| Tuesday, March 20 |
| Former Indian Stan Coveleskie dies in South Bend, IN at the age of 95. |
| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Tuesday, April 3 |
| » Defeated Rangers (0-1), 9-1 | Arlington Stadium (1-0) | 1-0 | |
| » W: Rick Sutcliffe (1-0) L: Charlie Hough (0-1) | First | -- |
| Thursday, April 5 |
| » Defeated Rangers (0-2), 7-3 | Arlington Stadium (2-0) | 2-0 | Won 2 |
| » W: Neal Heaton (1-0) L: Dave Stewart (0-1) S: Dan Spillner (1) | First | -- |
| Friday, April 6 |
| » Defeated Royals (2-2), 2-0 | Royals Stadium (1-0) | 3-0 | Won 3 |
| » W: Bert Blyleven (1-0) L: Mark Gubicza (0-1) S: George Frazier (1) | First | -- |
| » Major-league debuts: Mark Gubicza (Royals) |
| Sunday, April 8 |
| » Lost to Royals (3-2), 5-4 | Royals Stadium (1-1) | 3-1 | |
| » W: Bud Black (2-0) L: George Frazier (0-1) S: Dan Quisenberry (2) | Second | 1½ out |
| Tuesday, April 10 |
| » Lost to White Sox (2-3), 7-3 | Comiskey Park I (0-1) | 3-2 | Lost 2 |
| » W: La Marr Hoyt (2-0) L: Neal Heaton (1-1) S: Ron Reed (1) | Second | 2½ out |
| Wednesday, April 11 |
| » Lost to White Sox (3-3), 6-1 | Comiskey Park I (0-2) | 3-3 | Lost 3 |
| » W: Richard Dotson (1-1) L: Bert Blyleven (1-1) | Third | 3 out |
| » Major-league debuts: Jerry Willard (Indians) |
| Saturday, April 14 |
| » Defeated Orioles (1-6), 8-2 | Cleveland Stadium (1-0) | 4-3 | |
| » W: Rick Sutcliffe (2-0) L: Scott McGregor (1-2) | Second | 3½ out |
| Sunday, April 15 |
| » Lost to Orioles (2-6), 6-5 | Cleveland Stadium (1-1) | 4-4 | |
| » W: Sammy Stewart (1-0) L: George Frazier (0-2) | Third | 4 out |
| » Major-league debuts: Tom Waddell (Indians) |
| Monday, April 16 |
| » Defeated Orioles (2-7), 4-3 | Cleveland Stadium (2-1) | 5-4 | |
| » W: Bert Blyleven (2-1) L: Mike Flanagan (0-2) S: Ernie Camacho (1) | Third | 3½ out |
| Wednesday, April 18 |
| » Lost to Yankees (5-6), 5-0 | Cleveland Stadium (2-2) | 5-5 | |
| » W: Phil Niekro (3-0) L: Rick Sutcliffe (2-1) S: Jose Rijo (1) | Third | 4½ out |
| Friday, April 20 |
| » Lost to Royals (7-6), 6-4 | Cleveland Stadium (2-3) | 5-6 | Lost 2 |
| » W: Larry Gura (3-0) L: Neal Heaton (1-2) S: Dan Quisenberry (6) | Fourth | 5 out |
| Saturday, April 21 |
| » Defeated Royals (7-7), 3-2 | Cleveland Stadium (3-3) | 6-6 | |
| » W: Bert Blyleven (3-1) L: Danny Jackson (0-1) S: Ernie Camacho (2) | Third | 5 out |
| Monday, April 23 |
| » Defeated Rangers (8-9), 3-1 | Cleveland Stadium (4-3) | 7-6 | Won 2 |
| » W: Rick Sutcliffe (3-1) L: Charlie Hough (1-2) S: Ernie Camacho (3) | Third | 5 out |
| Wednesday, April 25 |
| » Defeated White Sox (6-10), 9-2 | Cleveland Stadium (5-3) | 8-6 | Won 3 |
| » W: Neal Heaton (2-2) L: Floyd Bannister (1-2) | Third | 6 out |
| Thursday, April 26 |
| » Defeated White Sox (6-11), 5-4 | Cleveland Stadium (6-3) | 9-6 | Won 4 |
| » W: George Frazier (1-2) L: Ron Reed (0-2) | Second | 6 out |
| Friday, April 27 |
| » Defeated Tigers (16-2), 8-4 | Tiger Stadium (1-0) | 10-6 | Won 5 |
| » W: Luis Aponte (1-0) L: Glenn Abbott (1-1) | Second | 5 out |
| Saturday, April 28 |
| » Lost to Tigers (17-2), 6-2 | Tiger Stadium (1-1) | 10-7 | |
| » W: Jack Morris (5-0) L: Rick Behenna (0-1) | Third | 6 out |
| Sunday, April 29 |
| » Lost to Tigers (18-2), 6-1 | Tiger Stadium (1-2) | 10-8 | Lost 2 |
