| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Tuesday, April 3 |
| » Lost to Athletics (1-0), 6-5 | Oakland-Alameda County Stadium (0-1) | 0-1 | |
| » W: Tom Burgmeier (1-0) L: Rollie Fingers (0-1) | Third | 1 out |
| Wednesday, April 4 |
| » Lost to Athletics (2-0), 4-3 | Oakland-Alameda County Stadium (0-2) | 0-2 | Lost 2 |
| » W: Ray Burris (1-0) L: Mike Caldwell (0-1) S: Bill Caudill (1) | Fourth | 1½ out |
| Thursday, April 5 |
| » Major-league debuts: Jeff Reed (Twins) |
| Friday, April 6 |
| » Lost to Mariners (2-1), 6-3 | Kingdome (0-1) | 0-3 | Lost 3 |
| » W: Matt Young (1-0) L: Moose Haas (0-1) S: Ed Vande Berg (1) | Sixth | 3 out |
| Saturday, April 7 |
| » Lost to Mariners (3-1), 3-2 | Kingdome (0-2) | 0-4 | Lost 4 |
| » W: Mark Langston (1-0) L: Tom Tellmann (0-1) S: Ed Vande Berg (2) | Seventh | 4 out |
| » Major-league debuts: Mark Langston (Mariners) |
| Sunday, April 8 |
| » Lost to Mariners (4-1), 5-4 | Kingdome (0-3) | 0-5 | Lost 5 |
| » W: Mike Moore (1-0) L: Don Sutton (0-1) S: Dave Beard (1) | Seventh | 5 out |
| Tuesday, April 10 |
| » Defeated Angels (2-5), 10-1 | Anaheim Stadium (1-0) | 1-5 | |
| » W: Mike Caldwell (1-1) L: Mike Witt (0-1) | Sixth | 5 out |
| Wednesday, April 11 |
| » Lost to Angels (3-5), 9-5 | Anaheim Stadium (1-1) | 1-6 | |
| » W: Ron Romanick (1-0) L: Moose Haas (0-2) | Seventh | 5½ out |
| Friday, April 13 |
| » Lost to Royals (5-3), 6-3 | Royals Stadium (0-1) | 1-7 | Lost 2 |
| » W: Bud Black (3-0) L: Jaime Cocanower (0-1) S: Dan Quisenberry (4) | Sixth | 7 out |
| Saturday, April 14 |
| » Defeated Royals (5-4), 8-4 | Royals Stadium (1-1) | 2-7 | |
| » W: Don Sutton (1-1) L: Mark Huismann (0-1) S: Rollie Fingers (1) | Fifth | 6½ out |
| Sunday, April 15 |
| » Defeated Royals (5-5), 3-2 | Royals Stadium (2-1) | 3-7 | Won 2 |
| » W: Mike Caldwell (2-1) L: Dan Quisenberry (0-1) S: Rollie Fingers (2) | Sixth | 6 out |
| Tuesday, April 17 |
| » Defeated White Sox (4-5), 7-3 | County Stadium (1-0) | 4-7 | Won 3 |
| » W: Moose Haas (1-2) L: Tom Seaver (0-2) S: Pete Ladd (1) | Fifth | 5½ out |
| Thursday, April 19 |
| » Lost to White Sox (5-5), 3-1 | County Stadium (1-1) | 4-8 | |
| » W: Richard Dotson (2-1) L: Jaime Cocanower (0-2) | Fifth | 6 out |
| Friday, April 20 |
| » Lost to Mariners (9-5), 5-0 | County Stadium (1-2) | 4-9 | Lost 2 |
| » W: Jim Beattie (2-1) L: Don Sutton (1-2) | Fifth | 7 out |
| Saturday, April 21 |
| » Defeated Mariners (9-6), 6-2 | County Stadium (2-2) | 5-9 | |
| » W: Mike Caldwell (3-1) L: Matt Young (2-2) | Fifth | 7 out |
| Tuesday, April 24 |
| » Defeated Athletics (10-8), 3-2 | County Stadium (3-2) | 6-9 | Won 2 |
| » W: Pete Ladd (1-0) L: Lary Sorensen (1-3) | Fifth | 8 out |
| Wednesday, April 25 |
| » Lost to Angels (12-9), 5-1 | County Stadium (3-3) | 6-10 | |
| » W: Mike Witt (2-1) L: Jaime Cocanower (0-3) | Sixth | 9 out |
| Thursday, April 26 |
| » Defeated Angels (12-10), 2-1 | County Stadium (4-3) | 7-10 | |
| » W: Don Sutton (2-2) L: Tommy John (1-2) S: Rollie Fingers (3) | Fourth | 9 out |
| Friday, April 27 |
| » Defeated Yankees (7-11), 12-0 | Yankee Stadium (1-0) | 8-10 | Won 2 |
| » W: Mike Caldwell (4-1) L: Shane Rawley (0-2) | Fourth | 8 out |
| Saturday, April 28 |
| » Defeated Yankees (7-12), 8-0 | Yankee Stadium (2-0) | 9-10 | Won 3 |
| » W: Chuck Porter (1-0) L: John Montefusco (0-2) S: Bob McClure (1) | Fourth | 8 out |
