| Saturday, January 28 |
| Former Giant Ray Harrell dies in Alexandria, LA at the age of 72. |
| Sunday, February 19 |
| Former Giant Bill Shores dies in Purcell, OK at the age of 80. |
| Friday, March 30 |
| Former Giant Hugh Poland dies in Guthrie, KY at the age of 72. |
| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Tuesday, April 3 |
| » Lost to Cubs (1-0), 5-3 | Candlestick Park (0-1) | 0-1 | |
| » W: Dick Ruthven (1-0) L: Mark Davis (0-1) S: Lee Smith (1) | Second | 1 out |
| Thursday, April 5 |
| » Lost to Cubs (2-0), 11-7 | Candlestick Park (0-2) | 0-2 | Lost 2 |
| » W: Chuck Rainey (1-0) L: Mike Krukow (0-1) S: Lee Smith (2) | Third | 2 out |
| » Major-league debuts: Frank Williams (Giants) Henry Cotto (Cubs) |
| Friday, April 6 |
| » Lost to Cardinals (2-1), 2-0 | Candlestick Park (0-3) | 0-3 | Lost 3 |
| » W: Joaquin Andujar (1-0) L: Bill Laskey (0-1) | Third | 3 out |
| Saturday, April 7 |
| » Defeated Cardinals (2-2), 11-0 | Candlestick Park (1-3) | 1-3 | |
| » W: Jeff Robinson (1-0) L: Dave LaPoint (0-1) | Second | 3 out |
| » Major-league debuts: Jeff Robinson (Giants) Rick Horton (Cardinals) |
| Sunday, April 8 |
| » Lost to Cardinals (3-2), 9-3 | Candlestick Park (1-4) | 1-4 | |
| » W: Neil Allen (1-0) L: Mark Davis (0-2) | Third | 3 out |
| Tuesday, April 10 |
| » Defeated Pirates (3-3), 4-3 | Candlestick Park (2-4) | 2-4 | |
| » W: Mike Krukow (1-1) L: Larry McWilliams (0-1) S: Greg Minton (1) | Third | 3 out |
| Wednesday, April 11 |
| » Defeated Pirates (3-4), 2-1 | Candlestick Park (3-4) | 3-4 | Won 2 |
| » W: Gary Lavelle (1-0) L: Cecilio Guante (0-1) | Third | 3 out |
| Friday, April 13 |
| » Lost to Dodgers (4-4), 2-0 | Dodger Stadium (0-1) | 3-5 | |
| » W: Bob Welch (1-1) L: Jeff Robinson (1-1) S: Tom Niedenfuer (2) | Fourth | 4½ out |
| Saturday, April 14 |
| » Lost to Dodgers (5-4), 8-4 | Dodger Stadium (0-2) | 3-6 | Lost 2 |
| » W: Alejandro Pena (1-1) L: Mike Krukow (1-2) | Fourth | 4½ out |
| Sunday, April 15 |
| » Defeated Dodgers (5-5), 8-6 | Dodger Stadium (1-2) | 4-6 | |
| » W: Randy Lerch (1-0) L: Tom Niedenfuer (0-1) S: Frank Williams (1) | Third | 4½ out |
| Tuesday, April 17 |
| » Lost to Padres (10-2), 2-1 | Candlestick Park (3-5) | 4-7 | |
| » W: Tim Lollar (2-0) L: Mark Davis (0-3) S: Rich Gossage (5) | Third | 5½ out |
| Thursday, April 19 |
| » Defeated Reds (4-9), 3-1 | Candlestick Park (4-5) | 5-7 | |
| » W: Jeff Robinson (2-1) L: Bruce Berenyi (0-3) S: Gary Lavelle (1) | Third | 4½ out |
| Friday, April 20 |
| » Defeated Reds (4-10), 6-4 | Candlestick Park (5-5) | 6-7 | Won 2 |
| » W: Greg Minton (1-0) L: Jeff Russell (1-2) S: Gary Lavelle (2) | Third | 3½ out |
| Saturday, April 21 |
| » Lost to Reds (5-10), 5-4 | Candlestick Park (5-6) | 6-8 | |
| » W: Ted Power (1-0) L: Greg Minton (1-1) S: Tom Hume (2) | Third | 4½ out |
| Sunday, April 22 |
| » Defeated Reds (5-11), 9-5 | Candlestick Park (6-6) | 7-8 | |
| » W: Renie Martin (1-0) L: Frank Pastore (0-2) S: Gary Lavelle (3) | Third | 3½ out |
| Monday, April 23 |
| » Lost to Padres (12-5), 8-2 | San Diego/Jack Murphy Stadium (0-1) | 7-9 | |
| » W: Andy Hawkins (2-0) L: Jeff Robinson (2-2) | Third | 4½ out |
| Tuesday, April 24 |
| » Lost to Padres (13-5), 6-1 | San Diego/Jack Murphy Stadium (0-2) | 7-10 | Lost 2 |
| » W: Ed Whitson (2-1) L: Mike Krukow (1-3) | Third | 5½ out |
| Wednesday, April 25 |
