| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Wednesday, April 4 |
| » Defeated Blue Jays (0-1), 3-2 | Kingdome (1-0) | 1-0 | |
| » W: Mike Stanton (1-0) L: Dennis Lamp (0-1) | Second | ½ out |
| Thursday, April 5 |
| » Lost to Blue Jays (1-1), 13-5 | Kingdome (1-1) | 1-1 | |
| » W: Luis Leal (1-0) L: Jim Beattie (0-1) | Fourth | 1 out |
| Friday, April 6 |
| » Defeated Brewers (0-3), 6-3 | Kingdome (2-1) | 2-1 | |
| » W: Matt Young (1-0) L: Moose Haas (0-1) S: Ed Vande Berg (1) | Second | 1 out |
| Saturday, April 7 |
| » Defeated Brewers (0-4), 3-2 | Kingdome (3-1) | 3-1 | Won 2 |
| » W: Mark Langston (1-0) L: Tom Tellmann (0-1) S: Ed Vande Berg (2) | First | -- |
| » Major-league debuts: Mark Langston (Mariners) |
| Sunday, April 8 |
| » Defeated Brewers (0-5), 5-4 | Kingdome (4-1) | 4-1 | Won 3 |
| » W: Mike Moore (1-0) L: Don Sutton (0-1) S: Dave Beard (1) | First | -- |
| Tuesday, April 10 |
| » Defeated Red Sox (3-4), 5-1 | Kingdome (5-1) | 5-1 | Won 4 |
| » W: Jim Beattie (1-1) L: Bob Ojeda (0-1) S: Mike Stanton (1) | First | -- |
| Wednesday, April 11 |
| » Defeated Red Sox (3-5), 5-4 | Kingdome (6-1) | 6-1 | Won 5 |
| » W: Matt Young (2-0) L: Dennis Eckersley (0-1) S: Roy Thomas (1) | First | -- |
| » Major-league debuts: Alvin Davis (Mariners) |
| Friday, April 13 |
| » Lost to Twins (5-3), 4-3 | Hubert H. Humphrey Metrodome (0-1) | 6-2 | |
| » W: Ron Davis (1-0) L: Mike Stanton (1-1) | First | -- |
| Saturday, April 14 |
| » Lost to Twins (6-3), 4-3 | Hubert H. Humphrey Metrodome (0-2) | 6-3 | Lost 2 |
| » W: Ron Davis (2-0) L: Bob Stoddard (0-1) | Second | ½ out |
| Sunday, April 15 |
| » Defeated Twins (6-4), 5-4 | Hubert H. Humphrey Metrodome (1-2) | 7-3 | |
| » W: Roy Thomas (1-0) L: Mike Walters (0-1) S: Dave Beard (2) | First | -- |
| Monday, April 16 |
| » Lost to Athletics (8-4), 9-6 | Kingdome (6-2) | 7-4 | |
| » W: Mike Warren (1-2) L: Matt Young (2-1) S: Bill Caudill (3) | Second | ½ out |
| Tuesday, April 17 |
| » Lost to Athletics (9-4), 6-2 | Kingdome (6-3) | 7-5 | Lost 2 |
| » W: Steve McCatty (2-0) L: Mike Moore (1-1) S: Chris Codiroli (1) | Second | 1½ out |
| Wednesday, April 18 |
| » Defeated Athletics (9-5), 5-4 | Kingdome (7-3) | 8-5 | |
| » W: Paul Mirabella (1-0) L: Keith Atherton (0-1) | Second | ½ out |
| Friday, April 20 |
| » Defeated Brewers (4-9), 5-0 | County Stadium (1-0) | 9-5 | Won 2 |
| » W: Jim Beattie (2-1) L: Don Sutton (1-2) | First | -- |
| Saturday, April 21 |
| » Lost to Brewers (5-9), 6-2 | County Stadium (1-1) | 9-6 | |
| » W: Mike Caldwell (3-1) L: Matt Young (2-2) | Second | ½ out |
| Monday, April 23 |
| » Lost to Blue Jays (10-7), 8-5 | Exhibition Stadium (0-1) | 9-7 | Lost 2 |
| » W: Dave Stieb (3-0) L: Mark Langston (1-1) S: Roy Lee Jackson (2) | Second | ½ out |
| Tuesday, April 24 |
| » Defeated Blue Jays (10-8), 4-2 | Exhibition Stadium (1-1) | 10-7 | |
| » W: Dave Beard (1-0) L: Jim Clancy (1-2) | First | -- |
| Wednesday, April 25 |
| » Lost to Red Sox (7-11), 2-1 | Fenway Park (0-1) | 10-8 | |
| » W: Bruce Hurst (3-2) L: Jim Beattie (2-2) | Second | 1½ out |
| Thursday, April 26 |
| » Defeated Red Sox (7-12), 6-5 | Fenway Park (1-1) | 11-8 | |
| » W: Ed Vande Berg (1-0) L: Bob Stanley (1-2) S: Paul Mirabella (1) | First | -- |
| Friday, April 27 |
| » Lost to Angels (13-10), 9-3 | Anaheim Stadium (0-1) | 11-9 | |
| » W: Ron Romanick (3-1) L: Bob Stoddard (0-2) | Third | ½ out |
| Saturday, April 28 |
