| Monday, April 8 |
| » Lost to Royals (1-0), 2-1 | Royals Stadium (0-1) | 0-1 | |
| » W: Bud Black (1-0) L: Dave Stieb (0-1) S: Dan Quisenberry (1) | Third | 1 out |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Wednesday, April 10 |
| » Defeated Royals (1-1), 1-0 | Royals Stadium (1-1) | 1-1 | |
| » W: Bill Caudill (1-0) L: Joe Beckwith (0-1) S: Gary Lavelle (1) | Second | 1 out |
| » Major-league debuts: Manny Lee (Blue Jays) |
| Thursday, April 11 |
| » Defeated Royals (1-2), 4-3 | Royals Stadium (2-1) | 2-1 | Won 2 |
| » W: Bill Caudill (2-0) L: Dan Quisenberry (0-1) S: Jim Acker (1) | Third | 1 out |
| Friday, April 12 |
| » Lost to Orioles (3-0), 7-2 | Memorial Stadium (0-1) | 2-2 | |
| » W: Scott McGregor (1-0) L: Jimmy Key (0-1) S: Sammy Stewart (2) | Third | 1½ out |
| Saturday, April 13 |
| » Lost to Orioles (4-0), 8-7 | Memorial Stadium (0-2) | 2-3 | Lost 2 |
| » W: Tippy Martinez (1-0) L: Bill Caudill (2-1) | Third | 2½ out |
| Sunday, April 14 |
| » Defeated Orioles (4-1), 5-3 | Memorial Stadium (1-2) | 3-3 | |
| » W: Doyle Alexander (1-0) L: Mike Boddicker (1-1) S: Jim Acker (2) | Third | 2½ out |
| Monday, April 15 |
| » Major-league debuts: Steve Lyons (Red Sox) |
| Tuesday, April 16 |
| » Lost to Rangers (1-5), 9-4 | Exhibition Stadium (0-1) | 3-4 | |
| » W: Mike Mason (1-1) L: Luis Leal (0-1) S: Dickie Noles (1) | Fifth | 3½ out |
| Wednesday, April 17 |
| » Defeated Rangers (1-6), 3-1 | Exhibition Stadium (1-1) | 4-4 | |
| » W: Bill Caudill (3-1) L: Dave Stewart (0-1) | Fourth | 2½ out |
| Thursday, April 18 |
| » Defeated Rangers (1-7), 4-2 | Exhibition Stadium (2-1) | 5-4 | Won 2 |
| » W: Dave Stieb (1-1) L: Frank Tanana (0-2) S: Bill Caudill (1) | Fifth | 2 out |
| Friday, April 19 |
| » Defeated Orioles (5-4), 6-5 | Exhibition Stadium (3-1) | 6-4 | Won 3 |
| » W: Doyle Alexander (2-0) L: Sammy Stewart (1-1) S: Bill Caudill (2) | Third | 1 out |
| Saturday, April 20 |
| » Defeated Orioles (5-5), 3-2 | Exhibition Stadium (4-1) | 7-4 | Won 4 |
| » W: Ron Musselman (1-0) L: Tippy Martinez (1-1) S: Gary Lavelle (2) | Second | 1 out |
| Sunday, April 21 |
| » Lost to Orioles (6-5), 3-2 | Exhibition Stadium (4-2) | 7-5 | |
| » W: Dennis Martinez (1-1) L: Jimmy Key (0-2) S: Tippy Martinez (1) | Second | 1 out |
| Monday, April 22 |
| » Lost to Royals (6-6), 2-0 | Exhibition Stadium (4-3) | 7-6 | Lost 2 |
| » W: Charlie Leibrandt (2-0) L: Dave Stieb (1-2) | Third | 1 out |
| Tuesday, April 23 |
| » Lost to Royals (7-6), 7-6 | Exhibition Stadium (4-4) | 7-7 | Lost 3 |
| » W: Joe Beckwith (1-1) L: Bill Caudill (3-2) S: Dan Quisenberry (2) | Fourth | 2 out |
| Wednesday, April 24 |
| » Defeated Royals (7-7), 10-2 | Exhibition Stadium (5-4) | 8-7 | |
| » W: Luis Leal (1-1) L: Bret Saberhagen (1-2) | Fourth | 1 out |
| Friday, April 26 |
| » Defeated Rangers (5-10), 6-5 | Arlington Stadium (1-0) | 9-7 | Won 2 |
| » W: Dennis Lamp (1-0) L: Dave Schmidt (0-1) S: Bill Caudill (3) | Third | 1 out |
| Saturday, April 27 |
| » Defeated Rangers (5-11), 9-8 | Arlington Stadium (2-0) | 10-7 | Won 3 |
| » W: Jim Acker (1-0) L: Dave Stewart (0-2) S: Bill Caudill (4) | Second | ½ out |
| Sunday, April 28 |
| » Defeated Rangers (5-12), 6-3 | Arlington Stadium (3-0) | 11-7 | Won 4 |
| » W: Doyle Alexander (3-0) L: Mike Mason (2-2) | Second | ½ out |
