| Monday, April 8 |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Tuesday, April 9 |
| » Lost to Giants (1-0), 4-3 | Candlestick Park (0-1) | 0-1 | |
| » W: Vida Blue (1-0) L: Luis DeLeon (0-1) | Second | 1 out |
| Wednesday, April 10 |
| » Defeated Giants (1-1), 3-0 | Candlestick Park (1-1) | 1-1 | |
| » W: Eric Show (1-0) L: Dave LaPoint (0-1) | Second | ½ out |
| Friday, April 12 |
| » Defeated Braves (2-1), 7-3 | Atlanta-Fulton County Stadium (1-0) | 2-1 | Won 2 |
| » W: Andy Hawkins (1-0) L: Rick Camp (0-1) | First | -- |
| Saturday, April 13 |
| » Lost to Braves (3-1), 7-5 | Atlanta-Fulton County Stadium (1-1) | 2-2 | |
| » W: Bruce Sutter (1-0) L: Tim Stoddard (0-1) | Third | 1 out |
| Sunday, April 14 |
| » Lost to Braves (4-1), 3-1 | Atlanta-Fulton County Stadium (1-2) | 2-3 | Lost 2 |
| » W: Rick Mahler (2-0) L: La Marr Hoyt (0-1) S: Bruce Sutter (2) | Fourth | 2 out |
| Monday, April 15 |
| » Defeated Giants (3-3), 8-3 | San Diego/Jack Murphy Stadium (1-0) | 3-3 | |
| » W: Eric Show (2-0) L: Atlee Hammaker (0-1) | Third | 1 out |
| Tuesday, April 16 |
| » Defeated Giants (3-4), 2-1 | San Diego/Jack Murphy Stadium (2-0) | 4-3 | Won 2 |
| » W: Andy Hawkins (2-0) L: Dave LaPoint (0-2) S: Rich Gossage (1) | First | -- |
| Thursday, April 18 |
| » Lost to Dodgers (6-4), 5-0 | San Diego/Jack Murphy Stadium (2-1) | 4-4 | |
| » W: Fernando Valenzuela (2-1) L: Mark Thurmond (0-1) | Third | 1 out |
| Friday, April 19 |
| » Defeated Dodgers (6-5), 11-2 | San Diego/Jack Murphy Stadium (3-1) | 5-4 | |
| » W: La Marr Hoyt (1-1) L: Jerry Reuss (1-2) | Second | ½ out |
| Saturday, April 20 |
| » Defeated Dodgers (6-6), 4-3 | San Diego/Jack Murphy Stadium (4-1) | 6-4 | Won 2 |
| » W: Rich Gossage (1-0) L: Ken Howell (0-1) | Second | ½ out |
| Sunday, April 21 |
| » Lost to Dodgers (7-6), 2-0 | San Diego/Jack Murphy Stadium (4-2) | 6-5 | |
| » W: Orel Hershiser (2-0) L: Dave Dravecky (0-1) | Second | 1½ out |
| Monday, April 22 |
| » Defeated Braves (5-7), 5-3 | San Diego/Jack Murphy Stadium (5-2) | 7-5 | |
| » W: Andy Hawkins (3-0) L: Zane Smith (1-1) S: Rich Gossage (2) | Second | ½ out |
| Tuesday, April 23 |
| » Lost to Braves (6-7), 4-2 | San Diego/Jack Murphy Stadium (5-3) | 7-6 | |
| » W: Rick Mahler (4-0) L: Mark Thurmond (0-2) S: Bruce Sutter (3) | Second | ½ out |
| Wednesday, April 24 |
| » Defeated Braves (6-8), 3-1 | San Diego/Jack Murphy Stadium (6-3) | 8-6 | |
| » W: La Marr Hoyt (2-1) L: Pascual Perez (0-3) S: Rich Gossage (3) | Second | ½ out |
| Thursday, April 25 |
| » Lost to Dodgers (10-7), 6-3 | Dodger Stadium (0-1) | 8-7 | |
| » W: Rick Honeycutt (1-1) L: Eric Show (2-1) | Third | 1 out |
| Friday, April 26 |
| » Lost to Dodgers (11-7), 2-0 | Dodger Stadium (0-2) | 8-8 | Lost 2 |
| » W: Orel Hershiser (3-0) L: Dave Dravecky (0-2) | Third | 2 out |
| Saturday, April 27 |
| » Defeated Dodgers (11-8), 4-3 | Dodger Stadium (1-2) | 9-8 | |
| » W: Andy Hawkins (4-0) L: Tom Brennan (1-1) S: Rich Gossage (4) | Third | 1 out |
| Sunday, April 28 |
| » Defeated Dodgers (11-9), 1-0 | Dodger Stadium (2-2) | 10-8 | Won 2 |
| » W: Craig Lefferts (1-0) L: Fernando Valenzuela (2-3) S: Rich Gossage (5) | First | -- |
| Tuesday, April 30 |
| » Lost to Pirates (6-12), 6-2 | Three Rivers Stadium (0-1) | 10-9 | |
| » W: Rick Rhoden (1-3) L: La Marr Hoyt (2-2) S: Al Holland (2) | First | -- |
| Wednesday, May 1 |
| » Defeated Pirates (6-13), 6-4 | Three Rivers Stadium (1-1) | 11-9 | |
