| Tuesday, April 5 |
| » Lost to Tigers (1-0), 11-3 | Hubert H. Humphrey Metrodome (0-1) | 0-1 | |
| » W: Jack Morris (1-0) L: Brad Havens (0-1) | Third | 1½ out |
| Wednesday, April 6 |
| » Lost to Tigers (2-0), 9-5 | Hubert H. Humphrey Metrodome (0-2) | 0-2 | Lost 2 |
| » W: Dan Petry (1-0) L: Rick Lysander (0-1) | Fourth | 2½ out |
| Thursday, April 7 |
| » Defeated Tigers (2-1), 5-4 | Hubert H. Humphrey Metrodome (1-2) | 1-2 | |
| » W: Albert Williams (1-0) L: Jerry Ujdur (0-1) S: Ron Davis (1) | Fourth | 2 out |
| Friday, April 8 |
| » Defeated Mariners (2-2), 5-4 | Kingdome (1-0) | 2-2 | Won 2 |
| » W: Rick Lysander (1-1) L: Bill Caudill (0-1) S: Len Whitehouse (1) | Third | 1 out |
| Saturday, April 9 |
| » Lost to Mariners (3-2), 3-2 | Kingdome (1-1) | 2-3 | |
| » W: Roy Thomas (1-0) L: Bryan Oelkers (0-1) S: Bill Caudill (2) | Fourth | 2 out |
| » Major-league debuts: Bryan Oelkers and Tack Wilson (Twins) |
| Sunday, April 10 |
| » Defeated Mariners (3-3), 6-3 | Kingdome (2-1) | 3-3 | |
| » W: Brad Havens (1-1) L: Gaylord Perry (0-1) S: Ron Davis (2) | Third | 2 out |
| Tuesday, April 12 |
| » Lost to Athletics (4-3), 4-3 | Oakland-Alameda County Stadium (0-1) | 3-4 | |
| » W: Dave Beard (2-0) L: Len Whitehouse (0-1) | Fifth | 3 out |
| Wednesday, April 13 |
| » Lost to Athletics (5-3), 5-4 | Oakland-Alameda County Stadium (0-2) | 3-5 | Lost 2 |
| » W: Steve Baker (1-0) L: Albert Williams (1-1) | Sixth | 3 out |
| Friday, April 15 |
| » Lost to Angels (6-4), 8-2 | Hubert H. Humphrey Metrodome (1-3) | 3-6 | Lost 3 |
| » W: Ken Forsch (2-0) L: Frank Viola (0-1) | Sixth | 3 out |
| Saturday, April 16 |
| » Lost to Angels (7-4), 9-5 | Hubert H. Humphrey Metrodome (1-4) | 3-7 | Lost 4 |
| » W: Bruce Kison (2-1) L: Bryan Oelkers (0-2) | Sixth | 3½ out |
| Sunday, April 17 |
| » Defeated Angels (7-5), 11-8 | Hubert H. Humphrey Metrodome (2-4) | 4-7 | |
| » W: Len Whitehouse (1-1) L: Dave Goltz (0-1) S: Ron Davis (3) | Seventh | 3½ out |
| Monday, April 18 |
| » Defeated Mariners (5-9), 8-5 | Hubert H. Humphrey Metrodome (3-4) | 5-7 | Won 2 |
| » W: Jack O'Connor (1-0) L: Mike Moore (0-2) S: Pete Filson (1) | Sixth | 3½ out |
| Tuesday, April 19 |
| » Defeated Mariners (5-10), 6-2 | Hubert H. Humphrey Metrodome (4-4) | 6-7 | Won 3 |
| » W: Len Whitehouse (2-1) L: Edwin Nunez (0-2) | Sixth | 3 out |
| Future Twin Joe Mauer is born in St. Paul, MN. |
| Wednesday, April 20 |
| » Defeated Mariners (5-11), 11-2 | Hubert H. Humphrey Metrodome (5-4) | 7-7 | Won 4 |
| » W: Bobby Castillo (1-0) L: Gaylord Perry (1-2) | Sixth | 2½ out |
