| Monday, April 8 |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Tuesday, April 9 |
| » Defeated Athletics (0-1), 6-3 | Kingdome (1-0) | 1-0 | |
| » W: Mike Moore (1-0) L: Chris Codiroli (0-1) S: Edwin Nunez (1) | First | -- |
| Wednesday, April 10 |
| » Defeated Athletics (0-2), 5-4 | Kingdome (2-0) | 2-0 | Won 2 |
| » W: Mark Langston (1-0) L: Bill Krueger (0-1) S: Edwin Nunez (2) | First | -- |
| Thursday, April 11 |
| » Defeated Athletics (0-3), 14-6 | Kingdome (3-0) | 3-0 | Won 3 |
| » W: Mike Morgan (1-0) L: Curt Young (0-1) | First | -- |
| » Major-league debuts: Mike Gallego and Jeff Kaiser (Athletics) |
| Friday, April 12 |
| » Defeated Twins (2-2), 2-1 | Kingdome (4-0) | 4-0 | Won 4 |
| » W: Matt Young (1-0) L: Ken Schrom (0-1) S: Edwin Nunez (3) | First | -- |
| Saturday, April 13 |
| » Defeated Twins (2-3), 8-7 | Kingdome (5-0) | 5-0 | Won 5 |
| » W: Mike Stanton (1-0) L: Ron Davis (0-1) | First | -- |
| » Major-league debuts: Rich Yett (Twins) |
| Sunday, April 14 |
| » Defeated Twins (2-4), 5-1 | Kingdome (6-0) | 6-0 | Won 6 |
| » W: Mike Moore (2-0) L: Frank Viola (1-1) | First | -- |
| Monday, April 15 |
| » Lost to Athletics (3-4), 7-4 | Oakland-Alameda County Stadium (0-1) | 6-1 | |
| » W: Bill Krueger (1-1) L: Mark Langston (1-1) S: Jay Howell (2) | First | -- |
| Tuesday, April 16 |
| » Lost to Athletics (4-4), 9-7 | Oakland-Alameda County Stadium (0-2) | 6-2 | Lost 2 |
| » W: Mike Warren (1-1) L: Mike Morgan (1-1) S: Jay Howell (3) | First | -- |
| Wednesday, April 17 |
| » Lost to Athletics (5-4), 8-4 | Oakland-Alameda County Stadium (0-3) | 6-3 | Lost 3 |
| » W: Don Sutton (2-0) L: Matt Young (1-1) | First | -- |
| Friday, April 19 |
| » Lost to Angels (6-4), 9-1 | Anaheim Stadium (0-1) | 6-4 | Lost 4 |
| » W: Ron Romanick (2-0) L: Mike Moore (2-1) | First | -- |
| Saturday, April 20 |
| » Defeated Angels (6-5), 3-2 | Anaheim Stadium (1-1) | 7-4 | |
| » W: Mark Langston (2-1) L: Mike Witt (0-3) S: Ed Vande Berg (1) | First | -- |
| Sunday, April 21 |
| » Lost to Angels (7-5), 9-2 | Anaheim Stadium (1-2) | 7-5 | |
| » W: Geoff Zahn (2-0) L: Jim Beattie (0-1) | First | -- |
| Monday, April 22 |
| » Lost to Twins (4-9), 9-5 | Hubert H. Humphrey Metrodome (0-1) | 7-6 | Lost 2 |
| » W: Ken Schrom (1-2) L: Matt Young (1-2) S: Rick Lysander (1) | Second | 1 out |
| Tuesday, April 23 |
| » Lost to Twins (5-9), 4-2 | Hubert H. Humphrey Metrodome (0-2) | 7-7 | Lost 3 |
| » W: Frank Viola (2-2) L: Salome Barojas (0-1) | Fourth | 1 out |
| Wednesday, April 24 |
| » Lost to Twins (6-9), 10-0 | Hubert H. Humphrey Metrodome (0-3) | 7-8 | Lost 4 |
| » W: Mike Smithson (2-2) L: Mike Moore (2-2) | Fourth | 2 out |
| Thursday, April 25 |
| » Lost to Angels (9-7), 3-0 | Kingdome (6-1) | 7-9 | Lost 5 |
| » W: Mike Witt (1-3) L: Mark Langston (2-2) | Fourth | 2 out |
| Friday, April 26 |
| » Lost to Angels (10-7), 11-3 | Kingdome (6-2) | 7-10 | Lost 6 |
| » W: Doug Corbett (2-0) L: Jim Beattie (0-2) S: Stew Cliburn (1) | Sixth | 3 out |
| Saturday, April 27 |
| » Lost to Angels (11-7), 6-1 | Kingdome (6-3) | 7-11 | Lost 7 |
| » W: Jim Slaton (3-0) L: Matt Young (1-3) | Fifth | 4 out |
| Sunday, April 28 |
| » Lost to Angels (12-7), 2-1 | Kingdome (6-4) | 7-12 | Lost 8 |
