| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Tuesday, April 3 |
| » Lost to Indians (1-0), 9-1 | Arlington Stadium (0-1) | 0-1 | |
| » W: Rick Sutcliffe (1-0) L: Charlie Hough (0-1) | Third | 1 out |
| Thursday, April 5 |
| » Lost to Indians (2-0), 7-3 | Arlington Stadium (0-2) | 0-2 | Lost 2 |
| » W: Neal Heaton (1-0) L: Dave Stewart (0-1) S: Dan Spillner (1) | Sixth | 2 out |
| Friday, April 6 |
| » Defeated Yankees (1-3), 7-6 | Arlington Stadium (1-2) | 1-2 | |
| » W: Dave Tobik (1-0) L: Dale Murray (0-1) | Fifth | 2 out |
| Saturday, April 7 |
| » Defeated Yankees (1-4), 8-5 | Arlington Stadium (2-2) | 2-2 | Won 2 |
| » W: Mike Mason (1-0) L: Ray Fontenot (0-1) | Second | 1 out |
| Sunday, April 8 |
| » Lost to Yankees (2-4), 4-3 | Arlington Stadium (2-3) | 2-3 | |
| » W: Dale Murray (1-1) L: Dave Tobik (1-1) | Third | 2 out |
| Tuesday, April 10 |
| » Lost to Tigers (6-0), 5-1 | Tiger Stadium (0-1) | 2-4 | Lost 2 |
| » W: Dan Petry (2-0) L: Dave Stewart (0-2) | Fifth | 3 out |
| Thursday, April 12 |
| » Lost to Tigers (7-0), 9-4 | Tiger Stadium (0-2) | 2-5 | Lost 3 |
| » W: Jack Morris (3-0) L: Frank Tanana (0-1) | Sixth | 4 out |
| Friday, April 13 |
| » Lost to Blue Jays (5-3), 3-2 | Arlington Stadium (2-4) | 2-6 | Lost 4 |
| » W: Dennis Lamp (1-2) L: Dave Tobik (1-2) S: Jimmy Key (1) | Sixth | 4 out |
| Saturday, April 14 |
| » Defeated Blue Jays (5-4), 6-2 | Arlington Stadium (3-4) | 3-6 | |
| » W: Charlie Hough (1-1) L: Jim Clancy (0-1) | Sixth | 3½ out |
| Sunday, April 15 |
| » Lost to Blue Jays (6-4), 2-1 | Arlington Stadium (3-5) | 3-7 | |
| » W: Dennis Lamp (2-2) L: Dave Stewart (0-3) | Seventh | 4 out |
| Tuesday, April 17 |
| » Defeated Red Sox (3-7), 8-4 | Fenway Park (1-0) | 4-7 | |
| » W: Frank Tanana (1-1) L: Dennis Eckersley (0-2) | Sixth | 4 out |
| Wednesday, April 18 |
| » Defeated Red Sox (3-8), 4-3 | Fenway Park (2-0) | 5-7 | Won 2 |
| » W: Danny Darwin (1-0) L: Bob Ojeda (0-2) S: Dave Tobik (1) | Seventh | 3 out |
| Thursday, April 19 |
| » Defeated Red Sox (3-9), 7-4 | Fenway Park (3-0) | 6-7 | Won 3 |
| » W: Odell Jones (1-0) L: Oil Can Boyd (0-2) | Seventh | 2½ out |
| Friday, April 20 |
| » Lost to Yankees (6-6), 4-1 | Yankee Stadium (0-1) | 6-8 | |
| » W: Ron Guidry (1-1) L: Dave Stewart (0-4) | Seventh | 3 out |
| Saturday, April 21 |
| » Defeated Yankees (6-7), 1-0 | Yankee Stadium (1-1) | 7-8 | |
| » W: Frank Tanana (2-1) L: Ray Fontenot (0-3) S: Dave Tobik (2) | Fifth | 2½ out |
| Sunday, April 22 |
| » Defeated Yankees (6-8), 4-0 | Yankee Stadium (2-1) | 8-8 | Won 2 |
| » W: Danny Darwin (2-0) L: Jose Rijo (0-1) | Fifth | 1½ out |
| Monday, April 23 |
| » Lost to Indians (7-6), 3-1 | Cleveland Stadium (0-1) | 8-9 | |
| » W: Rick Sutcliffe (3-1) L: Charlie Hough (1-2) S: Ernie Camacho (3) | Sixth | 2 out |
| Wednesday, April 25 |
| » Lost to Tigers (15-1), 9-4 | Arlington Stadium (3-6) | 8-10 | Lost 2 |
| » W: Milt Wilcox (2-0) L: Dave Stewart (0-5) S: Willie Hernandez (2) | Sixth | 2½ out |
| Thursday, April 26 |
| » Lost to Tigers (16-1), 7-5 | Arlington Stadium (3-7) | 8-11 | Lost 3 |
| » W: Doug Bair (2-0) L: Frank Tanana (2-2) S: Aurelio Lopez (2) | Sixth | 3 out |
| Friday, April 27 |
| » Lost to Orioles (7-13), 4-3 | Memorial Stadium (0-1) | 8-12 | Lost 4 |
| » W: Sammy Stewart (3-0) L: Dave Tobik (1-3) | Sixth | 3½ out |
| Saturday, April 28 |
