| Sunday, February 19 |
| Former White Sox Bill Shores dies in Purcell, OK at the age of 80. |
| Sunday, February 26 |
| Former White Sox Joe Kuhel dies in Kansas City, KS at the age of 78. |
| Monday, April 2 |
| » Defeated Orioles (0-1), 5-2 | Memorial Stadium (1-0) | 1-0 | |
| » W: La Marr Hoyt (1-0) L: Scott McGregor (0-1) S: Britt Burns (1) | First | -- |
| Friday, April 6 |
| » Lost to Tigers (3-0), 3-2 | Comiskey Park I (0-1) | 1-1 | |
| » W: Milt Wilcox (1-0) L: Richard Dotson (0-1) S: Willie Hernandez (1) | Third | 1½ out |
| Former White Sox Glenn Wright dies in Olathe, KS at the age of 84. |
| Saturday, April 7 |
| » Lost to Tigers (4-0), 4-0 | Comiskey Park I (0-2) | 1-2 | Lost 2 |
| » W: Jack Morris (2-0) L: Floyd Bannister (0-1) | Third | 1½ out |
| Sunday, April 8 |
| » Lost to Tigers (5-0), 7-3 | Comiskey Park I (0-3) | 1-3 | Lost 3 |
| » W: Aurelio Lopez (1-0) L: Tom Seaver (0-1) | Fifth | 2½ out |
| Tuesday, April 10 |
| » Defeated Indians (3-2), 7-3 | Comiskey Park I (1-3) | 2-3 | |
| » W: La Marr Hoyt (2-0) L: Neal Heaton (1-1) S: Ron Reed (1) | Fourth | 2½ out |
| Wednesday, April 11 |
| » Defeated Indians (3-3), 6-1 | Comiskey Park I (2-3) | 3-3 | Won 2 |
| » W: Richard Dotson (1-1) L: Bert Blyleven (1-1) | Fourth | 2½ out |
| » Major-league debuts: Jerry Willard (Indians) |
| Friday, April 13 |
| » Defeated Yankees (3-6), 5-3 | Yankee Stadium (1-0) | 4-3 | Won 3 |
| » W: Floyd Bannister (1-1) L: John Montefusco (0-1) S: Ron Reed (2) | Fourth | 1½ out |
| Sunday, April 15 |
| » Lost to Yankees (4-6), 2-1 | Yankee Stadium (1-1) | 4-4 | |
| » W: Dave Righetti (1-0) L: Britt Burns (0-1) | Fourth | 2 out |
| » Major-league debuts: Stan Javier (Yankees) |
| Tuesday, April 17 |
| » Lost to Brewers (4-7), 7-3 | County Stadium (0-1) | 4-5 | Lost 2 |
| » W: Moose Haas (1-2) L: Tom Seaver (0-2) S: Pete Ladd (1) | Fourth | 3 out |
| Thursday, April 19 |
| » Defeated Brewers (4-8), 3-1 | County Stadium (1-1) | 5-5 | |
| » W: Richard Dotson (2-1) L: Jaime Cocanower (0-2) | Fourth | 2 out |
| Friday, April 20 |
| » Lost to Tigers (10-1), 3-2 | Tiger Stadium (0-1) | 5-6 | |
| » W: Aurelio Lopez (2-0) L: Ron Reed (0-1) | Sixth | 2½ out |
| Saturday, April 21 |
| » Lost to Tigers (11-1), 4-1 | Tiger Stadium (0-2) | 5-7 | Lost 2 |
| » W: Dave Rozema (1-0) L: La Marr Hoyt (2-1) S: Doug Bair (1) | Sixth | 3 out |
| Sunday, April 22 |
| » Lost to Tigers (12-1), 9-1 | Tiger Stadium (0-3) | 5-8 | Lost 3 |
| » W: Juan Berenguer (1-0) L: Tom Brennan (0-1) | Sixth | 3 out |
| Monday, April 23 |
| » Defeated Orioles (4-12), 7-6 | Comiskey Park I (3-3) | 6-8 | |
| » W: Britt Burns (1-1) L: Tippy Martinez (0-2) | Seventh | 2½ out |
| Tuesday, April 24 |
| » Lost to Orioles (5-12), 8-3 | Comiskey Park I (3-4) | 6-9 | |
| » W: Scott McGregor (2-3) L: Richard Dotson (2-2) | Seventh | 3 out |
| Wednesday, April 25 |
| » Lost to Indians (8-6), 9-2 | Cleveland Stadium (0-1) | 6-10 | Lost 2 |
| » W: Neal Heaton (2-2) L: Floyd Bannister (1-2) | Seventh | 3½ out |
| Thursday, April 26 |
| » Lost to Indians (9-6), 5-4 | Cleveland Stadium (0-2) | 6-11 | Lost 3 |
| » W: George Frazier (1-2) L: Ron Reed (0-2) | Seventh | 4 out |
| Friday, April 27 |
| » Lost to Red Sox (8-12), 5-3 | Comiskey Park I (3-5) | 6-12 | Lost 4 |