| Sunday, April 29 |
| » Lost to Yankees (8-12), 6-5 | Yankee Stadium (2-1) | 9-11 | |
| » W: Jay Howell (1-1) L: Bob McClure (0-1) | Fourth | 9 out |
| Tuesday, May 1 |
| » Lost to Royals (9-11), 3-0 | County Stadium (4-4) | 9-12 | Lost 2 |
| » W: Larry Gura (4-0) L: Jaime Cocanower (0-4) S: Dan Quisenberry (7) | Fifth | 10 out |
| Thursday, May 3 |
| » Defeated Royals (9-12), 6-5 | County Stadium (5-4) | 10-12 | |
| » W: Tom Tellmann (1-1) L: Dan Quisenberry (1-2) | Fourth | 8½ out |
| Friday, May 4 |
| » Defeated Yankees (8-16), 1-0 | County Stadium (6-4) | 11-12 | Won 2 |
| » W: Chuck Porter (2-0) L: Phil Niekro (4-1) S: Rollie Fingers (4) | Fourth | 8½ out |
| Saturday, May 5 |
| » Defeated Yankees (8-17), 2-1 | County Stadium (7-4) | 12-12 | Won 3 |
| » W: Pete Ladd (2-0) L: Curt Brown (0-1) | Third | 8½ out |
| Sunday, May 6 |
| » Lost to Yankees (9-17), 8-4 | County Stadium (7-5) | 12-13 | |
| » W: Curt Brown (1-1) L: Pete Ladd (2-1) | Fourth | 9½ out |
| Monday, May 7 |
| » Defeated White Sox (12-15), 7-3 | Comiskey Park I (1-0) | 13-13 | |
| » W: Jaime Cocanower (1-4) L: La Marr Hoyt (3-3) | Third | 9½ out |
| Wednesday, May 9 |
| » Lost to White Sox (13-15), 7-6 | Comiskey Park I (1-1) | 13-14 | |
| » W: Tom Seaver (2-2) L: Chuck Porter (2-1) | Fourth | 11½ out |
| » Lost to White Sox (14-15), 5-4 | Comiskey Park I (1-2) | 13-15 | Lost 2 |
| » W: Tom Seaver (3-2) L: Mike Caldwell (4-2) S: Salome Barojas (1) | Fourth | 11½ out |
| Friday, May 11 |
| » Defeated Twins (18-16), 4-1 | County Stadium (8-5) | 14-15 | |
| » W: Moose Haas (2-2) L: Ed Hodge (1-1) S: Rollie Fingers (5) | Fourth | 11½ out |
| Saturday, May 12 |
| » Lost to Twins (19-16), 4-2 | County Stadium (8-6) | 14-16 | |
| » W: Mike Smithson (5-3) L: Mike Caldwell (4-3) S: Ron Davis (7) | Fourth | 11½ out |
| Sunday, May 13 |
| » Defeated Twins (19-17), 4-1 | County Stadium (9-6) | 15-16 | |
| » W: Jaime Cocanower (2-4) L: Frank Viola (3-4) S: Rollie Fingers (6) | Fourth | 11 out |
| Tuesday, May 15 |
| » Defeated Rangers (12-23), 3-2 | County Stadium (10-6) | 16-16 | Won 2 |
| » W: Don Sutton (3-2) L: Mike Mason (1-2) S: Rollie Fingers (7) | Fourth | 11½ out |
| Wednesday, May 16 |
| » Defeated Rangers (12-24), 5-1 | County Stadium (11-6) | 17-16 | Won 3 |
| » W: Chuck Porter (3-1) L: Danny Darwin (3-1) | Fourth | 11½ out |
| Thursday, May 17 |
| » Lost to Rangers (13-24), 4-1 | County Stadium (11-7) | 17-17 | |
| » W: Frank Tanana (4-4) L: Moose Haas (2-3) | Fourth | 12 out |
| Friday, May 18 |
| » Lost to Indians (14-19), 8-4 | County Stadium (11-8) | 17-18 | Lost 2 |
| » W: Mike Jeffcoat (1-0) L: Pete Ladd (2-2) | Fourth | 13 out |
| Saturday, May 19 |
| » Defeated Indians (14-20), 3-0 | County Stadium (12-8) | 18-18 | |
| » W: Jaime Cocanower (3-4) L: Dan Spillner (0-3) S: Rollie Fingers (8) | Fourth | 13 out |
| Sunday, May 20 |
| » Lost to Indians (15-20), 3-2 | County Stadium (12-9) | 18-19 | |
| » W: Ernie Camacho (1-3) L: Don Sutton (3-3) S: Tom Waddell (1) | Fourth | 14 out |
| Tuesday, May 22 |
| » Defeated Rangers (15-26), 7-1 | Arlington Stadium (1-0) | 19-19 | |
| » W: Chuck Porter (4-1) L: Danny Darwin (3-2) S: Rick Waits (1) | Fourth | 14 out |
| Wednesday, May 23 |
| » Lost to Rangers (16-26), 6-1 | Arlington Stadium (1-1) | 19-20 | |
| » W: Frank Tanana (5-4) L: Moose Haas (2-4) | Fourth | 15 out |
| Thursday, May 24 |
