| Wednesday, January 18 |
| Former Red Sox Leo Kiely dies in Montclair, NJ at the age of 55. |
| Monday, April 2 |
| » Lost to Angels (1-0), 2-1 | Anaheim Stadium (0-1) | 0-1 | |
| » W: Ken Forsch (1-0) L: Bruce Hurst (0-1) | Second | ½ out |
| Wednesday, April 4 |
| » Defeated Angels (1-1), 2-1 | Anaheim Stadium (1-1) | 1-1 | |
| » W: Mark Clear (1-0) L: Luis Sanchez (0-1) | Second | ½ out |
| Thursday, April 5 |
| » Defeated Angels (1-2), 7-4 | Anaheim Stadium (2-1) | 2-1 | Won 2 |
| » W: Bob Stanley (1-0) L: Curt Kaufman (0-1) | Second | ½ out |
| » Major-league debuts: Ron Romanick (Angels) |
| Friday, April 6 |
| » Lost to Athletics (3-0), 3-1 | Oakland-Alameda County Stadium (0-1) | 2-2 | |
| » W: Lary Sorensen (1-0) L: Oil Can Boyd (0-1) S: Bill Caudill (2) | Third | 1½ out |
| Saturday, April 7 |
| » Defeated Athletics (3-1), 3-0 | Oakland-Alameda County Stadium (1-1) | 3-2 | |
| » W: Bruce Hurst (1-1) L: Mike Warren (0-1) | Fourth | 1½ out |
| Sunday, April 8 |
| » Lost to Athletics (4-1), 14-2 | Oakland-Alameda County Stadium (1-2) | 3-3 | |
| » W: Steve McCatty (1-0) L: Mike Brown (0-1) S: Jeff Bettendorf (1) | Fourth | 2½ out |
| » Major-league debuts: Jeff Bettendorf (Athletics) |
| Tuesday, April 10 |
| » Lost to Mariners (5-1), 5-1 | Kingdome (0-1) | 3-4 | Lost 2 |
| » W: Jim Beattie (1-1) L: Bob Ojeda (0-1) S: Mike Stanton (1) | Fourth | 3½ out |
| Wednesday, April 11 |
| » Lost to Mariners (6-1), 5-4 | Kingdome (0-2) | 3-5 | Lost 3 |
| » W: Matt Young (2-0) L: Dennis Eckersley (0-1) S: Roy Thomas (1) | Fifth | 4 out |
| » Major-league debuts: Alvin Davis (Mariners) |
| Friday, April 13 |
| » Lost to Tigers (8-0), 13-9 | Fenway Park (0-1) | 3-6 | Lost 4 |
| » W: Doug Bair (1-0) L: Bruce Hurst (1-2) | Fourth | 5½ out |
| Tuesday, April 17 |
| » Lost to Rangers (4-7), 8-4 | Fenway Park (0-2) | 3-7 | Lost 5 |
| » W: Frank Tanana (1-1) L: Dennis Eckersley (0-2) | Sixth | 6 out |
| Wednesday, April 18 |
| » Lost to Rangers (5-7), 4-3 | Fenway Park (0-3) | 3-8 | Lost 6 |
| » W: Danny Darwin (1-0) L: Bob Ojeda (0-2) S: Dave Tobik (1) | Sixth | 7 out |
| Thursday, April 19 |
| » Lost to Rangers (6-7), 7-4 | Fenway Park (0-4) | 3-9 | Lost 7 |
| » W: Odell Jones (1-0) L: Oil Can Boyd (0-2) | Sixth | 7 out |
| Friday, April 20 |
| » Defeated Athletics (9-6), 3-1 | Fenway Park (1-4) | 4-9 | |
| » W: Bruce Hurst (2-2) L: Tim Conroy (0-1) S: Bob Stanley (1) | Fifth | 7 out |
| Saturday, April 21 |
| » Lost to Athletics (10-6), 5-2 | Fenway Park (1-5) | 4-10 | |
| » W: Mike Warren (2-2) L: Mike Brown (0-2) S: Tom Burgmeier (1) | Sixth | 8 out |
| Sunday, April 22 |
| » Defeated Athletics (10-7), 12-8 | Fenway Park (2-5) | 5-10 | |
| » W: Dennis Eckersley (1-2) L: Steve McCatty (2-1) S: Bob Stanley (2) | Sixth | 8 out |
| Monday, April 23 |
| » Defeated Angels (10-9), 2-0 | Fenway Park (3-5) | 6-10 | Won 2 |
| » W: Bob Ojeda (1-2) L: Geoff Zahn (2-1) | Fifth | 7½ out |
| Tuesday, April 24 |
| » Lost to Angels (11-9), 8-7 | Fenway Park (3-6) | 6-11 | |
| » W: Luis Sanchez (3-1) L: Bob Stanley (1-1) | Sixth | 9 out |
| Wednesday, April 25 |
| » Defeated Mariners (10-8), 2-1 | Fenway Park (4-6) | 7-11 | |
| » W: Bruce Hurst (3-2) L: Jim Beattie (2-2) | Fifth | 9 out |
| Thursday, April 26 |