| » W: Tommy John (1-1) L: Salome Barojas (0-2) S: Donnie Moore (3) | Sixth | 5 out |
| » Major-league debuts: Urbano Lugo (Angels) |
| Monday, April 29 |
| » Defeated Brewers (8-10), 9-7 | Kingdome (7-4) | 8-12 | |
| » W: Edwin Nunez (1-0) L: Ray Searage (0-2) | Sixth | 5 out |
| Tuesday, April 30 |
| » Defeated Brewers (8-11), 4-2 | Kingdome (8-4) | 9-12 | Won 2 |
| » W: Mark Langston (3-2) L: Bob Gibson (3-1) S: Edwin Nunez (4) | Fifth | 5 out |
| Wednesday, May 1 |
| » Defeated Red Sox (9-12), 7-0 | Kingdome (9-4) | 10-12 | Won 3 |
| » W: Jim Beattie (1-2) L: Roger Clemens (2-3) | Fifth | 4 out |
| Thursday, May 2 |
| » Lost to Red Sox (10-12), 2-1 | Kingdome (9-5) | 10-13 | |
| » W: Al Nipper (1-1) L: Mike Moore (2-3) S: Bob Stanley (4) | Fifth | 5 out |
| Friday, May 3 |
| » Lost to Blue Jays (15-8), 5-4 | Kingdome (9-6) | 10-14 | Lost 2 |
| » W: Doyle Alexander (4-0) L: Salome Barojas (0-3) S: Bill Caudill (6) | Fifth | 5 out |
| Saturday, May 4 |
| » Defeated Blue Jays (15-9), 8-1 | Kingdome (10-6) | 11-14 | |
| » W: Matt Young (2-3) L: Luis Leal (2-2) | Fifth | 5 out |
| Sunday, May 5 |
| » Defeated Blue Jays (15-10), 4-1 | Kingdome (11-6) | 12-14 | Won 2 |
| » W: Mark Langston (4-2) L: Jim Clancy (0-1) | Fifth | 5 out |
| Tuesday, May 7 |
| » Lost to Brewers (11-14), 5-2 | County Stadium (0-1) | 12-15 | |
| » W: Moose Haas (2-2) L: Jim Beattie (1-3) | Fifth | 5 out |
| Wednesday, May 8 |
| » Defeated Brewers (11-15), 4-2 | County Stadium (1-1) | 13-15 | |
| » W: Mike Moore (3-3) L: Ray Burris (1-4) S: Edwin Nunez (5) | Fifth | 4 out |
| Friday, May 10 |
| » Lost to Blue Jays (17-11), 8-3 | Exhibition Stadium (0-1) | 13-16 | |
| » W: Jimmy Key (2-2) L: Mark Langston (4-3) S: Jim Acker (4) | Fifth | 5 out |
| Saturday, May 11 |
| » Lost to Blue Jays (18-11), 4-2 | Exhibition Stadium (0-2) | 13-17 | Lost 2 |
| » W: Bill Caudill (4-2) L: Matt Young (2-4) | Fifth | 6 out |
| Sunday, May 12 |
| » Lost to Blue Jays (19-11), 9-5 | Exhibition Stadium (0-3) | 13-18 | Lost 3 |
| » W: Dave Stieb (3-3) L: Jim Beattie (1-4) | Sixth | 6 out |
| Tuesday, May 14 |
| » Defeated Red Sox (15-16), 5-0 | Fenway Park (1-0) | 14-18 | |
| » W: Mike Moore (4-3) L: Oil Can Boyd (4-2) | Sixth | 5 out |
| Wednesday, May 15 |
| » Defeated Red Sox (15-17), 7-1 | Fenway Park (2-0) | 15-18 | Won 2 |
| » W: Mark Langston (5-3) L: Al Nipper (1-2) | Sixth | 5 out |
| Friday, May 17 |
| » Lost to Orioles (20-13), 11-3 | Kingdome (11-7) | 15-19 | |
| » W: Ken Dixon (4-1) L: Matt Young (2-5) S: Nate Snell (1) | Sixth | 5 out |
| Saturday, May 18 |
| » Defeated Orioles (20-14), 8-7 | Kingdome (12-7) | 16-19 | |
| » W: Edwin Nunez (2-0) L: Tippy Martinez (1-2) | Fifth | 4 out |
| Sunday, May 19 |
| » Lost to Orioles (21-14), 2-1 | Kingdome (12-8) | 16-20 | |
| » W: Dennis Martinez (3-2) L: Mike Moore (4-4) | Sixth | 5 out |
| Tuesday, May 21 |
| » Lost to Yankees (19-16), 11-1 | Kingdome (12-9) | 16-21 | Lost 2 |
| » W: Ron Guidry (4-3) L: Mark Langston (5-4) | Sixth | 6½ out |
| Wednesday, May 22 |
| » Defeated Yankees (19-17), 4-1 | Kingdome (13-9) | 17-21 | |
| » W: Matt Young (3-5) L: Dennis Rasmussen (2-2) | Sixth | 5½ out |
| Thursday, May 23 |
| » Defeated Yankees (19-18), 6-4 | Kingdome (14-9) | 18-21 | Won 2 |
| » W: Jim Beattie (2-4) L: Phil Niekro (5-3) S: Karl Best (1) | Sixth | 5 out |