| » W: Eric Show (3-1) L: Jose DeLeon (0-4) S: Rich Gossage (6) | First | -- |
| Friday, May 3 |
| » Defeated Cubs (13-7), 6-5 | Wrigley Field (1-0) | 12-9 | Won 2 |
| » W: Andy Hawkins (5-0) L: Rick Sutcliffe (3-3) S: Rich Gossage (7) | First | -- |
| Saturday, May 4 |
| » Lost to Cubs (14-7), 12-8 | Wrigley Field (1-1) | 12-10 | |
| » W: Lary Sorensen (1-0) L: Greg Booker (0-1) S: Lee Smith (6) | First | -- |
| Monday, May 6 |
| » Lost to Cardinals (11-13), 5-2 | Busch Stadium II (0-1) | 12-11 | Lost 2 |
| » W: Danny Cox (2-1) L: Eric Show (3-2) S: Jeff Lahti (2) | Second | 1½ out |
| Tuesday, May 7 |
| » Defeated Cardinals (11-14), 12-2 | Busch Stadium II (1-1) | 13-11 | |
| » W: Dave Dravecky (1-2) L: Bob Forsch (2-2) | First | -- |
| Wednesday, May 8 |
| » Defeated Pirates (8-17), 12-2 | San Diego/Jack Murphy Stadium (7-3) | 14-11 | Won 2 |
| » W: Andy Hawkins (6-0) L: Larry McWilliams (3-2) | First | -- |
| Thursday, May 9 |
| » Defeated Pirates (8-18), 1-0 | San Diego/Jack Murphy Stadium (8-3) | 15-11 | Won 3 |
| » W: Mark Thurmond (1-2) L: Mike Bielecki (1-2) | First | -- |
| Friday, May 10 |
| » Lost to Cubs (17-9), 6-2 | San Diego/Jack Murphy Stadium (8-4) | 15-12 | |
| » W: Steve Trout (5-1) L: La Marr Hoyt (2-3) S: Lee Smith (8) | First | -- |
| Saturday, May 11 |
| » Defeated Cubs (17-10), 3-1 | San Diego/Jack Murphy Stadium (9-4) | 16-12 | |
| » W: Eric Show (4-2) L: Dennis Eckersley (4-2) S: Rich Gossage (8) | First | -- |
| Sunday, May 12 |
| » Defeated Cubs (17-11), 5-3 | San Diego/Jack Murphy Stadium (10-4) | 17-12 | Won 2 |
| » W: Dave Dravecky (2-2) L: Dick Ruthven (1-2) S: Rich Gossage (9) | First | -- |
| Tuesday, May 14 |
| » Defeated Cardinals (14-17), 6-2 | San Diego/Jack Murphy Stadium (11-4) | 18-12 | Won 3 |
| » W: Andy Hawkins (7-0) L: John Tudor (1-5) S: Mark Thurmond (1) | First | -- |
| Wednesday, May 15 |
| » Lost to Cardinals (15-17), 14-4 | San Diego/Jack Murphy Stadium (11-5) | 18-13 | |
| » W: Joaquin Andujar (6-1) L: La Marr Hoyt (2-4) | First | -- |
| Friday, May 17 |
| » Lost to Expos (20-14), 2-1 | Stade Olympique (0-1) | 18-14 | Lost 2 |
| » W: Jeff Reardon (2-1) L: Tim Stoddard (0-2) | First | -- |
| Saturday, May 18 |
| » Defeated Expos (20-15), 8-2 | Stade Olympique (1-1) | 19-14 | |
| » W: Dave Dravecky (3-2) L: Joe Hesketh (4-2) S: Rich Gossage (10) | First | -- |
| Sunday, May 19 |
| » Defeated Expos (20-16), 8-3 | Stade Olympique (2-1) | 20-14 | Won 2 |
| » W: Andy Hawkins (8-0) L: Steve Rogers (2-4) S: Luis DeLeon (1) | First | -- |
| Monday, May 20 |
| » Defeated Mets (23-12), 2-0 | Shea Stadium (1-0) | 21-14 | Won 3 |
| » W: La Marr Hoyt (3-4) L: Dwight Gooden (6-2) | First | -- |
| Wednesday, May 22 |
| » Defeated Mets (23-13), 5-4 | Shea Stadium (2-0) | 22-14 | Won 4 |
| » W: Mark Thurmond (2-2) L: Jesse Orosco (1-2) S: Rich Gossage (11) | First | -- |
| Friday, May 24 |
| » Defeated Phillies (15-24), 1-0 | Veteran's Stadium (1-0) | 23-14 | Won 5 |
| » W: Dave Dravecky (4-2) L: John Denny (1-5) S: Rich Gossage (12) | First | -- |
| Saturday, May 25 |
| » Defeated Phillies (15-25), 4-1 | Veteran's Stadium (2-0) | 24-14 | Won 6 |
| » W: Andy Hawkins (9-0) L: Charles Hudson (1-4) | First | -- |
| Sunday, May 26 |
| » Defeated Phillies (15-26), 7-2 | Veteran's Stadium (3-0) | 25-14 | Won 7 |
| » W: La Marr Hoyt (4-4) L: Steve Carlton (1-4) S: Rich Gossage (13) | First | -- |
| Monday, May 27 |
| » Lost to Phillies (16-26), 10-9 | Veteran's Stadium (3-1) | 25-15 | |