| » Lost to Mariners (11-8), 6-5 | Fenway Park (4-7) | 7-12 | |
| » W: Ed Vande Berg (1-0) L: Bob Stanley (1-2) S: Paul Mirabella (1) | Fifth | 10 out |
| Friday, April 27 |
| » Defeated White Sox (6-12), 5-3 | Comiskey Park I (1-0) | 8-12 | |
| » W: Dennis Eckersley (2-2) L: La Marr Hoyt (2-2) | Fifth | 9 out |
| Saturday, April 28 |
| » Defeated White Sox (6-13), 8-7 | Comiskey Park I (2-0) | 9-12 | Won 2 |
| » W: Mark Clear (2-0) L: Ron Reed (0-3) S: Bob Stanley (3) | Fifth | 9 out |
| Sunday, April 29 |
| » Lost to White Sox (7-13), 6-4 | Comiskey Park I (2-1) | 9-13 | |
| » W: Richard Dotson (3-2) L: Al Nipper (0-1) S: Al Jones (1) | Fifth | 10 out |
| Tuesday, May 1 |
| » Lost to Tigers (19-2), 11-2 | Tiger Stadium (0-1) | 9-14 | Lost 2 |
| » W: Milt Wilcox (3-0) L: Bruce Hurst (3-3) | Sixth | 11 out |
| Wednesday, May 2 |
| » Defeated Tigers (19-3), 5-4 | Tiger Stadium (1-1) | 10-14 | |
| » W: Mike Brown (1-2) L: Juan Berenguer (1-1) S: Bob Stanley (4) | Sixth | 10 out |
| Thursday, May 3 |
| » Defeated Tigers (19-4), 1-0 | Tiger Stadium (2-1) | 11-14 | Won 2 |
| » W: Bob Ojeda (2-2) L: Jack Morris (5-1) | Fifth | 9 out |
| Friday, May 4 |
| » Lost to White Sox (11-13), 5-3 | Fenway Park (4-8) | 11-15 | |
| » W: Tom Seaver (1-2) L: Dennis Eckersley (2-3) S: Al Jones (2) | Sixth | 10 out |
| Saturday, May 5 |
| » Lost to White Sox (12-13), 8-5 | Fenway Park (4-9) | 11-16 | Lost 2 |
| » W: Richard Dotson (4-2) L: Oil Can Boyd (0-3) S: Ron Reed (3) | Sixth | 11 out |
| Sunday, May 6 |
| » Defeated White Sox (12-14), 3-1 | Fenway Park (5-9) | 12-16 | |
| » W: Bruce Hurst (4-3) L: Floyd Bannister (2-3) | Sixth | 11 out |
| Tuesday, May 8 |
| » Lost to Rangers (10-19), 4-3 | Arlington Stadium (0-1) | 12-17 | |
| » W: Charlie Hough (2-4) L: Mike Brown (1-3) S: Odell Jones (1) | Sixth | 12½ out |
| Wednesday, May 9 |
| » Defeated Rangers (10-20), 2-0 | Arlington Stadium (1-1) | 13-17 | |
| » W: Bob Ojeda (3-2) L: Mike Mason (1-1) S: Bob Stanley (5) | Fifth | 12½ out |
| Friday, May 11 |
| » Lost to Royals (10-18), 6-4 | Royals Stadium (0-1) | 13-18 | |
| » W: Larry Gura (5-1) L: Dennis Eckersley (2-4) S: Dan Quisenberry (8) | Fifth | 13½ out |
| Saturday, May 12 |
| » Lost to Royals (11-18), 3-0 | Royals Stadium (0-2) | 13-19 | Lost 2 |
| » W: Mark Gubicza (1-3) L: Bruce Hurst (4-4) | Sixth | 13½ out |
| Sunday, May 13 |
| » Lost to Royals (12-18), 5-1 | Royals Stadium (0-3) | 13-20 | Lost 3 |
| » W: Bud Black (4-2) L: Mike Brown (1-4) S: Dan Quisenberry (9) | Seventh | 14 out |
| Monday, May 14 |
| » Defeated Indians (12-17), 6-1 | Cleveland Stadium (1-0) | 14-20 | |
| » W: Bob Ojeda (4-2) L: Rick Behenna (0-3) S: Bob Stanley (6) | Seventh | 14 out |
| Tuesday, May 15 |
| » Lost to Indians (13-17), 7-5 | Cleveland Stadium (1-1) | 14-21 | |
| » W: Tom Waddell (1-1) L: John Henry Johnson (0-1) S: Ernie Camacho (5) | Seventh | 15 out |
| » Major-league debuts: Roger Clemens (Red Sox) |
| Wednesday, May 16 |
| » Defeated Indians (13-18), 5-2 | Cleveland Stadium (2-1) | 15-21 | |
| » W: Dennis Eckersley (3-4) L: Steve Farr (0-1) S: Bob Stanley (7) | Seventh | 15 out |
| » Major-league debuts: Steve Farr (Indians) |
| Thursday, May 17 |
| » Defeated Indians (13-19), 11-10 | Cleveland Stadium (3-1) | 16-21 | Won 2 |
