| Monday, January 28 |
| Former Indian Bobby Young dies in Baltimore, MD at the age of 61. |
| Tuesday, February 26 |
| Former Indian George Uhle dies in Lakewood, OH at the age of 87. |
| Friday, March 1 |
| Former Indian George Banks dies in Spartanburg, SC at the age of 47. |
| Sunday, March 10 |
| Former Indian Bob Nieman dies in Corona, CA at the age of 59. |
| Monday, April 8 |
| » Lost to Tigers (1-0), 5-4 | Tiger Stadium (0-1) | 0-1 | |
| » W: Jack Morris (1-0) L: Ernie Camacho (0-1) S: Willie Hernandez (1) | Third | 1 out |
| » Major-league debuts: Chris Pittaro (Tigers) |
| Wednesday, April 10 |
| » Lost to Tigers (2-0), 8-1 | Tiger Stadium (0-2) | 0-2 | Lost 2 |
| » W: Dan Petry (1-0) L: Vern Ruhle (0-1) S: Aurelio Lopez (1) | Fourth | 2 out |
| » Major-league debuts: Jim Weaver (Tigers) |
| Thursday, April 11 |
| » Lost to Tigers (3-0), 11-10 | Tiger Stadium (0-3) | 0-3 | Lost 3 |
| » W: Willie Hernandez (1-0) L: Dave VonOhlen (0-1) | Fifth | 3 out |
| Saturday, April 13 |
| » Lost to Yankees (1-3), 6-3 | Cleveland Stadium (0-1) | 0-4 | Lost 4 |
| » W: Ron Guidry (1-0) L: Bert Blyleven (0-1) S: Dave Righetti (1) | Fifth | 4 out |
| Sunday, April 14 |
| » Lost to Yankees (2-3), 2-1 | Cleveland Stadium (0-2) | 0-5 | Lost 5 |
| » W: Phil Niekro (1-1) L: Tom Waddell (0-1) S: Dave Righetti (2) | Fifth | 5 out |
| Monday, April 15 |
| » Major-league debuts: Steve Lyons (Red Sox) |
| Tuesday, April 16 |
| » Defeated Orioles (4-2), 6-3 | Cleveland Stadium (1-2) | 1-5 | |
| » W: Vern Ruhle (1-1) L: Dennis Martinez (0-1) S: Tom Waddell (1) | Sixth | 5 out |
| Wednesday, April 17 |
| » Lost to Orioles (5-2), 6-3 | Cleveland Stadium (1-3) | 1-6 | |
| » W: Sammy Stewart (1-0) L: Jose Roman (0-1) | Fifth | 5 out |
| Thursday, April 18 |
| » Defeated Orioles (5-3), 11-5 | Cleveland Stadium (2-3) | 2-6 | |
| » W: Dave VonOhlen (1-1) L: Nate Snell (0-1) | Sixth | 4½ out |
| Friday, April 19 |
| » Defeated Yankees (4-4), 2-1 | Yankee Stadium (1-0) | 3-6 | Won 2 |
| » W: Neal Heaton (1-0) L: Ron Guidry (1-1) S: Tom Waddell (2) | Seventh | 3½ out |
| Saturday, April 20 |
| » Lost to Yankees (5-4), 5-2 | Yankee Stadium (1-1) | 3-7 | |
| » W: Phil Niekro (2-1) L: Jose Roman (0-2) S: Dave Righetti (4) | Sixth | 4½ out |
| Sunday, April 21 |
| » Defeated Yankees (5-5), 3-0 | Yankee Stadium (2-1) | 4-7 | |
| » W: Dave VonOhlen (2-1) L: Ed Whitson (0-2) S: Tom Waddell (3) | Sixth | 3½ out |
| Monday, April 22 |
| » Defeated Tigers (7-4), 6-4 | Cleveland Stadium (3-3) | 5-7 | Won 2 |
| » W: Don Schulze (1-0) L: Jack Morris (2-2) S: Tom Waddell (4) | Sixth | 2½ out |
| Tuesday, April 23 |
| » Lost to Tigers (8-4), 4-3 | Cleveland Stadium (3-4) | 5-8 | |
| » W: Dan Petry (3-1) L: Bert Blyleven (0-2) S: Willie Hernandez (3) | Sixth | 3½ out |
| Wednesday, April 24 |
| » Defeated Tigers (8-5), 7-6 | Cleveland Stadium (4-4) | 6-8 | |
| » W: Jamie Easterly (1-0) L: Aurelio Lopez (0-1) | Fifth | 2½ out |
| Thursday, April 25 |
| » Lost to Orioles (9-6), 7-1 | Memorial Stadium (0-1) | 6-9 | |
| » W: Ken Dixon (1-0) L: Jose Roman (0-3) | Fifth | 3 out |
| Friday, April 26 |
| » Lost to Orioles (10-6), 6-3 | Memorial Stadium (0-2) | 6-10 | Lost 2 |
| » W: Dennis Martinez (2-1) L: Vern Ruhle (1-2) S: Sammy Stewart (3) | Sixth | 4 out |
