| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Tuesday, April 3 |
| » Lost to Tigers (1-0), 8-1 | Hubert H. Humphrey Metrodome (0-1) | 0-1 | |
| » W: Jack Morris (1-0) L: Albert Williams (0-1) | Third | 1 out |
| » Major-league debuts: Keith Comstock (Twins) Barbaro Garbey and Dwight Lowry (Tigers) |
| Wednesday, April 4 |
| » Major-league debuts: Bret Saberhagen (Royals) |
| Thursday, April 5 |
| » Lost to Tigers (2-0), 7-3 | Hubert H. Humphrey Metrodome (0-2) | 0-2 | Lost 2 |
| » W: Dan Petry (1-0) L: Frank Viola (0-1) | Sixth | 2 out |
| » Major-league debuts: Jeff Reed (Twins) |
| Friday, April 6 |
| » Defeated Orioles (0-2), 9-4 | Hubert H. Humphrey Metrodome (1-2) | 1-2 | |
| » W: Mike Smithson (1-0) L: Mike Boddicker (0-1) | Fifth | 2 out |
| Saturday, April 7 |
| » Defeated Orioles (0-3), 13-4 | Hubert H. Humphrey Metrodome (2-2) | 2-2 | Won 2 |
| » W: John Butcher (1-0) L: Mike Flanagan (0-1) | Second | 1 out |
| Sunday, April 8 |
| » Defeated Orioles (0-4), 7-3 | Hubert H. Humphrey Metrodome (3-2) | 3-2 | Won 3 |
| » W: Albert Williams (1-1) L: Jim Palmer (0-1) S: Ron Davis (1) | Second | 1 out |
| Tuesday, April 10 |
| » Lost to Yankees (3-4), 4-1 | Yankee Stadium (0-1) | 3-3 | |
| » W: Phil Niekro (2-0) L: Frank Viola (0-2) S: Dave Righetti (2) | Third | 2 out |
| Thursday, April 12 |
| » Defeated Yankees (3-5), 3-0 | Yankee Stadium (1-1) | 4-3 | |
| » W: Mike Smithson (2-0) L: Ray Fontenot (0-2) S: Ron Davis (2) | Third | 2 out |
| Friday, April 13 |
| » Defeated Mariners (6-2), 4-3 | Hubert H. Humphrey Metrodome (4-2) | 5-3 | Won 2 |
| » W: Ron Davis (1-0) L: Mike Stanton (1-1) | Third | 1 out |
| Saturday, April 14 |
| » Defeated Mariners (6-3), 4-3 | Hubert H. Humphrey Metrodome (5-2) | 6-3 | Won 3 |
| » W: Ron Davis (2-0) L: Bob Stoddard (0-1) | Second | ½ out |
| Sunday, April 15 |
| » Lost to Mariners (7-3), 5-4 | Hubert H. Humphrey Metrodome (5-3) | 6-4 | |
| » W: Roy Thomas (1-0) L: Mike Walters (0-1) S: Dave Beard (2) | Third | 1 out |
| Monday, April 16 |
| » Defeated Angels (5-8), 9-2 | Hubert H. Humphrey Metrodome (6-3) | 7-4 | |
| » W: Mike Smithson (3-0) L: Ron Romanick (1-1) | Second | ½ out |
| Tuesday, April 17 |
| » Lost to Angels (6-8), 6-3 | Hubert H. Humphrey Metrodome (6-4) | 7-5 | |
| » W: Tommy John (1-1) L: John Butcher (1-1) S: Luis Sanchez (2) | Second | 1½ out |
| Wednesday, April 18 |
| » Lost to Angels (7-8), 9-2 | Hubert H. Humphrey Metrodome (6-5) | 7-6 | Lost 2 |
| » W: Geoff Zahn (2-0) L: Albert Williams (1-2) | Third | 1½ out |
| Friday, April 20 |
| » Lost to Orioles (3-10), 4-2 | Memorial Stadium (0-1) | 7-7 | Lost 3 |
| » W: Sammy Stewart (2-0) L: Ron Davis (2-1) | Fourth | 2 out |
| Saturday, April 21 |
| » Lost to Orioles (4-10), 5-3 | Memorial Stadium (0-2) | 7-8 | Lost 4 |
| » W: Mike Flanagan (1-2) L: Mike Smithson (3-1) S: Tippy Martinez (1) | Fifth | 2½ out |
| Sunday, April 22 |
| » Defeated Orioles (4-11), 6-1 | Memorial Stadium (1-2) | 8-8 | |
| » W: John Butcher (2-1) L: Mike Boddicker (0-3) | Fifth | 1½ out |
| Tuesday, April 24 |
| » Lost to Tigers (13-1), 6-5 | Tiger Stadium (0-1) | 8-9 | |
| » W: Jack Morris (4-0) L: Ron Davis (2-2) | Sixth | 2½ out |
| » Lost to Tigers (14-1), 4-3 | Tiger Stadium (0-2) | 8-10 | Lost 2 |
| » W: Glenn Abbott (1-0) L: Frank Viola (0-3) S: Aurelio Lopez (1) | Sixth | 2½ out |
| Wednesday, April 25 |