| » W: Dennis Eckersley (2-2) L: La Marr Hoyt (2-2) | Seventh | 4½ out |
| Saturday, April 28 |
| » Lost to Red Sox (9-12), 8-7 | Comiskey Park I (3-6) | 6-13 | Lost 5 |
| » W: Mark Clear (2-0) L: Ron Reed (0-3) S: Bob Stanley (3) | Seventh | 5½ out |
| Sunday, April 29 |
| » Defeated Red Sox (9-13), 6-4 | Comiskey Park I (4-6) | 7-13 | |
| » W: Richard Dotson (3-2) L: Al Nipper (0-1) S: Al Jones (1) | Seventh | 5 out |
| Monday, April 30 |
| » Defeated Yankees (8-13), 5-3 | Comiskey Park I (5-6) | 8-13 | Won 2 |
| » W: Floyd Bannister (2-2) L: Ron Guidry (1-2) S: Britt Burns (2) | Sixth | 4½ out |
| Tuesday, May 1 |
| » Defeated Yankees (8-14), 7-5 | Comiskey Park I (6-6) | 9-13 | Won 3 |
| » W: Salome Barojas (1-0) L: Ray Fontenot (0-4) S: Britt Burns (3) | Sixth | 4½ out |
| Wednesday, May 2 |
| » Defeated Yankees (8-15), 3-0 | Comiskey Park I (7-6) | 10-13 | Won 4 |
| » W: La Marr Hoyt (3-2) L: Jose Rijo (0-3) | Sixth | 3½ out |
| Friday, May 4 |
| » Defeated Red Sox (11-15), 5-3 | Fenway Park (1-0) | 11-13 | Won 5 |
| » W: Tom Seaver (1-2) L: Dennis Eckersley (2-3) S: Al Jones (2) | Fifth | 3½ out |
| Saturday, May 5 |
| » Defeated Red Sox (11-16), 8-5 | Fenway Park (2-0) | 12-13 | Won 6 |
| » W: Richard Dotson (4-2) L: Oil Can Boyd (0-3) S: Ron Reed (3) | Fifth | 3½ out |
| Sunday, May 6 |
| » Lost to Red Sox (12-16), 3-1 | Fenway Park (2-1) | 12-14 | |
| » W: Bruce Hurst (4-3) L: Floyd Bannister (2-3) | Fourth | 3½ out |
| Monday, May 7 |
| » Lost to Brewers (13-13), 7-3 | Comiskey Park I (7-7) | 12-15 | Lost 2 |
| » W: Jaime Cocanower (1-4) L: La Marr Hoyt (3-3) | Fifth | 3½ out |
| Wednesday, May 9 |
| » Defeated Brewers (13-14), 7-6 | Comiskey Park I (8-7) | 13-15 | |
| » W: Tom Seaver (2-2) L: Chuck Porter (2-1) | Fifth | 2 out |
| » Defeated Brewers (13-15), 5-4 | Comiskey Park I (9-7) | 14-15 | Won 2 |
| » W: Tom Seaver (3-2) L: Mike Caldwell (4-2) S: Salome Barojas (1) | Fifth | 2 out |
| Thursday, May 10 |
| » Defeated Rangers (10-21), 8-6 | Comiskey Park I (10-7) | 15-15 | Won 3 |
| » W: Salome Barojas (2-0) L: Odell Jones (1-1) | Fourth | 1½ out |
| Friday, May 11 |
| » Lost to Rangers (11-21), 6-1 | Comiskey Park I (10-8) | 15-16 | |
| » W: Frank Tanana (3-4) L: Floyd Bannister (2-4) | Fourth | 1½ out |
| Saturday, May 12 |
| » Lost to Rangers (12-21), 6-4 | Comiskey Park I (10-9) | 15-17 | Lost 2 |
| » W: Dave Stewart (1-6) L: La Marr Hoyt (3-4) S: Dave Tobik (3) | Fourth | 2½ out |
| Sunday, May 13 |
| » Defeated Rangers (12-22), 8-1 | Comiskey Park I (11-9) | 16-17 | |
| » W: Britt Burns (2-1) L: Charlie Hough (2-5) | Third | 1½ out |
| » Major-league debuts: Daryl Boston (White Sox) |
| Monday, May 14 |
| » Defeated Royals (12-19), 2-0 | Comiskey Park I (12-9) | 17-17 | Won 2 |
| » W: Tom Seaver (4-2) L: Bret Saberhagen (1-2) | Third | 1 out |
| Tuesday, May 15 |
| » Defeated Royals (12-20), 3-2 | Comiskey Park I (13-9) | 18-17 | Won 3 |
| » W: Richard Dotson (5-2) L: Danny Jackson (0-5) | Third | 1½ out |
| Wednesday, May 16 |
| » Lost to Royals (13-20), 7-6 | Comiskey Park I (13-10) | 18-18 | |
| » W: Joe Beckwith (1-1) L: Salome Barojas (2-1) S: Dan Quisenberry (10) | Second | 1½ out |
| Thursday, May 17 |
| » Lost to Blue Jays (22-13), 3-2 | Exhibition Stadium (0-1) | 18-19 | Lost 2 |