| » W: Dan Petry (3-1) L: Dan Spillner (0-1) | Third | 7 out |
| Monday, April 30 |
| » Lost to Orioles (10-13), 6-3 | Memorial Stadium (0-1) | 10-9 | Lost 3 |
| » W: Sammy Stewart (4-0) L: Ernie Camacho (0-1) S: Tippy Martinez (3) | Third | 7½ out |
| Tuesday, May 1 |
| » Lost to Orioles (11-13), 3-0 | Memorial Stadium (0-2) | 10-10 | Lost 4 |
| » W: Mike Boddicker (1-3) L: Bert Blyleven (3-2) | Third | 8½ out |
| Wednesday, May 2 |
| » Defeated Orioles (11-14), 9-7 | Memorial Stadium (1-2) | 11-10 | |
| » W: George Frazier (2-2) L: Jim Palmer (0-3) | Third | 7½ out |
| Friday, May 4 |
| » Lost to Tigers (20-4), 9-2 | Cleveland Stadium (6-4) | 11-11 | |
| » W: Dan Petry (4-1) L: Dan Spillner (0-2) S: Willie Hernandez (3) | Third | 8 out |
| Saturday, May 5 |
| » Lost to Tigers (21-4), 6-5 | Cleveland Stadium (6-5) | 11-12 | Lost 2 |
| » W: Glenn Abbott (2-1) L: Neal Heaton (2-3) S: Aurelio Lopez (3) | Fifth | 9 out |
| Sunday, May 6 |
| » Lost to Tigers (22-4), 6-5 | Cleveland Stadium (6-6) | 11-13 | Lost 3 |
| » W: Aurelio Lopez (3-0) L: Ernie Camacho (0-2) | Fifth | 10 out |
| Monday, May 7 |
| » Lost to Yankees (10-17), 5-2 | Yankee Stadium (0-1) | 11-14 | Lost 4 |
| » W: Shane Rawley (1-2) L: Rick Behenna (0-2) S: Jay Howell (1) | Fifth | 11 out |
| Wednesday, May 9 |
| » Lost to Yankees (11-17), 11-4 | Yankee Stadium (0-2) | 11-15 | Lost 5 |
| » W: Phil Niekro (5-1) L: Rick Sutcliffe (3-2) | Sixth | 12½ out |
| Thursday, May 10 |
| » Lost to Yankees (12-17), 7-6 | Yankee Stadium (0-3) | 11-16 | Lost 6 |
| » W: Jose Rijo (1-3) L: Tom Waddell (0-1) | Seventh | 13 out |
| Saturday, May 12 |
| » Defeated Blue Jays (19-13), 8-4 | Cleveland Stadium (7-6) | 12-16 | |
| » W: Bert Blyleven (4-2) L: Jim Acker (0-2) S: Ernie Camacho (4) | Fifth | 12½ out |
| Sunday, May 13 |
| » Tied Blue Jays, 4-4 | Cleveland Stadium (7-6) | 12-16 | |
| » Starters: Jim Clancy vs Rick Sutcliffe | Fifth | 12½ out |
| Monday, May 14 |
| » Lost to Red Sox (14-20), 6-1 | Cleveland Stadium (7-7) | 12-17 | |
| » W: Bob Ojeda (4-2) L: Rick Behenna (0-3) S: Bob Stanley (6) | Sixth | 13½ out |
| Tuesday, May 15 |
| » Defeated Red Sox (14-21), 7-5 | Cleveland Stadium (8-7) | 13-17 | |
| » W: Tom Waddell (1-1) L: John Henry Johnson (0-1) S: Ernie Camacho (5) | Sixth | 13½ out |
| » Major-league debuts: Roger Clemens (Red Sox) |
| Wednesday, May 16 |
| » Lost to Red Sox (15-21), 5-2 | Cleveland Stadium (8-8) | 13-18 | |
| » W: Dennis Eckersley (3-4) L: Steve Farr (0-1) S: Bob Stanley (7) | Sixth | 14½ out |
| » Major-league debuts: Steve Farr (Indians) |
| Thursday, May 17 |
| » Lost to Red Sox (16-21), 11-10 | Cleveland Stadium (8-9) | 13-19 | Lost 2 |
| » W: Steve Crawford (1-0) L: Ernie Camacho (0-3) | Seventh | 15 out |
| Friday, May 18 |
| » Defeated Brewers (17-18), 8-4 | County Stadium (1-0) | 14-19 | |
| » W: Mike Jeffcoat (1-0) L: Pete Ladd (2-2) | Sixth | 15 out |
| Saturday, May 19 |
| » Lost to Brewers (18-18), 3-0 | County Stadium (1-1) | 14-20 | |
| » W: Jaime Cocanower (3-4) L: Dan Spillner (0-3) S: Rollie Fingers (8) | Sixth | 16 out |
| Sunday, May 20 |
| » Defeated Brewers (18-19), 3-2 | County Stadium (2-1) | 15-20 | |
| » W: Ernie Camacho (1-3) L: Don Sutton (3-3) S: Tom Waddell (1) | Fifth | 16 out |
| Monday, May 21 |
