| Monday, April 2 |
| » Defeated Red Sox (0-1), 2-1 | Anaheim Stadium (1-0) | 1-0 | |
| » W: Ken Forsch (1-0) L: Bruce Hurst (0-1) | First | -- |
| Wednesday, April 4 |
| » Lost to Red Sox (1-1), 2-1 | Anaheim Stadium (1-1) | 1-1 | |
| » W: Mark Clear (1-0) L: Luis Sanchez (0-1) | Third | 1 out |
| Thursday, April 5 |
| » Lost to Red Sox (2-1), 7-4 | Anaheim Stadium (1-2) | 1-2 | Lost 2 |
| » W: Bob Stanley (1-0) L: Curt Kaufman (0-1) | Fifth | 1½ out |
| » Major-league debuts: Ron Romanick (Angels) |
| Friday, April 6 |
| » Lost to Blue Jays (2-1), 11-5 | Anaheim Stadium (1-3) | 1-3 | Lost 3 |
| » W: Jimmy Key (1-0) L: Steve Brown (0-1) | Sixth | 2½ out |
| » Major-league debuts: Jimmy Key (Blue Jays) |
| Saturday, April 7 |
| » Lost to Blue Jays (3-1), 3-1 | Anaheim Stadium (1-4) | 1-4 | Lost 4 |
| » W: Dave Stieb (1-0) L: Ken Forsch (1-1) S: Dennis Lamp (1) | Fourth | 2½ out |
| Sunday, April 8 |
| » Defeated Blue Jays (3-2), 4-3 | Anaheim Stadium (2-4) | 2-4 | |
| » W: Luis Sanchez (1-1) L: Roy Lee Jackson (0-1) | Fourth | 2½ out |
| Tuesday, April 10 |
| » Lost to Brewers (1-5), 10-1 | Anaheim Stadium (2-5) | 2-5 | |
| » W: Mike Caldwell (1-1) L: Mike Witt (0-1) | Sixth | 3½ out |
| Wednesday, April 11 |
| » Defeated Brewers (1-6), 9-5 | Anaheim Stadium (3-5) | 3-5 | |
| » W: Ron Romanick (1-0) L: Moose Haas (0-2) | Fifth | 3½ out |
| Thursday, April 12 |
| » Defeated Athletics (5-3), 3-2 | Oakland-Alameda County Stadium (1-0) | 4-5 | Won 2 |
| » W: Geoff Zahn (1-0) L: Mike Warren (0-2) S: Luis Sanchez (1) | Fifth | 3 out |
| Friday, April 13 |
| » Lost to Athletics (6-3), 2-1 | Oakland-Alameda County Stadium (1-1) | 4-6 | |
| » W: Bill Caudill (2-0) L: Tommy John (0-1) | Fifth | 3 out |
| Saturday, April 14 |
| » Lost to Athletics (7-3), 4-3 | Oakland-Alameda County Stadium (1-2) | 4-7 | Lost 2 |
| » W: Bill Caudill (3-0) L: Curt Kaufman (0-2) | Fifth | 3½ out |
| Sunday, April 15 |
| » Defeated Athletics (7-4), 12-8 | Oakland-Alameda County Stadium (2-2) | 5-7 | |
| » W: Mike Witt (1-1) L: Lary Sorensen (1-2) S: Doug Corbett (1) | Sixth | 3 out |
| Monday, April 16 |
| » Lost to Twins (7-4), 9-2 | Hubert H. Humphrey Metrodome (0-1) | 5-8 | |
| » W: Mike Smithson (3-0) L: Ron Romanick (1-1) | Fifth | 3½ out |
| Tuesday, April 17 |
| » Defeated Twins (7-5), 6-3 | Hubert H. Humphrey Metrodome (1-1) | 6-8 | |
| » W: Tommy John (1-1) L: John Butcher (1-1) S: Luis Sanchez (2) | Fifth | 3½ out |
| Wednesday, April 18 |
| » Defeated Twins (7-6), 9-2 | Hubert H. Humphrey Metrodome (2-1) | 7-8 | Won 2 |
| » W: Geoff Zahn (2-0) L: Albert Williams (1-2) | Fourth | 2½ out |
| Friday, April 20 |
| » Defeated Blue Jays (9-5), 10-6 | Exhibition Stadium (1-0) | 8-8 | Won 3 |
| » W: Luis Sanchez (2-1) L: Jim Acker (0-1) | Fifth | 2 out |
| » Major-league debuts: Kelly Gruber (Blue Jays) |
| Saturday, April 21 |
| » Defeated Blue Jays (9-6), 8-4 | Exhibition Stadium (2-0) | 9-8 | Won 4 |
| » W: Ron Romanick (2-1) L: Jim Gott (0-1) | Third | 1½ out |
| Sunday, April 22 |
| » Defeated Blue Jays (9-7), 9-6 | Exhibition Stadium (3-0) | 10-8 | Won 5 |
| » W: Jim Slaton (1-0) L: Jimmy Key (2-1) S: Curt Kaufman (1) | Third | 1½ out |
| Monday, April 23 |
| » Lost to Red Sox (6-10), 2-0 | Fenway Park (0-1) | 10-9 | |
| » W: Bob Ojeda (1-2) L: Geoff Zahn (2-1) | Third | 1 out |
