| Monday, April 8 |
| » Major-league debuts: Lou Thornton (Blue Jays) |
| Tuesday, April 9 |
| » Defeated Dodgers (0-1), 2-1 | Astrodome (1-0) | 1-0 | |
| » W: Nolan Ryan (1-0) L: Fernando Valenzuela (0-1) S: Frank DiPino (1) | First | -- |
| » Major-league debuts: Mariano Duncan (Dodgers) |
| Wednesday, April 10 |
| » Lost to Dodgers (1-1), 5-4 | Astrodome (1-1) | 1-1 | |
| » W: Jerry Reuss (1-0) L: Joe Niekro (0-1) S: Steve Howe (1) | Second | ½ out |
| Thursday, April 11 |
| » Lost to Dodgers (2-1), 4-3 | Astrodome (1-2) | 1-2 | Lost 2 |
| » W: Carlos Diaz (1-0) L: Bill Dawley (0-1) S: Ken Howell (1) | Fourth | 1½ out |
| Friday, April 12 |
| » Defeated Phillies (0-3), 8-3 | Astrodome (2-2) | 2-2 | |
| » W: Dave Smith (1-0) L: Larry Andersen (0-1) S: Jeff Calhoun (1) | Second | ½ out |
| Saturday, April 13 |
| » Lost to Phillies (1-3), 4-2 | Astrodome (2-3) | 2-3 | |
| » W: Shane Rawley (1-0) L: Ron Mathis (0-1) S: Al Holland (1) | Fourth | 1½ out |
| Sunday, April 14 |
| » Defeated Phillies (1-4), 5-3 | Astrodome (3-3) | 3-3 | |
| » W: Nolan Ryan (2-0) L: Steve Carlton (0-2) | Third | 1½ out |
| Monday, April 15 |
| » Lost to Dodgers (4-3), 5-3 | Dodger Stadium (0-1) | 3-4 | |
| » W: Carlos Diaz (2-0) L: Joe Niekro (0-2) S: Ken Howell (2) | Fourth | 1½ out |
| Tuesday, April 16 |
| » Defeated Dodgers (4-4), 7-3 | Dodger Stadium (1-1) | 4-4 | |
| » W: Dave Smith (2-0) L: Steve Howe (0-1) | Second | ½ out |
| Wednesday, April 17 |
| » Lost to Dodgers (5-4), 1-0 | Dodger Stadium (1-2) | 4-5 | |
| » W: Orel Hershiser (1-0) L: Frank DiPino (0-1) | Fourth | 1 out |
| Friday, April 19 |
| » Lost to Braves (5-4), 9-5 | Atlanta-Fulton County Stadium (0-1) | 4-6 | Lost 2 |
| » W: Rick Mahler (3-0) L: Nolan Ryan (2-1) | Fourth | 2 out |
| Saturday, April 20 |
| » Defeated Braves (5-5), 8-1 | Atlanta-Fulton County Stadium (1-1) | 5-6 | |
| » W: Joe Niekro (1-2) L: Pascual Perez (0-2) S: Frank DiPino (2) | Fifth | 2 out |
| Sunday, April 21 |
| » Defeated Braves (5-6), 4-2 | Atlanta-Fulton County Stadium (2-1) | 6-6 | Won 2 |
| » W: Bob Knepper (1-0) L: Len Barker (0-1) S: Dave Smith (1) | Fourth | 2 out |
| Monday, April 22 |
| » Defeated Reds (8-5), 4-1 | Astrodome (4-3) | 7-6 | Won 3 |
| » W: Mike Scott (1-0) L: Jay Tibbs (0-3) S: Dave Smith (2) | Fourth | 1 out |
| Tuesday, April 23 |
| » Defeated Reds (8-6), 6-4 | Astrodome (5-3) | 8-6 | Won 4 |
| » W: Ron Mathis (1-1) L: John Stuper (2-1) S: Dave Smith (3) | First | -- |
| Wednesday, April 24 |
| » Lost to Reds (9-6), 8-3 | Astrodome (5-4) | 8-7 | |
| » W: Mario Soto (4-1) L: Frank DiPino (0-2) | Fourth | 1 out |
| Thursday, April 25 |
| » Lost to Braves (7-8), 3-2 | Astrodome (5-5) | 8-8 | Lost 2 |
| » W: Zane Smith (2-1) L: Dave Smith (2-1) S: Bruce Sutter (4) | Fourth | 1½ out |
| Friday, April 26 |
| » Defeated Braves (7-9), 3-2 | Astrodome (6-5) | 9-8 | |
| » W: Frank DiPino (1-2) L: Rick Camp (0-3) | Second | 1½ out |
| Saturday, April 27 |
| » Lost to Braves (8-9), 8-2 | Astrodome (6-6) | 9-9 | |
| » W: Rick Mahler (5-0) L: Mike Scott (1-1) | Fourth | 1½ out |
| Sunday, April 28 |
| » Defeated Braves (8-10), 2-1 | Astrodome (7-6) | 10-9 | |
| » W: Dave Smith (3-1) L: Terry Forster (0-1) | Third | ½ out |
| Tuesday, April 30 |
| » Lost to Mets (12-6), 4-1 | Shea Stadium (0-1) | 10-10 | |
| » W: Dwight Gooden (3-1) L: Joe Niekro (1-3) | Third | ½ out |
| Wednesday, May 1 |
| » Defeated Mets (12-7), 10-3 | Shea Stadium (1-1) | 11-10 | |