| Thursday, April 21 |
| » Lost to Mariners (6-11), 2-0 | Hubert H. Humphrey Metrodome (5-5) | 7-8 | |
| » W: Matt Young (2-2) L: Bryan Oelkers (0-3) S: Bill Caudill (3) | Fifth | 2 out |
| Friday, April 22 |
| » Defeated Yankees (6-8), 5-3 | Yankee Stadium (1-0) | 8-8 | |
| » W: Brad Havens (2-1) L: Doyle Alexander (0-1) S: Len Whitehouse (2) | Fifth | 2½ out |
| Saturday, April 23 |
| » Lost to Yankees (7-8), 7-4 | Yankee Stadium (1-1) | 8-9 | |
| » W: Shane Rawley (3-0) L: Jack O'Connor (1-1) | Fourth | 2 out |
| Monday, April 25 |
| » Lost to Yankees (8-8), 2-1 | Yankee Stadium (1-2) | 8-10 | Lost 2 |
| » W: Ron Guidry (2-1) L: Frank Viola (0-2) | Fifth | 2½ out |
| Tuesday, April 26 |
| » Lost to Indians (8-9), 7-1 | Cleveland Stadium (0-1) | 8-11 | Lost 3 |
| » W: Lary Sorensen (1-3) L: Bobby Castillo (1-1) | Fifth | 3½ out |
| Wednesday, April 27 |
| » Defeated Indians (8-10), 5-3 | Cleveland Stadium (1-1) | 9-11 | |
| » W: Albert Williams (2-1) L: Ed Glynn (0-1) S: Rick Lysander (1) | Fourth | 3½ out |
| Friday, April 29 |
| » Defeated Brewers (10-8), 7-4 | Hubert H. Humphrey Metrodome (6-5) | 10-11 | Won 2 |
| » W: Brad Havens (3-1) L: Bob McClure (0-4) S: Albert Williams (1) | Fourth | 2½ out |
| Saturday, April 30 |
| » Defeated Brewers (10-9), 9-7 | Hubert H. Humphrey Metrodome (7-5) | 11-11 | Won 3 |
| » W: Ron Davis (1-0) L: Pete Ladd (0-2) | Fifth | 2½ out |
| Sunday, May 1 |
| » Lost to Brewers (11-9), 8-4 | Hubert H. Humphrey Metrodome (7-6) | 11-12 | |
| » W: Don Sutton (4-1) L: Albert Williams (2-2) | Fourth | 2½ out |
| Tuesday, May 3 |
| » Lost to Indians (11-11), 3-1 | Hubert H. Humphrey Metrodome (7-7) | 11-13 | Lost 2 |
| » W: Bert Blyleven (2-3) L: Bobby Castillo (1-2) S: Neal Heaton (2) | Fourth | 3 out |
| Wednesday, May 4 |
| » Lost to Indians (12-11), 11-7 | Hubert H. Humphrey Metrodome (7-8) | 11-14 | Lost 3 |
| » W: Dan Spillner (1-2) L: Ron Davis (1-1) | Sixth | 3½ out |
| Thursday, May 5 |
| » Lost to Indians (13-11), 7-5 | Hubert H. Humphrey Metrodome (7-9) | 11-15 | Lost 4 |
| » W: Rick Sutcliffe (4-1) L: Brad Havens (3-2) S: Neal Heaton (3) | Sixth | 4 out |
| Friday, May 6 |
| » Lost to Yankees (12-13), 8-4 | Hubert H. Humphrey Metrodome (7-10) | 11-16 | Lost 5 |
| » W: Ron Guidry (3-2) L: Jack O'Connor (1-2) S: Rich Gossage (1) | Sixth | 5 out |
| Saturday, May 7 |
| » Lost to Yankees (13-13), 8-7 | Hubert H. Humphrey Metrodome (7-11) | 11-17 | Lost 6 |
| » W: George Frazier (1-1) L: Albert Williams (2-3) S: Rich Gossage (2) | Sixth | 6 out |
| Sunday, May 8 |
| » Defeated Yankees (13-14), 6-5 | Hubert H. Humphrey Metrodome (8-11) | 12-17 | |
