| Sunday, March 10 |
| Former Oriole Bob Nieman dies in Corona, CA at the age of 59. |
| Monday, April 8 |
| » Defeated Rangers (0-1), 4-2 | Memorial Stadium (1-0) | 1-0 | |
| » W: Don Aase (1-0) L: Dave Rozema (0-1) | First | -- |
| Wednesday, April 10 |
| » Defeated Rangers (0-2), 7-1 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » W: Mike Boddicker (1-0) L: Mike Mason (0-1) S: Sammy Stewart (1) | First | -- |
| Friday, April 12 |
| » Defeated Blue Jays (2-2), 7-2 | Memorial Stadium (3-0) | 3-0 | Won 3 |
| » W: Scott McGregor (1-0) L: Jimmy Key (0-1) S: Sammy Stewart (2) | First | -- |
| Saturday, April 13 |
| » Defeated Blue Jays (2-3), 8-7 | Memorial Stadium (4-0) | 4-0 | Won 4 |
| » W: Tippy Martinez (1-0) L: Bill Caudill (2-1) | First | -- |
| Sunday, April 14 |
| » Lost to Blue Jays (3-3), 5-3 | Memorial Stadium (4-1) | 4-1 | |
| » W: Doyle Alexander (1-0) L: Mike Boddicker (1-1) S: Jim Acker (2) | Second | 1 out |
| Tuesday, April 16 |
| » Lost to Indians (1-5), 6-3 | Cleveland Stadium (0-1) | 4-2 | Lost 2 |
| » W: Vern Ruhle (1-1) L: Dennis Martinez (0-1) S: Tom Waddell (1) | Second | 2 out |
| Wednesday, April 17 |
| » Defeated Indians (1-6), 6-3 | Cleveland Stadium (1-1) | 5-2 | |
| » W: Sammy Stewart (1-0) L: Jose Roman (0-1) | Second | 1 out |
| Thursday, April 18 |
| » Lost to Indians (2-6), 11-5 | Cleveland Stadium (1-2) | 5-3 | |
| » W: Dave VonOhlen (1-1) L: Nate Snell (0-1) | Third | 1½ out |
| Friday, April 19 |
| » Lost to Blue Jays (6-4), 6-5 | Exhibition Stadium (0-1) | 5-4 | Lost 2 |
| » W: Doyle Alexander (2-0) L: Sammy Stewart (1-1) S: Bill Caudill (2) | Fourth | 1½ out |
| Saturday, April 20 |
| » Lost to Blue Jays (7-4), 3-2 | Exhibition Stadium (0-2) | 5-5 | Lost 3 |
| » W: Ron Musselman (1-0) L: Tippy Martinez (1-1) S: Gary Lavelle (2) | Fifth | 2½ out |
| Sunday, April 21 |
| » Defeated Blue Jays (7-5), 3-2 | Exhibition Stadium (1-2) | 6-5 | |
| » W: Dennis Martinez (1-1) L: Jimmy Key (0-2) S: Tippy Martinez (1) | Third | 1½ out |
| Monday, April 22 |
| » Lost to Rangers (5-7), 6-1 | Arlington Stadium (0-1) | 6-6 | |
| » W: Charlie Hough (1-0) L: Scott McGregor (1-1) | Fifth | 1½ out |
| Tuesday, April 23 |
| » Defeated Rangers (5-8), 11-1 | Arlington Stadium (1-1) | 7-6 | |
| » W: Storm Davis (1-0) L: Frank Tanana (0-3) | Second | 1½ out |
| Wednesday, April 24 |
| » Defeated Rangers (5-9), 2-1 | Arlington Stadium (2-1) | 8-6 | Won 2 |
| » W: Mike Boddicker (2-1) L: Dave Rozema (1-3) S: Tippy Martinez (2) | Second | ½ out |
| Thursday, April 25 |
| » Defeated Indians (6-9), 7-1 | Memorial Stadium (5-1) | 9-6 | Won 3 |
| » W: Ken Dixon (1-0) L: Jose Roman (0-3) | First | -- |
| Friday, April 26 |
| » Defeated Indians (6-10), 6-3 | Memorial Stadium (6-1) | 10-6 | Won 4 |
| » W: Dennis Martinez (2-1) L: Vern Ruhle (1-2) S: Sammy Stewart (3) | First | -- |
| Saturday, April 27 |
| » Lost to Indians (7-10), 10-4 | Memorial Stadium (6-2) | 10-7 | |
| » W: Don Schulze (2-0) L: Scott McGregor (1-2) | Second | ½ out |
| Sunday, April 28 |
| » Defeated Indians (7-11), 8-7 | Memorial Stadium (7-2) | 11-7 | |
| » W: Don Aase (2-0) L: Tom Waddell (0-2) | Second | ½ out |
| Tuesday, April 30 |
| » Defeated White Sox (9-8), 9-7 | Memorial Stadium (8-2) | 12-7 | Won 2 |
| » W: Mike Boddicker (3-1) L: Floyd Bannister (0-3) S: Sammy Stewart (4) | Second | ½ out |
