| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Tuesday, April 3 |
| » Defeated Pirates (0-1), 5-1 | San Diego/Jack Murphy Stadium (1-0) | 1-0 | |
| » W: Eric Show (1-0) L: Rick Rhoden (0-1) | First | -- |
| Thursday, April 5 |
| » Defeated Pirates (0-2), 8-6 | San Diego/Jack Murphy Stadium (2-0) | 2-0 | Won 2 |
| » W: Luis DeLeon (1-0) L: Rod Scurry (0-1) S: Rich Gossage (1) | First | -- |
| Friday, April 6 |
| » Defeated Cubs (2-1), 3-2 | San Diego/Jack Murphy Stadium (3-0) | 3-0 | Won 3 |
| » W: Sid Monge (1-0) L: Lee Smith (0-1) | First | -- |
| Saturday, April 7 |
| » Defeated Cubs (2-2), 7-6 | San Diego/Jack Murphy Stadium (4-0) | 4-0 | Won 4 |
| » W: Dave Dravecky (1-0) L: Steve Trout (0-1) S: Rich Gossage (2) | First | -- |
| Sunday, April 8 |
| » Lost to Cubs (3-2), 8-5 | San Diego/Jack Murphy Stadium (4-1) | 4-1 | |
| » W: Lee Smith (1-1) L: Mark Thurmond (0-1) | First | -- |
| Tuesday, April 10 |
| » Defeated Cardinals (3-3), 7-3 | San Diego/Jack Murphy Stadium (5-1) | 5-1 | |
| » W: Andy Hawkins (1-0) L: Bob Forsch (0-1) S: Dave Dravecky (1) | First | -- |
| Wednesday, April 11 |
| » Defeated Cardinals (3-4), 7-5 | San Diego/Jack Murphy Stadium (6-1) | 6-1 | Won 2 |
| » W: Tim Lollar (1-0) L: Joaquin Andujar (1-1) | First | -- |
| Thursday, April 12 |
| » Defeated Braves (2-6), 6-1 | San Diego/Jack Murphy Stadium (7-1) | 7-1 | Won 3 |
| » W: Ed Whitson (1-0) L: Pete Falcone (0-2) S: Dave Dravecky (2) | First | -- |
| Friday, April 13 |
| » Defeated Braves (2-7), 5-2 | San Diego/Jack Murphy Stadium (8-1) | 8-1 | Won 4 |
| » W: Eric Show (2-0) L: Len Barker (1-2) S: Rich Gossage (3) | First | -- |
| Saturday, April 14 |
| » Lost to Braves (3-7), 5-1 | San Diego/Jack Murphy Stadium (8-2) | 8-2 | |
| » W: Rick Camp (1-0) L: Mark Thurmond (0-2) S: Jeff Dedmon (1) | First | -- |
| Sunday, April 15 |
| » Defeated Braves (3-8), 6-4 | San Diego/Jack Murphy Stadium (9-2) | 9-2 | |
| » W: Sid Monge (2-0) L: Craig McMurtry (1-2) S: Rich Gossage (4) | First | -- |
| Tuesday, April 17 |
| » Defeated Giants (4-7), 2-1 | Candlestick Park (1-0) | 10-2 | Won 2 |
| » W: Tim Lollar (2-0) L: Mark Davis (0-3) S: Rich Gossage (5) | First | -- |
| Thursday, April 19 |
| » Lost to Dodgers (8-6), 4-0 | Dodger Stadium (0-1) | 10-3 | |
| » W: Alejandro Pena (2-1) L: Ed Whitson (1-1) | First | -- |
| Friday, April 20 |
| » Lost to Dodgers (9-6), 8-2 | Dodger Stadium (0-2) | 10-4 | Lost 2 |
| » W: Fernando Valenzuela (1-2) L: Eric Show (2-1) | First | -- |
| Saturday, April 21 |
| » Defeated Dodgers (9-7), 9-6 | Dodger Stadium (1-2) | 11-4 | |
| » W: Mark Thurmond (1-2) L: Jerry Reuss (1-1) S: Rich Gossage (6) | First | -- |
| Sunday, April 22 |
| » Lost to Dodgers (10-7), 15-7 | Dodger Stadium (1-3) | 11-5 | |
| » W: Rick Honeycutt (3-0) L: Tim Lollar (2-1) | First | -- |
| Monday, April 23 |
| » Defeated Giants (7-9), 8-2 | San Diego/Jack Murphy Stadium (10-2) | 12-5 | |
| » W: Andy Hawkins (2-0) L: Jeff Robinson (2-2) | First | -- |
| Tuesday, April 24 |
| » Defeated Giants (7-10), 6-1 | San Diego/Jack Murphy Stadium (11-2) | 13-5 | Won 2 |
| » W: Ed Whitson (2-1) L: Mike Krukow (1-3) | First | -- |
| Wednesday, April 25 |
| » Defeated Giants (7-11), 3-0 | San Diego/Jack Murphy Stadium (12-2) | 14-5 | Won 3 |
| » W: Eric Show (3-1) L: Bill Laskey (0-2) S: Rich Gossage (7) | First | -- |
| Thursday, April 26 |
| » Lost to Dodgers (14-7), 6-5 | San Diego/Jack Murphy Stadium (12-3) | 14-6 | |