| Saturday, April 27 |
| » Defeated Orioles (10-7), 10-4 | Memorial Stadium (1-2) | 7-10 | |
| » W: Don Schulze (2-0) L: Scott McGregor (1-2) | Fifth | 3½ out |
| Sunday, April 28 |
| » Lost to Orioles (11-7), 8-7 | Memorial Stadium (1-3) | 7-11 | |
| » W: Don Aase (2-0) L: Tom Waddell (0-2) | Fifth | 4½ out |
| Monday, April 29 |
| » Lost to Royals (10-8), 3-2 | Royals Stadium (0-1) | 7-12 | Lost 2 |
| » W: Bud Black (2-1) L: Neal Heaton (1-1) S: Dan Quisenberry (3) | Sixth | 5 out |
| Tuesday, April 30 |
| » Lost to Royals (11-8), 5-1 | Royals Stadium (0-2) | 7-13 | Lost 3 |
| » W: Bret Saberhagen (2-2) L: Jose Roman (0-4) | Sixth | 6 out |
| Wednesday, May 1 |
| » Defeated Royals (11-9), 6-5 | Royals Stadium (1-2) | 8-13 | |
| » W: Don Schulze (3-0) L: Mark Gubicza (0-2) S: Tom Waddell (5) | Sixth | 6 out |
| Friday, May 3 |
| » Defeated Rangers (7-14), 4-0 | Cleveland Stadium (5-4) | 9-13 | Won 2 |
| » W: Bert Blyleven (1-2) L: Mike Mason (2-3) | Sixth | 5½ out |
| Saturday, May 4 |
| » Defeated Rangers (7-15), 3-1 | Cleveland Stadium (6-4) | 10-13 | Won 3 |
| » W: Neal Heaton (2-1) L: Frank Tanana (0-4) S: Tom Waddell (6) | Fifth | 4½ out |
| Sunday, May 5 |
| » Lost to Rangers (8-15), 7-2 | Cleveland Stadium (6-5) | 10-14 | |
| » W: Charlie Hough (2-1) L: Don Schulze (3-1) S: Greg Harris (1) | Sixth | 5½ out |
| Tuesday, May 7 |
| » Lost to White Sox (11-11), 7-4 | Cleveland Stadium (6-6) | 10-15 | Lost 2 |
| » W: Floyd Bannister (1-3) L: Bert Blyleven (1-3) S: Bob James (3) | Seventh | 6½ out |
| Wednesday, May 8 |
| » Lost to White Sox (12-11), 4-0 | Cleveland Stadium (6-7) | 10-16 | Lost 3 |
| » W: Britt Burns (4-2) L: Neal Heaton (2-2) | Seventh | 6½ out |
| Friday, May 10 |
| » Lost to Rangers (9-17), 5-2 | Arlington Stadium (0-1) | 10-17 | Lost 4 |
| » W: Charlie Hough (3-1) L: Don Schulze (3-2) S: Dave Rozema (2) | Seventh | 7½ out |
| Saturday, May 11 |
| » Defeated Rangers (9-18), 4-1 | Arlington Stadium (1-1) | 11-17 | |
| » W: Tom Waddell (1-2) L: Greg Harris (0-1) | Sixth | 7½ out |
| Sunday, May 12 |
| » Defeated Rangers (9-19), 6-0 | Arlington Stadium (2-1) | 12-17 | Won 2 |
| » W: Bert Blyleven (2-3) L: Dickie Noles (2-3) | Sixth | 6½ out |
| Monday, May 13 |
| » Lost to White Sox (15-12), 8-0 | Comiskey Park I (0-1) | 12-18 | |
| » W: Britt Burns (5-2) L: Neal Heaton (2-3) | Seventh | 7 out |
| Tuesday, May 14 |
| » Lost to White Sox (16-12), 2-1 | Comiskey Park I (0-2) | 12-19 | Lost 2 |
| » W: Gene Nelson (2-1) L: Rich Thompson (0-1) S: Bob James (5) | Seventh | 8 out |
| Wednesday, May 15 |
| » Lost to Royals (16-15), 5-1 | Cleveland Stadium (6-8) | 12-20 | Lost 3 |
| » W: Charlie Leibrandt (4-2) L: Don Schulze (3-3) | Seventh | 8 out |
| Thursday, May 16 |
| » Lost to Royals (17-15), 7-1 | Cleveland Stadium (6-9) | 12-21 | Lost 4 |
| » W: Bud Black (3-3) L: Keith Creel (0-1) | Seventh | 8½ out |
| Former Indian Johnny Broaca dies in Lawrence, MA at the age of 76. |
| Friday, May 17 |
| » Lost to Red Sox (16-17), 5-0 | Cleveland Stadium (6-10) | 12-22 | Lost 5 |
| » W: Roger Clemens (4-4) L: Bert Blyleven (2-4) | Sixth | 8½ out |
| Saturday, May 18 |
| » Defeated Red Sox (16-18), 4-1 | Cleveland Stadium (7-10) | 13-22 | |
| » W: Neal Heaton (3-3) L: Bruce Hurst (1-4) S: Tom Waddell (7) | Seventh | 8½ out |