| Wednesday, May 1 |
| » Defeated White Sox (9-9), 3-1 | Memorial Stadium (9-2) | 13-7 | Won 3 |
| » W: Ken Dixon (2-0) L: Britt Burns (3-2) S: Don Aase (1) | Second | ½ out |
| Friday, May 3 |
| » Defeated Twins (12-10), 8-7 | Hubert H. Humphrey Metrodome (1-0) | 14-7 | Won 4 |
| » W: Don Aase (3-0) L: Curt Wardle (0-1) | First | -- |
| Saturday, May 4 |
| » Lost to Twins (13-10), 8-6 | Hubert H. Humphrey Metrodome (1-1) | 14-8 | |
| » W: Ken Schrom (2-2) L: Dennis Martinez (2-2) S: Ron Davis (4) | First | -- |
| Sunday, May 5 |
| » Defeated Twins (13-11), 10-5 | Hubert H. Humphrey Metrodome (2-1) | 15-8 | |
| » W: Mike Boddicker (4-1) L: John Butcher (3-2) | First | -- |
| Tuesday, May 7 |
| » Defeated Royals (11-13), 4-2 | Royals Stadium (1-0) | 16-8 | Won 2 |
| » W: Ken Dixon (3-0) L: Bret Saberhagen (2-3) S: Sammy Stewart (5) | First | -- |
| Wednesday, May 8 |
| » Lost to Royals (12-13), 9-8 | Royals Stadium (1-1) | 16-9 | |
| » W: Mike LaCoss (1-0) L: Scott McGregor (1-3) | First | -- |
| Friday, May 10 |
| » Defeated Twins (15-12), 6-5 | Memorial Stadium (10-2) | 17-9 | |
| » W: Don Aase (4-0) L: Ron Davis (1-2) | First | -- |
| Saturday, May 11 |
| » Defeated Twins (15-13), 4-2 | Memorial Stadium (11-2) | 18-9 | Won 2 |
| » W: Mike Boddicker (5-1) L: Ron Davis (1-3) | First | -- |
| Sunday, May 12 |
| » Lost to Twins (16-13), 7-3 | Memorial Stadium (11-3) | 18-10 | |
| » W: Frank Viola (6-2) L: Ken Dixon (3-1) | First | -- |
| Monday, May 13 |
| » Lost to Royals (14-15), 5-2 | Memorial Stadium (11-4) | 18-11 | Lost 2 |
| » W: Danny Jackson (2-1) L: Storm Davis (1-1) S: Dan Quisenberry (4) | Second | ½ out |
| Tuesday, May 14 |
| » Lost to Royals (15-15), 5-3 | Memorial Stadium (11-5) | 18-12 | Lost 3 |
| » W: Mark Gubicza (1-2) L: Scott McGregor (1-4) S: Dan Quisenberry (5) | Third | 1½ out |
| Former Oriole Harry Byrd dies in Darlington, SC at the age of 61. |
| Wednesday, May 15 |
| » Lost to White Sox (17-12), 5-2 | Comiskey Park I (0-1) | 18-13 | Lost 4 |
| » W: Tom Seaver (4-1) L: Don Aase (4-1) S: Bob James (6) | Third | 1½ out |
| Thursday, May 16 |
| » Defeated White Sox (17-13), 3-1 | Comiskey Park I (1-1) | 19-13 | |
| » W: Mike Boddicker (6-1) L: Floyd Bannister (2-4) | Second | 1 out |
| Friday, May 17 |
| » Defeated Mariners (15-19), 11-3 | Kingdome (1-0) | 20-13 | Won 2 |
| » W: Ken Dixon (4-1) L: Matt Young (2-5) S: Nate Snell (1) | First | -- |
| Saturday, May 18 |
| » Lost to Mariners (16-19), 8-7 | Kingdome (1-1) | 20-14 | |
| » W: Edwin Nunez (2-0) L: Tippy Martinez (1-2) | Third | 1 out |
| Sunday, May 19 |
| » Defeated Mariners (16-20), 2-1 | Kingdome (2-1) | 21-14 | |
| » W: Dennis Martinez (3-2) L: Mike Moore (4-4) | First | -- |
| Tuesday, May 21 |
| » Lost to Athletics (18-19), 3-2 | Oakland-Alameda County Stadium (0-1) | 21-15 | |
| » W: Jay Howell (1-2) L: Mike Boddicker (6-2) | Second | 1½ out |
| Wednesday, May 22 |
| » Defeated Athletics (18-20), 3-0 | Oakland-Alameda County Stadium (1-1) | 22-15 | |
| » W: Scott McGregor (2-4) L: Don Sutton (3-5) | Second | 1½ out |
| Thursday, May 23 |
| » Lost to Athletics (19-20), 4-2 | Oakland-Alameda County Stadium (1-2) | 22-16 | |
| » W: Tim Birtsas (1-0) L: Ken Dixon (4-2) S: Jay Howell (10) | Second | 2½ out |
| Friday, May 24 |
| » Defeated Angels (23-17), 4-3 | Anaheim Stadium (1-0) | 23-16 | |