| » W: Steve Crawford (1-0) L: Ernie Camacho (0-3) | Sixth | 14½ out |
| Friday, May 18 |
| » Lost to Twins (20-19), 8-3 | Hubert H. Humphrey Metrodome (0-1) | 16-22 | |
| » W: Mike Smithson (6-3) L: Mike Brown (1-5) | Seventh | 15½ out |
| Saturday, May 19 |
| » Lost to Twins (21-19), 7-0 | Hubert H. Humphrey Metrodome (0-2) | 16-23 | Lost 2 |
| » W: Frank Viola (4-4) L: Bob Ojeda (4-3) | Seventh | 16½ out |
| Sunday, May 20 |
| » Defeated Twins (21-20), 5-4 | Hubert H. Humphrey Metrodome (1-2) | 17-23 | |
| » W: Roger Clemens (1-0) L: John Butcher (2-2) S: Bob Stanley (8) | Sixth | 16½ out |
| Monday, May 21 |
| » Defeated Indians (15-21), 6-3 | Fenway Park (6-9) | 18-23 | Won 2 |
| » W: Dennis Eckersley (4-4) L: Steve Farr (0-2) | Fifth | 16 out |
| Tuesday, May 22 |
| » Defeated Indians (15-22), 7-1 | Fenway Park (7-9) | 19-23 | Won 3 |
| » W: Bruce Hurst (5-4) L: Rick Sutcliffe (3-3) | Fifth | 16 out |
| Wednesday, May 23 |
| » Lost to Indians (16-22), 5-4 | Fenway Park (7-10) | 19-24 | |
| » W: Tom Waddell (2-1) L: Bob Stanley (1-3) S: Ernie Camacho (6) | Fifth | 17 out |
| Friday, May 25 |
| » Lost to Royals (17-23), 8-5 | Fenway Park (7-11) | 19-25 | Lost 2 |
| » W: Bret Saberhagen (2-3) L: Bob Ojeda (4-4) S: Dan Quisenberry (12) | Fifth | 17½ out |
| Saturday, May 26 |
| » Lost to Royals (18-23), 11-7 | Fenway Park (7-12) | 19-26 | Lost 3 |
| » W: Paul Splittorff (1-2) L: Bob Stanley (1-4) | Sixth | 17½ out |
| Sunday, May 27 |
| » Defeated Royals (18-24), 6-0 | Fenway Park (8-12) | 20-26 | |
| » W: Bruce Hurst (6-4) L: Joe Beckwith (2-2) | Fifth | 16½ out |
| Wednesday, May 30 |
| » Defeated Twins (23-25), 2-0 | Fenway Park (9-12) | 21-26 | Won 2 |
| » W: Bob Ojeda (5-4) L: John Butcher (3-3) | Fifth | 16½ out |
| Friday, June 1 |
| » Defeated Brewers (22-25), 3-1 | County Stadium (1-0) | 22-26 | Won 3 |
| » W: Bruce Hurst (7-4) L: Don Sutton (3-4) | Fifth | 16½ out |
| Saturday, June 2 |
| » Defeated Brewers (22-26), 6-3 | County Stadium (2-0) | 23-26 | Won 4 |
| » W: Roger Clemens (2-0) L: Chuck Porter (5-2) S: Bob Stanley (9) | Fourth | 15½ out |
| Sunday, June 3 |
| » Defeated Brewers (22-27), 6-3 | County Stadium (3-0) | 24-26 | Won 5 |
| » W: Mark Clear (3-0) L: Pete Ladd (2-3) | Fourth | 14½ out |
| Monday, June 4 |
| » Lost to Yankees (22-29), 8-3 | Yankee Stadium (0-1) | 24-27 | |
| » W: Ron Guidry (4-4) L: Bob Ojeda (5-5) | Fourth | 15½ out |
| Tuesday, June 5 |
| » Defeated Yankees (22-30), 5-4 | Yankee Stadium (1-1) | 25-27 | |
| » W: Mark Clear (4-0) L: Jay Howell (1-3) S: Bob Stanley (10) | Fourth | 14½ out |
| Wednesday, June 6 |
| » Defeated Yankees (22-31), 5-3 | Yankee Stadium (2-1) | 26-27 | Won 2 |
| » W: Bruce Hurst (8-4) L: Jose Rijo (1-6) | Fourth | 13½ out |
| Thursday, June 7 |
| » Lost to Brewers (24-29), 6-3 | Fenway Park (9-13) | 26-28 | |
| » W: Bob McClure (1-1) L: Roger Clemens (2-1) S: Rollie Fingers (10) | Fourth | 14½ out |
| Friday, June 8 |
| » Defeated Brewers (24-30), 11-3 | Fenway Park (10-13) | 27-28 | |
| » W: Oil Can Boyd (1-3) L: Moose Haas (3-5) | Fourth | 14½ out |
| Saturday, June 9 |
| » Defeated Brewers (24-31), 15-6 | Fenway Park (11-13) | 28-28 | Won 2 |
| » W: Bob Ojeda (6-5) L: Bob Gibson (0-1) S: Bob Stanley (11) | Fourth | 13½ out |
| Sunday, June 10 |