| » Defeated Yankees (7-9), 8-6 | Hubert H. Humphrey Metrodome (7-5) | 9-10 | |
| » W: Pete Filson (1-0) L: Jay Howell (0-1) S: Mike Walters (1) | Fifth | 2 out |
| Thursday, April 26 |
| » Defeated Yankees (7-10), 4-2 | Hubert H. Humphrey Metrodome (8-5) | 10-10 | Won 2 |
| » W: Pete Filson (2-0) L: Jose Rijo (0-2) S: Mike Walters (2) | Fourth | 1½ out |
| Friday, April 27 |
| » Lost to Athletics (12-9), 5-3 | Oakland-Alameda County Stadium (0-1) | 10-11 | |
| » W: Steve McCatty (3-1) L: Larry Pashnick (0-1) S: Bill Caudill (4) | Fourth | 2 out |
| Saturday, April 28 |
| » Lost to Athletics (13-9), 7-0 | Oakland-Alameda County Stadium (0-2) | 10-12 | Lost 2 |
| » W: Ray Burris (2-0) L: Albert Williams (1-3) | Fourth | 3 out |
| Sunday, April 29 |
| » Defeated Athletics (13-10), 5-2 | Oakland-Alameda County Stadium (1-2) | 11-12 | |
| » W: Frank Viola (1-3) L: Lary Sorensen (1-4) S: Ron Davis (3) | Fourth | 3 out |
| » Lost to Athletics (14-10), 3-0 | Oakland-Alameda County Stadium (1-3) | 11-13 | |
| » W: Chris Codiroli (1-0) L: Mike Smithson (3-2) S: Bill Caudill (5) | Fourth | 3 out |
| Tuesday, May 1 |
| » Lost to Mariners (13-11), 11-8 | Kingdome (0-1) | 11-14 | Lost 2 |
| » W: Dave Beard (2-0) L: Mike Walters (0-2) | Fifth | 4 out |
| Wednesday, May 2 |
| » Defeated Mariners (13-12), 8-6 | Kingdome (1-1) | 12-14 | |
| » W: Larry Pashnick (1-1) L: Ed Vande Berg (1-1) S: Ron Davis (4) | Fourth | 3 out |
| Thursday, May 3 |
| » Lost to Mariners (14-12), 6-2 | Kingdome (1-2) | 12-15 | |
| » W: Mark Langston (2-2) L: Mike Smithson (3-3) S: Dave Beard (3) | Fourth | 3½ out |
| Friday, May 4 |
| » Defeated Athletics (15-12), 3-1 | Hubert H. Humphrey Metrodome (9-5) | 13-15 | |
| » W: Frank Viola (2-3) L: Ray Burris (2-1) S: Ron Davis (5) | Fourth | 3½ out |
| Saturday, May 5 |
| » Defeated Athletics (15-13), 5-4 | Hubert H. Humphrey Metrodome (10-5) | 14-15 | Won 2 |
| » W: Larry Pashnick (2-1) L: Chris Codiroli (1-1) | Fourth | 3½ out |
| Sunday, May 6 |
| » Defeated Athletics (15-14), 4-3 | Hubert H. Humphrey Metrodome (11-5) | 15-15 | Won 3 |
| » W: Ed Hodge (1-0) L: Mike Warren (3-4) S: Ron Davis (6) | Third | 2½ out |
| Monday, May 7 |
| » Defeated Angels (18-14), 11-1 | Anaheim Stadium (1-0) | 16-15 | Won 4 |
| » W: Mike Smithson (4-3) L: Ron Romanick (3-3) | Third | 1½ out |
| Tuesday, May 8 |
| » Defeated Angels (18-15), 5-0 | Anaheim Stadium (2-0) | 17-15 | Won 5 |
| » W: Frank Viola (3-3) L: Jim Slaton (1-1) | Third | ½ out |
| » Major-league debuts: Kirby Puckett (Twins) |
| Wednesday, May 9 |
| » Defeated Angels (18-16), 5-2 | Anaheim Stadium (3-0) | 18-15 | Won 6 |
| » W: Pete Filson (3-0) L: Geoff Zahn (4-2) | First | -- |
| Friday, May 11 |
| » Lost to Brewers (14-15), 4-1 | County Stadium (0-1) | 18-16 | |
| » W: Moose Haas (2-2) L: Ed Hodge (1-1) S: Rollie Fingers (5) | First | -- |
| Saturday, May 12 |
| » Defeated Brewers (14-16), 4-2 | County Stadium (1-1) | 19-16 | |
| » W: Mike Smithson (5-3) L: Mike Caldwell (4-3) S: Ron Davis (7) | First | -- |
| Sunday, May 13 |
| » Lost to Brewers (15-16), 4-1 | County Stadium (1-2) | 19-17 | |
| » W: Jaime Cocanower (2-4) L: Frank Viola (3-4) S: Rollie Fingers (6) | First | -- |
| Tuesday, May 15 |
| » Lost to Blue Jays (20-13), 5-2 | Hubert H. Humphrey Metrodome (11-6) | 19-18 | Lost 2 |
| » W: Roy Lee Jackson (3-1) L: Ron Davis (2-3) | Second | ½ out |