| » W: Carlos Diaz (1-0) L: Dave Dravecky (1-1) S: Tom Niedenfuer (4) | First | -- |
| Friday, April 27 |
| » Lost to Dodgers (15-7), 1-0 | San Diego/Jack Murphy Stadium (12-4) | 14-7 | Lost 2 |
| » W: Rick Honeycutt (4-0) L: Tim Lollar (2-2) | Second | ½ out |
| Saturday, April 28 |
| » Defeated Dodgers (15-8), 5-1 | San Diego/Jack Murphy Stadium (13-4) | 15-7 | |
| » W: Andy Hawkins (3-0) L: Bob Welch (2-3) | First | -- |
| » Major-league debuts: Franklin Stubbs (Dodgers) |
| Sunday, April 29 |
| » Lost to Dodgers (16-8), 6-0 | San Diego/Jack Murphy Stadium (13-5) | 15-8 | |
| » W: Alejandro Pena (4-1) L: Ed Whitson (2-2) | Second | ½ out |
| Tuesday, May 1 |
| » Defeated Braves (9-13), 3-2 | Atlanta-Fulton County Stadium (1-0) | 16-8 | |
| » W: Eric Show (4-1) L: Craig McMurtry (2-3) S: Rich Gossage (8) | Second | 1 out |
| Thursday, May 3 |
| » Lost to Braves (10-13), 6-5 | Atlanta-Fulton County Stadium (1-1) | 16-9 | |
| » W: Steve Bedrosian (2-1) L: Rich Gossage (0-1) S: Terry Forster (2) | Second | 1 out |
| Friday, May 4 |
| » Lost to Cubs (13-10), 7-6 | Wrigley Field (0-1) | 16-10 | Lost 2 |
| » W: Lee Smith (2-2) L: Sid Monge (2-1) | Second | 1½ out |
| Saturday, May 5 |
| » Lost to Cubs (14-10), 6-5 | Wrigley Field (0-2) | 16-11 | Lost 3 |
| » W: Warren Brusstar (1-0) L: Craig Lefferts (0-1) | Second | 1½ out |
| Sunday, May 6 |
| » Defeated Cubs (14-11), 8-5 | Wrigley Field (1-2) | 17-11 | |
| » W: Eric Show (5-1) L: Dick Ruthven (2-3) | Second | 1 out |
| Wednesday, May 9 |
| » Defeated Cardinals (14-17), 3-2 | Busch Stadium II (1-0) | 18-11 | Won 2 |
| » W: Mark Thurmond (2-2) L: John Stuper (0-2) S: Rich Gossage (9) | First | -- |
| Thursday, May 10 |
| » Lost to Cardinals (15-17), 7-0 | Busch Stadium II (1-1) | 18-12 | |
| » W: Joaquin Andujar (5-3) L: Tim Lollar (2-3) | Second | 2 out |
| » Major-league debuts: Tom Nieto (Cardinals) |
| Friday, May 11 |
| » Lost to Phillies (14-16), 6-4 | San Diego/Jack Murphy Stadium (13-6) | 18-13 | Lost 2 |
| » W: Al Holland (1-2) L: Dave Dravecky (1-2) | Second | 2 out |
| Saturday, May 12 |
| » Lost to Phillies (15-16), 3-2 | San Diego/Jack Murphy Stadium (13-7) | 18-14 | Lost 3 |
| » W: Bill Campbell (3-0) L: Andy Hawkins (3-1) S: Al Holland (6) | Third | 2 out |
| Sunday, May 13 |
| » Lost to Phillies (16-16), 8-3 | San Diego/Jack Murphy Stadium (13-8) | 18-15 | Lost 4 |
| » W: John Denny (3-3) L: Ed Whitson (2-3) | Third | 2 out |
| Monday, May 14 |
| » Lost to Expos (17-17), 7-6 | San Diego/Jack Murphy Stadium (13-9) | 18-16 | Lost 5 |
| » W: Jeff Reardon (1-1) L: Dave Dravecky (1-3) | Fourth | 2 out |
| Tuesday, May 15 |
| » Lost to Expos (18-17), 6-4 | San Diego/Jack Murphy Stadium (13-10) | 18-17 | Lost 6 |
| » W: Bryn Smith (5-2) L: Tim Lollar (2-4) S: Dan Schatzeder (1) | Fourth | 2 out |
| Wednesday, May 16 |
| » Lost to Expos (19-17), 3-2 | San Diego/Jack Murphy Stadium (13-11) | 18-18 | Lost 7 |
| » W: Charlie Lea (6-2) L: Eric Show (5-2) S: Jeff Reardon (6) | Fourth | 2 out |
| Thursday, May 17 |
| » Defeated Expos (19-18), 5-4 | San Diego/Jack Murphy Stadium (14-11) | 19-18 | |
| » W: Rich Gossage (1-1) L: Andy McGaffigan (2-2) S: Craig Lefferts (1) | Fourth | 1½ out |
| Friday, May 18 |
| » Defeated Mets (19-15), 5-4 | San Diego/Jack Murphy Stadium (15-11) | 20-18 | Won 2 |
| » W: Ed Whitson (3-3) L: Dwight Gooden (3-3) S: Rich Gossage (10) | Second | 1½ out |
| Saturday, May 19 |