| » Lost to Padres (14-5), 3-0 | San Diego/Jack Murphy Stadium (0-3) | 7-11 | Lost 3 |
| » W: Eric Show (3-1) L: Bill Laskey (0-2) S: Rich Gossage (7) | Third | 6½ out |
| Friday, April 27 |
| » Lost to Reds (7-13), 9-3 | Riverfront Stadium (0-1) | 7-12 | Lost 4 |
| » W: Joe Price (2-1) L: Mark Grant (0-1) S: Brad Lesley (2) | Fourth | 6½ out |
| » Major-league debuts: Mark Grant (Giants) |
| Saturday, April 28 |
| » Lost to Reds (8-13), 7-6 | Riverfront Stadium (0-2) | 7-13 | Lost 5 |
| » W: Tom Hume (1-3) L: Randy Lerch (1-1) | Fifth | 7 out |
| Sunday, April 29 |
| » Lost to Reds (9-13), 8-1 | Riverfront Stadium (0-3) | 7-14 | Lost 6 |
| » W: Bruce Berenyi (1-3) L: Jeff Robinson (2-3) S: John Franco (1) | Sixth | 8 out |
| » Lost to Reds (10-13), 7-3 | Riverfront Stadium (0-4) | 7-15 | Lost 7 |
| » W: Bob Owchinko (1-0) L: Mike Krukow (1-4) | Sixth | 8 out |
| Monday, April 30 |
| » Lost to Dodgers (17-8), 1-0 | Candlestick Park (6-7) | 7-16 | Lost 8 |
| » W: Fernando Valenzuela (3-2) L: Bill Laskey (0-3) | Sixth | 9 out |
| Tuesday, May 1 |
| » Lost to Dodgers (18-8), 3-2 | Candlestick Park (6-8) | 7-17 | Lost 9 |
| » W: Orel Hershiser (2-0) L: Gary Lavelle (1-1) S: Carlos Diaz (1) | Sixth | 10 out |
| Wednesday, May 2 |
| » Defeated Dodgers (18-9), 4-3 | Candlestick Park (7-8) | 8-17 | |
| » W: Gary Lavelle (2-1) L: Tom Niedenfuer (0-2) | Sixth | 9 out |
| Friday, May 4 |
| » Defeated Cardinals (13-13), 2-0 | Busch Stadium II (1-0) | 9-17 | Won 2 |
| » W: Jeff Robinson (3-3) L: Danny Cox (2-3) S: Gary Lavelle (4) | Fifth | 8½ out |
| Saturday, May 5 |
| » Defeated Cardinals (13-14), 7-0 | Busch Stadium II (2-0) | 10-17 | Won 3 |
| » W: Frank Williams (1-0) L: Bob Forsch (0-3) | Fifth | 7½ out |
| Sunday, May 6 |
| » Defeated Cardinals (13-15), 3-2 | Busch Stadium II (3-0) | 11-17 | Won 4 |
| » W: Bill Laskey (1-3) L: Joaquin Andujar (4-3) S: Gary Lavelle (5) | Fifth | 7 out |
| Monday, May 7 |
| » Lost to Cubs (15-11), 10-7 | Wrigley Field (0-1) | 11-18 | |
| » W: Chuck Rainey (2-3) L: Mark Davis (0-4) S: Tim Stoddard (1) | Fifth | 7 out |
| Tuesday, May 8 |
| » Lost to Cubs (16-11), 12-11 | Wrigley Field (0-2) | 11-19 | Lost 2 |
| » W: Lee Smith (3-2) L: Greg Minton (1-2) | Fifth | 8 out |
| Thursday, May 10 |
| » Lost to Pirates (10-16), 4-2 | Three Rivers Stadium (0-1) | 11-20 | Lost 3 |
| » W: Rick Rhoden (3-3) L: Jeff Robinson (3-4) S: Kent Tekulve (3) | Sixth | 8½ out |
| Friday, May 11 |
| » Lost to Expos (16-15), 7-5 | Candlestick Park (7-9) | 11-21 | Lost 4 |
| » W: Charlie Lea (5-2) L: Bill Laskey (1-4) S: Jeff Reardon (5) | Sixth | 8½ out |
| Saturday, May 12 |
| » Defeated Expos (16-16), 8-7 | Candlestick Park (8-9) | 12-21 | |
| » W: Mike Krukow (2-4) L: Steve Rogers (2-2) S: Frank Williams (2) | Sixth | 7½ out |
| Sunday, May 13 |
| » Defeated Expos (16-17), 4-3 | Candlestick Park (9-9) | 13-21 | Won 2 |
| » W: Scott Garrelts (1-0) L: Andy McGaffigan (2-1) S: Randy Lerch (1) | Fifth | 7½ out |
| Tuesday, May 15 |
| » Lost to Mets (19-13), 7-6 | Candlestick Park (9-10) | 13-22 | |
| » W: Jesse Orosco (3-1) L: Mark Davis (0-5) S: Doug Sisk (4) | Sixth | 7 out |
| Wednesday, May 16 |
| » Defeated Mets (19-14), 4-3 | Candlestick Park (10-10) | 14-22 | |
| » W: Mark Davis (1-5) L: Walt Terrell (3-3) | Sixth | 6 out |
| Friday, May 18 |
| » Lost to Phillies (20-16), 1-0 | Candlestick Park (10-11) | 14-23 | |