| Wednesday, May 16 |
| » Lost to Blue Jays (21-13), 8-7 | Hubert H. Humphrey Metrodome (11-7) | 19-19 | Lost 3 |
| » W: Doyle Alexander (2-1) L: Pete Filson (3-1) S: Jim Acker (1) | Third | ½ out |
| Friday, May 18 |
| » Defeated Red Sox (16-22), 8-3 | Hubert H. Humphrey Metrodome (12-7) | 20-19 | |
| » W: Mike Smithson (6-3) L: Mike Brown (1-5) | Second | ½ out |
| Saturday, May 19 |
| » Defeated Red Sox (16-23), 7-0 | Hubert H. Humphrey Metrodome (13-7) | 21-19 | Won 2 |
| » W: Frank Viola (4-4) L: Bob Ojeda (4-3) | Second | ½ out |
| Sunday, May 20 |
| » Lost to Red Sox (17-23), 5-4 | Hubert H. Humphrey Metrodome (13-8) | 21-20 | |
| » W: Roger Clemens (1-0) L: John Butcher (2-2) S: Bob Stanley (8) | Second | 1½ out |
| Monday, May 21 |
| » Lost to Blue Jays (25-14), 3-2 | Exhibition Stadium (0-1) | 21-21 | Lost 2 |
| » W: Doyle Alexander (3-1) L: Ron Davis (2-4) | Second | 2 out |
| Tuesday, May 22 |
| » Lost to Blue Jays (26-14), 3-2 | Exhibition Stadium (0-2) | 21-22 | Lost 3 |
| » W: Roy Lee Jackson (5-1) L: Mike Smithson (6-4) | Second | 2 out |
| Wednesday, May 23 |
| » Lost to Blue Jays (27-14), 4-1 | Exhibition Stadium (0-3) | 21-23 | Lost 4 |
| » W: Jim Clancy (4-3) L: Frank Viola (4-5) S: Dennis Lamp (8) | Second | 2 out |
| Friday, May 25 |
| » Defeated Brewers (19-22), 7-4 | Hubert H. Humphrey Metrodome (14-8) | 22-23 | |
| » W: John Butcher (3-2) L: Jaime Cocanower (3-5) S: Ron Davis (8) | Second | 1½ out |
| Saturday, May 26 |
| » Defeated Brewers (19-23), 7-6 | Hubert H. Humphrey Metrodome (15-8) | 23-23 | Won 2 |
| » W: Pete Filson (4-1) L: Rick Waits (0-1) | Second | ½ out |
| Sunday, May 27 |
| » Lost to Brewers (20-23), 5-4 | Hubert H. Humphrey Metrodome (15-9) | 23-24 | |
| » W: Chuck Porter (5-1) L: Mike Smithson (6-5) S: Rollie Fingers (9) | Second | ½ out |
| Wednesday, May 30 |
| » Lost to Red Sox (21-26), 2-0 | Fenway Park (0-1) | 23-25 | Lost 2 |
| » W: Bob Ojeda (5-4) L: John Butcher (3-3) | Second | 1½ out |
| Thursday, May 31 |
| » Defeated Royals (20-26), 7-2 | Hubert H. Humphrey Metrodome (16-9) | 24-25 | |
| » W: Ed Hodge (2-1) L: Mark Gubicza (2-4) S: Ron Davis (9) | Second | 1 out |
| Friday, June 1 |
| » Lost to Royals (21-26), 7-1 | Hubert H. Humphrey Metrodome (16-10) | 24-26 | |
| » W: Charlie Leibrandt (1-0) L: Mike Smithson (6-6) | Second | 2 out |
| Saturday, June 2 |
| » Lost to Royals (22-26), 7-6 | Hubert H. Humphrey Metrodome (16-11) | 24-27 | Lost 2 |
| » W: Dan Quisenberry (3-2) L: Len Whitehouse (0-1) | Third | 3 out |
| Sunday, June 3 |
| » Lost to Royals (23-26), 5-2 | Hubert H. Humphrey Metrodome (16-12) | 24-28 | Lost 3 |
| » W: Bud Black (6-3) L: Frank Viola (4-6) S: Joe Beckwith (1) | Fifth | 4 out |
| Monday, June 4 |
| » Defeated Rangers (20-33), 6-2 | Hubert H. Humphrey Metrodome (17-12) | 25-28 | |
| » W: John Butcher (4-3) L: Dave Stewart (3-7) S: Ron Davis (10) | Fourth | 3 out |
| Tuesday, June 5 |
| » Lost to Rangers (21-33), 2-1 | Hubert H. Humphrey Metrodome (17-13) | 25-29 | |
| » W: Charlie Hough (5-6) L: Ed Hodge (2-2) | Sixth | 4 out |
| Wednesday, June 6 |
| » Defeated Rangers (21-34), 2-1 | Hubert H. Humphrey Metrodome (18-13) | 26-29 | |
| » W: Mike Smithson (7-6) L: Mike Mason (2-4) | Fifth | 3 out |
| Thursday, June 7 |
| » Defeated Rangers (21-35), 5-4 | Hubert H. Humphrey Metrodome (19-13) | 27-29 | Won 2 |