| » W: Kent Tekulve (3-1) L: Craig Lefferts (1-1) | First | -- |
| Tuesday, May 28 |
| » Lost to Expos (26-18), 8-5 | San Diego/Jack Murphy Stadium (11-6) | 25-16 | Lost 2 |
| » W: Bert Roberge (1-1) L: Rich Gossage (1-1) S: Jeff Reardon (13) | First | -- |
| Wednesday, May 29 |
| » Lost to Expos (27-18), 2-1 | San Diego/Jack Murphy Stadium (11-7) | 25-17 | Lost 3 |
| » W: Tim Burke (1-0) L: Craig Lefferts (1-2) S: Jeff Reardon (14) | First | -- |
| Thursday, May 30 |
| » Defeated Expos (27-19), 5-4 | San Diego/Jack Murphy Stadium (12-7) | 26-17 | |
| » W: Andy Hawkins (10-0) L: Dan Schatzeder (2-1) S: Craig Lefferts (1) | First | -- |
| Friday, May 31 |
| » Defeated Mets (27-16), 4-3 | San Diego/Jack Murphy Stadium (13-7) | 27-17 | Won 2 |
| » W: La Marr Hoyt (5-4) L: Doug Sisk (1-2) | First | -- |
| Saturday, June 1 |
| » Lost to Mets (28-16), 5-3 | San Diego/Jack Murphy Stadium (13-8) | 27-18 | |
| » W: Ron Darling (5-1) L: Mark Thurmond (2-3) S: Jesse Orosco (6) | First | -- |
| Sunday, June 2 |
| » Lost to Mets (29-16), 7-3 | San Diego/Jack Murphy Stadium (13-9) | 27-19 | Lost 2 |
| » W: Calvin Schiraldi (2-0) L: Eric Show (4-3) S: Doug Sisk (2) | First | -- |
| Monday, June 3 |
| » Lost to Phillies (18-30), 3-2 | San Diego/Jack Murphy Stadium (13-10) | 27-20 | Lost 3 |
| » W: Kevin Gross (4-6) L: Dave Dravecky (4-3) S: Kent Tekulve (3) | First | -- |
| Tuesday, June 4 |
| » Defeated Phillies (18-31), 6-5 | San Diego/Jack Murphy Stadium (14-10) | 28-20 | |
| » W: Craig Lefferts (2-2) L: Kent Tekulve (3-2) | First | -- |
| Wednesday, June 5 |
| » Defeated Phillies (18-32), 3-1 | San Diego/Jack Murphy Stadium (15-10) | 29-20 | Won 2 |
| » W: La Marr Hoyt (6-4) L: Charles Hudson (1-6) | First | -- |
| Friday, June 7 |
| » Defeated Reds (28-23), 9-3 | Riverfront Stadium (1-0) | 30-20 | Won 3 |
| » W: Mark Thurmond (3-3) L: Tom Browning (5-5) S: Luis DeLeon (2) | First | -- |
| » Defeated Reds (28-24), 3-2 | Riverfront Stadium (2-0) | 31-20 | Won 4 |
| » W: Craig Lefferts (3-2) L: Ted Power (0-2) | First | -- |
| Saturday, June 8 |
| » Lost to Reds (29-24), 7-4 | Riverfront Stadium (2-1) | 31-21 | |
| » W: Joe Price (2-0) L: Dave Dravecky (4-4) S: John Franco (2) | First | -- |
| Sunday, June 9 |
| » Defeated Reds (29-25), 5-3 | Riverfront Stadium (3-1) | 32-21 | |
| » W: Andy Hawkins (11-0) L: Mario Soto (8-4) | First | -- |
| Monday, June 10 |
| » Defeated Astros (29-26), 9-1 | Astrodome (1-0) | 33-21 | Won 2 |
| » W: La Marr Hoyt (7-4) L: Bob Knepper (6-2) | First | -- |
| Tuesday, June 11 |
| » Lost to Astros (30-26), 11-0 | Astrodome (1-1) | 33-22 | |
| » W: Mike Scott (5-2) L: Mark Thurmond (3-4) | First | -- |
| Wednesday, June 12 |
| » Lost to Astros (31-26), 3-2 | Astrodome (1-2) | 33-23 | Lost 2 |
| » W: Nolan Ryan (7-3) L: Eric Show (4-4) | First | -- |
| Thursday, June 13 |
| » Defeated Giants (21-36), 3-0 | Candlestick Park (2-1) | 34-23 | |
| » W: Dave Dravecky (5-4) L: Bill Laskey (1-7) S: Rich Gossage (14) | First | -- |
| Friday, June 14 |
| » Lost to Giants (22-36), 5-4 | Candlestick Park (2-2) | 34-24 | |
| » W: Mark Davis (3-3) L: Luis DeLeon (0-2) | First | -- |
| Saturday, June 15 |
| » Defeated Giants (22-37), 1-0 | Candlestick Park (3-2) | 35-24 | |
| » W: La Marr Hoyt (8-4) L: Jim Gott (3-4) | First | -- |
| Sunday, June 16 |
| » Lost to Giants (23-37), 7-3 | Candlestick Park (3-3) | 35-25 | |
| » W: Mike Krukow (5-4) L: Mark Thurmond (3-5) S: Mark Davis (3) | First | -- |
