| Monday, April 8 |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Tuesday, April 9 |
| » Lost to White Sox (1-0), 4-2 | County Stadium (0-1) | 0-1 | |
| » W: Tom Seaver (1-0) L: Moose Haas (0-1) S: Bob James (1) | Second | 1 out |
| » Major-league debuts: Ozzie Guillen (White Sox) |
| Thursday, April 11 |
| » Defeated White Sox (1-1), 8-1 | County Stadium (1-1) | 1-1 | |
| » W: Ray Burris (1-0) L: Tim Lollar (0-1) | Fourth | 1½ out |
| Friday, April 12 |
| » Defeated Rangers (0-3), 11-6 | Arlington Stadium (1-0) | 2-1 | Won 2 |
| » W: Bob Gibson (1-0) L: Frank Tanana (0-1) | Second | 1 out |
| Saturday, April 13 |
| » Defeated Rangers (0-4), 6-5 | Arlington Stadium (2-0) | 3-1 | Won 3 |
| » W: Bob Gibson (2-0) L: Dickie Noles (0-1) S: Rollie Fingers (1) | Second | 1 out |
| Sunday, April 14 |
| » Defeated Rangers (0-5), 8-1 | Arlington Stadium (3-0) | 4-1 | Won 4 |
| » W: Moose Haas (1-1) L: Dave Rozema (0-2) | Second | 1 out |
| Tuesday, April 16 |
| » Lost to Tigers (6-0), 2-1 | Tiger Stadium (0-1) | 4-2 | |
| » W: Walt Terrell (1-0) L: Ray Burris (1-1) S: Aurelio Lopez (2) | Second | 2 out |
| Wednesday, April 17 |
| » Defeated Tigers (6-1), 2-0 | Tiger Stadium (1-1) | 5-2 | |
| » W: Danny Darwin (1-0) L: Jack Morris (2-1) | Second | 1 out |
| Friday, April 19 |
| » Lost to Rangers (2-7), 4-1 | County Stadium (1-2) | 5-3 | |
| » W: Dave Rozema (1-2) L: Ray Searage (0-1) S: Dave Stewart (1) | Second | 1 out |
| Saturday, April 20 |
| » Lost to Rangers (3-7), 5-1 | County Stadium (1-3) | 5-4 | Lost 2 |
| » W: Dickie Noles (1-1) L: Moose Haas (1-2) | Third | 2 out |
| Sunday, April 21 |
| » Lost to Rangers (4-7), 5-2 | County Stadium (1-4) | 5-5 | Lost 3 |
| » W: Mike Mason (2-1) L: Ray Burris (1-2) S: Dave Stewart (2) | Fourth | 2 out |
| Monday, April 22 |
| » Defeated White Sox (5-6), 4-2 | Comiskey Park I (1-0) | 6-5 | |
| » W: Danny Darwin (2-0) L: Juan Agosto (0-1) S: Rollie Fingers (2) | Second | 1 out |
| Tuesday, April 23 |
| » Lost to White Sox (6-6), 6-5 | Comiskey Park I (1-1) | 6-6 | |
| » W: Bob James (1-0) L: Rollie Fingers (0-1) | Third | 2 out |
| » Major-league debuts: Ted Higuera (Brewers) |
| Wednesday, April 24 |
| » Defeated White Sox (6-7), 3-2 | Comiskey Park I (2-1) | 7-6 | |
| » W: Pete Vuckovich (1-0) L: Britt Burns (2-1) S: Ray Searage (1) | Third | 1 out |
| Thursday, April 25 |
| » Defeated Tigers (8-6), 11-7 | County Stadium (2-4) | 8-6 | Won 2 |
| » W: Bob Gibson (3-0) L: Bill Scherrer (0-1) | Second | ½ out |
| Friday, April 26 |
| » Lost to Tigers (9-6), 1-0 | County Stadium (2-5) | 8-7 | |
| » W: Jack Morris (3-2) L: Ray Burris (1-3) | Fourth | 1½ out |
| Saturday, April 27 |
| » Lost to Tigers (10-6), 3-2 | County Stadium (2-6) | 8-8 | Lost 2 |
| » W: Dan Petry (4-1) L: Danny Darwin (2-1) S: Willie Hernandez (4) | Fourth | 2 out |
| Sunday, April 28 |
| » Lost to Tigers (11-6), 5-0 | County Stadium (2-7) | 8-9 | Lost 3 |
| » W: Walt Terrell (2-0) L: Teddy Higuera (0-1) | Fourth | 3 out |
| Monday, April 29 |
| » Lost to Mariners (8-12), 9-7 | Kingdome (0-1) | 8-10 | Lost 4 |
| » W: Edwin Nunez (1-0) L: Ray Searage (0-2) | Fifth | 3½ out |
| Tuesday, April 30 |
| » Lost to Mariners (9-12), 4-2 | Kingdome (0-2) | 8-11 | Lost 5 |
| » W: Mark Langston (3-2) L: Bob Gibson (3-1) S: Edwin Nunez (4) | Fifth | 4½ out |
| Wednesday, May 1 |
| » Defeated Athletics (9-13), 7-4 | Oakland-Alameda County Stadium (1-0) | 9-11 | |
| » W: Danny Darwin (3-1) L: Steve McCatty (1-1) | Fourth | 4½ out |
| Thursday, May 2 |