| » Defeated Brewers (24-32), 5-4 | Fenway Park (12-13) | 29-28 | Won 3 |
| » W: Rich Gale (1-0) L: Rick Waits (0-2) | Fourth | 14 out |
| Monday, June 11 |
| » Defeated Yankees (25-32), 9-6 | Fenway Park (13-13) | 30-28 | Won 4 |
| » W: Mark Clear (5-0) L: Jay Howell (1-4) | Fourth | 14 out |
| Tuesday, June 12 |
| » Defeated Yankees (25-33), 9-8 | Fenway Park (14-13) | 31-28 | Won 5 |
| » W: Steve Crawford (2-0) L: Dave Righetti (2-1) S: Bob Stanley (12) | Fourth | 13 out |
| Wednesday, June 13 |
| » Lost to Yankees (26-33), 4-2 | Fenway Park (14-14) | 31-29 | |
| » W: Phil Niekro (9-3) L: Oil Can Boyd (1-4) S: Dave Righetti (8) | Fourth | 13 out |
| Thursday, June 14 |
| » Lost to Yankees (27-33), 12-11 | Fenway Park (14-15) | 31-30 | Lost 2 |
| » W: Ray Fontenot (2-5) L: Bob Stanley (1-5) S: Dave Righetti (9) | Fourth | 13½ out |
| Friday, June 15 |
| » Lost to Blue Jays (39-22), 4-3 | Exhibition Stadium (0-1) | 31-31 | Lost 3 |
| » W: Dennis Lamp (4-2) L: Mark Clear (5-1) | Fourth | 14½ out |
| Saturday, June 16 |
| » Lost to Blue Jays (40-22), 7-0 | Exhibition Stadium (0-2) | 31-32 | Lost 4 |
| » W: Luis Leal (7-1) L: Bruce Hurst (8-5) | Fourth | 15½ out |
| Sunday, June 17 |
| » Lost to Blue Jays (41-22), 5-3 | Exhibition Stadium (0-3) | 31-33 | Lost 5 |
| » W: Jim Clancy (6-6) L: Rich Gale (1-1) S: Roy Lee Jackson (3) | Fourth | 16½ out |
| Tuesday, June 19 |
| » Lost to Orioles (38-29), 9-7 | Fenway Park (14-16) | 31-34 | Lost 6 |
| » W: Bill Swaggerty (2-1) L: Bob Stanley (1-6) S: Tippy Martinez (9) | Fourth | 17 out |
| Wednesday, June 20 |
| » Lost to Orioles (39-29), 4-1 | Fenway Park (14-17) | 31-35 | Lost 7 |
| » W: Mike Boddicker (9-5) L: Oil Can Boyd (1-5) | Fourth | 18 out |
| Thursday, June 21 |
| » Lost to Blue Jays (42-24), 5-2 | Fenway Park (14-18) | 31-36 | Lost 8 |
| » W: Luis Leal (8-1) L: Al Nipper (0-2) | Fourth | 18 out |
| Friday, June 22 |
| » Defeated Blue Jays (42-25), 8-1 | Fenway Park (15-18) | 32-36 | |
| » W: Roger Clemens (3-1) L: Jim Clancy (6-7) | Fourth | 18 out |
| Saturday, June 23 |
| » Lost to Blue Jays (43-25), 9-3 | Fenway Park (15-19) | 32-37 | |
| » W: Jim Gott (3-2) L: Rich Gale (1-2) | Fourth | 19 out |
| Sunday, June 24 |
| » Defeated Blue Jays (43-26), 5-3 | Fenway Park (16-19) | 33-37 | |
| » W: Bob Stanley (2-6) L: Dennis Lamp (4-3) | Fourth | 19 out |
| Monday, June 25 |
| » Defeated Orioles (40-32), 7-4 | Memorial Stadium (1-0) | 34-37 | Won 2 |
| » W: Oil Can Boyd (2-5) L: Storm Davis (6-4) S: Mark Clear (1) | Fourth | 18 out |
| Tuesday, June 26 |
| » Defeated Orioles (40-33), 5-2 | Memorial Stadium (2-0) | 35-37 | Won 3 |
| » W: Al Nipper (1-2) L: Mike Boddicker (9-6) S: Bob Stanley (13) | Fourth | 18 out |
| Wednesday, June 27 |
| » Lost to Orioles (41-33), 3-1 | Memorial Stadium (2-1) | 35-38 | |
| » W: Scott McGregor (9-6) L: Roger Clemens (3-2) S: Sammy Stewart (2) | Fourth | 18 out |
| Thursday, June 28 |
| » Defeated Mariners (35-42), 9-6 | Fenway Park (17-19) | 36-38 | |
| » W: Bob Stanley (3-6) L: Paul Mirabella (1-3) | Fourth | 17½ out |
| Friday, June 29 |
| » Lost to Mariners (36-42), 5-3 | Fenway Park (17-20) | 36-39 | |
| » W: Ed Vande Berg (5-7) L: Bob Ojeda (6-6) S: Salome Barojas (2) | Fourth | 18 out |
| Saturday, June 30 |