| » W: Bob Knepper (2-0) L: Ron Darling (1-1) S: Frank DiPino (3) | Third | ½ out |
| Friday, May 3 |
| » Lost to Phillies (9-12), 3-2 | Veteran's Stadium (0-1) | 11-11 | |
| » W: Kent Tekulve (2-0) L: Frank DiPino (1-3) | Third | 1½ out |
| Saturday, May 4 |
| » Lost to Phillies (10-12), 7-5 | Veteran's Stadium (0-2) | 11-12 | Lost 2 |
| » W: Dave Rucker (1-0) L: Bill Dawley (0-2) | Third | 1½ out |
| Sunday, May 5 |
| » Defeated Phillies (10-13), 4-3 | Veteran's Stadium (1-2) | 12-12 | |
| » W: Joe Niekro (2-3) L: Shane Rawley (3-2) S: Frank DiPino (4) | Third | 1 out |
| Tuesday, May 7 |
| » Defeated Expos (15-10), 3-1 | Stade Olympique (1-0) | 13-12 | Won 2 |
| » W: Bob Knepper (3-0) L: David Palmer (2-3) S: Bill Dawley (1) | Second | ½ out |
| Wednesday, May 8 |
| » Lost to Expos (16-10), 1-0 | Stade Olympique (1-1) | 13-13 | |
| » W: Joe Hesketh (4-1) L: Nolan Ryan (2-2) S: Jeff Reardon (8) | Third | 1½ out |
| Friday, May 10 |
| » Lost to Reds (14-13), 5-2 | Riverfront Stadium (0-1) | 13-14 | Lost 2 |
| » W: Tom Browning (3-1) L: Frank DiPino (1-4) S: Ted Power (5) | Fourth | 2 out |
| Saturday, May 11 |
| » Defeated Reds (14-14), 10-7 | Riverfront Stadium (1-1) | 14-14 | |
| » W: Julio Solano (1-0) L: Mario Soto (5-3) S: Dave Smith (4) | Third | 2 out |
| Sunday, May 12 |
| » Defeated Reds (14-15), 10-5 | Riverfront Stadium (2-1) | 15-14 | Won 2 |
| » W: Bob Knepper (4-0) L: Jay Tibbs (2-5) S: Jeff Calhoun (2) | Third | 2 out |
| Monday, May 13 |
| » Defeated Expos (19-11), 3-2 | Astrodome (8-6) | 16-14 | Won 3 |
| » W: Dave Smith (4-1) L: Jeff Reardon (1-1) | Second | 1½ out |
| Tuesday, May 14 |
| » Defeated Expos (19-12), 10-0 | Astrodome (9-6) | 17-14 | Won 4 |
| » W: Ron Mathis (2-1) L: Steve Rogers (2-3) | Second | 1½ out |
| Wednesday, May 15 |
| » Lost to Mets (21-9), 5-3 | Astrodome (9-7) | 17-15 | |
| » W: Dwight Gooden (6-1) L: Joe Niekro (2-4) S: Jesse Orosco (5) | Second | 1½ out |
| Thursday, May 16 |
| » Defeated Mets (21-10), 1-0 | Astrodome (10-7) | 18-15 | |
| » W: Mike Scott (2-1) L: Sid Fernandez (1-1) S: Dave Smith (5) | Second | 1 out |
| Friday, May 17 |
| » Lost to Cardinals (16-17), 8-6 | Astrodome (10-8) | 18-16 | |
| » W: Bill Campbell (1-1) L: Jeff Calhoun (0-1) S: Ken Dayley (2) | Second | 1 out |
| Saturday, May 18 |
| » Defeated Cardinals (16-18), 6-5 | Astrodome (11-8) | 19-16 | |
| » W: Nolan Ryan (3-2) L: Kurt Kepshire (2-4) S: Mark Ross (1) | Second | 1 out |
| Sunday, May 19 |
| » Defeated Cardinals (16-19), 7-3 | Astrodome (12-8) | 20-16 | Won 2 |
| » W: Ron Mathis (3-1) L: John Tudor (1-6) S: Bill Dawley (2) | Second | 1 out |
| Monday, May 20 |
| » Lost to Pirates (11-24), 3-1 | Three Rivers Stadium (0-1) | 20-17 | |
| » W: Rick Rhoden (3-4) L: Joe Niekro (2-5) S: Al Holland (3) | Second | 2 out |
| Tuesday, May 21 |
| » Lost to Pirates (12-24), 3-2 | Three Rivers Stadium (0-2) | 20-18 | Lost 2 |
| » W: Rick Reuschel (1-0) L: Mike Scott (2-2) S: John Candelaria (6) | Third | 2½ out |
| Wednesday, May 22 |
| » Defeated Pirates (12-25), 5-3 | Three Rivers Stadium (1-2) | 21-18 | |
| » W: Bill Dawley (1-2) L: Al Holland (1-2) S: Dave Smith (6) | Second | 2½ out |
| Friday, May 24 |
| » Defeated Cubs (22-15), 6-2 | Wrigley Field (1-0) | 22-18 | Won 2 |
| » W: Nolan Ryan (4-2) L: Dick Ruthven (1-3) | Second | 2½ out |
| Saturday, May 25 |
| » Lost to Cubs (23-15), 5-4 | Wrigley Field (1-1) | 22-19 | |
| » W: Lee Smith (2-0) L: Mark Ross (0-1) | Second | 3½ out |
