| Sunday, March 18 |
| Former Oriole Charlie Lau dies in Key Colony Beach, FL at the age of 51. |
| Monday, April 2 |
| » Lost to White Sox (1-0), 5-2 | Memorial Stadium (0-1) | 0-1 | |
| » W: La Marr Hoyt (1-0) L: Scott McGregor (0-1) S: Britt Burns (1) | Second | ½ out |
| Friday, April 6 |
| » Lost to Twins (1-2), 9-4 | Hubert H. Humphrey Metrodome (0-1) | 0-2 | Lost 2 |
| » W: Mike Smithson (1-0) L: Mike Boddicker (0-1) | Fifth | 2½ out |
| Saturday, April 7 |
| » Lost to Twins (2-2), 13-4 | Hubert H. Humphrey Metrodome (0-2) | 0-3 | Lost 3 |
| » W: John Butcher (1-0) L: Mike Flanagan (0-1) | Sixth | 3½ out |
| Sunday, April 8 |
| » Lost to Twins (3-2), 7-3 | Hubert H. Humphrey Metrodome (0-3) | 0-4 | Lost 4 |
| » W: Albert Williams (1-1) L: Jim Palmer (0-1) S: Ron Davis (1) | Sixth | 4½ out |
| Tuesday, April 10 |
| » Defeated Royals (3-3), 6-3 | Memorial Stadium (1-1) | 1-4 | |
| » W: Scott McGregor (1-1) L: Paul Splittorff (0-2) S: Storm Davis (1) | Fifth | 4½ out |
| Wednesday, April 11 |
| » Lost to Royals (4-3), 5-2 | Memorial Stadium (1-2) | 1-5 | |
| » W: Larry Gura (2-0) L: Mike Boddicker (0-2) S: Dan Quisenberry (3) | Sixth | 5 out |
| Saturday, April 14 |
| » Lost to Indians (4-3), 8-2 | Cleveland Stadium (0-1) | 1-6 | Lost 2 |
| » W: Rick Sutcliffe (2-0) L: Scott McGregor (1-2) | Sixth | 6½ out |
| Sunday, April 15 |
| » Defeated Indians (4-4), 6-5 | Cleveland Stadium (1-1) | 2-6 | |
| » W: Sammy Stewart (1-0) L: George Frazier (0-2) | Seventh | 6 out |
| » Major-league debuts: Tom Waddell (Indians) |
| Monday, April 16 |
| » Lost to Indians (5-4), 4-3 | Cleveland Stadium (1-2) | 2-7 | |
| » W: Bert Blyleven (2-1) L: Mike Flanagan (0-2) S: Ernie Camacho (1) | Seventh | 6½ out |
| Tuesday, April 17 |
| » Lost to Blue Jays (7-4), 3-2 | Exhibition Stadium (0-1) | 2-8 | Lost 2 |
| » W: Jimmy Key (2-0) L: Tippy Martinez (0-1) S: Dennis Lamp (2) | Seventh | 7 out |
| Wednesday, April 18 |
| » Lost to Blue Jays (8-4), 7-1 | Exhibition Stadium (0-2) | 2-9 | Lost 3 |
| » W: Dave Stieb (2-0) L: Jim Palmer (0-2) | Seventh | 8 out |
| Thursday, April 19 |
| » Lost to Blue Jays (9-4), 2-1 | Exhibition Stadium (0-3) | 2-10 | Lost 4 |
| » W: Jim Clancy (1-1) L: Scott McGregor (1-3) | Seventh | 8 out |
| Friday, April 20 |
| » Defeated Twins (7-7), 4-2 | Memorial Stadium (2-2) | 3-10 | |
| » W: Sammy Stewart (2-0) L: Ron Davis (2-1) | Sixth | 8 out |
| Saturday, April 21 |
| » Defeated Twins (7-8), 5-3 | Memorial Stadium (3-2) | 4-10 | Won 2 |
| » W: Mike Flanagan (1-2) L: Mike Smithson (3-1) S: Tippy Martinez (1) | Sixth | 8 out |
| Sunday, April 22 |
| » Lost to Twins (8-8), 6-1 | Memorial Stadium (3-3) | 4-11 | |
| » W: John Butcher (2-1) L: Mike Boddicker (0-3) | Seventh | 9 out |
| Monday, April 23 |
| » Lost to White Sox (6-8), 7-6 | Comiskey Park I (0-1) | 4-12 | Lost 2 |
| » W: Britt Burns (1-1) L: Tippy Martinez (0-2) | Seventh | 9½ out |
| Tuesday, April 24 |
| » Defeated White Sox (6-9), 8-3 | Comiskey Park I (1-1) | 5-12 | |
| » W: Scott McGregor (2-3) L: Richard Dotson (2-2) | Seventh | 10 out |
| Wednesday, April 25 |
| » Lost to Royals (8-8), 3-2 | Royals Stadium (0-1) | 5-13 | |
| » W: Dan Quisenberry (1-1) L: Tippy Martinez (0-3) | Seventh | 11 out |
| Thursday, April 26 |
| » Defeated Royals (8-9), 11-3 | Royals Stadium (1-1) | 6-13 | |
| » W: Mike Flanagan (2-2) L: Danny Jackson (0-2) | Sixth | 11 out |