| » W: Roy Lee Jackson (4-1) L: La Marr Hoyt (3-5) S: Dennis Lamp (6) | Third | 1 out |
| Friday, May 18 |
| » Lost to Blue Jays (23-13), 4-3 | Exhibition Stadium (0-2) | 18-20 | Lost 3 |
| » W: Jim Clancy (3-3) L: Britt Burns (2-2) S: Jimmy Key (2) | Third | 2 out |
| Saturday, May 19 |
| » Lost to Blue Jays (24-13), 1-0 | Exhibition Stadium (0-3) | 18-21 | Lost 4 |
| » W: Jim Gott (2-2) L: Tom Seaver (4-3) S: Dennis Lamp (7) | Fourth | 3 out |
| Sunday, May 20 |
| » Defeated Blue Jays (24-14), 3-0 | Exhibition Stadium (1-3) | 19-21 | |
| » W: Richard Dotson (6-2) L: Dave Stieb (5-1) | Third | 3 out |
| Monday, May 21 |
| » Defeated Royals (14-23), 8-4 | Royals Stadium (1-0) | 20-21 | Won 2 |
| » W: Floyd Bannister (3-4) L: Larry Gura (5-2) | Third | 2½ out |
| Tuesday, May 22 |
| » Lost to Royals (15-23), 7-6 | Royals Stadium (1-1) | 20-22 | |
| » W: Joe Beckwith (2-1) L: Salome Barojas (2-2) S: Dan Quisenberry (11) | Third | 2½ out |
| Wednesday, May 23 |
| » Lost to Royals (16-23), 1-0 | Royals Stadium (1-2) | 20-23 | Lost 2 |
| » W: Bud Black (5-3) L: Britt Burns (2-3) | Third | 2½ out |
| Friday, May 25 |
| » Lost to Rangers (18-26), 11-0 | Arlington Stadium (0-1) | 20-24 | Lost 3 |
| » W: Charlie Hough (3-6) L: Tom Seaver (4-4) | Fourth | 3 out |
| Saturday, May 26 |
| » Defeated Rangers (18-27), 5-1 | Arlington Stadium (1-1) | 21-24 | |
| » W: Richard Dotson (7-2) L: Mike Mason (2-3) | Fourth | 2 out |
| Sunday, May 27 |
| » Lost to Rangers (19-27), 11-3 | Arlington Stadium (1-2) | 21-25 | |
| » W: Danny Darwin (4-2) L: Floyd Bannister (3-5) | Fourth | 2 out |
| Tuesday, May 29 |
| » Defeated Blue Jays (31-15), 8-1 | Comiskey Park I (14-10) | 22-25 | |
| » W: La Marr Hoyt (4-5) L: Jim Clancy (4-4) | Fourth | 2½ out |
| Wednesday, May 30 |
| » Lost to Blue Jays (32-15), 2-1 | Comiskey Park I (14-11) | 22-26 | |
| » W: Dave Stieb (7-1) L: Britt Burns (2-4) S: Jimmy Key (4) | Fourth | 2½ out |
| Friday, June 1 |
| » Defeated Athletics (23-28), 6-4 | Comiskey Park I (15-11) | 23-26 | |
| » W: Juan Agosto (1-0) L: Lary Sorensen (1-8) | Fourth | 2½ out |
| Saturday, June 2 |
| » Lost to Athletics (24-28), 6-3 | Comiskey Park I (15-12) | 23-27 | |
| » W: Ray Burris (5-2) L: Richard Dotson (7-3) S: Bill Caudill (11) | Fifth | 3½ out |
| Sunday, June 3 |
| » Defeated Athletics (24-29), 3-2 | Comiskey Park I (16-12) | 24-27 | |
| » W: Bert Roberge (1-0) L: Jeff Jones (0-1) | Third | 3½ out |
| Monday, June 4 |
| » Defeated Angels (29-26), 6-4 | Comiskey Park I (17-12) | 25-27 | Won 2 |
| » W: La Marr Hoyt (5-5) L: Ron Romanick (6-5) S: Al Jones (3) | Third | 2½ out |
| Tuesday, June 5 |
| » Lost to Angels (30-26), 6-1 | Comiskey Park I (17-13) | 25-28 | |
| » W: Geoff Zahn (6-3) L: Britt Burns (2-5) | Fourth | 3½ out |
| Wednesday, June 6 |
| » Defeated Angels (30-27), 4-0 | Comiskey Park I (18-13) | 26-28 | |
| » W: Tom Seaver (5-4) L: Mike Witt (5-6) | Fourth | 2½ out |
| Thursday, June 7 |
| » Defeated Angels (30-28), 11-10 | Comiskey Park I (19-13) | 27-28 | Won 2 |
| » W: Bert Roberge (2-0) L: Tommy John (3-4) S: Al Jones (4) | Third | 1½ out |
| Friday, June 8 |
| » Defeated Twins (27-30), 6-1 | Comiskey Park I (20-13) | 28-28 | Won 3 |
| » W: Floyd Bannister (4-5) L: Frank Viola (4-7) | Second | 1 out |
| Saturday, June 9 |