| Tuesday, April 24 |
| » Defeated Red Sox (6-11), 8-7 | Fenway Park (1-1) | 11-9 | |
| » W: Luis Sanchez (3-1) L: Bob Stanley (1-1) | Third | 1½ out |
| Wednesday, April 25 |
| » Defeated Brewers (6-10), 5-1 | County Stadium (1-0) | 12-9 | Won 2 |
| » W: Mike Witt (2-1) L: Jaime Cocanower (0-3) | First | -- |
| Thursday, April 26 |
| » Lost to Brewers (7-10), 2-1 | County Stadium (1-1) | 12-10 | |
| » W: Don Sutton (2-2) L: Tommy John (1-2) S: Rollie Fingers (3) | Third | 1½ out |
| Friday, April 27 |
| » Defeated Mariners (11-9), 9-3 | Anaheim Stadium (4-5) | 13-10 | |
| » W: Ron Romanick (3-1) L: Bob Stoddard (0-2) | Second | 1 out |
| Saturday, April 28 |
| » Defeated Mariners (11-10), 10-1 | Anaheim Stadium (5-5) | 14-10 | Won 2 |
| » W: Geoff Zahn (3-1) L: Mark Langston (1-2) | Second | 1 out |
| Sunday, April 29 |
| » Lost to Mariners (12-10), 9-6 | Anaheim Stadium (5-6) | 14-11 | |
| » W: Roy Thomas (2-0) L: Frank LaCorte (0-1) | Second | ½ out |
| Monday, April 30 |
| » Defeated Mariners (12-11), 8-1 | Anaheim Stadium (6-6) | 15-11 | |
| » W: Mike Witt (3-1) L: Paul Mirabella (1-1) | Second | 1 out |
| Tuesday, May 1 |
| » Defeated Athletics (14-11), 4-1 | Anaheim Stadium (7-6) | 16-11 | Won 2 |
| » W: Tommy John (2-2) L: Mike Warren (3-3) S: Luis Sanchez (3) | First | -- |
| Wednesday, May 2 |
| » Lost to Athletics (15-11), 7-6 | Anaheim Stadium (7-7) | 16-12 | |
| » W: Keith Atherton (1-1) L: Ron Romanick (3-2) S: Bill Caudill (6) | Second | 1 out |
| Friday, May 4 |
| » Defeated Mariners (14-13), 4-1 | Kingdome (1-0) | 17-12 | |
| » W: Geoff Zahn (4-1) L: Mike Moore (1-2) | First | -- |
| Saturday, May 5 |
| » Defeated Mariners (14-14), 3-1 | Kingdome (2-0) | 18-12 | Won 2 |
| » W: Mike Witt (4-1) L: Jim Beattie (2-3) | First | -- |
| Sunday, May 6 |
| » Lost to Mariners (15-14), 3-1 | Kingdome (2-1) | 18-13 | |
| » W: Ed Vande Berg (2-1) L: Tommy John (2-3) S: Dave Beard (4) | First | -- |
| Monday, May 7 |
| » Lost to Twins (16-15), 11-1 | Anaheim Stadium (7-8) | 18-14 | Lost 2 |
| » W: Mike Smithson (4-3) L: Ron Romanick (3-3) | First | -- |
| Tuesday, May 8 |
| » Lost to Twins (17-15), 5-0 | Anaheim Stadium (7-9) | 18-15 | Lost 3 |
| » W: Frank Viola (3-3) L: Jim Slaton (1-1) | Second | 1 out |
| » Major-league debuts: Kirby Puckett (Twins) |
| Wednesday, May 9 |
| » Lost to Twins (18-15), 5-2 | Anaheim Stadium (7-10) | 18-16 | Lost 4 |
| » W: Pete Filson (3-0) L: Geoff Zahn (4-2) | Third | ½ out |
| Friday, May 11 |
| » Lost to Tigers (26-4), 8-2 | Tiger Stadium (0-1) | 18-17 | Lost 5 |
| » W: Milt Wilcox (4-0) L: Mike Witt (4-2) S: Willie Hernandez (4) | Third | ½ out |
| Saturday, May 12 |
| » Defeated Tigers (26-5), 4-2 | Tiger Stadium (1-1) | 19-17 | |
| » W: Tommy John (3-3) L: Juan Berenguer (2-2) | Third | ½ out |
| Sunday, May 13 |
| » Major-league debuts: Daryl Boston (White Sox) |
| Monday, May 14 |
| » Lost to Orioles (19-16), 4-1 | Memorial Stadium (0-1) | 19-18 | |
| » W: Scott McGregor (5-3) L: Geoff Zahn (4-3) | Second | ½ out |
| Tuesday, May 15 |
| » Defeated Orioles (19-17), 5-2 | Memorial Stadium (1-1) | 20-18 | |
| » W: Ron Romanick (4-3) L: Mike Flanagan (2-3) S: Luis Sanchez (4) | First | -- |
| Wednesday, May 16 |
| » Lost to Orioles (20-17), 5-0 | Memorial Stadium (1-2) | 20-19 | |