| Monday, April 29 |
| » Defeated Athletics (9-11), 2-1 | Oakland-Alameda County Stadium (1-0) | 12-7 | Won 5 |
| » W: Luis Leal (2-1) L: Bill Krueger (2-2) S: Bill Caudill (5) | Second | 1 out |
| Tuesday, April 30 |
| » Defeated Athletics (9-12), 4-3 | Oakland-Alameda County Stadium (2-0) | 13-7 | Won 6 |
| » W: Dennis Lamp (2-0) L: Jay Howell (0-1) S: Jim Acker (3) | First | -- |
| Wednesday, May 1 |
| » Defeated Angels (14-8), 6-3 | Anaheim Stadium (1-0) | 14-7 | Won 7 |
| » W: Jimmy Key (1-2) L: Kirk McCaskill (0-1) | First | -- |
| » Major-league debuts: Kirk McCaskill (Angels) |
| Thursday, May 2 |
| » Lost to Angels (15-8), 3-2 | Anaheim Stadium (1-1) | 14-8 | |
| » W: Pat Clements (2-0) L: Dave Stieb (1-3) | Second | 1 out |
| Friday, May 3 |
| » Defeated Mariners (10-14), 5-4 | Kingdome (1-0) | 15-8 | |
| » W: Doyle Alexander (4-0) L: Salome Barojas (0-3) S: Bill Caudill (6) | Second | 1 out |
| Saturday, May 4 |
| » Lost to Mariners (11-14), 8-1 | Kingdome (1-1) | 15-9 | |
| » W: Matt Young (2-3) L: Luis Leal (2-2) | Second | 1 out |
| Sunday, May 5 |
| » Lost to Mariners (12-14), 4-1 | Kingdome (1-2) | 15-10 | Lost 2 |
| » W: Mark Langston (4-2) L: Jim Clancy (0-1) | Second | 1 out |
| Tuesday, May 7 |
| » Defeated Athletics (11-16), 10-1 | Exhibition Stadium (6-4) | 16-10 | |
| » W: Dave Stieb (2-3) L: Don Sutton (2-3) | Second | 1 out |
| Wednesday, May 8 |
| » Lost to Athletics (12-16), 6-4 | Exhibition Stadium (6-5) | 16-11 | |
| » W: Steve McCatty (2-1) L: Doyle Alexander (4-1) S: Jay Howell (8) | Third | 1 out |
| Friday, May 10 |
| » Defeated Mariners (13-16), 8-3 | Exhibition Stadium (7-5) | 17-11 | |
| » W: Jimmy Key (2-2) L: Mark Langston (4-3) S: Jim Acker (4) | Third | 1 out |
| Saturday, May 11 |
| » Defeated Mariners (13-17), 4-2 | Exhibition Stadium (8-5) | 18-11 | Won 2 |
| » W: Bill Caudill (4-2) L: Matt Young (2-4) | Second | 1 out |
| Sunday, May 12 |
| » Defeated Mariners (13-18), 9-5 | Exhibition Stadium (9-5) | 19-11 | Won 3 |
| » W: Dave Stieb (3-3) L: Jim Beattie (1-4) | Second | 1 out |
| Tuesday, May 14 |
| » Defeated Angels (19-13), 6-3 | Exhibition Stadium (10-5) | 20-11 | Won 4 |
| » W: Doyle Alexander (5-1) L: Jim Slaton (3-2) S: Bill Caudill (7) | First | -- |
| Wednesday, May 15 |
| » Lost to Angels (20-13), 9-6 | Exhibition Stadium (10-6) | 20-12 | |
| » W: Donnie Moore (2-1) L: Bill Caudill (4-3) | First | -- |
| Friday, May 17 |
| » Lost to Twins (19-15), 7-6 | Hubert H. Humphrey Metrodome (0-1) | 20-13 | Lost 2 |
| » W: Pete Filson (1-0) L: Luis Leal (2-3) | First | -- |
| Saturday, May 18 |
| » Defeated Twins (19-16), 3-1 | Hubert H. Humphrey Metrodome (1-1) | 21-13 | |
| » W: Jim Clancy (1-1) L: Mike Smithson (4-3) S: Jim Acker (5) | First | -- |
| Sunday, May 19 |
| » Lost to Twins (20-16), 8-2 | Hubert H. Humphrey Metrodome (1-2) | 21-14 | |
| » W: Pete Filson (2-0) L: Doyle Alexander (5-2) | First | -- |
| Monday, May 20 |
| » Defeated White Sox (19-15), 6-1 | Exhibition Stadium (11-6) | 22-14 | |
| » W: Jimmy Key (3-2) L: Tom Seaver (4-2) | First | -- |
| Tuesday, May 21 |
| » Defeated White Sox (19-16), 4-3 | Exhibition Stadium (12-6) | 23-14 | Won 2 |
| » W: Gary Lavelle (1-0) L: Bob James (1-1) | First | -- |
| Wednesday, May 22 |
| » Defeated White Sox (19-17), 10-0 | Exhibition Stadium (13-6) | 24-14 | Won 3 |