| » Lost to Red Sox (18-23), 6-3 | Fenway Park (0-1) | 15-21 | |
| » W: Dennis Eckersley (4-4) L: Steve Farr (0-2) | Seventh | 16½ out |
| Tuesday, May 22 |
| » Lost to Red Sox (19-23), 7-1 | Fenway Park (0-2) | 15-22 | Lost 2 |
| » W: Bruce Hurst (5-4) L: Rick Sutcliffe (3-3) | Seventh | 17½ out |
| Wednesday, May 23 |
| » Defeated Red Sox (19-24), 5-4 | Fenway Park (1-2) | 16-22 | |
| » W: Tom Waddell (2-1) L: Bob Stanley (1-3) S: Ernie Camacho (6) | Seventh | 17½ out |
| Friday, May 25 |
| » Lost to Blue Jays (28-14), 5-1 | Exhibition Stadium (0-1) | 16-23 | |
| » W: Dave Stieb (6-1) L: Neal Heaton (2-4) | Seventh | 18 out |
| Saturday, May 26 |
| » Lost to Blue Jays (29-14), 2-1 | Exhibition Stadium (0-2) | 16-24 | Lost 2 |
| » W: Doyle Alexander (4-1) L: Steve Farr (0-3) S: Jimmy Key (3) | Seventh | 18 out |
| Sunday, May 27 |
| » Lost to Blue Jays (30-14), 6-1 | Exhibition Stadium (0-3) | 16-25 | Lost 3 |
| » W: Luis Leal (5-0) L: Rick Sutcliffe (3-4) | Seventh | 18½ out |
| » Lost to Blue Jays (31-14), 6-5 | Exhibition Stadium (0-4) | 16-26 | Lost 4 |
| » W: Roy Lee Jackson (6-1) L: Ernie Camacho (1-4) | Seventh | 18½ out |
| Tuesday, May 29 |
| » Lost to Brewers (21-23), 5-3 | Cleveland Stadium (8-10) | 16-27 | Lost 5 |
| » W: Moose Haas (3-4) L: Dan Spillner (0-4) | Seventh | 19 out |
| Wednesday, May 30 |
| » Defeated Brewers (21-24), 9-1 | Cleveland Stadium (9-10) | 17-27 | |
| » W: Neal Heaton (3-4) L: Mike Caldwell (4-5) | Seventh | 19½ out |
| » Lost to Brewers (22-24), 3-2 | Cleveland Stadium (9-11) | 17-28 | |
| » W: Jaime Cocanower (4-5) L: Tom Waddell (2-2) S: Pete Ladd (2) | Seventh | 19½ out |
| Friday, June 1 |
| » Lost to Angels (27-25), 5-2 | Cleveland Stadium (9-12) | 17-29 | Lost 2 |
| » W: Mike Witt (5-5) L: Rick Sutcliffe (3-5) S: Doug Corbett (2) | Seventh | 20½ out |
| Saturday, June 2 |
| » Lost to Angels (28-25), 6-4 | Cleveland Stadium (9-13) | 17-30 | Lost 3 |
| » W: Luis Sanchez (5-1) L: Ernie Camacho (1-5) | Seventh | 20½ out |
| Sunday, June 3 |
| » Lost to Angels (29-25), 7-4 | Cleveland Stadium (9-14) | 17-31 | Lost 4 |
| » W: Curt Kaufman (1-2) L: Dan Spillner (0-5) | Seventh | 20½ out |
| Monday, June 4 |
| » Lost to Athletics (25-29), 7-3 | Cleveland Stadium (9-15) | 17-32 | Lost 5 |
| » W: Bill Krueger (4-1) L: Neal Heaton (3-5) S: Bill Caudill (12) | Seventh | 21½ out |
| Tuesday, June 5 |
| » Lost to Athletics (26-29), 4-2 | Cleveland Stadium (9-16) | 17-33 | Lost 6 |
| » W: Keith Atherton (3-2) L: Mike Jeffcoat (1-1) | Seventh | 21½ out |
| Wednesday, June 6 |
| » Defeated Athletics (26-30), 7-6 | Cleveland Stadium (10-16) | 18-33 | |
| » W: Mike Jeffcoat (2-1) L: Jeff Jones (0-2) S: Ernie Camacho (7) | Seventh | 20½ out |
| Friday, June 8 |
| » Defeated Mariners (27-31), 4-3 | Cleveland Stadium (11-16) | 19-33 | Won 2 |
| » W: Steve Comer (1-0) L: Jim Beattie (4-7) S: Ernie Camacho (8) | Seventh | 21 out |
| Saturday, June 9 |
| » Defeated Mariners (27-32), 8-7 | Cleveland Stadium (12-16) | 20-33 | Won 3 |
| » W: George Frazier (3-2) L: Mark Langston (3-5) S: Steve Farr (1) | Sixth | 20 out |
| Sunday, June 10 |
| » Defeated Mariners (27-33), 3-1 | Cleveland Stadium (13-16) | 21-33 | Won 4 |
| » W: Neal Heaton (4-5) L: Ed Vande Berg (4-5) S: Mike Jeffcoat (1) | Seventh | 21 out |