| » Lost to Orioles (8-13), 6-1 | Memorial Stadium (0-2) | 8-13 | Lost 5 |
| » W: Scott McGregor (3-3) L: Charlie Hough (1-3) | Sixth | 4½ out |
| Sunday, April 29 |
| » Lost to Orioles (9-13), 3-2 | Memorial Stadium (0-3) | 8-14 | Lost 6 |
| » W: Storm Davis (1-0) L: Dave Stewart (0-6) S: Tippy Martinez (2) | Sixth | 5 out |
| Tuesday, May 1 |
| » Lost to Blue Jays (14-9), 10-4 | Exhibition Stadium (0-1) | 8-15 | Lost 7 |
| » W: Luis Leal (4-0) L: Frank Tanana (2-3) S: Dennis Lamp (4) | Seventh | 5½ out |
| » Defeated Blue Jays (14-10), 4-1 | Exhibition Stadium (1-1) | 9-15 | |
| » W: Danny Darwin (3-0) L: Doyle Alexander (1-1) | Seventh | 5½ out |
| Wednesday, May 2 |
| » Lost to Blue Jays (15-10), 7-6 | Exhibition Stadium (1-2) | 9-16 | |
| » W: Jim Clancy (2-2) L: Charlie Hough (1-4) S: Dennis Lamp (5) | Seventh | 5½ out |
| Friday, May 4 |
| » Lost to Orioles (12-14), 2-0 | Arlington Stadium (3-8) | 9-17 | Lost 2 |
| » W: Storm Davis (2-0) L: Dave Schmidt (0-1) | Seventh | 6½ out |
| Saturday, May 5 |
| » Lost to Orioles (13-14), 7-5 | Arlington Stadium (3-9) | 9-18 | Lost 3 |
| » W: Dennis Martinez (1-0) L: Ricky Wright (0-1) S: Tippy Martinez (4) | Seventh | 7½ out |
| Sunday, May 6 |
| » Lost to Orioles (14-14), 6-1 | Arlington Stadium (3-10) | 9-19 | Lost 4 |
| » W: Mike Boddicker (2-3) L: Frank Tanana (2-4) | Sixth | 7½ out |
| Tuesday, May 8 |
| » Defeated Red Sox (12-17), 4-3 | Arlington Stadium (4-10) | 10-19 | |
| » W: Charlie Hough (2-4) L: Mike Brown (1-3) S: Odell Jones (1) | Seventh | 6 out |
| Wednesday, May 9 |
| » Lost to Red Sox (13-17), 2-0 | Arlington Stadium (4-11) | 10-20 | |
| » W: Bob Ojeda (3-2) L: Mike Mason (1-1) S: Bob Stanley (5) | Seventh | 6½ out |
| Thursday, May 10 |
| » Lost to White Sox (15-15), 8-6 | Comiskey Park I (0-1) | 10-21 | Lost 2 |
| » W: Salome Barojas (2-0) L: Odell Jones (1-1) | Seventh | 7 out |
| Friday, May 11 |
| » Defeated White Sox (15-16), 6-1 | Comiskey Park I (1-1) | 11-21 | |
| » W: Frank Tanana (3-4) L: Floyd Bannister (2-4) | Sixth | 6 out |
| Saturday, May 12 |
| » Defeated White Sox (15-17), 6-4 | Comiskey Park I (2-1) | 12-21 | Won 2 |
| » W: Dave Stewart (1-6) L: La Marr Hoyt (3-4) S: Dave Tobik (3) | Sixth | 6 out |
| Sunday, May 13 |
| » Lost to White Sox (16-17), 8-1 | Comiskey Park I (2-2) | 12-22 | |
| » W: Britt Burns (2-1) L: Charlie Hough (2-5) | Fifth | 6 out |
| » Major-league debuts: Daryl Boston (White Sox) |
| Tuesday, May 15 |
| » Lost to Brewers (16-16), 3-2 | County Stadium (0-1) | 12-23 | Lost 2 |
| » W: Don Sutton (3-2) L: Mike Mason (1-2) S: Rollie Fingers (7) | Sixth | 6½ out |
| Wednesday, May 16 |
| » Lost to Brewers (17-16), 5-1 | County Stadium (0-2) | 12-24 | Lost 3 |
| » W: Chuck Porter (3-1) L: Danny Darwin (3-1) | Sixth | 6½ out |
| Thursday, May 17 |
| » Defeated Brewers (17-17), 4-1 | County Stadium (1-2) | 13-24 | |
| » W: Frank Tanana (4-4) L: Moose Haas (2-3) | Sixth | 6 out |
| Friday, May 18 |
| » Defeated Royals (13-21), 2-1 | Royals Stadium (1-0) | 14-24 | Won 2 |
| » W: Dave Stewart (2-6) L: Bud Black (4-3) S: Dave Schmidt (1) | Sixth | 6 out |
| Saturday, May 19 |
| » Lost to Royals (14-21), 6-2 | Royals Stadium (1-1) | 14-25 | |
| » W: Mark Gubicza (2-3) L: Charlie Hough (2-6) | Seventh | 7 out |
| Sunday, May 20 |
| » Defeated Royals (14-22), 3-2 | Royals Stadium (2-1) | 15-25 | |
| » W: Mike Mason (2-2) L: Bret Saberhagen (1-3) | Seventh | 7 out |