| » W: Dave Stieb (4-3) L: Richard Dotson (2-2) | First | -- |
| Thursday, May 23 |
| » Defeated Indians (15-24), 6-5 | Cleveland Stadium (1-0) | 25-14 | Won 4 |
| » W: Dennis Lamp (3-0) L: Tom Waddell (1-3) S: Bill Caudill (8) | First | -- |
| Friday, May 24 |
| » Defeated Indians (15-25), 7-6 | Cleveland Stadium (2-0) | 26-14 | Won 5 |
| » W: Dennis Lamp (4-0) L: Keith Creel (0-2) S: Gary Lavelle (3) | First | -- |
| Saturday, May 25 |
| » Defeated Indians (15-26), 10-7 | Cleveland Stadium (3-0) | 27-14 | Won 6 |
| » W: Ron Musselman (2-0) L: Rich Thompson (1-2) S: Jim Acker (6) | First | -- |
| Sunday, May 26 |
| » Defeated Indians (15-27), 6-5 | Cleveland Stadium (4-0) | 28-14 | Won 7 |
| » W: Gary Lavelle (2-0) L: Keith Creel (0-3) S: Bill Caudill (9) | First | -- |
| Tuesday, May 28 |
| » Defeated White Sox (19-21), 6-1 | Comiskey Park I (1-0) | 29-14 | Won 8 |
| » W: Dave Stieb (5-3) L: Richard Dotson (2-3) | First | -- |
| Wednesday, May 29 |
| » Lost to White Sox (20-21), 8-5 | Comiskey Park I (1-1) | 29-15 | |
| » W: Britt Burns (6-4) L: Jim Clancy (1-2) S: Bob James (8) | First | -- |
| Friday, May 31 |
| » Defeated Indians (16-30), 7-2 | Exhibition Stadium (14-6) | 30-15 | |
| » W: Doyle Alexander (6-2) L: Bryan Clark (1-1) S: Jim Acker (7) | First | -- |
| Saturday, June 1 |
| » Defeated Indians (16-31), 8-3 | Exhibition Stadium (15-6) | 31-15 | Won 2 |
| » W: Jimmy Key (4-2) L: Bert Blyleven (3-6) | First | -- |
| Sunday, June 2 |
| » Lost to Indians (17-31), 5-4 | Exhibition Stadium (15-7) | 31-16 | |
| » W: Neal Heaton (4-4) L: Dave Stieb (5-4) S: Tom Waddell (8) | First | -- |
| » Defeated Indians (17-32), 5-2 | Exhibition Stadium (16-7) | 32-16 | |
| » W: Luis Leal (3-3) L: Rick Behenna (0-1) S: Jim Acker (8) | First | -- |
| Tuesday, June 4 |
| » Defeated Twins (22-27), 9-2 | Exhibition Stadium (17-7) | 33-16 | Won 2 |
| » W: Jim Clancy (2-2) L: Frank Viola (6-5) | First | -- |
| Wednesday, June 5 |
| » Defeated Twins (22-28), 5-0 | Exhibition Stadium (18-7) | 34-16 | Won 3 |
| » W: Doyle Alexander (7-2) L: Mike Smithson (4-5) | First | -- |
| Thursday, June 6 |
| » Defeated Tigers (27-23), 2-0 | Exhibition Stadium (19-7) | 35-16 | Won 4 |
| » W: Jim Acker (2-0) L: Aurelio Lopez (0-4) | First | -- |
| Friday, June 7 |
| » Defeated Tigers (27-24), 9-2 | Exhibition Stadium (20-7) | 36-16 | Won 5 |
| » W: Dave Stieb (6-4) L: Walt Terrell (6-2) | First | -- |
| Saturday, June 8 |
| » Lost to Tigers (28-24), 10-1 | Exhibition Stadium (20-8) | 36-17 | |
| » W: Randy O'Neal (1-0) L: Luis Leal (3-4) | First | -- |
| Sunday, June 9 |
| » Lost to Tigers (29-24), 8-3 | Exhibition Stadium (20-9) | 36-18 | Lost 2 |
| » W: Doug Bair (1-0) L: Jim Clancy (2-3) | First | -- |
| Monday, June 10 |
| » Lost to Yankees (28-25), 4-2 | Yankee Stadium (0-1) | 36-19 | Lost 3 |
| » W: Bob Shirley (1-1) L: Doyle Alexander (7-3) S: Dave Righetti (11) | First | -- |
| Tuesday, June 11 |
| » Defeated Yankees (28-26), 4-1 | Yankee Stadium (1-1) | 37-19 | |
| » W: Dennis Lamp (5-0) L: Brian Fisher (2-1) | First | -- |
| Wednesday, June 12 |
| » Defeated Yankees (28-27), 3-2 | Yankee Stadium (2-1) | 38-19 | Won 2 |
| » W: Jim Acker (3-0) L: Rich Bordi (1-1) | First | -- |
| Thursday, June 13 |