| » Defeated Mets (19-16), 8-3 | San Diego/Jack Murphy Stadium (16-11) | 21-18 | Won 3 |
| » W: Mark Thurmond (3-2) L: Ed Lynch (4-1) S: Dave Dravecky (3) | Second | 1½ out |
| Sunday, May 20 |
| » Lost to Mets (20-16), 4-2 | San Diego/Jack Murphy Stadium (16-12) | 21-19 | |
| » W: Jesse Orosco (4-1) L: Craig Lefferts (0-2) | Third | 1½ out |
| Tuesday, May 22 |
| » Lost to Expos (21-20), 3-2 | Stade Olympique (0-1) | 21-20 | Lost 2 |
| » W: Charlie Lea (7-2) L: Eric Show (5-3) | Third | 1½ out |
| Wednesday, May 23 |
| » Defeated Expos (21-21), 2-1 | Stade Olympique (1-1) | 22-20 | |
| » W: Dave Dravecky (2-3) L: Andy McGaffigan (3-3) | Third | 1½ out |
| Friday, May 25 |
| » Defeated Phillies (24-18), 7-3 | Veteran's Stadium (1-0) | 23-20 | Won 2 |
| » W: Ed Whitson (4-3) L: Charles Hudson (5-3) | First | -- |
| Saturday, May 26 |
| » Lost to Phillies (25-18), 7-2 | Veteran's Stadium (1-1) | 23-21 | |
| » W: Marty Bystrom (2-1) L: Mark Thurmond (3-3) | First | -- |
| Sunday, May 27 |
| » Defeated Phillies (25-19), 4-0 | Veteran's Stadium (2-1) | 24-21 | |
| » W: Tim Lollar (3-4) L: Jerry Koosman (4-6) S: Craig Lefferts (2) | First | -- |
| Monday, May 28 |
| » Defeated Mets (22-20), 5-4 | Shea Stadium (1-0) | 25-21 | Won 2 |
| » W: Eric Show (6-3) L: Brent Gaff (0-1) S: Rich Gossage (11) | First | -- |
| Friday, June 1 |
| » Lost to Giants (17-29), 11-7 | Candlestick Park (1-1) | 25-22 | |
| » W: Frank Williams (2-0) L: Andy Hawkins (3-2) S: Greg Minton (2) | Third | 2½ out |
| Saturday, June 2 |
| » Defeated Giants (17-30), 3-2 | Candlestick Park (2-1) | 26-22 | |
| » W: Rich Gossage (2-1) L: Scott Garrelts (1-1) | Third | 2 out |
| Sunday, June 3 |
| » Defeated Giants (17-31), 7-5 | Candlestick Park (3-1) | 27-22 | Won 2 |
| » W: Tim Lollar (4-4) L: Jeff Cornell (0-1) S: Dave Dravecky (4) | Second | 1½ out |
| » Defeated Giants (17-32), 7-6 | Candlestick Park (4-1) | 28-22 | Won 3 |
| » W: Eric Show (7-3) L: Gary Lavelle (2-2) S: Rich Gossage (12) | Second | 1½ out |
| Monday, June 4 |
| » Defeated Astros (22-30), 3-0 | San Diego/Jack Murphy Stadium (17-12) | 29-22 | Won 4 |
| » W: Ed Whitson (5-3) L: Mike Scott (2-4) S: Dave Dravecky (5) | Second | 1½ out |
| Tuesday, June 5 |
| » Defeated Astros (22-31), 3-0 | San Diego/Jack Murphy Stadium (18-12) | 30-22 | Won 5 |
| » W: Andy Hawkins (4-2) L: Vern Ruhle (0-4) | Second | 1½ out |
| Wednesday, June 6 |
| » Defeated Astros (22-32), 4-3 | San Diego/Jack Murphy Stadium (19-12) | 31-22 | Won 6 |
| » W: Rich Gossage (3-1) L: Dave Smith (0-2) | Second | 1½ out |
| Thursday, June 7 |
| » Lost to Reds (28-29), 12-1 | San Diego/Jack Murphy Stadium (19-13) | 31-23 | |
| » W: Bruce Berenyi (3-6) L: Eric Show (7-4) S: Keefe Cato (1) | Second | 1½ out |
| Friday, June 8 |
| » Defeated Reds (28-30), 6-0 | San Diego/Jack Murphy Stadium (20-13) | 32-23 | |
| » W: Tim Lollar (5-4) L: Joe Price (2-4) | Second | 1½ out |
| Saturday, June 9 |
| » Defeated Reds (28-31), 12-2 | San Diego/Jack Murphy Stadium (21-13) | 33-23 | Won 2 |
| » W: Ed Whitson (6-3) L: Jeff Russell (2-7) S: Craig Lefferts (3) | First | -- |
| Sunday, June 10 |
| » Defeated Reds (28-32), 7-5 | San Diego/Jack Murphy Stadium (22-13) | 34-23 | Won 3 |
| » W: Floyd Chiffer (1-0) L: Tom Hume (3-6) S: Dave Dravecky (6) | First | -- |
| Monday, June 11 |
| » Defeated Braves (34-27), 5-4 | San Diego/Jack Murphy Stadium (23-13) | 35-23 | Won 4 |
| » W: Dave Dravecky (3-3) L: Steve Bedrosian (4-3) | First | -- |