| » Lost to Rangers (17-26), 4-3 | Arlington Stadium (1-2) | 19-21 | Lost 2 |
| » W: Dave Stewart (3-6) L: Mike Caldwell (4-4) S: Dave Schmidt (2) | Fourth | 16 out |
| Friday, May 25 |
| » Lost to Twins (22-23), 7-4 | Hubert H. Humphrey Metrodome (0-1) | 19-22 | Lost 3 |
| » W: John Butcher (3-2) L: Jaime Cocanower (3-5) S: Ron Davis (8) | Fourth | 16 out |
| Saturday, May 26 |
| » Lost to Twins (23-23), 7-6 | Hubert H. Humphrey Metrodome (0-2) | 19-23 | Lost 4 |
| » W: Pete Filson (4-1) L: Rick Waits (0-1) | Fourth | 16 out |
| Sunday, May 27 |
| » Defeated Twins (23-24), 5-4 | Hubert H. Humphrey Metrodome (1-2) | 20-23 | |
| » W: Chuck Porter (5-1) L: Mike Smithson (6-5) S: Rollie Fingers (9) | Fourth | 15 out |
| Tuesday, May 29 |
| » Defeated Indians (16-27), 5-3 | Cleveland Stadium (1-0) | 21-23 | Won 2 |
| » W: Moose Haas (3-4) L: Dan Spillner (0-4) | Fourth | 14½ out |
| Wednesday, May 30 |
| » Lost to Indians (17-27), 9-1 | Cleveland Stadium (1-1) | 21-24 | |
| » W: Neal Heaton (3-4) L: Mike Caldwell (4-5) | Fourth | 15 out |
| » Defeated Indians (17-28), 3-2 | Cleveland Stadium (2-1) | 22-24 | |
| » W: Jaime Cocanower (4-5) L: Tom Waddell (2-2) S: Pete Ladd (2) | Fourth | 15 out |
| Friday, June 1 |
| » Lost to Red Sox (22-26), 3-1 | County Stadium (12-10) | 22-25 | |
| » W: Bruce Hurst (7-4) L: Don Sutton (3-4) | Fourth | 16 out |
| Saturday, June 2 |
| » Lost to Red Sox (23-26), 6-3 | County Stadium (12-11) | 22-26 | Lost 2 |
| » W: Roger Clemens (2-0) L: Chuck Porter (5-2) S: Bob Stanley (9) | Fifth | 16 out |
| Sunday, June 3 |
| » Lost to Red Sox (24-26), 6-3 | County Stadium (12-12) | 22-27 | Lost 3 |
| » W: Mark Clear (3-0) L: Pete Ladd (2-3) | Fifth | 16 out |
| Monday, June 4 |
| » Lost to Orioles (31-22), 6-2 | Memorial Stadium (0-1) | 22-28 | Lost 4 |
| » W: Mike Boddicker (7-4) L: Pete Ladd (2-4) | Fifth | 17 out |
| » Major-league debuts: Jack Lazorko (Brewers) |
| Tuesday, June 5 |
| » Defeated Orioles (31-23), 8-3 | Memorial Stadium (1-1) | 23-28 | |
| » W: Jaime Cocanower (5-5) L: Bill Swaggerty (1-1) | Fifth | 16 out |
| Wednesday, June 6 |
| » Lost to Orioles (32-23), 3-0 | Memorial Stadium (1-2) | 23-29 | |
| » W: Scott McGregor (7-4) L: Don Sutton (3-5) | Fifth | 16 out |
| Thursday, June 7 |
| » Defeated Red Sox (26-28), 6-3 | Fenway Park (1-0) | 24-29 | |
| » W: Bob McClure (1-1) L: Roger Clemens (2-1) S: Rollie Fingers (10) | Fifth | 16 out |
| Friday, June 8 |
| » Lost to Red Sox (27-28), 11-3 | Fenway Park (1-1) | 24-30 | |
| » W: Oil Can Boyd (1-3) L: Moose Haas (3-5) | Fifth | 17 out |
| Saturday, June 9 |
| » Lost to Red Sox (28-28), 15-6 | Fenway Park (1-2) | 24-31 | Lost 2 |
| » W: Bob Ojeda (6-5) L: Bob Gibson (0-1) S: Bob Stanley (11) | Fifth | 17 out |
| Sunday, June 10 |
| » Lost to Red Sox (29-28), 5-4 | Fenway Park (1-3) | 24-32 | Lost 3 |
| » W: Rich Gale (1-0) L: Rick Waits (0-2) | Sixth | 18½ out |
| Monday, June 11 |
| » Lost to Orioles (34-26), 3-1 | County Stadium (12-13) | 24-33 | Lost 4 |
| » W: Scott McGregor (8-4) L: Don Sutton (3-6) | Sixth | 19½ out |
| Tuesday, June 12 |
| » Lost to Orioles (35-26), 5-4 | County Stadium (12-14) | 24-34 | Lost 5 |
| » W: Tippy Martinez (3-4) L: Rollie Fingers (0-2) S: Sammy Stewart (1) | Sixth | 19½ out |
| Wednesday, June 13 |
| » Defeated Orioles (35-27), 6-1 | County Stadium (13-14) | 25-34 | |
| » W: Moose Haas (4-5) L: Mike Flanagan (5-5) | Sixth | 18½ out |