| » Lost to Red Sox (31-26), 8-7 | Fenway Park (0-1) | 38-20 | |
| » W: Mike Trujillo (1-1) L: Gary Lavelle (2-1) S: Bob Stanley (8) | First | -- |
| Friday, June 14 |
| » Lost to Red Sox (32-26), 4-1 | Fenway Park (0-2) | 38-21 | Lost 2 |
| » W: Oil Can Boyd (8-4) L: Jim Clancy (2-4) | First | -- |
| Saturday, June 15 |
| » Lost to Red Sox (33-26), 7-5 | Fenway Park (0-3) | 38-22 | Lost 3 |
| » W: Bob Stanley (2-2) L: Jim Acker (3-1) | First | -- |
| Sunday, June 16 |
| » Lost to Red Sox (34-26), 7-6 | Fenway Park (0-4) | 38-23 | Lost 4 |
| » W: Steve Crawford (4-2) L: Gary Lavelle (2-2) | First | -- |
| Monday, June 17 |
| » Lost to Brewers (28-31), 2-1 | County Stadium (0-1) | 38-24 | Lost 5 |
| » W: Moose Haas (6-3) L: Dave Stieb (6-5) | First | -- |
| Tuesday, June 18 |
| » Lost to Brewers (29-31), 4-1 | County Stadium (0-2) | 38-25 | Lost 6 |
| » W: Ray Burris (4-5) L: Luis Leal (3-5) | First | -- |
| Wednesday, June 19 |
| » Defeated Brewers (29-32), 5-1 | County Stadium (1-2) | 39-25 | |
| » W: Jim Clancy (3-4) L: Pete Vuckovich (2-5) S: Bill Caudill (10) | First | -- |
| Thursday, June 20 |
| » Defeated Red Sox (35-29), 6-5 | Exhibition Stadium (21-9) | 40-25 | Won 2 |
| » W: Jim Acker (4-1) L: Bob Stanley (2-3) S: Bill Caudill (11) | First | -- |
| Friday, June 21 |
| » Defeated Red Sox (35-30), 7-2 | Exhibition Stadium (22-9) | 41-25 | Won 3 |
| » W: Jimmy Key (5-2) L: Bruce Hurst (2-7) | First | -- |
| Saturday, June 22 |
| » Lost to Red Sox (36-30), 5-3 | Exhibition Stadium (22-10) | 41-26 | |
| » W: Bob Stanley (3-3) L: Jim Acker (4-2) | First | -- |
| Sunday, June 23 |
| » Defeated Red Sox (36-31), 8-1 | Exhibition Stadium (23-10) | 42-26 | |
| » W: Dave Stieb (7-5) L: Bruce Kison (3-2) | First | -- |
| Tuesday, June 25 |
| » Defeated Brewers (30-35), 7-1 | Exhibition Stadium (24-10) | 43-26 | Won 2 |
| » W: Jim Clancy (4-4) L: Ray Burris (4-6) | First | -- |
| Wednesday, June 26 |
| » Lost to Brewers (31-35), 5-4 | Exhibition Stadium (24-11) | 43-27 | |
| » W: Bob Gibson (6-4) L: Doyle Alexander (7-4) | First | -- |
| Thursday, June 27 |
| » Defeated Brewers (31-36), 7-3 | Exhibition Stadium (25-11) | 44-27 | |
| » W: Jimmy Key (6-2) L: Teddy Higuera (4-5) S: Jim Acker (9) | First | -- |
| Friday, June 28 |
| » Defeated Tigers (40-29), 2-0 | Tiger Stadium (1-0) | 45-27 | Won 2 |
| » W: Dave Stieb (8-5) L: Dan Petry (9-6) | First | -- |
| Saturday, June 29 |
| » Lost to Tigers (41-29), 8-0 | Tiger Stadium (1-1) | 45-28 | |
| » W: Walt Terrell (9-3) L: Luis Leal (3-6) | First | -- |
| Sunday, June 30 |
| » Defeated Tigers (41-30), 6-5 | Tiger Stadium (2-1) | 46-28 | |
| » W: Gary Lavelle (3-2) L: Aurelio Lopez (1-5) S: Dennis Lamp (1) | First | -- |
| Monday, July 1 |
| » Lost to Yankees (38-34), 4-1 | Exhibition Stadium (25-12) | 46-29 | |
| » W: Joe Cowley (7-3) L: Doyle Alexander (7-5) S: Dave Righetti (14) | First | -- |
| Tuesday, July 2 |
| » Lost to Yankees (39-34), 5-3 | Exhibition Stadium (25-13) | 46-30 | Lost 2 |
| » W: Ed Whitson (4-6) L: Jimmy Key (6-3) | First | -- |
| Wednesday, July 3 |
| » Defeated Yankees (39-35), 3-2 | Exhibition Stadium (26-13) | 47-30 | |
| » W: Jim Acker (5-2) L: Rich Bordi (1-2) | First | -- |
| Thursday, July 4 |
| » Lost to Athletics (41-36), 3-2 | Oakland-Alameda County Stadium (2-1) | 47-31 | |