| Friday, April 27 |
| » Defeated Rangers (8-12), 4-3 | Memorial Stadium (4-3) | 7-13 | Won 2 |
| » W: Sammy Stewart (3-0) L: Dave Tobik (1-3) | Seventh | 10 out |
| Saturday, April 28 |
| » Defeated Rangers (8-13), 6-1 | Memorial Stadium (5-3) | 8-13 | Won 3 |
| » W: Scott McGregor (3-3) L: Charlie Hough (1-3) | Sixth | 10 out |
| Sunday, April 29 |
| » Defeated Rangers (8-14), 3-2 | Memorial Stadium (6-3) | 9-13 | Won 4 |
| » W: Storm Davis (1-0) L: Dave Stewart (0-6) S: Tippy Martinez (2) | Fifth | 10 out |
| Monday, April 30 |
| » Defeated Indians (10-9), 6-3 | Memorial Stadium (7-3) | 10-13 | Won 5 |
| » W: Sammy Stewart (4-0) L: Ernie Camacho (0-1) S: Tippy Martinez (3) | Fifth | 9½ out |
| Tuesday, May 1 |
| » Defeated Indians (10-10), 3-0 | Memorial Stadium (8-3) | 11-13 | Won 6 |
| » W: Mike Boddicker (1-3) L: Bert Blyleven (3-2) | Fourth | 9½ out |
| Wednesday, May 2 |
| » Lost to Indians (11-10), 9-7 | Memorial Stadium (8-4) | 11-14 | |
| » W: George Frazier (2-2) L: Jim Palmer (0-3) | Fourth | 9½ out |
| Friday, May 4 |
| » Defeated Rangers (9-17), 2-0 | Arlington Stadium (1-0) | 12-14 | |
| » W: Storm Davis (2-0) L: Dave Schmidt (0-1) | Fifth | 9 out |
| Saturday, May 5 |
| » Defeated Rangers (9-18), 7-5 | Arlington Stadium (2-0) | 13-14 | Won 2 |
| » W: Dennis Martinez (1-0) L: Ricky Wright (0-1) S: Tippy Martinez (4) | Fourth | 9 out |
| Sunday, May 6 |
| » Defeated Rangers (9-19), 6-1 | Arlington Stadium (3-0) | 14-14 | Won 3 |
| » W: Mike Boddicker (2-3) L: Frank Tanana (2-4) | Third | 9 out |
| Wednesday, May 9 |
| » Defeated Blue Jays (18-11), 7-4 | Memorial Stadium (9-4) | 15-14 | Won 4 |
| » W: Scott McGregor (4-3) L: Jim Clancy (2-3) | Third | 9½ out |
| » Defeated Blue Jays (18-12), 7-3 | Memorial Stadium (10-4) | 16-14 | Won 5 |
| » W: Tippy Martinez (1-3) L: Jimmy Key (2-2) | Third | 9½ out |
| Thursday, May 10 |
| » Lost to Blue Jays (19-12), 4-3 | Memorial Stadium (10-5) | 16-15 | |
| » W: Roy Lee Jackson (2-1) L: Dennis Martinez (1-1) | Third | 10 out |
| Friday, May 11 |
| » Defeated Athletics (17-16), 4-3 | Memorial Stadium (11-5) | 17-15 | |
| » W: Mike Boddicker (3-3) L: Mike Warren (3-5) S: Tippy Martinez (5) | Third | 10 out |
| Saturday, May 12 |
| » Lost to Athletics (18-16), 12-2 | Memorial Stadium (11-6) | 17-16 | |
| » W: Bill Krueger (1-0) L: Dennis Martinez (1-2) | Third | 10 out |
| Sunday, May 13 |
| » Defeated Athletics (18-17), 5-1 | Memorial Stadium (12-6) | 18-16 | |
| » W: Storm Davis (3-0) L: Steve McCatty (3-2) | Third | 9½ out |
| Monday, May 14 |
| » Defeated Angels (19-18), 4-1 | Memorial Stadium (13-6) | 19-16 | Won 2 |
| » W: Scott McGregor (5-3) L: Geoff Zahn (4-3) | Third | 9½ out |
| Tuesday, May 15 |
| » Lost to Angels (20-18), 5-2 | Memorial Stadium (13-7) | 19-17 | |
| » W: Ron Romanick (4-3) L: Mike Flanagan (2-3) S: Luis Sanchez (4) | Third | 10½ out |
| Wednesday, May 16 |
| » Defeated Angels (20-19), 5-0 | Memorial Stadium (14-7) | 20-17 | |
| » W: Mike Boddicker (4-3) L: Mike Witt (4-3) | Third | 10½ out |
| Friday, May 18 |
| » Defeated Mariners (18-21), 4-1 | Memorial Stadium (15-7) | 21-17 | Won 2 |
| » W: Storm Davis (4-0) L: Jim Beattie (3-4) | Third | 10½ out |
| Saturday, May 19 |
| » Lost to Mariners (19-21), 6-5 | Memorial Stadium (15-8) | 21-18 | |
| » W: Ed Vande Berg (3-2) L: Tippy Martinez (1-4) | Third | 11½ out |