| » Lost to Angels (14-10), 10-1 | Anaheim Stadium (0-2) | 11-10 | Lost 2 |
| » W: Geoff Zahn (3-1) L: Mark Langston (1-2) | Third | 1½ out |
| Sunday, April 29 |
| » Defeated Angels (14-11), 9-6 | Anaheim Stadium (1-2) | 12-10 | |
| » W: Roy Thomas (2-0) L: Frank LaCorte (0-1) | Third | 1 out |
| Monday, April 30 |
| » Lost to Angels (15-11), 8-1 | Anaheim Stadium (1-3) | 12-11 | |
| » W: Mike Witt (3-1) L: Paul Mirabella (1-1) | Third | 1½ out |
| Tuesday, May 1 |
| » Defeated Twins (11-14), 11-8 | Kingdome (8-3) | 13-11 | |
| » W: Dave Beard (2-0) L: Mike Walters (0-2) | Third | 1½ out |
| Wednesday, May 2 |
| » Lost to Twins (12-14), 8-6 | Kingdome (8-4) | 13-12 | |
| » W: Larry Pashnick (1-1) L: Ed Vande Berg (1-1) S: Ron Davis (4) | Third | 1½ out |
| Thursday, May 3 |
| » Defeated Twins (12-15), 6-2 | Kingdome (9-4) | 14-12 | |
| » W: Mark Langston (2-2) L: Mike Smithson (3-3) S: Dave Beard (3) | Third | 1 out |
| Friday, May 4 |
| » Lost to Angels (17-12), 4-1 | Kingdome (9-5) | 14-13 | |
| » W: Geoff Zahn (4-1) L: Mike Moore (1-2) | Third | 2 out |
| Saturday, May 5 |
| » Lost to Angels (18-12), 3-1 | Kingdome (9-6) | 14-14 | Lost 2 |
| » W: Mike Witt (4-1) L: Jim Beattie (2-3) | Third | 3 out |
| Sunday, May 6 |
| » Defeated Angels (18-13), 3-1 | Kingdome (10-6) | 15-14 | |
| » W: Ed Vande Berg (2-1) L: Tommy John (2-3) S: Dave Beard (4) | Second | 2 out |
| Monday, May 7 |
| » Lost to Athletics (16-14), 6-5 | Oakland-Alameda County Stadium (0-1) | 15-15 | |
| » W: Bill Caudill (4-0) L: Roy Thomas (2-1) | Fourth | 2 out |
| Tuesday, May 8 |
| » Lost to Athletics (17-14), 3-2 | Oakland-Alameda County Stadium (0-2) | 15-16 | Lost 2 |
| » W: Bill Caudill (5-0) L: Dave Beard (2-1) | Fourth | 2 out |
| Wednesday, May 9 |
| » Defeated Athletics (17-15), 4-1 | Oakland-Alameda County Stadium (1-2) | 16-16 | |
| » W: Mike Stanton (2-1) L: Keith Atherton (1-2) | Fourth | 1½ out |
| Friday, May 11 |
| » Defeated Yankees (12-18), 4-3 | Yankee Stadium (1-0) | 17-16 | Won 2 |
| » W: Roy Thomas (3-1) L: Clay Christiansen (0-1) | Second | ½ out |
| Saturday, May 12 |
| » Defeated Yankees (12-19), 5-0 | Yankee Stadium (2-0) | 18-16 | Won 3 |
| » W: Jim Beattie (3-3) L: Shane Rawley (1-3) | Second | ½ out |
| Sunday, May 13 |
| » Lost to Yankees (13-19), 7-0 | Yankee Stadium (2-1) | 18-17 | |
| » W: Bob Shirley (1-0) L: Mark Langston (2-3) | Second | ½ out |
| Monday, May 14 |
| » Lost to Tigers (27-5), 7-5 | Tiger Stadium (0-1) | 18-18 | Lost 2 |
| » W: Aurelio Lopez (4-0) L: Ed Vande Berg (2-2) | Fourth | 1 out |
| Tuesday, May 15 |
| » Lost to Tigers (28-5), 6-4 | Tiger Stadium (0-2) | 18-19 | Lost 3 |
| » W: Jack Morris (7-1) L: Roy Thomas (3-2) S: Willie Hernandez (5) | Fourth | 1½ out |
| Wednesday, May 16 |
| » Lost to Tigers (29-5), 10-1 | Tiger Stadium (0-3) | 18-20 | Lost 4 |
| » W: Milt Wilcox (5-0) L: Matt Young (2-3) | Fourth | 1½ out |
| Friday, May 18 |
| » Lost to Orioles (21-17), 4-1 | Memorial Stadium (0-1) | 18-21 | Lost 5 |
| » W: Storm Davis (4-0) L: Jim Beattie (3-4) | Fourth | 2½ out |
| Saturday, May 19 |
| » Defeated Orioles (21-18), 6-5 | Memorial Stadium (1-1) | 19-21 | |
| » W: Ed Vande Berg (3-2) L: Tippy Martinez (1-4) | Third | 2½ out |
| Sunday, May 20 |
| » Lost to Orioles (22-18), 5-1 | Memorial Stadium (1-2) | 19-22 | |
| » W: Mike Flanagan (3-3) L: Mike Moore (1-3) S: Tippy Martinez (6) | Fourth | 3½ out |
| Tuesday, May 22 |
| » Defeated Yankees (16-23), 5-3 | Kingdome (11-6) | 20-22 | |