| » Lost to Athletics (10-13), 5-4 | Oakland-Alameda County Stadium (1-1) | 9-12 | |
| » W: Keith Atherton (2-2) L: Ray Searage (0-3) | Fifth | 4½ out |
| Friday, May 3 |
| » Defeated Angels (15-9), 7-0 | Anaheim Stadium (1-0) | 10-12 | |
| » W: Teddy Higuera (1-1) L: Tommy John (1-2) | Fifth | 4½ out |
| Saturday, May 4 |
| » Lost to Angels (16-9), 4-3 | Anaheim Stadium (1-1) | 10-13 | |
| » W: Ron Romanick (3-1) L: Pete Vuckovich (1-1) S: Donnie Moore (5) | Fifth | 4½ out |
| Sunday, May 5 |
| » Lost to Angels (17-9), 5-1 | Anaheim Stadium (1-2) | 10-14 | Lost 2 |
| » W: Mike Witt (2-3) L: Danny Darwin (3-2) S: Donnie Moore (6) | Sixth | 5½ out |
| Tuesday, May 7 |
| » Defeated Mariners (12-15), 5-2 | County Stadium (3-7) | 11-14 | |
| » W: Moose Haas (2-2) L: Jim Beattie (1-3) | Fifth | 5½ out |
| Wednesday, May 8 |
| » Lost to Mariners (13-15), 4-2 | County Stadium (3-8) | 11-15 | |
| » W: Mike Moore (3-3) L: Ray Burris (1-4) S: Edwin Nunez (5) | Fifth | 5½ out |
| Friday, May 10 |
| » Lost to Angels (18-11), 5-4 | County Stadium (3-9) | 11-16 | Lost 2 |
| » W: Ron Romanick (4-1) L: Pete Vuckovich (1-2) S: Donnie Moore (7) | Sixth | 6½ out |
| Saturday, May 11 |
| » Lost to Angels (19-11), 6-5 | County Stadium (3-10) | 11-17 | Lost 3 |
| » W: Tommy John (2-2) L: Jim Kern (0-1) S: Donnie Moore (8) | Sixth | 7½ out |
| Sunday, May 12 |
| » Defeated Angels (19-12), 7-4 | County Stadium (4-10) | 12-17 | |
| » W: Moose Haas (3-2) L: Kirk McCaskill (0-3) S: Rollie Fingers (3) | Sixth | 6½ out |
| Tuesday, May 14 |
| » Lost to Athletics (15-17), 6-3 | County Stadium (4-11) | 12-18 | |
| » W: Chris Codiroli (4-1) L: Rollie Fingers (0-2) | Sixth | 7½ out |
| » Major-league debuts: Ernest Riles (Brewers) |
| Wednesday, May 15 |
| » Lost to Athletics (16-17), 19-3 | County Stadium (4-12) | 12-19 | Lost 2 |
| » W: Bill Krueger (4-3) L: Teddy Higuera (1-2) | Sixth | 7½ out |
| Friday, May 17 |
| » Lost to Royals (18-15), 3-0 | County Stadium (4-13) | 12-20 | Lost 3 |
| » W: Bret Saberhagen (3-3) L: Danny Darwin (3-3) | Fifth | 7½ out |
| Saturday, May 18 |
| » Defeated Royals (18-16), 7-2 | County Stadium (5-13) | 13-20 | |
| » W: Moose Haas (4-2) L: Danny Jackson (2-2) | Sixth | 7½ out |
| Sunday, May 19 |
| » Defeated Royals (18-17), 11-10 | County Stadium (6-13) | 14-20 | Won 2 |
| » W: Bob Gibson (4-1) L: Dan Quisenberry (3-3) | Fifth | 6½ out |
| Tuesday, May 21 |
| » Lost to Indians (15-22), 6-4 | Cleveland Stadium (0-1) | 14-21 | |
| » W: Bryan Clark (1-0) L: Teddy Higuera (1-3) S: Rich Thompson (1) | Seventh | 8 out |
| Wednesday, May 22 |
| » Defeated Indians (15-23), 6-5 | Cleveland Stadium (1-1) | 15-21 | |
| » W: Bob Gibson (5-1) L: Bert Blyleven (2-5) S: Rollie Fingers (4) | Sixth | 8 out |
| Friday, May 24 |
| » Defeated Twins (21-19), 5-2 | County Stadium (7-13) | 16-21 | Won 2 |
| » W: Ray Burris (2-4) L: Mike Smithson (4-4) S: Rollie Fingers (5) | Sixth | 8½ out |
| Saturday, May 25 |
| » Defeated Twins (21-20), 9-7 | County Stadium (8-13) | 17-21 | Won 3 |
| » W: Bob McClure (1-0) L: Pete Filson (2-1) S: Rollie Fingers (6) | Fifth | 8½ out |
| Sunday, May 26 |
| » Defeated Twins (21-21), 5-3 | County Stadium (9-13) | 18-21 | Won 4 |
| » W: Teddy Higuera (2-3) L: John Butcher (4-3) S: Bob Gibson (1) | Fifth | 8½ out |
| Monday, May 27 |
| » Lost to Indians (16-27), 8-0 | County Stadium (9-14) | 18-22 | |
| » W: Bert Blyleven (3-5) L: Danny Darwin (3-4) | Fifth | 9 out |
| Tuesday, May 28 |
| » Defeated Indians (16-28), 3-2 | County Stadium (10-14) | 19-22 | |