| Sunday, May 20 |
| » Defeated Mariners (19-22), 5-1 | Memorial Stadium (16-8) | 22-18 | |
| » W: Mike Flanagan (3-3) L: Mike Moore (1-3) S: Tippy Martinez (6) | Third | 11½ out |
| Tuesday, May 22 |
| » Lost to Athletics (19-23), 6-4 | Oakland-Alameda County Stadium (0-1) | 22-19 | |
| » W: Ray Burris (3-2) L: Mike Boddicker (4-4) S: Bill Caudill (7) | Third | 12½ out |
| Wednesday, May 23 |
| » Defeated Athletics (19-24), 9-5 | Oakland-Alameda County Stadium (1-1) | 23-19 | |
| » W: Bill Swaggerty (1-0) L: Mike Warren (3-6) S: Tippy Martinez (7) | Third | 12½ out |
| Thursday, May 24 |
| » Lost to Athletics (20-24), 3-2 | Oakland-Alameda County Stadium (1-2) | 23-20 | |
| » W: Bill Krueger (2-1) L: Storm Davis (4-1) S: Bill Caudill (8) | Third | 13½ out |
| Friday, May 25 |
| » Lost to Angels (24-22), 10-2 | Anaheim Stadium (0-1) | 23-21 | Lost 2 |
| » W: Ron Romanick (6-3) L: Mike Flanagan (3-4) | Third | 13½ out |
| Saturday, May 26 |
| » Defeated Angels (24-23), 9-5 | Anaheim Stadium (1-1) | 24-21 | |
| » W: Mike Boddicker (5-4) L: Craig Swan (1-1) | Third | 12½ out |
| Sunday, May 27 |
| » Defeated Angels (24-24), 8-0 | Anaheim Stadium (2-1) | 25-21 | Won 2 |
| » W: Scott McGregor (6-3) L: Mike Witt (4-5) | Third | 11½ out |
| Monday, May 28 |
| » Defeated Mariners (23-25), 7-4 | Kingdome (1-0) | 26-21 | Won 3 |
| » W: Storm Davis (5-1) L: Jim Beattie (3-6) | Third | 11½ out |
| Tuesday, May 29 |
| » Defeated Mariners (23-26), 3-2 | Kingdome (2-0) | 27-21 | Won 4 |
| » W: Tippy Martinez (2-4) L: Paul Mirabella (1-2) | Third | 10½ out |
| Wednesday, May 30 |
| » Defeated Mariners (23-27), 8-2 | Kingdome (3-0) | 28-21 | Won 5 |
| » W: Mike Boddicker (6-4) L: Ed Vande Berg (4-3) | Third | 10½ out |
| Friday, June 1 |
| » Lost to Tigers (38-9), 14-2 | Tiger Stadium (0-1) | 28-22 | |
| » W: Dan Petry (8-2) L: Scott McGregor (6-4) S: Doug Bair (3) | Third | 11½ out |
| Saturday, June 2 |
| » Defeated Tigers (38-10), 5-0 | Tiger Stadium (1-1) | 29-22 | |
| » W: Storm Davis (6-1) L: Jack Morris (10-2) | Third | 10½ out |
| Sunday, June 3 |
| » Defeated Tigers (38-11), 2-1 | Tiger Stadium (2-1) | 30-22 | Won 2 |
| » W: Mike Flanagan (4-4) L: Milt Wilcox (6-3) | Third | 9½ out |
| Monday, June 4 |
| » Defeated Brewers (22-28), 6-2 | Memorial Stadium (17-8) | 31-22 | Won 3 |
| » W: Mike Boddicker (7-4) L: Pete Ladd (2-4) | Third | 9½ out |
| » Major-league debuts: Jack Lazorko (Brewers) |
| Tuesday, June 5 |
| » Lost to Brewers (23-28), 8-3 | Memorial Stadium (17-9) | 31-23 | |
| » W: Jaime Cocanower (5-5) L: Bill Swaggerty (1-1) | Third | 9½ out |
| Wednesday, June 6 |
| » Defeated Brewers (23-29), 3-0 | Memorial Stadium (18-9) | 32-23 | |
| » W: Scott McGregor (7-4) L: Don Sutton (3-5) | Third | 8½ out |
| Friday, June 8 |
| » Lost to Tigers (41-13), 3-2 | Memorial Stadium (18-10) | 32-24 | |
| » W: Milt Wilcox (7-3) L: Storm Davis (6-2) S: Willie Hernandez (8) | Third | 10 out |
| Saturday, June 9 |
| » Defeated Tigers (41-14), 4-0 | Memorial Stadium (19-10) | 33-24 | |
| » W: Mike Flanagan (5-4) L: Juan Berenguer (3-4) | Third | 9 out |
| » Major-league debuts: Carl Willis (Tigers) |
| Sunday, June 10 |
| » Lost to Tigers (42-14), 10-4 | Memorial Stadium (19-11) | 33-25 | |
| » W: Doug Bair (3-0) L: Mike Boddicker (7-5) S: Willie Hernandez (9) | Third | 11 out |