| Sunday, May 26 |
| » Lost to Cubs (24-15), 10-8 | Wrigley Field (1-2) | 22-20 | Lost 2 |
| » W: George Frazier (2-1) L: Mark Ross (0-2) S: Lee Smith (11) | Second | 4½ out |
| Monday, May 27 |
| » Defeated Pirates (14-27), 4-2 | Astrodome (13-8) | 23-20 | |
| » W: Bob Knepper (5-0) L: Jose DeLeon (0-7) S: Dave Smith (7) | Second | 3½ out |
| Tuesday, May 28 |
| » Lost to Pirates (15-27), 4-3 | Astrodome (13-9) | 23-21 | |
| » W: Cecilio Guante (1-0) L: Julio Solano (1-1) | Second | 3½ out |
| Wednesday, May 29 |
| » Defeated Pirates (15-28), 8-3 | Astrodome (14-9) | 24-21 | |
| » W: Nolan Ryan (5-2) L: Ray Krawczyk (0-2) | Second | 2½ out |
| Friday, May 31 |
| » Lost to Cubs (26-17), 6-2 | Astrodome (14-10) | 24-22 | |
| » W: Lee Smith (3-0) L: Dave Smith (4-2) | Second | 4 out |
| Saturday, June 1 |
| » Lost to Cubs (27-17), 4-1 | Astrodome (14-11) | 24-23 | Lost 2 |
| » W: Dennis Eckersley (7-3) L: Bob Knepper (5-1) | Third | 4 out |
| Sunday, June 2 |
| » Defeated Cubs (27-18), 4-3 | Astrodome (15-11) | 25-23 | |
| » W: Mike Scott (3-2) L: Larry Gura (0-1) S: Dave Smith (8) | Third | 3 out |
| Monday, June 3 |
| » Lost to Cardinals (25-23), 9-5 | Busch Stadium II (0-1) | 25-24 | |
| » W: John Tudor (2-7) L: Nolan Ryan (5-3) S: Ken Dayley (5) | Third | 3 out |
| Tuesday, June 4 |
| » Lost to Cardinals (26-23), 6-1 | Busch Stadium II (0-2) | 25-25 | Lost 2 |
| » W: Joaquin Andujar (10-1) L: Joe Niekro (2-6) | Third | 4 out |
| Wednesday, June 5 |
| » Defeated Cardinals (26-24), 8-3 | Busch Stadium II (1-2) | 26-25 | |
| » W: Bob Knepper (6-1) L: Danny Cox (6-2) S: Frank DiPino (5) | Third | 4 out |
| Friday, June 7 |
| » Defeated Giants (20-31), 4-1 | Astrodome (16-11) | 27-25 | Won 2 |
| » W: Mike Scott (4-2) L: Atlee Hammaker (2-5) S: Dave Smith (9) | Third | 4½ out |
| Saturday, June 8 |
| » Defeated Giants (20-32), 4-1 | Astrodome (17-11) | 28-25 | Won 3 |
| » W: Nolan Ryan (6-3) L: Bill Laskey (1-6) S: Dave Smith (10) | Third | 3½ out |
| » Major-league debuts: Chris Jones (Astros) |
| Sunday, June 9 |
| » Defeated Giants (20-33), 5-0 | Astrodome (18-11) | 29-25 | Won 4 |
| » W: Joe Niekro (3-6) L: Dave LaPoint (2-6) | Second | 3½ out |
| Monday, June 10 |
| » Lost to Padres (33-21), 9-1 | Astrodome (18-12) | 29-26 | |
| » W: La Marr Hoyt (7-4) L: Bob Knepper (6-2) | Second | 4½ out |
| Tuesday, June 11 |
| » Defeated Padres (33-22), 11-0 | Astrodome (19-12) | 30-26 | |
| » W: Mike Scott (5-2) L: Mark Thurmond (3-4) | Second | 3½ out |
| Wednesday, June 12 |
| » Defeated Padres (33-23), 3-2 | Astrodome (20-12) | 31-26 | Won 2 |
| » W: Nolan Ryan (7-3) L: Eric Show (4-4) | Second | 2½ out |
| Friday, June 14 |
| » Lost to Dodgers (29-28), 10-2 | Astrodome (20-13) | 31-27 | |
| » W: Jerry Reuss (4-5) L: Joe Niekro (3-7) | Second | 3 out |
| Saturday, June 15 |
| » Lost to Dodgers (30-28), 3-0 | Astrodome (20-14) | 31-28 | Lost 2 |
| » W: Orel Hershiser (6-1) L: Bob Knepper (6-3) | Second | 4 out |
| Sunday, June 16 |
| » Lost to Dodgers (31-28), 9-0 | Astrodome (20-15) | 31-29 | Lost 3 |
| » W: Fernando Valenzuela (6-7) L: Mike Scott (5-3) | Third | 3½ out |
| Monday, June 17 |
| » Defeated Braves (26-34), 4-3 | Atlanta-Fulton County Stadium (3-1) | 32-29 | |
| » W: Nolan Ryan (8-3) L: Steve Shields (1-1) S: Dave Smith (11) | Second | 3½ out |
| Tuesday, June 18 |
| » Lost to Braves (27-34), 3-2 | Atlanta-Fulton County Stadium (3-2) | 32-30 | |
| » W: Bruce Sutter (4-2) L: Julio Solano (1-2) | Third | 4½ out |