| Tuesday, June 12 |
| » Defeated Braves (34-28), 7-6 | San Diego/Jack Murphy Stadium (24-13) | 36-23 | Won 5 |
| » W: Craig Lefferts (1-2) L: Steve Bedrosian (4-4) | First | -- |
| Thursday, June 14 |
| » Lost to Giants (22-38), 5-2 | San Diego/Jack Murphy Stadium (24-14) | 36-24 | |
| » W: Mark Davis (3-6) L: Tim Lollar (5-5) S: Gary Lavelle (7) | First | -- |
| Friday, June 15 |
| » Defeated Giants (22-39), 3-2 | San Diego/Jack Murphy Stadium (25-14) | 37-24 | |
| » W: Ed Whitson (7-3) L: Jeff Robinson (3-7) S: Rich Gossage (13) | First | -- |
| Saturday, June 16 |
| » Lost to Giants (23-39), 6-3 | San Diego/Jack Murphy Stadium (25-15) | 37-25 | |
| » W: Bill Laskey (3-6) L: Andy Hawkins (4-3) S: Greg Minton (4) | First | -- |
| Sunday, June 17 |
| » Lost to Giants (24-39), 5-3 | San Diego/Jack Murphy Stadium (25-16) | 37-26 | Lost 2 |
| » W: Frank Williams (4-0) L: Craig Lefferts (1-3) | First | -- |
| Tuesday, June 19 |
| » Defeated Astros (30-36), 2-0 | Astrodome (1-0) | 38-26 | |
| » W: Eric Show (8-4) L: Bob Knepper (6-7) | First | -- |
| Wednesday, June 20 |
| » Defeated Astros (30-37), 6-2 | Astrodome (2-0) | 39-26 | Won 2 |
| » W: Tim Lollar (6-5) L: Mike Madden (2-2) S: Dave Dravecky (7) | First | -- |
| Thursday, June 21 |
| » Lost to Astros (31-37), 11-5 | Astrodome (2-1) | 39-27 | |
| » W: Joe Niekro (6-7) L: Ed Whitson (7-4) S: Mike LaCoss (3) | First | -- |
| Friday, June 22 |
| » Lost to Reds (33-38), 8-7 | Riverfront Stadium (0-1) | 39-28 | Lost 2 |
| » W: John Franco (3-0) L: Rich Gossage (3-2) | First | -- |
| Saturday, June 23 |
| » Defeated Reds (33-39), 5-2 | Riverfront Stadium (1-1) | 40-28 | |
| » W: Mark Thurmond (4-3) L: Charlie Puleo (0-1) | First | -- |
| Sunday, June 24 |
| » Defeated Reds (33-40), 8-3 | Riverfront Stadium (2-1) | 41-28 | Won 2 |
| » W: Dave Dravecky (4-3) L: Tom Hume (3-7) | First | -- |
| Monday, June 25 |
| » Defeated Dodgers (39-36), 9-4 | Dodger Stadium (2-3) | 42-28 | Won 3 |
| » W: Tim Lollar (7-5) L: Pat Zachry (4-2) | First | -- |
| » Major-league debuts: Ken Howell (Dodgers) |
| Tuesday, June 26 |
| » Defeated Dodgers (39-37), 5-0 | Dodger Stadium (3-3) | 43-28 | Won 4 |
| » W: Ed Whitson (8-4) L: Bob Welch (6-8) | First | -- |
| Wednesday, June 27 |
| » Lost to Dodgers (40-37), 5-4 | Dodger Stadium (3-4) | 43-29 | |
| » W: Fernando Valenzuela (8-8) L: Dave Dravecky (4-4) S: Tom Niedenfuer (9) | First | -- |
| Thursday, June 28 |
| » Defeated Cardinals (36-40), 7-3 | San Diego/Jack Murphy Stadium (26-16) | 44-29 | |
| » W: Mark Thurmond (5-3) L: Ken Dayley (0-5) | First | -- |
| Friday, June 29 |
| » Lost to Cardinals (37-40), 5-0 | San Diego/Jack Murphy Stadium (26-17) | 44-30 | |
| » W: Ricky Horton (4-1) L: Eric Show (8-5) | First | -- |
| Saturday, June 30 |
| » Lost to Cardinals (38-40), 4-1 | San Diego/Jack Murphy Stadium (26-18) | 44-31 | Lost 2 |
| » W: Joaquin Andujar (13-6) L: Tim Lollar (7-6) S: Bruce Sutter (19) | First | -- |
| Sunday, July 1 |
| » Defeated Cardinals (38-41), 3-1 | San Diego/Jack Murphy Stadium (27-18) | 45-31 | |
| » W: Ed Whitson (9-4) L: Dave LaPoint (6-8) S: Rich Gossage (14) | First | -- |
| Monday, July 2 |
| » Defeated Cubs (43-35), 5-1 | San Diego/Jack Murphy Stadium (28-18) | 46-31 | Won 2 |
| » W: Dave Dravecky (5-4) L: Rick Reuschel (4-4) | First | -- |
| Tuesday, July 3 |
| » Lost to Cubs (44-35), 3-2 | San Diego/Jack Murphy Stadium (28-19) | 46-32 | |