| » Lost to Tigers (43-14), 8-0 | Memorial Stadium (19-12) | 33-26 | Lost 2 |
| » W: Dan Petry (9-3) L: Dennis Martinez (1-3) | Third | 11 out |
| Monday, June 11 |
| » Defeated Brewers (24-33), 3-1 | County Stadium (1-0) | 34-26 | |
| » W: Scott McGregor (8-4) L: Don Sutton (3-6) | Third | 11 out |
| Tuesday, June 12 |
| » Defeated Brewers (24-34), 5-4 | County Stadium (2-0) | 35-26 | Won 2 |
| » W: Tippy Martinez (3-4) L: Rollie Fingers (0-2) S: Sammy Stewart (1) | Third | 10 out |
| Wednesday, June 13 |
| » Lost to Brewers (25-34), 6-1 | County Stadium (2-1) | 35-27 | |
| » W: Moose Haas (4-5) L: Mike Flanagan (5-5) | Third | 10 out |
| Thursday, June 14 |
| » Lost to Brewers (26-34), 3-2 | County Stadium (2-2) | 35-28 | Lost 2 |
| » W: Rick Waits (1-2) L: Storm Davis (6-3) S: Rollie Fingers (11) | Third | 10½ out |
| Friday, June 15 |
| » Defeated Yankees (27-34), 2-1 | Yankee Stadium (1-0) | 36-28 | |
| » W: Mike Boddicker (8-5) L: Bob Shirley (1-1) S: Tippy Martinez (8) | Third | 10½ out |
| Saturday, June 16 |
| » Lost to Yankees (28-34), 8-3 | Yankee Stadium (1-1) | 36-29 | |
| » W: Jay Howell (2-4) L: Scott McGregor (8-5) | Third | 11½ out |
| Sunday, June 17 |
| » Defeated Yankees (28-35), 6-2 | Yankee Stadium (2-1) | 37-29 | |
| » W: Mike Flanagan (6-5) L: Dennis Rasmussen (1-2) | Third | 11½ out |
| Tuesday, June 19 |
| » Defeated Red Sox (31-34), 9-7 | Fenway Park (1-0) | 38-29 | Won 2 |
| » W: Bill Swaggerty (2-1) L: Bob Stanley (1-6) S: Tippy Martinez (9) | Third | 11 out |
| Wednesday, June 20 |
| » Defeated Red Sox (31-35), 4-1 | Fenway Park (2-0) | 39-29 | Won 3 |
| » W: Mike Boddicker (9-5) L: Oil Can Boyd (1-5) | Third | 11 out |
| Thursday, June 21 |
| » Lost to Yankees (30-37), 5-3 | Memorial Stadium (19-13) | 39-30 | |
| » W: Shane Rawley (2-3) L: Scott McGregor (8-6) S: Clay Christiansen (1) | Third | 11 out |
| Friday, June 22 |
| » Defeated Yankees (30-38), 5-4 | Memorial Stadium (20-13) | 40-30 | |
| » W: Mike Flanagan (7-5) L: Dennis Rasmussen (1-3) S: Tippy Martinez (10) | Third | 11 out |
| Saturday, June 23 |
| » Lost to Yankees (31-38), 5-4 | Memorial Stadium (20-14) | 40-31 | |
| » W: Jose Rijo (2-7) L: Tippy Martinez (3-5) S: Clay Christiansen (2) | Third | 12 out |
| Monday, June 25 |
| » Lost to Red Sox (34-37), 7-4 | Memorial Stadium (20-15) | 40-32 | Lost 2 |
| » W: Oil Can Boyd (2-5) L: Storm Davis (6-4) S: Mark Clear (1) | Third | 12½ out |
| Tuesday, June 26 |
| » Lost to Red Sox (35-37), 5-2 | Memorial Stadium (20-16) | 40-33 | Lost 3 |
| » W: Al Nipper (1-2) L: Mike Boddicker (9-6) S: Bob Stanley (13) | Third | 13½ out |
| Wednesday, June 27 |
| » Defeated Red Sox (35-38), 3-1 | Memorial Stadium (21-16) | 41-33 | |
| » W: Scott McGregor (9-6) L: Roger Clemens (3-2) S: Sammy Stewart (2) | Third | 12½ out |
| Thursday, June 28 |
| » Defeated White Sox (35-39), 2-0 | Comiskey Park I (2-1) | 42-33 | Won 2 |
| » W: Mike Flanagan (8-5) L: Tom Seaver (6-6) S: Tippy Martinez (11) | Third | 12 out |
| Friday, June 29 |
| » Lost to White Sox (36-39), 2-1 | Comiskey Park I (2-2) | 42-34 | |
| » W: Richard Dotson (10-4) L: Dennis Martinez (1-4) | Third | 12½ out |
| Saturday, June 30 |
| » Lost to White Sox (37-39), 5-4 | Comiskey Park I (2-3) | 42-35 | Lost 2 |
| » W: Al Jones (1-1) L: Sammy Stewart (4-1) | Third | 13½ out |
| Sunday, July 1 |
| » Defeated White Sox (37-40), 8-3 | Comiskey Park I (3-3) | 43-35 | |
