| Monday, April 2 |
| » Major-league debuts: Ross Jones (Mets) |
| Wednesday, April 4 |
| » Lost to Mariners (1-0), 3-2 | Kingdome (0-1) | 0-1 | |
| » W: Mike Stanton (1-0) L: Dennis Lamp (0-1) | Third | 1 out |
| Thursday, April 5 |
| » Defeated Mariners (1-1), 13-5 | Kingdome (1-1) | 1-1 | |
| » W: Luis Leal (1-0) L: Jim Beattie (0-1) | Third | 1 out |
| Friday, April 6 |
| » Defeated Angels (1-3), 11-5 | Anaheim Stadium (1-0) | 2-1 | Won 2 |
| » W: Jimmy Key (1-0) L: Steve Brown (0-1) | Second | 1 out |
| » Major-league debuts: Jimmy Key (Blue Jays) |
| Saturday, April 7 |
| » Defeated Angels (1-4), 3-1 | Anaheim Stadium (2-0) | 3-1 | Won 3 |
| » W: Dave Stieb (1-0) L: Ken Forsch (1-1) S: Dennis Lamp (1) | Third | 1 out |
| Sunday, April 8 |
| » Lost to Angels (2-4), 4-3 | Anaheim Stadium (2-1) | 3-2 | |
| » W: Luis Sanchez (1-1) L: Roy Lee Jackson (0-1) | Third | 2 out |
| Monday, April 9 |
| » Lost to Athletics (5-1), 4-3 | Oakland-Alameda County Stadium (0-1) | 3-3 | Lost 2 |
| » W: Bill Caudill (1-0) L: Dennis Lamp (0-2) | Third | 2½ out |
| Tuesday, April 10 |
| » Defeated Athletics (5-2), 3-0 | Oakland-Alameda County Stadium (1-1) | 4-3 | |
| » W: Luis Leal (2-0) L: Lary Sorensen (1-1) S: Roy Lee Jackson (1) | Third | 2½ out |
| Wednesday, April 11 |
| » Major-league debuts: Alvin Davis (Mariners) |
| Friday, April 13 |
| » Defeated Rangers (2-6), 3-2 | Arlington Stadium (1-0) | 5-3 | Won 2 |
| » W: Dennis Lamp (1-2) L: Dave Tobik (1-2) S: Jimmy Key (1) | Second | 3 out |
| Saturday, April 14 |
| » Lost to Rangers (3-6), 6-2 | Arlington Stadium (1-1) | 5-4 | |
| » W: Charlie Hough (1-1) L: Jim Clancy (0-1) | Third | 3½ out |
| Sunday, April 15 |
| » Defeated Rangers (3-7), 2-1 | Arlington Stadium (2-1) | 6-4 | |
| » W: Dennis Lamp (2-2) L: Dave Stewart (0-3) | Second | 3 out |
| Tuesday, April 17 |
| » Defeated Orioles (2-8), 3-2 | Exhibition Stadium (1-0) | 7-4 | Won 2 |
| » W: Jimmy Key (2-0) L: Tippy Martinez (0-1) S: Dennis Lamp (2) | Second | 2½ out |
| Wednesday, April 18 |
| » Defeated Orioles (2-9), 7-1 | Exhibition Stadium (2-0) | 8-4 | Won 3 |
| » W: Dave Stieb (2-0) L: Jim Palmer (0-2) | Second | 2½ out |
| Thursday, April 19 |
| » Defeated Orioles (2-10), 2-1 | Exhibition Stadium (3-0) | 9-4 | Won 4 |
| » W: Jim Clancy (1-1) L: Scott McGregor (1-3) | Second | 1½ out |
| Friday, April 20 |
| » Lost to Angels (8-8), 10-6 | Exhibition Stadium (3-1) | 9-5 | |
| » W: Luis Sanchez (2-1) L: Jim Acker (0-1) | Second | 2½ out |
| » Major-league debuts: Kelly Gruber (Blue Jays) |
| Saturday, April 21 |
| » Lost to Angels (9-8), 8-4 | Exhibition Stadium (3-2) | 9-6 | Lost 2 |
| » W: Ron Romanick (2-1) L: Jim Gott (0-1) | Second | 3½ out |
| Sunday, April 22 |
| » Lost to Angels (10-8), 9-6 | Exhibition Stadium (3-3) | 9-7 | Lost 3 |
| » W: Jim Slaton (1-0) L: Jimmy Key (2-1) S: Curt Kaufman (1) | Second | 4½ out |
| Monday, April 23 |
| » Defeated Mariners (9-7), 8-5 | Exhibition Stadium (4-3) | 10-7 | |
| » W: Dave Stieb (3-0) L: Mark Langston (1-1) S: Roy Lee Jackson (2) | Second | 4 out |
| Tuesday, April 24 |
| » Lost to Mariners (10-7), 4-2 | Exhibition Stadium (4-4) | 10-8 | |
| » W: Dave Beard (1-0) L: Jim Clancy (1-2) | Second | 5½ out |
| Wednesday, April 25 |
| » Defeated Athletics (10-9), 11-0 | Exhibition Stadium (5-4) | 11-8 | |
| » W: Luis Leal (3-0) L: Tim Conroy (0-2) | Second | 5½ out |
| Thursday, April 26 |