| » W: Mike Boddicker (4-3) L: Mike Witt (4-3) | First | -- |
| Friday, May 18 |
| » Defeated Yankees (16-20), 4-3 | Yankee Stadium (1-0) | 21-19 | |
| » W: Luis Sanchez (4-1) L: Jay Howell (1-2) | First | -- |
| Saturday, May 19 |
| » Defeated Yankees (16-21), 4-0 | Yankee Stadium (2-0) | 22-19 | Won 2 |
| » W: Geoff Zahn (5-3) L: Phil Niekro (6-2) | First | -- |
| Sunday, May 20 |
| » Defeated Yankees (16-22), 3-0 | Yankee Stadium (3-0) | 23-19 | Won 3 |
| » W: Ron Romanick (5-3) L: Ron Guidry (2-3) | First | -- |
| Tuesday, May 22 |
| » Lost to Tigers (33-5), 3-1 | Anaheim Stadium (7-11) | 23-20 | |
| » W: Juan Berenguer (3-2) L: Mike Witt (4-4) S: Aurelio Lopez (6) | First | -- |
| Wednesday, May 23 |
| » Lost to Tigers (34-5), 4-2 | Anaheim Stadium (7-12) | 23-21 | Lost 2 |
| » W: Dan Petry (7-1) L: Frank LaCorte (0-2) S: Willie Hernandez (7) | First | -- |
| Thursday, May 24 |
| » Lost to Tigers (35-5), 5-1 | Anaheim Stadium (7-13) | 23-22 | Lost 3 |
| » W: Jack Morris (9-1) L: Jim Slaton (1-2) | First | -- |
| Friday, May 25 |
| » Defeated Orioles (23-21), 10-2 | Anaheim Stadium (8-13) | 24-22 | |
| » W: Ron Romanick (6-3) L: Mike Flanagan (3-4) | First | -- |
| Saturday, May 26 |
| » Lost to Orioles (24-21), 9-5 | Anaheim Stadium (8-14) | 24-23 | |
| » W: Mike Boddicker (5-4) L: Craig Swan (1-1) | First | -- |
| Sunday, May 27 |
| » Lost to Orioles (25-21), 8-0 | Anaheim Stadium (8-15) | 24-24 | Lost 2 |
| » W: Scott McGregor (6-3) L: Mike Witt (4-5) | First | -- |
| Monday, May 28 |
| » Defeated Yankees (19-26), 6-2 | Anaheim Stadium (9-15) | 25-24 | |
| » W: Doug Corbett (1-0) L: Dennis Rasmussen (1-1) | First | -- |
| Tuesday, May 29 |
| » Defeated Yankees (19-27), 6-5 | Anaheim Stadium (10-15) | 26-24 | Won 2 |
| » W: Frank LaCorte (1-2) L: Phil Niekro (7-3) S: Luis Sanchez (5) | First | -- |
| Wednesday, May 30 |
| » Lost to Yankees (20-27), 10-1 | Anaheim Stadium (10-16) | 26-25 | |
| » W: Ron Guidry (3-4) L: Ron Romanick (6-4) | First | -- |
| Friday, June 1 |
| » Defeated Indians (17-29), 5-2 | Cleveland Stadium (1-0) | 27-25 | |
| » W: Mike Witt (5-5) L: Rick Sutcliffe (3-5) S: Doug Corbett (2) | First | -- |
| Saturday, June 2 |
| » Defeated Indians (17-30), 6-4 | Cleveland Stadium (2-0) | 28-25 | Won 2 |
| » W: Luis Sanchez (5-1) L: Ernie Camacho (1-5) | First | -- |
| Sunday, June 3 |
| » Defeated Indians (17-31), 7-4 | Cleveland Stadium (3-0) | 29-25 | Won 3 |
| » W: Curt Kaufman (1-2) L: Dan Spillner (0-5) | First | -- |
| Monday, June 4 |
| » Lost to White Sox (25-27), 6-4 | Comiskey Park I (0-1) | 29-26 | |
| » W: La Marr Hoyt (5-5) L: Ron Romanick (6-5) S: Al Jones (3) | First | -- |
| Tuesday, June 5 |
| » Defeated White Sox (25-28), 6-1 | Comiskey Park I (1-1) | 30-26 | |
| » W: Geoff Zahn (6-3) L: Britt Burns (2-5) | First | -- |
| Wednesday, June 6 |
| » Lost to White Sox (26-28), 4-0 | Comiskey Park I (1-2) | 30-27 | |
| » W: Tom Seaver (5-4) L: Mike Witt (5-6) | First | -- |
| Thursday, June 7 |
| » Lost to White Sox (27-28), 11-10 | Comiskey Park I (1-3) | 30-28 | Lost 2 |
| » W: Bert Roberge (2-0) L: Tommy John (3-4) S: Al Jones (4) | First | -- |
| Saturday, June 9 |
| » Defeated Royals (26-28), 4-1 | Royals Stadium (1-0) | 31-28 | |
| » W: Ron Romanick (7-5) L: Bud Black (6-4) S: Luis Sanchez (6) | First | -- |