| » Defeated Twins (27-31), 8-4 | Comiskey Park I (21-13) | 29-28 | Won 4 |
| » W: La Marr Hoyt (6-5) L: John Butcher (4-4) S: Al Jones (5) | Second | 1 out |
| Sunday, June 10 |
| » Lost to Twins (28-31), 12-5 | Comiskey Park I (21-14) | 29-29 | |
| » W: Ed Hodge (3-2) L: Britt Burns (2-6) | Second | 2 out |
| Tuesday, June 12 |
| » Lost to Angels (33-28), 3-2 | Anaheim Stadium (0-1) | 29-30 | Lost 2 |
| » W: Doug Corbett (2-0) L: Al Jones (0-1) | Second | 3 out |
| Wednesday, June 13 |
| » Defeated Angels (33-29), 2-1 | Anaheim Stadium (1-1) | 30-30 | |
| » W: Richard Dotson (8-3) L: Tommy John (3-5) | Second | 2 out |
| Thursday, June 14 |
| » Lost to Angels (34-29), 9-3 | Anaheim Stadium (1-2) | 30-31 | |
| » W: Ron Romanick (8-5) L: Britt Burns (2-7) S: Doug Corbett (3) | Second | 3 out |
| Friday, June 15 |
| » Lost to Athletics (29-35), 2-1 | Oakland-Alameda County Stadium (0-1) | 30-32 | Lost 2 |
| » W: Keith Atherton (5-3) L: La Marr Hoyt (6-6) | Second | 4 out |
| Saturday, June 16 |
| » Lost to Athletics (30-35), 6-4 | Oakland-Alameda County Stadium (0-2) | 30-33 | Lost 3 |
| » W: Steve McCatty (4-5) L: Floyd Bannister (4-6) S: Bill Caudill (14) | Third | 5 out |
| Sunday, June 17 |
| » Defeated Athletics (30-36), 9-4 | Oakland-Alameda County Stadium (1-2) | 31-33 | |
| » W: Tom Seaver (6-4) L: Jeff Jones (0-3) S: Juan Agosto (1) | Third | 4 out |
| Monday, June 18 |
| » Defeated Mariners (32-36), 8-4 | Kingdome (1-0) | 32-33 | Won 2 |
| » W: Richard Dotson (9-3) L: Matt Young (4-5) | Second | 3 out |
| Tuesday, June 19 |
| » Lost to Mariners (33-36), 8-2 | Kingdome (1-1) | 32-34 | |
| » W: Jim Beattie (6-7) L: Britt Burns (2-8) | Second | 3 out |
| Wednesday, June 20 |
| » Defeated Mariners (33-37), 5-4 | Kingdome (2-1) | 33-34 | |
| » W: La Marr Hoyt (7-6) L: Mark Langston (4-6) S: Juan Agosto (2) | Second | 2 out |
| Friday, June 22 |
| » Defeated Twins (33-36), 8-6 | Hubert H. Humphrey Metrodome (1-0) | 34-34 | Won 2 |
| » W: Dan Spillner (1-5) L: Ron Davis (3-5) | Second | 2 out |
| Saturday, June 23 |
| » Lost to Twins (34-36), 4-3 | Hubert H. Humphrey Metrodome (1-1) | 34-35 | |
| » W: Len Whitehouse (1-1) L: Tom Seaver (6-5) S: Ron Davis (13) | Second | 2 out |
| Sunday, June 24 |
| » Lost to Twins (35-36), 3-2 | Hubert H. Humphrey Metrodome (1-2) | 34-36 | Lost 2 |
| » W: Ken Schrom (1-2) L: Richard Dotson (9-4) | Third | 2 out |
| Monday, June 25 |
| » Lost to Mariners (34-40), 6-1 | Comiskey Park I (21-15) | 34-37 | Lost 3 |
| » W: Jim Beattie (7-7) L: Britt Burns (2-9) | Third | 2 out |
| Tuesday, June 26 |
| » Lost to Mariners (35-40), 5-0 | Comiskey Park I (21-16) | 34-38 | Lost 4 |
| » W: Mark Langston (5-6) L: La Marr Hoyt (7-7) | Fourth | 3 out |
| Wednesday, June 27 |
| » Defeated Mariners (35-41), 9-7 | Comiskey Park I (22-16) | 35-38 | |
| » W: Salome Barojas (3-2) L: Edwin Nunez (1-1) | Fourth | 3 out |
| Thursday, June 28 |
| » Lost to Orioles (42-33), 2-0 | Comiskey Park I (22-17) | 35-39 | |
| » W: Mike Flanagan (8-5) L: Tom Seaver (6-6) S: Tippy Martinez (11) | Fourth | 4 out |
| Friday, June 29 |
| » Defeated Orioles (42-34), 2-1 | Comiskey Park I (23-17) | 36-39 | |
| » W: Richard Dotson (10-4) L: Dennis Martinez (1-4) | Fourth | 3 out |
| Saturday, June 30 |