| » W: Storm Davis (2-1) L: Stew Cliburn (1-1) | Second | 2½ out |
| Saturday, May 25 |
| » Lost to Angels (24-17), 5-3 | Anaheim Stadium (1-1) | 23-17 | |
| » W: Ron Romanick (6-1) L: Dennis Martinez (3-3) S: Donnie Moore (10) | Third | 3½ out |
| Sunday, May 26 |
| » Lost to Angels (25-17), 10-4 | Anaheim Stadium (1-2) | 23-18 | Lost 2 |
| » W: Pat Clements (3-0) L: Mike Boddicker (6-3) | Third | 4½ out |
| Monday, May 27 |
| » Defeated Angels (25-18), 6-4 | Anaheim Stadium (2-2) | 24-18 | |
| » W: Scott McGregor (3-4) L: Tommy John (2-4) | Third | 4 out |
| Wednesday, May 29 |
| » Lost to Mariners (20-24), 5-4 | Memorial Stadium (11-6) | 24-19 | |
| » W: Karl Best (1-1) L: Don Aase (4-2) | Third | 4½ out |
| Thursday, May 30 |
| » Defeated Mariners (20-25), 8-2 | Memorial Stadium (12-6) | 25-19 | |
| » W: Storm Davis (3-1) L: Salome Barojas (0-5) | Third | 4 out |
| Friday, May 31 |
| » Defeated Athletics (22-24), 9-2 | Memorial Stadium (13-6) | 26-19 | Won 2 |
| » W: Dennis Martinez (4-3) L: Bill Krueger (4-5) S: Nate Snell (2) | Second | 4 out |
| Saturday, June 1 |
| » Lost to Athletics (23-24), 3-1 | Memorial Stadium (13-7) | 26-20 | |
| » W: Don Sutton (4-5) L: Mike Boddicker (6-4) S: Jay Howell (11) | Second | 5 out |
| Sunday, June 2 |
| » Defeated Athletics (23-25), 10-1 | Memorial Stadium (14-7) | 27-20 | |
| » W: Scott McGregor (4-4) L: Mike Warren (1-4) | Second | 4½ out |
| » Major-league debuts: Charlie O'Brien (Athletics) |
| Monday, June 3 |
| » Defeated Angels (27-22), 7-5 | Memorial Stadium (15-7) | 28-20 | Won 2 |
| » W: Sammy Stewart (2-1) L: Donnie Moore (3-3) | Second | 4 out |
| Tuesday, June 4 |
| » Lost to Angels (28-22), 6-5 | Memorial Stadium (15-8) | 28-21 | |
| » W: Stew Cliburn (2-1) L: Ken Dixon (4-3) | Second | 5 out |
| Wednesday, June 5 |
| » Defeated Angels (28-23), 4-0 | Memorial Stadium (16-8) | 29-21 | |
| » W: Dennis Martinez (5-3) L: Kirk McCaskill (0-4) | Second | 5 out |
| Friday, June 7 |
| » Lost to Red Sox (26-25), 8-4 | Memorial Stadium (16-9) | 29-22 | |
| » W: Al Nipper (2-5) L: Mike Boddicker (6-5) | Second | 6½ out |
| Saturday, June 8 |
| » Lost to Red Sox (27-25), 2-1 | Memorial Stadium (16-10) | 29-23 | Lost 2 |
| » W: Bruce Kison (3-1) L: Scott McGregor (4-5) S: Bob Stanley (7) | Second | 6½ out |
| Sunday, June 9 |
| » Lost to Red Sox (28-25), 12-0 | Memorial Stadium (16-11) | 29-24 | Lost 3 |
| » W: Oil Can Boyd (7-4) L: Storm Davis (3-2) | Second | 6½ out |
| Monday, June 10 |
| » Lost to Tigers (30-24), 8-7 | Tiger Stadium (0-1) | 29-25 | Lost 4 |
| » W: Aurelio Lopez (1-4) L: Sammy Stewart (2-2) | Third | 6½ out |
| Wednesday, June 12 |
| » Lost to Tigers (31-24), 6-2 | Tiger Stadium (0-2) | 29-26 | Lost 5 |
| » W: Dan Petry (9-4) L: Mike Boddicker (6-6) | Fourth | 8 out |
| Thursday, June 13 |
| » Defeated Brewers (27-28), 8-3 | Memorial Stadium (17-11) | 30-26 | |
| » Manager: Cal Ripken Sr. |
| » W: Scott McGregor (5-5) L: Ray Burris (3-5) | Fourth | 7 out |
| Friday, June 14 |
| » Defeated Brewers (27-29), 9-3 | Memorial Stadium (18-11) | 31-26 | Won 2 |
| » Manager: Earl Weaver |
| » W: Storm Davis (4-2) L: Pete Vuckovich (2-4) | Fourth | 6 out |
| Saturday, June 15 |
| » Defeated Brewers (27-30), 7-5 | Memorial Stadium (19-11) | 32-26 | Won 3 |
