| Tuesday, April 3 |
| » Lost to Expos (1-0), 4-2 | Astrodome (0-1) | 0-1 | |
| » W: Charlie Lea (1-0) L: Joe Niekro (0-1) S: Jeff Reardon (1) | Second | 1 out |
| Wednesday, April 4 |
| » Defeated Expos (1-1), 8-2 | Astrodome (1-1) | 1-1 | |
| » W: Nolan Ryan (1-0) L: Bill Gullickson (0-1) S: Vern Ruhle (1) | Second | ½ out |
| Thursday, April 5 |
| » Major-league debuts: Ron Romanick (Angels) |
| Friday, April 6 |
| » Lost to Mets (2-1), 8-1 | Astrodome (1-2) | 1-2 | |
| » W: Walt Terrell (1-0) L: Mike Scott (0-1) | Second | 2 out |
| Saturday, April 7 |
| » Lost to Mets (3-1), 3-2 | Astrodome (1-3) | 1-3 | Lost 2 |
| » W: Dwight Gooden (1-0) L: Bob Knepper (0-1) S: Jesse Orosco (1) | Second | 3 out |
| Sunday, April 8 |
| » Lost to Mets (4-1), 3-1 | Astrodome (1-4) | 1-4 | Lost 3 |
| » W: Tim Leary (1-0) L: Joe Niekro (0-2) S: Doug Sisk (2) | Third | 3 out |
| Tuesday, April 10 |
| » Lost to Phillies (4-2), 3-1 | Veteran's Stadium (0-1) | 1-5 | Lost 4 |
| » W: John Denny (1-1) L: Nolan Ryan (1-1) S: Al Holland (1) | Fourth | 4 out |
| Wednesday, April 11 |
| » Lost to Phillies (5-2), 7-6 | Veteran's Stadium (0-2) | 1-6 | Lost 5 |
| » W: Bill Campbell (1-0) L: Bill Dawley (0-1) | Fifth | 5 out |
| Friday, April 13 |
| » Defeated Reds (4-5), 1-0 | Astrodome (2-4) | 2-6 | |
| » W: Joe Niekro (1-2) L: Mario Soto (1-1) S: Frank DiPino (1) | Fifth | 5½ out |
| Saturday, April 14 |
| » Defeated Reds (4-6), 9-1 | Astrodome (3-4) | 3-6 | Won 2 |
| » W: Bob Knepper (1-1) L: Jeff Russell (1-1) | Fourth | 4½ out |
| Sunday, April 15 |
| » Defeated Reds (4-7), 6-5 | Astrodome (4-4) | 4-6 | Won 3 |
| » W: Frank DiPino (1-0) L: Tom Hume (0-1) | Third | 4½ out |
| Monday, April 16 |
| » Lost to Dodgers (6-5), 5-4 | Astrodome (4-5) | 4-7 | |
| » W: Pat Zachry (1-0) L: Frank DiPino (1-1) S: Burt Hooton (1) | Fourth | 5 out |
| Tuesday, April 17 |
| » Lost to Dodgers (7-5), 1-0 | Astrodome (4-6) | 4-8 | Lost 2 |
| » W: Rick Honeycutt (2-0) L: Joe Niekro (1-3) | Fourth | 6 out |
| Wednesday, April 18 |
| » Defeated Dodgers (7-6), 3-0 | Astrodome (5-6) | 5-8 | |
| » W: Bob Knepper (2-1) L: Bob Welch (1-2) | Third | 5½ out |
| Friday, April 20 |
| » Lost to Braves (5-8), 8-7 | Atlanta-Fulton County Stadium (0-1) | 5-9 | |
| » W: Gene Garber (1-0) L: Vern Ruhle (0-1) | Fifth | 5 out |
| Saturday, April 21 |
| » Defeated Braves (5-9), 4-3 | Atlanta-Fulton County Stadium (1-1) | 6-9 | |
| » W: Bill Dawley (1-1) L: Steve Bedrosian (1-1) S: Frank DiPino (2) | Fourth | 5 out |
| Sunday, April 22 |
| » Defeated Braves (5-10), 3-1 | Atlanta-Fulton County Stadium (2-1) | 7-9 | Won 2 |
| » W: Joe Niekro (2-3) L: Pete Falcone (0-3) S: Frank DiPino (3) | Fourth | 4 out |
| Monday, April 23 |
| » Lost to Dodgers (11-7), 2-1 | Dodger Stadium (0-1) | 7-10 | |
| » W: Bob Welch (2-2) L: Bob Knepper (2-2) | Fourth | 5 out |
| Tuesday, April 24 |
| » Lost to Dodgers (12-7), 5-3 | Dodger Stadium (0-2) | 7-11 | Lost 2 |
| » W: Alejandro Pena (3-1) L: Mike Madden (0-1) S: Tom Niedenfuer (3) | Fourth | 6 out |
| Wednesday, April 25 |
| » Lost to Dodgers (13-7), 4-2 | Dodger Stadium (0-3) | 7-12 | Lost 3 |
| » W: Fernando Valenzuela (2-2) L: Nolan Ryan (1-2) | Fourth | 7 out |
| Friday, April 27 |
| » Lost to Braves (8-11), 6-0 | Astrodome (5-7) | 7-13 | Lost 4 |
| » W: Pete Falcone (1-3) L: Joe Niekro (2-4) | Fifth | 7 out |