| » Lost to Mariners (28-33), 4-3 | Cleveland Stadium (13-17) | 21-34 | |
| » W: Mark Langston (4-5) L: Ernie Camacho (1-6) S: Mike Stanton (3) | Seventh | 21 out |
| Tuesday, June 12 |
| » Defeated Athletics (26-35), 11-5 | Oakland-Alameda County Stadium (1-0) | 22-34 | |
| » W: Rick Sutcliffe (4-5) L: Tim Conroy (0-3) | Seventh | 20½ out |
| Wednesday, June 13 |
| » Lost to Athletics (27-35), 3-1 | Oakland-Alameda County Stadium (1-1) | 22-35 | |
| » W: Bill Caudill (6-1) L: Bert Blyleven (4-3) | Seventh | 20½ out |
| Thursday, June 14 |
| » Lost to Athletics (28-35), 7-6 | Oakland-Alameda County Stadium (1-2) | 22-36 | Lost 2 |
| » W: Keith Atherton (4-3) L: Ernie Camacho (1-7) S: Bill Caudill (13) | Seventh | 21 out |
| Friday, June 15 |
| » Lost to Angels (35-29), 5-2 | Anaheim Stadium (0-1) | 22-37 | Lost 3 |
| » W: Geoff Zahn (8-3) L: Neal Heaton (4-6) S: Luis Sanchez (7) | Seventh | 22 out |
| Saturday, June 16 |
| » Lost to Angels (36-29), 7-2 | Anaheim Stadium (0-2) | 22-38 | Lost 4 |
| » W: Jim Slaton (2-2) L: Steve Farr (0-4) S: Bruce Kison (1) | Seventh | 23 out |
| Sunday, June 17 |
| » Defeated Angels (36-30), 4-3 | Anaheim Stadium (1-2) | 23-38 | |
| » W: Ernie Camacho (2-7) L: Mike Witt (5-7) | Seventh | 23 out |
| Former Indian Jim Hegan dies in Swampscott, MA at the age of 64. |
| Tuesday, June 19 |
| » Defeated Twins (32-34), 7-4 | Hubert H. Humphrey Metrodome (1-0) | 24-38 | Won 2 |
| » W: Bert Blyleven (5-3) L: Ken Schrom (0-2) S: Ernie Camacho (9) | Seventh | 22½ out |
| Wednesday, June 20 |
| » Lost to Twins (33-34), 8-2 | Hubert H. Humphrey Metrodome (1-1) | 24-39 | |
| » W: Frank Viola (6-7) L: Steve Comer (1-1) | Seventh | 23½ out |
| Thursday, June 21 |
| » Defeated Twins (33-35), 7-0 | Hubert H. Humphrey Metrodome (2-1) | 25-39 | |
| » W: Neal Heaton (5-6) L: John Butcher (5-5) | Seventh | 22½ out |
| Friday, June 22 |
| » Defeated Mariners (33-38), 13-3 | Kingdome (1-0) | 26-39 | Won 2 |
| » W: Mike Jeffcoat (3-1) L: Ed Vande Berg (4-7) | Seventh | 22½ out |
| Saturday, June 23 |
| » Defeated Mariners (33-39), 11-4 | Kingdome (2-0) | 27-39 | Won 3 |
| » W: Roy Smith (1-0) L: Mike Moore (3-5) | Seventh | 22½ out |
| » Major-league debuts: Roy Smith (Indians) |
| Sunday, June 24 |
| » Defeated Mariners (33-40), 5-0 | Kingdome (3-0) | 28-39 | Won 4 |
| » W: Bert Blyleven (6-3) L: Bob Stoddard (1-3) | Seventh | 22½ out |
| » Major-league debuts: Jim Presley (Mariners) |
| Tuesday, June 26 |
| » Lost to Twins (36-36), 8-3 | Cleveland Stadium (13-18) | 28-40 | |
| » W: Frank Viola (7-7) L: Steve Comer (1-2) S: Ron Davis (14) | Seventh | 23 out |
| Wednesday, June 27 |
| » Defeated Twins (36-37), 6-4 | Cleveland Stadium (14-18) | 29-40 | |
| » W: Ernie Camacho (3-7) L: Ron Davis (3-6) | Seventh | 22 out |
| Thursday, June 28 |
| » Lost to Rangers (34-42), 10-6 | Cleveland Stadium (14-19) | 29-41 | |
| » W: Dave Schmidt (3-3) L: Don Schulze (0-1) | Seventh | 22 out |
| » Defeated Rangers (34-43), 7-2 | Cleveland Stadium (15-19) | 30-41 | |
| » W: Roy Smith (2-0) L: Frank Tanana (8-7) S: Ernie Camacho (10) | Seventh | 22 out |
| Friday, June 29 |
| » Defeated Rangers (34-44), 13-12 | Cleveland Stadium (16-19) | 31-41 | Won 2 |
| » W: Jamie Easterly (1-0) L: Dave Tobik (1-6) | Seventh | 21½ out |