| Sunday, May 19 |
| » Defeated Red Sox (16-19), 2-1 | Cleveland Stadium (8-10) | 14-22 | Won 2 |
| » W: Rich Thompson (1-1) L: Oil Can Boyd (4-3) | Sixth | 7½ out |
| Monday, May 20 |
| » Major-league debuts: Jack Howell (Angels) |
| Tuesday, May 21 |
| » Defeated Brewers (14-21), 6-4 | Cleveland Stadium (9-10) | 15-22 | Won 3 |
| » W: Bryan Clark (1-0) L: Teddy Higuera (1-3) S: Rich Thompson (1) | Sixth | 8 out |
| Wednesday, May 22 |
| » Lost to Brewers (15-21), 6-5 | Cleveland Stadium (9-11) | 15-23 | |
| » W: Bob Gibson (5-1) L: Bert Blyleven (2-5) S: Rollie Fingers (4) | Seventh | 9 out |
| Thursday, May 23 |
| » Lost to Blue Jays (25-14), 6-5 | Cleveland Stadium (9-12) | 15-24 | Lost 2 |
| » W: Dennis Lamp (3-0) L: Tom Waddell (1-3) S: Bill Caudill (8) | Seventh | 10 out |
| Friday, May 24 |
| » Lost to Blue Jays (26-14), 7-6 | Cleveland Stadium (9-13) | 15-25 | Lost 3 |
| » W: Dennis Lamp (4-0) L: Keith Creel (0-2) S: Gary Lavelle (3) | Seventh | 11 out |
| Saturday, May 25 |
| » Lost to Blue Jays (27-14), 10-7 | Cleveland Stadium (9-14) | 15-26 | Lost 4 |
| » W: Ron Musselman (2-0) L: Rich Thompson (1-2) S: Jim Acker (6) | Seventh | 12 out |
| Sunday, May 26 |
| » Lost to Blue Jays (28-14), 6-5 | Cleveland Stadium (9-15) | 15-27 | Lost 5 |
| » W: Gary Lavelle (2-0) L: Keith Creel (0-3) S: Bill Caudill (9) | Seventh | 13 out |
| Monday, May 27 |
| » Defeated Brewers (18-22), 8-0 | County Stadium (1-0) | 16-27 | |
| » W: Bert Blyleven (3-5) L: Danny Darwin (3-4) | Seventh | 12½ out |
| Tuesday, May 28 |
| » Lost to Brewers (19-22), 3-2 | County Stadium (1-1) | 16-28 | |
| » W: Moose Haas (5-2) L: Neal Heaton (3-4) S: Rollie Fingers (7) | Seventh | 13½ out |
| Wednesday, May 29 |
| » Lost to Brewers (20-22), 7-2 | County Stadium (1-2) | 16-29 | Lost 2 |
| » W: Ray Burris (3-4) L: Don Schulze (3-4) S: Bob Gibson (2) | Seventh | 13½ out |
| Friday, May 31 |
| » Lost to Blue Jays (30-15), 7-2 | Exhibition Stadium (0-1) | 16-30 | Lost 3 |
| » W: Doyle Alexander (6-2) L: Bryan Clark (1-1) S: Jim Acker (7) | Seventh | 14½ out |
| Saturday, June 1 |
| » Lost to Blue Jays (31-15), 8-3 | Exhibition Stadium (0-2) | 16-31 | Lost 4 |
| » W: Jimmy Key (4-2) L: Bert Blyleven (3-6) | Sixth | 15½ out |
| Sunday, June 2 |
| » Defeated Blue Jays (31-16), 5-4 | Exhibition Stadium (1-2) | 17-31 | |
| » W: Neal Heaton (4-4) L: Dave Stieb (5-4) S: Tom Waddell (8) | Seventh | 15½ out |
| » Lost to Blue Jays (32-16), 5-2 | Exhibition Stadium (1-3) | 17-32 | |
| » W: Luis Leal (3-3) L: Rick Behenna (0-1) S: Jim Acker (8) | Seventh | 15½ out |
| Monday, June 3 |
| » Lost to Red Sox (24-25), 6-5 | Fenway Park (0-1) | 17-33 | Lost 2 |
| » W: Oil Can Boyd (6-4) L: Don Schulze (3-5) | Sixth | 16 out |
| Tuesday, June 4 |
| » Lost to Red Sox (25-25), 5-0 | Fenway Park (0-2) | 17-34 | Lost 3 |
| » W: Bob Ojeda (3-1) L: Keith Creel (0-4) | Sixth | 17 out |
| Thursday, June 6 |
| » Defeated Mariners (23-29), 9-1 | Cleveland Stadium (10-15) | 18-34 | |
| » W: Bert Blyleven (4-6) L: Matt Young (4-7) | Seventh | 17½ out |
| Friday, June 7 |
| » Lost to Mariners (24-29), 6-4 | Cleveland Stadium (10-16) | 18-35 | |
| » W: Bill Swift (1-0) L: Neal Heaton (4-5) S: Ed Vande Berg (2) | Seventh | 18½ out |
| » Major-league debuts: Bill Swift (Mariners) |