| » Lost to Giants (24-37), 5-4 | Candlestick Park (3-4) | 35-26 | Lost 2 |
| » W: Frank Williams (2-2) L: Mark Thurmond (3-6) | First | -- |
| Monday, June 17 |
| » Defeated Dodgers (31-29), 3-2 | Dodger Stadium (3-2) | 36-26 | |
| » W: Eric Show (5-4) L: Rick Honeycutt (4-6) S: Rich Gossage (15) | First | -- |
| Tuesday, June 18 |
| » Defeated Dodgers (31-30), 4-0 | Dodger Stadium (4-2) | 37-26 | Won 2 |
| » W: Dave Dravecky (6-4) L: Bob Welch (1-1) | First | -- |
| Wednesday, June 19 |
| » Lost to Dodgers (32-30), 5-1 | Dodger Stadium (4-3) | 37-27 | |
| » W: Jerry Reuss (5-5) L: Andy Hawkins (11-1) | First | -- |
| Thursday, June 20 |
| » Defeated Giants (26-39), 6-5 | San Diego/Jack Murphy Stadium (16-10) | 38-27 | |
| » W: La Marr Hoyt (9-4) L: Mark Davis (3-4) S: Rich Gossage (16) | First | -- |
| Friday, June 21 |
| » Defeated Giants (26-40), 6-1 | San Diego/Jack Murphy Stadium (17-10) | 39-27 | Won 2 |
| » W: Ed Wojna (1-0) L: Vida Blue (3-2) | First | -- |
| Saturday, June 22 |
| » Defeated Giants (26-41), 2-1 | San Diego/Jack Murphy Stadium (18-10) | 40-27 | Won 3 |
| » W: Eric Show (6-4) L: Bill Laskey (1-9) S: Tim Stoddard (1) | First | -- |
| Sunday, June 23 |
| » Defeated Giants (26-42), 6-1 | San Diego/Jack Murphy Stadium (19-10) | 41-27 | Won 4 |
| » W: Dave Dravecky (7-4) L: Atlee Hammaker (3-7) | First | -- |
| Tuesday, June 25 |
| » Lost to Dodgers (36-31), 3-2 | San Diego/Jack Murphy Stadium (19-11) | 41-28 | |
| » W: Ken Howell (3-3) L: Tim Stoddard (0-3) | First | -- |
| Wednesday, June 26 |
| » Defeated Dodgers (36-32), 10-4 | San Diego/Jack Murphy Stadium (20-11) | 42-28 | |
| » W: La Marr Hoyt (10-4) L: Orel Hershiser (7-2) | First | -- |
| Thursday, June 27 |
| » Defeated Dodgers (36-33), 5-4 | San Diego/Jack Murphy Stadium (21-11) | 43-28 | Won 2 |
| » W: Craig Lefferts (4-2) L: Fernando Valenzuela (7-8) S: Rich Gossage (17) | First | -- |
| Friday, June 28 |
| » Lost to Reds (38-32), 11-9 | San Diego/Jack Murphy Stadium (21-12) | 43-29 | |
| » W: Ron Robinson (3-0) L: Eric Show (6-5) S: Ted Power (13) | First | -- |
| Saturday, June 29 |
| » Defeated Reds (38-33), 3-0 | San Diego/Jack Murphy Stadium (22-12) | 44-29 | |
| » W: Dave Dravecky (8-4) L: Mario Soto (8-7) | First | -- |
| Sunday, June 30 |
| » Lost to Reds (39-33), 3-2 | San Diego/Jack Murphy Stadium (22-13) | 44-30 | |
| » W: John Franco (4-1) L: Andy Hawkins (11-2) | First | -- |
| Monday, July 1 |
| » Defeated Astros (38-38), 6-5 | San Diego/Jack Murphy Stadium (23-13) | 45-30 | |
| » W: Rich Gossage (2-1) L: Nolan Ryan (8-6) | First | -- |
| Tuesday, July 2 |
| » Lost to Astros (39-38), 3-2 | San Diego/Jack Murphy Stadium (23-14) | 45-31 | |
| » W: Joe Niekro (7-7) L: Ed Wojna (1-1) S: Jeff Calhoun (3) | First | -- |
| Thursday, July 4 |
| » Defeated Pirates (25-50), 9-1 | Three Rivers Stadium (2-1) | 46-31 | |
| » W: Eric Show (7-5) L: Rick Rhoden (5-8) | First | -- |
| Friday, July 5 |
| » Lost to Pirates (26-50), 5-4 | Three Rivers Stadium (2-2) | 46-32 | |
| » W: Rick Reuschel (7-1) L: Craig Lefferts (4-3) | First | -- |
| Saturday, July 6 |
| » Lost to Pirates (27-50), 8-7 | Three Rivers Stadium (2-3) | 46-33 | Lost 2 |
| » W: John Candelaria (2-3) L: Craig Lefferts (4-4) | First | -- |
| Sunday, July 7 |
| » Defeated Pirates (27-51), 3-0 | Three Rivers Stadium (3-3) | 47-33 | |
| » W: La Marr Hoyt (11-4) L: Rick Reuschel (7-2) | First | -- |
| Monday, July 8 |
| » Defeated Cubs (41-38), 8-4 | Wrigley Field (2-1) | 48-33 | Won 2 |