| Friday, May 24 |
| » Lost to Tigers (22-16), 4-3 | Kingdome (14-10) | 18-22 | |
| » W: Willie Hernandez (3-1) L: Mike Stanton (1-1) | Sixth | 5 out |
| Saturday, May 25 |
| » Lost to Tigers (23-16), 3-2 | Kingdome (14-11) | 18-23 | Lost 2 |
| » W: Walt Terrell (5-1) L: Karl Best (0-1) S: Willie Hernandez (10) | Sixth | 6 out |
| » Major-league debuts: Bob Melvin (Tigers) |
| Sunday, May 26 |
| » Lost to Tigers (24-16), 6-0 | Kingdome (14-12) | 18-24 | Lost 3 |
| » W: Jack Morris (6-4) L: Salome Barojas (0-4) | Sixth | 7 out |
| Monday, May 27 |
| » Defeated Tigers (24-17), 5-2 | Kingdome (15-12) | 19-24 | |
| » W: Matt Young (4-5) L: Dan Petry (8-3) S: Karl Best (2) | Fifth | 6 out |
| Wednesday, May 29 |
| » Defeated Orioles (24-19), 5-4 | Memorial Stadium (1-0) | 20-24 | Won 2 |
| » W: Karl Best (1-1) L: Don Aase (4-2) | Fifth | 5 out |
| Thursday, May 30 |
| » Lost to Orioles (25-19), 8-2 | Memorial Stadium (1-1) | 20-25 | |
| » W: Storm Davis (3-1) L: Salome Barojas (0-5) | Fifth | 5 out |
| Friday, May 31 |
| » Lost to Yankees (24-20), 8-3 | Yankee Stadium (0-1) | 20-26 | Lost 2 |
| » W: Brian Fisher (2-0) L: Mark Langston (5-5) | Sixth | 6 out |
| Saturday, June 1 |
| » Lost to Yankees (25-20), 8-2 | Yankee Stadium (0-2) | 20-27 | Lost 3 |
| » W: Ron Guidry (6-3) L: Matt Young (4-6) | Sixth | 7 out |
| Sunday, June 2 |
| » Defeated Yankees (25-21), 7-6 | Yankee Stadium (1-2) | 21-27 | |
| » W: Edwin Nunez (3-0) L: Dennis Rasmussen (2-3) S: Karl Best (3) | Sixth | 6 out |
| Monday, June 3 |
| » Defeated Tigers (26-21), 9-8 | Tiger Stadium (1-0) | 22-27 | Won 2 |
| » W: Jim Beattie (3-4) L: Aurelio Lopez (0-3) S: Mike Stanton (1) | Sixth | 5 out |
| Tuesday, June 4 |
| » Defeated Tigers (26-22), 7-6 | Tiger Stadium (2-0) | 23-27 | Won 3 |
| » W: Roy Thomas (1-0) L: Willie Hernandez (4-2) S: Matt Young (1) | Fifth | 5 out |
| Wednesday, June 5 |
| » Lost to Tigers (27-22), 5-2 | Tiger Stadium (2-1) | 23-28 | |
| » W: Jack Morris (7-5) L: Mark Langston (5-6) | Fifth | 5 out |
| Thursday, June 6 |
| » Lost to Indians (18-34), 9-1 | Cleveland Stadium (0-1) | 23-29 | Lost 2 |
| » W: Bert Blyleven (4-6) L: Matt Young (4-7) | Fifth | 5½ out |
| Friday, June 7 |
| » Defeated Indians (18-35), 6-4 | Cleveland Stadium (1-1) | 24-29 | |
| » W: Bill Swift (1-0) L: Neal Heaton (4-5) S: Ed Vande Berg (2) | Fifth | 4½ out |
| » Major-league debuts: Bill Swift (Mariners) |
| Saturday, June 8 |
| » Lost to Indians (19-35), 12-8 | Cleveland Stadium (1-2) | 24-30 | |
| » W: Tom Waddell (2-3) L: Mike Stanton (1-2) | Fifth | 5 out |
| Sunday, June 9 |
| » Defeated Indians (19-36), 10-6 | Cleveland Stadium (2-2) | 25-30 | |
| » W: Frank Wills (1-0) L: Don Schulze (3-6) S: Edwin Nunez (6) | Fifth | 4½ out |
| Monday, June 10 |
| » Lost to White Sox (28-24), 9-4 | Kingdome (15-13) | 25-31 | |
| » W: Floyd Bannister (5-4) L: Matt Young (4-8) S: Bob James (13) | Fifth | 5½ out |
| Tuesday, June 11 |
| » Lost to White Sox (29-24), 7-1 | Kingdome (15-14) | 25-32 | Lost 2 |
| » W: Tim Lollar (2-2) L: Bill Swift (1-1) | Sixth | 6 out |
| Wednesday, June 12 |
| » Lost to White Sox (30-24), 6-3 | Kingdome (15-15) | 25-33 | Lost 3 |
| » W: Bruce Tanner (1-0) L: Brian Snyder (0-1) S: Bob James (14) | Sixth | 7 out |