| Saturday, June 8 |
| » Defeated Mariners (24-30), 12-8 | Cleveland Stadium (11-16) | 19-35 | |
| » W: Tom Waddell (2-3) L: Mike Stanton (1-2) | Seventh | 17½ out |
| Sunday, June 9 |
| » Lost to Mariners (25-30), 10-6 | Cleveland Stadium (11-17) | 19-36 | |
| » W: Frank Wills (1-0) L: Don Schulze (3-6) S: Edwin Nunez (6) | Sixth | 17½ out |
| Monday, June 10 |
| » Lost to Twins (24-30), 6-4 | Cleveland Stadium (11-18) | 19-37 | Lost 2 |
| » W: Frank Viola (7-5) L: Keith Creel (0-5) S: Ron Davis (6) | Sixth | 17½ out |
| Friday, June 14 |
| » Defeated Athletics (28-30), 6-1 | Cleveland Stadium (12-18) | 20-37 | |
| » W: Bert Blyleven (5-6) L: Bill Krueger (4-7) | Seventh | 17 out |
| Saturday, June 15 |
| » Lost to Athletics (29-30), 8-6 | Cleveland Stadium (12-19) | 20-38 | |
| » W: Tim Birtsas (3-1) L: Neal Heaton (4-6) S: Jay Howell (13) | Seventh | 17 out |
| Sunday, June 16 |
| » Lost to Athletics (30-30), 3-2 | Cleveland Stadium (12-20) | 20-39 | Lost 2 |
| » W: Don Sutton (5-5) L: Tom Waddell (2-4) S: Jay Howell (14) | Seventh | 17½ out |
| » Lost to Athletics (31-30), 11-6 | Cleveland Stadium (12-21) | 20-40 | Lost 3 |
| » W: Steve McCatty (3-3) L: Vern Ruhle (1-3) | Seventh | 17½ out |
| Tuesday, June 18 |
| » Lost to Angels (34-28), 7-3 | Cleveland Stadium (12-22) | 20-41 | Lost 4 |
| » W: Mike Witt (5-6) L: Neal Heaton (4-7) | Seventh | 17 out |
| Wednesday, June 19 |
| » Defeated Angels (34-29), 2-0 | Cleveland Stadium (13-22) | 21-41 | |
| » W: Bert Blyleven (6-6) L: Jim Slaton (4-5) | Seventh | 17 out |
| Thursday, June 20 |
| » Lost to Angels (35-29), 4-0 | Cleveland Stadium (13-23) | 21-42 | |
| » W: Ron Romanick (8-3) L: Don Schulze (3-7) | Seventh | 18 out |
| Friday, June 21 |
| » Lost to Athletics (33-32), 9-1 | Oakland-Alameda County Stadium (0-1) | 21-43 | Lost 2 |
| » W: Don Sutton (6-5) L: Rick Behenna (0-2) | Seventh | 19 out |
| Saturday, June 22 |
| » Lost to Athletics (34-32), 6-4 | Oakland-Alameda County Stadium (0-2) | 21-44 | Lost 3 |
| » W: Jay Howell (7-3) L: Jeff Barkley (0-1) | Seventh | 19 out |
| Sunday, June 23 |
| » Lost to Athletics (35-32), 9-3 | Oakland-Alameda County Stadium (0-3) | 21-45 | Lost 4 |
| » W: Chris Codiroli (8-3) L: Neal Heaton (4-8) | Seventh | 20 out |
| Monday, June 24 |
| » Defeated Angels (38-30), 2-1 | Anaheim Stadium (1-0) | 22-45 | |
| » W: Bert Blyleven (7-6) L: Jim Slaton (4-6) | Seventh | 19½ out |
| Tuesday, June 25 |
| » Lost to Angels (39-30), 7-3 | Anaheim Stadium (1-1) | 22-46 | |
| » W: Stew Cliburn (3-1) L: Neal Heaton (4-9) | Sixth | 20½ out |
| Wednesday, June 26 |
| » Lost to Angels (40-30), 10-6 | Anaheim Stadium (1-2) | 22-47 | Lost 2 |
| » W: Luis Sanchez (1-0) L: Jeff Barkley (0-2) | Seventh | 20½ out |
| Friday, June 28 |
| » Lost to Mariners (35-36), 8-6 | Kingdome (0-1) | 22-48 | Lost 3 |
| » W: Roy Thomas (3-0) L: Jeff Barkley (0-3) S: Edwin Nunez (10) | Seventh | 22 out |
| Saturday, June 29 |
| » Lost to Mariners (36-36), 3-2 | Kingdome (0-2) | 22-49 | Lost 4 |
| » W: Mike Moore (6-4) L: Bert Blyleven (7-7) S: Edwin Nunez (11) | Seventh | 22 out |
| Sunday, June 30 |
| » Defeated Mariners (36-37), 7-3 | Kingdome (1-2) | 23-49 | |
| » W: Rich Thompson (2-2) L: Matt Young (7-9) S: Tom Waddell (9) | Sixth | 22 out |