| » W: Jay Howell (8-3) L: Bill Caudill (4-4) | First | -- |
| Friday, July 5 |
| » Defeated Athletics (41-37), 8-2 | Oakland-Alameda County Stadium (3-1) | 48-31 | |
| » W: Jim Clancy (5-4) L: Bill Krueger (5-8) | First | -- |
| Saturday, July 6 |
| » Lost to Athletics (42-37), 5-1 | Oakland-Alameda County Stadium (3-2) | 48-32 | |
| » W: Don Sutton (8-5) L: Doyle Alexander (7-6) | First | -- |
| Sunday, July 7 |
| » Defeated Athletics (42-38), 8-2 | Oakland-Alameda County Stadium (4-2) | 49-32 | |
| » W: Jimmy Key (7-3) L: Steve McCatty (4-4) | First | -- |
| Monday, July 8 |
| » Defeated Mariners (41-40), 4-0 | Kingdome (2-2) | 50-32 | Won 2 |
| » W: Dave Stieb (9-5) L: Mike Moore (7-5) | First | -- |
| Tuesday, July 9 |
| » Defeated Mariners (41-41), 9-4 | Kingdome (3-2) | 51-32 | Won 3 |
| » W: Ron Musselman (3-0) L: Ed Vande Berg (0-1) | First | -- |
| Wednesday, July 10 |
| » Defeated Mariners (41-42), 11-1 | Kingdome (4-2) | 52-32 | Won 4 |
| » W: Jim Clancy (6-4) L: Frank Wills (4-2) | First | -- |
| Thursday, July 11 |
| » Defeated Angels (49-35), 5-3 | Anaheim Stadium (2-1) | 53-32 | Won 5 |
| » W: Doyle Alexander (8-6) L: Jim Slaton (4-8) S: Gary Lavelle (4) | First | -- |
| Friday, July 12 |
| » Lost to Angels (50-35), 5-3 | Anaheim Stadium (2-2) | 53-33 | |
| » W: Kirk McCaskill (5-5) L: Jimmy Key (7-4) S: Donnie Moore (17) | First | -- |
| Saturday, July 13 |
| » Lost to Angels (51-35), 4-3 | Anaheim Stadium (2-3) | 53-34 | Lost 2 |
| » W: Mike Witt (7-6) L: Gary Lavelle (3-3) | First | -- |
| Sunday, July 14 |
| » Lost to Angels (52-35), 5-3 | Anaheim Stadium (2-4) | 53-35 | Lost 3 |
| » W: Stew Cliburn (4-2) L: Gary Lavelle (3-4) | First | -- |
| Thursday, July 18 |
| » Lost to Athletics (47-41), 6-4 | Exhibition Stadium (26-14) | 53-36 | Lost 4 |
| » W: Steve Ontiveros (1-1) L: Gary Lavelle (3-5) S: Jay Howell (19) | First | -- |
| Friday, July 19 |
| » Defeated Athletics (47-42), 5-1 | Exhibition Stadium (27-14) | 54-36 | |
| » W: Jimmy Key (8-4) L: Don Sutton (9-6) | First | -- |
| Saturday, July 20 |
| » Lost to Athletics (48-42), 5-1 | Exhibition Stadium (27-15) | 54-37 | |
| » W: Tim Birtsas (6-2) L: Dave Stieb (9-6) S: Steve Ontiveros (2) | First | -- |
| » Major-league debuts: Cecil Fielder (Blue Jays) |
| Sunday, July 21 |
| » Defeated Athletics (48-43), 11-4 | Exhibition Stadium (28-15) | 55-37 | |
| » W: Dennis Lamp (6-0) L: Bill Krueger (7-9) | First | -- |
| Monday, July 22 |
| » Defeated Mariners (44-48), 3-1 | Exhibition Stadium (29-15) | 56-37 | Won 2 |
| » W: Tom Filer (1-0) L: Mark Langston (5-7) S: Bill Caudill (12) | First | -- |
| Tuesday, July 23 |
| » Defeated Mariners (44-49), 4-2 | Exhibition Stadium (30-15) | 57-37 | Won 3 |
| » W: Doyle Alexander (9-6) L: Mike Moore (8-6) S: Bill Caudill (13) | First | -- |
| Wednesday, July 24 |
| » Defeated Mariners (44-50), 3-1 | Exhibition Stadium (31-15) | 58-37 | Won 4 |
| » W: Jimmy Key (9-4) L: Matt Young (7-11) S: Gary Lavelle (5) | First | -- |
| Thursday, July 25 |
| » Defeated Angels (56-39), 7-0 | Exhibition Stadium (32-15) | 59-37 | Won 5 |
| » W: Dave Stieb (10-6) L: Mike Witt (8-7) | First | -- |
| Friday, July 26 |
| » Defeated Angels (56-40), 8-3 | Exhibition Stadium (33-15) | 60-37 | Won 6 |
| » W: Jim Clancy (7-4) L: Urbano Lugo (3-3) | First | -- |