| Sunday, June 10 |
| » Defeated Royals (26-29), 2-0 | Royals Stadium (2-0) | 32-28 | Won 2 |
| » W: Geoff Zahn (7-3) L: Mark Gubicza (3-5) | First | -- |
| Tuesday, June 12 |
| » Defeated White Sox (29-30), 3-2 | Anaheim Stadium (11-16) | 33-28 | Won 3 |
| » W: Doug Corbett (2-0) L: Al Jones (0-1) | First | -- |
| Wednesday, June 13 |
| » Lost to White Sox (30-30), 2-1 | Anaheim Stadium (11-17) | 33-29 | |
| » W: Richard Dotson (8-3) L: Tommy John (3-5) | First | -- |
| Thursday, June 14 |
| » Defeated White Sox (30-31), 9-3 | Anaheim Stadium (12-17) | 34-29 | |
| » W: Ron Romanick (8-5) L: Britt Burns (2-7) S: Doug Corbett (3) | First | -- |
| Friday, June 15 |
| » Defeated Indians (22-37), 5-2 | Anaheim Stadium (13-17) | 35-29 | Won 2 |
| » W: Geoff Zahn (8-3) L: Neal Heaton (4-6) S: Luis Sanchez (7) | First | -- |
| Saturday, June 16 |
| » Defeated Indians (22-38), 7-2 | Anaheim Stadium (14-17) | 36-29 | Won 3 |
| » W: Jim Slaton (2-2) L: Steve Farr (0-4) S: Bruce Kison (1) | First | -- |
| Sunday, June 17 |
| » Lost to Indians (23-38), 4-3 | Anaheim Stadium (14-18) | 36-30 | |
| » W: Ernie Camacho (2-7) L: Mike Witt (5-7) | First | -- |
| Monday, June 18 |
| » Lost to Rangers (29-38), 6-2 | Anaheim Stadium (14-19) | 36-31 | Lost 2 |
| » W: Frank Tanana (8-6) L: Tommy John (3-6) | First | -- |
| Tuesday, June 19 |
| » Lost to Rangers (30-38), 4-2 | Anaheim Stadium (14-20) | 36-32 | Lost 3 |
| » W: Dave Stewart (4-8) L: Ron Romanick (8-6) S: Odell Jones (2) | First | -- |
| Wednesday, June 20 |
| » Lost to Rangers (31-38), 3-2 | Anaheim Stadium (14-21) | 36-33 | Lost 4 |
| » W: Charlie Hough (7-6) L: Geoff Zahn (8-4) | First | -- |
| Friday, June 22 |
| » Defeated Royals (28-37), 8-1 | Anaheim Stadium (15-21) | 37-33 | |
| » W: Mike Witt (6-7) L: Charlie Leibrandt (2-2) | First | -- |
| Saturday, June 23 |
| » Lost to Royals (29-37), 6-5 | Anaheim Stadium (15-22) | 37-34 | |
| » W: Larry Gura (8-3) L: Bruce Kison (0-1) S: Dan Quisenberry (18) | First | -- |
| Sunday, June 24 |
| » Lost to Royals (30-37), 3-2 | Anaheim Stadium (15-23) | 37-35 | Lost 2 |
| » W: Bud Black (8-5) L: Ron Romanick (8-7) S: Dan Quisenberry (19) | First | -- |
| Monday, June 25 |
| » Lost to Rangers (33-40), 5-4 | Arlington Stadium (0-1) | 37-36 | Lost 3 |
| » W: Dave Schmidt (2-3) L: Doug Corbett (2-1) | First | -- |
| Tuesday, June 26 |
| » Defeated Rangers (33-41), 3-2 | Arlington Stadium (1-1) | 38-36 | |
| » W: Bruce Kison (1-1) L: Odell Jones (1-3) | First | -- |
| Wednesday, June 27 |
| » Defeated Rangers (33-42), 2-1 | Arlington Stadium (2-1) | 39-36 | Won 2 |
| » W: Mike Witt (7-7) L: Mike Mason (5-5) S: Luis Sanchez (8) | First | -- |
| Thursday, June 28 |
| » Defeated Brewers (33-41), 7-3 | County Stadium (2-1) | 40-36 | Won 3 |
| » W: Tommy John (4-6) L: Bob Gibson (0-2) S: Doug Corbett (4) | First | -- |
| Friday, June 29 |
| » Lost to Brewers (34-41), 1-0 | County Stadium (2-2) | 40-37 | |
| » W: Moose Haas (5-6) L: Ron Romanick (8-8) S: Rollie Fingers (15) | First | -- |
| Saturday, June 30 |
| » Defeated Brewers (34-42), 2-0 | County Stadium (3-2) | 41-37 | |
| » W: Geoff Zahn (9-4) L: Jaime Cocanower (6-7) | First | -- |
| Sunday, July 1 |
| » Defeated Brewers (34-43), 7-6 | County Stadium (4-2) | 42-37 | Won 2 |