| » W: Nate Snell (1-1) L: Bob Gibson (5-4) S: Tippy Martinez (3) | Fourth | 5 out |
| Sunday, June 16 |
| » Defeated Brewers (27-31), 9-1 | Memorial Stadium (20-11) | 33-26 | Won 4 |
| » W: Mike Boddicker (7-6) L: Danny Darwin (6-5) | Fourth | 4 out |
| Monday, June 17 |
| » Lost to Yankees (30-29), 10-0 | Memorial Stadium (20-12) | 33-27 | |
| » W: Ron Guidry (7-3) L: Scott McGregor (5-6) | Fourth | 4 out |
| Tuesday, June 18 |
| » Lost to Yankees (31-29), 6-4 | Memorial Stadium (20-13) | 33-28 | Lost 2 |
| » W: Joe Cowley (5-3) L: Storm Davis (4-3) S: Brian Fisher (2) | Fourth | 4 out |
| Wednesday, June 19 |
| » Lost to Yankees (32-29), 10-0 | Memorial Stadium (20-14) | 33-29 | Lost 3 |
| » W: Ed Whitson (2-6) L: Dennis Martinez (5-4) | Fourth | 5 out |
| Friday, June 21 |
| » Lost to Brewers (30-32), 13-10 | County Stadium (0-1) | 33-30 | Lost 4 |
| » W: Jaime Cocanower (1-0) L: Sammy Stewart (2-3) S: Bob Gibson (4) | Fourth | 6½ out |
| Saturday, June 22 |
| » Defeated Brewers (30-33), 3-2 | County Stadium (1-1) | 34-30 | |
| » W: Scott McGregor (6-6) L: Danny Darwin (6-6) S: Don Aase (2) | Fourth | 5½ out |
| Sunday, June 23 |
| » Defeated Brewers (30-34), 6-3 | County Stadium (2-1) | 35-30 | Won 2 |
| » W: Nate Snell (2-1) L: Rollie Fingers (0-3) | Third | 5½ out |
| Monday, June 24 |
| » Lost to Yankees (34-32), 5-4 | Yankee Stadium (0-1) | 35-31 | |
| » W: Joe Cowley (6-3) L: Dennis Martinez (5-5) S: Brian Fisher (3) | Fourth | 6 out |
| Tuesday, June 25 |
| » Lost to Yankees (35-32), 7-4 | Yankee Stadium (0-2) | 35-32 | Lost 2 |
| » W: Ed Whitson (3-6) L: Mike Boddicker (7-7) S: Dave Righetti (12) | Fourth | 7 out |
| Wednesday, June 26 |
| » Lost to Yankees (36-32), 4-3 | Yankee Stadium (0-3) | 35-33 | Lost 3 |
| » W: Dave Righetti (5-6) L: Don Aase (4-3) | Fifth | 7 out |
| Friday, June 28 |
| » Lost to Red Sox (38-33), 6-1 | Fenway Park (0-1) | 35-34 | Lost 4 |
| » W: Bruce Hurst (3-7) L: Storm Davis (4-4) | Fifth | 8½ out |
| Saturday, June 29 |
| » Defeated Red Sox (38-34), 16-4 | Fenway Park (1-1) | 36-34 | |
| » W: Dennis Martinez (6-5) L: Oil Can Boyd (9-6) S: Nate Snell (3) | Fifth | 7½ out |
| Sunday, June 30 |
| » Defeated Red Sox (38-35), 3-0 | Fenway Park (2-1) | 37-34 | Won 2 |
| » W: Mike Boddicker (8-7) L: Bob Ojeda (4-3) | Fourth | 7½ out |
| Monday, July 1 |
| » Lost to Tigers (42-30), 7-1 | Memorial Stadium (20-15) | 37-35 | |
| » W: Randy O'Neal (4-1) L: Scott McGregor (6-7) | Fifth | 7½ out |
| Tuesday, July 2 |
| » Defeated Tigers (42-31), 5-4 | Memorial Stadium (21-15) | 38-35 | |
| » W: Don Aase (5-3) L: Willie Hernandez (4-4) | Fourth | 6½ out |
| Wednesday, July 3 |
| » Lost to Tigers (43-31), 4-3 | Memorial Stadium (21-16) | 38-36 | |
| » W: Dan Petry (10-6) L: Sammy Stewart (2-4) | Fourth | 7½ out |
| Thursday, July 4 |
| » Defeated Royals (39-37), 5-3 | Royals Stadium (2-1) | 39-36 | |
| » W: Dennis Martinez (7-5) L: Bud Black (5-9) S: Nate Snell (4) | Fourth | 6½ out |
| Friday, July 5 |
| » Defeated Royals (39-38), 6-3 | Royals Stadium (3-1) | 40-36 | Won 2 |
| » W: Mike Boddicker (9-7) L: Mark Gubicza (6-5) S: Sammy Stewart (6) | Fourth | 6½ out |
| Saturday, July 6 |
| » Defeated Royals (39-39), 8-3 | Royals Stadium (4-1) | 41-36 | Won 3 |
| » W: Scott McGregor (7-7) L: Danny Jackson (6-6) | Fourth | 5½ out |
| Sunday, July 7 |