| Thursday, June 14 |
| » Defeated Orioles (35-28), 3-2 | County Stadium (14-14) | 26-34 | Won 2 |
| » W: Rick Waits (1-2) L: Storm Davis (6-3) S: Rollie Fingers (11) | Sixth | 18 out |
| Friday, June 15 |
| » Lost to Tigers (45-16), 3-2 | County Stadium (14-15) | 26-35 | |
| » W: Dan Petry (10-3) L: Jaime Cocanower (5-6) S: Willie Hernandez (11) | Sixth | 19 out |
| Saturday, June 16 |
| » Lost to Tigers (46-16), 6-0 | County Stadium (14-16) | 26-36 | Lost 2 |
| » W: Juan Berenguer (4-4) L: Don Sutton (3-7) | Sixth | 20 out |
| Sunday, June 17 |
| » Lost to Tigers (47-16), 7-4 | County Stadium (14-17) | 26-37 | Lost 3 |
| » W: Dave Rozema (3-0) L: Bob McClure (1-2) S: Aurelio Lopez (8) | Sixth | 21 out |
| Tuesday, June 19 |
| » Defeated Blue Jays (41-23), 6-5 | Exhibition Stadium (1-0) | 27-37 | |
| » W: Rollie Fingers (1-2) L: Jimmy Key (2-4) | Sixth | 20½ out |
| Wednesday, June 20 |
| » Defeated Blue Jays (41-24), 5-4 | Exhibition Stadium (2-0) | 28-37 | Won 2 |
| » W: Tom Tellmann (2-1) L: Doyle Alexander (5-3) | Sixth | 20½ out |
| Thursday, June 21 |
| » Defeated Tigers (49-18), 4-3 | Tiger Stadium (1-0) | 29-37 | Won 3 |
| » W: Don Sutton (4-7) L: Juan Berenguer (4-5) S: Rollie Fingers (12) | Sixth | 19½ out |
| Friday, June 22 |
| » Lost to Tigers (50-18), 7-3 | Tiger Stadium (1-1) | 29-38 | |
| » W: Dave Rozema (4-0) L: Bob McClure (1-3) S: Willie Hernandez (13) | Sixth | 20½ out |
| Saturday, June 23 |
| » Lost to Tigers (51-18), 5-1 | Tiger Stadium (1-2) | 29-39 | Lost 2 |
| » W: Milt Wilcox (8-5) L: Chuck Porter (5-3) | Sixth | 21½ out |
| Sunday, June 24 |
| » Lost to Tigers (52-18), 7-1 | Tiger Stadium (1-3) | 29-40 | Lost 3 |
| » W: Jack Morris (12-3) L: Moose Haas (4-6) S: Aurelio Lopez (9) | Sixth | 22½ out |
| Monday, June 25 |
| » Defeated Blue Jays (43-27), 2-1 | County Stadium (15-17) | 30-40 | |
| » W: Jaime Cocanower (6-6) L: Doyle Alexander (5-4) S: Rollie Fingers (13) | Sixth | 21 out |
| » Defeated Blue Jays (43-28), 9-4 | County Stadium (16-17) | 31-40 | Won 2 |
| » W: Bob McClure (2-3) L: Jim Acker (1-4) | Sixth | 21 out |
| Tuesday, June 26 |
| » Defeated Blue Jays (43-29), 6-3 | County Stadium (17-17) | 32-40 | Won 3 |
| » W: Don Sutton (5-7) L: Luis Leal (8-2) S: Rollie Fingers (14) | Sixth | 21 out |
| Wednesday, June 27 |
| » Defeated Blue Jays (43-30), 5-1 | County Stadium (18-17) | 33-40 | Won 4 |
| » W: Chuck Porter (6-3) L: Jim Clancy (6-8) S: Tom Tellmann (1) | Sixth | 20 out |
| Thursday, June 28 |
| » Lost to Angels (40-36), 7-3 | County Stadium (18-18) | 33-41 | |
| » W: Tommy John (4-6) L: Bob Gibson (0-2) S: Doug Corbett (4) | Sixth | 20½ out |
| Friday, June 29 |
| » Defeated Angels (40-37), 1-0 | County Stadium (19-18) | 34-41 | |
| » W: Moose Haas (5-6) L: Ron Romanick (8-8) S: Rollie Fingers (15) | Fifth | 20 out |
| Saturday, June 30 |
| » Lost to Angels (41-37), 2-0 | County Stadium (19-19) | 34-42 | |
| » W: Geoff Zahn (9-4) L: Jaime Cocanower (6-7) | Fifth | 21 out |
| Sunday, July 1 |
| » Lost to Angels (42-37), 7-6 | County Stadium (19-20) | 34-43 | Lost 2 |
| » W: Bruce Kison (2-1) L: Bob McClure (2-4) S: Luis Sanchez (9) | Fifth | 21 out |
| Monday, July 2 |
| » Defeated Mariners (38-43), 3-2 | County Stadium (20-20) | 35-43 | |
| » W: Don Sutton (6-7) L: Mike Moore (3-6) S: Rollie Fingers (16) | Fifth | 19½ out |
| » Defeated Mariners (38-44), 6-4 | County Stadium (21-20) | 36-43 | Won 2 |