| Tuesday, May 22 |
| » Lost to Brewers (19-19), 7-1 | Arlington Stadium (4-12) | 15-26 | |
| » W: Chuck Porter (4-1) L: Danny Darwin (3-2) S: Rick Waits (1) | Sixth | 7 out |
| Wednesday, May 23 |
| » Defeated Brewers (19-20), 6-1 | Arlington Stadium (5-12) | 16-26 | |
| » W: Frank Tanana (5-4) L: Moose Haas (2-4) | Sixth | 6 out |
| Thursday, May 24 |
| » Defeated Brewers (19-21), 4-3 | Arlington Stadium (6-12) | 17-26 | Won 2 |
| » W: Dave Stewart (3-6) L: Mike Caldwell (4-4) S: Dave Schmidt (2) | Sixth | 5 out |
| Friday, May 25 |
| » Defeated White Sox (20-24), 11-0 | Arlington Stadium (7-12) | 18-26 | Won 3 |
| » W: Charlie Hough (3-6) L: Tom Seaver (4-4) | Sixth | 5 out |
| Saturday, May 26 |
| » Lost to White Sox (21-24), 5-1 | Arlington Stadium (7-13) | 18-27 | |
| » W: Richard Dotson (7-2) L: Mike Mason (2-3) | Seventh | 5 out |
| Sunday, May 27 |
| » Defeated White Sox (21-25), 11-3 | Arlington Stadium (8-13) | 19-27 | |
| » W: Danny Darwin (4-2) L: Floyd Bannister (3-5) | Sixth | 4 out |
| Monday, May 28 |
| » Lost to Royals (19-24), 6-1 | Arlington Stadium (8-14) | 19-28 | |
| » W: Larry Gura (6-2) L: Frank Tanana (5-5) | Seventh | 5 out |
| Tuesday, May 29 |
| » Lost to Royals (20-24), 7-5 | Arlington Stadium (8-15) | 19-29 | Lost 2 |
| » W: Dan Quisenberry (2-2) L: Dave Schmidt (0-2) | Sixth | 6 out |
| Wednesday, May 30 |
| » Defeated Royals (20-25), 7-3 | Arlington Stadium (9-15) | 20-29 | |
| » W: Charlie Hough (4-6) L: Bret Saberhagen (2-4) | Sixth | 5 out |
| Friday, June 1 |
| » Lost to Mariners (24-27), 5-3 | Arlington Stadium (9-16) | 20-30 | |
| » W: Dave Beard (3-1) L: Dave Tobik (1-4) | Seventh | 6 out |
| Saturday, June 2 |
| » Lost to Mariners (25-27), 10-7 | Arlington Stadium (9-17) | 20-31 | Lost 2 |
| » W: Bob Stoddard (1-2) L: Dave Schmidt (0-3) S: Mike Stanton (2) | Seventh | 7 out |
| Sunday, June 3 |
| » Lost to Mariners (26-27), 10-4 | Arlington Stadium (9-18) | 20-32 | Lost 3 |
| » W: Jim Beattie (4-6) L: Frank Tanana (5-6) S: Dave Beard (5) | Seventh | 8 out |
| Monday, June 4 |
| » Lost to Twins (25-28), 6-2 | Hubert H. Humphrey Metrodome (0-1) | 20-33 | Lost 4 |
| » W: John Butcher (4-3) L: Dave Stewart (3-7) S: Ron Davis (10) | Seventh | 8 out |
| Tuesday, June 5 |
| » Defeated Twins (25-29), 2-1 | Hubert H. Humphrey Metrodome (1-1) | 21-33 | |
| » W: Charlie Hough (5-6) L: Ed Hodge (2-2) | Seventh | 8 out |
| Wednesday, June 6 |
| » Lost to Twins (26-29), 2-1 | Hubert H. Humphrey Metrodome (1-2) | 21-34 | |
| » W: Mike Smithson (7-6) L: Mike Mason (2-4) | Seventh | 8 out |
| Thursday, June 7 |
| » Lost to Twins (27-29), 5-4 | Hubert H. Humphrey Metrodome (1-3) | 21-35 | Lost 2 |
| » W: Ron Davis (3-4) L: Danny Darwin (4-3) | Seventh | 8 out |
| Friday, June 8 |
| » Defeated Athletics (26-31), 8-4 | Arlington Stadium (10-18) | 22-35 | |
| » W: Frank Tanana (6-6) L: Ray Burris (5-3) | Seventh | 7½ out |
| Saturday, June 9 |
| » Defeated Athletics (26-32), 4-3 | Arlington Stadium (11-18) | 23-35 | Won 2 |
| » W: Dave Schmidt (1-3) L: Keith Atherton (3-3) | Seventh | 7½ out |
| Sunday, June 10 |
| » Defeated Athletics (26-33), 3-1 | Arlington Stadium (12-18) | 24-35 | Won 3 |
| » W: Charlie Hough (6-6) L: Bill Krueger (4-2) | Seventh | 7½ out |
| Monday, June 11 |
| » Defeated Athletics (26-34), 6-3 | Arlington Stadium (13-18) | 25-35 | Won 4 |