| » Lost to Mariners (37-42), 2-1 | Fenway Park (17-21) | 36-40 | Lost 2 |
| » W: Jim Beattie (8-7) L: Oil Can Boyd (2-6) | Fourth | 19 out |
| Sunday, July 1 |
| » Lost to Mariners (38-42), 1-0 | Fenway Park (17-22) | 36-41 | Lost 3 |
| » W: Mark Langston (6-6) L: Al Nipper (1-3) | Fourth | 19 out |
| Monday, July 2 |
| » Lost to Athletics (39-42), 9-6 | Fenway Park (17-23) | 36-42 | Lost 4 |
| » W: Bill Caudill (8-1) L: Mark Clear (5-2) S: Lary Sorensen (1) | Fourth | 19 out |
| Tuesday, July 3 |
| » Defeated Athletics (39-43), 6-5 | Fenway Park (18-23) | 37-42 | |
| » W: Bob Stanley (4-6) L: Lary Sorensen (2-9) | Fourth | 18 out |
| Wednesday, July 4 |
| » Defeated Athletics (39-44), 13-9 | Fenway Park (19-23) | 38-42 | Won 2 |
| » W: Steve Crawford (3-0) L: Gorman Heimueller (0-1) | Fourth | 17 out |
| Thursday, July 5 |
| » Defeated Angels (43-40), 12-7 | Fenway Park (20-23) | 39-42 | Won 3 |
| » W: Oil Can Boyd (3-6) L: Geoff Zahn (9-5) S: Bob Stanley (14) | Fourth | 17 out |
| Friday, July 6 |
| » Defeated Angels (43-41), 8-7 | Fenway Park (21-23) | 40-42 | Won 4 |
| » W: Al Nipper (2-3) L: Jim Slaton (2-3) S: Mark Clear (2) | Fourth | 16 out |
| Sunday, July 8 |
| » Defeated Angels (43-42), 3-2 | Fenway Park (22-23) | 41-42 | Won 5 |
| » W: Bob Stanley (5-6) L: Luis Sanchez (5-2) | Fourth | 16 out |
| » Lost to Angels (44-42), 4-0 | Fenway Park (22-24) | 41-43 | |
| » W: Tommy John (5-7) L: Roger Clemens (3-3) | Fourth | 16 out |
| Thursday, July 12 |
| » Lost to Mariners (41-48), 3-2 | Kingdome (0-3) | 41-44 | Lost 2 |
| » W: Mark Langston (7-7) L: Bob Ojeda (6-7) S: Paul Mirabella (3) | Fourth | 16 out |
| Friday, July 13 |
| » Defeated Mariners (41-49), 9-5 | Kingdome (1-3) | 42-44 | |
| » W: Oil Can Boyd (4-6) L: Mike Moore (4-7) | Fourth | 16 out |
| Saturday, July 14 |
| » Lost to Mariners (42-49), 5-4 | Kingdome (1-4) | 42-45 | |
| » W: Ed Vande Berg (6-8) L: Roger Clemens (3-4) S: Mike Stanton (6) | Fourth | 17 out |
| Sunday, July 15 |
| » Defeated Mariners (42-50), 11-3 | Kingdome (2-4) | 43-45 | |
| » W: Al Nipper (3-3) L: Jim Beattie (9-9) | Fourth | 17 out |
| Monday, July 16 |
| » Defeated Athletics (44-49), 4-1 | Oakland-Alameda County Stadium (2-2) | 44-45 | Won 2 |
| » W: Bruce Hurst (9-5) L: Lary Sorensen (3-10) S: Bob Stanley (15) | Fourth | 17 out |
| Tuesday, July 17 |
| » Defeated Athletics (44-50), 6-1 | Oakland-Alameda County Stadium (3-2) | 45-45 | Won 3 |
| » W: Bob Ojeda (7-7) L: Bill Krueger (6-6) | Fourth | 17 out |
| Wednesday, July 18 |
| » Lost to Athletics (45-50), 7-2 | Oakland-Alameda County Stadium (3-3) | 45-46 | |
| » W: Ray Burris (9-4) L: Oil Can Boyd (4-7) | Fourth | 17 out |
| Friday, July 20 |
| » Defeated Angels (49-45), 4-3 | Anaheim Stadium (3-1) | 46-46 | |
| » W: Bob Stanley (6-6) L: Don Aase (0-1) | Fourth | 17½ out |
| Saturday, July 21 |
| » Defeated Angels (49-46), 16-4 | Anaheim Stadium (4-1) | 47-46 | Won 2 |
| » W: Bruce Hurst (10-5) L: Tommy John (5-8) | Fourth | 17½ out |
| Sunday, July 22 |
| » Defeated Angels (49-47), 3-0 | Anaheim Stadium (5-1) | 48-46 | Won 3 |
| » W: Bob Ojeda (8-7) L: Jim Slaton (3-4) | Fourth | 17½ out |
| Tuesday, July 24 |
| » Defeated White Sox (48-49), 3-2 | Fenway Park (23-24) | 49-46 | Won 4 |