| » W: Bruce Kison (2-1) L: Bob McClure (2-4) S: Luis Sanchez (9) | First | -- |
| Monday, July 2 |
| » Defeated Blue Jays (46-32), 6-3 | Exhibition Stadium (4-0) | 43-37 | Won 3 |
| » W: Mike Witt (8-7) L: Jim Clancy (6-9) S: Don Aase (1) | First | -- |
| Tuesday, July 3 |
| » Lost to Blue Jays (47-32), 4-0 | Exhibition Stadium (4-1) | 43-38 | |
| » W: Jim Gott (5-2) L: Tommy John (4-7) | First | -- |
| Wednesday, July 4 |
| » Lost to Blue Jays (48-32), 6-3 | Exhibition Stadium (4-2) | 43-39 | Lost 2 |
| » W: Dave Stieb (9-3) L: Ron Romanick (8-9) | First | -- |
| Thursday, July 5 |
| » Lost to Red Sox (39-42), 12-7 | Fenway Park (1-2) | 43-40 | Lost 3 |
| » W: Oil Can Boyd (3-6) L: Geoff Zahn (9-5) S: Bob Stanley (14) | First | -- |
| Friday, July 6 |
| » Lost to Red Sox (40-42), 8-7 | Fenway Park (1-3) | 43-41 | Lost 4 |
| » W: Al Nipper (2-3) L: Jim Slaton (2-3) S: Mark Clear (2) | First | -- |
| Sunday, July 8 |
| » Lost to Red Sox (41-42), 3-2 | Fenway Park (1-4) | 43-42 | Lost 5 |
| » W: Bob Stanley (5-6) L: Luis Sanchez (5-2) | Second | 1 out |
| » Defeated Red Sox (41-43), 4-0 | Fenway Park (2-4) | 44-42 | |
| » W: Tommy John (5-7) L: Roger Clemens (3-3) | Second | 1 out |
| Thursday, July 12 |
| » Defeated Brewers (39-48), 5-2 | Anaheim Stadium (16-23) | 45-42 | Won 2 |
| » W: Mike Witt (9-7) L: Jaime Cocanower (7-8) | Second | 1 out |
| Friday, July 13 |
| » Lost to Brewers (40-48), 5-4 | Anaheim Stadium (16-24) | 45-43 | |
| » W: Don Sutton (7-8) L: Geoff Zahn (9-6) S: Rollie Fingers (19) | Second | 1 out |
| Saturday, July 14 |
| » Defeated Brewers (40-49), 2-1 | Anaheim Stadium (17-24) | 46-43 | |
| » W: Ron Romanick (9-9) L: Tom Tellmann (3-2) | First | -- |
| Sunday, July 15 |
| » Defeated Brewers (40-50), 7-6 | Anaheim Stadium (18-24) | 47-43 | Won 2 |
| » W: Luis Sanchez (6-2) L: Bob McClure (2-5) | First | -- |
| Monday, July 16 |
| » Defeated Blue Jays (53-36), 3-0 | Anaheim Stadium (19-24) | 48-43 | Won 3 |
| » W: Jim Slaton (3-3) L: Jim Gott (5-4) | First | -- |
| Tuesday, July 17 |
| » Defeated Blue Jays (53-37), 5-3 | Anaheim Stadium (20-24) | 49-43 | Won 4 |
| » W: Mike Witt (10-7) L: Jim Acker (2-5) S: Don Aase (2) | First | -- |
| Wednesday, July 18 |
| » Lost to Blue Jays (54-37), 8-2 | Anaheim Stadium (20-25) | 49-44 | |
| » W: Luis Leal (11-2) L: Geoff Zahn (9-7) | First | -- |
| Friday, July 20 |
| » Lost to Red Sox (46-46), 4-3 | Anaheim Stadium (20-26) | 49-45 | Lost 2 |
| » W: Bob Stanley (6-6) L: Don Aase (0-1) | First | -- |
| Saturday, July 21 |
| » Lost to Red Sox (47-46), 16-4 | Anaheim Stadium (20-27) | 49-46 | Lost 3 |
| » W: Bruce Hurst (10-5) L: Tommy John (5-8) | First | -- |
| Sunday, July 22 |
| » Lost to Red Sox (48-46), 3-0 | Anaheim Stadium (20-28) | 49-47 | Lost 4 |
| » W: Bob Ojeda (8-7) L: Jim Slaton (3-4) | First | -- |
| Monday, July 23 |
| » Defeated Mariners (45-55), 7-1 | Anaheim Stadium (21-28) | 50-47 | |
| » W: Mike Witt (11-7) L: Mike Moore (4-9) | First | -- |
| Tuesday, July 24 |
| » Lost to Mariners (46-55), 4-3 | Anaheim Stadium (21-29) | 50-48 | |
| » W: Ed Vande Berg (7-9) L: Geoff Zahn (9-8) S: Mike Stanton (8) | First | -- |
| Wednesday, July 25 |
| » Defeated Mariners (46-56), 1-0 | Anaheim Stadium (22-29) | 51-48 | |
| » W: Luis Sanchez (7-2) L: Jim Beattie (9-10) | First | -- |