| » W: Mike Mason (3-4) L: Steve McCatty (3-5) S: Dave Tobik (4) | Seventh | 7 out |
| Tuesday, June 12 |
| » Defeated Twins (28-32), 6-2 | Arlington Stadium (14-18) | 26-35 | Won 5 |
| » W: Danny Darwin (5-3) L: Mike Smithson (7-7) | Sixth | 7 out |
| Wednesday, June 13 |
| » Defeated Twins (28-33), 3-0 | Arlington Stadium (15-18) | 27-35 | Won 6 |
| » W: Frank Tanana (7-6) L: Ken Schrom (0-1) | Sixth | 6 out |
| Thursday, June 14 |
| » Lost to Twins (29-33), 3-2 | Arlington Stadium (15-19) | 27-36 | |
| » W: Frank Viola (5-7) L: Dave Stewart (3-8) S: Ron Davis (11) | Seventh | 7 out |
| Friday, June 15 |
| » Lost to Mariners (31-34), 4-3 | Kingdome (0-1) | 27-37 | Lost 2 |
| » W: Edwin Nunez (1-0) L: Joey McLaughlin (0-1) | Seventh | 8 out |
| Saturday, June 16 |
| » Defeated Mariners (31-35), 5-1 | Kingdome (1-1) | 28-37 | |
| » W: Mike Mason (4-4) L: Ed Vande Berg (4-6) | Seventh | 8 out |
| Sunday, June 17 |
| » Lost to Mariners (32-35), 5-2 | Kingdome (1-2) | 28-38 | |
| » W: Mike Stanton (3-1) L: Odell Jones (1-2) | Seventh | 8 out |
| Monday, June 18 |
| » Defeated Angels (36-31), 6-2 | Anaheim Stadium (1-0) | 29-38 | |
| » W: Frank Tanana (8-6) L: Tommy John (3-6) | Sixth | 7 out |
| Tuesday, June 19 |
| » Defeated Angels (36-32), 4-2 | Anaheim Stadium (2-0) | 30-38 | Won 2 |
| » W: Dave Stewart (4-8) L: Ron Romanick (8-6) S: Odell Jones (2) | Sixth | 6 out |
| Wednesday, June 20 |
| » Defeated Angels (36-33), 3-2 | Anaheim Stadium (3-0) | 31-38 | Won 3 |
| » W: Charlie Hough (7-6) L: Geoff Zahn (8-4) | Fifth | 5 out |
| Friday, June 22 |
| » Defeated Athletics (32-38), 4-0 | Oakland-Alameda County Stadium (1-0) | 32-38 | Won 4 |
| » W: Mike Mason (5-4) L: Steve McCatty (4-6) S: Dave Tobik (5) | Fifth | 5 out |
| Saturday, June 23 |
| » Lost to Athletics (33-38), 5-1 | Oakland-Alameda County Stadium (1-1) | 32-39 | |
| » W: Tim Conroy (1-3) L: Danny Darwin (5-4) | Sixth | 5 out |
| Sunday, June 24 |
| » Lost to Athletics (34-38), 4-2 | Oakland-Alameda County Stadium (1-2) | 32-40 | Lost 2 |
| » W: Bill Caudill (7-1) L: Dave Tobik (1-5) | Seventh | 5 out |
| Monday, June 25 |
| » Defeated Angels (37-36), 5-4 | Arlington Stadium (16-19) | 33-40 | |
| » W: Dave Schmidt (2-3) L: Doug Corbett (2-1) | Seventh | 4 out |
| Tuesday, June 26 |
| » Lost to Angels (38-36), 3-2 | Arlington Stadium (16-20) | 33-41 | |
| » W: Bruce Kison (1-1) L: Odell Jones (1-3) | Sixth | 5 out |
| Wednesday, June 27 |
| » Lost to Angels (39-36), 2-1 | Arlington Stadium (16-21) | 33-42 | Lost 2 |
| » W: Mike Witt (7-7) L: Mike Mason (5-5) S: Luis Sanchez (8) | Sixth | 6 out |
| Thursday, June 28 |
| » Defeated Indians (29-41), 10-6 | Cleveland Stadium (1-1) | 34-42 | |
| » W: Dave Schmidt (3-3) L: Don Schulze (0-1) | Sixth | 6½ out |
| » Lost to Indians (30-41), 7-2 | Cleveland Stadium (1-2) | 34-43 | |
| » W: Roy Smith (2-0) L: Frank Tanana (8-7) S: Ernie Camacho (10) | Sixth | 6½ out |
| Friday, June 29 |
| » Lost to Indians (31-41), 13-12 | Cleveland Stadium (1-3) | 34-44 | Lost 2 |
| » W: Jamie Easterly (1-0) L: Dave Tobik (1-6) | Seventh | 6½ out |
| Saturday, June 30 |
| » Defeated Indians (31-42), 2-1 | Cleveland Stadium (2-3) | 35-44 | |
| » W: Charlie Hough (8-6) L: Steve Comer (1-3) | Sixth | 6½ out |
| Sunday, July 1 |
| » Lost to Indians (32-42), 13-5 | Cleveland Stadium (2-4) | 35-45 | |
| » W: Don Schulze (1-1) L: Mike Mason (5-6) | Sixth | 7½ out |