| » W: Len Whitehouse (3-1) L: Dale Murray (0-1) | Fifth | 5 out |
| Tuesday, May 10 |
| » Lost to Brewers (14-12), 4-1 | County Stadium (0-1) | 12-18 | |
| » W: Moose Haas (1-0) L: Brad Havens (3-3) S: Tom Tellmann (1) | Sixth | 5½ out |
| Wednesday, May 11 |
| » Lost to Brewers (15-12), 4-1 | County Stadium (0-2) | 12-19 | Lost 2 |
| » W: Bob McClure (1-5) L: Albert Williams (2-4) | Sixth | 6½ out |
| Friday, May 13 |
| » Defeated Angels (18-13), 5-4 | Anaheim Stadium (1-0) | 13-19 | |
| » W: Len Whitehouse (4-1) L: Mike Witt (1-4) S: Ron Davis (4) | Sixth | 5½ out |
| Saturday, May 14 |
| » Defeated Angels (18-14), 2-1 | Anaheim Stadium (2-0) | 14-19 | Won 2 |
| » W: Ken Schrom (1-0) L: Ken Forsch (3-2) S: Ron Davis (5) | Fifth | 4½ out |
| Sunday, May 15 |
| » Defeated Angels (18-15), 8-6 | Anaheim Stadium (3-0) | 15-19 | Won 3 |
| » W: Pete Filson (1-0) L: Dave Goltz (0-2) S: Ron Davis (6) | Fifth | 3½ out |
| Monday, May 16 |
| » Lost to Athletics (18-16), 7-6 | Hubert H. Humphrey Metrodome (8-12) | 15-20 | |
| » W: Mike Norris (4-3) L: Brad Havens (3-4) S: Tom Burgmeier (3) | Fifth | 4 out |
| Tuesday, May 17 |
| » Lost to Athletics (19-16), 7-6 | Hubert H. Humphrey Metrodome (8-13) | 15-21 | Lost 2 |
| » W: Chris Codiroli (4-2) L: Albert Williams (2-5) S: Steve McCatty (4) | Fourth | 5 out |
| Wednesday, May 18 |
| » Defeated Athletics (19-17), 16-5 | Hubert H. Humphrey Metrodome (9-13) | 16-21 | |
| » W: Frank Viola (1-2) L: Bill Krueger (4-4) | Fifth | 5 out |
| Thursday, May 19 |
| » Lost to Red Sox (20-14), 4-1 | Fenway Park (0-1) | 16-22 | |
| » W: Doug Bird (1-1) L: Bobby Castillo (1-3) S: Luis Aponte (2) | Fourth | 5 out |
| Friday, May 20 |
| » Defeated Red Sox (20-15), 10-4 | Fenway Park (1-1) | 17-22 | |
| » W: Ken Schrom (2-0) L: Bruce Hurst (3-2) S: Rick Lysander (2) | Fourth | 5 out |
| Saturday, May 21 |
| » Lost to Red Sox (21-15), 11-4 | Fenway Park (1-2) | 17-23 | |
| » W: Bob Ojeda (2-1) L: Brad Havens (3-5) | Fourth | 5 out |
| Sunday, May 22 |
| » Defeated Red Sox (21-16), 4-3 | Fenway Park (2-2) | 18-23 | |
| » W: Ron Davis (2-1) L: Luis Aponte (3-2) | Fourth | 4 out |
| Monday, May 23 |
| » Defeated Orioles (23-17), 12-4 | Memorial Stadium (1-0) | 19-23 | Won 2 |
| » W: Frank Viola (2-2) L: Storm Davis (2-1) | Fourth | 4 out |
| Tuesday, May 24 |
| » Defeated Orioles (23-18), 6-1 | Memorial Stadium (2-0) | 20-23 | Won 3 |
| » W: Bobby Castillo (2-3) L: Scott McGregor (4-3) | Fifth | 4 out |
| Wednesday, May 25 |
| » Defeated Orioles (23-19), 7-4 | Memorial Stadium (3-0) | 21-23 | Won 4 |