| » W: Matt Young (3-3) L: Jose Rijo (1-4) S: Ed Vande Berg (3) | Third | 2½ out |
| Wednesday, May 23 |
| » Lost to Yankees (17-23), 3-0 | Kingdome (11-7) | 20-23 | |
| » W: Dennis Rasmussen (1-0) L: Jim Beattie (3-5) S: Dave Righetti (5) | Third | 2½ out |
| Thursday, May 24 |
| » Lost to Yankees (18-23), 2-0 | Kingdome (11-8) | 20-24 | Lost 2 |
| » W: Phil Niekro (7-2) L: Mark Langston (2-4) S: Dave Righetti (6) | Fourth | 2½ out |
| Friday, May 25 |
| » Defeated Tigers (35-6), 7-3 | Kingdome (12-8) | 21-24 | |
| » W: Ed Vande Berg (4-2) L: Milt Wilcox (6-1) S: Paul Mirabella (2) | Third | 2½ out |
| Saturday, May 26 |
| » Defeated Tigers (35-7), 9-5 | Kingdome (13-8) | 22-24 | Won 2 |
| » W: Mike Moore (2-3) L: Juan Berenguer (3-3) | Third | 1½ out |
| Sunday, May 27 |
| » Defeated Tigers (35-8), 6-1 | Kingdome (14-8) | 23-24 | Won 3 |
| » W: Matt Young (4-3) L: Dan Petry (7-2) | Second | ½ out |
| Monday, May 28 |
| » Lost to Orioles (26-21), 7-4 | Kingdome (14-9) | 23-25 | |
| » W: Storm Davis (5-1) L: Jim Beattie (3-6) | Third | 1½ out |
| Tuesday, May 29 |
| » Lost to Orioles (27-21), 3-2 | Kingdome (14-10) | 23-26 | Lost 2 |
| » W: Tippy Martinez (2-4) L: Paul Mirabella (1-2) | Third | 2½ out |
| Wednesday, May 30 |
| » Lost to Orioles (28-21), 8-2 | Kingdome (14-11) | 23-27 | Lost 3 |
| » W: Mike Boddicker (6-4) L: Ed Vande Berg (4-3) | Third | 2½ out |
| Friday, June 1 |
| » Defeated Rangers (20-30), 5-3 | Arlington Stadium (1-0) | 24-27 | |
| » W: Dave Beard (3-1) L: Dave Tobik (1-4) | Third | 2½ out |
| Saturday, June 2 |
| » Defeated Rangers (20-31), 10-7 | Arlington Stadium (2-0) | 25-27 | Won 2 |
| » W: Bob Stoddard (1-2) L: Dave Schmidt (0-3) S: Mike Stanton (2) | Second | 2½ out |
| Sunday, June 3 |
| » Defeated Rangers (20-32), 10-4 | Arlington Stadium (3-0) | 26-27 | Won 3 |
| » W: Jim Beattie (4-6) L: Frank Tanana (5-6) S: Dave Beard (5) | Second | 2½ out |
| Monday, June 4 |
| » Defeated Royals (23-27), 7-1 | Royals Stadium (1-0) | 27-27 | Won 4 |
| » W: Mark Langston (3-4) L: Bret Saberhagen (2-5) | Second | 1½ out |
| Tuesday, June 5 |
| » Lost to Royals (24-27), 4-3 | Royals Stadium (1-1) | 27-28 | |
| » W: Mark Gubicza (3-4) L: Ed Vande Berg (4-4) S: Dan Quisenberry (13) | Second | 2½ out |
| Wednesday, June 6 |
| » Lost to Royals (25-27), 5-2 | Royals Stadium (1-2) | 27-29 | Lost 2 |
| » W: Charlie Leibrandt (2-0) L: Mike Moore (2-4) S: Dan Quisenberry (14) | Second | 2½ out |
| Thursday, June 7 |
| » Lost to Royals (26-27), 9-8 | Royals Stadium (1-3) | 27-30 | Lost 3 |
| » W: Danny Jackson (1-5) L: Dave Beard (3-2) S: Dan Quisenberry (15) | Fifth | 2½ out |
| Friday, June 8 |
| » Lost to Indians (19-33), 4-3 | Cleveland Stadium (0-1) | 27-31 | Lost 4 |
| » W: Steve Comer (1-0) L: Jim Beattie (4-7) S: Ernie Camacho (8) | Fifth | 3 out |
| Saturday, June 9 |
| » Lost to Indians (20-33), 8-7 | Cleveland Stadium (0-2) | 27-32 | Lost 5 |
| » W: George Frazier (3-2) L: Mark Langston (3-5) S: Steve Farr (1) | Fifth | 4 out |
| Sunday, June 10 |
| » Lost to Indians (21-33), 3-1 | Cleveland Stadium (0-3) | 27-33 | Lost 6 |
| » W: Neal Heaton (4-5) L: Ed Vande Berg (4-5) S: Mike Jeffcoat (1) | Fifth | 4½ out |
| » Defeated Indians (21-34), 4-3 | Cleveland Stadium (1-3) | 28-33 | |
| » W: Mark Langston (4-5) L: Ernie Camacho (1-6) S: Mike Stanton (3) | Fifth | 4½ out |
| Tuesday, June 12 |
| » Defeated Royals (26-30), 3-2 | Kingdome (15-11) | 29-33 | Won 2 |
| » W: Mike Moore (3-4) L: Bret Saberhagen (2-6) | Third | 4½ out |