| » W: Moose Haas (5-2) L: Neal Heaton (3-4) S: Rollie Fingers (7) | Fifth | 9 out |
| Wednesday, May 29 |
| » Defeated Indians (16-29), 7-2 | County Stadium (11-14) | 20-22 | Won 2 |
| » W: Ray Burris (3-4) L: Don Schulze (3-4) S: Bob Gibson (2) | Fifth | 8 out |
| Friday, May 31 |
| » Defeated Twins (21-25), 6-4 | Hubert H. Humphrey Metrodome (1-0) | 21-22 | Won 3 |
| » W: Teddy Higuera (3-3) L: Pete Filson (2-2) S: Rollie Fingers (8) | Fifth | 8 out |
| Saturday, June 1 |
| » Defeated Twins (21-26), 7-2 | Hubert H. Humphrey Metrodome (2-0) | 22-22 | Won 4 |
| » W: Danny Darwin (4-4) L: John Butcher (4-4) | Fourth | 8 out |
| Sunday, June 2 |
| » Lost to Twins (22-26), 5-4 | Hubert H. Humphrey Metrodome (2-1) | 22-23 | |
| » W: Ken Schrom (4-4) L: Bob Gibson (5-2) | Fifth | 8½ out |
| Tuesday, June 4 |
| » Lost to Royals (26-23), 4-3 | Royals Stadium (0-1) | 22-24 | Lost 2 |
| » W: Charlie Leibrandt (6-3) L: Pete Vuckovich (1-3) S: Mike LaCoss (1) | Fifth | 9½ out |
| Wednesday, June 5 |
| » Defeated Royals (26-24), 10-2 | Royals Stadium (1-1) | 23-24 | |
| » W: Teddy Higuera (4-3) L: Bud Black (5-5) | Sixth | 9½ out |
| Thursday, June 6 |
| » Defeated Yankees (26-23), 5-1 | County Stadium (12-14) | 24-24 | Won 2 |
| » W: Danny Darwin (5-4) L: Ed Whitson (1-6) | Fifth | 9½ out |
| Friday, June 7 |
| » Defeated Yankees (26-24), 10-9 | County Stadium (13-14) | 25-24 | Won 3 |
| » W: Ray Searage (1-3) L: Dave Righetti (3-5) | Sixth | 9½ out |
| Saturday, June 8 |
| » Lost to Yankees (27-24), 2-1 | County Stadium (13-15) | 25-25 | |
| » W: Dave Righetti (4-5) L: Bob Gibson (5-3) S: Rich Bordi (1) | Sixth | 9½ out |
| Sunday, June 9 |
| » Defeated Yankees (27-25), 9-4 | County Stadium (14-15) | 26-25 | |
| » W: Pete Vuckovich (2-3) L: Phil Niekro (7-4) S: Pete Ladd (1) | Fifth | 8½ out |
| Monday, June 10 |
| » Lost to Red Sox (29-25), 4-2 | Fenway Park (0-1) | 26-26 | |
| » W: Bob Ojeda (4-1) L: Teddy Higuera (4-4) | Fifth | 8½ out |
| Tuesday, June 11 |
| » Defeated Red Sox (29-26), 5-3 | Fenway Park (1-1) | 27-26 | |
| » W: Danny Darwin (6-4) L: Bruce Hurst (2-5) S: Bob Gibson (3) | Sixth | 8½ out |
| Wednesday, June 12 |
| » Lost to Red Sox (30-26), 7-2 | Fenway Park (1-2) | 27-27 | |
| » W: Al Nipper (3-5) L: Moose Haas (5-3) | Sixth | 9½ out |
| Thursday, June 13 |
| » Lost to Orioles (30-26), 8-3 | Memorial Stadium (0-1) | 27-28 | Lost 2 |
| » W: Scott McGregor (5-5) L: Ray Burris (3-5) | Sixth | 9½ out |
| Friday, June 14 |
| » Lost to Orioles (31-26), 9-3 | Memorial Stadium (0-2) | 27-29 | Lost 3 |
| » W: Storm Davis (4-2) L: Pete Vuckovich (2-4) | Sixth | 9½ out |
| Saturday, June 15 |
| » Lost to Orioles (32-26), 7-5 | Memorial Stadium (0-3) | 27-30 | Lost 4 |
| » W: Nate Snell (1-1) L: Bob Gibson (5-4) S: Tippy Martinez (3) | Sixth | 9½ out |
| Sunday, June 16 |
| » Lost to Orioles (33-26), 9-1 | Memorial Stadium (0-4) | 27-31 | Lost 5 |
| » W: Mike Boddicker (7-6) L: Danny Darwin (6-5) | Sixth | 9½ out |
| Monday, June 17 |
| » Defeated Blue Jays (38-24), 2-1 | County Stadium (15-15) | 28-31 | |
| » W: Moose Haas (6-3) L: Dave Stieb (6-5) | Sixth | 8½ out |
| Tuesday, June 18 |
| » Defeated Blue Jays (38-25), 4-1 | County Stadium (16-15) | 29-31 | Won 2 |
| » W: Ray Burris (4-5) L: Luis Leal (3-5) | Sixth | 7½ out |
| Wednesday, June 19 |
| » Lost to Blue Jays (39-25), 5-1 | County Stadium (16-16) | 29-32 | |
| » W: Jim Clancy (3-4) L: Pete Vuckovich (2-5) S: Bill Caudill (10) | Sixth | 8½ out |
| Friday, June 21 |
| » Defeated Orioles (33-30), 13-10 | County Stadium (17-16) | 30-32 | |