| Saturday, July 27 |
| » Defeated Angels (56-41), 8-3 | Exhibition Stadium (34-15) | 61-37 | Won 7 |
| » W: Tom Filer (2-0) L: Tony Mack (0-1) S: Jim Acker (10) | First | -- |
| Sunday, July 28 |
| » Defeated Angels (56-42), 5-1 | Exhibition Stadium (35-15) | 62-37 | Won 8 |
| » W: Doyle Alexander (10-6) L: Kirk McCaskill (6-7) | First | -- |
| Monday, July 29 |
| » Defeated Orioles (50-47), 4-3 | Memorial Stadium (2-2) | 63-37 | Won 9 |
| » W: Tom Henke (1-0) L: Mike Boddicker (10-11) | First | -- |
| Tuesday, July 30 |
| » Lost to Orioles (51-47), 4-3 | Memorial Stadium (2-3) | 63-38 | |
| » W: Don Aase (6-5) L: Gary Lavelle (3-6) | First | -- |
| Wednesday, July 31 |
| » Defeated Orioles (51-48), 5-3 | Memorial Stadium (3-3) | 64-38 | |
| » W: Tom Henke (2-0) L: Dennis Martinez (7-7) | First | -- |
| Thursday, August 1 |
| » Defeated Orioles (51-49), 9-3 | Memorial Stadium (4-3) | 65-38 | Won 2 |
| » W: Tom Filer (3-0) L: Storm Davis (5-7) | First | -- |
| Friday, August 2 |
| » Defeated Rangers (39-63), 5-3 | Exhibition Stadium (36-15) | 66-38 | Won 3 |
| » W: Doyle Alexander (11-6) L: Glen Cook (2-3) S: Tom Henke (1) | First | -- |
| Saturday, August 3 |
| » Defeated Rangers (39-64), 4-1 | Exhibition Stadium (37-15) | 67-38 | Won 4 |
| » W: Dennis Lamp (7-0) L: Chris Welsh (2-3) S: Bill Caudill (14) | First | -- |
| Sunday, August 4 |
| » Lost to Rangers (40-64), 8-4 | Exhibition Stadium (37-16) | 67-39 | |
| » W: Charlie Hough (10-11) L: Dave Stieb (10-7) S: Dave Schmidt (4) | First | -- |
| Thursday, August 8 |
| » Defeated Orioles (53-51), 7-2 | Exhibition Stadium (38-16) | 68-39 | |
| » W: Doyle Alexander (12-6) L: Scott McGregor (9-9) | First | -- |
| » Defeated Orioles (53-52), 7-4 | Exhibition Stadium (39-16) | 69-39 | Won 2 |
| » W: Tom Filer (4-0) L: Mike Boddicker (10-13) S: Tom Henke (2) | First | -- |
| Friday, August 9 |
| » Lost to Royals (58-48), 4-2 | Royals Stadium (2-2) | 69-40 | |
| » W: Bud Black (8-11) L: Dave Stieb (10-8) | First | -- |
| Saturday, August 10 |
| » Lost to Royals (59-48), 4-3 | Royals Stadium (2-3) | 69-41 | Lost 2 |
| » W: Dan Quisenberry (6-6) L: Bill Caudill (4-5) | First | -- |
| Sunday, August 11 |
| » Defeated Royals (59-49), 5-3 | Royals Stadium (3-3) | 70-41 | |
| » W: Tom Henke (3-0) L: Joe Beckwith (1-5) | First | -- |
| Monday, August 12 |
| » Lost to Rangers (42-68), 5-4 | Arlington Stadium (3-1) | 70-42 | |
| » W: Dwayne Henry (1-0) L: Bill Caudill (4-6) | First | -- |
| Tuesday, August 13 |
| » Defeated Rangers (42-69), 5-3 | Arlington Stadium (4-1) | 71-42 | |
| » W: Tom Filer (5-0) L: Jeff Russell (0-2) S: Tom Henke (3) | First | -- |
| Wednesday, August 14 |
| » Defeated Rangers (42-70), 4-1 | Arlington Stadium (5-1) | 72-42 | Won 2 |
| » W: Dave Stieb (11-8) L: Charlie Hough (11-12) | First | -- |
| Friday, August 16 |
| » Lost to Royals (62-50), 4-2 | Exhibition Stadium (39-17) | 72-43 | |
| » W: Charlie Leibrandt (11-6) L: Jimmy Key (9-5) | First | -- |
| Saturday, August 17 |
| » Lost to Royals (63-50), 4-2 | Exhibition Stadium (39-18) | 72-44 | Lost 2 |
| » W: Danny Jackson (11-7) L: Doyle Alexander (12-7) S: Dan Quisenberry (28) | First | -- |
| Sunday, August 18 |
| » Defeated Royals (63-51), 10-6 | Exhibition Stadium (40-18) | 73-44 | |
| » W: Tom Filer (6-0) L: Mark Gubicza (9-7) | First | -- |