| Monday, July 1 |
| » Defeated Twins (33-39), 5-2 | Hubert H. Humphrey Metrodome (1-0) | 24-49 | Won 2 |
| » W: Vern Ruhle (2-3) L: Ken Schrom (7-6) S: Jeff Barkley (1) | Seventh | 21 out |
| Tuesday, July 2 |
| » Lost to Twins (34-39), 8-7 | Hubert H. Humphrey Metrodome (1-1) | 24-50 | |
| » W: Frank Eufemia (2-0) L: Tom Waddell (2-5) S: Pete Filson (2) | Seventh | 21 out |
| Wednesday, July 3 |
| » Lost to Twins (35-39), 7-0 | Hubert H. Humphrey Metrodome (1-2) | 24-51 | Lost 2 |
| » W: Mike Smithson (7-7) L: Neal Heaton (4-10) | Seventh | 22 out |
| Thursday, July 4 |
| » Lost to White Sox (37-37), 5-0 | Cleveland Stadium (13-24) | 24-52 | Lost 3 |
| » W: Britt Burns (8-6) L: Bert Blyleven (7-8) | Seventh | 22 out |
| Friday, July 5 |
| » Lost to White Sox (38-37), 8-3 | Cleveland Stadium (13-25) | 24-53 | Lost 4 |
| » W: Tom Seaver (8-6) L: Jerry Reed (0-1) | Seventh | 23 out |
| Saturday, July 6 |
| » Lost to White Sox (39-37), 6-4 | Cleveland Stadium (13-26) | 24-54 | Lost 5 |
| » W: Bob James (4-2) L: Rich Thompson (2-3) | Seventh | 23 out |
| Sunday, July 7 |
| » Defeated White Sox (39-38), 10-3 | Cleveland Stadium (14-26) | 25-54 | |
| » W: Tom Waddell (3-5) L: Tim Lollar (3-5) | Seventh | 23 out |
| Monday, July 8 |
| » Defeated Rangers (31-51), 4-0 | Cleveland Stadium (15-26) | 26-54 | Won 2 |
| » W: Neal Heaton (5-10) L: Mike Mason (5-8) | Seventh | 23 out |
| Tuesday, July 9 |
| » Defeated Rangers (31-52), 7-2 | Cleveland Stadium (16-26) | 27-54 | Won 3 |
| » W: Bert Blyleven (8-8) L: Burt Hooton (4-3) | Seventh | 23 out |
| Wednesday, July 10 |
| » Lost to Rangers (32-52), 4-1 | Cleveland Stadium (16-27) | 27-55 | |
| » W: Charlie Hough (7-10) L: Jerry Reed (0-2) | Seventh | 24 out |
| Thursday, July 11 |
| » Lost to Royals (42-41), 1-0 | Cleveland Stadium (16-28) | 27-56 | Lost 2 |
| » W: Danny Jackson (7-6) L: Vern Ruhle (2-4) | Seventh | 25 out |
| Friday, July 12 |
| » Defeated Royals (42-42), 5-4 | Cleveland Stadium (17-28) | 28-56 | |
| » W: Tom Waddell (4-5) L: Dan Quisenberry (4-6) | Sixth | 24 out |
| Saturday, July 13 |
| » Lost to Royals (43-42), 5-1 | Cleveland Stadium (17-29) | 28-57 | |
| » W: Bret Saberhagen (10-4) L: Bert Blyleven (8-9) | Seventh | 24 out |
| Sunday, July 14 |
| » Lost to Royals (44-42), 9-5 | Cleveland Stadium (17-30) | 28-58 | Lost 2 |
| » W: Bud Black (6-10) L: Neal Heaton (5-11) S: Dan Quisenberry (17) | Seventh | 24 out |
| Thursday, July 18 |
| » Lost to White Sox (43-42), 10-0 | Comiskey Park I (0-3) | 28-59 | Lost 3 |
| » W: Britt Burns (10-6) L: Vern Ruhle (2-5) | Seventh | 24 out |
| Friday, July 19 |
| » Lost to White Sox (44-42), 1-0 | Comiskey Park I (0-4) | 28-60 | Lost 4 |
| » W: Tom Seaver (10-7) L: Bert Blyleven (8-10) | Seventh | 25 out |
| Saturday, July 20 |
| » Lost to White Sox (45-42), 8-6 | Comiskey Park I (0-5) | 28-61 | Lost 5 |
| » W: Juan Agosto (1-1) L: Bryan Clark (1-2) | Seventh | 25 out |
| Sunday, July 21 |
| » Defeated White Sox (45-43), 4-3 | Comiskey Park I (1-5) | 29-61 | |
| » W: Rich Thompson (3-3) L: Dan Spillner (2-3) | Seventh | 25 out |
| » Major-league debuts: Bill Long (White Sox) |
| Monday, July 22 |
| » Lost to Rangers (36-57), 2-1 | Arlington Stadium (2-2) | 29-62 | |
| » W: Greg Harris (3-3) L: Vern Ruhle (2-6) | Seventh | 26 out |