| » Major-league debuts: Bruce Tanner (White Sox) |
| Thursday, June 13 |
| » Lost to Royals (30-27), 4-3 | Kingdome (15-16) | 25-34 | Lost 4 |
| » W: Mark Gubicza (3-4) L: Bill Wilkinson (0-1) S: Dan Quisenberry (12) | Sixth | 7½ out |
| » Major-league debuts: Bill Wilkinson (Mariners) |
| Friday, June 14 |
| » Defeated Royals (30-28), 13-5 | Kingdome (16-16) | 26-34 | |
| » W: Frank Wills (2-0) L: Danny Jackson (4-4) | Sixth | 7 out |
| Saturday, June 15 |
| » Defeated Royals (30-29), 2-1 | Kingdome (17-16) | 27-34 | Won 2 |
| » W: Matt Young (5-8) L: Charlie Leibrandt (6-4) S: Ed Vande Berg (3) | Fifth | 7 out |
| Sunday, June 16 |
| » Defeated Royals (30-30), 2-1 | Kingdome (18-16) | 28-34 | Won 3 |
| » W: Karl Best (2-1) L: Joe Beckwith (1-3) | Fifth | 6 out |
| Tuesday, June 18 |
| » Lost to Rangers (25-38), 8-5 | Arlington Stadium (0-1) | 28-35 | |
| » W: Frank Tanana (2-7) L: Bill Wilkinson (0-2) S: Dave Rozema (4) | Fifth | 7 out |
| Wednesday, June 19 |
| » Lost to Rangers (26-38), 5-4 | Arlington Stadium (0-2) | 28-36 | Lost 2 |
| » W: Chris Welsh (1-1) L: Frank Wills (2-1) S: Greg Harris (5) | Fifth | 8 out |
| Thursday, June 20 |
| » Defeated Rangers (26-39), 11-3 | Arlington Stadium (1-2) | 29-36 | |
| » W: Matt Young (6-8) L: Burt Hooton (3-2) S: Karl Best (4) | Fifth | 7 out |
| Saturday, June 22 |
| » Defeated Royals (33-32), 2-1 | Royals Stadium (1-0) | 30-36 | Won 2 |
| » W: Bill Swift (2-1) L: Bret Saberhagen (7-4) S: Edwin Nunez (7) | Fifth | 7 out |
| Sunday, June 23 |
| » Defeated Royals (33-33), 8-2 | Royals Stadium (2-0) | 31-36 | Won 3 |
| » W: Mike Moore (5-4) L: Bud Black (5-7) | Fifth | 7 out |
| Monday, June 24 |
| » Defeated Rangers (27-42), 2-0 | Kingdome (19-16) | 32-36 | Won 4 |
| » W: Frank Wills (3-1) L: Chris Welsh (1-2) S: Edwin Nunez (8) | Fifth | 6 out |
| Tuesday, June 25 |
| » Defeated Rangers (27-43), 2-1 | Kingdome (20-16) | 33-36 | Won 5 |
| » W: Matt Young (7-8) L: Charlie Hough (5-9) S: Edwin Nunez (9) | Fifth | 6 out |
| Wednesday, June 26 |
| » Defeated Rangers (27-44), 5-4 | Kingdome (21-16) | 34-36 | Won 6 |
| » W: Roy Thomas (2-0) L: Dave Stewart (0-4) | Fifth | 6 out |
| » Major-league debuts: Bob Sebra (Rangers) |
| Friday, June 28 |
| » Defeated Indians (22-48), 8-6 | Kingdome (22-16) | 35-36 | Won 7 |
| » W: Roy Thomas (3-0) L: Jeff Barkley (0-3) S: Edwin Nunez (10) | Fifth | 5 out |
| Saturday, June 29 |
| » Defeated Indians (22-49), 3-2 | Kingdome (23-16) | 36-36 | Won 8 |
| » W: Mike Moore (6-4) L: Bert Blyleven (7-7) S: Edwin Nunez (11) | Fifth | 5 out |
| Sunday, June 30 |
| » Lost to Indians (23-49), 7-3 | Kingdome (23-17) | 36-37 | |
| » W: Rich Thompson (2-2) L: Matt Young (7-9) S: Tom Waddell (9) | Fifth | 5 out |
| Monday, July 1 |
| » Defeated White Sox (35-36), 3-1 | Comiskey Park I (1-0) | 37-37 | |
| » W: Frank Wills (4-1) L: Floyd Bannister (5-7) S: Edwin Nunez (12) | Fourth | 4 out |
| Tuesday, July 2 |
| » Lost to White Sox (36-36), 12-4 | Comiskey Park I (1-1) | 37-38 | |
| » W: Tim Lollar (3-4) L: Brian Snyder (0-2) S: Bob James (17) | Fifth | 5 out |
| Wednesday, July 3 |
| » Defeated White Sox (36-37), 5-1 | Comiskey Park I (2-1) | 38-38 | |
| » W: Bill Swift (3-1) L: Dan Spillner (2-2) | Fourth | 5 out |