| » W: Marty Bystrom (1-1) L: Mike Krukow (2-5) S: Al Holland (8) | Fifth | 6 out |
| Saturday, May 19 |
| » Lost to Phillies (21-16), 6-2 | Candlestick Park (10-12) | 14-24 | Lost 2 |
| » W: John Denny (4-3) L: Renie Martin (1-1) S: Al Holland (9) | Sixth | 7 out |
| Sunday, May 20 |
| » Lost to Phillies (22-16), 7-4 | Candlestick Park (10-13) | 14-25 | Lost 3 |
| » W: Charles Hudson (5-2) L: Jeff Robinson (3-5) S: Larry Andersen (1) | Sixth | 8 out |
| Tuesday, May 22 |
| » Defeated Mets (20-17), 5-4 | Shea Stadium (1-0) | 15-25 | |
| » W: Mark Davis (2-5) L: Ron Darling (3-3) S: Gary Lavelle (6) | Fifth | 7 out |
| Thursday, May 24 |
| » Defeated Mets (20-18), 3-2 | Shea Stadium (2-0) | 16-25 | Won 2 |
| » W: Mike Krukow (3-5) L: Walt Terrell (3-4) | Sixth | 6½ out |
| Friday, May 25 |
| » Lost to Expos (22-21), 3-2 | Stade Olympique (0-1) | 16-26 | |
| » W: Jeff Reardon (2-1) L: Greg Minton (1-3) | Sixth | 6½ out |
| Saturday, May 26 |
| » Lost to Expos (23-21), 4-2 | Stade Olympique (0-2) | 16-27 | Lost 2 |
| » W: Bill Gullickson (1-4) L: Bill Laskey (1-5) S: Jeff Reardon (7) | Fifth | 6½ out |
| Sunday, May 27 |
| » Lost to Expos (24-21), 6-2 | Stade Olympique (0-3) | 16-28 | Lost 3 |
| » W: Charlie Lea (8-2) L: Mark Grant (0-2) | Sixth | 7½ out |
| Wednesday, May 30 |
| » Lost to Phillies (26-19), 3-2 | Veteran's Stadium (0-1) | 16-29 | Lost 4 |
| » W: Al Holland (3-2) L: Greg Minton (1-4) | Sixth | 9 out |
| Friday, June 1 |
| » Defeated Padres (25-22), 11-7 | Candlestick Park (11-13) | 17-29 | |
| » W: Frank Williams (2-0) L: Andy Hawkins (3-2) S: Greg Minton (2) | Sixth | 9 out |
| Saturday, June 2 |
| » Lost to Padres (26-22), 3-2 | Candlestick Park (11-14) | 17-30 | |
| » W: Rich Gossage (2-1) L: Scott Garrelts (1-1) | Sixth | 9½ out |
| Sunday, June 3 |
| » Lost to Padres (27-22), 7-5 | Candlestick Park (11-15) | 17-31 | Lost 2 |
| » W: Tim Lollar (4-4) L: Jeff Cornell (0-1) S: Dave Dravecky (4) | Sixth | 11 out |
| » Lost to Padres (28-22), 7-6 | Candlestick Park (11-16) | 17-32 | Lost 3 |
| » W: Eric Show (7-3) L: Gary Lavelle (2-2) S: Rich Gossage (12) | Sixth | 11 out |
| Monday, June 4 |
| » Lost to Braves (31-23), 2-1 | Candlestick Park (11-17) | 17-33 | Lost 4 |
| » W: Rick Mahler (4-1) L: Mark Davis (2-6) S: Steve Bedrosian (8) | Sixth | 12 out |
| Tuesday, June 5 |
| » Lost to Braves (32-23), 8-3 | Candlestick Park (11-18) | 17-34 | Lost 5 |
| » W: Craig McMurtry (5-6) L: Mike Krukow (3-6) S: Gene Garber (3) | Sixth | 13 out |
| Wednesday, June 6 |
| » Lost to Braves (33-23), 5-4 | Candlestick Park (11-19) | 17-35 | Lost 6 |
| » W: Steve Bedrosian (4-1) L: Gary Lavelle (2-3) | Sixth | 14 out |
| Thursday, June 7 |
| » Lost to Astros (23-32), 14-5 | Candlestick Park (11-20) | 17-36 | Lost 7 |
| » W: Joe Niekro (4-7) L: Bill Laskey (1-6) | Sixth | 15 out |
| Friday, June 8 |
| » Defeated Astros (23-33), 5-4 | Candlestick Park (12-20) | 18-36 | |
| » W: Randy Lerch (2-1) L: Bob Knepper (6-6) S: Greg Minton (3) | Sixth | 14 out |
| Saturday, June 9 |
| » Defeated Astros (23-34), 6-5 | Candlestick Park (13-20) | 19-36 | Won 2 |
| » W: Frank Williams (3-0) L: Bill Dawley (3-4) | Sixth | 13½ out |
| Sunday, June 10 |
| » Lost to Astros (24-34), 7-4 | Candlestick Park (13-21) | 19-37 | |
| » W: Vern Ruhle (1-4) L: Jeff Robinson (3-6) | Sixth | 14½ out |
| Monday, June 11 |
| » Defeated Dodgers (34-28), 8-4 | Dodger Stadium (2-2) | 20-37 | |