| » W: Tom Tellmann (3-1) L: Salome Barojas (3-3) S: Rollie Fingers (17) | Fifth | 19½ out |
| Tuesday, July 3 |
| » Defeated Mariners (38-45), 11-6 | County Stadium (22-20) | 37-43 | Won 3 |
| » W: Pete Ladd (3-4) L: Matt Young (4-6) | Fifth | 18½ out |
| Wednesday, July 4 |
| » Defeated Mariners (38-46), 4-2 | County Stadium (23-20) | 38-43 | Won 4 |
| » W: Moose Haas (6-6) L: Ed Vande Berg (5-8) | Fifth | 17½ out |
| Thursday, July 5 |
| » Defeated Athletics (39-45), 7-5 | County Stadium (24-20) | 39-43 | Won 5 |
| » W: Jaime Cocanower (7-7) L: Bill Krueger (5-5) S: Rollie Fingers (18) | Fifth | 17½ out |
| Friday, July 6 |
| » Lost to Athletics (40-45), 7-6 | County Stadium (24-21) | 39-44 | |
| » W: Ray Burris (8-3) L: Pete Ladd (3-5) S: Bill Caudill (17) | Fifth | 18 out |
| » Lost to Athletics (41-45), 11-0 | County Stadium (24-22) | 39-45 | Lost 2 |
| » W: Curt Young (2-0) L: Mike Caldwell (4-6) | Fifth | 18 out |
| Saturday, July 7 |
| » Lost to Athletics (42-45), 8-2 | County Stadium (24-23) | 39-46 | Lost 3 |
| » W: Steve McCatty (6-6) L: Don Sutton (6-8) | Fifth | 19 out |
| Sunday, July 8 |
| » Lost to Athletics (43-45), 4-1 | County Stadium (24-24) | 39-47 | Lost 4 |
| » W: Lary Sorensen (3-9) L: Chuck Porter (6-4) S: Bill Caudill (18) | Fifth | 19 out |
| Thursday, July 12 |
| » Lost to Angels (45-42), 5-2 | Anaheim Stadium (1-2) | 39-48 | Lost 5 |
| » W: Mike Witt (9-7) L: Jaime Cocanower (7-8) | Fifth | 19 out |
| Friday, July 13 |
| » Defeated Angels (45-43), 5-4 | Anaheim Stadium (2-2) | 40-48 | |
| » W: Don Sutton (7-8) L: Geoff Zahn (9-6) S: Rollie Fingers (19) | Sixth | 19 out |
| Saturday, July 14 |
| » Lost to Angels (46-43), 2-1 | Anaheim Stadium (2-3) | 40-49 | |
| » W: Ron Romanick (9-9) L: Tom Tellmann (3-2) | Sixth | 20 out |
| Sunday, July 15 |
| » Lost to Angels (47-43), 7-6 | Anaheim Stadium (2-4) | 40-50 | Lost 2 |
| » W: Luis Sanchez (6-2) L: Bob McClure (2-5) | Sixth | 21 out |
| Monday, July 16 |
| » Lost to Mariners (43-50), 11-2 | Kingdome (0-4) | 40-51 | Lost 3 |
| » W: Salome Barojas (4-3) L: Tom Candiotti (0-1) | Sixth | 22 out |
| Tuesday, July 17 |
| » Lost to Mariners (44-50), 3-1 | Kingdome (0-5) | 40-52 | Lost 4 |
| » W: Mark Langston (8-7) L: Jaime Cocanower (7-9) S: Mike Stanton (7) | Sixth | 23 out |
| Wednesday, July 18 |
| » Defeated Mariners (44-51), 5-2 | Kingdome (1-5) | 41-52 | |
| » W: Don Sutton (8-8) L: Mike Moore (4-8) S: Rollie Fingers (20) | Sixth | 22 out |
| Thursday, July 19 |
| » Lost to Athletics (46-50), 4-1 | Oakland-Alameda County Stadium (0-3) | 41-53 | |
| » W: Steve McCatty (7-6) L: Moose Haas (6-7) | Sixth | 23 out |
| Friday, July 20 |
| » Defeated Athletics (46-51), 9-7 | Oakland-Alameda County Stadium (1-3) | 42-53 | |
| » W: Tom Tellmann (4-2) L: Bill Caudill (8-3) S: Rollie Fingers (21) | Sixth | 23 out |
| Saturday, July 21 |
| » Defeated Athletics (46-52), 7-4 | Oakland-Alameda County Stadium (2-3) | 43-53 | Won 2 |
| » W: Rick Waits (2-2) L: Chuck Rainey (5-8) S: Rollie Fingers (22) | Sixth | 23 out |
| Sunday, July 22 |
| » Lost to Athletics (47-52), 5-4 | Oakland-Alameda County Stadium (2-4) | 43-54 | |
| » W: Bill Krueger (7-6) L: Mike Caldwell (4-7) S: Bill Caudill (20) | Sixth | 24 out |
| Monday, July 23 |
| » Defeated Yankees (45-50), 6-4 | County Stadium (25-24) | 44-54 | |
| » W: Don Sutton (9-8) L: Ron Guidry (8-8) S: Rollie Fingers (23) | Sixth | 24 out |