| » W: Jaime Cocanower (1-0) L: Sammy Stewart (2-3) S: Bob Gibson (4) | Sixth | 9 out |
| Saturday, June 22 |
| » Lost to Orioles (34-30), 3-2 | County Stadium (17-17) | 30-33 | |
| » W: Scott McGregor (6-6) L: Danny Darwin (6-6) S: Don Aase (2) | Sixth | 9 out |
| Sunday, June 23 |
| » Lost to Orioles (35-30), 6-3 | County Stadium (17-18) | 30-34 | Lost 2 |
| » W: Nate Snell (2-1) L: Rollie Fingers (0-3) | Sixth | 10 out |
| Tuesday, June 25 |
| » Lost to Blue Jays (43-26), 7-1 | Exhibition Stadium (0-1) | 30-35 | Lost 3 |
| » W: Jim Clancy (4-4) L: Ray Burris (4-6) | Fifth | 11 out |
| Wednesday, June 26 |
| » Defeated Blue Jays (43-27), 5-4 | Exhibition Stadium (1-1) | 31-35 | |
| » W: Bob Gibson (6-4) L: Doyle Alexander (7-4) | Sixth | 10 out |
| Thursday, June 27 |
| » Lost to Blue Jays (44-27), 7-3 | Exhibition Stadium (1-2) | 31-36 | |
| » W: Jimmy Key (6-2) L: Teddy Higuera (4-5) S: Jim Acker (9) | Sixth | 11 out |
| Friday, June 28 |
| » Lost to Yankees (37-32), 5-2 | Yankee Stadium (0-1) | 31-37 | Lost 2 |
| » W: Ron Guidry (9-3) L: Danny Darwin (6-7) S: Dave Righetti (13) | Sixth | 12 out |
| Saturday, June 29 |
| » Defeated Yankees (37-33), 6-0 | Yankee Stadium (1-1) | 32-37 | |
| » W: Moose Haas (7-3) L: Phil Niekro (7-7) | Sixth | 11 out |
| Sunday, June 30 |
| » Defeated Yankees (37-34), 7-5 | Yankee Stadium (2-1) | 33-37 | Won 2 |
| » W: Bob McClure (2-0) L: Brian Fisher (2-2) S: Rollie Fingers (9) | Fifth | 11 out |
| Monday, July 1 |
| » Defeated Red Sox (38-36), 5-1 | County Stadium (18-18) | 34-37 | Won 3 |
| » W: Pete Vuckovich (3-5) L: Mike Trujillo (1-2) S: Bob Gibson (5) | Sixth | 10 out |
| Tuesday, July 2 |
| » Defeated Red Sox (38-37), 4-3 | County Stadium (19-18) | 35-37 | Won 4 |
| » W: Rollie Fingers (1-3) L: Bob Stanley (3-4) | Sixth | 9 out |
| Wednesday, July 3 |
| » Lost to Red Sox (39-37), 9-0 | County Stadium (19-19) | 35-38 | |
| » W: Bruce Hurst (4-7) L: Danny Darwin (6-8) | Sixth | 10 out |
| Thursday, July 4 |
| » Lost to Mariners (39-38), 7-1 | Kingdome (0-3) | 35-39 | Lost 2 |
| » W: Mike Moore (7-4) L: Moose Haas (7-4) | Sixth | 10 out |
| Friday, July 5 |
| » Lost to Mariners (40-38), 7-6 | Kingdome (0-4) | 35-40 | Lost 3 |
| » W: Edwin Nunez (4-0) L: Rick Waits (0-1) | Sixth | 11 out |
| Saturday, July 6 |
| » Lost to Mariners (41-38), 5-3 | Kingdome (0-5) | 35-41 | Lost 4 |
| » W: Roy Thomas (4-0) L: Pete Vuckovich (3-6) S: Brian Snyder (1) | Sixth | 11 out |
| Sunday, July 7 |
| » Defeated Mariners (41-39), 2-1 | Kingdome (1-5) | 36-41 | |
| » W: Teddy Higuera (5-5) L: Bill Swift (3-2) S: Rollie Fingers (10) | Sixth | 11 out |
| Monday, July 8 |
| » Lost to Angels (47-34), 3-2 | Anaheim Stadium (1-3) | 36-42 | |
| » W: Donnie Moore (6-3) L: Bob Gibson (6-5) | Sixth | 12 out |
| Tuesday, July 9 |
| » Lost to Angels (48-34), 5-4 | Anaheim Stadium (1-4) | 36-43 | Lost 2 |
| » W: Donnie Moore (7-3) L: Rollie Fingers (1-4) | Sixth | 13 out |
| Wednesday, July 10 |
| » Lost to Angels (49-34), 2-1 | Anaheim Stadium (1-5) | 36-44 | Lost 3 |
| » W: Ron Romanick (10-4) L: Ray Burris (4-7) | Sixth | 14 out |
| Thursday, July 11 |
| » Lost to Athletics (44-40), 9-3 | Oakland-Alameda County Stadium (1-2) | 36-45 | Lost 4 |
| » W: Don Sutton (9-5) L: Pete Vuckovich (3-7) | Sixth | 15 out |
| Friday, July 12 |
| » Defeated Athletics (44-41), 5-3 | Oakland-Alameda County Stadium (2-2) | 37-45 | |
| » W: Teddy Higuera (6-5) L: Chris Codiroli (8-6) | Fifth | 14 out |
| Saturday, July 13 |