| Wednesday, June 13 |
| » Lost to Royals (27-30), 6-4 | Kingdome (15-12) | 29-34 | |
| » W: Larry Gura (7-2) L: Matt Young (4-4) S: Dan Quisenberry (16) | Fourth | 4½ out |
| Thursday, June 14 |
| » Defeated Royals (27-31), 4-1 | Kingdome (16-12) | 30-34 | |
| » W: Jim Beattie (5-7) L: Bud Black (6-5) S: Mike Stanton (4) | Third | 4½ out |
| Friday, June 15 |
| » Defeated Rangers (27-37), 4-3 | Kingdome (17-12) | 31-34 | Won 2 |
| » W: Edwin Nunez (1-0) L: Joey McLaughlin (0-1) | Third | 4½ out |
| Saturday, June 16 |
| » Lost to Rangers (28-37), 5-1 | Kingdome (17-13) | 31-35 | |
| » W: Mike Mason (4-4) L: Ed Vande Berg (4-6) | Fourth | 5½ out |
| Sunday, June 17 |
| » Defeated Rangers (28-38), 5-2 | Kingdome (18-13) | 32-35 | |
| » W: Mike Stanton (3-1) L: Odell Jones (1-2) | Fourth | 4½ out |
| Monday, June 18 |
| » Lost to White Sox (32-33), 8-4 | Kingdome (18-14) | 32-36 | |
| » W: Richard Dotson (9-3) L: Matt Young (4-5) | Third | 4½ out |
| Tuesday, June 19 |
| » Defeated White Sox (32-34), 8-2 | Kingdome (19-14) | 33-36 | |
| » W: Jim Beattie (6-7) L: Britt Burns (2-8) | Third | 3½ out |
| Wednesday, June 20 |
| » Lost to White Sox (33-34), 5-4 | Kingdome (19-15) | 33-37 | |
| » W: La Marr Hoyt (7-6) L: Mark Langston (4-6) S: Juan Agosto (2) | Third | 3½ out |
| Friday, June 22 |
| » Lost to Indians (26-39), 13-3 | Kingdome (19-16) | 33-38 | Lost 2 |
| » W: Mike Jeffcoat (3-1) L: Ed Vande Berg (4-7) | Fourth | 4½ out |
| Saturday, June 23 |
| » Lost to Indians (27-39), 11-4 | Kingdome (19-17) | 33-39 | Lost 3 |
| » W: Roy Smith (1-0) L: Mike Moore (3-5) | Fifth | 4½ out |
| » Major-league debuts: Roy Smith (Indians) |
| Sunday, June 24 |
| » Lost to Indians (28-39), 5-0 | Kingdome (19-18) | 33-40 | Lost 4 |
| » W: Bert Blyleven (6-3) L: Bob Stoddard (1-3) | Fifth | 4½ out |
| » Major-league debuts: Jim Presley (Mariners) |
| Monday, June 25 |
| » Defeated White Sox (34-37), 6-1 | Comiskey Park I (1-0) | 34-40 | |
| » W: Jim Beattie (7-7) L: Britt Burns (2-9) | Fifth | 3½ out |
| Tuesday, June 26 |
| » Defeated White Sox (34-38), 5-0 | Comiskey Park I (2-0) | 35-40 | Won 2 |
| » W: Mark Langston (5-6) L: La Marr Hoyt (7-7) | Fifth | 3½ out |
| Wednesday, June 27 |
| » Lost to White Sox (35-38), 9-7 | Comiskey Park I (2-1) | 35-41 | |
| » W: Salome Barojas (3-2) L: Edwin Nunez (1-1) | Fifth | 4½ out |
| Thursday, June 28 |
| » Lost to Red Sox (36-38), 9-6 | Fenway Park (1-2) | 35-42 | Lost 2 |
| » W: Bob Stanley (3-6) L: Paul Mirabella (1-3) | Fifth | 5½ out |
| Friday, June 29 |
| » Defeated Red Sox (36-39), 5-3 | Fenway Park (2-2) | 36-42 | |
| » W: Ed Vande Berg (5-7) L: Bob Ojeda (6-6) S: Salome Barojas (2) | Fifth | 4½ out |
| Saturday, June 30 |
| » Defeated Red Sox (36-40), 2-1 | Fenway Park (3-2) | 37-42 | Won 2 |
| » W: Jim Beattie (8-7) L: Oil Can Boyd (2-6) | Fourth | 4½ out |
| Sunday, July 1 |
| » Defeated Red Sox (36-41), 1-0 | Fenway Park (4-2) | 38-42 | Won 3 |
| » W: Mark Langston (6-6) L: Al Nipper (1-3) | Fourth | 4½ out |
| Monday, July 2 |
| » Lost to Brewers (35-43), 3-2 | County Stadium (1-2) | 38-43 | |
| » W: Don Sutton (6-7) L: Mike Moore (3-6) S: Rollie Fingers (16) | Sixth | 6 out |
| » Lost to Brewers (36-43), 6-4 | County Stadium (1-3) | 38-44 | Lost 2 |
| » W: Tom Tellmann (3-1) L: Salome Barojas (3-3) S: Rollie Fingers (17) | Sixth | 6 out |
| Tuesday, July 3 |
| » Lost to Brewers (37-43), 11-6 | County Stadium (1-4) | 38-45 | Lost 3 |