| » Major-league debuts: Mark Bailey (Astros) |
| Saturday, April 28 |
| » Lost to Braves (9-11), 5-3 | Astrodome (5-8) | 7-14 | Lost 5 |
| » W: Rick Camp (2-0) L: Bob Knepper (2-3) S: Gene Garber (1) | Sixth | 7½ out |
| Sunday, April 29 |
| » Defeated Braves (9-12), 8-5 | Astrodome (6-8) | 8-14 | |
| » W: Mike Scott (1-1) L: Len Barker (2-3) | Fifth | 7 out |
| Tuesday, May 1 |
| » Lost to Reds (11-13), 2-1 | Riverfront Stadium (0-1) | 8-15 | |
| » W: John Franco (1-0) L: Bill Dawley (1-2) | Fifth | 8½ out |
| Wednesday, May 2 |
| » Lost to Reds (12-13), 3-2 | Riverfront Stadium (0-2) | 8-16 | Lost 2 |
| » W: Mario Soto (3-1) L: Joe Niekro (2-5) | Fifth | 8½ out |
| Friday, May 4 |
| » Lost to Mets (15-8), 2-0 | Shea Stadium (0-1) | 8-17 | Lost 3 |
| » W: Ron Darling (2-2) L: Bob Knepper (2-4) S: Jesse Orosco (5) | Sixth | 9 out |
| Saturday, May 5 |
| » Defeated Mets (15-9), 10-6 | Shea Stadium (1-1) | 9-17 | |
| » W: Bill Dawley (2-2) L: Jesse Orosco (2-1) | Sixth | 8 out |
| Sunday, May 6 |
| » Defeated Mets (15-10), 10-1 | Shea Stadium (2-1) | 10-17 | Won 2 |
| » W: Nolan Ryan (2-2) L: Dwight Gooden (2-2) | Sixth | 7½ out |
| Monday, May 7 |
| » Lost to Expos (15-13), 4-1 | Stade Olympique (0-1) | 10-18 | |
| » W: Steve Rogers (2-1) L: Joe Niekro (2-6) S: Andy McGaffigan (1) | Sixth | 7½ out |
| Wednesday, May 9 |
| » Defeated Phillies (13-15), 7-1 | Astrodome (7-8) | 11-18 | |
| » W: Bob Knepper (3-4) L: Charles Hudson (3-2) | Fifth | 7 out |
| Thursday, May 10 |
| » Defeated Phillies (13-16), 4-2 | Astrodome (8-8) | 12-18 | Won 2 |
| » W: Mike Scott (2-1) L: Jerry Koosman (2-5) S: Frank DiPino (4) | Fifth | 7 out |
| Friday, May 11 |
| » Defeated Cubs (17-13), 3-1 | Astrodome (9-8) | 13-18 | Won 3 |
| » W: Nolan Ryan (3-2) L: Dick Ruthven (2-4) S: Frank DiPino (5) | Fifth | 6 out |
| Saturday, May 12 |
| » Lost to Cubs (18-13), 5-4 | Astrodome (9-9) | 13-19 | |
| » W: Dickie Noles (1-1) L: Frank DiPino (1-2) S: Lee Smith (6) | Fifth | 6 out |
| Sunday, May 13 |
| » Defeated Cubs (18-14), 1-0 | Astrodome (10-9) | 14-19 | |
| » W: Mike Madden (1-1) L: Rick Reuschel (0-1) S: Vern Ruhle (2) | Fourth | 6 out |
| Monday, May 14 |
| » Lost to Pirates (11-19), 3-2 | Three Rivers Stadium (0-1) | 14-20 | |
| » W: Jose DeLeon (2-1) L: Bob Knepper (3-5) S: Kent Tekulve (4) | Fifth | 6 out |
| Tuesday, May 15 |
| » Lost to Pirates (12-19), 3-2 | Three Rivers Stadium (0-2) | 14-21 | Lost 2 |
| » W: Cecilio Guante (1-2) L: Frank DiPino (1-3) | Fifth | 6 out |
| Wednesday, May 16 |
| » Defeated Pirates (12-20), 1-0 | Three Rivers Stadium (1-2) | 15-21 | |
| » W: Nolan Ryan (4-2) L: John Candelaria (3-4) | Fifth | 5 out |
| Friday, May 18 |
| » Lost to Cubs (21-15), 7-6 | Wrigley Field (0-1) | 15-22 | |
| » W: Tim Stoddard (3-0) L: Dave Smith (0-1) | Fourth | 5 out |
| Saturday, May 19 |
| » Lost to Cubs (22-15), 5-4 | Wrigley Field (0-2) | 15-23 | Lost 2 |
| » W: Rick Reuschel (1-1) L: Bill Dawley (2-3) S: Lee Smith (7) | Fifth | 6 out |
| Sunday, May 20 |
| » Lost to Cubs (23-15), 10-3 | Wrigley Field (0-3) | 15-24 | Lost 3 |
| » W: Rich Bordi (1-0) L: Mike Scott (2-2) | Fifth | 7 out |
| Monday, May 21 |
| » Defeated Cardinals (21-21), 3-2 | Busch Stadium II (1-0) | 16-24 | |
| » W: Nolan Ryan (5-2) L: Bob Forsch (0-4) S: Frank DiPino (6) | Fifth | 6½ out |