| Thursday, July 4 |
| » Defeated Brewers (35-39), 7-1 | Kingdome (24-17) | 39-38 | Won 2 |
| » W: Mike Moore (7-4) L: Moose Haas (7-4) | Fourth | 5 out |
| Friday, July 5 |
| » Defeated Brewers (35-40), 7-6 | Kingdome (25-17) | 40-38 | Won 3 |
| » W: Edwin Nunez (4-0) L: Rick Waits (0-1) | Third | 5 out |
| Saturday, July 6 |
| » Defeated Brewers (35-41), 5-3 | Kingdome (26-17) | 41-38 | Won 4 |
| » W: Roy Thomas (4-0) L: Pete Vuckovich (3-6) S: Brian Snyder (1) | Third | 4 out |
| Sunday, July 7 |
| » Lost to Brewers (36-41), 2-1 | Kingdome (26-18) | 41-39 | |
| » W: Teddy Higuera (5-5) L: Bill Swift (3-2) S: Rollie Fingers (10) | Third | 5 out |
| Monday, July 8 |
| » Lost to Blue Jays (50-32), 4-0 | Kingdome (26-19) | 41-40 | Lost 2 |
| » W: Dave Stieb (9-5) L: Mike Moore (7-5) | Fifth | 6 out |
| Tuesday, July 9 |
| » Lost to Blue Jays (51-32), 9-4 | Kingdome (26-20) | 41-41 | Lost 3 |
| » W: Ron Musselman (3-0) L: Ed Vande Berg (0-1) | Fifth | 7 out |
| Wednesday, July 10 |
| » Lost to Blue Jays (52-32), 11-1 | Kingdome (26-21) | 41-42 | Lost 4 |
| » W: Jim Clancy (6-4) L: Frank Wills (4-2) | Fifth | 8 out |
| Thursday, July 11 |
| » Lost to Red Sox (43-41), 7-1 | Kingdome (26-22) | 41-43 | Lost 5 |
| » W: Al Nipper (5-6) L: Bill Swift (3-3) S: Steve Crawford (3) | Fifth | 8 out |
| Friday, July 12 |
| » Lost to Red Sox (44-41), 5-4 | Kingdome (26-23) | 41-44 | Lost 6 |
| » W: Mike Trujillo (2-2) L: Edwin Nunez (4-1) S: Mark Clear (1) | Fifth | 9 out |
| Saturday, July 13 |
| » Defeated Red Sox (44-42), 6-5 | Kingdome (27-23) | 42-44 | |
| » W: Brian Snyder (1-2) L: Bob Stanley (4-5) | Fifth | 9 out |
| Sunday, July 14 |
| » Lost to Red Sox (45-42), 6-2 | Kingdome (27-24) | 42-45 | |
| » W: Oil Can Boyd (11-7) L: Frank Wills (4-3) | Fifth | 10 out |
| Thursday, July 18 |
| » Defeated Brewers (37-48), 5-2 | County Stadium (2-1) | 43-45 | |
| » W: Mike Moore (8-5) L: Danny Darwin (6-10) | Fifth | 9 out |
| Friday, July 19 |
| » Lost to Brewers (38-48), 9-7 | County Stadium (2-2) | 43-46 | |
| » W: Teddy Higuera (7-5) L: Matt Young (7-10) S: Bob Gibson (6) | Fifth | 10 out |
| Saturday, July 20 |
| » Defeated Brewers (38-49), 13-10 | County Stadium (3-2) | 44-46 | |
| » W: Ed Vande Berg (1-1) L: Bob McClure (2-1) S: Roy Thomas (1) | Fifth | 10 out |
| Sunday, July 21 |
| » Lost to Brewers (39-49), 5-4 | County Stadium (3-3) | 44-47 | |
| » W: Ray Burris (5-7) L: Frank Wills (4-4) S: Bob Gibson (7) | Fifth | 10 out |
| Monday, July 22 |
| » Lost to Blue Jays (56-37), 3-1 | Exhibition Stadium (0-4) | 44-48 | Lost 2 |
| » W: Tom Filer (1-0) L: Mark Langston (5-7) S: Bill Caudill (12) | Fifth | 10 out |
| Tuesday, July 23 |
| » Lost to Blue Jays (57-37), 4-2 | Exhibition Stadium (0-5) | 44-49 | Lost 3 |
| » W: Doyle Alexander (9-6) L: Mike Moore (8-6) S: Bill Caudill (13) | Sixth | 11 out |
| Wednesday, July 24 |
| » Lost to Blue Jays (58-37), 3-1 | Exhibition Stadium (0-6) | 44-50 | Lost 4 |
| » W: Jimmy Key (9-4) L: Matt Young (7-11) S: Gary Lavelle (5) | Fifth | 12 out |
| Thursday, July 25 |
| » Lost to Red Sox (51-44), 5-3 | Fenway Park (2-1) | 44-51 | Lost 5 |
| » W: Bob Ojeda (5-6) L: Bill Swift (3-4) S: Mark Clear (2) | Fifth | 12 out |
| Friday, July 26 |
| » Lost to Red Sox (52-44), 6-2 | Fenway Park (2-2) | 44-52 | Lost 6 |