| » W: Tim Stoddard (1-3) L: Lary Sorensen (1-2) | First | -- |
| » Lost to Cubs (42-38), 6-3 | Wrigley Field (2-2) | 48-34 | |
| » W: George Frazier (4-2) L: Luis DeLeon (0-3) | First | -- |
| Tuesday, July 9 |
| » Lost to Cubs (43-38), 7-3 | Wrigley Field (2-3) | 48-35 | Lost 2 |
| » W: Steve Trout (8-4) L: Eric Show (7-6) S: George Frazier (2) | First | -- |
| Wednesday, July 10 |
| » Lost to Cubs (44-38), 4-3 | Wrigley Field (2-4) | 48-36 | Lost 3 |
| » W: Scott Sanderson (5-4) L: Dave Dravecky (8-5) S: Lee Smith (19) | First | -- |
| Thursday, July 11 |
| » Lost to Cardinals (50-32), 6-0 | Busch Stadium II (1-2) | 48-37 | Lost 4 |
| » W: John Tudor (10-7) L: Mark Thurmond (3-7) | First | -- |
| Friday, July 12 |
| » Defeated Cardinals (50-33), 2-0 | Busch Stadium II (2-2) | 49-37 | |
| » W: La Marr Hoyt (12-4) L: Joaquin Andujar (15-4) S: Rich Gossage (18) | First | -- |
| Saturday, July 13 |
| » Lost to Cardinals (51-33), 7-3 | Busch Stadium II (2-3) | 49-38 | |
| » W: Danny Cox (11-4) L: Ed Wojna (1-2) S: Jeff Lahti (8) | Second | 1½ out |
| Sunday, July 14 |
| » Lost to Cardinals (52-33), 2-1 | Busch Stadium II (2-4) | 49-39 | Lost 2 |
| » W: Kurt Kepshire (7-6) L: Dave Dravecky (8-6) S: Jeff Lahti (9) | Second | 1½ out |
| Thursday, July 18 |
| » Defeated Pirates (29-57), 3-2 | San Diego/Jack Murphy Stadium (24-14) | 50-39 | |
| » W: Craig Lefferts (5-4) L: John Candelaria (2-4) S: Rich Gossage (19) | Second | 1½ out |
| Friday, July 19 |
| » Defeated Pirates (29-58), 6-0 | San Diego/Jack Murphy Stadium (25-14) | 51-39 | Won 2 |
| » W: Andy Hawkins (12-2) L: Jose DeLeon (2-14) | Second | 1½ out |
| Saturday, July 20 |
| » Defeated Pirates (29-59), 4-2 | San Diego/Jack Murphy Stadium (26-14) | 52-39 | Won 3 |
| » W: La Marr Hoyt (13-4) L: Rick Rhoden (5-11) S: Rich Gossage (20) | Second | 1½ out |
| Sunday, July 21 |
| » Lost to Pirates (30-59), 5-2 | San Diego/Jack Murphy Stadium (26-15) | 52-40 | |
| » W: Lee Tunnell (1-6) L: Eric Show (7-7) | Second | 1½ out |
| Monday, July 22 |
| » Lost to Cubs (48-43), 5-3 | San Diego/Jack Murphy Stadium (26-16) | 52-41 | Lost 2 |
| » W: Ron Meridith (1-0) L: Roy Lee Jackson (0-1) S: Lee Smith (22) | Second | 1½ out |
| Tuesday, July 23 |
| » Lost to Cubs (49-43), 8-1 | San Diego/Jack Murphy Stadium (26-17) | 52-42 | Lost 3 |
| » W: Rick Sutcliffe (8-7) L: Andy Hawkins (12-3) | Second | 1½ out |
| Wednesday, July 24 |
| » Lost to Cubs (50-43), 4-3 | San Diego/Jack Murphy Stadium (26-18) | 52-43 | Lost 4 |
| » W: Lee Smith (5-4) L: Tim Stoddard (1-4) S: George Frazier (3) | Second | 2½ out |
| Thursday, July 25 |
| » Lost to Cardinals (57-36), 9-6 | San Diego/Jack Murphy Stadium (26-19) | 52-44 | Lost 5 |
| » W: Ken Dayley (3-0) L: Rich Gossage (2-2) S: Jeff Lahti (11) | Second | 3½ out |
| Friday, July 26 |
| » Lost to Cardinals (58-36), 2-1 | San Diego/Jack Murphy Stadium (26-20) | 52-45 | Lost 6 |
| » W: Joaquin Andujar (17-4) L: Tim Stoddard (1-5) S: Ken Dayley (7) | Second | 4½ out |
| Saturday, July 27 |
| » Defeated Cardinals (58-37), 2-0 | San Diego/Jack Murphy Stadium (27-20) | 53-45 | |
| » W: Andy Hawkins (13-3) L: Danny Cox (12-6) S: Rich Gossage (21) | Second | 4½ out |
| Sunday, July 28 |
| » Lost to Cardinals (59-37), 4-2 | San Diego/Jack Murphy Stadium (27-21) | 53-46 | |
| » W: John Tudor (12-8) L: La Marr Hoyt (13-5) S: Jeff Lahti (12) | Second | 4½ out |
| Tuesday, July 30 |
| » Defeated Braves (43-55), 5-4 | Atlanta-Fulton County Stadium (2-2) | 54-46 | |