| » W: Ron Davis (3-4) L: Danny Darwin (4-3) | Fourth | 2 out |
| Friday, June 8 |
| » Lost to White Sox (28-28), 6-1 | Comiskey Park I (0-1) | 27-30 | |
| » W: Floyd Bannister (4-5) L: Frank Viola (4-7) | Fourth | 2½ out |
| Saturday, June 9 |
| » Lost to White Sox (29-28), 8-4 | Comiskey Park I (0-2) | 27-31 | Lost 2 |
| » W: La Marr Hoyt (6-5) L: John Butcher (4-4) S: Al Jones (5) | Fourth | 3½ out |
| Sunday, June 10 |
| » Defeated White Sox (29-29), 12-5 | Comiskey Park I (1-2) | 28-31 | |
| » W: Ed Hodge (3-2) L: Britt Burns (2-6) | Third | 3½ out |
| Tuesday, June 12 |
| » Lost to Rangers (26-35), 6-2 | Arlington Stadium (0-1) | 28-32 | |
| » W: Danny Darwin (5-3) L: Mike Smithson (7-7) | Fourth | 4½ out |
| Wednesday, June 13 |
| » Lost to Rangers (27-35), 3-0 | Arlington Stadium (0-2) | 28-33 | Lost 2 |
| » W: Frank Tanana (7-6) L: Ken Schrom (0-1) | Fifth | 4½ out |
| Thursday, June 14 |
| » Defeated Rangers (27-36), 3-2 | Arlington Stadium (1-2) | 29-33 | |
| » W: Frank Viola (5-7) L: Dave Stewart (3-8) S: Ron Davis (11) | Fourth | 4½ out |
| Friday, June 15 |
| » Defeated Royals (27-32), 3-0 | Royals Stadium (1-0) | 30-33 | Won 2 |
| » W: John Butcher (5-4) L: Mark Gubicza (3-6) | Fourth | 4½ out |
| Saturday, June 16 |
| » Defeated Royals (27-33), 6-1 | Royals Stadium (2-0) | 31-33 | Won 3 |
| » W: Albert Williams (2-3) L: Bret Saberhagen (2-7) S: Pete Filson (1) | Second | 4½ out |
| Sunday, June 17 |
| » Defeated Royals (27-34), 3-1 | Royals Stadium (3-0) | 32-33 | Won 4 |
| » W: Mike Smithson (8-7) L: Charlie Leibrandt (2-1) S: Ron Davis (12) | Second | 3½ out |
| Tuesday, June 19 |
| » Lost to Indians (24-38), 7-4 | Hubert H. Humphrey Metrodome (19-14) | 32-34 | |
| » W: Bert Blyleven (5-3) L: Ken Schrom (0-2) S: Ernie Camacho (9) | Second | 3 out |
| Wednesday, June 20 |
| » Defeated Indians (24-39), 8-2 | Hubert H. Humphrey Metrodome (20-14) | 33-34 | |
| » W: Frank Viola (6-7) L: Steve Comer (1-1) | Second | 2 out |
| Thursday, June 21 |
| » Lost to Indians (25-39), 7-0 | Hubert H. Humphrey Metrodome (20-15) | 33-35 | |
| » W: Neal Heaton (5-6) L: John Butcher (5-5) | Third | 2½ out |
| Friday, June 22 |
| » Lost to White Sox (34-34), 8-6 | Hubert H. Humphrey Metrodome (20-16) | 33-36 | Lost 2 |
| » W: Dan Spillner (1-5) L: Ron Davis (3-5) | Third | 3½ out |
| Saturday, June 23 |
| » Defeated White Sox (34-35), 4-3 | Hubert H. Humphrey Metrodome (21-16) | 34-36 | |
| » W: Len Whitehouse (1-1) L: Tom Seaver (6-5) S: Ron Davis (13) | Third | 2½ out |
| Sunday, June 24 |
| » Defeated White Sox (34-36), 3-2 | Hubert H. Humphrey Metrodome (22-16) | 35-36 | Won 2 |
| » W: Ken Schrom (1-2) L: Richard Dotson (9-4) | Second | 1½ out |
| Tuesday, June 26 |
| » Defeated Indians (28-40), 8-3 | Cleveland Stadium (1-0) | 36-36 | Won 3 |
| » W: Frank Viola (7-7) L: Steve Comer (1-2) S: Ron Davis (14) | Second | 1 out |
| Wednesday, June 27 |
| » Lost to Indians (29-40), 6-4 | Cleveland Stadium (1-1) | 36-37 | |
| » W: Ernie Camacho (3-7) L: Ron Davis (3-6) | Second | 2 out |
| Friday, June 29 |
| » Defeated Tigers (53-21), 5-3 | Tiger Stadium (1-2) | 37-37 | |
| » W: Albert Williams (3-3) L: Jack Morris (12-4) S: Ron Davis (15) | Second | 2 out |
| » Lost to Tigers (54-21), 7-5 | Tiger Stadium (1-3) | 37-38 | |
| » W: Willie Hernandez (4-0) L: Pete Filson (4-2) | Second | 2 out |
| » Major-league debuts: Andre David (Twins) |