| Tuesday, July 23 |
| » Lost to Rangers (37-57), 8-4 | Arlington Stadium (2-3) | 29-63 | Lost 2 |
| » W: Charlie Hough (9-10) L: Neal Heaton (5-12) S: Dave Rozema (6) | Seventh | 27 out |
| Wednesday, July 24 |
| » Defeated Rangers (37-58), 8-4 | Arlington Stadium (3-3) | 30-63 | |
| » W: Bert Blyleven (9-10) L: Burt Hooton (5-5) | Seventh | 27 out |
| Friday, July 26 |
| » Lost to Royals (50-44), 7-1 | Royals Stadium (1-3) | 30-64 | |
| » W: Danny Jackson (9-6) L: Ramon Romero (0-1) | Seventh | 28½ out |
| Saturday, July 27 |
| » Lost to Royals (51-44), 6-3 | Royals Stadium (1-4) | 30-65 | Lost 2 |
| » W: Bud Black (7-11) L: Jerry Reed (0-3) S: Dan Quisenberry (22) | Seventh | 29½ out |
| Former Indian Joe Wood dies in West Haven, CT at the age of 96. |
| Sunday, July 28 |
| » Lost to Royals (52-44), 7-4 | Royals Stadium (1-5) | 30-66 | Lost 3 |
| » W: Mark Gubicza (7-5) L: Vern Ruhle (2-7) S: Dan Quisenberry (23) | Seventh | 30½ out |
| Monday, July 29 |
| » Lost to Yankees (54-42), 8-2 | Cleveland Stadium (17-31) | 30-67 | Lost 4 |
| » W: Ed Whitson (6-7) L: Bert Blyleven (9-11) S: Dave Righetti (18) | Seventh | 31½ out |
| Tuesday, July 30 |
| » Lost to Yankees (55-42), 8-5 | Cleveland Stadium (17-32) | 30-68 | Lost 5 |
| » W: Joe Cowley (9-4) L: Rich Thompson (3-4) | Seventh | 31 out |
| » Defeated Yankees (55-43), 3-2 | Cleveland Stadium (18-32) | 31-68 | |
| » W: Ramon Romero (1-1) L: Bob Shirley (3-3) S: Rich Thompson (2) | Seventh | 31 out |
| Wednesday, July 31 |
| » Defeated Yankees (55-44), 6-5 | Cleveland Stadium (19-32) | 32-68 | Won 2 |
| » W: Tom Waddell (5-5) L: Ron Guidry (13-4) S: Rich Thompson (3) | Seventh | 31 out |
| Thursday, August 1 |
| » Defeated Yankees (55-45), 9-1 | Cleveland Stadium (20-32) | 33-68 | Won 3 |
| » W: Roy Smith (1-0) L: Phil Niekro (10-9) | Seventh | 31 out |
| Friday, August 2 |
| » Lost to Orioles (52-49), 8-6 | Cleveland Stadium (20-33) | 33-69 | |
| » W: Sammy Stewart (4-4) L: Rich Thompson (3-5) | Seventh | 32 out |
| Saturday, August 3 |
| » Defeated Orioles (52-50), 10-4 | Cleveland Stadium (21-33) | 34-69 | |
| » W: Curt Wardle (2-3) L: Mike Boddicker (10-12) | Seventh | 32 out |
| Sunday, August 4 |
| » Lost to Orioles (53-50), 5-4 | Cleveland Stadium (21-34) | 34-70 | |
| » W: Dennis Martinez (8-7) L: Rich Thompson (3-6) | Sixth | 32 out |
| Thursday, August 8 |
| » Lost to Yankees (58-47), 8-1 | Yankee Stadium (2-2) | 34-71 | Lost 2 |
| » W: Marty Bystrom (1-1) L: Curt Wardle (2-4) | Seventh | 34 out |
| » Lost to Yankees (59-47), 7-6 | Yankee Stadium (2-3) | 34-72 | Lost 3 |
| » W: Brian Fisher (3-2) L: Jerry Reed (0-4) S: Dave Righetti (20) | Seventh | 34 out |
| Friday, August 9 |
| » Defeated Tigers (57-50), 4-2 | Cleveland Stadium (22-34) | 35-72 | |
| » W: Jamie Easterly (2-0) L: Willie Hernandez (6-5) S: Rich Thompson (4) | Seventh | 33 out |
| Saturday, August 10 |
| » Lost to Tigers (58-50), 5-4 | Cleveland Stadium (22-35) | 35-73 | |
| » W: Willie Hernandez (7-5) L: Vern Ruhle (2-8) | Seventh | 33 out |
| Sunday, August 11 |
| » Defeated Tigers (58-51), 7-2 | Cleveland Stadium (23-35) | 36-73 | |
| » W: Neal Heaton (6-12) L: Randy O'Neal (5-5) | Seventh | 33 out |
| Monday, August 12 |
| » Defeated Orioles (55-54), 8-5 | Memorial Stadium (2-3) | 37-73 | Won 2 |