| » Lost to Athletics (45-41), 2-0 | Oakland-Alameda County Stadium (2-3) | 37-46 | |
| » W: Tim Birtsas (5-2) L: Danny Darwin (6-9) S: Steve Ontiveros (1) | Sixth | 14 out |
| Sunday, July 14 |
| » Lost to Athletics (46-41), 11-2 | Oakland-Alameda County Stadium (2-4) | 37-47 | Lost 2 |
| » W: Bill Krueger (7-8) L: Moose Haas (7-5) S: Keith Atherton (2) | Sixth | 14 out |
| Thursday, July 18 |
| » Lost to Mariners (43-45), 5-2 | County Stadium (19-20) | 37-48 | Lost 3 |
| » W: Mike Moore (8-5) L: Danny Darwin (6-10) | Sixth | 14 out |
| Friday, July 19 |
| » Defeated Mariners (43-46), 9-7 | County Stadium (20-20) | 38-48 | |
| » W: Teddy Higuera (7-5) L: Matt Young (7-10) S: Bob Gibson (6) | Sixth | 14 out |
| Saturday, July 20 |
| » Lost to Mariners (44-46), 13-10 | County Stadium (20-21) | 38-49 | |
| » W: Ed Vande Berg (1-1) L: Bob McClure (2-1) S: Roy Thomas (1) | Sixth | 14 out |
| Sunday, July 21 |
| » Defeated Mariners (44-47), 5-4 | County Stadium (21-21) | 39-49 | |
| » W: Ray Burris (5-7) L: Frank Wills (4-4) S: Bob Gibson (7) | Sixth | 14 out |
| Monday, July 22 |
| » Defeated Angels (54-38), 16-3 | County Stadium (22-21) | 40-49 | Won 2 |
| » W: Pete Vuckovich (4-7) L: Jim Slaton (4-9) S: Rick Waits (1) | Sixth | 14 out |
| Tuesday, July 23 |
| » Lost to Angels (55-38), 2-0 | County Stadium (22-22) | 40-50 | |
| » W: Kirk McCaskill (6-6) L: Danny Darwin (6-11) | Sixth | 15 out |
| Wednesday, July 24 |
| » Lost to Angels (56-38), 8-4 | County Stadium (22-23) | 40-51 | Lost 2 |
| » W: Ron Romanick (12-4) L: Teddy Higuera (7-6) | Sixth | 16 out |
| Thursday, July 25 |
| » Lost to Athletics (49-46), 11-2 | County Stadium (22-24) | 40-52 | Lost 3 |
| » W: Tim Birtsas (7-2) L: Jaime Cocanower (1-1) | Sixth | 17 out |
| Friday, July 26 |
| » Lost to Athletics (50-46), 7-3 | County Stadium (22-25) | 40-53 | Lost 4 |
| » W: Tommy John (3-4) L: Ray Burris (5-8) S: Keith Atherton (3) | Sixth | 18 out |
| Saturday, July 27 |
| » Defeated Athletics (50-47), 4-3 | County Stadium (23-25) | 41-53 | |
| » W: Pete Vuckovich (5-7) L: Chris Codiroli (8-8) S: Rollie Fingers (11) | Sixth | 18 out |
| Sunday, July 28 |
| » Lost to Athletics (51-47), 5-2 | County Stadium (23-26) | 41-54 | |
| » W: Bill Krueger (8-9) L: Danny Darwin (6-12) S: Jay Howell (20) | Sixth | 19 out |
| Monday, July 29 |
| » Defeated Rangers (39-60), 3-2 | County Stadium (24-26) | 42-54 | |
| » W: Teddy Higuera (8-6) L: Charlie Hough (9-11) | Sixth | 19 out |
| Tuesday, July 30 |
| » Defeated Rangers (39-61), 6-3 | County Stadium (25-26) | 43-54 | Won 2 |
| » W: Bob McClure (3-1) L: Dave Rozema (3-7) | Sixth | 18 out |
| Wednesday, July 31 |
| » Defeated Rangers (39-62), 5-2 | County Stadium (26-26) | 44-54 | Won 3 |
| » W: Jaime Cocanower (2-1) L: Mike Mason (5-10) | Sixth | 18 out |
| Friday, August 2 |
| » Lost to Tigers (54-46), 4-1 | Tiger Stadium (1-2) | 44-55 | |
| » W: Frank Tanana (6-10) L: Pete Vuckovich (5-8) | Sixth | 19½ out |
| Saturday, August 3 |
| » Lost to Tigers (55-46), 9-3 | Tiger Stadium (1-3) | 44-56 | Lost 2 |
| » W: Dan Petry (12-10) L: Danny Darwin (6-13) | Sixth | 20½ out |
| Sunday, August 4 |
| » Lost to Tigers (56-46), 7-4 | Tiger Stadium (1-4) | 44-57 | Lost 3 |
| » W: Willie Hernandez (6-4) L: Rick Waits (0-2) | Fifth | 20 out |
| » Defeated Tigers (56-47), 14-4 | Tiger Stadium (2-4) | 45-57 | |
| » W: Ray Burris (6-8) L: Randy O'Neal (5-4) | Fifth | 20 out |
| Thursday, August 8 |
| » Defeated Rangers (40-65), 7-4 | Arlington Stadium (4-0) | 46-57 | Won 2 |
| » W: Rick Waits (1-2) L: Jeff Russell (0-1) S: Bob Gibson (8) | Sixth | 20 out |