| Saturday, June 30 |
| » Lost to Rangers (35-44), 2-1 | Cleveland Stadium (16-20) | 31-42 | |
| » W: Charlie Hough (8-6) L: Steve Comer (1-3) | Seventh | 22½ out |
| Sunday, July 1 |
| » Defeated Rangers (35-45), 13-5 | Cleveland Stadium (17-20) | 32-42 | |
| » W: Don Schulze (1-1) L: Mike Mason (5-6) | Seventh | 21½ out |
| Monday, July 2 |
| » Lost to Royals (35-40), 9-3 | Cleveland Stadium (17-21) | 32-43 | |
| » W: Larry Gura (9-4) L: Neal Heaton (5-7) | Seventh | 22 out |
| » Lost to Royals (36-40), 4-3 | Cleveland Stadium (17-22) | 32-44 | Lost 2 |
| » W: Mark Huismann (1-2) L: Roy Smith (2-1) S: Dan Quisenberry (22) | Seventh | 22 out |
| Tuesday, July 3 |
| » Defeated Royals (36-41), 15-3 | Cleveland Stadium (18-22) | 33-44 | |
| » W: Bert Blyleven (7-3) L: Bud Black (9-6) | Seventh | 21 out |
| Wednesday, July 4 |
| » Lost to Royals (37-41), 4-0 | Cleveland Stadium (18-23) | 33-45 | |
| » W: Bret Saberhagen (3-7) L: Steve Comer (1-4) | Seventh | 21 out |
| Thursday, July 5 |
| » Lost to White Sox (41-40), 7-6 | Comiskey Park I (0-3) | 33-46 | Lost 2 |
| » W: Gene Nelson (1-0) L: Neal Heaton (5-8) | Seventh | 22 out |
| Friday, July 6 |
| » Lost to White Sox (42-40), 11-6 | Comiskey Park I (0-4) | 33-47 | Lost 3 |
| » W: La Marr Hoyt (8-8) L: Don Schulze (1-2) S: Ron Reed (5) | Seventh | 22 out |
| Saturday, July 7 |
| » Lost to White Sox (43-40), 4-2 | Comiskey Park I (0-5) | 33-48 | Lost 4 |
| » W: Floyd Bannister (6-6) L: Roy Smith (2-2) S: Gene Nelson (1) | Seventh | 23 out |
| Sunday, July 8 |
| » Lost to White Sox (44-40), 9-8 | Comiskey Park I (0-6) | 33-49 | Lost 5 |
| » W: Juan Agosto (2-0) L: Steve Farr (0-5) | Seventh | 23 out |
| Thursday, July 12 |
| » Lost to Rangers (39-49), 7-2 | Arlington Stadium (2-1) | 33-50 | Lost 6 |
| » W: Charlie Hough (9-7) L: Neal Heaton (5-9) | Seventh | 23 out |
| Friday, July 13 |
| » Defeated Rangers (39-50), 5-0 | Arlington Stadium (3-1) | 34-50 | |
| » W: Bert Blyleven (8-3) L: Mike Mason (6-7) | Seventh | 23 out |
| Saturday, July 14 |
| » Defeated Rangers (39-51), 5-0 | Arlington Stadium (4-1) | 35-50 | Won 2 |
| » W: Steve Farr (1-5) L: Dave Stewart (4-10) | Seventh | 23 out |
| Sunday, July 15 |
| » Defeated Rangers (39-52), 5-4 | Arlington Stadium (5-1) | 36-50 | Won 3 |
| » W: Ernie Camacho (4-7) L: Odell Jones (1-4) S: Jamie Easterly (1) | Seventh | 23 out |
| Monday, July 16 |
| » Lost to Royals (40-48), 3-1 | Royals Stadium (1-2) | 36-51 | |
| » W: Mike Jones (1-1) L: Don Schulze (1-3) S: Dan Quisenberry (24) | Seventh | 24 out |
| Tuesday, July 17 |
| » Defeated Royals (40-49), 9-7 | Royals Stadium (2-2) | 37-51 | |
| » W: Neal Heaton (6-9) L: Larry Gura (9-7) S: Ernie Camacho (11) | Seventh | 23½ out |
| » Defeated Royals (40-50), 6-2 | Royals Stadium (3-2) | 38-51 | Won 2 |
| » W: Steve Comer (2-4) L: Frank Wills (0-1) S: Tom Waddell (2) | Seventh | 23½ out |
| Wednesday, July 18 |
| » Defeated Royals (40-51), 2-1 | Royals Stadium (4-2) | 39-51 | Won 3 |
| » W: Bert Blyleven (9-3) L: Bud Black (10-8) S: Tom Waddell (3) | Seventh | 22½ out |
| Thursday, July 19 |
| » Lost to White Sox (47-46), 3-0 | Cleveland Stadium (18-24) | 39-52 | |
| » W: Tom Seaver (9-6) L: Steve Farr (1-6) S: Jerry Don Gleaton (1) | Seventh | 23½ out |
| Friday, July 20 |