| » W: Steve Trout (9-3) L: Mark Thurmond (5-4) S: Tim Stoddard (5) | First | -- |
| Wednesday, July 4 |
| » Lost to Cubs (45-35), 2-1 | San Diego/Jack Murphy Stadium (28-20) | 46-33 | Lost 2 |
| » W: Rick Sutcliffe (7-6) L: Eric Show (8-6) S: Lee Smith (16) | First | -- |
| Thursday, July 5 |
| » Defeated Pirates (31-50), 2-1 | San Diego/Jack Murphy Stadium (29-20) | 47-33 | |
| » W: Rich Gossage (4-2) L: Rod Scurry (1-5) | First | -- |
| Friday, July 6 |
| » Defeated Pirates (31-51), 7-3 | San Diego/Jack Murphy Stadium (30-20) | 48-33 | Won 2 |
| » W: Ed Whitson (10-4) L: Rick Rhoden (6-7) | First | -- |
| Saturday, July 7 |
| » Defeated Pirates (31-52), 1-0 | San Diego/Jack Murphy Stadium (31-20) | 49-33 | Won 3 |
| » W: Dave Dravecky (6-4) L: Larry McWilliams (4-8) S: Rich Gossage (15) | First | -- |
| Sunday, July 8 |
| » Lost to Pirates (32-52), 4-3 | San Diego/Jack Murphy Stadium (31-21) | 49-34 | |
| » W: John Candelaria (7-6) L: Mark Thurmond (5-5) S: Kent Tekulve (7) | First | -- |
| Thursday, July 12 |
| » Defeated Cardinals (42-45), 4-1 | Busch Stadium II (2-1) | 50-34 | |
| » W: Eric Show (9-6) L: Joaquin Andujar (13-7) S: Craig Lefferts (4) | First | -- |
| Friday, July 13 |
| » Lost to Cardinals (43-45), 7-4 | Busch Stadium II (2-2) | 50-35 | |
| » W: Neil Allen (5-3) L: Luis DeLeon (1-1) | First | -- |
| Saturday, July 14 |
| » Lost to Cardinals (44-45), 7-6 | Busch Stadium II (2-3) | 50-36 | Lost 2 |
| » W: Dave LaPoint (7-8) L: Tim Lollar (7-7) S: Bruce Sutter (22) | First | -- |
| Sunday, July 15 |
| » Defeated Cardinals (44-46), 6-1 | Busch Stadium II (3-3) | 51-36 | |
| » W: Dave Dravecky (7-4) L: Kurt Kepshire (1-1) | First | -- |
| Monday, July 16 |
| » Defeated Cubs (51-38), 4-0 | Wrigley Field (2-2) | 52-36 | Won 2 |
| » W: Mark Thurmond (6-5) L: Dick Ruthven (2-6) | First | -- |
| Tuesday, July 17 |
| » Defeated Cubs (51-39), 6-5 | Wrigley Field (3-2) | 53-36 | Won 3 |
| » W: Eric Show (10-6) L: Steve Trout (9-4) S: Rich Gossage (16) | First | -- |
| Wednesday, July 18 |
| » Lost to Cubs (52-39), 4-1 | Wrigley Field (3-3) | 53-37 | |
| » W: Rick Sutcliffe (10-6) L: Ed Whitson (10-5) | First | -- |
| Thursday, July 19 |
| » Lost to Pirates (40-53), 5-1 | Three Rivers Stadium (0-1) | 53-38 | Lost 2 |
| » W: John Candelaria (9-6) L: Tim Lollar (7-8) | First | -- |
| Friday, July 20 |
| » Lost to Pirates (41-53), 4-3 | Three Rivers Stadium (0-2) | 53-39 | Lost 3 |
| » W: Rick Rhoden (8-7) L: Dave Dravecky (7-5) S: Don Robinson (5) | First | -- |
| » Defeated Pirates (41-54), 3-2 | Three Rivers Stadium (1-2) | 54-39 | |
| » W: Andy Hawkins (5-3) L: John Tudor (5-8) S: Rich Gossage (17) | First | -- |
| Saturday, July 21 |
| » Defeated Pirates (41-55), 6-4 | Three Rivers Stadium (2-2) | 55-39 | Won 2 |
| » W: Mark Thurmond (7-5) L: Bob Walk (1-1) S: Rich Gossage (18) | First | -- |
| Sunday, July 22 |
| » Defeated Pirates (41-56), 5-1 | Three Rivers Stadium (3-2) | 56-39 | Won 3 |
| » W: Ed Whitson (11-5) L: Jose DeLeon (6-6) | First | -- |
| » Lost to Pirates (42-56), 3-2 | Three Rivers Stadium (3-3) | 56-40 | |
| » W: Jim Winn (1-0) L: Rich Gossage (4-3) | First | -- |
| Tuesday, July 24 |
| » Lost to Reds (42-57), 4-2 | San Diego/Jack Murphy Stadium (31-22) | 56-41 | Lost 2 |
| » W: Mario Soto (11-3) L: Tim Lollar (7-9) | First | -- |
| Wednesday, July 25 |
| » Defeated Reds (42-58), 6-5 | San Diego/Jack Murphy Stadium (32-22) | 57-41 | |