| » Lost to Royals (40-39), 8-4 | Royals Stadium (4-2) | 41-37 | |
| » W: Charlie Leibrandt (8-5) L: Storm Davis (4-5) S: Dan Quisenberry (16) | Fourth | 6½ out |
| Monday, July 8 |
| » Lost to Twins (36-43), 7-4 | Memorial Stadium (21-17) | 41-38 | Lost 2 |
| » W: Ron Davis (2-5) L: Don Aase (5-4) | Fourth | 7½ out |
| Tuesday, July 9 |
| » Defeated Twins (36-44), 11-6 | Memorial Stadium (22-17) | 42-38 | |
| » W: Nate Snell (3-1) L: Ken Schrom (7-8) | Fourth | 7½ out |
| Wednesday, July 10 |
| » Lost to Twins (37-44), 2-1 | Memorial Stadium (22-18) | 42-39 | |
| » W: Frank Viola (10-6) L: Mike Boddicker (9-8) S: Ron Davis (10) | Fourth | 8½ out |
| Thursday, July 11 |
| » Defeated White Sox (40-41), 7-6 | Memorial Stadium (23-18) | 43-39 | |
| » W: Sammy Stewart (3-4) L: Mike Stanton (1-3) | Fourth | 8½ out |
| Friday, July 12 |
| » Defeated White Sox (40-42), 10-3 | Memorial Stadium (24-18) | 44-39 | Won 2 |
| » W: Ken Dixon (5-3) L: Gene Nelson (5-4) S: Don Aase (3) | Third | 7½ out |
| Saturday, July 13 |
| » Lost to White Sox (41-42), 10-8 | Memorial Stadium (24-19) | 44-40 | |
| » W: Britt Burns (9-6) L: Dennis Martinez (7-6) | Fourth | 7½ out |
| Sunday, July 14 |
| » Lost to White Sox (42-42), 5-3 | Memorial Stadium (24-20) | 44-41 | Lost 2 |
| » W: Tom Seaver (9-7) L: Mike Boddicker (9-9) S: Dan Spillner (1) | Fourth | 7½ out |
| Thursday, July 18 |
| » Defeated Royals (44-43), 8-3 | Memorial Stadium (25-20) | 45-41 | |
| » W: Scott McGregor (8-7) L: Bret Saberhagen (10-5) S: Sammy Stewart (7) | Fifth | 6½ out |
| Friday, July 19 |
| » Lost to Royals (45-43), 10-3 | Memorial Stadium (25-21) | 45-42 | |
| » W: Charlie Leibrandt (9-5) L: Mike Boddicker (9-10) | Fifth | 7½ out |
| Saturday, July 20 |
| » Lost to Royals (46-43), 7-5 | Memorial Stadium (25-22) | 45-43 | Lost 2 |
| » W: Danny Jackson (8-6) L: Mike Flanagan (0-1) S: Dan Quisenberry (18) | Fifth | 7½ out |
| Sunday, July 21 |
| » Defeated Royals (46-44), 6-4 | Memorial Stadium (26-22) | 46-43 | |
| » W: Tippy Martinez (2-2) L: Bud Black (6-11) S: Don Aase (4) | Fourth | 7½ out |
| Monday, July 22 |
| » Lost to Twins (42-48), 5-4 | Hubert H. Humphrey Metrodome (2-2) | 46-44 | |
| » W: Mike Smithson (9-7) L: Storm Davis (4-6) S: Ron Davis (13) | Fifth | 8½ out |
| Tuesday, July 23 |
| » Lost to Twins (43-48), 5-2 | Hubert H. Humphrey Metrodome (2-3) | 46-45 | Lost 2 |
| » W: John Butcher (7-9) L: Scott McGregor (8-8) S: Ron Davis (14) | Fifth | 9½ out |
| Wednesday, July 24 |
| » Defeated Twins (43-49), 4-2 | Hubert H. Humphrey Metrodome (3-3) | 47-45 | |
| » W: Mike Boddicker (10-10) L: Ken Schrom (8-10) S: Don Aase (5) | Fifth | 9½ out |
| Thursday, July 25 |
| » Defeated White Sox (47-45), 5-1 | Comiskey Park I (2-1) | 48-45 | Won 2 |
| » W: Mike Flanagan (1-1) L: Floyd Bannister (5-8) | Fifth | 9½ out |
| Friday, July 26 |
| » Lost to White Sox (48-45), 9-8 | Comiskey Park I (2-2) | 48-46 | |
| » W: Juan Agosto (2-1) L: Don Aase (5-5) | Fifth | 10½ out |
| Saturday, July 27 |
| » Defeated White Sox (48-46), 9-1 | Comiskey Park I (3-2) | 49-46 | |
| » W: Storm Davis (5-6) L: Gene Nelson (6-5) | Fifth | 10½ out |
| Sunday, July 28 |
| » Defeated White Sox (48-47), 6-1 | Comiskey Park I (4-2) | 50-46 | Won 2 |
| » W: Scott McGregor (9-8) L: Britt Burns (11-7) | Fifth | 10½ out |
| Monday, July 29 |