| Saturday, June 30 |
| » Lost to Tigers (55-21), 4-3 | Tiger Stadium (1-4) | 37-39 | Lost 2 |
| » W: Dan Petry (11-3) L: Ken Schrom (1-3) S: Willie Hernandez (14) | Second | 3 out |
| Sunday, July 1 |
| » Defeated Tigers (55-22), 9-0 | Tiger Stadium (2-4) | 38-39 | |
| » W: Frank Viola (8-7) L: Juan Berenguer (4-6) | Second | 3 out |
| Monday, July 2 |
| » Defeated Orioles (43-36), 6-4 | Hubert H. Humphrey Metrodome (23-16) | 39-39 | Won 2 |
| » W: John Butcher (6-5) L: Scott McGregor (9-7) | Second | 3 out |
| Tuesday, July 3 |
| » Defeated Orioles (43-37), 3-1 | Hubert H. Humphrey Metrodome (24-16) | 40-39 | Won 3 |
| » W: Mike Smithson (9-7) L: Mike Flanagan (8-6) | Second | 2 out |
| Wednesday, July 4 |
| » Lost to Orioles (44-37), 6-4 | Hubert H. Humphrey Metrodome (24-17) | 40-40 | |
| » W: Dennis Martinez (2-4) L: Albert Williams (3-4) S: Tippy Martinez (12) | Second | 2 out |
| Thursday, July 5 |
| » Defeated Yankees (35-44), 5-4 | Hubert H. Humphrey Metrodome (25-17) | 41-40 | |
| » W: Ken Schrom (2-3) L: Ron Guidry (6-7) S: Ron Davis (16) | Second | 1 out |
| Friday, July 6 |
| » Defeated Yankees (35-45), 9-4 | Hubert H. Humphrey Metrodome (26-17) | 42-40 | Won 2 |
| » W: Frank Viola (9-7) L: Bob Shirley (1-3) | Second | 1 out |
| Saturday, July 7 |
| » Lost to Yankees (36-45), 11-4 | Hubert H. Humphrey Metrodome (26-18) | 42-41 | |
| » W: Dennis Rasmussen (2-3) L: John Butcher (6-6) | Third | 1 out |
| » Major-league debuts: Mike Pagliarulo (Yankees) |
| Sunday, July 8 |
| » Defeated Yankees (36-46), 4-3 | Hubert H. Humphrey Metrodome (27-18) | 43-41 | |
| » W: Ron Davis (4-6) L: Dave Righetti (2-2) | Third | 1 out |
| Thursday, July 12 |
| » Defeated Tigers (57-28), 4-2 | Hubert H. Humphrey Metrodome (28-18) | 44-41 | Won 2 |
| » W: Frank Viola (10-7) L: Dan Petry (11-4) S: Ron Davis (17) | First | -- |
| Friday, July 13 |
| » Lost to Tigers (58-28), 5-3 | Hubert H. Humphrey Metrodome (28-19) | 44-42 | |
| » W: Willie Hernandez (5-0) L: Rick Lysander (0-1) S: Aurelio Lopez (10) | First | -- |
| Saturday, July 14 |
| » Lost to Tigers (59-28), 6-5 | Hubert H. Humphrey Metrodome (28-20) | 44-43 | Lost 2 |
| » W: Willie Hernandez (6-0) L: Mike Walters (0-3) | Third | 1 out |
| Sunday, July 15 |
| » Lost to Tigers (60-28), 6-2 | Hubert H. Humphrey Metrodome (28-21) | 44-44 | Lost 3 |
| » W: Dave Rozema (6-1) L: Ken Schrom (2-4) S: Aurelio Lopez (11) | Third | 2 out |
| Monday, July 16 |
| » Lost to Orioles (51-40), 3-1 | Memorial Stadium (1-3) | 44-45 | Lost 4 |
| » W: Storm Davis (8-4) L: Mike Smithson (9-8) | Third | 3 out |
| Tuesday, July 17 |
| » Lost to Orioles (52-40), 3-1 | Memorial Stadium (1-4) | 44-46 | Lost 5 |
| » W: Scott McGregor (12-7) L: Frank Viola (10-8) | Third | 4 out |
| Wednesday, July 18 |
| » Defeated Orioles (52-41), 3-1 | Memorial Stadium (2-4) | 45-46 | |
| » W: John Butcher (7-6) L: Mike Boddicker (10-8) | Third | 3 out |
| Thursday, July 19 |
| » Defeated Yankees (43-48), 2-1 | Yankee Stadium (2-1) | 46-46 | Won 2 |
| » W: Len Whitehouse (2-1) L: Dave Righetti (2-3) S: Ron Davis (18) | Third | 2½ out |
| Friday, July 20 |
| » Lost to Yankees (44-48), 4-3 | Yankee Stadium (2-2) | 46-47 | |
| » W: Jay Howell (4-4) L: Ron Davis (4-7) | Third | 2½ out |
| Saturday, July 21 |
| » Defeated Yankees (44-49), 5-2 | Yankee Stadium (3-2) | 47-47 | |