| Wednesday, June 19 |
| » Defeated Braves (27-35), 7-3 | Atlanta-Fulton County Stadium (4-2) | 33-30 | |
| » W: Joe Niekro (4-7) L: Steve Bedrosian (3-6) | Second | 3½ out |
| Thursday, June 20 |
| » Defeated Braves (27-36), 2-0 | Atlanta-Fulton County Stadium (5-2) | 34-30 | Won 2 |
| » W: Bob Knepper (7-3) L: Rick Mahler (10-6) S: Dave Smith (12) | Second | 3½ out |
| Friday, June 21 |
| » Lost to Dodgers (33-30), 7-2 | Dodger Stadium (1-3) | 34-31 | |
| » W: Orel Hershiser (7-1) L: Mike Scott (5-4) | Third | 4½ out |
| Saturday, June 22 |
| » Lost to Dodgers (34-30), 6-3 | Dodger Stadium (1-4) | 34-32 | Lost 2 |
| » W: Fernando Valenzuela (7-7) L: Nolan Ryan (8-4) | Fourth | 5½ out |
| Sunday, June 23 |
| » Lost to Dodgers (35-30), 6-2 | Dodger Stadium (1-5) | 34-33 | Lost 3 |
| » W: Rick Honeycutt (5-6) L: Ron Mathis (3-2) S: Tom Niedenfuer (5) | Fourth | 6½ out |
| Monday, June 24 |
| » Defeated Dodgers (35-31), 8-4 | Dodger Stadium (2-5) | 35-33 | |
| » W: Joe Niekro (5-7) L: Jerry Reuss (5-6) | Third | 6 out |
| Tuesday, June 25 |
| » Lost to Braves (30-38), 6-4 | Astrodome (20-16) | 35-34 | |
| » W: Rick Mahler (11-6) L: Bob Knepper (7-4) S: Bruce Sutter (12) | Fourth | 6 out |
| Wednesday, June 26 |
| » Lost to Braves (31-38), 3-1 | Astrodome (20-17) | 35-35 | Lost 2 |
| » W: Jeff Dedmon (4-0) L: Dave Smith (4-3) S: Bruce Sutter (13) | Third | 7 out |
| Thursday, June 27 |
| » Lost to Braves (32-38), 4-1 | Astrodome (20-18) | 35-36 | Lost 3 |
| » W: Zane Smith (4-4) L: Nolan Ryan (8-5) S: Bruce Sutter (14) | Fourth | 8 out |
| Friday, June 28 |
| » Defeated Giants (26-46), 3-1 | Candlestick Park (1-0) | 36-36 | |
| » W: Joe Niekro (6-7) L: Bill Laskey (1-10) S: Dave Smith (13) | Fourth | 7 out |
| Saturday, June 29 |
| » Defeated Giants (26-47), 8-1 | Candlestick Park (2-0) | 37-36 | Won 2 |
| » W: Bob Knepper (8-4) L: Atlee Hammaker (3-8) | Fourth | 7 out |
| Sunday, June 30 |
| » Defeated Giants (26-48), 6-2 | Candlestick Park (3-0) | 38-36 | Won 3 |
| » W: Mike Scott (6-4) L: Dave LaPoint (3-7) | Fourth | 6½ out |
| » Lost to Giants (27-48), 7-4 | Candlestick Park (3-1) | 38-37 | |
| » W: Vida Blue (4-2) L: Ron Mathis (3-3) S: Mark Davis (4) | Fourth | 6½ out |
| Monday, July 1 |
| » Lost to Padres (45-30), 6-5 | San Diego/Jack Murphy Stadium (0-1) | 38-38 | Lost 2 |
| » W: Rich Gossage (2-1) L: Nolan Ryan (8-6) | Third | 7½ out |
| Tuesday, July 2 |
| » Defeated Padres (45-31), 3-2 | San Diego/Jack Murphy Stadium (1-1) | 39-38 | |
| » W: Joe Niekro (7-7) L: Ed Wojna (1-1) S: Jeff Calhoun (3) | Fourth | 6½ out |
| Thursday, July 4 |
| » Lost to Expos (45-33), 9-3 | Astrodome (20-19) | 39-39 | |
| » W: Randy St.claire (3-1) L: Frank DiPino (1-5) | Fourth | 7½ out |
| Friday, July 5 |
| » Defeated Expos (45-34), 4-2 | Astrodome (21-19) | 40-39 | |
| » W: Mike Scott (7-4) L: Mickey Mahler (1-3) S: Ron Mathis (1) | Fourth | 6½ out |
| Saturday, July 6 |
| » Defeated Expos (45-35), 8-7 | Astrodome (22-19) | 41-39 | Won 2 |
| » W: Jeff Calhoun (1-1) L: Gary Lucas (3-1) S: Dave Smith (14) | Fourth | 5½ out |
| Sunday, July 7 |
| » Lost to Expos (46-35), 6-3 | Astrodome (22-20) | 41-40 | |
| » W: Floyd Youmans (1-0) L: Ron Mathis (3-4) | Fourth | 6½ out |
| Monday, July 8 |
| » Lost to Phillies (36-44), 7-4 | Astrodome (22-21) | 41-41 | Lost 2 |
| » W: Charles Hudson (4-7) L: Mark Knudson (0-1) S: Kent Tekulve (7) | Fourth | 7 out |
| » Major-league debuts: Mark Knudson (Astros) |