| » W: Craig Lefferts (6-4) L: Rick Camp (2-5) S: Roy Lee Jackson (1) | Second | 5 out |
| Wednesday, July 31 |
| » Lost to Braves (44-55), 5-4 | Atlanta-Fulton County Stadium (2-3) | 54-47 | |
| » W: Bruce Sutter (7-4) L: Tim Stoddard (1-6) | Second | 5 out |
| Thursday, August 1 |
| » Defeated Braves (44-56), 6-0 | Atlanta-Fulton County Stadium (3-3) | 55-47 | |
| » W: Andy Hawkins (14-3) L: Zane Smith (6-8) | Second | 4½ out |
| Friday, August 2 |
| » Lost to Astros (47-56), 12-9 | Astrodome (1-3) | 55-48 | |
| » W: Joe Niekro (9-8) L: La Marr Hoyt (13-6) S: Dave Smith (16) | Third | 5 out |
| Saturday, August 3 |
| » Lost to Astros (48-56), 4-3 | Astrodome (1-4) | 55-49 | Lost 2 |
| » W: Charlie Kerfeld (1-1) L: Craig Lefferts (6-5) | Second | 6 out |
| Sunday, August 4 |
| » Lost to Astros (49-56), 2-1 | Astrodome (1-5) | 55-50 | Lost 3 |
| » W: Mike Scott (11-5) L: Dave Dravecky (8-7) S: Dave Smith (17) | Third | 6 out |
| Monday, August 5 |
| » Lost to Reds (56-48), 8-7 | Riverfront Stadium (3-2) | 55-51 | Lost 4 |
| » W: Tom Hume (2-3) L: Roy Lee Jackson (0-2) S: Ted Power (19) | Third | 7 out |
| Thursday, August 8 |
| » Defeated Astros (50-57), 6-5 | San Diego/Jack Murphy Stadium (28-21) | 56-51 | |
| » W: Craig Lefferts (7-5) L: Dave Smith (5-4) | Third | 6 out |
| Friday, August 9 |
| » Defeated Astros (50-58), 6-4 | San Diego/Jack Murphy Stadium (29-21) | 57-51 | Won 2 |
| » W: Dave Dravecky (9-7) L: Nolan Ryan (8-10) S: Gene Walter (1) | Third | 5½ out |
| » Defeated Astros (50-59), 2-1 | San Diego/Jack Murphy Stadium (30-21) | 58-51 | Won 3 |
| » W: Eric Show (8-7) L: Mike Scott (11-6) S: Mark Thurmond (2) | Third | 5½ out |
| » Major-league debuts: Gene Walter (Padres) |
| Sunday, August 11 |
| » Lost to Astros (51-59), 7-2 | San Diego/Jack Murphy Stadium (30-22) | 58-52 | |
| » W: Bob Knepper (10-9) L: Andy Hawkins (14-4) | Third | 7 out |
| Monday, August 12 |
| » Defeated Reds (57-52), 2-0 | San Diego/Jack Murphy Stadium (31-22) | 59-52 | |
| » W: Mark Thurmond (4-7) L: Mario Soto (10-13) S: Lance McCullers (1) | Second | 7 out |
| » Major-league debuts: Lance McCullers (Padres) |
| Tuesday, August 13 |
| » Lost to Reds (58-52), 3-2 | San Diego/Jack Murphy Stadium (31-23) | 59-53 | |
| » W: Tom Browning (10-9) L: La Marr Hoyt (13-7) S: John Franco (4) | Second | 8 out |
| Wednesday, August 14 |
| » Defeated Reds (58-53), 4-1 | San Diego/Jack Murphy Stadium (32-23) | 60-53 | |
| » W: Dave Dravecky (10-7) L: Jay Tibbs (5-13) | Second | 8 out |
| Thursday, August 15 |
| » Lost to Reds (59-53), 5-4 | San Diego/Jack Murphy Stadium (32-24) | 60-54 | |
| » W: John Franco (10-1) L: Gene Walter (0-1) S: Joe Price (1) | Third | 9 out |
| Friday, August 16 |
| » Defeated Braves (49-64), 6-3 | San Diego/Jack Murphy Stadium (33-24) | 61-54 | |
| » W: Andy Hawkins (15-4) L: Rick Mahler (16-11) S: Lance McCullers (2) | Second | 9 out |
| Sunday, August 18 |
| » Defeated Braves (49-65), 2-1 | San Diego/Jack Murphy Stadium (34-24) | 62-54 | Won 2 |
| » W: Roy Lee Jackson (1-2) L: Steve Bedrosian (5-11) S: Lance McCullers (3) | Second | 8 out |
| » Lost to Braves (50-65), 6-3 | San Diego/Jack Murphy Stadium (34-25) | 62-55 | |
| » W: Terry Forster (2-3) L: La Marr Hoyt (13-8) S: Bruce Sutter (20) | Second | 8 out |
| Tuesday, August 20 |
| » Defeated Expos (67-52), 1-0 | Stade Olympique (3-1) | 63-55 | |
| » W: Dave Dravecky (11-7) L: Bill Gullickson (11-9) S: Gene Walter (2) | Second | 8 out |