| » Lost to Athletics (11-9), 7-4 | Exhibition Stadium (5-5) | 11-9 | |
| » W: Mike Warren (3-2) L: Jim Gott (0-2) S: Tom Burgmeier (2) | Third | 6½ out |
| Friday, April 27 |
| » Defeated Royals (8-10), 1-0 | Royals Stadium (1-0) | 12-9 | |
| » W: Doyle Alexander (1-0) L: Mark Gubicza (0-2) S: Dennis Lamp (3) | Third | 5½ out |
| Saturday, April 28 |
| » Defeated Royals (8-11), 6-0 | Royals Stadium (2-0) | 13-9 | Won 2 |
| » W: Dave Stieb (4-0) L: Bret Saberhagen (1-1) | Second | 5½ out |
| Tuesday, May 1 |
| » Defeated Rangers (8-15), 10-4 | Exhibition Stadium (6-5) | 14-9 | Won 3 |
| » W: Luis Leal (4-0) L: Frank Tanana (2-3) S: Dennis Lamp (4) | Second | 6½ out |
| » Lost to Rangers (9-15), 4-1 | Exhibition Stadium (6-6) | 14-10 | |
| » W: Danny Darwin (3-0) L: Doyle Alexander (1-1) | Second | 6½ out |
| Wednesday, May 2 |
| » Defeated Rangers (9-16), 7-6 | Exhibition Stadium (7-6) | 15-10 | |
| » W: Jim Clancy (2-2) L: Charlie Hough (1-4) S: Dennis Lamp (5) | Second | 5½ out |
| Friday, May 4 |
| » Defeated Royals (9-13), 4-3 | Exhibition Stadium (8-6) | 16-10 | Won 2 |
| » W: Dave Stieb (5-0) L: Mark Huismann (0-2) | Second | 5 out |
| Saturday, May 5 |
| » Defeated Royals (9-14), 10-1 | Exhibition Stadium (9-6) | 17-10 | Won 3 |
| » W: Jim Gott (1-2) L: Danny Jackson (0-3) | Second | 5 out |
| Sunday, May 6 |
| » Defeated Royals (9-15), 2-1 | Exhibition Stadium (10-6) | 18-10 | Won 4 |
| » W: Roy Lee Jackson (1-1) L: Larry Gura (4-1) | Second | 5 out |
| Wednesday, May 9 |
| » Lost to Orioles (15-14), 7-4 | Memorial Stadium (0-1) | 18-11 | |
| » W: Scott McGregor (4-3) L: Jim Clancy (2-3) | Second | 7½ out |
| » Lost to Orioles (16-14), 7-3 | Memorial Stadium (0-2) | 18-12 | Lost 2 |
| » W: Tippy Martinez (1-3) L: Jimmy Key (2-2) | Second | 7½ out |
| Thursday, May 10 |
| » Defeated Orioles (16-15), 4-3 | Memorial Stadium (1-2) | 19-12 | |
| » W: Roy Lee Jackson (2-1) L: Dennis Martinez (1-1) | Second | 7 out |
| Saturday, May 12 |
| » Lost to Indians (12-16), 8-4 | Cleveland Stadium (0-1) | 19-13 | |
| » W: Bert Blyleven (4-2) L: Jim Acker (0-2) S: Ernie Camacho (4) | Second | 7½ out |
| Sunday, May 13 |
| » Tied Indians, 4-4 | Cleveland Stadium (0-1) | 19-13 | |
| » Starters: Jim Clancy vs Rick Sutcliffe | Second | 7½ out |
| Tuesday, May 15 |
| » Defeated Twins (19-18), 5-2 | Hubert H. Humphrey Metrodome (1-0) | 20-13 | |
| » W: Roy Lee Jackson (3-1) L: Ron Davis (2-3) | Second | 8 out |
| Wednesday, May 16 |
| » Defeated Twins (19-19), 8-7 | Hubert H. Humphrey Metrodome (2-0) | 21-13 | Won 2 |
| » W: Doyle Alexander (2-1) L: Pete Filson (3-1) S: Jim Acker (1) | Second | 8 out |
| Thursday, May 17 |
| » Defeated White Sox (18-19), 3-2 | Exhibition Stadium (11-6) | 22-13 | Won 3 |
| » W: Roy Lee Jackson (4-1) L: La Marr Hoyt (3-5) S: Dennis Lamp (6) | Second | 7½ out |
| Friday, May 18 |
| » Defeated White Sox (18-20), 4-3 | Exhibition Stadium (12-6) | 23-13 | Won 4 |
| » W: Jim Clancy (3-3) L: Britt Burns (2-2) S: Jimmy Key (2) | Second | 7½ out |
| Saturday, May 19 |
| » Defeated White Sox (18-21), 1-0 | Exhibition Stadium (13-6) | 24-13 | Won 5 |
| » W: Jim Gott (2-2) L: Tom Seaver (4-3) S: Dennis Lamp (7) | Second | 7½ out |
| Sunday, May 20 |
| » Lost to White Sox (19-21), 3-0 | Exhibition Stadium (13-7) | 24-14 | |
| » W: Richard Dotson (6-2) L: Dave Stieb (5-1) | Second | 8½ out |
| Monday, May 21 |