| Monday, July 2 |
| » Defeated Yankees (33-43), 7-6 | Arlington Stadium (17-21) | 36-45 | |
| » W: Dickie Noles (3-2) L: Jose Rijo (2-8) S: Dave Schmidt (3) | Seventh | 7½ out |
| Tuesday, July 3 |
| » Lost to Yankees (34-43), 5-4 | Arlington Stadium (17-22) | 36-46 | |
| » W: Marty Bystrom (5-4) L: Frank Tanana (8-8) S: Dave Righetti (10) | Seventh | 7½ out |
| Wednesday, July 4 |
| » Lost to Yankees (35-43), 5-0 | Arlington Stadium (17-23) | 36-47 | Lost 2 |
| » W: Phil Niekro (11-4) L: Dave Stewart (4-9) | Sixth | 7½ out |
| Thursday, July 5 |
| » Lost to Tigers (56-25), 7-4 | Arlington Stadium (17-24) | 36-48 | Lost 3 |
| » W: Aurelio Lopez (7-0) L: Charlie Hough (8-7) S: Willie Hernandez (15) | Sixth | 7½ out |
| Friday, July 6 |
| » Defeated Tigers (56-26), 5-3 | Arlington Stadium (18-24) | 37-48 | |
| » W: Mike Mason (6-6) L: Juan Berenguer (4-7) S: Dave Schmidt (4) | Sixth | 6½ out |
| Saturday, July 7 |
| » Lost to Tigers (57-26), 5-2 | Arlington Stadium (18-25) | 37-49 | |
| » W: Dave Rozema (5-1) L: Danny Darwin (5-5) S: Willie Hernandez (16) | Seventh | 7½ out |
| Sunday, July 8 |
| » Defeated Tigers (57-27), 9-7 | Arlington Stadium (19-25) | 38-49 | |
| » W: Frank Tanana (9-8) L: Doug Bair (4-2) S: Dave Schmidt (5) | Seventh | 7½ out |
| Thursday, July 12 |
| » Defeated Indians (33-50), 7-2 | Arlington Stadium (20-25) | 39-49 | Won 2 |
| » W: Charlie Hough (9-7) L: Neal Heaton (5-9) | Seventh | 6½ out |
| Friday, July 13 |
| » Lost to Indians (34-50), 5-0 | Arlington Stadium (20-26) | 39-50 | |
| » W: Bert Blyleven (8-3) L: Mike Mason (6-7) | Seventh | 6½ out |
| Saturday, July 14 |
| » Lost to Indians (35-50), 5-0 | Arlington Stadium (20-27) | 39-51 | Lost 2 |
| » W: Steve Farr (1-5) L: Dave Stewart (4-10) | Seventh | 7½ out |
| Sunday, July 15 |
| » Lost to Indians (36-50), 5-4 | Arlington Stadium (20-28) | 39-52 | Lost 3 |
| » W: Ernie Camacho (4-7) L: Odell Jones (1-4) S: Jamie Easterly (1) | Seventh | 8½ out |
| Monday, July 16 |
| » Lost to Yankees (42-46), 9-8 | Yankee Stadium (2-2) | 39-53 | Lost 4 |
| » W: Mike Armstrong (1-0) L: Dave Schmidt (3-4) | Seventh | 9½ out |
| Tuesday, July 17 |
| » Defeated Yankees (42-47), 10-4 | Yankee Stadium (3-2) | 40-53 | |
| » W: Charlie Hough (10-7) L: Phil Niekro (12-5) | Sixth | 9½ out |
| Wednesday, July 18 |
| » Lost to Yankees (43-47), 3-1 | Yankee Stadium (3-3) | 40-54 | |
| » W: Ron Guidry (8-7) L: Mike Mason (6-8) S: Jay Howell (4) | Seventh | 9½ out |
| Thursday, July 19 |
| » Lost to Tigers (63-29), 9-2 | Tiger Stadium (0-3) | 40-55 | Lost 2 |
| » W: Milt Wilcox (9-6) L: Dave Stewart (4-11) | Seventh | 10 out |
| Friday, July 20 |
| » Lost to Tigers (64-29), 3-1 | Tiger Stadium (0-4) | 40-56 | Lost 3 |
| » W: Dave Rozema (7-1) L: Frank Tanana (9-9) S: Willie Hernandez (18) | Seventh | 10 out |
| Saturday, July 21 |
| » Lost to Tigers (65-29), 7-6 | Tiger Stadium (0-5) | 40-57 | Lost 4 |
| » W: Sid Monge (3-1) L: Dickie Noles (3-3) S: Willie Hernandez (19) | Seventh | 10 out |
| Sunday, July 22 |
| » Lost to Tigers (66-29), 2-0 | Tiger Stadium (0-6) | 40-58 | Lost 5 |
| » W: Dan Petry (13-4) L: Charlie Hough (10-8) S: Willie Hernandez (20) | Seventh | 10 out |
| Monday, July 23 |
| » Lost to Orioles (54-44), 9-5 | Arlington Stadium (20-29) | 40-59 | Lost 6 |
| » W: Mike Boddicker (11-8) L: Mike Mason (6-9) S: Tippy Martinez (14) | Sixth | 11 out |