| » Defeated Orioles (42-35), 5-4 | Comiskey Park I (24-17) | 37-39 | Won 2 |
| » W: Al Jones (1-1) L: Sammy Stewart (4-1) | Second | 3 out |
| Sunday, July 1 |
| » Lost to Orioles (43-35), 8-3 | Comiskey Park I (24-18) | 37-40 | |
| » W: Mike Boddicker (10-6) L: La Marr Hoyt (7-8) | Third | 4 out |
| Monday, July 2 |
| » Defeated Tigers (55-23), 7-1 | Comiskey Park I (25-18) | 38-40 | |
| » W: Floyd Bannister (5-6) L: Dave Rozema (4-1) | Third | 4 out |
| » Major-league debuts: Doug Baker (Tigers) |
| Tuesday, July 3 |
| » Defeated Tigers (55-24), 9-5 | Comiskey Park I (26-18) | 39-40 | Won 2 |
| » W: Tom Seaver (7-6) L: Jack Morris (12-5) S: Ron Reed (4) | Third | 3 out |
| Wednesday, July 4 |
| » Defeated Tigers (55-25), 8-2 | Comiskey Park I (27-18) | 40-40 | Won 3 |
| » W: Richard Dotson (11-4) L: Milt Wilcox (8-6) | Second | 2 out |
| Thursday, July 5 |
| » Defeated Indians (33-46), 7-6 | Comiskey Park I (28-18) | 41-40 | Won 4 |
| » W: Gene Nelson (1-0) L: Neal Heaton (5-8) | Second | 1 out |
| Friday, July 6 |
| » Defeated Indians (33-47), 11-6 | Comiskey Park I (29-18) | 42-40 | Won 5 |
| » W: La Marr Hoyt (8-8) L: Don Schulze (1-2) S: Ron Reed (5) | Second | 1 out |
| Saturday, July 7 |
| » Defeated Indians (33-48), 4-2 | Comiskey Park I (30-18) | 43-40 | Won 6 |
| » W: Floyd Bannister (6-6) L: Roy Smith (2-2) S: Gene Nelson (1) | First | -- |
| Sunday, July 8 |
| » Defeated Indians (33-49), 9-8 | Comiskey Park I (31-18) | 44-40 | Won 7 |
| » W: Juan Agosto (2-0) L: Steve Farr (0-5) | First | -- |
| Thursday, July 12 |
| » Lost to Orioles (47-39), 2-1 | Memorial Stadium (1-1) | 44-41 | |
| » W: Storm Davis (7-4) L: La Marr Hoyt (8-9) S: Sammy Stewart (3) | Third | ½ out |
| » Lost to Orioles (48-39), 3-0 | Memorial Stadium (1-2) | 44-42 | Lost 2 |
| » W: Scott McGregor (11-7) L: Gene Nelson (1-1) | Third | ½ out |
| Friday, July 13 |
| » Lost to Orioles (49-39), 7-5 | Memorial Stadium (1-3) | 44-43 | Lost 3 |
| » W: Tippy Martinez (4-5) L: Ron Reed (0-4) | Third | ½ out |
| Saturday, July 14 |
| » Defeated Orioles (49-40), 3-2 | Memorial Stadium (2-3) | 45-43 | |
| » W: Tom Seaver (8-6) L: Mike Flanagan (9-7) | Second | ½ out |
| Sunday, July 15 |
| » Lost to Orioles (50-40), 6-4 | Memorial Stadium (2-4) | 45-44 | |
| » W: Dennis Martinez (3-5) L: Richard Dotson (11-5) S: Tippy Martinez (13) | Second | 1½ out |
| Monday, July 16 |
| » Lost to Tigers (61-28), 7-1 | Tiger Stadium (0-4) | 45-45 | Lost 2 |
| » W: Glenn Abbott (3-2) L: La Marr Hoyt (8-10) | Second | 2½ out |
| Tuesday, July 17 |
| » Lost to Tigers (62-28), 3-2 | Tiger Stadium (0-5) | 45-46 | Lost 3 |
| » W: Dan Petry (12-4) L: Gene Nelson (1-2) S: Willie Hernandez (17) | Second | 3½ out |
| Wednesday, July 18 |
| » Defeated Tigers (62-29), 10-6 | Tiger Stadium (1-5) | 46-46 | |
| » W: Floyd Bannister (7-6) L: Jack Morris (12-6) S: Juan Agosto (3) | Second | 2½ out |
| Thursday, July 19 |
| » Defeated Indians (39-52), 3-0 | Cleveland Stadium (1-2) | 47-46 | Won 2 |
| » W: Tom Seaver (9-6) L: Steve Farr (1-6) S: Jerry Don Gleaton (1) | Second | 2 out |
| Friday, July 20 |
| » Lost to Indians (40-52), 6-3 | Cleveland Stadium (1-3) | 47-47 | |
| » W: Roy Smith (3-2) L: Richard Dotson (11-6) | Second | 2 out |
| Saturday, July 21 |
| » Defeated Indians (40-53), 4-3 | Cleveland Stadium (2-3) | 48-47 | |