| » W: Mike Boddicker (10-6) L: La Marr Hoyt (7-8) | Third | 12½ out |
| Monday, July 2 |
| » Lost to Twins (39-39), 6-4 | Hubert H. Humphrey Metrodome (0-4) | 43-36 | |
| » W: John Butcher (6-5) L: Scott McGregor (9-7) | Third | 12½ out |
| Tuesday, July 3 |
| » Lost to Twins (40-39), 3-1 | Hubert H. Humphrey Metrodome (0-5) | 43-37 | Lost 2 |
| » W: Mike Smithson (9-7) L: Mike Flanagan (8-6) | Third | 12½ out |
| Wednesday, July 4 |
| » Defeated Twins (40-40), 6-4 | Hubert H. Humphrey Metrodome (1-5) | 44-37 | |
| » W: Dennis Martinez (2-4) L: Albert Williams (3-4) S: Tippy Martinez (12) | Third | 11½ out |
| Friday, July 6 |
| » Lost to Royals (38-41), 6-2 | Memorial Stadium (21-17) | 44-38 | |
| » W: Charlie Leibrandt (4-3) L: Mike Boddicker (10-7) S: Dan Quisenberry (23) | Third | 12 out |
| Saturday, July 7 |
| » Defeated Royals (38-42), 6-2 | Memorial Stadium (22-17) | 45-38 | |
| » W: Scott McGregor (10-7) L: Larry Gura (9-5) | Third | 11½ out |
| » Defeated Royals (38-43), 8-0 | Memorial Stadium (23-17) | 46-38 | Won 2 |
| » W: Mike Flanagan (9-6) L: Mike Jones (0-1) | Third | 11½ out |
| Sunday, July 8 |
| » Lost to Royals (39-43), 6-1 | Memorial Stadium (23-18) | 46-39 | |
| » W: Bud Black (10-6) L: Dennis Martinez (2-5) | Third | 11½ out |
| Thursday, July 12 |
| » Defeated White Sox (44-41), 2-1 | Memorial Stadium (24-18) | 47-39 | |
| » W: Storm Davis (7-4) L: La Marr Hoyt (8-9) S: Sammy Stewart (3) | Third | 10 out |
| » Defeated White Sox (44-42), 3-0 | Memorial Stadium (25-18) | 48-39 | Won 2 |
| » W: Scott McGregor (11-7) L: Gene Nelson (1-1) | Third | 10 out |
| Friday, July 13 |
| » Defeated White Sox (44-43), 7-5 | Memorial Stadium (26-18) | 49-39 | Won 3 |
| » W: Tippy Martinez (4-5) L: Ron Reed (0-4) | Third | 10 out |
| Saturday, July 14 |
| » Lost to White Sox (45-43), 3-2 | Memorial Stadium (26-19) | 49-40 | |
| » W: Tom Seaver (8-6) L: Mike Flanagan (9-7) | Third | 11 out |
| Sunday, July 15 |
| » Defeated White Sox (45-44), 6-4 | Memorial Stadium (27-19) | 50-40 | |
| » W: Dennis Martinez (3-5) L: Richard Dotson (11-5) S: Tippy Martinez (13) | Third | 11 out |
| Monday, July 16 |
| » Defeated Twins (44-45), 3-1 | Memorial Stadium (28-19) | 51-40 | Won 2 |
| » W: Storm Davis (8-4) L: Mike Smithson (9-8) | Third | 11 out |
| Tuesday, July 17 |
| » Defeated Twins (44-46), 3-1 | Memorial Stadium (29-19) | 52-40 | Won 3 |
| » W: Scott McGregor (12-7) L: Frank Viola (10-8) | Third | 11 out |
| Wednesday, July 18 |
| » Lost to Twins (45-46), 3-1 | Memorial Stadium (29-20) | 52-41 | |
| » W: John Butcher (7-6) L: Mike Boddicker (10-8) | Third | 11 out |
| Thursday, July 19 |
| » Lost to Royals (41-51), 6-3 | Royals Stadium (1-2) | 52-42 | Lost 2 |
| » W: Mark Gubicza (6-8) L: Mike Flanagan (9-8) | Third | 12 out |
| Friday, July 20 |
| » Lost to Royals (42-51), 4-3 | Royals Stadium (1-3) | 52-43 | Lost 3 |
| » W: Bret Saberhagen (4-8) L: Tippy Martinez (4-6) S: Dan Quisenberry (25) | Third | 13 out |
| Saturday, July 21 |
| » Defeated Royals (42-52), 4-3 | Royals Stadium (2-3) | 53-43 | |
| » W: Storm Davis (9-4) L: Mark Huismann (1-3) S: Sammy Stewart (4) | Third | 13 out |
| Sunday, July 22 |
| » Lost to Royals (43-52), 8-4 | Royals Stadium (2-4) | 53-44 | |
| » W: Larry Gura (10-7) L: Scott McGregor (12-8) | Third | 14 out |
| Monday, July 23 |