| » Lost to Blue Jays (63-37), 4-3 | Memorial Stadium (26-23) | 50-47 | |
| » W: Tom Henke (1-0) L: Mike Boddicker (10-11) | Fifth | 11½ out |
| Tuesday, July 30 |
| » Defeated Blue Jays (63-38), 4-3 | Memorial Stadium (27-23) | 51-47 | |
| » W: Don Aase (6-5) L: Gary Lavelle (3-6) | Fifth | 10½ out |
| Wednesday, July 31 |
| » Lost to Blue Jays (64-38), 5-3 | Memorial Stadium (27-24) | 51-48 | |
| » W: Tom Henke (2-0) L: Dennis Martinez (7-7) | Fifth | 11½ out |
| Thursday, August 1 |
| » Lost to Blue Jays (65-38), 9-3 | Memorial Stadium (27-25) | 51-49 | Lost 2 |
| » W: Tom Filer (3-0) L: Storm Davis (5-7) | Fifth | 12½ out |
| Friday, August 2 |
| » Defeated Indians (33-69), 8-6 | Cleveland Stadium (2-2) | 52-49 | |
| » W: Sammy Stewart (4-4) L: Rich Thompson (3-5) | Fifth | 12½ out |
| Saturday, August 3 |
| » Lost to Indians (34-69), 10-4 | Cleveland Stadium (2-3) | 52-50 | |
| » W: Curt Wardle (2-3) L: Mike Boddicker (10-12) | Fifth | 13½ out |
| Sunday, August 4 |
| » Defeated Indians (34-70), 5-4 | Cleveland Stadium (3-3) | 53-50 | |
| » W: Dennis Martinez (8-7) L: Rich Thompson (3-6) | Fourth | 12½ out |
| Thursday, August 8 |
| » Lost to Blue Jays (68-39), 7-2 | Exhibition Stadium (1-3) | 53-51 | |
| » W: Doyle Alexander (12-6) L: Scott McGregor (9-9) | Fifth | 14½ out |
| » Lost to Blue Jays (69-39), 7-4 | Exhibition Stadium (1-4) | 53-52 | Lost 2 |
| » W: Tom Filer (4-0) L: Mike Boddicker (10-13) S: Tom Henke (2) | Fifth | 14½ out |
| Friday, August 9 |
| » Lost to Rangers (41-66), 5-2 | Arlington Stadium (2-2) | 53-53 | Lost 3 |
| » W: Charlie Hough (11-11) L: Mike Flanagan (1-2) S: Dave Schmidt (5) | Fifth | 14½ out |
| Saturday, August 10 |
| » Defeated Rangers (41-67), 9-8 | Arlington Stadium (3-2) | 54-53 | |
| » W: Storm Davis (6-7) L: Chris Welsh (2-4) S: Don Aase (6) | Fifth | 13½ out |
| Sunday, August 11 |
| » Defeated Rangers (41-68), 9-4 | Arlington Stadium (4-2) | 55-53 | Won 2 |
| » W: Sammy Stewart (5-4) L: Mike Mason (5-11) | Fifth | 13½ out |
| Monday, August 12 |
| » Lost to Indians (37-73), 8-5 | Memorial Stadium (27-26) | 55-54 | |
| » W: Curt Wardle (3-4) L: Scott McGregor (9-10) S: Jerry Reed (1) | Fifth | 13½ out |
| Tuesday, August 13 |
| » Defeated Indians (37-74), 8-4 | Memorial Stadium (28-26) | 56-54 | |
| » W: Don Aase (7-5) L: Vern Ruhle (2-9) | Fourth | 13½ out |
| Wednesday, August 14 |
| » Defeated Indians (37-75), 8-4 | Memorial Stadium (29-26) | 57-54 | Won 2 |
| » W: Mike Flanagan (2-2) L: Bryan Clark (1-3) S: Nate Snell (5) | Fourth | 13½ out |
| Thursday, August 15 |
| » Defeated Rangers (42-71), 9-1 | Memorial Stadium (30-26) | 58-54 | Won 3 |
| » W: Storm Davis (7-7) L: Chris Welsh (2-5) | Fourth | 13 out |
| Friday, August 16 |
| » Defeated Rangers (42-72), 4-2 | Memorial Stadium (31-26) | 59-54 | Won 4 |
| » W: Dennis Martinez (9-7) L: Jeff Russell (0-3) S: Don Aase (7) | Fourth | 12 out |
| Saturday, August 17 |
| » Defeated Rangers (42-73), 9-2 | Memorial Stadium (32-26) | 60-54 | Won 5 |
| » W: Scott McGregor (10-10) L: Burt Hooton (5-7) | Fourth | 11 out |
| Monday, August 19 |
| » Defeated Rangers (42-74), 9-2 | Memorial Stadium (33-26) | 61-54 | Won 6 |
| » W: Ken Dixon (6-3) L: Mike Mason (5-12) | Fourth | 10½ out |
| Tuesday, August 20 |
| » Lost to Mariners (56-63), 4-3 | Kingdome (2-2) | 61-55 | |