| Tuesday, July 9 |
| » Lost to Phillies (37-44), 5-3 | Astrodome (22-22) | 41-42 | Lost 3 |
| » W: Kevin Gross (8-7) L: Bob Knepper (8-5) S: Kent Tekulve (8) | Fourth | 7 out |
| Wednesday, July 10 |
| » Defeated Phillies (37-45), 10-0 | Astrodome (23-22) | 42-42 | |
| » W: Mike Scott (8-4) L: Jerry Koosman (3-2) | Fourth | 6 out |
| Thursday, July 11 |
| » Defeated Mets (47-36), 4-3 | Astrodome (24-22) | 43-42 | Won 2 |
| » W: Dave Smith (5-3) L: Tom Gorman (4-4) | Fourth | 5 out |
| Friday, July 12 |
| » Lost to Mets (48-36), 3-2 | Astrodome (24-23) | 43-43 | |
| » W: Ron Darling (9-2) L: Ron Mathis (3-5) S: Roger McDowell (7) | Fourth | 6 out |
| Saturday, July 13 |
| » Lost to Mets (49-36), 10-1 | Astrodome (24-24) | 43-44 | Lost 2 |
| » W: Ed Lynch (7-5) L: Mark Knudson (0-2) | Fourth | 6½ out |
| Sunday, July 14 |
| » Lost to Mets (50-36), 1-0 | Astrodome (24-25) | 43-45 | Lost 3 |
| » W: Dwight Gooden (13-3) L: Bob Knepper (8-6) | Fourth | 6½ out |
| Thursday, July 18 |
| » Lost to Expos (50-39), 3-0 | Stade Olympique (1-2) | 43-46 | Lost 4 |
| » W: Joe Hesketh (6-4) L: Joe Niekro (7-8) S: Jeff Reardon (23) | Fourth | 7½ out |
| Friday, July 19 |
| » Lost to Expos (51-39), 4-0 | Stade Olympique (1-3) | 43-47 | Lost 5 |
| » W: Bryn Smith (11-3) L: Bob Knepper (8-7) | Fourth | 8½ out |
| Saturday, July 20 |
| » Lost to Expos (52-39), 6-1 | Stade Olympique (1-4) | 43-48 | Lost 6 |
| » W: Bill Gullickson (9-6) L: Nolan Ryan (8-7) | Fourth | 9½ out |
| Sunday, July 21 |
| » Defeated Expos (52-40), 5-4 | Stade Olympique (2-4) | 44-48 | |
| » W: Mike Scott (9-4) L: Mickey Mahler (1-4) S: Dave Smith (15) | Fourth | 8½ out |
| Monday, July 22 |
| » Lost to Phillies (40-51), 7-6 | Veteran's Stadium (1-3) | 44-49 | |
| » W: Don Carman (3-3) L: Jeff Heathcock (0-1) | Fourth | 8½ out |
| Tuesday, July 23 |
| » Lost to Phillies (41-51), 12-6 | Veteran's Stadium (1-4) | 44-50 | Lost 2 |
| » W: Jerry Koosman (5-2) L: Bob Knepper (8-8) | Fourth | 9½ out |
| Wednesday, July 24 |
| » Lost to Phillies (42-51), 3-1 | Veteran's Stadium (1-5) | 44-51 | Lost 3 |
| » W: Kevin Gross (9-8) L: Nolan Ryan (8-8) S: Kent Tekulve (11) | Fourth | 10½ out |
| Thursday, July 25 |
| » Lost to Mets (54-40), 6-3 | Shea Stadium (1-2) | 44-52 | Lost 4 |
| » W: Dwight Gooden (15-3) L: Mike Scott (9-5) | Fourth | 11½ out |
| Saturday, July 27 |
| » Lost to Mets (55-40), 16-4 | Shea Stadium (1-3) | 44-53 | Lost 5 |
| » W: Jesse Orosco (2-4) L: Frank DiPino (1-6) | Fourth | 13½ out |
| » Lost to Mets (56-40), 7-3 | Shea Stadium (1-4) | 44-54 | Lost 6 |
| » W: Bill Latham (1-1) L: Charlie Kerfeld (0-1) S: Jesse Orosco (10) | Fourth | 13½ out |
| » Major-league debuts: Charlie Kerfeld (Astros) |
| Sunday, July 28 |
| » Defeated Mets (56-41), 12-4 | Shea Stadium (2-4) | 45-54 | |
| » W: Joe Niekro (8-8) L: Ron Darling (10-4) | Fourth | 12½ out |
| Tuesday, July 30 |
| » Lost to Reds (52-45), 4-1 | Riverfront Stadium (2-2) | 45-55 | |
| » W: Mario Soto (10-11) L: Nolan Ryan (8-9) | Fourth | 14 out |
| Wednesday, July 31 |
| » Defeated Reds (52-46), 9-2 | Riverfront Stadium (3-2) | 46-55 | |
| » W: Mike Scott (10-5) L: Tom Browning (9-8) | Fourth | 13 out |
| Thursday, August 1 |
| » Lost to Reds (53-46), 5-2 | Riverfront Stadium (3-3) | 46-56 | |
| » W: Andy McGaffigan (1-0) L: Bob Knepper (8-9) | Fourth | 13½ out |
| Friday, August 2 |
| » Defeated Padres (55-48), 12-9 | Astrodome (25-25) | 47-56 | |
| » W: Joe Niekro (9-8) L: La Marr Hoyt (13-6) S: Dave Smith (16) | Fourth | 13 out |