| » W: Jerry Don Gleaton (1-0) L: Tom Waddell (2-3) S: Ron Reed (6) | Second | 1 out |
| Sunday, July 22 |
| » Lost to Indians (41-53), 4-1 | Cleveland Stadium (2-4) | 48-48 | |
| » W: Neal Heaton (7-9) L: Gene Nelson (1-3) | Second | 1 out |
| Monday, July 23 |
| » Major-league debuts: Jeff Kunkel (Rangers) |
| Tuesday, July 24 |
| » Lost to Red Sox (49-46), 3-2 | Fenway Park (2-2) | 48-49 | Lost 2 |
| » W: Oil Can Boyd (5-7) L: Floyd Bannister (7-7) S: Bob Stanley (16) | Third | 1½ out |
| Wednesday, July 25 |
| » Lost to Red Sox (50-46), 3-2 | Fenway Park (2-3) | 48-50 | Lost 3 |
| » W: Mark Clear (6-2) L: Jerry Don Gleaton (1-1) | Third | 2½ out |
| Thursday, July 26 |
| » Lost to Red Sox (51-46), 7-0 | Fenway Park (2-4) | 48-51 | Lost 4 |
| » W: Roger Clemens (4-4) L: Richard Dotson (11-7) | Third | 3 out |
| Friday, July 27 |
| » Lost to Yankees (47-51), 8-6 | Comiskey Park I (31-19) | 48-52 | Lost 5 |
| » W: Mike Armstrong (2-0) L: La Marr Hoyt (8-11) S: Dave Righetti (14) | Third | 3 out |
| Saturday, July 28 |
| » Lost to Yankees (48-51), 3-2 | Comiskey Park I (31-20) | 48-53 | Lost 6 |
| » W: Ron Guidry (9-8) L: Gene Nelson (1-4) S: Dave Righetti (15) | Third | 3½ out |
| Sunday, July 29 |
| » Defeated Yankees (48-52), 5-4 | Comiskey Park I (32-20) | 49-53 | |
| » W: Floyd Bannister (8-7) L: Marty Bystrom (6-5) S: Ron Reed (7) | Third | 3½ out |
| Monday, July 30 |
| » Defeated Red Sox (53-49), 7-0 | Comiskey Park I (33-20) | 50-53 | Won 2 |
| » W: Tom Seaver (10-6) L: Al Nipper (3-4) | Third | 3½ out |
| Tuesday, July 31 |
| » Lost to Red Sox (54-49), 14-4 | Comiskey Park I (33-21) | 50-54 | |
| » W: Roger Clemens (5-4) L: Richard Dotson (11-8) | Third | 4½ out |
| Wednesday, August 1 |
| » Defeated Red Sox (54-50), 5-3 | Comiskey Park I (34-21) | 51-54 | |
| » W: La Marr Hoyt (9-11) L: Bob Ojeda (9-8) | Third | 3½ out |
| Friday, August 3 |
| » Defeated Brewers (47-62), 5-1 | County Stadium (2-1) | 52-54 | Won 2 |
| » W: Floyd Bannister (9-7) L: Don Sutton (10-9) | Third | 3 out |
| Saturday, August 4 |
| » Defeated Brewers (47-63), 7-3 | County Stadium (3-1) | 53-54 | Won 3 |
| » W: Tom Seaver (11-6) L: Moose Haas (6-9) S: Jerry Don Gleaton (2) | Third | 2½ out |
| Sunday, August 5 |
| » Defeated Brewers (47-64), 7-0 | County Stadium (4-1) | 54-54 | Won 4 |
| » W: Richard Dotson (12-8) L: Mike Caldwell (4-10) | Third | 2 out |
| Monday, August 6 |
| » Defeated Brewers (47-65), 5-3 | County Stadium (5-1) | 55-54 | Won 5 |
| » W: Gene Nelson (2-4) L: Jaime Cocanower (7-12) S: Juan Agosto (4) | Third | 2 out |
| Tuesday, August 7 |
| » Defeated Yankees (56-53), 6-3 | Yankee Stadium (2-1) | 56-54 | Won 6 |
| » W: La Marr Hoyt (10-11) L: Jim Deshaies (0-1) S: Juan Agosto (5) | Third | 2½ out |
| » Lost to Yankees (57-53), 7-0 | Yankee Stadium (2-2) | 56-55 | |
| » W: Ron Guidry (10-8) L: Jerry Don Gleaton (1-2) | Third | 2½ out |
| » Major-league debuts: Jim Deshaies (Yankees) |
| Wednesday, August 8 |
| » Defeated Yankees (57-54), 5-4 | Yankee Stadium (3-2) | 57-55 | |
| » W: Floyd Bannister (10-7) L: Phil Niekro (13-6) S: Ron Reed (8) | Third | 1½ out |
| Thursday, August 9 |
| » Lost to Yankees (58-54), 7-6 | Yankee Stadium (3-3) | 57-56 | |