| Monday, August 19 |
| » Lost to Indians (39-78), 5-3 | Cleveland Stadium (4-1) | 73-45 | |
| » W: Tom Waddell (6-5) L: Dave Stieb (11-9) | First | -- |
| Tuesday, August 20 |
| » Defeated Indians (39-79), 3-2 | Cleveland Stadium (5-1) | 74-45 | |
| » W: Jimmy Key (10-5) L: Roy Smith (1-1) S: Tom Henke (4) | First | -- |
| Wednesday, August 21 |
| » Lost to Indians (40-79), 5-2 | Cleveland Stadium (5-2) | 74-46 | |
| » W: Neal Heaton (7-13) L: Doyle Alexander (12-8) | First | -- |
| Friday, August 23 |
| » Defeated White Sox (58-60), 6-3 | Comiskey Park I (2-1) | 75-46 | |
| » W: Tom Filer (7-0) L: Britt Burns (13-8) S: Tom Henke (5) | First | -- |
| » Defeated White Sox (58-61), 10-3 | Comiskey Park I (3-1) | 76-46 | Won 2 |
| » W: Jim Acker (6-2) L: Gene Nelson (7-8) | First | -- |
| Saturday, August 24 |
| » Defeated White Sox (58-62), 6-3 | Comiskey Park I (4-1) | 77-46 | Won 3 |
| » W: Dave Stieb (12-9) L: Tom Seaver (12-9) S: Tom Henke (6) | First | -- |
| Sunday, August 25 |
| » Lost to White Sox (59-62), 5-3 | Comiskey Park I (4-2) | 77-47 | |
| » W: Floyd Bannister (6-11) L: Jimmy Key (10-6) S: Bob James (22) | First | -- |
| » Major-league debuts: Steve Davis (Blue Jays) |
| Monday, August 26 |
| » Defeated Twins (55-67), 4-3 | Hubert H. Humphrey Metrodome (2-2) | 78-47 | |
| » W: Doyle Alexander (13-8) L: Bert Blyleven (12-13) S: Tom Henke (7) | First | -- |
| Tuesday, August 27 |
| » Defeated Twins (55-68), 8-0 | Hubert H. Humphrey Metrodome (3-2) | 79-47 | Won 2 |
| » W: Steve Davis (1-0) L: Frank Viola (13-11) | First | -- |
| Wednesday, August 28 |
| » Lost to Twins (56-68), 6-5 | Hubert H. Humphrey Metrodome (3-3) | 79-48 | |
| » W: Pete Filson (4-5) L: Tom Henke (3-1) | First | -- |
| Friday, August 30 |
| » Defeated White Sox (63-63), 5-3 | Exhibition Stadium (41-18) | 80-48 | |
| » W: Jimmy Key (11-6) L: Floyd Bannister (6-12) S: Tom Henke (8) | First | -- |
| Saturday, August 31 |
| » Defeated White Sox (63-64), 6-2 | Exhibition Stadium (42-18) | 81-48 | Won 2 |
| » W: Gary Lavelle (4-6) L: Joel Davis (1-2) | First | -- |
| Sunday, September 1 |
| » Lost to White Sox (64-64), 4-1 | Exhibition Stadium (42-19) | 81-49 | |
| » W: Britt Burns (15-8) L: Steve Davis (1-1) | First | -- |
| » Major-league debuts: John Cerutti (Blue Jays) |
| Monday, September 2 |
| » Defeated Indians (47-84), 3-2 | Exhibition Stadium (43-19) | 82-49 | |
| » W: Dave Stieb (13-9) L: Curt Wardle (6-6) S: Tom Henke (9) | First | -- |
| Wednesday, September 4 |
| » Lost to Indians (48-84), 5-4 | Exhibition Stadium (43-20) | 82-50 | |
| » W: Bryan Clark (2-3) L: Tom Henke (3-2) S: Rich Thompson (5) | First | -- |
| Thursday, September 5 |
| » Defeated Twins (60-72), 7-0 | Exhibition Stadium (44-20) | 83-50 | |
| » W: Doyle Alexander (14-8) L: Bert Blyleven (13-14) | First | -- |
| Friday, September 6 |
| » Defeated Twins (60-73), 8-3 | Exhibition Stadium (45-20) | 84-50 | Won 2 |
| » W: Steve Davis (2-1) L: Frank Viola (13-13) | First | -- |
| Saturday, September 7 |
| » Lost to Twins (61-73), 6-3 | Exhibition Stadium (45-21) | 84-51 | |
| » W: Mike Smithson (14-11) L: Dave Stieb (13-10) | First | -- |
| Sunday, September 8 |
| » Defeated Twins (61-74), 10-9 | Exhibition Stadium (46-21) | 85-51 | |