| » W: Bill Laskey (2-6) L: Rick Honeycutt (7-3) | Sixth | 14½ out |
| Tuesday, June 12 |
| » Lost to Dodgers (35-28), 8-7 | Dodger Stadium (2-3) | 20-38 | |
| » W: Pat Zachry (4-1) L: Greg Minton (1-5) | Sixth | 15½ out |
| Wednesday, June 13 |
| » Defeated Dodgers (35-29), 10-5 | Dodger Stadium (3-3) | 21-38 | |
| » W: Jeff Cornell (1-1) L: Burt Hooton (0-2) S: Randy Lerch (2) | Sixth | 15 out |
| Thursday, June 14 |
| » Defeated Padres (36-24), 5-2 | San Diego/Jack Murphy Stadium (1-3) | 22-38 | Won 2 |
| » W: Mark Davis (3-6) L: Tim Lollar (5-5) S: Gary Lavelle (7) | Sixth | 14 out |
| Friday, June 15 |
| » Lost to Padres (37-24), 3-2 | San Diego/Jack Murphy Stadium (1-4) | 22-39 | |
| » W: Ed Whitson (7-3) L: Jeff Robinson (3-7) S: Rich Gossage (13) | Sixth | 15 out |
| Saturday, June 16 |
| » Defeated Padres (37-25), 6-3 | San Diego/Jack Murphy Stadium (2-4) | 23-39 | |
| » W: Bill Laskey (3-6) L: Andy Hawkins (4-3) S: Greg Minton (4) | Sixth | 14 out |
| Sunday, June 17 |
| » Defeated Padres (37-26), 5-3 | San Diego/Jack Murphy Stadium (3-4) | 24-39 | Won 2 |
| » W: Frank Williams (4-0) L: Craig Lefferts (1-3) | Sixth | 13 out |
| Former Giant Jim Hegan dies in Swampscott, MA at the age of 64. |
| Tuesday, June 19 |
| » Lost to Braves (38-29), 11-6 | Atlanta-Fulton County Stadium (0-1) | 24-40 | |
| » W: Rick Camp (3-0) L: Jeff Cornell (1-2) | Sixth | 14 out |
| Wednesday, June 20 |
| » Lost to Braves (39-29), 6-5 | Atlanta-Fulton County Stadium (0-2) | 24-41 | Lost 2 |
| » W: Len Barker (6-6) L: Jeff Robinson (3-8) S: Terry Forster (5) | Sixth | 15 out |
| Thursday, June 21 |
| » Defeated Braves (39-30), 5-3 | Atlanta-Fulton County Stadium (1-2) | 25-41 | |
| » W: Bill Laskey (4-6) L: Rick Mahler (5-2) S: Greg Minton (5) | Sixth | 14 out |
| Friday, June 22 |
| » Lost to Astros (32-37), 10-3 | Astrodome (0-1) | 25-42 | |
| » W: Mike Scott (4-4) L: Mike Krukow (3-7) | Sixth | 14 out |
| Saturday, June 23 |
| » Defeated Astros (32-38), 7-5 | Astrodome (1-1) | 26-42 | |
| » W: Frank Williams (5-0) L: Vern Ruhle (1-5) S: Greg Minton (6) | Sixth | 14 out |
| Sunday, June 24 |
| » Lost to Astros (33-38), 8-3 | Astrodome (1-2) | 26-43 | |
| » W: Bob Knepper (7-7) L: Jeff Robinson (3-9) | Sixth | 15 out |
| Monday, June 25 |
| » Lost to Reds (34-40), 2-1 | Candlestick Park (13-22) | 26-44 | Lost 2 |
| » W: Ted Power (4-4) L: Bill Laskey (4-7) | Sixth | 16 out |
| Tuesday, June 26 |
| » Lost to Reds (35-40), 4-2 | Candlestick Park (13-23) | 26-45 | Lost 3 |
| » W: Mario Soto (8-1) L: Frank Williams (5-1) | Sixth | 17 out |
| Wednesday, June 27 |
| » Defeated Reds (35-41), 14-9 | Candlestick Park (14-23) | 27-45 | |
| » W: Randy Lerch (3-1) L: Bob Owchinko (3-4) | Sixth | 16 out |
| Thursday, June 28 |
| » Defeated Pirates (30-44), 4-3 | Candlestick Park (15-23) | 28-45 | Won 2 |
| » W: Gary Lavelle (3-3) L: Don Robinson (0-3) | Sixth | 16 out |
| Friday, June 29 |
| » Defeated Pirates (30-45), 3-0 | Candlestick Park (16-23) | 29-45 | Won 3 |
| » W: Jeff Robinson (4-9) L: John Tudor (4-6) | Sixth | 15 out |
| Saturday, June 30 |
| » Defeated Pirates (30-46), 7-5 | Candlestick Park (17-23) | 30-45 | Won 4 |
| » W: Frank Williams (6-1) L: Cecilio Guante (2-3) S: Gary Lavelle (8) | Sixth | 14 out |
| Sunday, July 1 |
| » Defeated Pirates (30-47), 7-4 | Candlestick Park (18-23) | 31-45 | Won 5 |