| » Defeated Rangers (40-66), 3-1 | Arlington Stadium (5-0) | 47-57 | Won 3 |
| » W: Pete Vuckovich (6-8) L: Burt Hooton (5-6) S: Rollie Fingers (12) | Sixth | 20 out |
| Friday, August 9 |
| » Defeated White Sox (53-52), 8-7 | Comiskey Park I (3-1) | 48-57 | Won 4 |
| » W: Rick Waits (2-2) L: Bob James (4-4) S: Rollie Fingers (13) | Sixth | 19 out |
| Saturday, August 10 |
| » Defeated White Sox (53-53), 5-2 | Comiskey Park I (4-1) | 49-57 | Won 5 |
| » W: Teddy Higuera (9-6) L: Juan Agosto (3-3) S: Bob Gibson (9) | Sixth | 18 out |
| Sunday, August 11 |
| » Lost to White Sox (54-53), 4-1 | Comiskey Park I (4-2) | 49-58 | |
| » W: Joel Davis (1-0) L: Ray Burris (6-9) S: Bob James (19) | Sixth | 19 out |
| » Major-league debuts: Joel Davis (White Sox) |
| Monday, August 12 |
| » Defeated Tigers (58-52), 4-3 | County Stadium (27-26) | 50-58 | |
| » W: Jaime Cocanower (3-1) L: Willie Hernandez (7-6) S: Rollie Fingers (14) | Sixth | 18 out |
| Tuesday, August 13 |
| » Lost to Tigers (59-52), 5-4 | County Stadium (27-27) | 50-59 | |
| » W: Aurelio Lopez (2-7) L: Bob Gibson (6-6) S: Willie Hernandez (23) | Sixth | 19 out |
| Wednesday, August 14 |
| » Lost to Tigers (60-52), 4-3 | County Stadium (27-28) | 50-60 | Lost 2 |
| » W: Jack Morris (13-6) L: Danny Darwin (6-14) S: Willie Hernandez (24) | Sixth | 20 out |
| Thursday, August 15 |
| » Defeated White Sox (55-56), 7-5 | County Stadium (28-28) | 51-60 | |
| » W: Teddy Higuera (10-6) L: Floyd Bannister (5-10) S: Rollie Fingers (15) | Sixth | 19½ out |
| Friday, August 16 |
| » Defeated White Sox (55-57), 3-2 | County Stadium (29-28) | 52-60 | Won 2 |
| » W: Ray Burris (7-9) L: Dave Wehrmeister (1-1) | Sixth | 18½ out |
| Saturday, August 17 |
| » Lost to White Sox (56-57), 12-7 | County Stadium (29-29) | 52-61 | |
| » W: Dan Spillner (3-3) L: Jaime Cocanower (3-2) | Sixth | 18½ out |
| Sunday, August 18 |
| » Lost to White Sox (57-57), 8-4 | County Stadium (29-30) | 52-62 | Lost 2 |
| » W: Britt Burns (13-7) L: Pete Vuckovich (6-9) S: Bob James (21) | Sixth | 19½ out |
| Monday, August 19 |
| » Defeated Twins (53-64), 4-1 | County Stadium (30-30) | 53-62 | |
| » W: Danny Darwin (7-14) L: Mike Smithson (11-11) | Sixth | 18½ out |
| Tuesday, August 20 |
| » Defeated Twins (53-65), 3-2 | County Stadium (31-30) | 54-62 | Won 2 |
| » W: Teddy Higuera (11-6) L: Steve Howe (2-3) | Sixth | 18½ out |
| Wednesday, August 21 |
| » Defeated Twins (53-66), 3-2 | County Stadium (32-30) | 55-62 | Won 3 |
| » W: Ray Burris (8-9) L: Steve Howe (2-4) | Sixth | 17½ out |
| Friday, August 23 |
| » Lost to Indians (41-79), 10-5 | Cleveland Stadium (1-2) | 55-63 | |
| » W: Curt Wardle (5-5) L: Jaime Cocanower (3-3) S: Vern Ruhle (1) | Sixth | 19 out |
| Sunday, August 25 |
| » Lost to Indians (42-79), 6-2 | Cleveland Stadium (1-3) | 55-64 | Lost 2 |
| » W: Tom Waddell (7-5) L: Moose Haas (7-6) | Sixth | 20 out |
| » Lost to Indians (43-79), 2-0 | Cleveland Stadium (1-4) | 55-65 | Lost 3 |
| » W: Ramon Romero (2-2) L: Danny Darwin (7-15) S: Bryan Clark (1) | Sixth | 20 out |
| Monday, August 26 |
| » Lost to Indians (44-79), 4-3 | Cleveland Stadium (1-5) | 55-66 | Lost 4 |
| » W: Neal Heaton (8-13) L: Bob Gibson (6-7) | Sixth | 20½ out |
| » Defeated Indians (44-80), 8-3 | Cleveland Stadium (2-5) | 56-66 | |
| » W: Ray Burris (9-9) L: Roy Smith (1-2) S: Rollie Fingers (16) | Sixth | 20½ out |
| Tuesday, August 27 |
| » Defeated Royals (68-55), 8-5 | County Stadium (33-30) | 57-66 | Won 2 |