| Friday, July 27 |
| » Lost to Twins (50-49), 2-0 | Hubert H. Humphrey Metrodome (2-2) | 51-49 | |
| » W: Mike Smithson (11-8) L: Tommy John (5-9) S: Ron Davis (19) | First | -- |
| Saturday, July 28 |
| » Lost to Twins (51-49), 6-1 | Hubert H. Humphrey Metrodome (2-3) | 51-50 | Lost 2 |
| » W: Frank Viola (11-9) L: Jim Slaton (3-5) | Second | ½ out |
| Sunday, July 29 |
| » Lost to Twins (52-49), 6-5 | Hubert H. Humphrey Metrodome (2-4) | 51-51 | Lost 3 |
| » W: Rick Lysander (1-1) L: Luis Sanchez (7-3) | Second | 1½ out |
| Monday, July 30 |
| » Defeated Athletics (48-58), 5-4 | Oakland-Alameda County Stadium (3-2) | 52-51 | |
| » W: Doug Corbett (3-1) L: Bill Caudill (8-4) S: Luis Sanchez (10) | Second | 1½ out |
| Tuesday, July 31 |
| » Defeated Athletics (48-59), 7-3 | Oakland-Alameda County Stadium (4-2) | 53-51 | Won 2 |
| » W: Ron Romanick (10-9) L: Lary Sorensen (3-11) | Second | 1½ out |
| Wednesday, August 1 |
| » Defeated Athletics (48-60), 6-4 | Oakland-Alameda County Stadium (5-2) | 54-51 | Won 3 |
| » W: Tommy John (6-9) L: Bill Krueger (7-8) | Second | ½ out |
| Thursday, August 2 |
| » Defeated Twins (54-51), 14-2 | Anaheim Stadium (23-29) | 55-51 | Won 4 |
| » W: Jim Slaton (4-5) L: Frank Viola (11-10) | First | -- |
| Friday, August 3 |
| » Lost to Twins (55-51), 4-2 | Anaheim Stadium (23-30) | 55-52 | |
| » W: John Butcher (9-6) L: Mike Witt (11-8) S: Ron Davis (20) | Second | ½ out |
| Saturday, August 4 |
| » Defeated Twins (55-52), 4-2 | Anaheim Stadium (24-30) | 56-52 | |
| » W: Geoff Zahn (10-8) L: Pete Filson (6-3) S: Bruce Kison (2) | First | -- |
| Sunday, August 5 |
| » Lost to Twins (56-52), 4-2 | Anaheim Stadium (24-31) | 56-53 | |
| » W: Ken Schrom (4-5) L: Ron Romanick (10-10) S: Ron Davis (21) | Second | ½ out |
| Monday, August 6 |
| » Defeated Mariners (50-63), 8-4 | Kingdome (3-1) | 57-53 | |
| » W: Tommy John (7-9) L: Salome Barojas (7-4) | Second | ½ out |
| Tuesday, August 7 |
| » Defeated Mariners (50-64), 7-6 | Kingdome (4-1) | 58-53 | Won 2 |
| » W: Don Aase (1-1) L: Mike Stanton (3-2) | Second | ½ out |
| Wednesday, August 8 |
| » Lost to Mariners (51-64), 7-2 | Kingdome (4-2) | 58-54 | |
| » W: Mark Langston (10-9) L: Mike Witt (11-9) S: Edwin Nunez (1) | Second | ½ out |
| Thursday, August 9 |
| » Lost to Athletics (54-62), 5-4 | Anaheim Stadium (24-32) | 58-55 | Lost 2 |
| » W: Curt Young (5-1) L: Geoff Zahn (10-9) S: Bill Caudill (26) | Second | ½ out |
| Friday, August 10 |
| » Lost to Athletics (55-62), 7-6 | Anaheim Stadium (24-33) | 58-56 | Lost 3 |
| » W: Keith Atherton (6-5) L: Luis Sanchez (7-4) S: Bill Caudill (27) | Second | 1½ out |
| Saturday, August 11 |
| » Lost to Athletics (56-62), 3-2 | Anaheim Stadium (24-34) | 58-57 | Lost 4 |
| » W: Tom Burgmeier (2-0) L: Luis Sanchez (7-5) | Second | 1½ out |
| Sunday, August 12 |
| » Defeated Athletics (56-63), 10-9 | Anaheim Stadium (25-34) | 59-57 | |
| » W: Luis Sanchez (8-5) L: Bill Caudill (8-5) | Second | 1½ out |
| Tuesday, August 14 |
| » Defeated Tigers (77-42), 6-4 | Tiger Stadium (2-1) | 60-57 | Won 2 |
| » W: Don Aase (2-1) L: Willie Hernandez (6-2) S: Luis Sanchez (11) | Second | 1½ out |
| » Defeated Tigers (77-43), 12-1 | Tiger Stadium (3-1) | 61-57 | Won 3 |