| » Defeated Rangers (40-59), 9-5 | Arlington Stadium (4-0) | 54-44 | |
| » W: Mike Boddicker (11-8) L: Mike Mason (6-9) S: Tippy Martinez (14) | Third | 14 out |
| » Major-league debuts: Jeff Kunkel (Rangers) |
| Tuesday, July 24 |
| » Lost to Rangers (41-59), 3-2 | Arlington Stadium (4-1) | 54-45 | |
| » W: Danny Darwin (6-5) L: Mike Flanagan (9-9) | Third | 15 out |
| Wednesday, July 25 |
| » Defeated Rangers (41-60), 3-1 | Arlington Stadium (5-1) | 55-45 | |
| » W: Dennis Martinez (4-5) L: Frank Tanana (9-10) S: Sammy Stewart (5) | Third | 14 out |
| Friday, July 27 |
| » Defeated Indians (42-56), 4-3 | Memorial Stadium (30-20) | 56-45 | Won 2 |
| » W: Storm Davis (10-4) L: Neal Heaton (7-10) | Third | 13½ out |
| Saturday, July 28 |
| » Lost to Indians (43-56), 6-3 | Memorial Stadium (30-21) | 56-46 | |
| » W: Bert Blyleven (10-4) L: Scott McGregor (12-9) S: Tom Waddell (4) | Third | 13½ out |
| Sunday, July 29 |
| » Defeated Indians (43-57), 3-1 | Memorial Stadium (31-21) | 57-46 | |
| » W: Mike Boddicker (12-8) L: Steve Comer (2-5) S: Sammy Stewart (6) | Third | 13½ out |
| Monday, July 30 |
| » Lost to Rangers (44-61), 5-1 | Memorial Stadium (31-22) | 57-47 | |
| » W: Frank Tanana (10-10) L: Mike Flanagan (9-10) | Third | 14 out |
| Tuesday, July 31 |
| » Lost to Rangers (45-61), 7-6 | Memorial Stadium (31-23) | 57-48 | Lost 2 |
| » W: Odell Jones (2-4) L: Tippy Martinez (4-7) S: Dave Schmidt (7) | Third | 14½ out |
| Wednesday, August 1 |
| » Defeated Rangers (45-62), 7-2 | Memorial Stadium (32-23) | 58-48 | |
| » W: Storm Davis (11-4) L: Charlie Hough (11-9) | Third | 13½ out |
| Friday, August 3 |
| » Lost to Blue Jays (61-45), 5-2 | Memorial Stadium (32-24) | 58-49 | |
| » W: Roy Lee Jackson (7-3) L: Scott McGregor (12-10) | Third | 14 out |
| Saturday, August 4 |
| » Lost to Blue Jays (62-45), 6-2 | Memorial Stadium (32-25) | 58-50 | Lost 2 |
| » W: Jim Clancy (8-11) L: Mike Flanagan (9-11) | Third | 14 out |
| Sunday, August 5 |
| » Lost to Blue Jays (63-45), 4-3 | Memorial Stadium (32-26) | 58-51 | Lost 3 |
| » W: Jimmy Key (3-4) L: Tippy Martinez (4-8) S: Dennis Lamp (9) | Third | 13½ out |
| Monday, August 6 |
| » Defeated Indians (45-64), 4-2 | Cleveland Stadium (2-2) | 59-51 | |
| » W: Storm Davis (12-4) L: Steve Farr (2-8) | Third | 13 out |
| Tuesday, August 7 |
| » Lost to Indians (46-64), 5-4 | Cleveland Stadium (2-3) | 59-52 | |
| » W: Bert Blyleven (11-5) L: Scott McGregor (12-11) S: Ernie Camacho (14) | Third | 13½ out |
| Wednesday, August 8 |
| » Defeated Indians (46-65), 7-4 | Cleveland Stadium (3-3) | 60-52 | |
| » W: Mike Boddicker (13-8) L: Steve Comer (2-7) S: Tippy Martinez (15) | Third | 12½ out |
| Thursday, August 9 |
| » Lost to Indians (47-65), 7-5 | Cleveland Stadium (3-4) | 60-53 | |
| » W: Jamie Easterly (2-0) L: Mark Brown (0-1) S: Ernie Camacho (15) | Third | 13 out |
| Friday, August 10 |
| » Lost to Blue Jays (65-47), 2-0 | Exhibition Stadium (0-4) | 60-54 | Lost 2 |
| » W: Doyle Alexander (10-5) L: Dennis Martinez (4-6) | Third | 14 out |
| Saturday, August 11 |
| » Lost to Blue Jays (66-47), 3-2 | Exhibition Stadium (0-5) | 60-55 | Lost 3 |
| » W: Jim Gott (6-5) L: Storm Davis (12-5) | Fourth | 15 out |
| Sunday, August 12 |
| » Defeated Blue Jays (66-48), 5-4 | Exhibition Stadium (1-5) | 61-55 | |
| » W: Scott McGregor (13-11) L: Roy Lee Jackson (7-5) S: Tippy Martinez (16) | Third | 15 out |
