeated Blue Jays (91-54), 13-1 | Fenway Park (41-32) | 73-73 | Won 2 |
| » W: Al Nipper (9-11) L: Jim Clancy (7-5) | Fifth | 18½ out |
| Friday, September 20 |
| » Lost to Tigers (77-70), 6-2 | Fenway Park (41-33) | 73-74 | |
| » W: Jack Morris (15-10) L: Bruce Hurst (10-12) | Fifth | 19½ out |
| Saturday, September 21 |
| » Defeated Tigers (77-71), 7-6 | Fenway Park (42-33) | 74-74 | |
| » W: Tim Lollar (8-10) L: Walt Terrell (13-10) S: Steve Crawford (11) | Fifth | 19½ out |
| Sunday, September 22 |
| » Defeated Tigers |