| » W: Oil Can Boyd (5-7) L: Floyd Bannister (7-7) S: Bob Stanley (16) | Fourth | 18 out |
| Wednesday, July 25 |
| » Defeated White Sox (48-50), 3-2 | Fenway Park (24-24) | 50-46 | Won 5 |
| » W: Mark Clear (6-2) L: Jerry Don Gleaton (1-1) | Fourth | 17 out |
| Thursday, July 26 |
| » Defeated White Sox (48-51), 7-0 | Fenway Park (25-24) | 51-46 | Won 6 |
| » W: Roger Clemens (4-4) L: Richard Dotson (11-7) | Fourth | 16½ out |
| Friday, July 27 |
| » Lost to Tigers (69-30), 9-1 | Tiger Stadium (2-2) | 51-47 | |
| » W: Dan Petry (14-4) L: Bruce Hurst (10-6) | Fourth | 16½ out |
| » Defeated Tigers (69-31), 4-0 | Tiger Stadium (3-2) | 52-47 | |
| » W: Bob Ojeda (9-7) L: Glenn Abbott (3-3) | Fourth | 16½ out |
| Saturday, July 28 |
| » Defeated Tigers (69-32), 3-2 | Tiger Stadium (4-2) | 53-47 | Won 2 |
| » W: Bob Stanley (7-6) L: Jack Morris (13-7) S: Mark Clear (3) | Fourth | 15½ out |
| Sunday, July 29 |
| » Lost to Tigers (70-32), 3-0 | Tiger Stadium (4-3) | 53-48 | |
| » W: Milt Wilcox (11-6) L: Oil Can Boyd (5-8) S: Willie Hernandez (21) | Fourth | 16½ out |
| Monday, July 30 |
| » Lost to White Sox (50-53), 7-0 | Comiskey Park I (2-2) | 53-49 | Lost 2 |
| » W: Tom Seaver (10-6) L: Al Nipper (3-4) | Fourth | 17 out |
| Tuesday, July 31 |
| » Defeated White Sox (50-54), 14-4 | Comiskey Park I (3-2) | 54-49 | |
| » W: Roger Clemens (5-4) L: Richard Dotson (11-8) | Fourth | 16½ out |
| Wednesday, August 1 |
| » Lost to White Sox (51-54), 5-3 | Comiskey Park I (3-3) | 54-50 | |
| » W: La Marr Hoyt (9-11) L: Bob Ojeda (9-8) | Fourth | 16½ out |
| Friday, August 3 |
| » Lost to Rangers (46-62), 4-3 | Fenway Park (25-25) | 54-51 | Lost 2 |
| » W: Dave Schmidt (4-4) L: Bob Stanley (7-7) | Fourth | 17 out |
| Former Red Sox Elmer Smith dies in Columbia, KY at the age of 92. |
| Saturday, August 4 |
| » Defeated Rangers (46-63), 5-2 | Fenway Park (26-25) | 55-51 | |
| » W: Oil Can Boyd (6-8) L: Frank Tanana (10-11) | Fourth | 16 out |
| Sunday, August 5 |
| » Defeated Rangers (46-64), 4-2 | Fenway Park (27-25) | 56-51 | Won 2 |
| » W: Al Nipper (4-4) L: Charlie Hough (11-10) S: Mark Clear (4) | Fourth | 14½ out |
| Monday, August 6 |
| » Lost to Tigers (73-38), 9-7 | Fenway Park (27-26) | 56-52 | |
| » W: Aurelio Lopez (8-0) L: Bob Ojeda (9-9) S: Willie Hernandez (23) | Fourth | 14½ out |
| » Defeated Tigers (73-39), 10-2 | Fenway Park (28-26) | 57-52 | |
| » W: Roger Clemens (6-4) L: Carl Willis (0-2) | Fourth | 14½ out |
| Tuesday, August 7 |
| » Defeated Tigers (73-40), 12-7 | Fenway Park (29-26) | 58-52 | Won 2 |
| » W: Bruce Hurst (11-6) L: Jack Morris (14-8) S: Mark Clear (5) | Fourth | 14½ out |
| » Lost to Tigers (74-40), 7-5 | Fenway Park (29-27) | 58-53 | |
| » W: Aurelio Lopez (9-0) L: Rich Gale (1-3) S: Willie Hernandez (24) | Fourth | 14½ out |
| Wednesday, August 8 |
| » Defeated Tigers (74-41), 8-0 | Fenway Park (30-27) | 59-53 | |
| » W: Oil Can Boyd (7-8) L: Glenn Abbott (3-4) | Fourth | 13½ out |
| Thursday, August 9 |
| » Lost to Rangers (49-65), 7-3 | Arlington Stadium (1-2) | 59-54 | |
| » W: Frank Tanana (11-11) L: Al Nipper (4-5) | Fourth | 14 out |
| » Major-league debuts: Charlie Mitchell (Red Sox) |
| Friday, August 10 |
| » Lost to Rangers (50-65), 8-4 | Arlington Stadium (1-3) | 59-55 | Lost 2 |