| Monday, August 13 |
| » Defeated Blue Jays (66-49), 2-1 | Exhibition Stadium (2-5) | 62-55 | Won 2 |
| » W: Mike Boddicker (14-8) L: Jim Clancy (9-12) | Third | 14½ out |
| Tuesday, August 14 |
| » Lost to Athletics (57-63), 4-3 | Memorial Stadium (32-27) | 62-56 | |
| » W: Tom Burgmeier (3-0) L: Sammy Stewart (4-2) | Third | 14 out |
| Wednesday, August 15 |
| » Lost to Athletics (58-63), 6-1 | Memorial Stadium (32-28) | 62-57 | Lost 2 |
| » W: Curt Young (6-1) L: Dennis Martinez (4-7) | Third | 15 out |
| Thursday, August 16 |
| » Lost to Athletics (59-63), 8-1 | Memorial Stadium (32-29) | 62-58 | Lost 3 |
| » W: Lary Sorensen (5-11) L: Storm Davis (12-6) | Fourth | 16 out |
| Friday, August 17 |
| » Defeated Angels (61-60), 6-5 | Memorial Stadium (33-29) | 63-58 | |
| » W: Scott McGregor (14-11) L: Jim Slaton (4-6) S: Sammy Stewart (7) | Third | 16 out |
| Saturday, August 18 |
| » Defeated Angels (61-61), 1-0 | Memorial Stadium (34-29) | 64-58 | Won 2 |
| » W: Mike Boddicker (15-8) L: Mike Witt (11-10) | Third | 16 out |
| Sunday, August 19 |
| » Defeated Angels (61-62), 10-4 | Memorial Stadium (35-29) | 65-58 | Won 3 |
| » W: Mike Flanagan (10-11) L: Bruce Kison (3-2) | Third | 15 out |
| Monday, August 20 |
| » Defeated Mariners (56-70), 5-4 | Memorial Stadium (36-29) | 66-58 | Won 4 |
| » W: Dennis Martinez (5-7) L: Jim Beattie (9-14) S: Sammy Stewart (8) | Third | 15 out |
| Tuesday, August 21 |
| » Lost to Mariners (57-70), 4-3 | Memorial Stadium (36-30) | 66-59 | |
| » W: Salome Barojas (9-4) L: Storm Davis (12-7) S: Edwin Nunez (3) | Third | 16 out |
| Wednesday, August 22 |
| » Defeated Mariners (57-71), 4-0 | Memorial Stadium (37-30) | 67-59 | |
| » W: Scott McGregor (15-11) L: Mike Moore (5-13) | Third | 16 out |
| Friday, August 24 |
| » Defeated Athletics (60-69), 4-2 | Oakland-Alameda County Stadium (2-2) | 68-59 | Won 2 |
| » W: Mike Boddicker (16-8) L: Steve McCatty (7-11) | Third | 15 out |
| Saturday, August 25 |
| » Defeated Athletics (60-70), 4-2 | Oakland-Alameda County Stadium (3-2) | 69-59 | Won 3 |
| » W: Mike Flanagan (11-11) L: Ray Burris (11-7) S: Sammy Stewart (9) | Third | 15 out |
| Sunday, August 26 |
| » Defeated Athletics (60-71), 13-6 | Oakland-Alameda County Stadium (4-2) | 70-59 | Won 4 |
| » W: Tom Underwood (1-0) L: Curt Young (6-3) S: Sammy Stewart (10) | Third | 15 out |
| Monday, August 27 |
| » Defeated Angels (63-67), 7-6 | Anaheim Stadium (3-1) | 71-59 | Won 5 |
| » W: Sammy Stewart (5-2) L: Luis Sanchez (8-6) | Third | 14½ out |
| Tuesday, August 28 |
| » Lost to Angels (64-67), 4-2 | Anaheim Stadium (3-2) | 71-60 | |
| » W: Jim Slaton (6-6) L: Scott McGregor (15-12) S: Don Aase (5) | Third | 15½ out |
| Wednesday, August 29 |
| » Lost to Angels (65-67), 7-5 | Anaheim Stadium (3-3) | 71-61 | Lost 2 |
| » W: Doug Corbett (4-1) L: Mike Boddicker (16-9) | Third | 15½ out |
| Friday, August 31 |
| » Defeated Mariners (59-76), 11-7 | Kingdome (4-0) | 72-61 | |
| » W: Sammy Stewart (6-2) L: Paul Mirabella (1-5) S: Tippy Martinez (17) | Third | 14 out |
| Saturday, September 1 |
| » Lost to Mariners (60-76), 10-9 | Kingdome (4-1) | 72-62 | |
| » W: Ed Vande Berg (8-12) L: Tippy Martinez (4-9) S: Edwin Nunez (5) | Third | 14 out |
| Sunday, September 2 |
| » Defeated Mariners (60-77), 4-3 | Kingdome (5-1) | 73-62 | |