| Tuesday, May 22 |
| » Defeated Cardinals (21-22), 4-3 | Busch Stadium II (2-0) | 17-24 | Won 2 |
| » W: Bill Dawley (3-3) L: Bruce Sutter (1-3) S: Mike LaCoss (1) | Fourth | 5½ out |
| Wednesday, May 23 |
| » Defeated Cardinals (21-23), 4-0 | Busch Stadium II (3-0) | 18-24 | Won 3 |
| » W: Bob Knepper (4-5) L: Joaquin Andujar (7-4) | Fifth | 5½ out |
| Friday, May 25 |
| » Lost to Pirates (16-23), 6-2 | Astrodome (10-10) | 18-25 | |
| » W: John Tudor (3-2) L: Mike Scott (2-3) | Fifth | 5 out |
| Saturday, May 26 |
| » Defeated Pirates (16-24), 2-0 | Astrodome (11-10) | 19-25 | |
| » W: Nolan Ryan (6-2) L: Jose DeLeon (2-2) | Fourth | 4 out |
| Sunday, May 27 |
| » Lost to Pirates (17-24), 2-1 | Astrodome (11-11) | 19-26 | |
| » W: Rick Rhoden (4-3) L: Joe Niekro (2-7) S: Rod Scurry (1) | Fifth | 5 out |
| » Major-league debuts: Jim Pankovits (Astros) |
| Monday, May 28 |
| » Lost to Pirates (18-24), 7-0 | Astrodome (11-12) | 19-27 | Lost 2 |
| » W: John Candelaria (5-4) L: Vern Ruhle (0-2) S: Don Robinson (4) | Fourth | 6 out |
| Tuesday, May 29 |
| » Defeated Cardinals (22-27), 1-0 | Astrodome (12-12) | 20-27 | |
| » W: Bob Knepper (5-5) L: Dave LaPoint (5-6) S: Frank DiPino (7) | Fourth | 5½ out |
| Wednesday, May 30 |
| » Lost to Cardinals (23-27), 6-4 | Astrodome (12-13) | 20-28 | |
| » W: Ricky Horton (1-0) L: Frank DiPino (1-4) S: Bruce Sutter (11) | Fifth | 6½ out |
| Friday, June 1 |
| » Lost to Dodgers (29-23), 6-2 | Dodger Stadium (0-4) | 20-29 | Lost 2 |
| » W: Rick Honeycutt (7-2) L: Vern Ruhle (0-3) | Fifth | 7½ out |
| Saturday, June 2 |
| » Defeated Dodgers (29-24), 9-3 | Dodger Stadium (1-4) | 21-29 | |
| » W: Joe Niekro (3-7) L: Jerry Reuss (2-3) | Fifth | 7 out |
| Sunday, June 3 |
| » Defeated Dodgers (29-25), 5-3 | Dodger Stadium (2-4) | 22-29 | Won 2 |
| » W: Bob Knepper (6-5) L: Bob Welch (4-6) | Fifth | 7 out |
| Monday, June 4 |
| » Lost to Padres (29-22), 3-0 | San Diego/Jack Murphy Stadium (0-1) | 22-30 | |
| » W: Ed Whitson (5-3) L: Mike Scott (2-4) S: Dave Dravecky (5) | Fifth | 8 out |
| Tuesday, June 5 |
| » Lost to Padres (30-22), 3-0 | San Diego/Jack Murphy Stadium (0-2) | 22-31 | Lost 2 |
| » W: Andy Hawkins (4-2) L: Vern Ruhle (0-4) | Fifth | 9 out |
| Wednesday, June 6 |
| » Lost to Padres (31-22), 4-3 | San Diego/Jack Murphy Stadium (0-3) | 22-32 | Lost 3 |
| » W: Rich Gossage (3-1) L: Dave Smith (0-2) | Fifth | 10 out |
| Thursday, June 7 |
| » Defeated Giants (17-36), 14-5 | Candlestick Park (1-0) | 23-32 | |
| » W: Joe Niekro (4-7) L: Bill Laskey (1-6) | Fifth | 10 out |
| Friday, June 8 |
| » Lost to Giants (18-36), 5-4 | Candlestick Park (1-1) | 23-33 | |
| » W: Randy Lerch (2-1) L: Bob Knepper (6-6) S: Greg Minton (3) | Fifth | 10 out |
| Saturday, June 9 |
| » Lost to Giants (19-36), 6-5 | Candlestick Park (1-2) | 23-34 | Lost 2 |
| » W: Frank Williams (3-0) L: Bill Dawley (3-4) | Fifth | 10½ out |
| Sunday, June 10 |
| » Defeated Giants (19-37), 7-4 | Candlestick Park (2-2) | 24-34 | |
| » W: Vern Ruhle (1-4) L: Jeff Robinson (3-6) | Fifth | 10½ out |
| Monday, June 11 |
| » Defeated Reds (28-33), 3-2 | Astrodome (13-13) | 25-34 | Won 2 |
| » W: Mike LaCoss (1-0) L: Ted Power (2-3) | Fifth | 10½ out |
| Tuesday, June 12 |
| » Defeated Reds (28-34), 7-0 | Astrodome (14-13) | 26-34 | Won 3 |