| » W: Atlee Hammaker (1-0) L: Rick Rhoden (6-6) S: Greg Minton (7) | Sixth | 14 out |
| Tuesday, July 3 |
| » Defeated Cardinals (38-42), 6-2 | Candlestick Park (19-23) | 32-45 | Won 6 |
| » W: Mike Krukow (4-7) L: Neil Allen (3-2) | Fifth | 13½ out |
| Wednesday, July 4 |
| » Lost to Cardinals (39-42), 4-3 | Candlestick Park (19-24) | 32-46 | |
| » W: Ricky Horton (5-1) L: Mark Davis (3-7) S: Bruce Sutter (20) | Fifth | 14 out |
| » Lost to Cardinals (40-42), 5-1 | Candlestick Park (19-25) | 32-47 | Lost 2 |
| » W: Kurt Kepshire (1-0) L: Jeff Robinson (4-10) S: Jeff Lahti (1) | Fifth | 14 out |
| » Major-league debuts: Kurt Kepshire (Cardinals) |
| Thursday, July 5 |
| » Lost to Cubs (46-35), 9-3 | Candlestick Park (19-26) | 32-48 | Lost 3 |
| » W: Scott Sanderson (5-1) L: Bill Laskey (4-8) S: Rich Bordi (3) | Sixth | 15 out |
| Friday, July 6 |
| » Lost to Cubs (47-35), 5-4 | Candlestick Park (19-27) | 32-49 | Lost 4 |
| » W: Tim Stoddard (6-1) L: Greg Minton (1-6) S: Lee Smith (17) | Sixth | 16 out |
| Saturday, July 7 |
| » Defeated Cubs (47-36), 7-2 | Candlestick Park (20-27) | 33-49 | |
| » W: Mike Krukow (5-7) L: Rick Reuschel (4-5) | Sixth | 16 out |
| Sunday, July 8 |
| » Lost to Cubs (48-36), 6-3 | Candlestick Park (20-28) | 33-50 | |
| » W: Rick Sutcliffe (8-6) L: Mark Davis (3-8) S: Lee Smith (18) | Sixth | 16 out |
| Thursday, July 12 |
| » Lost to Pirates (33-52), 6-3 | Three Rivers Stadium (0-2) | 33-51 | Lost 2 |
| » W: Jose DeLeon (6-4) L: Bill Laskey (4-9) S: Kent Tekulve (8) | Sixth | 17 out |
| Friday, July 13 |
| » Lost to Pirates (34-52), 8-2 | Three Rivers Stadium (0-3) | 33-52 | Lost 3 |
| » W: John Candelaria (8-6) L: Mike Krukow (5-8) | Sixth | 17½ out |
| » Lost to Pirates (35-52), 4-3 | Three Rivers Stadium (0-4) | 33-53 | Lost 4 |
| » W: Rod Scurry (2-5) L: Jeff Cornell (1-3) | Sixth | 17½ out |
| Saturday, July 14 |
| » Lost to Pirates (36-52), 6-2 | Three Rivers Stadium (0-5) | 33-54 | Lost 5 |
| » W: Rick Rhoden (7-7) L: Mark Davis (3-9) | Sixth | 17½ out |
| Sunday, July 15 |
| » Lost to Pirates (37-52), 9-3 | Three Rivers Stadium (0-6) | 33-55 | Lost 6 |
| » W: John Tudor (5-7) L: Jeff Robinson (4-11) | Sixth | 18½ out |
| Monday, July 16 |
| » Defeated Cardinals (44-47), 7-6 | Busch Stadium II (4-0) | 34-55 | |
| » W: Bill Laskey (5-9) L: Rick Ownbey (0-2) S: Greg Minton (8) | Sixth | 18½ out |
| Tuesday, July 17 |
| » Defeated Cardinals (44-48), 7-2 | Busch Stadium II (5-0) | 35-55 | Won 2 |
| » W: Mike Krukow (6-8) L: Joaquin Andujar (13-8) S: Greg Minton (9) | Sixth | 18½ out |
| Wednesday, July 18 |
| » Lost to Cardinals (45-48), 8-4 | Busch Stadium II (5-1) | 35-56 | |
| » W: Dave VonOhlen (1-0) L: Bob Lacey (0-1) | Sixth | 18½ out |
| » Major-league debuts: Terry Pendleton (Cardinals) |
| Thursday, July 19 |
| » Lost to Cubs (53-39), 6-4 | Wrigley Field (0-3) | 35-57 | Lost 2 |
| » W: George Frazier (5-2) L: Mark Davis (3-10) S: Tim Stoddard (6) | Sixth | 18½ out |
| Friday, July 20 |
| » Defeated Cubs (53-40), 3-2 | Wrigley Field (1-3) | 36-57 | |
| » W: Jeff Robinson (5-11) L: Dennis Eckersley (7-10) S: Greg Minton (10) | Sixth | 18 out |
| Saturday, July 21 |
| » Lost to Cubs (54-40), 4-3 | Wrigley Field (1-4) | 36-58 | |
| » W: Rich Bordi (4-1) L: Greg Minton (1-7) | Sixth | 19 out |
| Sunday, July 22 |
| » Defeated Cubs (54-41), 11-5 | Wrigley Field (2-4) | 37-58 | |