| Saturday, August 3 |
| » Defeated Padres (55-49), 4-3 | Astrodome (26-25) | 48-56 | Won 2 |
| » W: Charlie Kerfeld (1-1) L: Craig Lefferts (6-5) | Fourth | 13 out |
| Sunday, August 4 |
| » Defeated Padres (55-50), 2-1 | Astrodome (27-25) | 49-56 | Won 3 |
| » W: Mike Scott (11-5) L: Dave Dravecky (8-7) S: Dave Smith (17) | Fourth | 12 out |
| Monday, August 5 |
| » Defeated Giants (41-65), 7-5 | Astrodome (28-25) | 50-56 | Won 4 |
| » W: Bob Knepper (9-9) L: Atlee Hammaker (3-10) S: Dave Smith (18) | Fourth | 12 out |
| Thursday, August 8 |
| » Lost to Padres (56-51), 6-5 | San Diego/Jack Murphy Stadium (1-2) | 50-57 | |
| » W: Craig Lefferts (7-5) L: Dave Smith (5-4) | Fourth | 12 out |
| Friday, August 9 |
| » Lost to Padres (57-51), 6-4 | San Diego/Jack Murphy Stadium (1-3) | 50-58 | Lost 2 |
| » W: Dave Dravecky (9-7) L: Nolan Ryan (8-10) S: Gene Walter (1) | Fourth | 13½ out |
| » Lost to Padres (58-51), 2-1 | San Diego/Jack Murphy Stadium (1-4) | 50-59 | Lost 3 |
| » W: Eric Show (8-7) L: Mike Scott (11-6) S: Mark Thurmond (2) | Fourth | 13½ out |
| » Major-league debuts: Gene Walter (Padres) |
| Sunday, August 11 |
| » Defeated Padres (58-52), 7-2 | San Diego/Jack Murphy Stadium (2-4) | 51-59 | |
| » W: Bob Knepper (10-9) L: Andy Hawkins (14-4) | Fourth | 14 out |
| Tuesday, August 13 |
| » Lost to Giants (43-68), 4-2 | Candlestick Park (3-2) | 51-60 | |
| » W: Mike Krukow (8-8) L: Joe Niekro (9-9) | Fourth | 15½ out |
| Wednesday, August 14 |
| » Defeated Giants (43-69), 7-5 | Candlestick Park (4-2) | 52-60 | |
| » W: Jeff Heathcock (1-1) L: Mark Davis (3-7) S: Dave Smith (19) | Fourth | 15½ out |
| Thursday, August 15 |
| » Defeated Giants (43-70), 4-1 | Candlestick Park (5-2) | 53-60 | Won 2 |
| » W: Mike Scott (12-6) L: Dave LaPoint (5-11) | Fourth | 15½ out |
| Friday, August 16 |
| » Defeated Reds (59-54), 5-4 | Astrodome (29-25) | 54-60 | Won 3 |
| » W: Dave Smith (6-4) L: Ted Power (4-3) | Fourth | 15½ out |
| Former Astro Dick Drott dies in Glendale Heights, IL at the age of 50. |
| Saturday, August 17 |
| » Lost to Reds (60-54), 8-0 | Astrodome (29-26) | 54-61 | |
| » W: Tom Browning (11-9) L: Joe Niekro (9-10) | Fourth | 15½ out |
| Sunday, August 18 |
| » Lost to Reds (61-54), 8-3 | Astrodome (29-27) | 54-62 | Lost 2 |
| » W: Jay Tibbs (6-13) L: Nolan Ryan (8-11) S: John Franco (5) | Fourth | 15½ out |
| Tuesday, August 20 |
| » Defeated Cardinals (70-46), 17-2 | Astrodome (30-27) | 55-62 | |
| » W: Mike Scott (13-6) L: Kurt Kepshire (9-7) | Fourth | 15½ out |
| Wednesday, August 21 |
| » Lost to Cardinals (71-46), 7-4 | Astrodome (30-28) | 55-63 | |
| » W: Jeff Lahti (2-1) L: Dave Smith (6-5) | Fourth | 16½ out |
| Thursday, August 22 |
| » Lost to Cardinals (72-46), 2-1 | Astrodome (30-29) | 55-64 | Lost 2 |
| » W: Ricky Horton (2-2) L: Jeff Calhoun (1-2) S: Ken Dayley (10) | Fourth | 16½ out |
| Friday, August 23 |
| » Defeated Pirates (37-81), 2-0 | Three Rivers Stadium (2-2) | 56-64 | |
| » W: Bill Dawley (2-2) L: Pat Clements (5-1) S: Frank DiPino (6) | Fourth | 16½ out |
| Sunday, August 25 |
| » Lost to Pirates (38-81), 9-3 | Three Rivers Stadium (2-3) | 56-65 | |
| » W: Rick Reuschel (10-6) L: Mike Scott (13-7) | Fourth | 16½ out |
| » Lost to Pirates (39-81), 10-9 | Three Rivers Stadium (2-4) | 56-66 | Lost 2 |
| » W: Don Robinson (4-8) L: Jeff Calhoun (1-3) | Fourth | 16½ out |
| Monday, August 26 |