| » W: Joe Niekro (5-7) L: Bruce Berenyi (3-7) | Fifth | 10½ out |
| Wednesday, June 13 |
| » Lost to Reds (29-34), 5-4 | Astrodome (14-14) | 26-35 | |
| » W: Bob Owchinko (3-2) L: Frank DiPino (1-5) | Fifth | 11 out |
| Thursday, June 14 |
| » Defeated Dodgers (35-30), 3-1 | Astrodome (15-14) | 27-35 | |
| » W: Mike Scott (3-4) L: Fernando Valenzuela (6-7) S: Dave Smith (1) | Fifth | 10 out |
| Friday, June 15 |
| » Defeated Dodgers (35-31), 3-2 | Astrodome (16-14) | 28-35 | Won 2 |
| » W: Bill Dawley (4-4) L: Orel Hershiser (2-3) | Fifth | 10 out |
| Saturday, June 16 |
| » Defeated Dodgers (35-32), 7-5 | Astrodome (17-14) | 29-35 | Won 3 |
| » W: Mike Madden (2-1) L: Burt Hooton (0-3) S: Mike LaCoss (2) | Fifth | 9 out |
| Sunday, June 17 |
| » Defeated Dodgers (35-33), 1-0 | Astrodome (18-14) | 30-35 | Won 4 |
| » W: Nolan Ryan (7-2) L: Bob Welch (5-7) S: Dave Smith (2) | Fourth | 8 out |
| Tuesday, June 19 |
| » Lost to Padres (38-26), 2-0 | Astrodome (18-15) | 30-36 | |
| » W: Eric Show (8-4) L: Bob Knepper (6-7) | Fifth | 9 out |
| Wednesday, June 20 |
| » Lost to Padres (39-26), 6-2 | Astrodome (18-16) | 30-37 | Lost 2 |
| » W: Tim Lollar (6-5) L: Mike Madden (2-2) S: Dave Dravecky (7) | Fifth | 10 out |
| Thursday, June 21 |
| » Defeated Padres (39-27), 11-5 | Astrodome (19-16) | 31-37 | |
| » W: Joe Niekro (6-7) L: Ed Whitson (7-4) S: Mike LaCoss (3) | Fifth | 9 out |
| Friday, June 22 |
| » Defeated Giants (25-42), 10-3 | Astrodome (20-16) | 32-37 | Won 2 |
| » W: Mike Scott (4-4) L: Mike Krukow (3-7) | Fifth | 8 out |
| Saturday, June 23 |
| » Lost to Giants (26-42), 7-5 | Astrodome (20-17) | 32-38 | |
| » W: Frank Williams (5-0) L: Vern Ruhle (1-5) S: Greg Minton (6) | Fifth | 9 out |
| Sunday, June 24 |
| » Defeated Giants (26-43), 8-3 | Astrodome (21-17) | 33-38 | |
| » W: Bob Knepper (7-7) L: Jeff Robinson (3-9) | Fourth | 9 out |
| Monday, June 25 |
| » Defeated Braves (39-34), 8-5 | Atlanta-Fulton County Stadium (3-1) | 34-38 | Won 2 |
| » W: Mike LaCoss (2-0) L: Len Barker (6-7) S: Frank DiPino (8) | Fourth | 9½ out |
| » Lost to Braves (40-34), 6-4 | Atlanta-Fulton County Stadium (3-2) | 34-39 | |
| » W: Rick Mahler (6-2) L: Mike Madden (2-3) S: Donnie Moore (5) | Fourth | 9½ out |
| Tuesday, June 26 |
| » Defeated Braves (40-35), 10-5 | Atlanta-Fulton County Stadium (4-2) | 35-39 | |
| » W: Joe Niekro (7-7) L: Rick Camp (3-1) | Fourth | 9½ out |
| Wednesday, June 27 |
| » Lost to Braves (41-35), 6-4 | Atlanta-Fulton County Stadium (4-3) | 35-40 | |
| » W: Pascual Perez (8-2) L: Mike Scott (4-5) S: Donnie Moore (6) | Fourth | 9½ out |
| Thursday, June 28 |
| » Defeated Phillies (41-33), 7-6 | Veteran's Stadium (1-2) | 36-40 | |
| » W: Bill Dawley (5-4) L: Al Holland (4-4) | Fourth | 9½ out |
| Friday, June 29 |
| » Lost to Phillies (42-33), 7-2 | Veteran's Stadium (1-3) | 36-41 | |
| » W: Steve Carlton (6-4) L: Bob Knepper (7-8) | Fourth | 9½ out |
| Saturday, June 30 |
| » Defeated Phillies (42-34), 7-0 | Veteran's Stadium (2-3) | 37-41 | |
| » W: Mike LaCoss (3-0) L: Charles Hudson (7-6) S: Dave Smith (3) | Fourth | 8½ out |
| Sunday, July 1 |
| » Defeated Phillies (42-35), 13-1 | Veteran's Stadium (3-3) | 38-41 | Won 2 |
| » W: Joe Niekro (8-7) L: Kevin Gross (4-3) | Fourth | 8½ out |
| Monday, July 2 |