| » W: Bruce Kison (3-1) L: Dave Rozema (7-4) | Second | 1½ out |
| Wednesday, August 15 |
| » Lost to Tigers (78-43), 8-3 | Tiger Stadium (3-2) | 61-58 | |
| » W: Dan Petry (15-5) L: Tommy John (7-10) | Second | 1½ out |
| Thursday, August 16 |
| » Lost to Tigers (79-43), 8-7 | Tiger Stadium (3-3) | 61-59 | Lost 2 |
| » W: Willie Hernandez (7-2) L: John Curtis (0-1) | Second | 1½ out |
| Friday, August 17 |
| » Lost to Orioles (63-58), 6-5 | Memorial Stadium (1-3) | 61-60 | Lost 3 |
| » W: Scott McGregor (14-11) L: Jim Slaton (4-6) S: Sammy Stewart (7) | Second | 2½ out |
| Saturday, August 18 |
| » Lost to Orioles (64-58), 1-0 | Memorial Stadium (1-4) | 61-61 | Lost 4 |
| » W: Mike Boddicker (15-8) L: Mike Witt (11-10) | Second | 4 out |
| Sunday, August 19 |
| » Lost to Orioles (65-58), 10-4 | Memorial Stadium (1-5) | 61-62 | Lost 5 |
| » W: Mike Flanagan (10-11) L: Bruce Kison (3-2) | Second | 4 out |
| Monday, August 20 |
| » Lost to Yankees (65-59), 8-4 | Yankee Stadium (3-1) | 61-63 | Lost 6 |
| » W: Joe Cowley (5-1) L: Tommy John (7-11) | Second | 4½ out |
| Tuesday, August 21 |
| » Lost to Yankees (66-59), 8-2 | Yankee Stadium (3-2) | 61-64 | Lost 7 |
| » W: Phil Niekro (15-7) L: Ron Romanick (10-11) | Second | 5 out |
| Wednesday, August 22 |
| » Defeated Yankees (66-60), 2-1 | Yankee Stadium (4-2) | 62-64 | |
| » W: Jim Slaton (5-6) L: Ray Fontenot (6-8) S: Don Aase (3) | Second | 5½ out |
| Friday, August 24 |
| » Defeated Tigers (84-45), 5-3 | Anaheim Stadium (26-34) | 63-64 | Won 2 |
| » W: Mike Witt (12-10) L: Dan Petry (15-7) S: Don Aase (4) | Second | 4 out |
| Saturday, August 25 |
| » Lost to Tigers (85-45), 5-1 | Anaheim Stadium (26-35) | 63-65 | |
| » W: Jack Morris (17-8) L: Bruce Kison (3-3) | Second | 5 out |
| Sunday, August 26 |
| » Lost to Tigers (86-45), 12-6 | Anaheim Stadium (26-36) | 63-66 | Lost 2 |
| » W: Milt Wilcox (15-7) L: Tommy John (7-12) | Third | 5 out |
| Monday, August 27 |
| » Lost to Orioles (71-59), 7-6 | Anaheim Stadium (26-37) | 63-67 | Lost 3 |
| » W: Sammy Stewart (5-2) L: Luis Sanchez (8-6) | Third | 5 out |
| Tuesday, August 28 |
| » Defeated Orioles (71-60), 4-2 | Anaheim Stadium (27-37) | 64-67 | |
| » W: Jim Slaton (6-6) L: Scott McGregor (15-12) S: Don Aase (5) | Third | 5 out |
| Wednesday, August 29 |
| » Defeated Orioles (71-61), 7-5 | Anaheim Stadium (28-37) | 65-67 | Won 2 |
| » W: Doug Corbett (4-1) L: Mike Boddicker (16-9) | Third | 4 out |
| Friday, August 31 |
| » Defeated Yankees (71-62), 4-3 | Anaheim Stadium (29-37) | 66-67 | Won 3 |
| » W: John Curtis (1-1) L: Mike Armstrong (3-1) S: Don Aase (6) | Third | 2½ out |
| Saturday, September 1 |
| » Defeated Yankees (71-63), 11-6 | Anaheim Stadium (30-37) | 67-67 | Won 4 |
| » W: Doug Corbett (5-1) L: Dave Righetti (4-5) | Second | 1½ out |
| Sunday, September 2 |
| » Lost to Yankees (72-63), 5-3 | Anaheim Stadium (30-38) | 67-68 | |
| » W: Jay Howell (7-4) L: John Curtis (1-2) S: Dave Righetti (23) | Third | 1½ out |
| Monday, September 3 |
| » Lost to Indians (62-77), 6-5 | Cleveland Stadium (3-1) | 67-69 | Lost 2 |
| » W: Steve Comer (4-8) L: Jim Slaton (6-7) S: Jamie Easterly (2) | Third | 2½ out |
| Tuesday, September 4 |
| » Defeated Indians (62-78), 5-3 | Cleveland Stadium (4-1) | 68-69 | |
| » W: Don Aase (3-1) L: Jamie Easterly (2-1) | Third | 1½ out |