| » W: Rich Gossage (5-3) L: Bob Owchinko (3-5) | First | -- |
| Thursday, July 26 |
| » Defeated Reds (42-59), 8-2 | San Diego/Jack Murphy Stadium (33-22) | 58-41 | Won 2 |
| » W: Mark Thurmond (8-5) L: Jeff Russell (4-12) | First | -- |
| Friday, July 27 |
| » Defeated Astros (48-54), 7-3 | San Diego/Jack Murphy Stadium (34-22) | 59-41 | Won 3 |
| » W: Ed Whitson (12-5) L: Vern Ruhle (1-8) S: Craig Lefferts (5) | First | -- |
| Saturday, July 28 |
| » Lost to Astros (49-54), 3-1 | San Diego/Jack Murphy Stadium (34-23) | 59-42 | |
| » W: Joe Niekro (11-8) L: Andy Hawkins (5-4) | First | -- |
| » Defeated Astros (49-55), 1-0 | San Diego/Jack Murphy Stadium (35-23) | 60-42 | |
| » W: Eric Show (11-6) L: Nolan Ryan (8-7) S: Rich Gossage (19) | First | -- |
| Sunday, July 29 |
| » Defeated Astros (49-56), 9-0 | San Diego/Jack Murphy Stadium (36-23) | 61-42 | Won 2 |
| » W: Tim Lollar (8-9) L: Mike LaCoss (5-2) | First | -- |
| Monday, July 30 |
| » Defeated Dodgers (52-54), 12-0 | San Diego/Jack Murphy Stadium (37-23) | 62-42 | Won 3 |
| » W: Dave Dravecky (8-5) L: Fernando Valenzuela (9-12) | First | -- |
| Tuesday, July 31 |
| » Defeated Dodgers (52-55), 1-0 | San Diego/Jack Murphy Stadium (38-23) | 63-42 | Won 4 |
| » W: Mark Thurmond (9-5) L: Rick Honeycutt (8-6) S: Rich Gossage (20) | First | -- |
| Wednesday, August 1 |
| » Defeated Dodgers (52-56), 4-3 | San Diego/Jack Murphy Stadium (39-23) | 64-42 | Won 5 |
| » W: Craig Lefferts (2-3) L: Alejandro Pena (11-6) S: Rich Gossage (21) | First | -- |
| Friday, August 3 |
| » Lost to Astros (51-58), 6-2 | Astrodome (2-2) | 64-43 | |
| » W: Nolan Ryan (9-7) L: Eric Show (11-7) | First | -- |
| Saturday, August 4 |
| » Defeated Astros (51-59), 5-2 | Astrodome (3-2) | 65-43 | |
| » W: Tim Lollar (9-9) L: Mike LaCoss (5-3) S: Craig Lefferts (6) | First | -- |
| Sunday, August 5 |
| » Defeated Astros (51-60), 9-5 | Astrodome (4-2) | 66-43 | Won 2 |
| » W: Andy Hawkins (6-4) L: Joe Niekro (11-9) | First | -- |
| Monday, August 6 |
| » Defeated Reds (46-65), 1-0 | Riverfront Stadium (3-1) | 67-43 | Won 3 |
| » W: Rich Gossage (6-3) L: Joe Price (5-8) | First | -- |
| Tuesday, August 7 |
| » Lost to Reds (47-65), 8-7 | Riverfront Stadium (3-2) | 67-44 | |
| » W: Ted Power (7-5) L: Greg Harris (0-2) | First | -- |
| Wednesday, August 8 |
| » Lost to Reds (48-65), 4-2 | Riverfront Stadium (3-3) | 67-45 | Lost 2 |
| » W: Mario Soto (12-5) L: Rich Gossage (6-4) | First | -- |
| Thursday, August 9 |
| » Lost to Reds (49-65), 8-0 | Riverfront Stadium (3-4) | 67-46 | Lost 3 |
| » W: Jeff Russell (5-12) L: Tim Lollar (9-10) | First | -- |
| Friday, August 10 |
| » Lost to Braves (59-56), 3-1 | Atlanta-Fulton County Stadium (1-2) | 67-47 | Lost 4 |
| » W: Steve Bedrosian (8-6) L: Dave Dravecky (8-6) S: Donnie Moore (14) | First | -- |
| » Defeated Braves (59-57), 10-4 | Atlanta-Fulton County Stadium (2-2) | 68-47 | |
| » W: Andy Hawkins (7-4) L: Pete Falcone (5-7) S: Rich Gossage (22) | First | -- |
| Saturday, August 11 |
| » Defeated Braves (59-58), 4-1 | Atlanta-Fulton County Stadium (3-2) | 69-47 | Won 2 |
| » W: Mark Thurmond (10-5) L: Rick Mahler (8-7) S: Craig Lefferts (7) | First | -- |
| Sunday, August 12 |
| » Lost to Braves (60-58), 5-3 | Atlanta-Fulton County Stadium (3-3) | 69-48 | |
| » W: Pascual Perez (11-4) L: Ed Whitson (12-6) | First | -- |
| Tuesday, August 14 |
| » Defeated Phillies (62-54), 3-2 | San Diego/Jack Murphy Stadium (40-23) | 70-48 | |