| » W: Al Nipper (7-6) L: Jim Beattie (3-5) S: Bob Stanley (10) | Sixth | 12 out |
| Saturday, July 27 |
| » Defeated Red Sox (52-45), 10-3 | Fenway Park (3-2) | 45-52 | |
| » W: Roy Thomas (5-0) L: Tim Lollar (4-6) | Sixth | 11 out |
| Sunday, July 28 |
| » Defeated Red Sox (52-46), 7-2 | Fenway Park (4-2) | 46-52 | Won 2 |
| » W: Mike Moore (9-6) L: Bruce Hurst (7-8) | Sixth | 10 out |
| Monday, July 29 |
| » Defeated Twins (45-52), 8-6 | Kingdome (28-24) | 47-52 | Won 3 |
| » W: Edwin Nunez (5-1) L: Frank Eufemia (3-1) | Fifth | 9½ out |
| Tuesday, July 30 |
| » Lost to Twins (46-52), 12-4 | Kingdome (28-25) | 47-53 | |
| » W: Mike Smithson (11-7) L: Bill Swift (3-5) | Fifth | 9½ out |
| Wednesday, July 31 |
| » Defeated Twins (46-53), 12-3 | Kingdome (29-25) | 48-53 | |
| » W: Jim Beattie (4-5) L: John Butcher (8-10) S: Frank Wills (1) | Fifth | 9½ out |
| Friday, August 2 |
| » Lost to Athletics (54-48), 3-1 | Oakland-Alameda County Stadium (0-4) | 48-54 | |
| » W: Rick Langford (1-4) L: Mark Langston (5-8) S: Steve Ontiveros (3) | Fifth | 10 out |
| Saturday, August 3 |
| » Defeated Athletics (54-49), 6-2 | Oakland-Alameda County Stadium (1-4) | 49-54 | |
| » W: Mike Moore (10-6) L: Bill Krueger (8-10) | Fifth | 10 out |
| Sunday, August 4 |
| » Lost to Athletics (55-49), 5-3 | Oakland-Alameda County Stadium (1-5) | 49-55 | |
| » W: Don Sutton (10-6) L: Matt Young (7-12) S: Jay Howell (22) | Fifth | 11 out |
| Monday, August 5 |
| » Lost to Angels (61-44), 3-1 | Anaheim Stadium (1-3) | 49-56 | Lost 2 |
| » W: Mike Witt (9-7) L: Bill Swift (3-6) | Fifth | 12 out |
| Thursday, August 8 |
| » Lost to Athletics (57-49), 11-2 | Kingdome (29-26) | 49-57 | Lost 3 |
| » W: Chris Codiroli (10-8) L: Mark Langston (5-9) | Fifth | 12 out |
| Friday, August 9 |
| » Lost to Athletics (58-49), 6-4 | Kingdome (29-27) | 49-58 | Lost 4 |
| » W: Don Sutton (11-6) L: Mike Moore (10-7) S: Steve Ontiveros (4) | Fifth | 12 out |
| Saturday, August 10 |
| » Lost to Athletics (59-49), 11-5 | Kingdome (29-28) | 49-59 | Lost 5 |
| » W: Tim Birtsas (9-2) L: Matt Young (7-13) | Fifth | 13 out |
| Sunday, August 11 |
| » Defeated Athletics (59-50), 9-6 | Kingdome (30-28) | 50-59 | |
| » W: Bill Swift (4-6) L: Rick Langford (1-5) S: Edwin Nunez (13) | Fifth | 13 out |
| Monday, August 12 |
| » Defeated Angels (63-47), 6-5 | Kingdome (31-28) | 51-59 | Won 2 |
| » W: Edwin Nunez (6-1) L: Donnie Moore (7-5) | Sixth | 13 out |
| » Lost to Angels (64-47), 4-3 | Kingdome (31-29) | 51-60 | |
| » W: Jim Slaton (5-9) L: Jim Lewis (0-1) S: Luis Sanchez (1) | Sixth | 13 out |
| Tuesday, August 13 |
| » Defeated Angels (64-48), 11-4 | Kingdome (32-29) | 52-60 | |
| » W: Mark Langston (6-9) L: Ron Romanick (13-6) | Sixth | 12 out |
| Wednesday, August 14 |
| » Lost to Angels (65-48), 3-1 | Kingdome (32-30) | 52-61 | |
| » W: Stew Cliburn (7-2) L: Edwin Nunez (6-2) S: Donnie Moore (22) | Fifth | 12 out |
| » Defeated Angels (65-49), 6-1 | Kingdome (33-30) | 53-61 | |
| » W: Jim Beattie (5-5) L: Geoff Zahn (2-2) S: Jack Lazorko (1) | Fifth | 12 out |
| Thursday, August 15 |
| » Lost to Twins (52-61), 14-5 | Hubert H. Humphrey Metrodome (0-4) | 53-62 | |
| » W: John Butcher (9-11) L: Matt Young (7-14) | Fifth | 12½ out |