| Wednesday, September 5 |
| » Defeated Indians (62-79), 11-4 | Cleveland Stadium (5-1) | 69-69 | Won 2 |
| » W: Bruce Kison (4-3) L: Jose Roman (0-1) | Second | ½ out |
| » Major-league debuts: Jose Roman (Indians) |
| Friday, September 7 |
| » Defeated White Sox (65-75), 16-8 | Comiskey Park I (2-3) | 70-69 | Won 3 |
| » W: Geoff Zahn (11-9) L: Britt Burns (2-11) | Second | ½ out |
| Saturday, September 8 |
| » Defeated White Sox (65-76), 6-5 | Comiskey Park I (3-3) | 71-69 | Won 4 |
| » W: Luis Sanchez (9-6) L: Ron Reed (0-6) | Second | ½ out |
| Sunday, September 9 |
| » Lost to White Sox (66-76), 8-2 | Comiskey Park I (3-4) | 71-70 | |
| » W: Tom Seaver (14-9) L: Mike Witt (12-11) | Third | 1½ out |
| Tuesday, September 11 |
| » Lost to Indians (65-80), 4-2 | Anaheim Stadium (30-39) | 71-71 | Lost 2 |
| » W: Don Schulze (3-5) L: Ron Romanick (10-12) | Third | 2 out |
| Wednesday, September 12 |
| » Lost to Indians (66-80), 7-1 | Anaheim Stadium (30-40) | 71-72 | Lost 3 |
| » W: Bert Blyleven (17-6) L: Bruce Kison (4-4) | Second | 2 out |
| Thursday, September 13 |
| » Defeated Indians (66-81), 7-3 | Anaheim Stadium (31-40) | 72-72 | |
| » W: Jim Slaton (7-7) L: Jose Roman (0-2) S: Don Aase (7) | Second | 1½ out |
| Friday, September 14 |
| » Defeated White Sox (67-79), 5-0 | Anaheim Stadium (32-40) | 73-72 | Won 2 |
| » W: Geoff Zahn (12-9) L: Floyd Bannister (12-10) | Second | ½ out |
| Saturday, September 15 |
| » Defeated White Sox (67-80), 11-2 | Anaheim Stadium (33-40) | 74-72 | Won 3 |
| » W: Mike Witt (13-11) L: Tom Seaver (14-10) | Second | ½ out |
| Sunday, September 16 |
| » Defeated White Sox (67-81), 4-2 | Anaheim Stadium (34-40) | 75-72 | Won 4 |
| » W: Ron Romanick (11-12) L: Richard Dotson (13-14) S: Don Aase (8) | Second | ½ out |
| Monday, September 17 |
| » Lost to Royals (77-72), 10-1 | Anaheim Stadium (34-41) | 75-73 | |
| » W: Bud Black (16-11) L: Bruce Kison (4-5) | Third | 1½ out |
| » Major-league debuts: Stu Cliburn (Angels) |
| Tuesday, September 18 |
| » Lost to Royals (78-72), 10-0 | Anaheim Stadium (34-42) | 75-74 | Lost 2 |
| » W: Bret Saberhagen (9-10) L: Jim Slaton (7-8) | Third | 2½ out |
| » Major-league debuts: Dave Smith (Angels) |
| Wednesday, September 19 |
| » Defeated Royals (78-73), 4-3 | Anaheim Stadium (35-42) | 76-74 | |
| » W: Don Aase (4-1) L: Joe Beckwith (8-4) | Second | 1½ out |
| Thursday, September 20 |
| » Defeated Royals (78-74), 2-0 | Anaheim Stadium (36-42) | 77-74 | Won 2 |
| » W: Mike Witt (14-11) L: Mark Gubicza (10-13) | Second | ½ out |
| Friday, September 21 |
| » Defeated Rangers (65-87), 5-4 | Anaheim Stadium (37-42) | 78-74 | Won 3 |
| » W: Curt Kaufman (2-2) L: Ricky Wright (0-2) | Second | ½ out |
| Saturday, September 22 |
| » Lost to Rangers (66-87), 9-7 | Anaheim Stadium (37-43) | 78-75 | |
| » W: Joey McLaughlin (2-1) L: Luis Sanchez (9-7) S: Tom Henke (2) | Third | 1½ out |
| Sunday, September 23 |
| » Lost to Rangers (67-87), 2-1 | Anaheim Stadium (37-44) | 78-76 | Lost 2 |
| » W: Dave Stewart (6-14) L: Jim Slaton (7-9) | Second | 1½ out |
| Monday, September 24 |
| » Lost to Royals (81-75), 4-0 | Royals Stadium (2-1) | 78-77 | Lost 3 |
| » W: Bret Saberhagen (10-10) L: Geoff Zahn (12-10) | Third | 3½ out |
| » Lost to Royals (82-75), 12-4 | |