| » W: Pete Ladd (3-4) L: Matt Young (4-6) | Sixth | 6 out |
| Wednesday, July 4 |
| » Lost to Brewers (38-43), 4-2 | County Stadium (1-5) | 38-46 | Lost 4 |
| » W: Moose Haas (6-6) L: Ed Vande Berg (5-8) | Fifth | 6 out |
| Thursday, July 5 |
| » Lost to Blue Jays (49-32), 10-8 | Exhibition Stadium (1-2) | 38-47 | Lost 5 |
| » W: Doyle Alexander (7-4) L: Jim Beattie (8-8) S: Roy Lee Jackson (5) | Fifth | 6 out |
| Friday, July 6 |
| » Lost to Blue Jays (50-32), 9-2 | Exhibition Stadium (1-3) | 38-48 | Lost 6 |
| » W: Luis Leal (9-2) L: Mark Langston (6-7) | Fifth | 6 out |
| Saturday, July 7 |
| » Defeated Blue Jays (50-33), 8-4 | Exhibition Stadium (2-3) | 39-48 | |
| » W: Mike Moore (4-6) L: Jim Clancy (6-10) S: Mike Stanton (5) | Sixth | 6 out |
| Sunday, July 8 |
| » Defeated Blue Jays (50-34), 7-1 | Exhibition Stadium (3-3) | 40-48 | Won 2 |
| » W: Jim Beattie (9-8) L: Jim Gott (5-3) S: Ed Vande Berg (4) | Sixth | 6 out |
| Thursday, July 12 |
| » Defeated Red Sox (41-44), 3-2 | Kingdome (20-18) | 41-48 | Won 3 |
| » W: Mark Langston (7-7) L: Bob Ojeda (6-7) S: Paul Mirabella (3) | Sixth | 5 out |
| Friday, July 13 |
| » Lost to Red Sox (42-44), 9-5 | Kingdome (20-19) | 41-49 | |
| » W: Oil Can Boyd (4-6) L: Mike Moore (4-7) | Sixth | 5 out |
| Saturday, July 14 |
| » Defeated Red Sox (42-45), 5-4 | Kingdome (21-19) | 42-49 | |
| » W: Ed Vande Berg (6-8) L: Roger Clemens (3-4) S: Mike Stanton (6) | Fifth | 5 out |
| Sunday, July 15 |
| » Lost to Red Sox (43-45), 11-3 | Kingdome (21-20) | 42-50 | |
| » W: Al Nipper (3-3) L: Jim Beattie (9-9) | Fifth | 6 out |
| Monday, July 16 |
| » Defeated Brewers (40-51), 11-2 | Kingdome (22-20) | 43-50 | |
| » W: Salome Barojas (4-3) L: Tom Candiotti (0-1) | Fifth | 6 out |
| Tuesday, July 17 |
| » Defeated Brewers (40-52), 3-1 | Kingdome (23-20) | 44-50 | Won 2 |
| » W: Mark Langston (8-7) L: Jaime Cocanower (7-9) S: Mike Stanton (7) | Fourth | 6 out |
| Wednesday, July 18 |
| » Lost to Brewers (41-52), 5-2 | Kingdome (23-21) | 44-51 | |
| » W: Don Sutton (8-8) L: Mike Moore (4-8) S: Rollie Fingers (20) | Fifth | 6 out |
| Thursday, July 19 |
| » Lost to Blue Jays (55-37), 8-1 | Kingdome (23-22) | 44-52 | Lost 2 |
| » W: Dave Stieb (11-3) L: Ed Vande Berg (6-9) | Fifth | 6½ out |
| Friday, July 20 |
| » Lost to Blue Jays (56-37), 12-7 | Kingdome (23-23) | 44-53 | Lost 3 |
| » W: Jim Acker (3-5) L: Paul Mirabella (1-4) | Fifth | 6½ out |
| Saturday, July 21 |
| » Defeated Blue Jays (56-38), 9-3 | Kingdome (24-23) | 45-53 | |
| » W: Salome Barojas (5-3) L: Dennis Lamp (4-5) | Fifth | 5½ out |
| Sunday, July 22 |
| » Lost to Blue Jays (57-38), 5-3 | Kingdome (24-24) | 45-54 | |
| » W: Doyle Alexander (8-4) L: Mark Langston (8-8) S: Roy Lee Jackson (8) | Fifth | 5½ out |
| Monday, July 23 |
| » Lost to Angels (50-47), 7-1 | Anaheim Stadium (1-4) | 45-55 | Lost 2 |
| » W: Mike Witt (11-7) L: Mike Moore (4-9) | Fifth | 6½ out |
| Tuesday, July 24 |
| » Defeated Angels (50-48), 4-3 | Anaheim Stadium (2-4) | 46-55 | |
| » W: Ed Vande Berg (7-9) L: Geoff Zahn (9-8) S: Mike Stanton (8) | Sixth | 5½ out |
| Wednesday, July 25 |
| » Lost to Angels (51-48), 1-0 | Anaheim Stadium (2-5) | 46-56 | |
| » W: Luis Sanchez (7-2) L: Jim Beattie (9-10) | Sixth | 6½ out |
| Friday, July 27 |
| » Defeated Athletics (48-55), 12-2 | Kingdome (25-24) | 47-56 | |
| » W: Salome Barojas (6-3) L: Bill Krueger (7-7) | Sixth | 5½ out |
| Saturday, July 28 |
| » Defeated Athletics (48-56), 2-1 | Kingdome (26-24) | 48-56 | Won 2 |