| » Defeated White Sox (47-47), 6-3 | Cleveland Stadium (19-24) | 40-52 | |
| » W: Roy Smith (3-2) L: Richard Dotson (11-6) | Seventh | 23½ out |
| Saturday, July 21 |
| » Lost to White Sox (48-47), 4-3 | Cleveland Stadium (19-25) | 40-53 | |
| » W: Jerry Don Gleaton (1-0) L: Tom Waddell (2-3) S: Ron Reed (6) | Seventh | 24½ out |
| Sunday, July 22 |
| » Defeated White Sox (48-48), 4-1 | Cleveland Stadium (20-25) | 41-53 | |
| » W: Neal Heaton (7-9) L: Gene Nelson (1-3) | Seventh | 24½ out |
| Monday, July 23 |
| » Lost to Tigers (67-29), 4-1 | Cleveland Stadium (20-26) | 41-54 | |
| » W: Jack Morris (13-6) L: Bert Blyleven (9-4) S: Doug Bair (4) | Seventh | 25½ out |
| Tuesday, July 24 |
| » Lost to Tigers (68-29), 9-5 | Cleveland Stadium (20-27) | 41-55 | Lost 2 |
| » W: Milt Wilcox (10-6) L: Steve Farr (1-7) | Seventh | 26½ out |
| Wednesday, July 25 |
| » Defeated Tigers (68-30), 4-1 | Cleveland Stadium (21-27) | 42-55 | |
| » W: Roy Smith (4-2) L: Dave Rozema (7-2) S: Ernie Camacho (12) | Seventh | 25½ out |
| Friday, July 27 |
| » Lost to Orioles (56-45), 4-3 | Memorial Stadium (1-3) | 42-56 | |
| » W: Storm Davis (10-4) L: Neal Heaton (7-10) | Seventh | 26 out |
| Saturday, July 28 |
| » Defeated Orioles (56-46), 6-3 | Memorial Stadium (2-3) | 43-56 | |
| » W: Bert Blyleven (10-4) L: Scott McGregor (12-9) S: Tom Waddell (4) | Seventh | 25 out |
| Sunday, July 29 |
| » Lost to Orioles (57-46), 3-1 | Memorial Stadium (2-4) | 43-57 | |
| » W: Mike Boddicker (12-8) L: Steve Comer (2-5) S: Sammy Stewart (6) | Seventh | 26 out |
| Tuesday, July 31 |
| » Lost to Tigers (71-32), 5-1 | Tiger Stadium (1-3) | 43-58 | Lost 2 |
| » W: Juan Berenguer (5-7) L: Roy Smith (4-3) | Seventh | 26 out |
| » Defeated Tigers (71-33), 6-4 | Tiger Stadium (2-3) | 44-58 | |
| » W: Neal Heaton (8-10) L: Dave Rozema (7-3) S: Tom Waddell (5) | Seventh | 26 out |
| Wednesday, August 1 |
| » Defeated Tigers (71-34), 4-2 | Tiger Stadium (3-3) | 45-58 | Won 2 |
| » W: Steve Farr (2-7) L: Dan Petry (14-5) S: Ernie Camacho (13) | Seventh | 25 out |
| Thursday, August 2 |
| » Lost to Tigers (72-34), 2-1 | Tiger Stadium (3-4) | 45-59 | |
| » W: Jack Morris (14-7) L: Bert Blyleven (10-5) S: Willie Hernandez (22) | Seventh | 26 out |
| Friday, August 3 |
| » Lost to Yankees (53-52), 9-0 | Yankee Stadium (0-4) | 45-60 | Lost 2 |
| » W: Joe Cowley (2-1) L: Steve Comer (2-6) | Seventh | 26½ out |
| » Lost to Yankees (54-52), 3-2 | Yankee Stadium (0-5) | 45-61 | Lost 3 |
| » W: Mike Armstrong (3-0) L: Ernie Camacho (4-8) S: Dave Righetti (18) | Seventh | 26½ out |
| Former Indian Elmer Smith dies in Columbia, KY at the age of 92. |
| Saturday, August 4 |
| » Lost to Yankees (55-52), 8-5 | Yankee Stadium (0-6) | 45-62 | Lost 4 |
| » W: Dennis Rasmussen (6-3) L: Roy Smith (4-4) S: Dave Righetti (19) | Seventh | 26½ out |
| Sunday, August 5 |
| » Lost to Yankees (56-52), 4-0 | Yankee Stadium (0-7) | 45-63 | Lost 5 |
| » W: Ray Fontenot (5-6) L: Neal Heaton (8-11) | Seventh | 26 out |
| Monday, August 6 |
| » Lost to Orioles (59-51), 4-2 | Cleveland Stadium (21-28) | 45-64 | Lost 6 |
| » W: Storm Davis (12-4) L: Steve Farr (2-8) | Seventh | 26½ out |
| Tuesday, August 7 |
| » Defeated Orioles (59-52), 5-4 | Cleveland Stadium (22-28) | 46-64 | |