| » Defeated Twins (21-21), 3-2 | Exhibition Stadium (14-7) | 25-14 | |
| » W: Doyle Alexander (3-1) L: Ron Davis (2-4) | Second | 8 out |
| Tuesday, May 22 |
| » Defeated Twins (21-22), 3-2 | Exhibition Stadium (15-7) | 26-14 | Won 2 |
| » W: Roy Lee Jackson (5-1) L: Mike Smithson (6-4) | Second | 8 out |
| Wednesday, May 23 |
| » Defeated Twins (21-23), 4-1 | Exhibition Stadium (16-7) | 27-14 | Won 3 |
| » W: Jim Clancy (4-3) L: Frank Viola (4-5) S: Dennis Lamp (8) | Second | 8 out |
| Friday, May 25 |
| » Defeated Indians (16-23), 5-1 | Exhibition Stadium (17-7) | 28-14 | Won 4 |
| » W: Dave Stieb (6-1) L: Neal Heaton (2-4) | Second | 7½ out |
| Saturday, May 26 |
| » Defeated Indians (16-24), 2-1 | Exhibition Stadium (18-7) | 29-14 | Won 5 |
| » W: Doyle Alexander (4-1) L: Steve Farr (0-3) S: Jimmy Key (3) | Second | 6½ out |
| Sunday, May 27 |
| » Defeated Indians (16-25), 6-1 | Exhibition Stadium (19-7) | 30-14 | Won 6 |
| » W: Luis Leal (5-0) L: Rick Sutcliffe (3-4) | Second | 5 out |
| » Defeated Indians (16-26), 6-5 | Exhibition Stadium (20-7) | 31-14 | Won 7 |
| » W: Roy Lee Jackson (6-1) L: Ernie Camacho (1-4) | Second | 5 out |
| Tuesday, May 29 |
| » Lost to White Sox (22-25), 8-1 | Comiskey Park I (0-1) | 31-15 | |
| » W: La Marr Hoyt (4-5) L: Jim Clancy (4-4) | Second | 5½ out |
| Wednesday, May 30 |
| » Defeated White Sox (22-26), 2-1 | Comiskey Park I (1-1) | 32-15 | |
| » W: Dave Stieb (7-1) L: Britt Burns (2-4) S: Jimmy Key (4) | Second | 5½ out |
| Friday, June 1 |
| » Defeated Yankees (20-28), 10-2 | Exhibition Stadium (21-7) | 33-15 | Won 2 |
| » W: Doyle Alexander (5-1) L: Ray Fontenot (1-5) | Second | 5½ out |
| Saturday, June 2 |
| » Defeated Yankees (20-29), 9-8 | Exhibition Stadium (22-7) | 34-15 | Won 3 |
| » W: Dennis Lamp (3-2) L: Clay Christiansen (1-2) | Second | 4½ out |
| Sunday, June 3 |
| » Lost to Yankees (21-29), 15-2 | Exhibition Stadium (22-8) | 34-16 | |
| » W: Phil Niekro (8-3) L: Jim Clancy (4-5) | Second | 4½ out |
| Monday, June 4 |
| » Lost to Tigers (39-11), 6-3 | Tiger Stadium (0-1) | 34-17 | Lost 2 |
| » W: Aurelio Lopez (5-0) L: Jimmy Key (2-3) | Second | 5½ out |
| Tuesday, June 5 |
| » Defeated Tigers (39-12), 8-4 | Tiger Stadium (1-1) | 35-17 | |
| » W: Jim Acker (1-2) L: Glenn Abbott (2-2) | Second | 4½ out |
| Wednesday, June 6 |
| » Defeated Tigers (39-13), 6-3 | Tiger Stadium (2-1) | 36-17 | Won 2 |
| » W: Luis Leal (6-0) L: Dan Petry (8-3) | Second | 3½ out |
| Thursday, June 7 |
| » Lost to Tigers (40-13), 5-3 | Tiger Stadium (2-2) | 36-18 | |
| » W: Jack Morris (11-2) L: Jim Clancy (4-6) | Second | 4½ out |
| Friday, June 8 |
| » Lost to Yankees (23-31), 4-3 | Yankee Stadium (0-1) | 36-19 | Lost 2 |
| » W: Dave Righetti (2-0) L: Jim Acker (1-3) | Second | 5½ out |
| Saturday, June 9 |
| » Lost to Yankees (24-31), 2-1 | Yankee Stadium (0-2) | 36-20 | Lost 3 |
| » W: Ron Guidry (5-4) L: Dave Stieb (7-2) | Second | 5½ out |
| Sunday, June 10 |
| » Lost to Yankees (25-31), 5-3 | Yankee Stadium (0-3) | 36-21 | Lost 4 |
| » W: Clay Christiansen (2-2) L: Doyle Alexander (5-2) S: Dave Righetti (7) | Second | 7 out |
| Monday, June 11 |
| » Lost to Tigers (44-14), 5-4 | Exhibition Stadium (22-9) | 36-22 | Lost 5 |
| » W: Dave Rozema (2-0) L: Luis Leal (6-1) S: Willie Hernandez (10) | Second | 8 out |
| Tuesday, June 12 |
| » Defeated Tigers (44-15), 12-3 | Exhibition Stadium (23-9) | 37-22 | |