| » W: Mark Langston (9-8) L: Ray Burris (9-6) S: Ed Vande Berg (5) | Fifth | 5 out |
| Sunday, July 29 |
| » Defeated Athletics (48-57), 4-1 | Kingdome (27-24) | 49-56 | Won 3 |
| » W: Mike Moore (5-9) L: Steve McCatty (7-8) | Fifth | 5 out |
| Monday, July 30 |
| » Lost to Twins (53-49), 9-5 | Hubert H. Humphrey Metrodome (1-3) | 49-57 | |
| » W: Pete Filson (6-2) L: Jim Beattie (9-11) | Fifth | 6 out |
| Tuesday, July 31 |
| » Lost to Twins (54-49), 9-2 | Hubert H. Humphrey Metrodome (1-4) | 49-58 | Lost 2 |
| » W: Ken Schrom (3-5) L: Ed Vande Berg (7-10) | Fifth | 7 out |
| Wednesday, August 1 |
| » Defeated Twins (54-50), 5-1 | Hubert H. Humphrey Metrodome (2-4) | 50-58 | |
| » W: Salome Barojas (7-3) L: Mike Smithson (11-9) | Fifth | 6 out |
| Friday, August 3 |
| » Lost to Athletics (49-60), 5-3 | Oakland-Alameda County Stadium (1-3) | 50-59 | |
| » W: Ray Burris (10-6) L: Mike Moore (5-10) S: Bill Caudill (22) | Fifth | 7 out |
| » Lost to Athletics (50-60), 11-7 | Oakland-Alameda County Stadium (1-4) | 50-60 | Lost 2 |
| » W: Chuck Rainey (6-8) L: Mark Langston (9-9) S: Keith Atherton (1) | Fifth | 7 out |
| Saturday, August 4 |
| » Lost to Athletics (51-60), 4-2 | Oakland-Alameda County Stadium (1-5) | 50-61 | Lost 3 |
| » W: Curt Young (4-1) L: Jim Beattie (9-12) S: Bill Caudill (23) | Sixth | 7½ out |
| Sunday, August 5 |
| » Lost to Athletics (52-60), 5-4 | Oakland-Alameda County Stadium (1-6) | 50-62 | Lost 4 |
| » W: Lary Sorensen (4-11) L: Ed Vande Berg (7-11) S: Bill Caudill (24) | Sixth | 8 out |
| Monday, August 6 |
| » Lost to Angels (57-53), 8-4 | Kingdome (27-25) | 50-63 | Lost 5 |
| » W: Tommy John (7-9) L: Salome Barojas (7-4) | Sixth | 9 out |
| Tuesday, August 7 |
| » Lost to Angels (58-53), 7-6 | Kingdome (27-26) | 50-64 | Lost 6 |
| » W: Don Aase (1-1) L: Mike Stanton (3-2) | Sixth | 10 out |
| Wednesday, August 8 |
| » Defeated Angels (58-54), 7-2 | Kingdome (28-26) | 51-64 | |
| » W: Mark Langston (10-9) L: Mike Witt (11-9) S: Edwin Nunez (1) | Sixth | 9 out |
| Thursday, August 9 |
| » Defeated Twins (58-54), 6-5 | Kingdome (29-26) | 52-64 | Won 2 |
| » W: Mike Stanton (4-2) L: Ron Davis (4-8) | Sixth | 8 out |
| Friday, August 10 |
| » Lost to Twins (59-54), 13-7 | Kingdome (29-27) | 52-65 | |
| » W: Rick Lysander (2-1) L: Ed Vande Berg (7-12) | Sixth | 9 out |
| » Major-league debuts: Ivan Calderon (Mariners) |
| Saturday, August 11 |
| » Defeated Twins (59-55), 5-4 | Kingdome (30-27) | 53-65 | |
| » W: Edwin Nunez (2-1) L: Pete Filson (6-4) | Sixth | 8 out |
| Sunday, August 12 |
| » Lost to Twins (60-55), 3-0 | Kingdome (30-28) | 53-66 | |
| » W: Frank Viola (13-10) L: Mike Moore (5-11) | Sixth | 9 out |
| Tuesday, August 14 |
| » Defeated Yankees (61-57), 2-1 | Yankee Stadium (3-1) | 54-66 | |
| » W: Mark Langston (11-9) L: Dennis Rasmussen (7-4) S: Ed Vande Berg (6) | Sixth | 9½ out |
| Wednesday, August 15 |
| » Lost to Yankees (62-57), 3-2 | Yankee Stadium (3-2) | 54-67 | |
| » W: Joe Cowley (4-1) L: Jim Beattie (9-13) S: Dave Righetti (21) | Fifth | 9½ out |
| Thursday, August 16 |
| » Defeated Yankees (62-58), 5-4 | Yankee Stadium (4-2) | 55-67 | |
| » W: Salome Barojas (8-4) L: Phil Niekro (14-7) S: Edwin Nunez (2) | Sixth | 8½ out |
| Friday, August 17 |
| » Lost to Tigers (80-43), 6-2 | Tiger Stadium (0-4) | 55-68 | |
| » W: Milt Wilcox (13-7) L: Mike Moore (5-12) | Sixth | 9½ out |
| Saturday, August 18 |