| » W: Bert Blyleven (11-5) L: Scott McGregor (12-11) S: Ernie Camacho (14) | Sixth | 26 out |
| Wednesday, August 8 |
| » Lost to Orioles (60-52), 7-4 | Cleveland Stadium (22-29) | 46-65 | |
| » W: Mike Boddicker (13-8) L: Steve Comer (2-7) S: Tippy Martinez (15) | Seventh | 26 out |
| Thursday, August 9 |
| » Defeated Orioles (60-53), 7-5 | Cleveland Stadium (23-29) | 47-65 | |
| » W: Jamie Easterly (2-0) L: Mark Brown (0-1) S: Ernie Camacho (15) | Sixth | 25½ out |
| Friday, August 10 |
| » Lost to Yankees (59-54), 6-4 | Cleveland Stadium (23-30) | 47-66 | |
| » W: Joe Cowley (3-1) L: Don Schulze (1-4) S: Jay Howell (5) | Sixth | 27 out |
| » Lost to Yankees (60-54), 10-1 | Cleveland Stadium (23-31) | 47-67 | Lost 2 |
| » W: Ray Fontenot (6-6) L: Neal Heaton (8-12) | Sixth | 27 out |
| Saturday, August 11 |
| » Lost to Yankees (61-54), 10-1 | Cleveland Stadium (23-32) | 47-68 | Lost 3 |
| » W: Phil Niekro (14-6) L: Steve Farr (2-9) | Sixth | 28 out |
| Sunday, August 12 |
| » Defeated Yankees (61-55), 6-0 | Cleveland Stadium (24-32) | 48-68 | |
| » W: Bert Blyleven (12-5) L: Ron Guidry (10-9) | Fifth | 28 out |
| Monday, August 13 |
| » Defeated Yankees (61-56), 6-5 | Cleveland Stadium (25-32) | 49-68 | Won 2 |
| » W: Steve Farr (3-9) L: Dave Righetti (2-4) | Sixth | 27½ out |
| Tuesday, August 14 |
| » Lost to Blue Jays (67-49), 8-1 | Cleveland Stadium (25-33) | 49-69 | |
| » W: Doyle Alexander (11-5) L: Neal Heaton (8-13) | Sixth | 27½ out |
| » Lost to Blue Jays (68-49), 9-5 | Cleveland Stadium (25-34) | 49-70 | Lost 2 |
| » W: Dennis Lamp (5-6) L: Tom Waddell (2-4) | Sixth | 27½ out |
| Wednesday, August 15 |
| » Defeated Blue Jays (68-50), 16-1 | Cleveland Stadium (26-34) | 50-70 | |
| » W: Don Schulze (2-4) L: Luis Leal (12-3) | Fifth | 27 out |
| » Defeated Blue Jays (68-51), 4-3 | Cleveland Stadium (27-34) | 51-70 | Won 2 |
| » W: Mike Jeffcoat (4-1) L: Jimmy Key (3-5) | Fifth | 27 out |
| Thursday, August 16 |
| » Defeated Blue Jays (68-52), 6-5 | Cleveland Stadium (28-34) | 52-70 | Won 3 |
| » W: Tom Waddell (3-4) L: Dennis Lamp (5-7) | Sixth | 27 out |
| Friday, August 17 |
| » Defeated Brewers (52-70), 5-3 | Cleveland Stadium (29-34) | 53-70 | Won 4 |
| » W: Bert Blyleven (13-5) L: Jaime Cocanower (8-13) S: Ernie Camacho (16) | Fifth | 27 out |
| Sunday, August 19 |
| » Defeated Brewers (52-71), 8-6 | Cleveland Stadium (30-34) | 54-70 | Won 5 |
| » W: Tom Waddell (4-4) L: Pete Ladd (4-8) | Sixth | 26 out |
| » Defeated Brewers (52-72), 2-1 | Cleveland Stadium (31-34) | 55-70 | Won 6 |
| » W: Steve Comer (3-7) L: Rick Waits (2-3) | Sixth | 26 out |
| Tuesday, August 21 |
| » Defeated Blue Jays (70-54), 3-1 | Exhibition Stadium (1-4) | 56-70 | Won 7 |
| » W: Roy Smith (5-4) L: Dave Stieb (12-5) S: Ernie Camacho (17) | Fifth | 26½ out |
| Wednesday, August 22 |
| » Defeated Blue Jays (70-55), 13-3 | Exhibition Stadium (2-4) | 57-70 | Won 8 |
| » W: Bert Blyleven (14-5) L: Jim Clancy (10-13) | Sixth | 26½ out |
| » Major-league debuts: Junior Noboa (Indians) |
| Thursday, August 23 |
| » Lost to Blue Jays (71-55), 6-1 | Exhibition Stadium (2-5) | 57-71 | |
| » W: Doyle Alexander (12-5) L: Don Schulze (2-5) | Sixth | 27 out |
| Friday, August 24 |
| » Lost to Red Sox (66-62), 7-6 | Fenway Park (1-3) | 57-72 | Lost 2 |