| » W: Mike Krukow (7-8) L: Steve Trout (9-5) | Sixth | 18½ out |
| Tuesday, July 24 |
| » Lost to Astros (48-51), 10-3 | Candlestick Park (20-29) | 37-59 | |
| » W: Nolan Ryan (8-6) L: Mark Davis (3-11) | Sixth | 18½ out |
| Wednesday, July 25 |
| » Defeated Astros (48-52), 7-3 | Candlestick Park (21-29) | 38-59 | |
| » W: Jeff Robinson (6-11) L: Mike LaCoss (5-1) | Sixth | 18½ out |
| Thursday, July 26 |
| » Defeated Astros (48-53), 3-2 | Candlestick Park (22-29) | 39-59 | Won 2 |
| » W: Bill Laskey (6-9) L: Mike Scott (4-9) S: Frank Williams (3) | Sixth | 18½ out |
| Friday, July 27 |
| » Defeated Braves (52-50), 6-0 | Candlestick Park (23-29) | 40-59 | Won 3 |
| » W: Mike Krukow (8-8) L: Rick Camp (5-3) | Sixth | 18½ out |
| Saturday, July 28 |
| » Lost to Braves (53-50), 4-3 | Candlestick Park (23-30) | 40-60 | |
| » W: Rick Mahler (7-6) L: Mark Davis (3-12) S: Donnie Moore (12) | Sixth | 19 out |
| Sunday, July 29 |
| » Lost to Braves (54-50), 4-3 | Candlestick Park (23-31) | 40-61 | Lost 2 |
| » W: Pascual Perez (10-4) L: Mark Calvert (0-1) S: Gene Garber (4) | Sixth | 20 out |
| Tuesday, July 31 |
| » Lost to Reds (44-61), 3-0 | Riverfront Stadium (0-5) | 40-62 | Lost 3 |
| » W: Jay Tibbs (2-0) L: Jeff Robinson (6-12) | Sixth | 21½ out |
| Wednesday, August 1 |
| » Lost to Reds (45-61), 6-3 | Riverfront Stadium (0-6) | 40-63 | Lost 4 |
| » W: Joe Price (5-7) L: Gary Lavelle (3-4) | Sixth | 22½ out |
| Thursday, August 2 |
| » Defeated Reds (45-62), 5-2 | Riverfront Stadium (1-6) | 41-63 | |
| » W: Mike Krukow (9-8) L: Frank Pastore (3-6) S: Greg Minton (11) | Sixth | 22 out |
| Friday, August 3 |
| » Lost to Braves (57-51), 2-1 | Atlanta-Fulton County Stadium (1-3) | 41-64 | |
| » W: Donnie Moore (2-2) L: Greg Minton (1-8) | Sixth | 22 out |
| Saturday, August 4 |
| » Defeated Braves (57-52), 9-2 | Atlanta-Fulton County Stadium (2-3) | 42-64 | |
| » W: Mark Calvert (1-1) L: Craig McMurtry (8-12) | Sixth | 22 out |
| Sunday, August 5 |
| » Defeated Braves (57-53), 7-4 | Atlanta-Fulton County Stadium (3-3) | 43-64 | Won 2 |
| » Manager: Danny Ozark |
| » W: Gary Lavelle (4-4) L: Gene Garber (1-2) S: Greg Minton (12) | Sixth | 22 out |
| Monday, August 6 |
| » Lost to Astros (52-60), 8-0 | Astrodome (1-3) | 43-65 | |
| » W: Bob Knepper (10-8) L: Bill Laskey (6-10) | Sixth | 23 out |
| Tuesday, August 7 |
| » Defeated Astros (52-61), 9-2 | Astrodome (2-3) | 44-65 | |
| » W: Mike Krukow (10-8) L: Mike Scott (4-10) | Sixth | 22 out |
| Wednesday, August 8 |
| » Lost to Astros (53-61), 7-6 | Astrodome (2-4) | 44-66 | |
| » W: Bill Dawley (6-4) L: Mark Calvert (1-2) | Sixth | 22 out |
| Thursday, August 9 |
| » Lost to Astros (54-61), 6-0 | Astrodome (2-5) | 44-67 | Lost 2 |
| » W: Mike LaCoss (6-3) L: Jeff Robinson (6-13) | Sixth | 22 out |
| Friday, August 10 |
| » Defeated Dodgers (57-59), 4-1 | Candlestick Park (24-31) | 45-67 | |
| » W: Mark Calvert (2-2) L: Fernando Valenzuela (9-13) | Sixth | 21½ out |
| Saturday, August 11 |
| » Lost to Dodgers (58-59), 4-2 | Candlestick Park (24-32) | 45-68 | |
| » W: Rick Honeycutt (9-7) L: Bill Laskey (6-11) S: Ken Howell (2) | Sixth | 22½ out |
| Sunday, August 12 |
| » Lost to Dodgers (59-59), 5-4 | Candlestick Park (24-33) | 45-69 | Lost 2 |
| » W: Alejandro Pena (12-6) L: Mark Davis (3-13) | Sixth | 22½ out |
| Tuesday, August 14 |