| » Major-league debuts: Jeff Kunkel (Rangers) |
| Tuesday, July 24 |
| » Defeated Orioles (54-45), 3-2 | Arlington Stadium (21-29) | 41-59 | |
| » W: Danny Darwin (6-5) L: Mike Flanagan (9-9) | Seventh | 10 out |
| Wednesday, July 25 |
| » Lost to Orioles (55-45), 3-1 | Arlington Stadium (21-30) | 41-60 | |
| » W: Dennis Martinez (4-5) L: Frank Tanana (9-10) S: Sammy Stewart (5) | Seventh | 11 out |
| Friday, July 27 |
| » Defeated Blue Jays (57-43), 4-2 | Exhibition Stadium (2-2) | 42-60 | |
| » W: Charlie Hough (11-8) L: Doyle Alexander (8-5) | Seventh | 10 out |
| Saturday, July 28 |
| » Defeated Blue Jays (57-44), 5-4 | Exhibition Stadium (3-2) | 43-60 | Won 2 |
| » W: Mike Mason (7-9) L: Roy Lee Jackson (6-3) S: Dave Schmidt (6) | Sixth | 9½ out |
| Sunday, July 29 |
| » Lost to Blue Jays (58-44), 6-2 | Exhibition Stadium (3-3) | 43-61 | |
| » W: Dave Stieb (12-4) L: Danny Darwin (6-6) | Seventh | 10½ out |
| Monday, July 30 |
| » Defeated Orioles (57-47), 5-1 | Memorial Stadium (1-3) | 44-61 | |
| » W: Frank Tanana (10-10) L: Mike Flanagan (9-10) | Seventh | 10½ out |
| Tuesday, July 31 |
| » Defeated Orioles (57-48), 7-6 | Memorial Stadium (2-3) | 45-61 | Won 2 |
| » W: Odell Jones (2-4) L: Tippy Martinez (4-7) S: Dave Schmidt (7) | Seventh | 10½ out |
| Wednesday, August 1 |
| » Lost to Orioles (58-48), 7-2 | Memorial Stadium (2-4) | 45-62 | |
| » W: Storm Davis (11-4) L: Charlie Hough (11-9) | Seventh | 10½ out |
| Friday, August 3 |
| » Defeated Red Sox (54-51), 4-3 | Fenway Park (4-0) | 46-62 | |
| » W: Dave Schmidt (4-4) L: Bob Stanley (7-7) | Sixth | 10 out |
| Saturday, August 4 |
| » Lost to Red Sox (55-51), 5-2 | Fenway Park (4-1) | 46-63 | |
| » W: Oil Can Boyd (6-8) L: Frank Tanana (10-11) | Seventh | 10½ out |
| Sunday, August 5 |
| » Lost to Red Sox (56-51), 4-2 | Fenway Park (4-2) | 46-64 | Lost 2 |
| » W: Al Nipper (4-4) L: Charlie Hough (11-10) S: Mark Clear (4) | Seventh | 11 out |
| Monday, August 6 |
| » Defeated Blue Jays (63-46), 5-4 | Arlington Stadium (22-30) | 47-64 | |
| » W: Mike Mason (8-9) L: Roy Lee Jackson (7-4) | Seventh | 11 out |
| Tuesday, August 7 |
| » Defeated Blue Jays (63-47), 7-6 | Arlington Stadium (23-30) | 48-64 | Won 2 |
| » W: Dave Schmidt (5-4) L: Dennis Lamp (4-6) | Seventh | 11 out |
| Wednesday, August 8 |
| » Lost to Blue Jays (64-47), 7-2 | Arlington Stadium (23-31) | 48-65 | |
| » W: Jim Clancy (9-11) L: Danny Darwin (6-7) | Seventh | 11 out |
| Thursday, August 9 |
| » Defeated Red Sox (59-54), 7-3 | Arlington Stadium (24-31) | 49-65 | |
| » W: Frank Tanana (11-11) L: Al Nipper (4-5) | Seventh | 10 out |
| » Major-league debuts: Charlie Mitchell (Red Sox) |
| Friday, August 10 |
| » Defeated Red Sox (59-55), 8-4 | Arlington Stadium (25-31) | 50-65 | Won 2 |
| » W: Charlie Hough (12-10) L: Bob Ojeda (9-10) | Seventh | 10 out |
| Saturday, August 11 |
| » Lost to Red Sox (60-55), 5-4 | Arlington Stadium (25-32) | 50-66 | |
| » W: Roger Clemens (7-4) L: Dave Stewart (4-12) S: Bob Stanley (17) | Seventh | 10 out |
| Sunday, August 12 |
| » Lost to Red Sox (61-55), 3-2 | Arlington Stadium (25-33) | 50-67 | Lost 2 |
| » W: Mark Clear (7-2) L: Dave Schmidt (5-5) S: John Henry Johnson (1) | Seventh | 11 out |
| Monday, August 13 |
| » Lost to White Sox (58-59), 5-3 | Comiskey Park I (2-3) | 50-68 | Lost 3 |