| Tuesday, July 24 |
| » Defeated Yankees (45-51), 2-1 | County Stadium (26-24) | 45-54 | Won 2 |
| » W: Pete Ladd (4-5) L: Joe Cowley (1-1) | Sixth | 24 out |
| Wednesday, July 25 |
| » Lost to Yankees (46-51), 3-0 | County Stadium (26-25) | 45-55 | |
| » W: Dennis Rasmussen (4-3) L: Mike Caldwell (4-8) S: Dave Righetti (13) | Sixth | 24 out |
| Friday, July 27 |
| » Lost to Royals (48-52), 12-8 | County Stadium (26-26) | 45-56 | Lost 2 |
| » W: Larry Gura (11-7) L: Jaime Cocanower (7-10) S: Mark Huismann (1) | Sixth | 24 out |
| » Defeated Royals (48-53), 3-1 | County Stadium (27-26) | 46-56 | |
| » W: Tom Candiotti (1-1) L: Mike Jones (1-2) S: Rick Waits (2) | Sixth | 24 out |
| Saturday, July 28 |
| » Defeated Royals (48-54), 3-2 | County Stadium (28-26) | 47-56 | Won 2 |
| » W: Don Sutton (10-8) L: Bud Black (10-9) S: Tom Tellmann (2) | Sixth | 23 out |
| Sunday, July 29 |
| » Lost to Royals (49-54), 5-1 | County Stadium (28-27) | 47-57 | |
| » W: Mark Gubicza (8-8) L: Moose Haas (6-8) | Sixth | 24 out |
| Monday, July 30 |
| » Lost to Yankees (49-52), 4-3 | Yankee Stadium (2-2) | 47-58 | Lost 2 |
| » W: Dennis Rasmussen (5-3) L: Mike Caldwell (4-9) S: Dave Righetti (16) | Sixth | 24½ out |
| Tuesday, July 31 |
| » Lost to Yankees (50-52), 7-4 | Yankee Stadium (2-3) | 47-59 | Lost 3 |
| » W: Ray Fontenot (4-6) L: Andy Beene (0-1) S: Dave Righetti (17) | Sixth | 25 out |
| Wednesday, August 1 |
| » Lost to Yankees (51-52), 7-3 | Yankee Stadium (2-4) | 47-60 | Lost 4 |
| » W: Phil Niekro (13-5) L: Jaime Cocanower (7-11) | Sixth | 25 out |
| Thursday, August 2 |
| » Lost to Yankees (52-52), 6-4 | Yankee Stadium (2-5) | 47-61 | Lost 5 |
| » W: Jay Howell (5-4) L: Tom Tellmann (4-3) | Sixth | 26 out |
| Friday, August 3 |
| » Lost to White Sox (52-54), 5-1 | County Stadium (28-28) | 47-62 | Lost 6 |
| » W: Floyd Bannister (9-7) L: Don Sutton (10-9) | Sixth | 26 out |
| Saturday, August 4 |
| » Lost to White Sox (53-54), 7-3 | County Stadium (28-29) | 47-63 | Lost 7 |
| » W: Tom Seaver (11-6) L: Moose Haas (6-9) S: Jerry Don Gleaton (2) | Sixth | 26 out |
| Sunday, August 5 |
| » Lost to White Sox (54-54), 7-0 | County Stadium (28-30) | 47-64 | Lost 8 |
| » W: Richard Dotson (12-8) L: Mike Caldwell (4-10) | Sixth | 25½ out |
| Monday, August 6 |
| » Lost to White Sox (55-54), 5-3 | County Stadium (28-31) | 47-65 | Lost 9 |
| » W: Gene Nelson (2-4) L: Jaime Cocanower (7-12) S: Juan Agosto (4) | Sixth | 26 out |
| Tuesday, August 7 |
| » Lost to Royals (55-56), 8-5 | Royals Stadium (2-2) | 47-66 | Lost 10 |
| » W: Joe Beckwith (5-2) L: Pete Ladd (4-6) S: Dan Quisenberry (30) | Seventh | 26½ out |
| Wednesday, August 8 |
| » Defeated Royals (55-57), 3-2 | Royals Stadium (3-2) | 48-66 | |
| » W: Don Sutton (11-9) L: Bud Black (10-10) S: Rick Waits (3) | Sixth | 25½ out |
| Thursday, August 9 |
| » Lost to Royals (56-57), 5-4 | Royals Stadium (3-3) | 48-67 | |
| » W: Mark Huismann (2-3) L: Pete Ladd (4-7) | Seventh | 26 out |
| Friday, August 10 |
| » Defeated White Sox (57-57), 4-2 | Comiskey Park I (2-2) | 49-67 | |
| » W: Mike Caldwell (5-10) L: Richard Dotson (12-9) S: Tom Tellmann (3) | Fifth | 26 out |
| Saturday, August 11 |
| » Defeated White Sox (57-58), 10-5 | Comiskey Park I (3-2) | 50-67 | Won 2 |
| » W: Jaime Cocanower (8-12) L: Gene Nelson (2-5) | Fifth | 26 out |
| Sunday, August 12 |