| » W: Dennis Lamp (8-0) L: Mark Portugal (1-2) S: Gary Lavelle (6) | First | -- |
| Monday, September 9 |
| » Defeated Tigers (71-65), 5-3 | Exhibition Stadium (47-21) | 86-51 | Won 2 |
| » W: Jimmy Key (12-6) L: Mickey Mahler (1-5) S: Tom Henke (10) | First | -- |
| Tuesday, September 10 |
| » Defeated Tigers (71-66), 2-1 | Exhibition Stadium (48-21) | 87-51 | Won 3 |
| » W: Doyle Alexander (15-8) L: Jack Morris (14-10) | First | -- |
| Wednesday, September 11 |
| » Defeated Tigers (71-67), 3-2 | Exhibition Stadium (49-21) | 88-51 | Won 4 |
| » W: Dennis Lamp (9-0) L: Walt Terrell (13-9) S: Tom Henke (11) | First | -- |
| Thursday, September 12 |
| » Lost to Yankees (86-53), 7-5 | Yankee Stadium (2-2) | 88-52 | |
| » W: Ron Guidry (19-5) L: Gary Lavelle (4-7) S: Brian Fisher (12) | First | -- |
| Friday, September 13 |
| » Defeated Yankees (86-54), 3-2 | Yankee Stadium (3-2) | 89-52 | |
| » W: Gary Lavelle (5-7) L: Phil Niekro (15-10) S: Tom Henke (12) | First | -- |
| Saturday, September 14 |
| » Defeated Yankees (86-55), 7-4 | Yankee Stadium (4-2) | 90-52 | Won 2 |
| » W: Jimmy Key (13-6) L: Rich Bordi (5-7) | First | -- |
| Sunday, September 15 |
| » Defeated Yankees (86-56), 8-5 | Yankee Stadium (5-2) | 91-52 | Won 3 |
| » W: Doyle Alexander (16-8) L: Ed Whitson (10-8) | First | -- |
| Tuesday, September 17 |
| » Lost to Red Sox (72-73), 6-5 | Fenway Park (0-5) | 91-53 | |
| » W: Oil Can Boyd (14-11) L: Dave Stieb (13-11) S: Steve Crawford (10) | First | -- |
| Wednesday, September 18 |
| » Lost to Red Sox (73-73), 13-1 | Fenway Park (0-6) | 91-54 | Lost 2 |
| » W: Al Nipper (9-11) L: Jim Clancy (7-5) | First | -- |
| Friday, September 20 |
| » Defeated Brewers (64-82), 7-5 | Exhibition Stadium (50-21) | 92-54 | |
| » W: Jimmy Key (14-6) L: Jaime Cocanower (4-7) S: Gary Lavelle (7) | First | -- |
| Saturday, September 21 |
| » Defeated Brewers (64-83), 2-1 | Exhibition Stadium (51-21) | 93-54 | Won 2 |
| » W: Dennis Lamp (10-0) L: Danny Darwin (7-18) | First | -- |
| Sunday, September 22 |
| » Lost to Brewers (65-83), 2-1 | Exhibition Stadium (51-22) | 93-55 | |
| » W: Teddy Higuera (14-7) L: Dave Stieb (13-12) | First | -- |
| Monday, September 23 |
| » Defeated Brewers (65-84), 5-1 | Exhibition Stadium (52-22) | 94-55 | |
| » W: Jim Clancy (8-5) L: Tim Leary (1-2) S: Tom Henke (13) | First | -- |
| Tuesday, September 24 |
| » Defeated Red Sox (75-76), 6-2 | Exhibition Stadium (53-22) | 95-55 | Won 2 |
| » W: Dennis Lamp (11-0) L: Al Nipper (9-12) | First | -- |
| Wednesday, September 25 |
| » Lost to Red Sox (76-76), 4-2 | Exhibition Stadium (53-23) | 95-56 | |
| » W: Steve Crawford (6-4) L: John Cerutti (0-1) S: Tim Lollar (1) | First | -- |
| Thursday, September 26 |
| » Lost to Red Sox (77-76), 4-1 | Exhibition Stadium (53-24) | 95-57 | Lost 2 |
| » W: Jeff Sellers (2-0) L: Doyle Alexander (16-9) | First | -- |
| Friday, September 27 |
| » Defeated Brewers (67-86), 5-1 | County Stadium (2-2) | 96-57 | |
| » W: Dave Stieb (14-12) L: Teddy Higuera (14-8) S: Dennis Lamp (2) | First | -- |
| Saturday, September 28 |
| » Defeated Brewers (67-87), 6-1 | County Stadium (3-2) | 97-57 | Won 2 |
| » W: Jim Clancy (9-5) L: Tim Leary (1-3) S: Gary Lavelle (8) | First | -- |
| Sunday, September 29 |
| » Defeated Brewers (67-88), 13-5 | County Stadium (4-2) | 98-57 | Wo |