| » Lost to Mets (41-33), 4-2 | Shea Stadium (2-2) | 38-42 | |
| » W: Dwight Gooden (7-5) L: Mike Scott (4-6) S: Jesse Orosco (15) | Fourth | 9½ out |
| Tuesday, July 3 |
| » Lost to Mets (42-33), 4-3 | Shea Stadium (2-3) | 38-43 | Lost 2 |
| » W: Bruce Berenyi (5-9) L: Nolan Ryan (7-3) S: Jesse Orosco (16) | Fourth | 9½ out |
| Wednesday, July 4 |
| » Defeated Mets (42-34), 10-5 | Shea Stadium (3-3) | 39-43 | |
| » W: Bob Knepper (8-8) L: Ed Lynch (7-5) S: Dave Smith (4) | Fourth | 8½ out |
| Thursday, July 5 |
| » Defeated Expos (39-41), 2-1 | Stade Olympique (1-1) | 40-43 | Won 2 |
| » W: Mike LaCoss (4-0) L: Bryn Smith (6-7) S: Bill Dawley (1) | Fourth | 8½ out |
| Friday, July 6 |
| » Defeated Expos (39-42), 8-2 | Stade Olympique (2-1) | 41-43 | Won 3 |
| » W: Joe Niekro (9-7) L: Steve Rogers (3-8) | Fourth | 9 out |
| » Lost to Expos (40-42), 7-5 | Stade Olympique (2-2) | 41-44 | |
| » W: Dan Schatzeder (3-2) L: Vern Ruhle (1-6) S: Bob James (3) | Fourth | 9 out |
| Saturday, July 7 |
| » Defeated Expos (40-43), 3-2 | Stade Olympique (3-2) | 42-44 | |
| » W: Frank DiPino (2-5) L: Bob James (2-4) | Fourth | 9 out |
| Sunday, July 8 |
| » Lost to Expos (41-43), 8-5 | Stade Olympique (3-3) | 42-45 | |
| » W: Bill Gullickson (5-6) L: Nolan Ryan (7-4) S: Gary Lucas (7) | Fourth | 9 out |
| Thursday, July 12 |
| » Lost to Phillies (46-39), 5-3 | Astrodome (21-18) | 42-46 | Lost 2 |
| » W: Steve Carlton (7-4) L: Joe Niekro (9-8) S: Al Holland (18) | Fourth | 10 out |
| Friday, July 13 |
| » Lost to Phillies (47-39), 7-3 | Astrodome (21-19) | 42-47 | Lost 3 |
| » W: Shane Rawley (4-4) L: Nolan Ryan (7-5) S: Larry Andersen (3) | Fourth | 10 out |
| Saturday, July 14 |
| » Lost to Phillies (48-39), 4-3 | Astrodome (21-20) | 42-48 | Lost 4 |
| » W: Jerry Koosman (10-7) L: Vern Ruhle (1-7) S: Al Holland (19) | Fourth | 10 out |
| Sunday, July 15 |
| » Defeated Phillies (48-40), 3-2 | Astrodome (22-20) | 43-48 | |
| » W: Frank DiPino (3-5) L: Don Carman (0-1) | Fourth | 10 out |
| Monday, July 16 |
| » Lost to Mets (51-35), 13-3 | Astrodome (22-21) | 43-49 | |
| » W: Sid Fernandez (1-0) L: Mike Scott (4-7) | Fourth | 11 out |
| Tuesday, July 17 |
| » Defeated Mets (51-36), 3-2 | Astrodome (23-21) | 44-49 | |
| » W: Frank DiPino (4-5) L: Doug Sisk (1-2) | Fourth | 11 out |
| Wednesday, July 18 |
| » Lost to Mets (52-36), 3-1 | Astrodome (23-22) | 44-50 | |
| » W: Walt Terrell (8-7) L: Nolan Ryan (7-6) S: Jesse Orosco (19) | Fourth | 11 out |
| Thursday, July 19 |
| » Defeated Expos (46-46), 3-2 | Astrodome (24-22) | 45-50 | |
| » W: Mike LaCoss (5-0) L: Gary Lucas (0-3) | Fourth | 10 out |
| Friday, July 20 |
| » Defeated Expos (46-47), 8-4 | Astrodome (25-22) | 46-50 | Won 2 |
| » W: Bob Knepper (9-8) L: Steve Rogers (3-10) S: Bill Dawley (2) | Fourth | 9½ out |
| Saturday, July 21 |
| » Lost to Expos (47-47), 4-2 | Astrodome (25-23) | 46-51 | |
| » W: David Palmer (4-3) L: Mike Scott (4-8) S: Bob James (6) | Fourth | 10½ out |
| Sunday, July 22 |
| » Defeated Expos (47-48), 6-1 | Astrodome (26-23) | 47-51 | |
| » W: Joe Niekro (10-8) L: Bryn Smith (8-8) | Fourth | 10 out |
| Tuesday, July 24 |
| » Defeated Giants (37-59), 10-3 | Candlestick Park (3-2) | 48-51 | Won 2 |
| » W: Nolan Ryan (8-6) L: Mark Davis (3-11) | Fourth | 9 out |
| Wednesday, July 25 |
| » Lost to Giants (38-59), 7-3 | Candlestick Park (3-3) | 48-52 | |