| » Lost to Expos (57-60), 7-6 | Candlestick Park (24-34) | 45-70 | Lost 3 |
| » W: Bill Gullickson (8-7) L: Mark Davis (3-14) S: Jeff Reardon (16) | Sixth | 23½ out |
| Former Giant Lynn McGlothen dies in Dubach, LA at the age of 35. |
| Wednesday, August 15 |
| » Lost to Expos (58-60), 8-3 | Candlestick Park (24-35) | 45-71 | Lost 4 |
| » W: Dan Schatzeder (6-3) L: Mark Calvert (2-3) | Sixth | 24½ out |
| Thursday, August 16 |
| » Lost to Expos (59-60), 11-3 | Candlestick Park (24-36) | 45-72 | Lost 5 |
| » W: Charlie Lea (15-8) L: Bob Lacey (0-2) | Sixth | 24½ out |
| Friday, August 17 |
| » Lost to Mets (67-51), 2-0 | Candlestick Park (24-37) | 45-73 | Lost 6 |
| » W: Dwight Gooden (11-8) L: Mike Krukow (10-9) S: Jesse Orosco (26) | Sixth | 24½ out |
| Saturday, August 18 |
| » Defeated Mets (67-52), 6-5 | Candlestick Park (25-37) | 46-73 | |
| » W: Randy Lerch (4-1) L: Brent Gaff (1-2) | Sixth | 24 out |
| Sunday, August 19 |
| » Defeated Mets (67-53), 7-6 | Candlestick Park (26-37) | 47-73 | Won 2 |
| » W: Gary Lavelle (5-4) L: Jesse Orosco (8-4) | Sixth | 23½ out |
| » Lost to Mets (68-53), 4-2 | Candlestick Park (26-38) | 47-74 | |
| » W: Bruce Berenyi (9-12) L: Mark Davis (3-15) S: Jesse Orosco (27) | Sixth | 23½ out |
| Monday, August 20 |
| » Lost to Phillies (66-56), 6-4 | Candlestick Park (26-39) | 47-75 | Lost 2 |
| » W: John Denny (6-3) L: Mark Calvert (2-4) S: Al Holland (27) | Sixth | 24½ out |
| Tuesday, August 21 |
| » Lost to Phillies (67-56), 12-5 | Candlestick Park (26-40) | 47-76 | Lost 3 |
| » W: Kevin Gross (7-5) L: Frank Williams (6-2) | Sixth | 25½ out |
| Wednesday, August 22 |
| » Defeated Phillies (67-57), 7-5 | Candlestick Park (27-40) | 48-76 | |
| » W: Mark Davis (4-15) L: Al Holland (5-8) S: Gary Lavelle (9) | Sixth | 24½ out |
| Friday, August 24 |
| » Defeated Mets (69-56), 7-6 | Shea Stadium (3-0) | 49-76 | Won 2 |
| » W: Frank Williams (7-2) L: Jesse Orosco (8-5) S: Greg Minton (13) | Sixth | 23½ out |
| » Defeated Mets (69-57), 6-5 | Shea Stadium (4-0) | 50-76 | Won 3 |
| » W: Frank Williams (8-2) L: Walt Terrell (9-10) S: Greg Minton (14) | Sixth | 23½ out |
| Saturday, August 25 |
| » Defeated Mets (69-58), 5-4 | Shea Stadium (5-0) | 51-76 | Won 4 |
| » W: Randy Lerch (5-1) L: Bruce Berenyi (9-13) S: Gary Lavelle (10) | Sixth | 23½ out |
| Former Giant Waite Hoyt dies in Cincinnati, OH at the age of 85. |
| Sunday, August 26 |
| » Lost to Mets (70-58), 11-6 | Shea Stadium (5-1) | 51-77 | |
| » W: Brent Gaff (2-2) L: Mike Krukow (10-10) | Sixth | 24½ out |
| Monday, August 27 |
| » Defeated Expos (64-65), 5-4 | Stade Olympique (1-3) | 52-77 | |
| » W: Frank Williams (9-2) L: Jeff Reardon (5-7) | Sixth | 23½ out |
| Tuesday, August 28 |
| » Defeated Expos (64-66), 3-2 | Stade Olympique (2-3) | 53-77 | Won 2 |
| » W: Jeff Robinson (7-13) L: Bryn Smith (9-11) S: Greg Minton (15) | Sixth | 22½ out |
| Wednesday, August 29 |
| » Defeated Expos (64-67), 4-3 | Stade Olympique (3-3) | 54-77 | Won 3 |
| » W: Greg Minton (2-8) L: Rick Grapenthin (0-2) | Fifth | 22½ out |
| Thursday, August 30 |
| » Defeated Phillies (71-60), 6-5 | Veteran's Stadium (1-1) | 55-77 | Won 4 |
| » W: Bob Lacey (1-2) L: Al Holland (5-9) S: Greg Minton (16) | Fifth | 22½ out |
| » Lost to Phillies (72-60), 6-5 | Veteran's Stadium (1-2) | 55-78 | |
| » W: Larry Andersen (2-3) L: Mark Davis (4-16) | Fifth | 22½ out |
| Friday, August 31 |