| Friday, August 16 |
| » Defeated Twins (52-62), 6-5 | Hubert H. Humphrey Metrodome (1-4) | 54-62 | |
| » W: Ed Vande Berg (2-1) L: Steve Howe (2-2) S: Edwin Nunez (14) | Fifth | 12½ out |
| Saturday, August 17 |
| » Lost to Twins (53-62), 2-0 | Hubert H. Humphrey Metrodome (1-5) | 54-63 | |
| » W: Bert Blyleven (12-12) L: Frank Wills (4-5) | Fifth | 13½ out |
| Sunday, August 18 |
| » Defeated Twins (53-63), 7-2 | Hubert H. Humphrey Metrodome (2-5) | 55-63 | |
| » W: Mark Langston (7-9) L: Frank Viola (12-10) | Fifth | 12½ out |
| Tuesday, August 20 |
| » Defeated Orioles (61-55), 4-3 | Kingdome (34-30) | 56-63 | Won 2 |
| » W: Mike Moore (11-7) L: Nate Snell (3-2) | Fifth | 12 out |
| Wednesday, August 21 |
| » Lost to Orioles (62-55), 11-8 | Kingdome (34-31) | 56-64 | |
| » W: Dennis Martinez (10-7) L: Jim Beattie (5-6) S: Don Aase (8) | Fifth | 12 out |
| Thursday, August 22 |
| » Defeated Orioles (62-56), 4-0 | Kingdome (35-31) | 57-64 | |
| » W: Matt Young (8-14) L: Scott McGregor (10-11) | Fifth | 12 out |
| Friday, August 23 |
| » Lost to Yankees (71-49), 3-1 | Kingdome (35-32) | 57-65 | |
| » W: Phil Niekro (12-9) L: Bill Swift (4-7) S: Neil Allen (3) | Fifth | 13 out |
| Saturday, August 24 |
| » Lost to Yankees (72-49), 4-3 | Kingdome (35-33) | 57-66 | Lost 2 |
| » W: Marty Bystrom (3-1) L: Mark Langston (7-10) S: Brian Fisher (8) | Fifth | 13 out |
| Sunday, August 25 |
| » Lost to Yankees (73-49), 8-5 | Kingdome (35-34) | 57-67 | Lost 3 |
| » W: Ed Whitson (8-7) L: Mike Moore (11-8) S: Brian Fisher (9) | Fifth | 14 out |
| Monday, August 26 |
| » Lost to Tigers (67-57), 6-3 | Kingdome (35-35) | 57-68 | Lost 4 |
| » W: Juan Berenguer (3-3) L: Frank Wills (4-6) S: Willie Hernandez (27) | Fifth | 14 out |
| Tuesday, August 27 |
| » Defeated Tigers (67-58), 3-1 | Kingdome (36-35) | 58-68 | |
| » W: Matt Young (9-14) L: Frank Tanana (7-12) | Fifth | 14 out |
| Thursday, August 29 |
| » Lost to Orioles (66-58), 7-0 | Memorial Stadium (1-2) | 58-69 | |
| » W: Mike Boddicker (12-13) L: Bill Swift (4-8) | Fifth | 14 out |
| Friday, August 30 |
| » Lost to Orioles (67-58), 6-0 | Memorial Stadium (1-3) | 58-70 | Lost 2 |
| » W: Storm Davis (8-7) L: Mark Langston (7-11) | Fifth | 15 out |
| Saturday, August 31 |
| » Defeated Orioles (67-59), 6-0 | Memorial Stadium (2-3) | 59-70 | |
| » W: Mike Moore (12-8) L: Mike Flanagan (2-4) | Sixth | 14 out |
| Sunday, September 1 |
| » Defeated Orioles (67-60), 10-2 | Memorial Stadium (3-3) | 60-70 | Won 2 |
| » W: Matt Young (10-14) L: Dennis Martinez (11-8) | Fifth | 13 out |
| Monday, September 2 |
| » Lost to Yankees (77-52), 8-7 | Yankee Stadium (1-3) | 60-71 | |
| » W: Ron Guidry (17-5) L: Frank Wills (4-7) S: Dave Righetti (24) | Fifth | 14 out |
| Tuesday, September 3 |
| » Lost to Yankees (78-52), 6-3 | Yankee Stadium (1-4) | 60-72 | Lost 2 |
| » W: Phil Niekro (14-9) L: Bill Swift (4-9) S: Dave Righetti (25) | Sixth | 14 out |
| Wednesday, September 4 |
| » Lost to Yankees (79-52), 4-3 | Yankee Stadium (1-5) | 60-73 | Lost 3 |
| » W: Rich Bordi (5-5) L: Mark Langston (7-12) S: Bob Shirley (1) | Sixth | 15 out |
| Friday, September 6 |
| » Defeated Tigers (71-62), 8-4 | Tiger Stadium (3-1) | 61-73 | |
| » W: Mike Moore (13-8) L: Walt Terrell (13-8) | Fifth | 14½ out |