| » W: Mike Smithson (10-8) L: Ray Fontenot (3-6) S: Rick Lysander (1) | Third | 1½ out |
| Sunday, July 22 |
| » Lost to Yankees (45-49), 6-5 | Yankee Stadium (3-3) | 47-48 | |
| » W: Joe Cowley (1-0) L: Frank Viola (10-9) | Third | 1½ out |
| Monday, July 23 |
| » Defeated Athletics (47-53), 14-4 | Hubert H. Humphrey Metrodome (29-21) | 48-48 | |
| » W: John Butcher (8-6) L: Ray Burris (9-5) | Second | 1½ out |
| Tuesday, July 24 |
| » Defeated Athletics (47-54), 6-4 | Hubert H. Humphrey Metrodome (30-21) | 49-48 | Won 2 |
| » W: Pete Filson (5-2) L: Steve McCatty (7-7) S: Len Whitehouse (1) | Second | ½ out |
| Wednesday, July 25 |
| » Lost to Athletics (48-54), 1-0 | Hubert H. Humphrey Metrodome (30-22) | 49-49 | |
| » W: Curt Young (3-1) L: Ken Schrom (2-5) S: Bill Caudill (21) | Second | 1½ out |
| Friday, July 27 |
| » Defeated Angels (51-49), 2-0 | Hubert H. Humphrey Metrodome (31-22) | 50-49 | |
| » W: Mike Smithson (11-8) L: Tommy John (5-9) S: Ron Davis (19) | Second | ½ out |
| Saturday, July 28 |
| » Defeated Angels (51-50), 6-1 | Hubert H. Humphrey Metrodome (32-22) | 51-49 | Won 2 |
| » W: Frank Viola (11-9) L: Jim Slaton (3-5) | First | -- |
| Sunday, July 29 |
| » Defeated Angels (51-51), 6-5 | Hubert H. Humphrey Metrodome (33-22) | 52-49 | Won 3 |
| » W: Rick Lysander (1-1) L: Luis Sanchez (7-3) | First | -- |
| Monday, July 30 |
| » Defeated Mariners (49-57), 9-5 | Hubert H. Humphrey Metrodome (34-22) | 53-49 | Won 4 |
| » W: Pete Filson (6-2) L: Jim Beattie (9-11) | First | -- |
| Tuesday, July 31 |
| » Defeated Mariners (49-58), 9-2 | Hubert H. Humphrey Metrodome (35-22) | 54-49 | Won 5 |
| » W: Ken Schrom (3-5) L: Ed Vande Berg (7-10) | First | -- |
| Wednesday, August 1 |
| » Lost to Mariners (50-58), 5-1 | Hubert H. Humphrey Metrodome (35-23) | 54-50 | |
| » W: Salome Barojas (7-3) L: Mike Smithson (11-9) | First | -- |
| Thursday, August 2 |
| » Lost to Angels (55-51), 14-2 | Anaheim Stadium (3-1) | 54-51 | Lost 2 |
| » W: Jim Slaton (4-5) L: Frank Viola (11-10) | Second | ½ out |
| Friday, August 3 |
| » Defeated Angels (55-52), 4-2 | Anaheim Stadium (4-1) | 55-51 | |
| » W: John Butcher (9-6) L: Mike Witt (11-8) S: Ron Davis (20) | First | -- |
| Saturday, August 4 |
| » Lost to Angels (56-52), 4-2 | Anaheim Stadium (4-2) | 55-52 | |
| » W: Geoff Zahn (10-8) L: Pete Filson (6-3) S: Bruce Kison (2) | Second | ½ out |
| Sunday, August 5 |
| » Defeated Angels (56-53), 4-2 | Anaheim Stadium (5-2) | 56-52 | |
| » W: Ken Schrom (4-5) L: Ron Romanick (10-10) S: Ron Davis (21) | First | -- |
| Monday, August 6 |
| » Defeated Athletics (52-61), 7-4 | Oakland-Alameda County Stadium (2-3) | 57-52 | Won 2 |
| » W: Mike Smithson (12-9) L: Bill Krueger (7-9) S: Ron Davis (22) | First | -- |
| Tuesday, August 7 |
| » Defeated Athletics (52-62), 2-1 | Oakland-Alameda County Stadium (3-3) | 58-52 | Won 3 |
| » W: Frank Viola (12-10) L: Steve McCatty (7-9) | First | -- |
| Wednesday, August 8 |
| » Lost to Athletics (53-62), 5-0 | Oakland-Alameda County Stadium (3-4) | 58-53 | |
| » W: Ray Burris (11-6) L: John Butcher (9-7) S: Bill Caudill (25) | First | -- |
| Thursday, August 9 |
| » Lost to Mariners (52-64), 6-5 | Kingdome (1-3) | 58-54 | Lost 2 |
| » W: Mike Stanton (4-2) L: Ron Davis (4-8) | First | -- |
| Friday, August 10 |
| » Defeated Mariners (52-65), 13-7 | Kingdome (2-3) | 59-54 | |
| » W: Rick Lysander (2-1) L: Ed Vande Berg (7-12) | First | -- |