| » W: Jaime Cocanower (4-3) L: Danny Jackson (12-8) S: Bob Gibson (10) | Sixth | 20½ out |
| Wednesday, August 28 |
| » Lost to Royals (69-55), 8-2 | County Stadium (33-31) | 57-67 | |
| » W: Mark Gubicza (10-7) L: Pete Vuckovich (6-10) | Sixth | 20½ out |
| Friday, August 30 |
| » Defeated Indians (46-82), 9-6 | County Stadium (34-31) | 58-67 | |
| » W: Moose Haas (8-6) L: Tom Waddell (7-6) | Sixth | 20½ out |
| Saturday, August 31 |
| » Defeated Indians (46-83), 10-8 | County Stadium (35-31) | 59-67 | Won 2 |
| » W: Teddy Higuera (12-6) L: Neal Heaton (8-14) S: Bob Gibson (11) | Sixth | 20½ out |
| Sunday, September 1 |
| » Lost to Indians (47-83), 11-4 | County Stadium (35-32) | 59-68 | |
| » W: Dave VonOhlen (3-1) L: Ray Burris (9-10) | Sixth | 20½ out |
| Monday, September 2 |
| » Lost to Twins (59-70), 6-1 | Hubert H. Humphrey Metrodome (2-2) | 59-69 | Lost 2 |
| » W: Mike Smithson (13-11) L: Jaime Cocanower (4-4) S: Ron Davis (19) | Sixth | 21½ out |
| Tuesday, September 3 |
| » Lost to Twins (60-70), 4-3 | Hubert H. Humphrey Metrodome (2-3) | 59-70 | Lost 3 |
| » W: Steve Howe (3-4) L: Danny Darwin (7-16) | Sixth | 22 out |
| Wednesday, September 4 |
| » Defeated Twins (60-71), 11-10 | Hubert H. Humphrey Metrodome (3-3) | 60-70 | |
| » W: Rick Waits (3-2) L: Dennis Burtt (0-1) S: Rollie Fingers (17) | Sixth | 21 out |
| Thursday, September 5 |
| » Lost to Royals (73-58), 4-1 | Royals Stadium (1-2) | 60-71 | |
| » W: Charlie Leibrandt (14-7) L: Moose Haas (8-7) | Sixth | 22 out |
| Friday, September 6 |
| » Lost to Royals (74-58), 4-3 | Royals Stadium (1-3) | 60-72 | Lost 2 |
| » W: Dan Quisenberry (7-8) L: Rollie Fingers (1-5) | Sixth | 23½ out |
| » Lost to Royals (75-58), 7-1 | Royals Stadium (1-4) | 60-73 | Lost 3 |
| » W: Steve Farr (1-0) L: Ray Burris (9-11) | Sixth | 23½ out |
| Saturday, September 7 |
| » Lost to Royals (76-58), 7-4 | Royals Stadium (1-5) | 60-74 | Lost 4 |
| » W: Mark Gubicza (12-7) L: Jaime Cocanower (4-5) S: Dan Quisenberry (32) | Sixth | 23½ out |
| Sunday, September 8 |
| » Lost to Royals (77-58), 13-11 | Royals Stadium (1-6) | 60-75 | Lost 5 |
| » W: Steve Farr (2-0) L: Rollie Fingers (1-6) | Sixth | 24½ out |
| Monday, September 9 |
| » Lost to Yankees (84-52), 9-4 | County Stadium (35-33) | 60-76 | Lost 6 |
| » W: Dave Righetti (12-7) L: Ray Searage (1-4) | Sixth | 25½ out |
| Tuesday, September 10 |
| » Lost to Yankees (85-52), 13-10 | County Stadium (35-34) | 60-77 | Lost 7 |
| » W: Ed Whitson (10-7) L: Ray Burris (9-12) S: Bob Shirley (2) | Sixth | 26½ out |
| Wednesday, September 11 |
| » Defeated Yankees (85-53), 4-3 | County Stadium (36-34) | 61-77 | |
| » W: Teddy Higuera (13-6) L: Rich Bordi (5-6) | Sixth | 26½ out |
| » Major-league debuts: Mike Felder and Billy Jo Robidoux (Brewers) |
| Friday, September 13 |
| » Defeated Red Sox (69-72), 6-3 | County Stadium (37-34) | 62-77 | Won 2 |
| » W: Tim Leary (1-0) L: Tim Lollar (7-10) S: Danny Darwin (1) | Sixth | 26 out |
| Saturday, September 14 |
| » Lost to Red Sox (70-72), 10-8 | County Stadium (37-35) | 62-78 | |
| » W: Bruce Kison (5-3) L: Danny Darwin (7-17) | Sixth | 27 out |
| » Major-league debuts: Bill Wegman (Brewers) |
| Sunday, September 15 |
| » Lost to Red Sox (71-72), 4-2 | County Stadium (37-36) | 62-79 | Lost 2 |
| » W: Jeff Sellers (1-0) L: Jaime Cocanower (4-6) S: Mike Trujillo (1) | Sixth | 28 out |
| » Major-league debuts: Jeff Sellers (Red Sox) |
| Monday, September 16 |
| » Defeated Red Sox (71-73), 5-3 | County Stadium (38-36) | 63-79 | |