| Saturday, September 7 |
| » Defeated Tigers (71-63), 12-5 | Tiger Stadium (4-1) | 62-73 | Won 2 |
| » W: Matt Young (11-14) L: Juan Berenguer (4-4) | Fifth | 14½ out |
| Sunday, September 8 |
| » Defeated Tigers (71-64), 6-2 | Tiger Stadium (5-1) | 63-73 | Won 3 |
| » W: Roy Thomas (6-0) L: Frank Tanana (7-14) | Fifth | 14½ out |
| Monday, September 9 |
| » Defeated Indians (49-89), 8-7 | Kingdome (37-35) | 64-73 | Won 4 |
| » W: Dave Tobik (1-0) L: Rich Thompson (3-7) | Fifth | 13½ out |
| Tuesday, September 10 |
| » Lost to Indians (50-89), 8-5 | Kingdome (37-36) | 64-74 | |
| » W: Bryan Clark (3-3) L: Frank Wills (4-8) S: Jerry Reed (5) | Fifth | 14½ out |
| Wednesday, September 11 |
| » Defeated Indians (50-90), 9-5 | Kingdome (38-36) | 65-74 | |
| » W: Mike Moore (14-8) L: Roy Smith (1-3) | Fifth | 14½ out |
| Friday, September 13 |
| » Lost to White Sox (72-68), 6-1 | Kingdome (38-37) | 65-75 | |
| » W: Jerry Don Gleaton (1-0) L: Matt Young (11-15) | Fifth | 15½ out |
| Saturday, September 14 |
| » Defeated White Sox (72-69), 6-5 | Kingdome (39-37) | 66-75 | |
| » W: Bill Swift (5-9) L: Floyd Bannister (6-14) S: Edwin Nunez (15) | Fifth | 15½ out |
| Sunday, September 15 |
| » Lost to White Sox (73-69), 6-3 | Kingdome (39-38) | 66-76 | |
| » W: Dave Wehrmeister (2-1) L: Mark Langston (7-13) S: Bob James (27) | Fifth | 16 out |
| Monday, September 16 |
| » Defeated Royals (82-61), 5-1 | Royals Stadium (3-0) | 67-76 | |
| » W: Mike Moore (15-8) L: Danny Jackson (13-10) | Fifth | 15 out |
| Tuesday, September 17 |
| » Defeated Royals (82-62), 7-0 | Royals Stadium (4-0) | 68-76 | Won 2 |
| » W: Matt Young (12-15) L: Steve Farr (2-1) | Fifth | 14 out |
| Wednesday, September 18 |
| » Defeated Royals (82-63), 6-0 | Royals Stadium (5-0) | 69-76 | Won 3 |
| » W: Roy Thomas (7-0) L: Mark Gubicza (13-8) | Fifth | 13 out |
| Thursday, September 19 |
| » Defeated Royals (82-64), 6-4 | Royals Stadium (6-0) | 70-76 | Won 4 |
| » W: Edwin Nunez (7-2) L: Dan Quisenberry (7-9) S: Dave Tobik (1) | Fourth | 12 out |
| Friday, September 20 |
| » Lost to Rangers (53-93), 10-9 | Arlington Stadium (1-3) | 70-77 | |
| » W: Dwayne Henry (2-2) L: Edwin Nunez (7-3) | Fourth | 13 out |
| Saturday, September 21 |
| » Lost to Rangers (54-93), 7-2 | Arlington Stadium (1-4) | 70-78 | Lost 2 |
| » W: Jose Guzman (1-2) L: Matt Young (12-16) S: Greg Harris (11) | Fourth | 14 out |
| Sunday, September 22 |
| » Lost to Rangers (55-93), 6-0 | Arlington Stadium (1-5) | 70-79 | Lost 3 |
| » W: Mike Mason (8-13) L: Frank Wills (4-9) | Fifth | 15 out |
| Monday, September 23 |
| » Lost to Rangers (56-93), 11-4 | Arlington Stadium (1-6) | 70-80 | Lost 4 |
| » W: Dave Schmidt (6-5) L: Mark Langston (7-14) S: Dave Rozema (7) | Fifth | 15 out |
| Tuesday, September 24 |
| » Defeated Royals (84-66), 5-2 | Kingdome (40-38) | 71-80 | |
| » W: Mike Moore (16-8) L: Mark Gubicza (13-9) | Fifth | 14 out |
| Wednesday, September 25 |
| » Lost to Royals (85-66), 5-4 | Kingdome (40-39) | 71-81 | |
| » W: Bret Saberhagen (19-6) L: Matt Young (12-17) S: Steve Farr (1) | Fifth | 15 out |
| Thursday, September 26 |
| » Lost to Royals (86-66), 5-2 | Kingdome (40-40) | 71-82 | Lost 2 |
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