| » W: Eric Show (12-7) L: Jerry Koosman (12-10) S: Craig Lefferts (8) | First | -- |
| Wednesday, August 15 |
| » Defeated Phillies (62-55), 4-3 | San Diego/Jack Murphy Stadium (41-23) | 71-48 | Won 2 |
| » W: Rich Gossage (7-4) L: Al Holland (5-7) | First | -- |
| Thursday, August 16 |
| » Lost to Phillies (63-55), 8-3 | San Diego/Jack Murphy Stadium (41-24) | 71-49 | |
| » W: John Denny (5-3) L: Andy Hawkins (7-5) | First | -- |
| Friday, August 17 |
| » Lost to Expos (60-60), 8-4 | San Diego/Jack Murphy Stadium (41-25) | 71-50 | Lost 2 |
| » W: Steve Rogers (4-12) L: Mark Thurmond (10-6) S: Jeff Reardon (17) | First | -- |
| Sunday, August 19 |
| » Lost to Expos (61-60), 3-0 | San Diego/Jack Murphy Stadium (41-26) | 71-51 | Lost 3 |
| » W: Joe Hesketh (1-0) L: Ed Whitson (12-7) S: Jeff Reardon (18) | First | -- |
| Monday, August 20 |
| » Defeated Mets (68-54), 3-1 | San Diego/Jack Murphy Stadium (42-26) | 72-51 | |
| » W: Eric Show (13-7) L: Sid Fernandez (4-2) S: Rich Gossage (23) | First | -- |
| Tuesday, August 21 |
| » Defeated Mets (68-55), 7-4 | San Diego/Jack Murphy Stadium (43-26) | 73-51 | Won 2 |
| » W: Tim Lollar (10-10) L: Ed Lynch (8-8) S: Rich Gossage (24) | First | -- |
| Wednesday, August 22 |
| » Lost to Mets (69-55), 5-2 | San Diego/Jack Murphy Stadium (43-27) | 73-52 | |
| » W: Dwight Gooden (12-8) L: Andy Hawkins (7-6) | First | -- |
| Friday, August 24 |
| » Lost to Expos (64-61), 4-1 | Stade Olympique (1-2) | 73-53 | Lost 2 |
| » W: Steve Rogers (5-12) L: Mark Thurmond (10-7) S: Jeff Reardon (19) | First | -- |
| » Defeated Expos (64-62), 5-4 | Stade Olympique (2-2) | 74-53 | |
| » W: Rich Gossage (8-4) L: Jeff Reardon (5-5) S: Greg Harris (3) | First | -- |
| Saturday, August 25 |
| » Defeated Expos (64-63), 4-3 | Stade Olympique (3-2) | 75-53 | Won 2 |
| » W: Greg Harris (1-2) L: Jeff Reardon (5-6) S: Rich Gossage (25) | First | -- |
| Sunday, August 26 |
| » Defeated Expos (64-64), 2-1 | Stade Olympique (4-2) | 76-53 | Won 3 |
| » W: Eric Show (14-7) L: Dan Schatzeder (6-5) | First | -- |
| Monday, August 27 |
| » Lost to Phillies (70-58), 9-1 | Veteran's Stadium (2-2) | 76-54 | |
| » W: Jerry Koosman (14-10) L: Tim Lollar (10-11) | First | -- |
| Tuesday, August 28 |
| » Lost to Phillies (71-58), 11-8 | Veteran's Stadium (2-3) | 76-55 | Lost 2 |
| » W: Shane Rawley (9-6) L: Andy Hawkins (7-7) S: Al Holland (28) | First | -- |
| Wednesday, August 29 |
| » Defeated Phillies (71-59), 2-0 | Veteran's Stadium (3-3) | 77-55 | |
| » W: Mark Thurmond (11-7) L: John Denny (6-5) | First | -- |
| Friday, August 31 |
| » Defeated Mets (73-59), 5-1 | Shea Stadium (2-0) | 78-55 | Won 2 |
| » W: Ed Whitson (13-7) L: Sid Fernandez (4-3) S: Craig Lefferts (9) | First | -- |
| » Lost to Mets (74-59), 4-0 | Shea Stadium (2-1) | 78-56 | |
| » W: Bruce Berenyi (10-13) L: Dave Dravecky (8-7) | First | -- |
| Saturday, September 1 |
| » Lost to Mets (75-59), 7-4 | Shea Stadium (2-2) | 78-57 | Lost 2 |
| » W: Dwight Gooden (14-8) L: Andy Hawkins (7-8) S: Jesse Orosco (28) | First | -- |
| » Lost to Mets (76-59), 10-6 | Shea Stadium (2-3) | 78-58 | Lost 3 |
| » W: Tom Gorman (4-0) L: Eric Show (14-8) S: Jesse Orosco (29) | First | -- |
| » Major-league debuts: Calvin Schiraldi and Herm Winningham (Mets) |
| Sunday, September 2 |
| » Lost to Mets (77-59), 3-2 | Shea Stadium (2-4) | 78-59 | Lost 4 |
| » W: Brent Gaff (3-2) L: Rich Gossage (8-5) | First | -- |