| » W: Dennis Rasmussen (7-3) L: Tom Seaver (11-7) S: Dave Righetti (20) | Third | 1½ out |
| Friday, August 10 |
| » Lost to Brewers (49-67), 4-2 | Comiskey Park I (34-22) | 57-57 | Lost 2 |
| » W: Mike Caldwell (5-10) L: Richard Dotson (12-9) S: Tom Tellmann (3) | Third | 2½ out |
| Saturday, August 11 |
| » Lost to Brewers (50-67), 10-5 | Comiskey Park I (34-23) | 57-58 | Lost 3 |
| » W: Jaime Cocanower (8-12) L: Gene Nelson (2-5) | Third | 2½ out |
| Sunday, August 12 |
| » Lost to Brewers (51-67), 8-1 | Comiskey Park I (34-24) | 57-59 | Lost 4 |
| » W: Bob McClure (3-5) L: La Marr Hoyt (10-12) | Third | 3½ out |
| Monday, August 13 |
| » Defeated Rangers (50-68), 5-3 | Comiskey Park I (35-24) | 58-59 | |
| » W: Floyd Bannister (11-7) L: Danny Darwin (6-8) S: Juan Agosto (6) | Third | 3½ out |
| Tuesday, August 14 |
| » Lost to Rangers (51-68), 9-3 | Comiskey Park I (35-25) | 58-60 | |
| » W: Frank Tanana (12-11) L: Tom Seaver (11-8) | Third | 4½ out |
| Former White Sox Lynn McGlothen dies in Dubach, LA at the age of 35. |
| Wednesday, August 15 |
| » Lost to Rangers (52-68), 6-5 | Comiskey Park I (35-26) | 58-61 | Lost 2 |
| » W: Charlie Hough (13-10) L: Richard Dotson (12-10) S: Dave Schmidt (8) | Third | 4½ out |
| Friday, August 17 |
| » Lost to Blue Jays (69-52), 4-3 | Comiskey Park I (35-27) | 58-62 | Lost 3 |
| » W: Jim Clancy (10-12) L: La Marr Hoyt (10-13) | Fifth | 5 out |
| Saturday, August 18 |
| » Defeated Blue Jays (69-53), 7-6 | Comiskey Park I (36-27) | 59-62 | |
| » W: Bert Roberge (3-0) L: Roy Lee Jackson (7-6) S: Juan Agosto (7) | Fourth | 5½ out |
| Sunday, August 19 |
| » Lost to Blue Jays (70-53), 7-4 | Comiskey Park I (36-28) | 59-63 | |
| » W: Jimmy Key (4-5) L: Juan Agosto (2-1) | Fourth | 5½ out |
| Monday, August 20 |
| » Defeated Rangers (54-71), 7-5 | Arlington Stadium (2-2) | 60-63 | |
| » W: Richard Dotson (13-10) L: Charlie Hough (13-11) S: Ron Reed (9) | Third | 5 out |
| Tuesday, August 21 |
| » Lost to Rangers (55-71), 4-3 | Arlington Stadium (2-3) | 60-64 | |
| » W: Tom Henke (1-0) L: Bert Roberge (3-1) | Third | 5½ out |
| Wednesday, August 22 |
| » Lost to Rangers (56-71), 3-1 | Arlington Stadium (2-4) | 60-65 | Lost 2 |
| » W: Danny Darwin (7-9) L: La Marr Hoyt (10-14) S: Dave Schmidt (10) | Third | 7 out |
| Thursday, August 23 |
| Former White Sox Charlie Robertson dies in Fort Worth, TX at the age of 89. |
| Friday, August 24 |
| » Lost to Royals (63-64), 5-2 | Royals Stadium (1-3) | 60-66 | Lost 3 |
| » W: Bud Black (13-10) L: Floyd Bannister (11-8) S: Dan Quisenberry (34) | Third | 6½ out |
| Saturday, August 25 |
| » Defeated Royals (63-65), 3-0 | Royals Stadium (2-3) | 61-66 | |
| » W: Tom Seaver (12-8) L: Mark Gubicza (9-10) | Third | 6½ out |
| Sunday, August 26 |
| » Lost to Royals (64-65), 6-5 | Royals Stadium (2-4) | 61-67 | |
| » W: Larry Gura (12-9) L: Bert Roberge (3-2) | Fourth | 6½ out |
| Monday, August 27 |
| » Lost to Royals (65-65), 7-4 | Royals Stadium (2-5) | 61-68 | Lost 2 |
| » W: Bret Saberhagen (7-9) L: La Marr Hoyt (10-15) S: Dan Quisenberry (35) | Fourth | 6½ out |
| Tuesday, August 28 |
| » Lost to Blue Jays (75-56), 7-6 | Exhibition Stadium (1-4) | 61-69 | Lost 3 |
| » W: Bryan Clark (1-1) L: Ron Reed (0-5) | Fourth | 7½ out |
| Wednesday, August 29 |