| » Lost to Tigers (81-43), 4-3 | Tiger Stadium (0-5) | 55-69 | Lost 2 |
| » W: Juan Berenguer (6-8) L: Dave Geisel (0-1) S: Willie Hernandez (26) | Sixth | 11 out |
| Sunday, August 19 |
| » Defeated Tigers (81-44), 4-1 | Tiger Stadium (1-5) | 56-69 | |
| » W: Mark Langston (12-9) L: Dan Petry (15-6) S: Ed Vande Berg (7) | Sixth | 10 out |
| Monday, August 20 |
| » Lost to Orioles (66-58), 5-4 | Memorial Stadium (1-3) | 56-70 | |
| » W: Dennis Martinez (5-7) L: Jim Beattie (9-14) S: Sammy Stewart (8) | Fifth | 10½ out |
| Tuesday, August 21 |
| » Defeated Orioles (66-59), 4-3 | Memorial Stadium (2-3) | 57-70 | |
| » W: Salome Barojas (9-4) L: Storm Davis (12-7) S: Edwin Nunez (3) | Fifth | 10 out |
| Wednesday, August 22 |
| » Lost to Orioles (67-59), 4-0 | Memorial Stadium (2-4) | 57-71 | |
| » W: Scott McGregor (15-11) L: Mike Moore (5-13) | Fifth | 11½ out |
| Friday, August 24 |
| » Lost to Yankees (67-60), 6-4 | Kingdome (30-29) | 57-72 | Lost 2 |
| » W: Dave Righetti (3-4) L: Mike Stanton (4-3) | Sixth | 11 out |
| Saturday, August 25 |
| » Lost to Yankees (68-60), 14-1 | Kingdome (30-30) | 57-73 | Lost 3 |
| » W: Dennis Rasmussen (8-4) L: Jim Beattie (9-15) | Sixth | 12 out |
| Sunday, August 26 |
| » Lost to Yankees (69-60), 7-2 | Kingdome (30-31) | 57-74 | Lost 4 |
| » W: Phil Niekro (16-7) L: Salome Barojas (9-5) | Seventh | 12 out |
| Tuesday, August 28 |
| » Lost to Tigers (87-45), 5-4 | Kingdome (30-32) | 57-75 | Lost 5 |
| » W: Willie Hernandez (8-2) L: Mike Stanton (4-4) | Seventh | 12½ out |
| Wednesday, August 29 |
| » Defeated Tigers (87-46), 5-1 | Kingdome (31-32) | 58-75 | |
| » W: Mark Langston (13-9) L: Dan Petry (15-8) | Seventh | 11½ out |
| Thursday, August 30 |
| » Defeated Tigers (87-47), 2-1 | Kingdome (32-32) | 59-75 | Won 2 |
| » W: Jim Beattie (10-15) L: Jack Morris (17-9) S: Edwin Nunez (4) | Seventh | 10½ out |
| Friday, August 31 |
| » Lost to Orioles (72-61), 11-7 | Kingdome (32-33) | 59-76 | |
| » W: Sammy Stewart (6-2) L: Paul Mirabella (1-5) S: Tippy Martinez (17) | Seventh | 10½ out |
| Saturday, September 1 |
| » Defeated Orioles (72-62), 10-9 | Kingdome (33-33) | 60-76 | |
| » Manager: Chuck Cottier |
| » W: Ed Vande Berg (8-12) L: Tippy Martinez (4-9) S: Edwin Nunez (5) | Seventh | 9½ out |
| Sunday, September 2 |
| » Lost to Orioles (73-62), 4-3 | Kingdome (33-34) | 60-77 | |
| » W: Bill Swaggerty (3-1) L: Mike Moore (5-14) S: Tom Underwood (1) | Seventh | 9½ out |
| Monday, September 3 |
| » Defeated Rangers (61-75), 7-3 | Arlington Stadium (4-0) | 61-77 | |
| » W: Mark Langston (14-9) L: Frank Tanana (14-13) S: Edwin Nunez (6) | Seventh | 9½ out |
| Tuesday, September 4 |
| » Defeated Rangers (61-76), 6-3 | Arlington Stadium (5-0) | 62-77 | Won 2 |
| » W: Bob Stoddard (2-3) L: Dave Schmidt (6-6) S: Dave Geisel (1) | Sixth | 8½ out |
| Wednesday, September 5 |
| » Defeated Rangers (61-77), 6-5 | Arlington Stadium (6-0) | 63-77 | Won 3 |
| » W: Paul Mirabella (2-5) L: Dave Stewart (5-13) S: Dave Geisel (2) | Fifth | 7½ out |
| Friday, September 7 |
| » Lost to Royals (71-69), 5-4 | Royals Stadium (1-4) | 63-78 | |
| » W: Bret Saberhagen (8-10) L: Matt Young (4-7) S: Dan Quisenberry (39) | Fifth | 8½ out |
| » Major-league debuts: Danny Tartabull and Dave Valle (Mariners) |
| Saturday, September 8 |
| » Lost to Royals (72-69), 5-4 | Royals Stadium (1-5) | 63-79 | Lost 2 |
| » W: Joe Beckwith (8-3) L: Mike Moore (5-15) | Fifth | 9½ out |
| Sunday, September 9 |