| » W: Bob McClure (4-1) L: Bob Ojeda (7-10) | Sixth | 27½ out |
| Tuesday, September 17 |
| » Lost to Orioles (77-66), 6-0 | Memorial Stadium (0-5) | 63-80 | |
| » W: Ken Dixon (8-3) L: Teddy Higuera (13-7) | Sixth | 27½ out |
| Wednesday, September 18 |
| » Lost to Orioles (78-66), 4-2 | Memorial Stadium (0-6) | 63-81 | Lost 2 |
| » W: Scott McGregor (13-12) L: Tim Leary (1-1) | Sixth | 27½ out |
| Thursday, September 19 |
| » Defeated Orioles (78-67), 5-2 | Memorial Stadium (1-6) | 64-81 | |
| » W: Bill Wegman (1-0) L: Mike Boddicker (12-17) S: Bob McClure (1) | Sixth | 27 out |
| Friday, September 20 |
| » Lost to Blue Jays (92-54), 7-5 | Exhibition Stadium (1-3) | 64-82 | |
| » W: Jimmy Key (14-6) L: Jaime Cocanower (4-7) S: Gary Lavelle (7) | Sixth | 28 out |
| Saturday, September 21 |
| » Lost to Blue Jays (93-54), 2-1 | Exhibition Stadium (1-4) | 64-83 | Lost 2 |
| » W: Dennis Lamp (10-0) L: Danny Darwin (7-18) | Sixth | 29 out |
| Sunday, September 22 |
| » Defeated Blue Jays (93-55), 2-1 | Exhibition Stadium (2-4) | 65-83 | |
| » W: Teddy Higuera (14-7) L: Dave Stieb (13-12) | Sixth | 28 out |
| Monday, September 23 |
| » Lost to Blue Jays (94-55), 5-1 | Exhibition Stadium (2-5) | 65-84 | |
| » W: Jim Clancy (8-5) L: Tim Leary (1-2) S: Tom Henke (13) | Sixth | 29 out |
| Tuesday, September 24 |
| » Defeated Orioles (79-70), 10-6 | County Stadium (39-36) | 66-84 | |
| » W: Bill Wegman (2-0) L: Scott McGregor (13-13) S: Bob McClure (2) | Sixth | 29 out |
| » Major-league debuts: Eric Bell (Orioles) |
| Wednesday, September 25 |
| » Defeated Orioles (79-71), 3-0 | County Stadium (40-36) | 67-84 | Won 2 |
| » W: Jaime Cocanower (5-7) L: Mike Flanagan (4-5) | Sixth | 28 out |
| Thursday, September 26 |
| » Lost to Orioles (80-71), 9-1 | County Stadium (40-37) | 67-85 | |
| » W: Dennis Martinez (13-9) L: Moose Haas (8-8) | Sixth | 28 out |
| Friday, September 27 |
| » Lost to Blue Jays (96-57), 5-1 | County Stadium (40-38) | 67-86 | Lost 2 |
| » W: Dave Stieb (14-12) L: Teddy Higuera (14-8) S: Dennis Lamp (2) | Sixth | 29 out |
| Saturday, September 28 |
| » Lost to Blue Jays (97-57), 6-1 | County Stadium (40-39) | 67-87 | Lost 3 |
| » W: Jim Clancy (9-5) L: Tim Leary (1-3) S: Gary Lavelle (8) | Sixth | 30 out |
| Sunday, September 29 |
| » Lost to Blue Jays (98-57), 13-5 | County Stadium (40-40) | 67-88 | Lost 4 |
| » W: Jim Acker (7-2) L: Ray Burris (9-13) | Sixth | 31 out |
| Tuesday, October 1 |
| » Lost to Yankees (94-62), 6-1 | Yankee Stadium (2-2) | 67-89 | Lost 5 |
| » W: Joe Niekro (11-13) L: Jaime Cocanower (5-8) S: Dave Righetti (28) | Sixth | 31 out |
| Wednesday, October 2 |
| » Defeated Yankees (94-63), 1-0 | Yankee Stadium (3-2) | 68-89 | |
| » W: Teddy Higuera (15-8) L: Bob Shirley (5-5) | Sixth | 30 out |
| Thursday, October 3 |
| » Lost to Yankees (95-63), 3-0 | Yankee Stadium (3-3) | 68-90 | |
| » W: Ron Guidry (22-6) L: Tim Leary (1-4) S: Brian Fisher (14) | Sixth | 30 out |
| Friday, October 4 |
| » Defeated Red Sox (81-79), 8-7 | Fenway Park (2-2) | 69-90 | |
| » W: Brad Lesley (1-0) L: Mike Trujillo (4-4) S: Bob McClure (3) | Sixth | 29 out |
| Saturday, October 5 |
| » Defeated Red Sox (81-80), 3-2 | Fenway Park (3-2) | 70-90 | Won 2 |
| » W: Jaime Cocanower (6-8) L: Oil Can Boyd (15-13) S: Danny Darwin (2) | Fifth | 29 out |
| Sunday, October 6 |
| » Defeated Red Sox (81-81), 9-6 | Fenway Park (4-2) | 71-90 | Won 3 |
| » W: Danny Darwin (8-18) L: Bruce Hurst (11-13) S: Pete Ladd (2) | Sixth | 28 out |
Game information provided by Retrosheet (www.retrosheet.org) |