| » W: Jeff Robinson (6-11) L: Mike LaCoss (5-1) | Fourth | 10 out |
| Thursday, July 26 |
| » Lost to Giants (39-59), 3-2 | Candlestick Park (3-4) | 48-53 | Lost 2 |
| » W: Bill Laskey (6-9) L: Mike Scott (4-9) S: Frank Williams (3) | Fourth | 11 out |
| Friday, July 27 |
| » Lost to Padres (59-41), 7-3 | San Diego/Jack Murphy Stadium (0-4) | 48-54 | Lost 3 |
| » W: Ed Whitson (12-5) L: Vern Ruhle (1-8) S: Craig Lefferts (5) | Fourth | 12 out |
| Saturday, July 28 |
| » Defeated Padres (59-42), 3-1 | San Diego/Jack Murphy Stadium (1-4) | 49-54 | |
| » W: Joe Niekro (11-8) L: Andy Hawkins (5-4) | Fourth | 12 out |
| » Lost to Padres (60-42), 1-0 | San Diego/Jack Murphy Stadium (1-5) | 49-55 | |
| » W: Eric Show (11-6) L: Nolan Ryan (8-7) S: Rich Gossage (19) | Fourth | 12 out |
| Sunday, July 29 |
| » Lost to Padres (61-42), 9-0 | San Diego/Jack Murphy Stadium (1-6) | 49-56 | Lost 2 |
| » W: Tim Lollar (8-9) L: Mike LaCoss (5-2) | Fourth | 13 out |
| Monday, July 30 |
| » Defeated Braves (54-51), 4-3 | Astrodome (27-23) | 50-56 | |
| » W: Dave Smith (1-2) L: Donnie Moore (1-2) | Fourth | 13 out |
| Tuesday, July 31 |
| » Lost to Braves (55-51), 6-3 | Astrodome (27-24) | 50-57 | |
| » W: Jeff Dedmon (3-1) L: Frank DiPino (4-6) S: Donnie Moore (13) | Fourth | 14 out |
| Wednesday, August 1 |
| » Lost to Braves (56-51), 6-5 | Astrodome (27-25) | 50-58 | Lost 2 |
| » W: Pete Falcone (5-6) L: Julio Solano (0-1) S: Steve Bedrosian (11) | Fourth | 15 out |
| Friday, August 3 |
| » Defeated Padres (64-43), 6-2 | Astrodome (28-25) | 51-58 | |
| » W: Nolan Ryan (9-7) L: Eric Show (11-7) | Fourth | 14 out |
| Saturday, August 4 |
| » Lost to Padres (65-43), 5-2 | Astrodome (28-26) | 51-59 | |
| » W: Tim Lollar (9-9) L: Mike LaCoss (5-3) S: Craig Lefferts (6) | Fourth | 15 out |
| Sunday, August 5 |
| » Lost to Padres (66-43), 9-5 | Astrodome (28-27) | 51-60 | Lost 2 |
| » W: Andy Hawkins (6-4) L: Joe Niekro (11-9) | Fourth | 16 out |
| Monday, August 6 |
| » Defeated Giants (43-65), 8-0 | Astrodome (29-27) | 52-60 | |
| » W: Bob Knepper (10-8) L: Bill Laskey (6-10) | Fourth | 16 out |
| Tuesday, August 7 |
| » Lost to Giants (44-65), 9-2 | Astrodome (29-28) | 52-61 | |
| » W: Mike Krukow (10-8) L: Mike Scott (4-10) | Fourth | 16 out |
| Wednesday, August 8 |
| » Defeated Giants (44-66), 7-6 | Astrodome (30-28) | 53-61 | |
| » W: Bill Dawley (6-4) L: Mark Calvert (1-2) | Fourth | 15 out |
| Thursday, August 9 |
| » Defeated Giants (44-67), 6-0 | Astrodome (31-28) | 54-61 | Won 2 |
| » W: Mike LaCoss (6-3) L: Jeff Robinson (6-13) | Fourth | 14 out |
| Friday, August 10 |
| » Lost to Reds (50-65), 5-4 | Riverfront Stadium (0-3) | 54-62 | |
| » W: John Franco (4-0) L: Julio Solano (0-2) | Fourth | 14 out |
| » Defeated Reds (50-66), 11-7 | Riverfront Stadium (1-3) | 55-62 | |
| » W: Bob Knepper (11-8) L: Frank Pastore (3-7) S: Frank DiPino (9) | Fourth | 14 out |
| Saturday, August 11 |
| » Defeated Reds (50-67), 8-2 | Riverfront Stadium (2-3) | 56-62 | Won 2 |
| » W: Mike Scott (5-10) L: Joe Price (5-9) | Fourth | 14 out |
| Sunday, August 12 |
| » Defeated Reds (50-68), 6-1 | Riverfront Stadium (3-3) | 57-62 | Won 3 |
| » W: Nolan Ryan (10-7) L: Andy McGaffigan (3-5) | Fourth | 13 out |
| Monday, August 13 |