| » W: Curt Wardle (3-4) L: Scott McGregor (9-10) S: Jerry Reed (1) | Seventh | 32 out |
| Tuesday, August 13 |
| » Lost to Orioles (56-54), 8-4 | Memorial Stadium (2-4) | 37-74 | |
| » W: Don Aase (7-5) L: Vern Ruhle (2-9) | Seventh | 33 out |
| Wednesday, August 14 |
| » Lost to Orioles (57-54), 8-4 | Memorial Stadium (2-5) | 37-75 | Lost 2 |
| » W: Mike Flanagan (2-2) L: Bryan Clark (1-3) S: Nate Snell (5) | Seventh | 34 out |
| Thursday, August 15 |
| » Defeated Tigers (60-53), 7-6 | Tiger Stadium (1-3) | 38-75 | |
| » W: Curt Wardle (4-4) L: Willie Hernandez (7-7) S: Jerry Reed (2) | Seventh | 33½ out |
| Friday, August 16 |
| » Lost to Tigers (61-53), 3-2 | Tiger Stadium (1-4) | 38-76 | |
| » W: Aurelio Lopez (3-7) L: Neal Heaton (6-13) | Seventh | 33½ out |
| Saturday, August 17 |
| » Lost to Tigers (62-53), 7-5 | Tiger Stadium (1-5) | 38-77 | Lost 2 |
| » W: Frank Tanana (7-11) L: Curt Wardle (4-5) S: Randy O'Neal (1) | Seventh | 33½ out |
| Sunday, August 18 |
| » Lost to Tigers (63-53), 4-0 | Tiger Stadium (1-6) | 38-78 | Lost 3 |
| » W: Dan Petry (13-11) L: Ramon Romero (1-2) S: Willie Hernandez (25) | Seventh | 34½ out |
| Monday, August 19 |
| » Defeated Blue Jays (73-45), 5-3 | Cleveland Stadium (24-35) | 39-78 | |
| » W: Tom Waddell (6-5) L: Dave Stieb (11-9) | Seventh | 33½ out |
| Tuesday, August 20 |
| » Lost to Blue Jays (74-45), 3-2 | Cleveland Stadium (24-36) | 39-79 | |
| » W: Jimmy Key (10-5) L: Roy Smith (1-1) S: Tom Henke (4) | Seventh | 34½ out |
| Wednesday, August 21 |
| » Defeated Blue Jays (74-46), 5-2 | Cleveland Stadium (25-36) | 40-79 | |
| » W: Neal Heaton (7-13) L: Doyle Alexander (12-8) | Seventh | 33½ out |
| Thursday, August 22 |
| » Major-league debuts: Chuck Cary (Tigers) |
| Friday, August 23 |
| » Defeated Brewers (55-63), 10-5 | Cleveland Stadium (26-36) | 41-79 | Won 2 |
| » W: Curt Wardle (5-5) L: Jaime Cocanower (3-3) S: Vern Ruhle (1) | Seventh | 34 out |
| Sunday, August 25 |
| » Defeated Brewers (55-64), 6-2 | Cleveland Stadium (27-36) | 42-79 | Won 3 |
| » W: Tom Waddell (7-5) L: Moose Haas (7-6) | Seventh | 33 out |
| » Defeated Brewers (55-65), 2-0 | Cleveland Stadium (28-36) | 43-79 | Won 4 |
| » W: Ramon Romero (2-2) L: Danny Darwin (7-15) S: Bryan Clark (1) | Seventh | 33 out |
| Monday, August 26 |
| » Defeated Brewers (55-66), 4-3 | Cleveland Stadium (29-36) | 44-79 | Won 5 |
| » W: Neal Heaton (8-13) L: Bob Gibson (6-7) | Seventh | 33½ out |
| » Lost to Brewers (56-66), 8-3 | Cleveland Stadium (29-37) | 44-80 | |
| » W: Ray Burris (9-9) L: Roy Smith (1-2) S: Rollie Fingers (16) | Seventh | 33½ out |
| Tuesday, August 27 |
| » Defeated Red Sox (58-65), 6-2 | Cleveland Stadium (30-37) | 45-80 | |
| » W: Curt Wardle (6-5) L: Mike Trujillo (3-3) S: Vern Ruhle (2) | Seventh | 33½ out |
| Wednesday, August 28 |
| » Defeated Red Sox (58-66), 7-4 | Cleveland Stadium (31-37) | 46-80 | Won 2 |
| » W: Jamie Easterly (3-0) L: Tim Lollar (5-9) S: Jerry Reed (3) | Seventh | 32½ out |
| Thursday, August 29 |
| » Lost to Red Sox (59-66), 17-2 | Cleveland Stadium (31-38) | 46-81 | |
| » W: Bruce Hurst (9-10) L: Ramon Romero (2-3) | Seventh | 33 out |
| Friday, August 30 |
| » Lost to Brewers (58-67), 9-6 | County Stadium (1-3) | 46-82 | Lost 2 |