| » Defeated White Sox (57-59), 8-1 | Comiskey Park I (4-2) | 51-67 | Won 3 |
| » W: Bob McClure (3-5) L: La Marr Hoyt (10-12) | Fourth | 26 out |
| Monday, August 13 |
| » Lost to Twins (61-55), 5-1 | Hubert H. Humphrey Metrodome (1-3) | 51-68 | |
| » W: John Butcher (10-7) L: Don Sutton (11-10) | Fifth | 26½ out |
| Tuesday, August 14 |
| » Lost to Twins (62-55), 3-2 | Hubert H. Humphrey Metrodome (1-4) | 51-69 | Lost 2 |
| » W: Ed Hodge (4-2) L: Moose Haas (6-10) S: Ron Davis (23) | Fifth | 26 out |
| Wednesday, August 15 |
| » Defeated Twins (62-56), 8-4 | Hubert H. Humphrey Metrodome (2-4) | 52-69 | |
| » W: Mike Caldwell (6-10) L: Ken Schrom (4-6) S: Tom Tellmann (4) | Fourth | 26 out |
| Friday, August 17 |
| » Lost to Indians (53-70), 5-3 | Cleveland Stadium (2-2) | 52-70 | |
| » W: Bert Blyleven (13-5) L: Jaime Cocanower (8-13) S: Ernie Camacho (16) | Sixth | 27½ out |
| Sunday, August 19 |
| » Lost to Indians (54-70), 8-6 | Cleveland Stadium (2-3) | 52-71 | Lost 2 |
| » W: Tom Waddell (4-4) L: Pete Ladd (4-8) | Seventh | 28½ out |
| » Lost to Indians (55-70), 2-1 | Cleveland Stadium (2-4) | 52-72 | Lost 3 |
| » W: Steve Comer (3-7) L: Rick Waits (2-3) | Seventh | 28½ out |
| Wednesday, August 22 |
| » Lost to Twins (66-58), 5-2 | County Stadium (28-32) | 52-73 | Lost 4 |
| » W: Mike Smithson (13-9) L: Mike Caldwell (6-11) | Seventh | 31 out |
| » Lost to Twins (67-58), 4-3 | County Stadium (28-33) | 52-74 | Lost 5 |
| » W: Rick Lysander (3-1) L: Ray Searage (0-1) S: Ron Davis (25) | Seventh | 31 out |
| Thursday, August 23 |
| » Defeated Twins (67-59), 5-2 | County Stadium (29-33) | 53-74 | |
| » W: Bob McClure (4-5) L: Frank Viola (14-11) | Seventh | 30½ out |
| Friday, August 24 |
| » Lost to Rangers (57-71), 10-3 | County Stadium (29-34) | 53-75 | |
| » W: Frank Tanana (14-11) L: Andy Beene (0-2) | Seventh | 30½ out |
| Saturday, August 25 |
| » Defeated Rangers (57-72), 7-6 | County Stadium (30-34) | 54-75 | |
| » W: Don Sutton (12-10) L: Charlie Hough (13-12) S: Jack Lazorko (1) | Seventh | 30½ out |
| Sunday, August 26 |
| » Defeated Rangers (57-73), 6-3 | County Stadium (31-34) | 55-75 | Won 2 |
| » W: Moose Haas (7-10) L: Mike Mason (8-11) S: Ray Searage (1) | Seventh | 30½ out |
| Monday, August 27 |
| » Lost to Indians (58-74), 7-1 | County Stadium (31-35) | 55-76 | |
| » W: Bert Blyleven (15-5) L: Mike Caldwell (6-12) | Seventh | 31 out |
| Tuesday, August 28 |
| » Lost to Indians (59-74), 8-5 | County Stadium (31-36) | 55-77 | Lost 2 |
| » W: Neal Heaton (9-13) L: Bob McClure (4-6) S: Ernie Camacho (18) | Seventh | 32 out |
| Wednesday, August 29 |
| » Lost to Indians (60-74), 5-2 | County Stadium (31-37) | 55-78 | Lost 3 |
| » W: Mike Jeffcoat (5-1) L: Jaime Cocanower (8-14) S: Ernie Camacho (19) | Sixth | 32 out |
| Thursday, August 30 |
| » Defeated Indians (60-75), 7-6 | County Stadium (32-37) | 56-78 | |
| » W: Tom Tellmann (5-3) L: Steve Farr (3-11) S: Pete Ladd (3) | Sixth | 31 out |
| Friday, August 31 |
| » Lost to Rangers (60-74), 7-6 | Arlington Stadium (1-3) | 56-79 | |
| » W: Joey McLaughlin (1-1) L: Pete Ladd (4-9) | Seventh | 31 out |
| Saturday, September 1 |
| » Lost to Rangers (61-74), 8-4 | Arlington Stadium (1-4) | 56-80 | Lost 2 |
| » W: Dave Stewart (5-12) L: Mike Caldwell (6-13) S: Dave Schmidt (12) | Seventh | 31 out |
| Monday, September 3 |
| » Lost to Red Sox (73-64), 8-5 | County Stadium (32-38) | 56-81 | Lost 3 |