| » Defeated Cubs (70-48), 2-1 | Astrodome (32-28) | 58-62 | Won 4 |
| » W: Bill Dawley (7-4) L: Scott Sanderson (6-3) | Fourth | 12½ out |
| Tuesday, August 14 |
| » Defeated Cubs (70-49), 7-6 | Astrodome (33-28) | 59-62 | Won 5 |
| » W: Julio Solano (1-2) L: George Frazier (5-4) S: Frank DiPino (10) | Fourth | 12½ out |
| Wednesday, August 15 |
| » Defeated Cubs (70-50), 6-2 | Astrodome (34-28) | 60-62 | Won 6 |
| » W: Bob Knepper (12-8) L: Dennis Eckersley (10-11) S: Frank DiPino (11) | Fourth | 12½ out |
| Friday, August 17 |
| » Defeated Pirates (52-70), 7-4 | Three Rivers Stadium (2-2) | 61-62 | Won 7 |
| » W: Bill Dawley (8-4) L: Kent Tekulve (2-8) | Fourth | 11 out |
| Saturday, August 18 |
| » Defeated Pirates (52-71), 5-0 | Three Rivers Stadium (3-2) | 62-62 | Won 8 |
| » W: Mike LaCoss (7-3) L: Jose DeLeon (6-10) | Third | 10½ out |
| Sunday, August 19 |
| » Defeated Pirates (52-72), 4-3 | Three Rivers Stadium (4-2) | 63-62 | Won 9 |
| » W: Joe Niekro (12-9) L: John Candelaria (10-10) S: Bill Dawley (3) | Third | 9½ out |
| Monday, August 20 |
| » Lost to Cubs (73-51), 6-1 | Wrigley Field (0-4) | 63-63 | |
| » W: Steve Trout (11-5) L: Bob Knepper (12-9) | Third | 10½ out |
| Tuesday, August 21 |
| » Lost to Cubs (74-51), 11-5 | Wrigley Field (0-5) | 63-64 | Lost 2 |
| » W: Dennis Eckersley (11-11) L: Mike Scott (5-11) | Third | 11½ out |
| Wednesday, August 22 |
| » Defeated Cubs (74-52), 8-3 | Wrigley Field (1-5) | 64-64 | |
| » W: Nolan Ryan (11-7) L: Dick Ruthven (3-9) | Third | 10½ out |
| Thursday, August 23 |
| » Defeated Cardinals (63-63), 9-6 | Astrodome (35-28) | 65-64 | Won 2 |
| » W: Dave Smith (2-2) L: Dave Rucker (1-3) S: Frank DiPino (12) | Second | 10 out |
| Friday, August 24 |
| » Defeated Cardinals (63-64), 7-2 | Astrodome (36-28) | 66-64 | Won 3 |
| » W: Joe Niekro (13-9) L: Ricky Horton (8-3) | Second | 9½ out |
| Saturday, August 25 |
| » Defeated Cardinals (63-65), 5-2 | Astrodome (37-28) | 67-64 | Won 4 |
| » W: Bob Knepper (13-9) L: Dave LaPoint (9-10) | Second | 9½ out |
| Sunday, August 26 |
| » Lost to Cardinals (64-65), 3-2 | Astrodome (37-29) | 67-65 | |
| » W: Kurt Kepshire (4-3) L: Nolan Ryan (11-8) S: Bruce Sutter (35) | Second | 10½ out |
| Tuesday, August 28 |
| » Defeated Pirates (56-75), 3-2 | Astrodome (38-29) | 68-65 | |
| » W: Dave Smith (3-2) L: John Tudor (8-9) | Second | 9 out |
| Wednesday, August 29 |
| » Lost to Pirates (57-75), 4-2 | Astrodome (38-30) | 68-66 | |
| » W: Don Robinson (3-5) L: Frank DiPino (4-7) | Second | 10 out |
| Friday, August 31 |
| » Lost to Cardinals (67-65), 7-5 | Busch Stadium II (3-1) | 68-67 | Lost 2 |
| » W: Neil Allen (8-5) L: Nolan Ryan (11-9) S: Bruce Sutter (36) | Second | 10½ out |
| Saturday, September 1 |
| » Defeated Cardinals (67-66), 8-4 | Busch Stadium II (4-1) | 69-67 | |
| » W: Mark Ross (1-0) L: Kurt Kepshire (4-4) S: Dave Smith (5) | Second | 9 out |
| Sunday, September 2 |
| » Lost to Cardinals (68-66), 4-1 | Busch Stadium II (4-2) | 69-68 | |
| » W: Ricky Horton (9-3) L: Joe Niekro (13-10) S: Bruce Sutter (37) | Second | 9 out |
| » Major-league debuts: Jeff Calhoun and Glenn Davis (Astros) |
| Monday, September 3 |
| » Lost to Braves (67-70), 6-4 | Atlanta-Fulton County Stadium (4-4) | 69-69 | Lost 2 |
| » W: Craig McMurtry (9-14) L: Vern Ruhle (1-9) S: Gene Garber (7) | Second | 10 out |