| » W: Moose Haas (8-6) L: Tom Waddell (7-6) | Seventh | 34 out |
| Saturday, August 31 |
| » Lost to Brewers (59-67), 10-8 | County Stadium (1-4) | 46-83 | Lost 3 |
| » W: Teddy Higuera (12-6) L: Neal Heaton (8-14) S: Bob Gibson (11) | Seventh | 35 out |
| Sunday, September 1 |
| » Defeated Brewers (59-68), 11-4 | County Stadium (2-4) | 47-83 | |
| » W: Dave VonOhlen (3-1) L: Ray Burris (9-10) | Seventh | 34 out |
| Monday, September 2 |
| » Lost to Blue Jays (82-49), 3-2 | Exhibition Stadium (1-4) | 47-84 | |
| » W: Dave Stieb (13-9) L: Curt Wardle (6-6) S: Tom Henke (9) | Seventh | 35 out |
| Wednesday, September 4 |
| » Defeated Blue Jays (82-50), 5-4 | Exhibition Stadium (2-4) | 48-84 | |
| » W: Bryan Clark (2-3) L: Tom Henke (3-2) S: Rich Thompson (5) | Seventh | 34 out |
| Thursday, September 5 |
| » Lost to Red Sox (64-68), 13-6 | Fenway Park (0-3) | 48-85 | |
| » W: Oil Can Boyd (12-11) L: Neal Heaton (8-15) | Seventh | 34½ out |
| » Defeated Red Sox (64-69), 9-5 | Fenway Park (1-3) | 49-85 | |
| » W: Jamie Easterly (4-0) L: Bob Ojeda (6-9) S: Jerry Reed (4) | Seventh | 34½ out |
| » Major-league debuts: Mike Greenwell Kevin Romine and Rob Woodward (Red Sox) |
| Saturday, September 7 |
| » Lost to Red Sox (65-69), 11-9 | Fenway Park (1-4) | 49-86 | |
| » W: Bruce Kison (4-3) L: Jerry Reed (0-5) S: Steve Crawford (7) | Seventh | 35½ out |
| » Lost to Red Sox (66-69), 7-4 | Fenway Park (1-5) | 49-87 | Lost 2 |
| » W: Al Nipper (8-10) L: Curt Wardle (6-7) S: Steve Crawford (8) | Seventh | 35½ out |
| Sunday, September 8 |
| » Lost to Red Sox (67-69), 8-1 | Fenway Park (1-6) | 49-88 | Lost 3 |
| » W: Tim Lollar (7-9) L: Neal Heaton (8-16) | Seventh | 36½ out |
| Monday, September 9 |
| » Lost to Mariners (64-73), 8-7 | Kingdome (1-3) | 49-89 | Lost 4 |
| » W: Dave Tobik (1-0) L: Rich Thompson (3-7) | Seventh | 37½ out |
| Tuesday, September 10 |
| » Defeated Mariners (64-74), 8-5 | Kingdome (2-3) | 50-89 | |
| » W: Bryan Clark (3-3) L: Frank Wills (4-8) S: Jerry Reed (5) | Seventh | 37½ out |
| Wednesday, September 11 |
| » Lost to Mariners (65-74), 9-5 | Kingdome (2-4) | 50-90 | |
| » W: Mike Moore (14-8) L: Roy Smith (1-3) | Seventh | 38½ out |
| Friday, September 13 |
| » Defeated Twins (62-78), 3-2 | Cleveland Stadium (32-38) | 51-90 | |
| » W: Curt Wardle (7-7) L: Mark Portugal (1-3) S: Jerry Reed (6) | Seventh | 38½ out |
| » Lost to Twins (63-78), 3-1 | Cleveland Stadium (32-39) | 51-91 | |
| » W: Frank Viola (14-14) L: Don Schulze (3-8) S: Ron Davis (20) | Seventh | 38½ out |
| » Major-league debuts: Jim Wilson (Indians) |
| Saturday, September 14 |
| » Defeated Twins (63-79), 11-9 | Cleveland Stadium (33-39) | 52-91 | |
| » W: Tom Waddell (8-6) L: John Butcher (10-13) S: Jerry Reed (7) | Seventh | 39 out |
| » Lost to Twins (64-79), 5-3 | Cleveland Stadium (33-40) | 52-92 | |
| » W: Dennis Burtt (1-1) L: Rich Thompson (3-8) S: Ron Davis (21) | Seventh | 39 out |
| Sunday, September 15 |
| » Lost to Twins (65-79), 5-2 | Cleveland Stadium (33-41) | 52-93 | Lost 2 |
| » W: Bert Blyleven (14-15) L: Roy Smith (1-4) S: Ron Davis (22) | Seventh | 40 out |
| Monday, September 16 |
| » Defeated Yankees (86-57), 9-5 | Yankee Stadium (3-3) | 53-93 | |
| » W: Jerry Reed (1-5) L: Brian Fisher (4-4) | Seventh | |