| » W: Jim Clancy (5-6) L: Jack Morris (11-3) | Second | 7 out |
| Wednesday, June 13 |
| » Defeated Tigers (44-16), 7-3 | Exhibition Stadium (24-9) | 38-22 | Won 2 |
| » W: Dave Stieb (8-2) L: Milt Wilcox (7-4) | Second | 6 out |
| Friday, June 15 |
| » Defeated Red Sox (31-31), 4-3 | Exhibition Stadium (25-9) | 39-22 | Won 3 |
| » W: Dennis Lamp (4-2) L: Mark Clear (5-1) | Second | 6 out |
| Saturday, June 16 |
| » Defeated Red Sox (31-32), 7-0 | Exhibition Stadium (26-9) | 40-22 | Won 4 |
| » W: Luis Leal (7-1) L: Bruce Hurst (8-5) | Second | 6 out |
| Sunday, June 17 |
| » Defeated Red Sox (31-33), 5-3 | Exhibition Stadium (27-9) | 41-22 | Won 5 |
| » W: Jim Clancy (6-6) L: Rich Gale (1-1) S: Roy Lee Jackson (3) | Second | 6 out |
| Tuesday, June 19 |
| » Lost to Brewers (27-37), 6-5 | Exhibition Stadium (27-10) | 41-23 | |
| » W: Rollie Fingers (1-2) L: Jimmy Key (2-4) | Second | 6½ out |
| Wednesday, June 20 |
| » Lost to Brewers (28-37), 5-4 | Exhibition Stadium (27-11) | 41-24 | Lost 2 |
| » W: Tom Tellmann (2-1) L: Doyle Alexander (5-3) | Second | 7½ out |
| Thursday, June 21 |
| » Defeated Red Sox (31-36), 5-2 | Fenway Park (1-0) | 42-24 | |
| » W: Luis Leal (8-1) L: Al Nipper (0-2) | Second | 6½ out |
| Friday, June 22 |
| » Lost to Red Sox (32-36), 8-1 | Fenway Park (1-1) | 42-25 | |
| » W: Roger Clemens (3-1) L: Jim Clancy (6-7) | Second | 7½ out |
| Saturday, June 23 |
| » Defeated Red Sox (32-37), 9-3 | Fenway Park (2-1) | 43-25 | |
| » W: Jim Gott (3-2) L: Rich Gale (1-2) | Second | 7½ out |
| Sunday, June 24 |
| » Lost to Red Sox (33-37), 5-3 | Fenway Park (2-2) | 43-26 | |
| » W: Bob Stanley (2-6) L: Dennis Lamp (4-3) | Second | 8½ out |
| Monday, June 25 |
| » Lost to Brewers (30-40), 2-1 | County Stadium (0-1) | 43-27 | Lost 2 |
| » W: Jaime Cocanower (6-6) L: Doyle Alexander (5-4) S: Rollie Fingers (13) | Second | 9 out |
| » Lost to Brewers (31-40), 9-4 | County Stadium (0-2) | 43-28 | Lost 3 |
| » W: Bob McClure (2-3) L: Jim Acker (1-4) | Second | 9 out |
| Tuesday, June 26 |
| » Lost to Brewers (32-40), 6-3 | County Stadium (0-3) | 43-29 | Lost 4 |
| » W: Don Sutton (5-7) L: Luis Leal (8-2) S: Rollie Fingers (14) | Second | 10 out |
| Wednesday, June 27 |
| » Lost to Brewers (33-40), 5-1 | County Stadium (0-4) | 43-30 | Lost 5 |
| » W: Chuck Porter (6-3) L: Jim Clancy (6-8) S: Tom Tellmann (1) | Second | 10 out |
| Thursday, June 28 |
| » Defeated Athletics (37-40), 9-6 | Exhibition Stadium (28-11) | 44-30 | |
| » W: Jim Gott (4-2) L: Keith Atherton (5-4) | Second | 9½ out |
| Friday, June 29 |
| » Lost to Athletics (38-40), 2-1 | Exhibition Stadium (28-12) | 44-31 | |
| » W: Ray Burris (7-3) L: Dave Stieb (8-3) S: Bill Caudill (16) | Second | 10 out |
| Saturday, June 30 |
| » Defeated Athletics (38-41), 6-1 | Exhibition Stadium (29-12) | 45-31 | |
| » W: Doyle Alexander (6-4) L: Bill Krueger (5-4) | Second | 10 out |
| » Major-league debuts: Mickey Tettleton (Athletics) |
| Sunday, July 1 |
| » Defeated Athletics (38-42), 7-6 | Exhibition Stadium (30-12) | 46-31 | Won 2 |
| » W: Jim Acker (2-4) L: Keith Atherton (5-5) S: Roy Lee Jackson (4) | Second | 9 out |
| Monday, July 2 |
| » Lost to Angels (43-37), 6-3 | Exhibition Stadium (30-13) | 46-32 | |
| » W: Mike Witt (8-7) L: Jim Clancy (6-9) S: Don Aase (1) | Second | 9 out |
| Tuesday, July 3 |
| » Defeated Angels (43-38), 4-0 | Exhibition Stadium (31-13) | 47-32 | |