| » Major-league debuts: Ivan Calderon (Mariners) |
| Saturday, August 11 |
| » Lost to Mariners (53-65), 5-4 | Kingdome (2-4) | 59-55 | |
| » W: Edwin Nunez (2-1) L: Pete Filson (6-4) | First | -- |
| Sunday, August 12 |
| » Defeated Mariners (53-66), 3-0 | Kingdome (3-4) | 60-55 | |
| » W: Frank Viola (13-10) L: Mike Moore (5-11) | First | -- |
| Monday, August 13 |
| » Defeated Brewers (51-68), 5-1 | Hubert H. Humphrey Metrodome (36-23) | 61-55 | Won 2 |
| » W: John Butcher (10-7) L: Don Sutton (11-10) | First | -- |
| Tuesday, August 14 |
| » Defeated Brewers (51-69), 3-2 | Hubert H. Humphrey Metrodome (37-23) | 62-55 | Won 3 |
| » W: Ed Hodge (4-2) L: Moose Haas (6-10) S: Ron Davis (23) | First | -- |
| Wednesday, August 15 |
| » Lost to Brewers (52-69), 8-4 | Hubert H. Humphrey Metrodome (37-24) | 62-56 | |
| » W: Mike Caldwell (6-10) L: Ken Schrom (4-6) S: Tom Tellmann (4) | First | -- |
| Thursday, August 16 |
| » Lost to Red Sox (63-57), 7-5 | Fenway Park (0-2) | 62-57 | Lost 2 |
| » W: Steve Crawford (4-0) L: Ron Davis (4-9) S: Mark Clear (6) | First | -- |
| Friday, August 17 |
| » Defeated Red Sox (63-58), 6-5 | Fenway Park (1-2) | 63-57 | |
| » W: Frank Viola (14-10) L: Bruce Hurst (11-7) S: Ron Davis (24) | First | -- |
| Saturday, August 18 |
| » Defeated Red Sox (63-59), 6-4 | Fenway Park (2-2) | 64-57 | Won 2 |
| » W: Ron Davis (5-9) L: Bob Stanley (7-9) S: Rick Lysander (2) | First | -- |
| » Defeated Red Sox (63-60), 3-1 | Fenway Park (3-2) | 65-57 | Won 3 |
| » W: Bobby Castillo (1-0) L: John Henry Johnson (0-2) S: Rick Lysander (3) | First | -- |
| Sunday, August 19 |
| » Lost to Red Sox (64-60), 5-4 | Fenway Park (3-3) | 65-58 | |
| » W: Steve Crawford (5-0) L: Len Whitehouse (2-2) S: Bob Stanley (18) | First | -- |
| Wednesday, August 22 |
| » Defeated Brewers (52-73), 5-2 | County Stadium (2-2) | 66-58 | |
| » W: Mike Smithson (13-9) L: Mike Caldwell (6-11) | First | -- |
| » Defeated Brewers (52-74), 4-3 | County Stadium (3-2) | 67-58 | Won 2 |
| » W: Rick Lysander (3-1) L: Ray Searage (0-1) S: Ron Davis (25) | First | -- |
| Thursday, August 23 |
| » Lost to Brewers (53-74), 5-2 | County Stadium (3-3) | 67-59 | |
| » W: Bob McClure (4-5) L: Frank Viola (14-11) | First | -- |
| Friday, August 24 |
| » Lost to Blue Jays (72-55), 6-2 | Hubert H. Humphrey Metrodome (37-25) | 67-60 | Lost 2 |
| » W: Luis Leal (13-3) L: Rick Lysander (3-2) S: Jimmy Key (5) | First | -- |
| Saturday, August 25 |
| » Defeated Blue Jays (72-56), 5-4 | Hubert H. Humphrey Metrodome (38-25) | 68-60 | |
| » W: Bobby Castillo (2-0) L: Jim Gott (6-6) | First | -- |
| Sunday, August 26 |
| » Lost to Blue Jays (73-56), 2-1 | Hubert H. Humphrey Metrodome (38-26) | 68-61 | |
| » W: Dave Stieb (13-5) L: Ken Schrom (4-7) | First | -- |
| Monday, August 27 |
| » Lost to Blue Jays (74-56), 5-2 | Hubert H. Humphrey Metrodome (38-27) | 68-62 | Lost 2 |
| » W: Dennis Lamp (6-7) L: Mike Smithson (13-10) S: Jimmy Key (6) | First | -- |
| Tuesday, August 28 |
| » Defeated Red Sox (68-63), 2-1 | Hubert H. Humphrey Metrodome (39-27) | 69-62 | |
| » W: Ron Davis (6-9) L: Bob Stanley (7-10) | First | -- |
| Wednesday, August 29 |
| » Lost to Red Sox (69-63), 4-0 | Hubert H. Humphrey Metrodome (39-28) | 69-63 | |
| » W: Oil Can Boyd (9-9) L: John Butcher (10-8) | First | -- |
| Thursday, August 30 |