| » Defeated Blue Jays (75-57), 8-5 | Exhibition Stadium (2-4) | 62-69 | |
| » W: Floyd Bannister (12-8) L: Luis Leal (13-4) S: Dan Spillner (2) | Fourth | 6½ out |
| Thursday, August 30 |
| » Lost to Blue Jays (76-57), 4-3 | Comiskey Park I (36-29) | 62-70 | |
| » W: Jim Gott (7-6) L: Tom Seaver (12-9) S: Jimmy Key (7) | Fourth | 6½ out |
| Friday, August 31 |
| » Lost to Royals (67-67), 3-1 | Comiskey Park I (36-30) | 62-71 | Lost 2 |
| » W: Charlie Leibrandt (8-6) L: Richard Dotson (13-11) S: Dan Quisenberry (36) | Fourth | 6½ out |
| Saturday, September 1 |
| » Defeated Royals (67-68), 6-1 | Comiskey Park I (37-30) | 63-71 | |
| » W: La Marr Hoyt (11-15) L: Bret Saberhagen (7-10) | Fourth | 5½ out |
| Sunday, September 2 |
| » Lost to Royals (68-68), 6-4 | Comiskey Park I (37-31) | 63-72 | |
| » W: Dan Quisenberry (5-3) L: Britt Burns (2-10) S: Mark Huismann (3) | Fourth | 5½ out |
| Monday, September 3 |
| » Lost to Athletics (64-74), 8-2 | Comiskey Park I (37-32) | 63-73 | Lost 2 |
| » W: Chris Codiroli (2-3) L: Floyd Bannister (12-9) | Fifth | 6½ out |
| Tuesday, September 4 |
| » Defeated Athletics (64-75), 12-2 | Comiskey Park I (38-32) | 64-73 | |
| » W: Tom Seaver (13-9) L: Steve McCatty (7-13) | Fourth | 5½ out |
| Wednesday, September 5 |
| » Lost to Athletics (65-75), 5-4 | Comiskey Park I (38-33) | 64-74 | |
| » W: Ray Burris (12-7) L: Richard Dotson (13-12) S: Bill Caudill (28) | Third | 5½ out |
| Thursday, September 6 |
| » Defeated Athletics (65-76), 7-3 | Comiskey Park I (39-33) | 65-74 | |
| » W: La Marr Hoyt (12-15) L: Curt Young (7-4) | Third | 5 out |
| Friday, September 7 |
| » Lost to Angels (70-69), 16-8 | Comiskey Park I (39-34) | 65-75 | |
| » W: Geoff Zahn (11-9) L: Britt Burns (2-11) | Third | 6 out |
| Saturday, September 8 |
| » Lost to Angels (71-69), 6-5 | Comiskey Park I (39-35) | 65-76 | Lost 2 |
| » W: Luis Sanchez (9-6) L: Ron Reed (0-6) | Fourth | 7 out |
| Sunday, September 9 |
| » Defeated Angels (71-70), 8-2 | Comiskey Park I (40-35) | 66-76 | |
| » W: Tom Seaver (14-9) L: Mike Witt (12-11) | Fourth | 7 out |
| Monday, September 10 |
| » Lost to Athletics (67-78), 1-0 | Oakland-Alameda County Stadium (1-3) | 66-77 | |
| » W: Ray Burris (13-7) L: Richard Dotson (13-13) S: Bill Caudill (30) | Third | 7 out |
| Former White Sox Johnny Marcum dies in Louisville, KY at the age of 76. |
| Tuesday, September 11 |
| » Lost to Athletics (68-78), 4-1 | Oakland-Alameda County Stadium (1-4) | 66-78 | Lost 2 |
| » W: Curt Young (8-4) L: La Marr Hoyt (12-16) S: Bill Caudill (31) | Fifth | 8 out |
| Wednesday, September 12 |
| » Defeated Athletics (68-79), 4-2 | Oakland-Alameda County Stadium (2-4) | 67-78 | |
| » W: Britt Burns (3-11) L: Tim Conroy (1-6) S: Ron Reed (10) | Fourth | 7 out |
| Thursday, September 13 |
| » Major-league debuts: John Christensen (Mets) |
| Friday, September 14 |
| » Lost to Angels (73-72), 5-0 | Anaheim Stadium (1-3) | 67-79 | |
| » W: Geoff Zahn (12-9) L: Floyd Bannister (12-10) | Third | 7 out |
| Saturday, September 15 |
| » Lost to Angels (74-72), 11-2 | Anaheim Stadium (1-4) | 67-80 | Lost 2 |
| » W: Mike Witt (13-11) L: Tom Seaver (14-10) | Third | 8 out |
| Sunday, September 16 |
| » Lost to Angels (75-72), 4-2 | Anaheim Stadium (1-5) | 67-81 | Lost 3 |
| » W: Ron Ro |