| » W: Jim Gott (5-2) L: Tommy John (4-7) | Second | 8 out |
| Wednesday, July 4 |
| » Defeated Angels (43-39), 6-3 | Exhibition Stadium (32-13) | 48-32 | Won 2 |
| » W: Dave Stieb (9-3) L: Ron Romanick (8-9) | Second | 7 out |
| Thursday, July 5 |
| » Defeated Mariners (38-47), 10-8 | Exhibition Stadium (33-13) | 49-32 | Won 3 |
| » W: Doyle Alexander (7-4) L: Jim Beattie (8-8) S: Roy Lee Jackson (5) | Second | 7 out |
| Friday, July 6 |
| » Defeated Mariners (38-48), 9-2 | Exhibition Stadium (34-13) | 50-32 | Won 4 |
| » W: Luis Leal (9-2) L: Mark Langston (6-7) | Second | 6 out |
| Saturday, July 7 |
| » Lost to Mariners (39-48), 8-4 | Exhibition Stadium (34-14) | 50-33 | |
| » W: Mike Moore (4-6) L: Jim Clancy (6-10) S: Mike Stanton (5) | Second | 7 out |
| Sunday, July 8 |
| » Lost to Mariners (40-48), 7-1 | Exhibition Stadium (34-15) | 50-34 | Lost 2 |
| » W: Jim Beattie (9-8) L: Jim Gott (5-3) S: Ed Vande Berg (4) | Second | 7 out |
| Thursday, July 12 |
| » Lost to Athletics (44-45), 7-4 | Oakland-Alameda County Stadium (1-2) | 50-35 | Lost 3 |
| » W: Bill Krueger (6-5) L: Dennis Lamp (4-4) S: Bill Caudill (19) | Second | 7 out |
| Friday, July 13 |
| » Defeated Athletics (44-46), 6-3 | Oakland-Alameda County Stadium (2-2) | 51-35 | |
| » W: Luis Leal (10-2) L: Ray Burris (8-4) S: Roy Lee Jackson (6) | Second | 7 out |
| Saturday, July 14 |
| » Defeated Athletics (44-47), 2-1 | Oakland-Alameda County Stadium (3-2) | 52-35 | Won 2 |
| » W: Dave Stieb (10-3) L: Bill Caudill (8-2) | Second | 7 out |
| Sunday, July 15 |
| » Defeated Athletics (44-48), 6-3 | Oakland-Alameda County Stadium (4-2) | 53-35 | Won 3 |
| » W: Jim Clancy (7-10) L: Curt Young (2-1) S: Roy Lee Jackson (7) | Second | 7 out |
| Monday, July 16 |
| » Lost to Angels (48-43), 3-0 | Anaheim Stadium (2-2) | 53-36 | |
| » W: Jim Slaton (3-3) L: Jim Gott (5-4) | Second | 8 out |
| Tuesday, July 17 |
| » Lost to Angels (49-43), 5-3 | Anaheim Stadium (2-3) | 53-37 | Lost 2 |
| » W: Mike Witt (10-7) L: Jim Acker (2-5) S: Don Aase (2) | Second | 9 out |
| Wednesday, July 18 |
| » Defeated Angels (49-44), 8-2 | Anaheim Stadium (3-3) | 54-37 | |
| » W: Luis Leal (11-2) L: Geoff Zahn (9-7) | Second | 8 out |
| Thursday, July 19 |
| » Defeated Mariners (44-52), 8-1 | Kingdome (2-1) | 55-37 | Won 2 |
| » W: Dave Stieb (11-3) L: Ed Vande Berg (6-9) | Second | 8 out |
| Friday, July 20 |
| » Defeated Mariners (44-53), 12-7 | Kingdome (3-1) | 56-37 | Won 3 |
| » W: Jim Acker (3-5) L: Paul Mirabella (1-4) | Second | 8 out |
| Saturday, July 21 |
| » Lost to Mariners (45-53), 9-3 | Kingdome (3-2) | 56-38 | |
| » W: Salome Barojas (5-3) L: Dennis Lamp (4-5) | Second | 9 out |
| Sunday, July 22 |
| » Defeated Mariners (45-54), 5-3 | Kingdome (4-2) | 57-38 | |
| » W: Doyle Alexander (8-4) L: Mark Langston (8-8) S: Roy Lee Jackson (8) | Second | 9 out |
| Monday, July 23 |
| » Lost to Royals (44-52), 9-8 | Royals Stadium (2-1) | 57-39 | |
| » W: Joe Beckwith (3-2) L: Roy Lee Jackson (6-2) S: Dan Quisenberry (26) | Second | 10½ out |
| » Lost to Royals (45-52), 7-2 | Royals Stadium (2-2) | 57-40 | Lost 2 |
| » W: Frank Wills (1-1) L: Jim Gott (5-5) S: Bret Saberhagen (1) | Second | 10½ out |
| Tuesday, July 24 |
| » Lost to Royals (46-52), 5-4 | Royals Stadium (2-3) | 57-41 | Lost 3 |
| » W: Mark Gubicza (7-8) L: Dave Stieb (11-4) S: Dan Quisenberry (27) | Second | 11½ out |