| Monday, September 3 |
| » Defeated Dodgers (64-74), 4-3 | Dodger Stadium (4-4) | 79-59 | |
| » W: Mark Thurmond (12-7) L: Jerry Reuss (2-7) S: Craig Lefferts (10) | First | -- |
| Tuesday, September 4 |
| » Lost to Dodgers (65-74), 2-1 | Dodger Stadium (4-5) | 79-60 | |
| » W: Ken Howell (3-4) L: Andy Hawkins (7-9) | First | -- |
| Wednesday, September 5 |
| » Defeated Reds (58-82), 15-11 | San Diego/Jack Murphy Stadium (44-27) | 80-60 | |
| » W: Craig Lefferts (3-3) L: Tom Hume (4-13) | First | -- |
| Thursday, September 6 |
| » Lost to Reds (59-82), 10-3 | San Diego/Jack Murphy Stadium (44-28) | 80-61 | |
| » W: Joe Price (7-11) L: Eric Show (14-9) S: Bob Owchinko (2) | First | -- |
| Friday, September 7 |
| » Lost to Astros (72-70), 6-4 | San Diego/Jack Murphy Stadium (44-29) | 80-62 | Lost 2 |
| » W: Joe Niekro (14-10) L: Tim Lollar (10-12) S: Frank DiPino (13) | First | -- |
| Sunday, September 9 |
| » Defeated Astros (72-71), 8-4 | San Diego/Jack Murphy Stadium (45-29) | 81-62 | |
| » W: Mark Thurmond (13-7) L: Mike LaCoss (7-4) | First | -- |
| Tuesday, September 11 |
| » Lost to Dodgers (68-77), 5-2 | San Diego/Jack Murphy Stadium (45-30) | 81-63 | |
| » W: Fernando Valenzuela (12-15) L: Ed Whitson (13-8) | First | -- |
| Wednesday, September 12 |
| » Lost to Dodgers (69-77), 8-1 | San Diego/Jack Murphy Stadium (45-31) | 81-64 | Lost 2 |
| » W: Burt Hooton (3-4) L: Dave Dravecky (8-8) | First | -- |
| Friday, September 14 |
| » Defeated Astros (72-75), 4-2 | Astrodome (5-2) | 82-64 | |
| » W: Rich Gossage (9-5) L: Frank DiPino (4-9) | First | -- |
| Saturday, September 15 |
| » Lost to Astros (73-75), 3-2 | Astrodome (5-3) | 82-65 | |
| » W: Bill Dawley (9-4) L: Craig Lefferts (3-4) | First | -- |
| Sunday, September 16 |
| » Lost to Astros (74-75), 10-9 | Astrodome (5-4) | 82-66 | Lost 2 |
| » W: Dave Smith (4-3) L: Rich Gossage (9-6) | First | -- |
| Monday, September 17 |
| » Defeated Reds (63-87), 3-2 | Riverfront Stadium (4-4) | 83-66 | |
| » W: Rich Gossage (10-6) L: Ted Power (8-6) | First | -- |
| Tuesday, September 18 |
| » Defeated Reds (63-88), 2-0 | Riverfront Stadium (5-4) | 84-66 | Won 2 |
| » W: Dave Dravecky (9-8) L: Joe Price (7-12) | First | -- |
| Wednesday, September 19 |
| » Defeated Giants (62-89), 5-4 | San Diego/Jack Murphy Stadium (46-31) | 85-66 | Won 3 |
| » W: Andy Hawkins (8-9) L: Scott Garrelts (1-3) | First | -- |
| Thursday, September 20 |
| » Defeated Giants (62-90), 5-4 | San Diego/Jack Murphy Stadium (47-31) | 86-66 | Won 4 |
| » W: Tim Lollar (11-12) L: Mike Krukow (10-12) S: Dave Dravecky (8) | First | -- |
| Friday, September 21 |
| » Lost to Braves (77-77), 3-1 | San Diego/Jack Murphy Stadium (47-32) | 86-67 | |
| » W: Rick Mahler (12-9) L: Mark Thurmond (13-8) | First | -- |
| Saturday, September 22 |
| » Lost to Braves (78-77), 5-2 | San Diego/Jack Murphy Stadium (47-33) | 86-68 | Lost 2 |
| » W: Pascual Perez (13-7) L: Luis DeLeon (1-2) S: Gene Garber (10) | First | -- |
| Sunday, September 23 |
| » Defeated Braves (78-78), 2-1 | San Diego/Jack Murphy Stadium (48-33) | 87-68 | |
| » W: Greg Booker (1-0) L: Donnie Moore (4-5) | First | -- |
| Monday, September 24 |
| » Defeated Giants (65-91), 7-1 | Candlestick Park (5-1) | 88-68 | Won 2 |
| » W: Greg Harris (2-2) L: Jeff Robinson (7-15) | First | -- |
| » Defeated Giants (65-92), 8-6 | Candlestick Park (6-1) | 89-68 | Won 3 |
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