| » Lost to Red Sox (70-63), 9-3 | Hubert H. Humphrey Metrodome (39-29) | 69-64 | Lost 2 |
| » W: Al Nipper (7-5) L: Ed Hodge (4-3) | First | -- |
| » Major-league debuts: Curt Wardle (Twins) |
| Friday, August 31 |
| » Lost to Blue Jays (77-57), 7-0 | Exhibition Stadium (0-4) | 69-65 | Lost 3 |
| » W: Dave Stieb (14-5) L: Bobby Castillo (2-1) | First | -- |
| Saturday, September 1 |
| » Lost to Blue Jays (78-57), 12-4 | Exhibition Stadium (0-5) | 69-66 | Lost 4 |
| » W: Dennis Lamp (7-7) L: Mike Smithson (13-11) S: Roy Lee Jackson (9) | First | -- |
| Sunday, September 2 |
| » Lost to Blue Jays (79-57), 6-0 | Exhibition Stadium (0-6) | 69-67 | Lost 5 |
| » W: Doyle Alexander (13-5) L: Frank Viola (14-12) | First | -- |
| Monday, September 3 |
| » Defeated Royals (68-69), 4-1 | Royals Stadium (4-0) | 70-67 | |
| » W: John Butcher (11-8) L: Bud Black (14-11) S: Ron Davis (26) | First | -- |
| Tuesday, September 4 |
| » Lost to Royals (69-69), 4-1 | Royals Stadium (4-1) | 70-68 | |
| » W: Mark Gubicza (10-11) L: Ken Schrom (4-8) S: Dan Quisenberry (37) | First | -- |
| Wednesday, September 5 |
| » Lost to Royals (70-69), 4-1 | Royals Stadium (4-2) | 70-69 | Lost 2 |
| » W: Charlie Leibrandt (9-6) L: Mike Smithson (13-12) S: Dan Quisenberry (38) | First | -- |
| Friday, September 7 |
| » Defeated Rangers (61-78), 7-3 | Hubert H. Humphrey Metrodome (40-29) | 71-69 | |
| » W: Frank Viola (15-12) L: Mike Mason (8-12) S: Rick Lysander (4) | First | -- |
| » Major-league debuts: Dwayne Henry (Rangers) |
| Saturday, September 8 |
| » Defeated Rangers (61-79), 5-4 | Hubert H. Humphrey Metrodome (41-29) | 72-69 | Won 2 |
| » W: John Butcher (12-8) L: Dickie Noles (3-4) | First | -- |
| Sunday, September 9 |
| » Lost to Rangers (62-79), 9-3 | Hubert H. Humphrey Metrodome (41-30) | 72-70 | |
| » W: Charlie Hough (15-12) L: Ken Schrom (4-9) | Second | 1 out |
| Monday, September 10 |
| » Defeated Royals (73-70), 7-3 | Hubert H. Humphrey Metrodome (42-30) | 73-70 | |
| » W: Mike Smithson (14-12) L: Mark Gubicza (10-12) | First | -- |
| Tuesday, September 11 |
| » Defeated Royals (73-71), 5-1 | Hubert H. Humphrey Metrodome (43-30) | 74-70 | Won 2 |
| » W: Frank Viola (16-12) L: Charlie Leibrandt (9-7) | First | -- |
| Wednesday, September 12 |
| » Lost to Royals (74-71), 3-2 | Hubert H. Humphrey Metrodome (43-31) | 74-71 | |
| » W: Bud Black (15-11) L: Rick Lysander (3-3) S: Dan Quisenberry (40) | First | -- |
| Friday, September 14 |
| » Lost to Rangers (65-81), 9-2 | Arlington Stadium (1-3) | 74-72 | Lost 2 |
| » W: Charlie Hough (16-12) L: Albert Williams (3-5) | First | -- |
| » Major-league debuts: Alvaro Espinoza (Twins) |
| Saturday, September 15 |
| » Defeated Rangers (65-82), 1-0 | Arlington Stadium (2-3) | 75-72 | |
| » W: Mike Smithson (15-12) L: Danny Darwin (8-11) | First | -- |
| Sunday, September 16 |
| » Defeated Rangers (65-83), 2-0 | Arlington Stadium (3-3) | 76-72 | Won 2 |
| » W: Frank Viola (17-12) L: Dave Stewart (5-14) S: Ron Davis (27) | First | -- |
| Monday, September 17 |
| » Lost to White Sox (68-81), 7-3 | Hubert H. Humphrey Metrodome (43-32) | 76-73 | |
| » W: La Marr Hoyt (13-16) L: John Butcher (12-9) | Second | 1 out |
| Tuesday, September 18 |
| » Lost to White Sox (69-81), 5-3 | Hubert H. Humphrey Metrodome (43-33) | 76-74 | Lost 2 |
| » W: Gene Nelson (3-5) L: Pete Filson (6-5) | Second | |