| Wednesday, July 25 |
| » Lost to Royals (47-52), 5-4 | Royals Stadium (2-4) | 57-42 | Lost 4 |
| » W: Dan Quisenberry (4-2) L: Bryan Clark (0-1) | Second | 11½ out |
| Friday, July 27 |
| » Lost to Rangers (42-60), 4-2 | Exhibition Stadium (34-16) | 57-43 | Lost 5 |
| » W: Charlie Hough (11-8) L: Doyle Alexander (8-5) | Second | 12 out |
| Saturday, July 28 |
| » Lost to Rangers (43-60), 5-4 | Exhibition Stadium (34-17) | 57-44 | Lost 6 |
| » W: Mike Mason (7-9) L: Roy Lee Jackson (6-3) S: Dave Schmidt (6) | Second | 12 out |
| Sunday, July 29 |
| » Defeated Rangers (43-61), 6-2 | Exhibition Stadium (35-17) | 58-44 | |
| » W: Dave Stieb (12-4) L: Danny Darwin (6-6) | Second | 12 out |
| Monday, July 30 |
| » Lost to Royals (50-54), 7-4 | Exhibition Stadium (35-18) | 58-45 | |
| » W: Charlie Leibrandt (5-4) L: Jim Clancy (7-11) | Second | 12½ out |
| Tuesday, July 31 |
| » Defeated Royals (50-55), 6-5 | Exhibition Stadium (36-18) | 59-45 | |
| » W: Doyle Alexander (9-5) L: Frank Wills (1-2) S: Jim Gott (1) | Second | 12 out |
| Wednesday, August 1 |
| » Defeated Royals (50-56), 4-1 | Exhibition Stadium (37-18) | 60-45 | Won 2 |
| » W: Luis Leal (12-2) L: Larry Gura (11-8) S: Jim Gott (2) | Second | 11 out |
| Friday, August 3 |
| » Defeated Orioles (58-49), 5-2 | Memorial Stadium (2-2) | 61-45 | Won 3 |
| » W: Roy Lee Jackson (7-3) L: Scott McGregor (12-10) | Second | 10½ out |
| Saturday, August 4 |
| » Defeated Orioles (58-50), 6-2 | Memorial Stadium (3-2) | 62-45 | Won 4 |
| » W: Jim Clancy (8-11) L: Mike Flanagan (9-11) | Second | 9½ out |
| Sunday, August 5 |
| » Defeated Orioles (58-51), 4-3 | Memorial Stadium (4-2) | 63-45 | Won 5 |
| » W: Jimmy Key (3-4) L: Tippy Martinez (4-8) S: Dennis Lamp (9) | Second | 8 out |
| Monday, August 6 |
| » Lost to Rangers (47-64), 5-4 | Arlington Stadium (2-2) | 63-46 | |
| » W: Mike Mason (8-9) L: Roy Lee Jackson (7-4) | Second | 8½ out |
| Tuesday, August 7 |
| » Lost to Rangers (48-64), 7-6 | Arlington Stadium (2-3) | 63-47 | Lost 2 |
| » W: Dave Schmidt (5-4) L: Dennis Lamp (4-6) | Second | 9 out |
| Wednesday, August 8 |
| » Defeated Rangers (48-65), 7-2 | Arlington Stadium (3-3) | 64-47 | |
| » W: Jim Clancy (9-11) L: Danny Darwin (6-7) | Second | 8 out |
| Friday, August 10 |
| » Defeated Orioles (60-54), 2-0 | Exhibition Stadium (38-18) | 65-47 | Won 2 |
| » W: Doyle Alexander (10-5) L: Dennis Martinez (4-6) | Second | 8 out |
| Saturday, August 11 |
| » Defeated Orioles (60-55), 3-2 | Exhibition Stadium (39-18) | 66-47 | Won 3 |
| » W: Jim Gott (6-5) L: Storm Davis (12-5) | Second | 8 out |
| Sunday, August 12 |
| » Lost to Orioles (61-55), 5-4 | Exhibition Stadium (39-19) | 66-48 | |
| » W: Scott McGregor (13-11) L: Roy Lee Jackson (7-5) S: Tippy Martinez (16) | Second | 9 out |
| Monday, August 13 |
| » Lost to Orioles (62-55), 2-1 | Exhibition Stadium (39-20) | 66-49 | Lost 2 |
| » W: Mike Boddicker (14-8) L: Jim Clancy (9-12) | Second | 9½ out |
| Tuesday, August 14 |
| » Defeated Indians (49-69), 8-1 | Cleveland Stadium (1-1) | 67-49 | |
| » W: Doyle Alexander (11-5) L: Neal Heaton (8-13) | Second | 7½ out |
| » Defeated Indians (49-70), 9-5 | Cleveland Stadium (2-1) | 68-49 | Won 2 |
| » W: Dennis Lamp (5-6) L: Tom Waddell (2-4) | Second | 7½ out |
| Wednesday, August 15 |
| » Lost to Indians (50-70), 16-1 | Cleveland Stadium (2-2) | 68-50 | |
| » W: Don Schulze (2-4) L: Luis Leal (12-3) | Second | 9 out |