| » Defeated Phillies (72-61), 6-5 | Veteran's Stadium (2-2) | 56-78 | |
| » W: Bill Laskey (7-11) L: Jerry Koosman (14-11) S: Mike Krukow (1) | Fifth | 22 out |
| Saturday, September 1 |
| » Defeated Phillies (72-62), 7-2 | Veteran's Stadium (3-2) | 57-78 | Won 2 |
| » W: Atlee Hammaker (2-0) L: Charles Hudson (8-10) S: Mark Grant (1) | Fifth | 20½ out |
| » Major-league debuts: Rick Schu (Phillies) |
| Sunday, September 2 |
| » Lost to Phillies (73-62), 8-3 | Veteran's Stadium (3-3) | 57-79 | |
| » W: Shane Rawley (10-6) L: Jeff Robinson (7-14) | Fifth | 20½ out |
| Monday, September 3 |
| » Defeated Reds (57-81), 4-3 | Candlestick Park (28-40) | 58-79 | |
| » W: Greg Minton (3-8) L: Jeff Russell (6-16) | Fifth | 20½ out |
| » Major-league debuts: Chris Brown (Giants) |
| Tuesday, September 4 |
| » Lost to Reds (58-81), 8-3 | Candlestick Park (28-41) | 58-80 | |
| » W: Mario Soto (14-7) L: Greg Minton (3-9) | Fifth | 20½ out |
| » Major-league debuts: Rob Deer (Giants) |
| Wednesday, September 5 |
| » Lost to Astros (70-70), 4-1 | Candlestick Park (28-42) | 58-81 | Lost 2 |
| » W: Nolan Ryan (12-9) L: Randy Lerch (5-2) S: Bill Dawley (4) | Fifth | 21½ out |
| Thursday, September 6 |
| » Lost to Astros (71-70), 14-2 | Candlestick Park (28-43) | 58-82 | Lost 3 |
| » W: Bob Knepper (14-9) L: Bill Laskey (7-12) | Sixth | 21½ out |
| Friday, September 7 |
| » Defeated Braves (69-72), 5-4 | Candlestick Park (29-43) | 59-82 | |
| » W: Mark Grant (1-2) L: Gene Garber (2-5) S: Greg Minton (17) | Sixth | 20½ out |
| Saturday, September 8 |
| » Defeated Braves (69-73), 4-0 | Candlestick Park (30-43) | 60-82 | Won 2 |
| » W: Bill Laskey (8-12) L: Craig McMurtry (9-15) | Fifth | 20 out |
| Sunday, September 9 |
| » Defeated Braves (69-74), 6-4 | Candlestick Park (31-43) | 61-82 | Won 3 |
| » W: Mark Davis (5-16) L: Tony Brizzolara (1-2) S: Greg Minton (18) | Fifth | 20 out |
| Tuesday, September 11 |
| » Lost to Reds (62-83), 7-3 | Riverfront Stadium (1-7) | 61-83 | |
| » W: Mario Soto (15-7) L: Randy Lerch (5-3) | Sixth | 20 out |
| Wednesday, September 12 |
| » Lost to Reds (63-83), 7-4 | Riverfront Stadium (1-8) | 61-84 | Lost 2 |
| » W: Jay Tibbs (4-2) L: Mark Grant (1-3) S: Ted Power (8) | Fifth | 20 out |
| Thursday, September 13 |
| » Major-league debuts: John Christensen (Mets) |
| Friday, September 14 |
| » Defeated Braves (72-75), 3-0 | Atlanta-Fulton County Stadium (4-3) | 62-84 | |
| » W: Greg Minton (4-9) L: Donnie Moore (4-4) | Fifth | 20 out |
| Saturday, September 15 |
| » Lost to Braves (73-75), 4-1 | Atlanta-Fulton County Stadium (4-4) | 62-85 | |
| » W: Rick Camp (7-6) L: Mike Krukow (10-11) | Fifth | 20 out |
| Sunday, September 16 |
| » Lost to Braves (74-75), 7-5 | Atlanta-Fulton County Stadium (4-5) | 62-86 | Lost 2 |
| » W: Rick Mahler (11-9) L: Bill Laskey (8-13) S: Gene Garber (9) | Fifth | 20 out |
| Monday, September 17 |
| » Lost to Astros (75-75), 5-3 | Astrodome (2-6) | 62-87 | Lost 3 |
| » W: Joe Niekro (15-10) L: Mark Grant (1-4) S: Bill Dawley (5) | Sixth | 21 out |
| Tuesday, September 18 |
| » Lost to Astros (76-75), 5-4 | Astrodome (2-7) | 62-88 | Lost 4 |
| » W: Dave Smith (5-3) L: Scott Garrelts (1-2) | Sixth | 22 out |
| Wednesday, September 19 |
| » Lost to Padres (85-66), 5-4 | San Diego/Jack Murphy Stadium (3-5) | 62-89 | Lost 5 |
| » W: Andy Hawkins (8-9) L: Scott Garrelts (1-3) | Sixth | |