| » W: Floyd Bannister (11-7) L: Danny Darwin (6-8) S: Juan Agosto (6) | Seventh | 12 out |
| Tuesday, August 14 |
| » Defeated White Sox (58-60), 9-3 | Comiskey Park I (3-3) | 51-68 | |
| » W: Frank Tanana (12-11) L: Tom Seaver (11-8) | Seventh | 12 out |
| Wednesday, August 15 |
| » Defeated White Sox (58-61), 6-5 | Comiskey Park I (4-3) | 52-68 | Won 2 |
| » W: Charlie Hough (13-10) L: Richard Dotson (12-10) S: Dave Schmidt (8) | Sixth | 11 out |
| Thursday, August 16 |
| » Lost to Royals (59-61), 6-3 | Arlington Stadium (25-34) | 52-69 | |
| » W: Charlie Leibrandt (7-5) L: Mike Mason (8-10) S: Dan Quisenberry (32) | Seventh | 11 out |
| Friday, August 17 |
| » Defeated Royals (59-62), 8-6 | Arlington Stadium (26-34) | 53-69 | |
| » W: Dave Schmidt (6-5) L: Dan Quisenberry (4-3) | Seventh | 11 out |
| Saturday, August 18 |
| » Lost to Royals (60-62), 5-4 | Arlington Stadium (26-35) | 53-70 | |
| » W: Bud Black (12-10) L: Danny Darwin (6-9) S: Mark Huismann (2) | Seventh | 12½ out |
| Sunday, August 19 |
| » Defeated Royals (60-63), 6-4 | Arlington Stadium (27-35) | 54-70 | |
| » W: Frank Tanana (13-11) L: Larry Gura (11-9) S: Dave Schmidt (9) | Seventh | 11½ out |
| Monday, August 20 |
| » Lost to White Sox (60-63), 7-5 | Arlington Stadium (27-36) | 54-71 | |
| » W: Richard Dotson (13-10) L: Charlie Hough (13-11) S: Ron Reed (9) | Sixth | 12 out |
| Tuesday, August 21 |
| » Defeated White Sox (60-64), 4-3 | Arlington Stadium (28-36) | 55-71 | |
| » W: Tom Henke (1-0) L: Bert Roberge (3-1) | Sixth | 11½ out |
| Wednesday, August 22 |
| » Defeated White Sox (60-65), 3-1 | Arlington Stadium (29-36) | 56-71 | Won 2 |
| » W: Danny Darwin (7-9) L: La Marr Hoyt (10-14) S: Dave Schmidt (10) | Sixth | 12 out |
| Friday, August 24 |
| » Defeated Brewers (53-75), 10-3 | County Stadium (2-2) | 57-71 | Won 3 |
| » W: Frank Tanana (14-11) L: Andy Beene (0-2) | Fifth | 10½ out |
| Saturday, August 25 |
| » Lost to Brewers (54-75), 7-6 | County Stadium (2-3) | 57-72 | |
| » W: Don Sutton (12-10) L: Charlie Hough (13-12) S: Jack Lazorko (1) | Fifth | 11½ out |
| Sunday, August 26 |
| » Lost to Brewers (55-75), 6-3 | County Stadium (2-4) | 57-73 | Lost 2 |
| » W: Moose Haas (7-10) L: Mike Mason (8-11) S: Ray Searage (1) | Sixth | 11½ out |
| Tuesday, August 28 |
| » Defeated Royals (65-66), 6-0 | Royals Stadium (3-1) | 58-73 | |
| » W: Danny Darwin (8-9) L: Frank Wills (1-3) | Sixth | 11 out |
| Wednesday, August 29 |
| » Lost to Royals (66-66), 4-1 | Royals Stadium (3-2) | 58-74 | |
| » W: Bud Black (14-10) L: Frank Tanana (14-12) | Sixth | 11 out |
| Thursday, August 30 |
| » Defeated Royals (66-67), 4-3 | Royals Stadium (4-2) | 59-74 | |
| » W: Charlie Hough (14-12) L: Mark Gubicza (9-11) S: Dave Schmidt (11) | Sixth | 10 out |
| Friday, August 31 |
| » Defeated Brewers (56-79), 7-6 | Arlington Stadium (30-36) | 60-74 | Won 2 |
| » W: Joey McLaughlin (1-1) L: Pete Ladd (4-9) | Sixth | 9 out |
| Saturday, September 1 |
| » Defeated Brewers (56-80), 8-4 | Arlington Stadium (31-36) | 61-74 | Won 3 |
| » W: Dave Stewart (5-12) L: Mike Caldwell (6-13) S: Dave Schmidt (12) | Sixth | 8 out |
| Monday, September 3 |
| » Lost to Mariners (61-77), 7-3 | Arlington Stadium (31-37) | 61-75 | |
| » W: Mark Langston (14-9) L: Frank Tanana (14-13) S: Edwin Nunez (6) | Sixth | 8½ out |
| Tuesday, September 4 |
| » Lost to Mariners (62-77), 6-3 | Arlington Stadium (31-38) | 61-76 | Lost 2 |