| » Lost to Indians (51-70), 4-3 | Cleveland Stadium (2-3) | 68-51 | Lost 2 |
| » W: Mike Jeffcoat (4-1) L: Jimmy Key (3-5) | Second | 9 out |
| Thursday, August 16 |
| » Lost to Indians (52-70), 6-5 | Cleveland Stadium (2-4) | 68-52 | Lost 3 |
| » W: Tom Waddell (3-4) L: Dennis Lamp (5-7) | Second | 10 out |
| Friday, August 17 |
| » Defeated White Sox (58-62), 4-3 | Comiskey Park I (2-1) | 69-52 | |
| » W: Jim Clancy (10-12) L: La Marr Hoyt (10-13) | Second | 10 out |
| Saturday, August 18 |
| » Lost to White Sox (59-62), 7-6 | Comiskey Park I (2-2) | 69-53 | |
| » W: Bert Roberge (3-0) L: Roy Lee Jackson (7-6) S: Juan Agosto (7) | Second | 11 out |
| Sunday, August 19 |
| » Defeated White Sox (59-63), 7-4 | Comiskey Park I (3-2) | 70-53 | |
| » W: Jimmy Key (4-5) L: Juan Agosto (2-1) | Second | 10 out |
| Tuesday, August 21 |
| » Lost to Indians (56-70), 3-1 | Exhibition Stadium (39-21) | 70-54 | |
| » W: Roy Smith (5-4) L: Dave Stieb (12-5) S: Ernie Camacho (17) | Second | 11½ out |
| Wednesday, August 22 |
| » Lost to Indians (57-70), 13-3 | Exhibition Stadium (39-22) | 70-55 | Lost 2 |
| » W: Bert Blyleven (14-5) L: Jim Clancy (10-13) | Second | 12½ out |
| » Major-league debuts: Junior Noboa (Indians) |
| Thursday, August 23 |
| » Defeated Indians (57-71), 6-1 | Exhibition Stadium (40-22) | 71-55 | |
| » W: Doyle Alexander (12-5) L: Don Schulze (2-5) | Second | 12 out |
| Friday, August 24 |
| » Defeated Twins (67-60), 6-2 | Hubert H. Humphrey Metrodome (3-0) | 72-55 | Won 2 |
| » W: Luis Leal (13-3) L: Rick Lysander (3-2) S: Jimmy Key (5) | Second | 11 out |
| Saturday, August 25 |
| » Lost to Twins (68-60), 5-4 | Hubert H. Humphrey Metrodome (3-1) | 72-56 | |
| » W: Bobby Castillo (2-0) L: Jim Gott (6-6) | Second | 12 out |
| Sunday, August 26 |
| » Defeated Twins (68-61), 2-1 | Hubert H. Humphrey Metrodome (4-1) | 73-56 | |
| » W: Dave Stieb (13-5) L: Ken Schrom (4-7) | Second | 12 out |
| Monday, August 27 |
| » Defeated Twins (68-62), 5-2 | Hubert H. Humphrey Metrodome (5-1) | 74-56 | Won 2 |
| » W: Dennis Lamp (6-7) L: Mike Smithson (13-10) S: Jimmy Key (6) | Second | 11½ out |
| Tuesday, August 28 |
| » Defeated White Sox (61-69), 7-6 | Exhibition Stadium (41-22) | 75-56 | Won 3 |
| » W: Bryan Clark (1-1) L: Ron Reed (0-5) | Second | 11½ out |
| Wednesday, August 29 |
| » Lost to White Sox (62-69), 8-5 | Exhibition Stadium (41-23) | 75-57 | |
| » W: Floyd Bannister (12-8) L: Luis Leal (13-4) S: Dan Spillner (2) | Second | 11½ out |
| Thursday, August 30 |
| » Defeated White Sox (62-70), 4-3 | Comiskey Park I (4-2) | 76-57 | |
| » W: Jim Gott (7-6) L: Tom Seaver (12-9) S: Jimmy Key (7) | Second | 10½ out |
| Friday, August 31 |
| » Defeated Twins (69-65), 7-0 | Exhibition Stadium (42-23) | 77-57 | Won 2 |
| » W: Dave Stieb (14-5) L: Bobby Castillo (2-1) | Second | 9½ out |
| Saturday, September 1 |
| » Defeated Twins (69-66), 12-4 | Exhibition Stadium (43-23) | 78-57 | Won 3 |
| » W: Dennis Lamp (7-7) L: Mike Smithson (13-11) S: Roy Lee Jackson (9) | Second | 8½ out |
| Sunday, September 2 |
| » Defeated Twins (69-67), 6-0 | Exhibition Stadium (44-23) | 79-57 | Won 4 |
| » W: Doyle Alexander (13-5) L: Frank Viola (14-12) | Second | 8½ out |
| Monday, September 3 |
| » Lost to Yankees (73-63), 2-0 | Yankee Stadium (0-4) | 79-58 | |
| » W: Joe Cowley (6-1) L: Luis Leal (13-5) S: Dave Righetti (24) | Second | 8½ out |