| » W: Oil Can Boyd (8-9) L: Steve Comer (3-8) S: Mark Clear (7) | Sixth | 27 out |
| Saturday, August 25 |
| » Lost to Red Sox (67-62), 11-6 | Fenway Park (1-4) | 57-73 | Lost 3 |
| » W: Al Nipper (6-5) L: Steve Farr (3-10) S: Steve Crawford (1) | Sixth | 28 out |
| Sunday, August 26 |
| » Lost to Red Sox (68-62), 4-2 | Fenway Park (1-5) | 57-74 | Lost 4 |
| » W: Roger Clemens (9-4) L: Roy Smith (5-5) | Sixth | 29 out |
| Monday, August 27 |
| » Defeated Brewers (55-76), 7-1 | County Stadium (3-1) | 58-74 | |
| » W: Bert Blyleven (15-5) L: Mike Caldwell (6-12) | Sixth | 28½ out |
| Tuesday, August 28 |
| » Defeated Brewers (55-77), 8-5 | County Stadium (4-1) | 59-74 | Won 2 |
| » W: Neal Heaton (9-13) L: Bob McClure (4-6) S: Ernie Camacho (18) | Sixth | 28½ out |
| Wednesday, August 29 |
| » Defeated Brewers (55-78), 5-2 | County Stadium (5-1) | 60-74 | Won 3 |
| » W: Mike Jeffcoat (5-1) L: Jaime Cocanower (8-14) S: Ernie Camacho (19) | Fifth | 27½ out |
| Thursday, August 30 |
| » Lost to Brewers (56-78), 7-6 | County Stadium (5-2) | 60-75 | |
| » W: Tom Tellmann (5-3) L: Steve Farr (3-11) S: Pete Ladd (3) | Fifth | 27½ out |
| Friday, August 31 |
| » Lost to Red Sox (71-63), 8-7 | Cleveland Stadium (31-35) | 60-76 | Lost 2 |
| » W: Bob Stanley (8-10) L: Ernie Camacho (4-9) | Sixth | 27½ out |
| Saturday, September 1 |
| » Lost to Red Sox (72-63), 4-1 | Cleveland Stadium (31-36) | 60-77 | Lost 3 |
| » W: Bob Ojeda (10-10) L: Bert Blyleven (15-6) | Sixth | 27½ out |
| Sunday, September 2 |
| » Defeated Red Sox (72-64), 8-3 | Cleveland Stadium (32-36) | 61-77 | |
| » W: Tom Waddell (5-4) L: Mark Clear (7-3) | Sixth | 27½ out |
| Monday, September 3 |
| » Defeated Angels (67-69), 6-5 | Cleveland Stadium (33-36) | 62-77 | Won 2 |
| » W: Steve Comer (4-8) L: Jim Slaton (6-7) S: Jamie Easterly (2) | Sixth | 26½ out |
| Tuesday, September 4 |
| » Lost to Angels (68-69), 5-3 | Cleveland Stadium (33-37) | 62-78 | |
| » W: Don Aase (3-1) L: Jamie Easterly (2-1) | Sixth | 26½ out |
| Wednesday, September 5 |
| » Lost to Angels (69-69), 11-4 | Cleveland Stadium (33-38) | 62-79 | Lost 2 |
| » W: Bruce Kison (4-3) L: Jose Roman (0-1) | Sixth | 27½ out |
| » Major-league debuts: Jose Roman (Indians) |
| Friday, September 7 |
| » Defeated Athletics (65-77), 13-2 | Cleveland Stadium (34-38) | 63-79 | |
| » W: Bert Blyleven (16-6) L: Tim Conroy (1-5) | Fifth | 27½ out |
| Saturday, September 8 |
| » Lost to Athletics (66-77), 9-5 | Cleveland Stadium (34-39) | 63-80 | |
| » W: Chris Codiroli (3-3) L: Neal Heaton (9-14) S: Bill Caudill (29) | Fifth | 28½ out |
| Sunday, September 9 |
| » Defeated Athletics (66-78), 7-5 | Cleveland Stadium (35-39) | 64-80 | |
| » W: Jamie Easterly (3-1) L: Steve McCatty (7-14) S: Tom Waddell (6) | Sixth | 28½ out |
| Tuesday, September 11 |
| » Defeated Angels (71-71), 4-2 | Anaheim Stadium (2-2) | 65-80 | Won 2 |
| » W: Don Schulze (3-5) L: Ron Romanick (10-12) | Sixth | 28 out |
| Former Indian Paul Carter dies in Lake Park, GA at the age of 91. |
| Wednesday, September 12 |
| » Defeated Angels (71-72), 7-1 | Anaheim Stadium (3-2) | 66-80 | Won 3 |
| » W: Bert Blyleven (17-6) L: Bruce Kison (4-4) | Sixth | 27 out |
| Thursday, September 13 |
| » Lost to Angels (72-72), 7-3 | Anaheim Stadium (3-3) | 66-81 | |