| » W: Bob Stoddard (2-3) L: Dave Schmidt (6-6) S: Dave Geisel (1) | Seventh | 8½ out |
| Wednesday, September 5 |
| » Lost to Mariners (63-77), 6-5 | Arlington Stadium (31-39) | 61-77 | Lost 3 |
| » W: Paul Mirabella (2-5) L: Dave Stewart (5-13) S: Dave Geisel (2) | Sixth | 8½ out |
| Friday, September 7 |
| » Lost to Twins (71-69), 7-3 | Hubert H. Humphrey Metrodome (1-4) | 61-78 | Lost 4 |
| » W: Frank Viola (15-12) L: Mike Mason (8-12) S: Rick Lysander (4) | Sixth | 9½ out |
| » Major-league debuts: Dwayne Henry (Rangers) |
| Saturday, September 8 |
| » Lost to Twins (72-69), 5-4 | Hubert H. Humphrey Metrodome (1-5) | 61-79 | Lost 5 |
| » W: John Butcher (12-8) L: Dickie Noles (3-4) | Sixth | 10½ out |
| Sunday, September 9 |
| » Defeated Twins (72-70), 9-3 | Hubert H. Humphrey Metrodome (2-5) | 62-79 | |
| » W: Charlie Hough (15-12) L: Ken Schrom (4-9) | Seventh | 10½ out |
| Monday, September 10 |
| » Lost to Mariners (64-80), 7-3 | Kingdome (1-3) | 62-80 | |
| » W: Jim Beattie (11-15) L: Danny Darwin (8-10) | Sixth | 10½ out |
| Tuesday, September 11 |
| » Lost to Mariners (65-80), 4-3 | Kingdome (1-4) | 62-81 | Lost 2 |
| » W: Karl Best (1-0) L: Dickie Noles (3-5) | Seventh | 11½ out |
| Wednesday, September 12 |
| » Defeated Mariners (65-81), 8-1 | Kingdome (2-4) | 63-81 | |
| » W: Mike Mason (9-12) L: Matt Young (4-8) | Sixth | 10½ out |
| » Major-league debuts: Lee Guetterman (Mariners) |
| Thursday, September 13 |
| » Defeated Mariners (65-82), 9-7 | Kingdome (3-4) | 64-81 | Won 2 |
| » W: Frank Tanana (15-13) L: Mike Moore (5-16) S: Tom Henke (1) | Sixth | 10 out |
| Friday, September 14 |
| » Defeated Twins (74-72), 9-2 | Arlington Stadium (32-39) | 65-81 | Won 3 |
| » W: Charlie Hough (16-12) L: Albert Williams (3-5) | Sixth | 9 out |
| » Major-league debuts: Alvaro Espinoza (Twins) |
| Saturday, September 15 |
| » Lost to Twins (75-72), 1-0 | Arlington Stadium (32-40) | 65-82 | |
| » W: Mike Smithson (15-12) L: Danny Darwin (8-11) | Sixth | 10 out |
| Sunday, September 16 |
| » Lost to Twins (76-72), 2-0 | Arlington Stadium (32-41) | 65-83 | Lost 2 |
| » W: Frank Viola (17-12) L: Dave Stewart (5-14) S: Ron Davis (27) | Sixth | 11 out |
| Monday, September 17 |
| » Lost to Athletics (69-82), 5-3 | Oakland-Alameda County Stadium (1-3) | 65-84 | Lost 3 |
| » W: Bill Krueger (9-10) L: Mike Mason (9-13) S: Bill Caudill (32) | Seventh | 12 out |
| Tuesday, September 18 |
| » Lost to Athletics (70-82), 5-2 | Oakland-Alameda County Stadium (1-4) | 65-85 | Lost 4 |
| » W: Chris Codiroli (4-4) L: Frank Tanana (15-14) S: Bill Caudill (33) | Seventh | 13 out |
| Wednesday, September 19 |
| » Lost to Athletics (71-82), 8-7 | Oakland-Alameda County Stadium (1-5) | 65-86 | Lost 5 |
| » W: Steve McCatty (8-14) L: Tom Henke (1-1) | Seventh | 13 out |
| Friday, September 21 |
| » Lost to Angels (78-74), 5-4 | Anaheim Stadium (3-1) | 65-87 | Lost 6 |
| » W: Curt Kaufman (2-2) L: Ricky Wright (0-2) | Seventh | 13½ out |
| Saturday, September 22 |
| » Defeated Angels (78-75), 9-7 | Anaheim Stadium (4-1) | 66-87 | |
| » W: Joey McLaughlin (2-1) L: Luis Sanchez (9-7) S: Tom Henke (2) | Sixth | 13½ out |
| Sunday, September 23 |
| » Defeated Angels (78-76), 2-1 | Anaheim Stadium (5-1) | 67-87 | Won 2 |
| » W: Dave Stewart (6-14) L: Jim Slaton (7-9) | Sixth | 12½ out |
| Monday, September 24 |
| » Lost to Athletics (73-84) |