| Tuesday, September 4 |
| » Defeated Yankees (73-64), 6-4 | Yankee Stadium (1-4) | 80-58 | |
| » W: Jim Clancy (11-13) L: Mike Armstrong (3-2) S: Jimmy Key (8) | Second | 7½ out |
| Wednesday, September 5 |
| » Lost to Yankees (74-64), 4-3 | Yankee Stadium (1-5) | 80-59 | |
| » W: Dave Righetti (5-5) L: Roy Lee Jackson (7-7) | Second | 8½ out |
| Friday, September 7 |
| » Lost to Tigers (90-51), 7-4 | Exhibition Stadium (44-24) | 80-60 | Lost 2 |
| » W: Willie Hernandez (9-2) L: Ron Musselman (0-1) | Second | 9½ out |
| Saturday, September 8 |
| » Lost to Tigers (91-51), 10-4 | Exhibition Stadium (44-25) | 80-61 | Lost 3 |
| » W: Bill Scherrer (2-1) L: Luis Leal (13-6) S: Aurelio Lopez (13) | Second | 10½ out |
| Sunday, September 9 |
| » Lost to Tigers (92-51), 7-2 | Exhibition Stadium (44-26) | 80-62 | Lost 4 |
| » W: Milt Wilcox (16-7) L: Jim Clancy (11-14) | Second | 11½ out |
| Monday, September 10 |
| » Lost to Yankees (77-65), 6-2 | Exhibition Stadium (44-27) | 80-63 | Lost 5 |
| » W: John Montefusco (3-2) L: Dave Stieb (14-6) S: Jay Howell (7) | Second | 11½ out |
| Tuesday, September 11 |
| » Defeated Yankees (77-66), 10-3 | Exhibition Stadium (45-27) | 81-63 | |
| » W: Dennis Lamp (8-7) L: Dennis Rasmussen (8-5) S: Roy Lee Jackson (10) | Second | 11½ out |
| Wednesday, September 12 |
| » Defeated Yankees (77-67), 2-1 | Exhibition Stadium (46-27) | 82-63 | Won 2 |
| » W: Doyle Alexander (14-5) L: Phil Niekro (16-8) | Second | 10½ out |
| Thursday, September 13 |
| » Lost to Yankees (78-67), 6-1 | Exhibition Stadium (46-28) | 82-64 | |
| » W: Ray Fontenot (7-8) L: Luis Leal (13-7) | Second | 11 out |
| Friday, September 14 |
| » Defeated Tigers (93-54), 7-2 | Tiger Stadium (3-2) | 83-64 | |
| » W: Jim Clancy (12-14) L: Jack Morris (17-11) S: Jimmy Key (9) | Second | 10 out |
| Saturday, September 15 |
| » Lost to Tigers (94-54), 2-1 | Tiger Stadium (3-3) | 83-65 | |
| » W: Milt Wilcox (17-7) L: Dave Stieb (14-7) S: Willie Hernandez (29) | Second | 11 out |
| Sunday, September 16 |
| » Lost to Tigers (95-54), 8-3 | Tiger Stadium (3-4) | 83-66 | Lost 2 |
| » W: Juan Berenguer (9-10) L: Bryan Clark (1-2) | Second | 12 out |
| Monday, September 17 |
| » Defeated Red Sox (78-71), 5-4 | Exhibition Stadium (47-28) | 84-66 | |
| » W: Doyle Alexander (15-5) L: Bob Ojeda (11-12) | Second | 12 out |
| Tuesday, September 18 |
| » Lost to Red Sox (79-71), 10-3 | Exhibition Stadium (47-29) | 84-67 | |
| » W: Rich Gale (2-3) L: Luis Leal (13-8) | Second | 13 out |
| Wednesday, September 19 |
| » Lost to Red Sox (80-71), 10-4 | Exhibition Stadium (47-30) | 84-68 | Lost 2 |
| » W: Bruce Hurst (12-10) L: Jim Clancy (12-15) S: Mark Clear (8) | Second | 14 out |
| Thursday, September 20 |
| » Defeated Brewers (62-90), 6-4 | Exhibition Stadium (48-30) | 85-68 | |
| » W: Dave Stieb (15-7) L: Bob Gibson (1-4) S: Jimmy Key (10) | Second | 13½ out |
| Friday, September 21 |
| » Lost to Brewers (63-90), 5-1 | Exhibition Stadium (48-31) | 85-69 | |
| » W: Don Sutton (14-12) L: Dennis Lamp (8-8) | Second | 13½ out |
| Saturday, September 22 |
| » Defeated Brewers (63-91), 2-1 | Exhibition Stadium (49-31) | 86-69 | |
| » W: Doyle Alexander (16-5) L: Moose Haas (9-11) | Second | 13½ out |
| Sunday, September 23 |
| » Lost to Brewers (64-91), 8-5 | Exhibition Stadium (49-32) | 86-70 | |
| » W: Jim Kern (1-1) L: Roy Lee Jackson (7-8) S |