| » W: Charlie Hough (12-10) L: Bob Ojeda (9-10) | Fourth | 15 out |
| Saturday, August 11 |
| » Defeated Rangers (50-66), 5-4 | Arlington Stadium (2-3) | 60-55 | |
| » W: Roger Clemens (7-4) L: Dave Stewart (4-12) S: Bob Stanley (17) | Fourth | 15 out |
| Sunday, August 12 |
| » Defeated Rangers (50-67), 3-2 | Arlington Stadium (3-3) | 61-55 | Won 2 |
| » W: Mark Clear (7-2) L: Dave Schmidt (5-5) S: John Henry Johnson (1) | Third | 15 out |
| Monday, August 13 |
| » Lost to Royals (57-60), 6-1 | Royals Stadium (0-4) | 61-56 | |
| » W: Bud Black (11-10) L: Oil Can Boyd (7-9) | Fourth | 15½ out |
| Tuesday, August 14 |
| » Defeated Royals (57-61), 8-2 | Royals Stadium (1-4) | 62-56 | |
| » W: Al Nipper (5-5) L: Mark Gubicza (8-9) | Third | 14 out |
| Former Red Sox Lynn McGlothen dies in Dubach, LA at the age of 35. |
| Wednesday, August 15 |
| » Lost to Royals (58-61), 13-8 | Royals Stadium (1-5) | 62-57 | |
| » W: Joe Beckwith (6-3) L: Bob Stanley (7-8) S: Dan Quisenberry (31) | Third | 15 out |
| Thursday, August 16 |
| » Defeated Twins (62-57), 7-5 | Fenway Park (31-27) | 63-57 | |
| » W: Steve Crawford (4-0) L: Ron Davis (4-9) S: Mark Clear (6) | Third | 15 out |
| Friday, August 17 |
| » Lost to Twins (63-57), 6-5 | Fenway Park (31-28) | 63-58 | |
| » W: Frank Viola (14-10) L: Bruce Hurst (11-7) S: Ron Davis (24) | Third | 16 out |
| Saturday, August 18 |
| » Lost to Twins (64-57), 6-4 | Fenway Park (31-29) | 63-59 | Lost 2 |
| » W: Ron Davis (5-9) L: Bob Stanley (7-9) S: Rick Lysander (2) | Fifth | 17½ out |
| » Lost to Twins (65-57), 3-1 | Fenway Park (31-30) | 63-60 | Lost 3 |
| » W: Bobby Castillo (1-0) L: John Henry Johnson (0-2) S: Rick Lysander (3) | Fifth | 17½ out |
| Sunday, August 19 |
| » Defeated Twins (65-58), 5-4 | Fenway Park (32-30) | 64-60 | |
| » W: Steve Crawford (5-0) L: Len Whitehouse (2-2) S: Bob Stanley (18) | Fifth | 16½ out |
| Monday, August 20 |
| » Lost to Royals (61-63), 8-5 | Fenway Park (32-31) | 64-61 | |
| » W: Mark Gubicza (9-9) L: Mike Brown (1-6) S: Dan Quisenberry (33) | Fifth | 17½ out |
| Tuesday, August 21 |
| » Defeated Royals (61-64), 11-1 | Fenway Park (33-31) | 65-61 | |
| » W: Roger Clemens (8-4) L: Charlie Leibrandt (7-6) | Fourth | 17½ out |
| Wednesday, August 22 |
| » Lost to Royals (62-64), 6-2 | Fenway Park (33-32) | 65-62 | |
| » W: Joe Beckwith (7-3) L: Bruce Hurst (11-8) | Fifth | 18½ out |
| Friday, August 24 |
| » Defeated Indians (57-72), 7-6 | Fenway Park (34-32) | 66-62 | |
| » W: Oil Can Boyd (8-9) L: Steve Comer (3-8) S: Mark Clear (7) | Fifth | 17½ out |
| Saturday, August 25 |
| » Defeated Indians (57-73), 11-6 | Fenway Park (35-32) | 67-62 | Won 2 |
| » W: Al Nipper (6-5) L: Steve Farr (3-10) S: Steve Crawford (1) | Fifth | 17½ out |
| Former Red Sox Waite Hoyt dies in Cincinnati, OH at the age of 85. |
| Sunday, August 26 |
| » Defeated Indians (57-74), 4-2 | Fenway Park (36-32) | 68-62 | Won 3 |
| » W: Roger Clemens (9-4) L: Roy Smith (5-5) | Fifth | 17½ out |
| Tuesday, August 28 |
| » Lost to Twins (69-62), 2-1 | Hubert H. Humphrey Metrodome (1-3) | 68-63 | |
| » W: Ron Davis (6-9) L: Bob Stanley (7-10) | Fifth | 18½ out |
| Wednesday, August 29 |
| » Defeated Twins (69-63), 4-0 | Hubert H. Humphrey Metrodome (2-3) | 69-63 | |