| » W: Bill Swaggerty (3-1) L: Mike Moore (5-14) S: Tom Underwood (1) | Third | 14 out |
| Monday, September 3 |
| » Defeated Tigers (88-50), 7-4 | Tiger Stadium (3-1) | 74-62 | Won 2 |
| » W: Sammy Stewart (7-2) L: Jack Morris (17-10) | Third | 13 out |
| Tuesday, September 4 |
| » Defeated Tigers (88-51), 4-1 | Tiger Stadium (4-1) | 75-62 | Won 3 |
| » W: Mike Boddicker (17-9) L: Dave Rozema (7-6) S: Sammy Stewart (11) | Third | 12 out |
| » Major-league debuts: Roger Mason and Nelson Simmons (Tigers) |
| Wednesday, September 5 |
| » Lost to Tigers (89-51), 1-0 | Tiger Stadium (4-2) | 75-63 | |
| » W: Juan Berenguer (8-9) L: Mike Flanagan (11-12) S: Willie Hernandez (28) | Third | 13 out |
| » Major-league debuts: Vic Rodriguez (Orioles) |
| Friday, September 7 |
| » Lost to Brewers (58-82), 10-8 | Memorial Stadium (37-31) | 75-64 | Lost 2 |
| » W: Tom Tellmann (6-3) L: Sammy Stewart (7-3) S: Ray Searage (3) | Third | 14 out |
| Saturday, September 8 |
| » Defeated Brewers (58-83), 5-3 | Memorial Stadium (38-31) | 76-64 | |
| » W: Storm Davis (13-7) L: Jack Lazorko (0-1) S: Sammy Stewart (12) | Third | 14 out |
| Sunday, September 9 |
| » Defeated Brewers (58-84), 4-0 | Memorial Stadium (39-31) | 77-64 | Won 2 |
| » W: Mike Boddicker (18-9) L: Bob Gibson (0-3) | Third | 14 out |
| Monday, September 10 |
| » Defeated Tigers (92-52), 3-1 | Memorial Stadium (40-31) | 78-64 | Won 3 |
| » W: Mike Flanagan (12-12) L: Juan Berenguer (8-10) | Third | 13 out |
| » Major-league debuts: Scott Earl (Tigers) |
| Tuesday, September 11 |
| » Lost to Tigers (93-52), 9-2 | Memorial Stadium (40-32) | 78-65 | |
| » W: Dan Petry (17-8) L: Bill Swaggerty (3-2) | Third | 14 out |
| Wednesday, September 12 |
| » Defeated Tigers (93-53), 3-1 | Memorial Stadium (41-32) | 79-65 | |
| » W: Dennis Martinez (6-7) L: Roger Mason (0-1) | Third | 13 out |
| » Major-league debuts: Randy O'Neal (Tigers) |
| Thursday, September 13 |
| » Major-league debuts: John Christensen (Mets) |
| Friday, September 14 |
| » Lost to Brewers (61-85), 4-2 | County Stadium (2-3) | 79-66 | |
| » W: Tom Candiotti (2-1) L: Mike Boddicker (18-10) S: Ray Searage (5) | Third | 13 out |
| Saturday, September 15 |
| » Lost to Brewers (62-85), 7-0 | County Stadium (2-4) | 79-67 | Lost 2 |
| » W: Bob Gibson (1-3) L: Mike Flanagan (12-13) | Third | 14 out |
| Sunday, September 16 |
| » Defeated Brewers (62-86), 11-8 | County Stadium (3-4) | 80-67 | |
| » W: Storm Davis (14-7) L: Don Sutton (13-12) | Third | 14 out |
| Monday, September 17 |
| » Lost to Yankees (80-69), 12-7 | Yankee Stadium (2-2) | 80-68 | |
| » W: Jay Howell (9-4) L: John Pacella (0-1) | Third | 15 out |
| Tuesday, September 18 |
| » Lost to Yankees (81-69), 10-2 | Yankee Stadium (2-3) | 80-69 | Lost 2 |
| » W: Ray Fontenot (8-8) L: Dennis Martinez (6-8) | Fourth | 16 out |
| » Major-league debuts: Larry Sheets (Orioles) |
| Wednesday, September 19 |
| » Lost to Yankees (82-69), 6-5 | Yankee Stadium (2-4) | 80-70 | Lost 3 |
| » W: Joe Cowley (9-1) L: Mike Boddicker (18-11) S: Dave Righetti (27) | Fourth | 17 out |
| Thursday, September 20 |
| » Defeated Red Sox (80-72), 15-1 | Memorial Stadium (42-32) | 81-70 | |
| » W: Mike Flanagan (13-13) L: Al Nipper (10-6) | Fourth | 16½ out |
| Friday, September 21 |
| » Lost to Red Sox (81-72), 8-0 | Memorial Stadium (42-33) | 81-71 | |
| » W: Oil Can Boyd (12-10) L |