| » W: Mike Moore (11-7) L: Nate Snell (3-2) | Fourth | 11½ out |
| Wednesday, August 21 |
| » Defeated Mariners (56-64), 11-8 | Kingdome (3-2) | 62-55 | |
| » W: Dennis Martinez (10-7) L: Jim Beattie (5-6) S: Don Aase (8) | Fourth | 10½ out |
| Thursday, August 22 |
| » Lost to Mariners (57-64), 4-0 | Kingdome (3-3) | 62-56 | |
| » W: Matt Young (8-14) L: Scott McGregor (10-11) | Fourth | 11 out |
| Friday, August 23 |
| » Defeated Athletics (63-59), 7-2 | Oakland-Alameda County Stadium (2-2) | 63-56 | |
| » W: Mike Boddicker (11-13) L: Jay Howell (9-5) | Fourth | 11½ out |
| Saturday, August 24 |
| » Defeated Athletics (63-60), 4-3 | Oakland-Alameda County Stadium (3-2) | 64-56 | Won 2 |
| » W: Don Aase (8-5) L: Keith Atherton (4-6) S: Sammy Stewart (8) | Fourth | 11½ out |
| Sunday, August 25 |
| » Lost to Athletics (64-60), 10-4 | Oakland-Alameda County Stadium (3-3) | 64-57 | |
| » W: Tim Birtsas (10-4) L: Mike Flanagan (2-3) | Fourth | 11½ out |
| Monday, August 26 |
| » Defeated Angels (71-54), 17-3 | Anaheim Stadium (3-2) | 65-57 | |
| » W: Dennis Martinez (11-7) L: John Candelaria (4-5) | Fourth | 11½ out |
| Tuesday, August 27 |
| » Lost to Angels (72-54), 7-3 | Anaheim Stadium (3-3) | 65-58 | |
| » W: Mike Witt (12-7) L: Scott McGregor (10-12) S: Donnie Moore (23) | Fourth | 12½ out |
| Wednesday, August 28 |
| » Major-league debuts: Todd Worrell (Cardinals) |
| Thursday, August 29 |
| » Defeated Mariners (58-69), 7-0 | Memorial Stadium (34-26) | 66-58 | |
| » W: Mike Boddicker (12-13) L: Bill Swift (4-8) | Fourth | 11½ out |
| Friday, August 30 |
| » Defeated Mariners (58-70), 6-0 | Memorial Stadium (35-26) | 67-58 | Won 2 |
| » W: Storm Davis (8-7) L: Mark Langston (7-11) | Third | 11½ out |
| Saturday, August 31 |
| » Lost to Mariners (59-70), 6-0 | Memorial Stadium (35-27) | 67-59 | |
| » W: Mike Moore (12-8) L: Mike Flanagan (2-4) | Fourth | 12½ out |
| Sunday, September 1 |
| » Lost to Mariners (60-70), 10-2 | Memorial Stadium (35-28) | 67-60 | Lost 2 |
| » W: Matt Young (10-14) L: Dennis Martinez (11-8) | Fourth | 12½ out |
| Monday, September 2 |
| » Defeated Athletics (67-64), 12-4 | Memorial Stadium (36-28) | 68-60 | |
| » W: Scott McGregor (11-12) L: Tommy John (4-6) S: Ken Dixon (1) | Fourth | 12½ out |
| » Major-league debuts: Jose Canseco (Athletics) |
| Tuesday, September 3 |
| » Lost to Athletics (68-64), 3-2 | Memorial Stadium (36-29) | 68-61 | |
| » W: Jose Rijo (3-1) L: Mike Boddicker (12-14) S: Jay Howell (24) | Fourth | 13 out |
| Wednesday, September 4 |
| » Defeated Athletics (68-65), 6-1 | Memorial Stadium (37-29) | 69-61 | |
| » W: Storm Davis (9-7) L: Don Sutton (13-8) | Fourth | 12 out |
| Friday, September 6 |
| » Defeated Angels (75-59), 6-2 | Memorial Stadium (38-29) | 70-61 | Won 2 |
| » W: Dennis Martinez (12-8) L: Ron Romanick (13-7) S: Sammy Stewart (9) | Fourth | 12½ out |
| Saturday, September 7 |
| » Defeated Angels (75-60), 4-3 | Memorial Stadium (39-29) | 71-61 | Won 3 |
| » W: Don Aase (9-5) L: Donnie Moore (7-8) | Third | 11½ out |
| » Major-league debuts: Gus Polidor (Angels) |
| Sunday, September 8 |
| » Lost to Angels (76-60), 7-4 | Memorial Stadium (39-30) | 71-62 | |
| » W: Donnie Moore (8-8) L: Tippy Martinez (2-3) | Third | 12½ out |
| Tuesday, September 10 |
| » Defeated Red Sox (67-70), 7-5 | Fenway Park (3-1) | 72-62 | |