| Wednesday, August 21 |
| » Defeated Expos (67-53), 6-2 | Stade Olympique (4-1) | 64-55 | Won 2 |
| » W: Eric Show (9-7) L: Bill Laskey (5-13) | Second | 8 out |
| Thursday, August 22 |
| » Defeated Expos (67-54), 3-0 | Stade Olympique (5-1) | 65-55 | Won 3 |
| » W: Andy Hawkins (16-4) L: Floyd Youmans (1-1) | Second | 7 out |
| Friday, August 23 |
| » Defeated Mets (73-47), 6-1 | Shea Stadium (3-0) | 66-55 | Won 4 |
| » W: Mark Thurmond (5-7) L: Rick Aguilera (6-5) S: Craig Lefferts (2) | Second | 6½ out |
| » Defeated Mets (73-48), 3-0 | Shea Stadium (4-0) | 67-55 | Won 5 |
| » W: Roy Lee Jackson (2-2) L: Sid Fernandez (5-7) S: Lance McCullers (4) | Second | 6½ out |
| Saturday, August 24 |
| » Lost to Mets (74-48), 5-1 | Shea Stadium (4-1) | 67-56 | |
| » W: Ron Darling (12-5) L: Dave Dravecky (11-8) S: Jesse Orosco (14) | Second | 6½ out |
| Sunday, August 25 |
| » Lost to Mets (75-48), 9-3 | Shea Stadium (4-2) | 67-57 | Lost 2 |
| » W: Dwight Gooden (20-3) L: Eric Show (9-8) S: Roger McDowell (12) | Second | 6½ out |
| Monday, August 26 |
| » Lost to Phillies (58-65), 4-3 | Veteran's Stadium (3-2) | 67-58 | Lost 3 |
| » W: Don Carman (5-4) L: Lance McCullers (0-1) | Second | 7½ out |
| Tuesday, August 27 |
| » Defeated Phillies (58-66), 4-1 | Veteran's Stadium (4-2) | 68-58 | |
| » W: Mark Thurmond (6-7) L: John Denny (8-11) S: Roy Lee Jackson (2) | Second | 7½ out |
| Thursday, August 29 |
| » Lost to Expos (70-57), 8-5 | San Diego/Jack Murphy Stadium (34-26) | 68-59 | |
| » W: Bert Roberge (3-1) L: Gene Walter (0-2) S: Jeff Reardon (33) | Second | 7½ out |
| Saturday, August 31 |
| » Lost to Expos (71-57), 7-1 | San Diego/Jack Murphy Stadium (34-27) | 68-60 | Lost 2 |
| » W: Bill Gullickson (13-9) L: Eric Show (9-9) | Second | 7 out |
| Sunday, September 1 |
| » Defeated Expos (71-58), 5-1 | San Diego/Jack Murphy Stadium (35-27) | 69-60 | |
| » W: Andy Hawkins (17-4) L: Floyd Youmans (1-2) S: Lance McCullers (5) | Second | 6 out |
| Monday, September 2 |
| » Lost to Mets (78-52), 12-4 | San Diego/Jack Murphy Stadium (35-28) | 69-61 | |
| » W: Sid Fernandez (6-8) L: Mark Thurmond (6-8) | Third | 7 out |
| » Major-league debuts: Bob Patterson (Padres) |
| Tuesday, September 3 |
| » Lost to Mets (79-52), 8-3 | San Diego/Jack Murphy Stadium (35-29) | 69-62 | Lost 2 |
| » W: Rick Aguilera (7-5) L: Dave Dravecky (11-9) | Third | 8 out |
| Wednesday, September 4 |
| » Lost to Mets (80-52), 9-2 | San Diego/Jack Murphy Stadium (35-30) | 69-63 | Lost 3 |
| » W: Ron Darling (14-5) L: Roy Lee Jackson (2-3) | Third | 9 out |
| Friday, September 6 |
| » Defeated Phillies (64-68), 3-2 | San Diego/Jack Murphy Stadium (36-30) | 70-63 | |
| » W: Rich Gossage (3-2) L: Dave Shipanoff (1-1) | Third | 8 out |
| Saturday, September 7 |
| » Lost to Phillies (65-68), 2-0 | San Diego/Jack Murphy Stadium (36-31) | 70-64 | |
| » W: John Denny (10-11) L: Andy Hawkins (17-5) | Third | 9 out |
| Sunday, September 8 |
| » Lost to Phillies (66-68), 9-7 | San Diego/Jack Murphy Stadium (36-32) | 70-65 | Lost 2 |
| » W: Rick Surhoff (1-0) L: Ed Wojna (1-3) S: Dave Rucker (1) | Third | 9 out |
| Monday, September 9 |
| » Lost to Reds (71-63), 2-1 | Riverfront Stadium (3-3) | 70-66 | Lost 3 |
| » W: John Franco (12-2) L: Rich Gossage (3-3) | Third | 10 out |
| Tuesday, September 10 |
| » Defeated Reds (71-64), 3-2 | Riverfront Stadium (4-3) | 71-66 | |
| » W: La Marr Hoyt (14-8) L: Ron Robinson (5-5) S: Rich Gossage (22) | Third | 10½ out |