| » W: Oil Can Boyd (10-9) L: Jaime Cocanower (8-15) S: Bob Stanley (19) | Seventh | 31½ out |
| Tuesday, September 4 |
| » Lost to Red Sox (74-64), 3-1 | County Stadium (32-39) | 56-82 | Lost 4 |
| » W: Al Nipper (8-5) L: Don Sutton (12-11) | Seventh | 31½ out |
| Wednesday, September 5 |
| » Defeated Red Sox (74-65), 7-5 | County Stadium (33-39) | 57-82 | |
| » W: Moose Haas (8-10) L: Mike Brown (1-7) S: Ray Searage (2) | Seventh | 31½ out |
| Friday, September 7 |
| » Defeated Orioles (75-64), 10-8 | Memorial Stadium (2-2) | 58-82 | Won 2 |
| » W: Tom Tellmann (6-3) L: Sammy Stewart (7-3) S: Ray Searage (3) | Sixth | 31½ out |
| Saturday, September 8 |
| » Lost to Orioles (76-64), 5-3 | Memorial Stadium (2-3) | 58-83 | |
| » W: Storm Davis (13-7) L: Jack Lazorko (0-1) S: Sammy Stewart (12) | Sixth | 32½ out |
| Sunday, September 9 |
| » Lost to Orioles (77-64), 4-0 | Memorial Stadium (2-4) | 58-84 | Lost 2 |
| » W: Mike Boddicker (18-9) L: Bob Gibson (0-3) | Seventh | 33½ out |
| Monday, September 10 |
| » Defeated Red Sox (75-68), 7-4 | Fenway Park (2-3) | 59-84 | |
| » W: Don Sutton (13-11) L: Mike Brown (1-8) S: Ray Searage (4) | Seventh | 32½ out |
| Tuesday, September 11 |
| » Defeated Red Sox (75-69), 14-6 | Fenway Park (3-3) | 60-84 | Won 2 |
| » W: Moose Haas (9-10) L: Oil Can Boyd (10-10) | Seventh | 32½ out |
| Wednesday, September 12 |
| » Lost to Red Sox (76-69), 5-4 | Fenway Park (3-4) | 60-85 | |
| » W: Bob Ojeda (11-11) L: Bob McClure (4-7) S: Bob Stanley (20) | Seventh | 32½ out |
| Friday, September 14 |
| » Defeated Orioles (79-66), 4-2 | County Stadium (34-39) | 61-85 | |
| » W: Tom Candiotti (2-1) L: Mike Boddicker (18-10) S: Ray Searage (5) | Seventh | 31½ out |
| Saturday, September 15 |
| » Defeated Orioles (79-67), 7-0 | County Stadium (35-39) | 62-85 | Won 2 |
| » W: Bob Gibson (1-3) L: Mike Flanagan (12-13) | Seventh | 31½ out |
| Sunday, September 16 |
| » Lost to Orioles (80-67), 11-8 | County Stadium (35-40) | 62-86 | |
| » W: Storm Davis (14-7) L: Don Sutton (13-12) | Seventh | 32½ out |
| Monday, September 17 |
| » Lost to Tigers (96-54), 7-3 | Tiger Stadium (1-4) | 62-87 | Lost 2 |
| » W: Roger Mason (1-1) L: Rick Waits (2-4) S: Aurelio Lopez (14) | Seventh | 33½ out |
| Tuesday, September 18 |
| » Lost to Tigers (97-54), 3-0 | Tiger Stadium (1-5) | 62-88 | Lost 3 |
| » W: Randy O'Neal (1-0) L: Bob McClure (4-8) S: Willie Hernandez (30) | Seventh | 34½ out |
| Wednesday, September 19 |
| » Lost to Tigers (98-54), 4-2 | Tiger Stadium (1-6) | 62-89 | Lost 4 |
| » W: Jack Morris (18-11) L: Tom Candiotti (2-2) S: Willie Hernandez (31) | Seventh | 35½ out |
| Thursday, September 20 |
| » Lost to Blue Jays (85-68), 6-4 | Exhibition Stadium (2-1) | 62-90 | Lost 5 |
| » W: Dave Stieb (15-7) L: Bob Gibson (1-4) S: Jimmy Key (10) | Seventh | 36 out |
| Friday, September 21 |
| » Defeated Blue Jays (85-69), 5-1 | Exhibition Stadium (3-1) | 63-90 | |
| » W: Don Sutton (14-12) L: Dennis Lamp (8-8) | Seventh | 35 out |
| Saturday, September 22 |
| » Lost to Blue Jays (86-69), 2-1 | Exhibition Stadium (3-2) | 63-91 | |
| » W: Doyle Alexander (16-5) L: Moose Haas (9-11) | Seventh | 36 out |
| Sunday, September 23 |
| » Defeated Blue Jays (86-70), 8-5 | Exhibition Stadium (4-2) | 64-91 | |
| » W: Jim Kern (1-1) L: Roy Lee Jackson (7-8) S: Ray Searage (6) | Seventh | 36 out |
| Monday, September 24< |