| Tuesday, September 4 |
| » Lost to Braves (68-70), 8-7 | Atlanta-Fulton County Stadium (4-5) | 69-70 | Lost 3 |
| » W: Donnie Moore (4-3) L: Frank DiPino (4-8) | Second | 10 out |
| » Major-league debuts: Milt Thompson (Braves) |
| Wednesday, September 5 |
| » Defeated Giants (58-81), 4-1 | Candlestick Park (4-4) | 70-70 | |
| » W: Nolan Ryan (12-9) L: Randy Lerch (5-2) S: Bill Dawley (4) | Second | 10 out |
| Thursday, September 6 |
| » Defeated Giants (58-82), 14-2 | Candlestick Park (5-4) | 71-70 | Won 2 |
| » W: Bob Knepper (14-9) L: Bill Laskey (7-12) | Second | 9 out |
| Friday, September 7 |
| » Defeated Padres (80-62), 6-4 | San Diego/Jack Murphy Stadium (2-6) | 72-70 | Won 3 |
| » W: Joe Niekro (14-10) L: Tim Lollar (10-12) S: Frank DiPino (13) | Second | 8 out |
| Sunday, September 9 |
| » Lost to Padres (81-62), 8-4 | San Diego/Jack Murphy Stadium (2-7) | 72-71 | |
| » W: Mark Thurmond (13-7) L: Mike LaCoss (7-4) | Second | 9 out |
| Monday, September 10 |
| » Lost to Braves (70-74), 3-1 | Astrodome (38-31) | 72-72 | Lost 2 |
| » W: Zane Smith (1-0) L: Nolan Ryan (12-10) S: Pete Falcone (2) | Second | 9½ out |
| » Major-league debuts: Zane Smith (Braves) |
| Tuesday, September 11 |
| » Lost to Braves (71-74), 6-4 | Astrodome (38-32) | 72-73 | Lost 3 |
| » W: Rick Mahler (10-9) L: Julio Solano (1-3) S: Gene Garber (8) | Second | 9½ out |
| Wednesday, September 12 |
| » Lost to Braves (72-74), 4-1 | Astrodome (38-33) | 72-74 | Lost 4 |
| » W: Pascual Perez (12-6) L: Dave Smith (3-3) | Second | 9½ out |
| Friday, September 14 |
| » Lost to Padres (82-64), 4-2 | Astrodome (38-34) | 72-75 | Lost 5 |
| » W: Rich Gossage (9-5) L: Frank DiPino (4-9) | Second | 10½ out |
| Saturday, September 15 |
| » Defeated Padres (82-65), 3-2 | Astrodome (39-34) | 73-75 | |
| » W: Bill Dawley (9-4) L: Craig Lefferts (3-4) | Second | 9½ out |
| Sunday, September 16 |
| » Defeated Padres (82-66), 10-9 | Astrodome (40-34) | 74-75 | Won 2 |
| » W: Dave Smith (4-3) L: Rich Gossage (9-6) | Second | 8½ out |
| Monday, September 17 |
| » Defeated Giants (62-87), 5-3 | Astrodome (41-34) | 75-75 | Won 3 |
| » W: Joe Niekro (15-10) L: Mark Grant (1-4) S: Bill Dawley (5) | Second | 8½ out |
| Tuesday, September 18 |
| » Defeated Giants (62-88), 5-4 | Astrodome (42-34) | 76-75 | Won 4 |
| » W: Dave Smith (5-3) L: Scott Garrelts (1-2) | Second | 8½ out |
| Wednesday, September 19 |
| » Lost to Dodgers (74-78), 3-1 | Astrodome (42-35) | 76-76 | |
| » W: Jerry Reuss (4-7) L: Bob Knepper (14-10) | Second | 9½ out |
| Thursday, September 20 |
| » Lost to Dodgers (75-78), 6-2 | Astrodome (42-36) | 76-77 | Lost 2 |
| » W: Orel Hershiser (10-8) L: Nolan Ryan (12-11) | Second | 10½ out |
| Friday, September 21 |
| » Lost to Reds (65-89), 5-2 | Astrodome (42-37) | 76-78 | Lost 3 |
| » W: Mario Soto (16-7) L: Joe Niekro (15-11) S: Ted Power (10) | Third | 10½ out |
| Saturday, September 22 |
| » Lost to Reds (66-89), 2-1 | Astrodome (42-38) | 76-79 | Lost 4 |
| » W: Ted Power (9-6) L: Dave Smith (5-4) S: Carl Willis (1) | Third | 10½ out |
| Sunday, September 23 |
| » Defeated Reds (66-90), 2-1 | Astrodome (43-38) | 77-79 | |
| » W: Bob Knepper (15-10) L: Joe Price (7-13) | Third | 10½ out |
| Monday, September 24 |
| » Lost to Dodgers (76-81), 5-1 | Dodger Stadium (2-5) | 77-80 | |
| » |