| » W: Oil Can Boyd (9-9) L: John Butcher (10-8) | Fourth | 17½ out |
| Thursday, August 30 |
| » Defeated Twins (69-64), 9-3 | Hubert H. Humphrey Metrodome (3-3) | 70-63 | Won 2 |
| » W: Al Nipper (7-5) L: Ed Hodge (4-3) | Fourth | 16½ out |
| » Major-league debuts: Curt Wardle (Twins) |
| Friday, August 31 |
| » Defeated Indians (60-76), 8-7 | Cleveland Stadium (4-1) | 71-63 | Won 3 |
| » W: Bob Stanley (8-10) L: Ernie Camacho (4-9) | Fifth | 15½ out |
| Saturday, September 1 |
| » Defeated Indians (60-77), 4-1 | Cleveland Stadium (5-1) | 72-63 | Won 4 |
| » W: Bob Ojeda (10-10) L: Bert Blyleven (15-6) | Fourth | 14½ out |
| Sunday, September 2 |
| » Lost to Indians (61-77), 8-3 | Cleveland Stadium (5-2) | 72-64 | |
| » W: Tom Waddell (5-4) L: Mark Clear (7-3) | Fifth | 15½ out |
| Monday, September 3 |
| » Defeated Brewers (56-81), 8-5 | County Stadium (4-0) | 73-64 | |
| » W: Oil Can Boyd (10-9) L: Jaime Cocanower (8-15) S: Bob Stanley (19) | Fifth | 14½ out |
| Tuesday, September 4 |
| » Defeated Brewers (56-82), 3-1 | County Stadium (5-0) | 74-64 | Won 2 |
| » W: Al Nipper (8-5) L: Don Sutton (12-11) | Fourth | 13½ out |
| Wednesday, September 5 |
| » Lost to Brewers (57-82), 7-5 | County Stadium (5-1) | 74-65 | |
| » W: Moose Haas (8-10) L: Mike Brown (1-7) S: Ray Searage (2) | Fifth | 14½ out |
| Friday, September 7 |
| » Lost to Yankees (75-64), 4-2 | Fenway Park (36-33) | 74-66 | Lost 2 |
| » W: Jay Howell (8-4) L: Bob Ojeda (10-11) S: Dave Righetti (25) | Fourth | 15½ out |
| Former Red Sox Joe Cronin dies in Osterville, MA at the age of 78. |
| Saturday, September 8 |
| » Lost to Yankees (76-64), 12-6 | Fenway Park (36-34) | 74-67 | Lost 3 |
| » W: Joe Cowley (7-1) L: Bruce Hurst (11-9) S: Dave Righetti (26) | Fourth | 16½ out |
| Sunday, September 9 |
| » Defeated Yankees (76-65), 10-1 | Fenway Park (37-34) | 75-67 | |
| » W: Al Nipper (9-5) L: Marty Bystrom (6-6) | Fifth | 16½ out |
| » Major-league debuts: Scott Bradley and Rex Hudler (Yankees) |
| Monday, September 10 |
| » Lost to Brewers (59-84), 7-4 | Fenway Park (37-35) | 75-68 | |
| » W: Don Sutton (13-11) L: Mike Brown (1-8) S: Ray Searage (4) | Fifth | 16½ out |
| Former Red Sox Johnny Marcum dies in Louisville, KY at the age of 76. |
| Tuesday, September 11 |
| » Lost to Brewers (60-84), 14-6 | Fenway Park (37-36) | 75-69 | Lost 2 |
| » W: Moose Haas (9-10) L: Oil Can Boyd (10-10) | Fifth | 17½ out |
| Wednesday, September 12 |
| » Defeated Brewers (60-85), 5-4 | Fenway Park (38-36) | 76-69 | |
| » W: Bob Ojeda (11-11) L: Bob McClure (4-7) S: Bob Stanley (20) | Fifth | 16½ out |
| Friday, September 14 |
| » Lost to Yankees (79-67), 7-1 | Yankee Stadium (2-2) | 76-70 | |
| » W: Joe Cowley (8-1) L: Bruce Hurst (11-10) | Fifth | 16½ out |
| Saturday, September 15 |
| » Defeated Yankees (79-68), 4-3 | Yankee Stadium (3-2) | 77-70 | |
| » W: Al Nipper (10-5) L: John Montefusco (3-3) S: Bob Stanley (21) | Fifth | 16½ out |
| Sunday, September 16 |
| » Defeated Yankees (79-69), 5-3 | Yankee Stadium (4-2) | 78-70 | Won 2 |
| » W: Oil Can Boyd (11-10) L: Dennis Rasmussen (8-6) | Fifth | 16½ out |
| Monday, September 17 |
| » Lost to Blue Jays (84-66), 5-4 | Exhibition Stadium (0-4) | 78-71 | |
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