| » Lost to Royals (73-69), 6-5 | Royals Stadium (1-6) | 63-80 | Lost 3 |
| » W: Mark Huismann (3-3) L: Edwin Nunez (2-2) | Sixth | 10½ out |
| Monday, September 10 |
| » Defeated Rangers (62-80), 7-3 | Kingdome (34-34) | 64-80 | |
| » W: Jim Beattie (11-15) L: Danny Darwin (8-10) | Fifth | 9½ out |
| Tuesday, September 11 |
| » Defeated Rangers (62-81), 4-3 | Kingdome (35-34) | 65-80 | Won 2 |
| » W: Karl Best (1-0) L: Dickie Noles (3-5) | Sixth | 9½ out |
| Wednesday, September 12 |
| » Lost to Rangers (63-81), 8-1 | Kingdome (35-35) | 65-81 | |
| » W: Mike Mason (9-12) L: Matt Young (4-8) | Fifth | 9½ out |
| » Major-league debuts: Lee Guetterman (Mariners) |
| Thursday, September 13 |
| » Lost to Rangers (64-81), 9-7 | Kingdome (35-36) | 65-82 | Lost 2 |
| » W: Frank Tanana (15-13) L: Mike Moore (5-16) S: Tom Henke (1) | Fifth | 10 out |
| Friday, September 14 |
| » Defeated Royals (74-72), 2-1 | Kingdome (36-36) | 66-82 | |
| » W: Mark Langston (15-9) L: Danny Jackson (1-6) | Fifth | 9 out |
| Saturday, September 15 |
| » Lost to Royals (75-72), 8-5 | Kingdome (36-37) | 66-83 | |
| » W: Mike Jones (2-2) L: Karl Best (1-1) S: Dan Quisenberry (41) | Fifth | 10 out |
| Sunday, September 16 |
| » Lost to Royals (76-72), 4-2 | Kingdome (36-38) | 66-84 | Lost 2 |
| » W: Charlie Leibrandt (10-7) L: Salome Barojas (9-6) S: Joe Beckwith (2) | Fifth | 11 out |
| Monday, September 17 |
| » Defeated Indians (69-82), 3-2 | Kingdome (37-38) | 67-84 | |
| » W: Dave Geisel (1-1) L: Mike Jeffcoat (5-2) | Sixth | 11 out |
| Tuesday, September 18 |
| » Defeated Indians (69-83), 6-3 | Kingdome (38-38) | 68-84 | Won 2 |
| » W: Mike Moore (6-16) L: Jerry Ujdur (1-1) | Sixth | 11 out |
| Wednesday, September 19 |
| » Defeated Indians (69-84), 4-3 | Kingdome (39-38) | 69-84 | Won 3 |
| » W: Mark Langston (16-9) L: Neal Heaton (10-15) S: Dave Geisel (3) | Sixth | 10 out |
| Friday, September 21 |
| » Defeated White Sox (70-83), 5-1 | Comiskey Park I (3-1) | 70-84 | Won 4 |
| » W: Jim Beattie (12-15) L: Richard Dotson (13-15) | Sixth | 9½ out |
| Saturday, September 22 |
| » Defeated White Sox (70-84), 7-1 | Comiskey Park I (4-1) | 71-84 | Won 5 |
| » W: Matt Young (5-8) L: La Marr Hoyt (13-17) | Fourth | 9½ out |
| Sunday, September 23 |
| » Lost to White Sox (71-84), 4-0 | Comiskey Park I (4-2) | 71-85 | |
| » W: Britt Burns (4-11) L: Mike Moore (6-17) S: Ron Reed (11) | Fifth | 9½ out |
| Tuesday, September 25 |
| » Lost to Indians (70-87), 13-5 | Cleveland Stadium (1-4) | 71-86 | Lost 2 |
| » W: Neal Heaton (11-15) L: Mark Langston (16-10) | Sixth | 11½ out |
| Wednesday, September 26 |
| » Lost to Indians (71-87), 1-0 | Cleveland Stadium (1-5) | 71-87 | Lost 3 |
| » W: Bert Blyleven (18-7) L: Jim Beattie (12-16) | Sixth | 11½ out |
| Thursday, September 27 |
| » Defeated White Sox (73-86), 7-2 | Kingdome (40-38) | 72-87 | |
| » W: Matt Young (6-8) L: La Marr Hoyt (13-18) | Sixth | 11 out |
| Friday, September 28 |
| » Defeated White Sox (73-87), 7-1 | Kingdome (41-38) | 73-87 | Won 2 |
| » W: Mike Moore (7-17) L: Britt Burns (4-12) | Fifth | 11 out |
| Saturday, September 29 |
| » Lost to White Sox (74-87), 6-2 | Kingdome (41-39) | 73-88 | |
| » W: Floyd Bannister (14-11) L: Salome Barojas (9-7) | Sixth | 11 out |
| Sunday, September 30 |
| » Defeated White Sox (74-88), 5-3 | Kingdome (42-39) | 74-88 | |
| » W: Mark Langston (17-10) L: Tom Seaver (15-11) S: Edwin Nunez (7) | Fourth | 10 out |
Game information provided by Retrosheet (www.retrosheet.org) |