| Wednesday, September 11 |
| » Lost to Reds (72-64), 2-0 | Riverfront Stadium (4-4) | 71-67 | |
| » W: Tom Browning (16-9) L: Eric Show (9-10) S: Ted Power (20) | Third | 11½ out |
| Thursday, September 12 |
| » Lost to Reds (73-64), 2-1 | Riverfront Stadium (4-5) | 71-68 | Lost 2 |
| » W: Jay Tibbs (8-15) L: Andy Hawkins (17-6) S: Ted Power (21) | Third | 11½ out |
| Friday, September 13 |
| » Lost to Astros (70-70), 3-2 | Astrodome (1-6) | 71-69 | Lost 3 |
| » W: Mike Scott (17-7) L: Mark Thurmond (6-9) | Third | 12 out |
| Saturday, September 14 |
| » Lost to Astros (71-70), 4-3 | Astrodome (1-7) | 71-70 | Lost 4 |
| » W: Bob Knepper (14-10) L: Dave Dravecky (11-10) S: Dave Smith (23) | Third | 13 out |
| Sunday, September 15 |
| » Lost to Astros (72-70), 2-1 | Astrodome (1-8) | 71-71 | Lost 5 |
| » W: Jeff Calhoun (2-3) L: Craig Lefferts (7-6) S: Dave Smith (24) | Fourth | 13 out |
| Monday, September 16 |
| » Defeated Dodgers (84-59), 4-2 | San Diego/Jack Murphy Stadium (37-32) | 72-71 | |
| » W: Eric Show (10-10) L: Jerry Reuss (12-10) S: Rich Gossage (23) | Fourth | 12 out |
| Tuesday, September 17 |
| » Lost to Dodgers (85-59), 7-1 | San Diego/Jack Murphy Stadium (37-33) | 72-72 | |
| » W: Orel Hershiser (16-3) L: Andy Hawkins (17-7) | Fourth | 13 out |
| Wednesday, September 18 |
| » Lost to Giants (57-88), 9-6 | Candlestick Park (3-5) | 72-73 | Lost 2 |
| » W: Vida Blue (7-6) L: Mark Thurmond (6-10) S: Scott Garrelts (13) | Fourth | 13 out |
| Thursday, September 19 |
| » Defeated Giants (57-89), 11-3 | Candlestick Park (4-5) | 73-73 | |
| » W: Dave Dravecky (12-10) L: Atlee Hammaker (4-12) | Fourth | 12 out |
| Friday, September 20 |
| » Defeated Braves (60-87), 11-1 | San Diego/Jack Murphy Stadium (38-33) | 74-73 | Won 2 |
| » W: La Marr Hoyt (15-8) L: Steve Bedrosian (7-13) S: Gene Walter (3) | Fourth | 11 out |
| Saturday, September 21 |
| » Defeated Braves (60-88), 1-0 | San Diego/Jack Murphy Stadium (39-33) | 75-73 | Won 3 |
| » W: Eric Show (11-10) L: Joe Johnson (4-2) | Fourth | 11 out |
| Sunday, September 22 |
| » Lost to Braves (61-88), 7-5 | San Diego/Jack Murphy Stadium (39-34) | 75-74 | |
| » W: Zane Smith (8-10) L: Andy Hawkins (17-8) | Fourth | 12 out |
| Monday, September 23 |
| » Lost to Giants (59-91), 7-2 | San Diego/Jack Murphy Stadium (39-35) | 75-75 | Lost 2 |
| » W: Atlee Hammaker (5-12) L: Mark Thurmond (6-11) | Fourth | 13 out |
| Tuesday, September 24 |
| » Defeated Giants (59-92), 4-3 | San Diego/Jack Murphy Stadium (40-35) | 76-75 | |
| » W: Dave Dravecky (13-10) L: Dave LaPoint (7-15) S: Rich Gossage (24) | Fourth | 13 out |
| Wednesday, September 25 |
| » Defeated Giants (59-93), 7-4 | San Diego/Jack Murphy Stadium (41-35) | 77-75 | Won 2 |
| » W: La Marr Hoyt (16-8) L: Roger Mason (0-2) S: Rich Gossage (25) | Fourth | 12 out |
| Friday, September 27 |
| » Defeated Braves (62-91), 10-1 | Atlanta-Fulton County Stadium (4-3) | 78-75 | Won 3 |
| » W: Eric Show (12-10) L: Joe Johnson (4-3) | Third | 12 out |
| Saturday, September 28 |
| » Defeated Braves (62-92), 6-5 | Atlanta-Fulton County Stadium (5-3) | 79-75 | Won 4 |
| » W: Ed Wojna (2-3) L: Jeff Dedmon (5-3) S: Luis DeLeon (3) | Third | 12 out |
| Sunday, September 29 |
| » Lost to Braves (63-92), 3-2 | Atlanta-Fulton County Stadium (5-4) | 79-76 | |
| » W: Rick Camp (3-6) L: Lance McCullers (0-2) | Third | 13 out |
| Monday, September 30 |
| » Defeated Dodgers (92-64) |