| » Lost to Cubs (61-61), 10-4 | Astrodome (30-30) | 56-67 | Lost 3 |
| » W: Steve Engel (1-2) L: Bob Knepper (10-10) | Fourth | 17½ out |
| » Major-league debuts: Eric Bullock (Astros) |
| Tuesday, August 27 |
| » Defeated Cubs (61-62), 11-4 | Astrodome (31-30) | 57-67 | |
| » W: Dave Smith (7-5) L: Ron Meridith (2-1) | Fourth | 17½ out |
| Wednesday, August 28 |
| » Defeated Cubs (61-63), 3-0 | Astrodome (32-30) | 58-67 | Won 2 |
| » W: Nolan Ryan (9-11) L: Jay Baller (0-2) S: Jeff Heathcock (1) | Fourth | 17 out |
| Friday, August 30 |
| » Defeated Cardinals (77-48), 7-5 | Busch Stadium II (2-2) | 59-67 | Won 3 |
| » W: Mike Scott (14-7) L: Kurt Kepshire (10-8) S: Dave Smith (20) | Fourth | 15½ out |
| Saturday, August 31 |
| » Defeated Cardinals (77-49), 3-1 | Busch Stadium II (3-2) | 60-67 | Won 4 |
| » W: Bob Knepper (11-10) L: Danny Cox (14-8) | Fourth | 14½ out |
| Sunday, September 1 |
| » Lost to Cardinals (78-49), 5-0 | Busch Stadium II (3-3) | 60-68 | |
| » W: John Tudor (16-8) L: Joe Niekro (9-11) | Fourth | 14½ out |
| Monday, September 2 |
| » Defeated Cubs (63-66), 7-2 | Wrigley Field (2-2) | 61-68 | |
| » W: Bill Dawley (3-2) L: Jay Baller (0-3) | Fourth | 14½ out |
| Tuesday, September 3 |
| » Defeated Cubs (63-67), 8-7 | Wrigley Field (3-2) | 62-68 | Won 2 |
| » W: Dave Smith (8-5) L: George Frazier (7-6) | Fourth | 14½ out |
| Wednesday, September 4 |
| » Defeated Cubs (63-68), 11-6 | Wrigley Field (4-2) | 63-68 | Won 3 |
| » W: Mike Scott (15-7) L: Ron Meridith (2-2) | Fourth | 14½ out |
| Thursday, September 5 |
| » Defeated Pirates (42-89), 4-3 | Astrodome (33-30) | 64-68 | Won 4 |
| » W: Bob Knepper (12-10) L: Bob Walk (1-2) S: Dave Smith (21) | Fourth | 14 out |
| Friday, September 6 |
| » Defeated Pirates (42-90), 4-3 | Astrodome (34-30) | 65-68 | Won 5 |
| » W: Bill Dawley (4-2) L: Don Robinson (4-11) | Fourth | 13 out |
| Saturday, September 7 |
| » Lost to Pirates (43-90), 7-1 | Astrodome (34-31) | 65-69 | |
| » W: Lee Tunnell (3-9) L: Charlie Kerfeld (1-2) | Fourth | 14 out |
| Monday, September 9 |
| » Defeated Giants (53-82), 4-2 | Astrodome (35-31) | 66-69 | |
| » W: Mike Scott (16-7) L: Atlee Hammaker (4-11) S: Dave Smith (22) | Fourth | 13½ out |
| Tuesday, September 10 |
| » Defeated Giants (53-83), 4-1 | Astrodome (36-31) | 67-69 | Won 2 |
| » W: Bob Knepper (13-10) L: Mike Krukow (8-11) | Fourth | 14 out |
| Wednesday, September 11 |
| » Lost to Giants (54-83), 11-4 | Astrodome (36-32) | 67-70 | |
| » W: Jim Gott (7-10) L: Joe Niekro (9-12) | Fourth | 14½ out |
| » Defeated Giants (54-84), 10-9 | Astrodome (37-32) | 68-70 | |
| » W: Frank DiPino (2-6) L: Mark Davis (5-9) | Fourth | 14½ out |
| Thursday, September 12 |
| » Defeated Giants (54-85), 5-2 | Astrodome (38-32) | 69-70 | Won 2 |
| » W: Charlie Kerfeld (2-2) L: Dave LaPoint (7-13) | Fourth | 13½ out |
| Friday, September 13 |
| » Defeated Padres (71-69), 3-2 | Astrodome (39-32) | 70-70 | Won 3 |
| » W: Mike Scott (17-7) L: Mark Thurmond (6-9) | Fourth | 13 out |
| Saturday, September 14 |
| » Defeated Padres (71-70), 4-3 | Astrodome (40-32) | 71-70 | Won 4 |
| » W: Bob Knepper (14-10) L: Dave Dravecky (11-10) S: Dave Smith (23) | Third | 13 out |
| Sunday, September 15 |
| » Defeated Padres (71-71), 2-1 | Astrodome (41-32) | 72-70 | Won 5 |
| » W: Jeff Calhoun (2-3) L: Craig Lefferts (7-6) S: Dave Smith (24) | Third | 12 out |
| Monday, September 16 |
| » Defeated Braves (60-83), 7-2 | Atlanta-Fulton County Stadium (6-2) | 73-70 | Won 6 |