| » W: Storm Davis (10-7) L: Bruce Hurst (10-11) S: Don Aase (9) | Third | 13½ out |
| » Lost to Red Sox (68-70), 5-3 | Fenway Park (3-2) | 72-63 | |
| » W: Oil Can Boyd (13-11) L: Mike Boddicker (12-15) S: Steve Crawford (9) | Third | 13½ out |
| Wednesday, September 11 |
| » Lost to Red Sox (69-70), 4-1 | Fenway Park (3-3) | 72-64 | Lost 2 |
| » W: Bob Ojeda (7-9) L: Dennis Martinez (12-9) | Third | 14½ out |
| Thursday, September 12 |
| » Defeated Red Sox (69-71), 3-1 | Fenway Park (4-3) | 73-64 | |
| » W: Ken Dixon (7-3) L: Al Nipper (8-11) S: Don Aase (10) | Third | 13½ out |
| Friday, September 13 |
| » Defeated Tigers (71-68), 6-4 | Tiger Stadium (1-2) | 74-64 | Won 2 |
| » W: Scott McGregor (12-12) L: Juan Berenguer (4-5) S: Don Aase (11) | Third | 13½ out |
| Saturday, September 14 |
| » Lost to Tigers (72-68), 10-3 | Tiger Stadium (1-3) | 74-65 | |
| » W: Frank Tanana (8-14) L: Mike Boddicker (12-16) | Third | 14 out |
| » Defeated Tigers (72-69), 5-4 | Tiger Stadium (2-3) | 75-65 | |
| » W: Mike Flanagan (3-4) L: Mickey Mahler (1-6) S: Tippy Martinez (4) | Third | 14 out |
| Sunday, September 15 |
| » Lost to Tigers (73-69), 4-1 | Tiger Stadium (2-4) | 75-66 | |
| » W: Willie Hernandez (8-9) L: Sammy Stewart (5-5) | Third | 15 out |
| Monday, September 16 |
| » Defeated Tigers (73-70), 14-7 | Tiger Stadium (3-4) | 76-66 | |
| » W: Tippy Martinez (3-3) L: Chuck Cary (0-1) S: Don Aase (12) | Third | 14½ out |
| Tuesday, September 17 |
| » Defeated Brewers (63-80), 6-0 | Memorial Stadium (40-30) | 77-66 | Won 2 |
| » W: Ken Dixon (8-3) L: Teddy Higuera (13-7) | Third | 13½ out |
| Wednesday, September 18 |
| » Defeated Brewers (63-81), 4-2 | Memorial Stadium (41-30) | 78-66 | Won 3 |
| » W: Scott McGregor (13-12) L: Tim Leary (1-1) | Third | 12½ out |
| Thursday, September 19 |
| » Lost to Brewers (64-81), 5-2 | Memorial Stadium (41-31) | 78-67 | |
| » W: Bill Wegman (1-0) L: Mike Boddicker (12-17) S: Bob McClure (1) | Third | 13 out |
| Friday, September 20 |
| » Defeated Yankees (86-61), 4-2 | Memorial Stadium (42-31) | 79-67 | |
| » W: Mike Flanagan (4-4) L: Rich Bordi (5-8) S: Don Aase (13) | Third | 13 out |
| Saturday, September 21 |
| » Lost to Yankees (87-61), 5-2 | Memorial Stadium (42-32) | 79-68 | |
| » W: Joe Cowley (11-5) L: Storm Davis (10-8) S: Brian Fisher (13) | Third | 14 out |
| Sunday, September 22 |
| » Lost to Yankees (88-61), 5-4 | Memorial Stadium (42-33) | 79-69 | Lost 2 |
| » W: Ron Guidry (20-6) L: Ken Dixon (8-4) S: Dave Righetti (26) | Third | 14 out |
| Tuesday, September 24 |
| » Lost to Brewers (66-84), 10-6 | County Stadium (2-2) | 79-70 | Lost 3 |
| » W: Bill Wegman (2-0) L: Scott McGregor (13-13) S: Bob McClure (2) | Third | 15½ out |
| » Major-league debuts: Eric Bell (Orioles) |
| Wednesday, September 25 |
| » Lost to Brewers (67-84), 3-0 | County Stadium (2-3) | 79-71 | Lost 4 |
| » W: Jaime Cocanower (5-7) L: Mike Flanagan (4-5) | Third | 15½ out |
| Thursday, September 26 |
| » Defeated Brewers (67-85), 9-1 | County Stadium (3-3) | 80-71 | |
| » W: Dennis Martinez (13-9) L: Moose Haas (8-8) | Third | 14½ out |
| Saturday, September 28 |
| » Lost to Yankees (90-62), 6-5 | Yankee Stadium (0-4) | 80-72 | |
| » W: Ron Guidry (21-6) L: Sammy Stewart (5-6) | Third | 16 out |
| Sunday, September 29 |
| » Lost to Yankees (91-62), 4-0 | |