| » W: Jeff Heathcock (2-1) L: Joe Johnson (4-1) | Third | 11 out |
| Tuesday, September 17 |
| » Defeated Braves (60-84), 10-6 | Atlanta-Fulton County Stadium (7-2) | 74-70 | Won 7 |
| » W: Frank DiPino (3-6) L: Zane Smith (7-10) | Third | 11 out |
| Wednesday, September 18 |
| » Defeated Dodgers (85-60), 7-2 | Dodger Stadium (3-5) | 75-70 | Won 8 |
| » W: Mike Scott (18-7) L: Ken Howell (4-6) S: Jeff Calhoun (4) | Third | 10 out |
| Thursday, September 19 |
| » Defeated Dodgers (85-61), 6-5 | Dodger Stadium (4-5) | 76-70 | Won 9 |
| » W: Bob Knepper (15-10) L: Bob Welch (11-4) S: Dave Smith (25) | Third | 9 out |
| Friday, September 20 |
| » Lost to Reds (80-66), 5-3 | Astrodome (41-33) | 76-71 | |
| » W: Jay Tibbs (9-15) L: Nolan Ryan (9-12) S: Ted Power (23) | Third | 9 out |
| Saturday, September 21 |
| » Defeated Reds (80-67), 9-5 | Astrodome (42-33) | 77-71 | |
| » W: Dave Smith (9-5) L: John Franco (12-3) | Third | 9 out |
| Sunday, September 22 |
| » Lost to Reds (81-67), 6-5 | Astrodome (42-34) | 77-72 | |
| » W: Ted Power (7-4) L: Bill Dawley (4-3) | Third | 10 out |
| Monday, September 23 |
| » Lost to Dodgers (88-62), 5-3 | Astrodome (42-35) | 77-73 | Lost 2 |
| » W: Carlos Diaz (5-3) L: Jeff Calhoun (2-4) S: Tom Niedenfuer (17) | Third | 11 out |
| Tuesday, September 24 |
| » Lost to Dodgers (89-62), 7-2 | Astrodome (42-36) | 77-74 | Lost 3 |
| » W: Bob Welch (12-4) L: Bob Knepper (15-11) | Third | 12 out |
| Wednesday, September 25 |
| » Defeated Dodgers (89-63), 6-4 | Astrodome (43-36) | 78-74 | |
| » W: Julio Solano (2-2) L: Tom Niedenfuer (7-8) | Third | 11 out |
| Friday, September 27 |
| » Lost to Reds (84-68), 4-3 | Riverfront Stadium (3-4) | 78-75 | |
| » W: Ron Robinson (7-6) L: Jeff Calhoun (2-5) S: John Franco (10) | Third | 12 out |
| Saturday, September 28 |
| » Lost to Reds (85-68), 5-2 | Riverfront Stadium (3-5) | 78-76 | Lost 2 |
| » W: Tom Browning (20-9) L: Mike Scott (18-8) S: Ted Power (26) | Fourth | 13 out |
| Sunday, September 29 |
| » Lost to Reds (86-68), 5-0 | Riverfront Stadium (3-6) | 78-77 | Lost 3 |
| » W: Jay Tibbs (10-15) L: Bob Knepper (15-12) | Fourth | 14 out |
| Monday, September 30 |
| » Lost to Braves (64-92), 6-3 | Astrodome (43-37) | 78-78 | Lost 4 |
| » W: Rick Camp (4-6) L: Frank DiPino (3-7) | Fourth | 14 out |
| Tuesday, October 1 |
| » Defeated Braves (64-93), 2-0 | Astrodome (44-37) | 79-78 | |
| » W: Charlie Kerfeld (3-2) L: Steve Bedrosian (7-15) S: Dave Smith (26) | Fourth | 14 out |
| Wednesday, October 2 |
| » Defeated Giants (60-98), 7-2 | Candlestick Park (6-2) | 80-78 | Won 2 |
| » W: Bill Dawley (5-3) L: Mark Davis (5-12) | Fourth | 14 out |
| Thursday, October 3 |
| » Defeated Giants (60-99), 7-2 | Candlestick Park (7-2) | 81-78 | Won 3 |
| » W: Jeff Heathcock (3-1) L: Dave LaPoint (7-17) | Fourth | 13 out |
| Friday, October 4 |
| » Lost to Padres (83-77), 4-3 | San Diego/Jack Murphy Stadium (2-5) | 81-79 | |
| » W: Mark Thurmond (7-11) L: Bob Knepper (15-13) S: Rich Gossage (26) | Fourth | 13 out |
| Saturday, October 5 |
| » Defeated Padres (83-78), 9-3 | San Diego/Jack Murphy Stadium (3-5) | 82-79 | |
| » W: Nolan Ryan (10-12) L: Ed Wojna (2-4) | Fourth | 13 out |
| Sunday, October 6 |
| » Defeated Padres (83-79), 6-4 | San Diego/Jack Murphy Stadium (4-5) | 83-79 | Won 2 |
| » W: Charlie Kerfeld (4-2) L: Eric Show (12-11) S: Dave Smith (27) | Third | 12 out |
Game information provided by Retrosheet (www.retrosheet.org) |