| » W: Ken Schrom (3-0) L: Dennis Martinez (3-8) S: Ron Davis (7) | Fifth | 4 out |
| Friday, May 27 |
| » Lost to Tigers (19-22), 7-4 | Tiger Stadium (0-1) | 21-24 | |
| » W: Larry Pashnick (1-0) L: Rick Lysander (1-2) S: Aurelio Lopez (6) | Fourth | 5½ out |
| » Lost to Tigers (20-22), 2-1 | Tiger Stadium (0-2) | 21-25 | Lost 2 |
| » W: Howard Bailey (2-2) L: Rick Lysander (1-3) | Fourth | 5½ out |
| Saturday, May 28 |
| » Lost to Tigers (21-22), 6-1 | Tiger Stadium (0-3) | 21-26 | Lost 3 |
| » W: Milt Wilcox (5-5) L: Albert Williams (2-6) | Fourth | 6½ out |
| Sunday, May 29 |
| » Lost to Tigers (22-22), 7-6 | Tiger Stadium (0-4) | 21-27 | Lost 4 |
| » W: Aurelio Lopez (3-2) L: Rick Lysander (1-4) | Fifth | 7½ out |
| Monday, May 30 |
| » Lost to Orioles (26-21), 6-1 | Hubert H. Humphrey Metrodome (9-14) | 21-28 | Lost 5 |
| » W: Mike Boddicker (2-2) L: Bobby Castillo (2-4) | Sixth | 7½ out |
| Tuesday, May 31 |
| » Defeated Orioles (26-22), 10-3 | Hubert H. Humphrey Metrodome (10-14) | 22-28 | |
| » W: Ken Schrom (4-0) L: Storm Davis (3-2) | Sixth | 6½ out |
| Wednesday, June 1 |
| » Lost to Orioles (27-22), 6-3 | Hubert H. Humphrey Metrodome (10-15) | 22-29 | |
| » W: Scott McGregor (6-3) L: Rick Lysander (1-5) S: Tippy Martinez (6) | Sixth | 6½ out |
| Friday, June 3 |
| » Lost to Red Sox (27-21), 6-3 | Hubert H. Humphrey Metrodome (10-16) | 22-30 | Lost 2 |
| » W: Oil Can Boyd (1-0) L: Albert Williams (2-7) S: Bob Stanley (11) | Fifth | 8 out |
| Saturday, June 4 |
| » Lost to Red Sox (28-21), 8-6 | Hubert H. Humphrey Metrodome (10-17) | 22-31 | Lost 3 |
| » W: Dennis Eckersley (4-2) L: Frank Viola (2-3) S: Luis Aponte (3) | Sixth | 9 out |
| Sunday, June 5 |
| » Defeated Red Sox (28-22), 10-4 | Hubert H. Humphrey Metrodome (11-17) | 23-31 | |
| » W: Brad Havens (4-5) L: Bruce Hurst (4-4) | Sixth | 8 out |
| » Major-league debuts: Greg Gagne (Twins) |
| Tuesday, June 7 |
| » Lost to Royals (24-24), 9-4 | Royals Stadium (0-1) | 23-32 | |
| » W: Larry Gura (5-7) L: Ken Schrom (4-1) S: Dan Quisenberry (13) | Sixth | 7½ out |
| Wednesday, June 8 |
| » Lost to Royals (25-24), 9-2 | Royals Stadium (0-2) | 23-33 | Lost 2 |
| » W: Steve Renko (5-4) L: Pete Filson (1-1) S: Dan Quisenberry (14) | Sixth | 8½ out |
| Thursday, June 9 |
| » Lost to Royals (26-24), 6-5 | Royals Stadium (0-3) | 23-34 | Lost 3 |
| » W: Bill Castro (1-0) L: Rick Lysander (1-6) S: Dan Quisenberry (15) | Seventh | 9½ out |
| Friday, June 10 |
| » Lost to Rangers (27-27), 4-2 | Hubert H. Humphrey Metrodome (11-18) | 23-35 | Lost 4 |
| » W: Frank Tanana (2-1) L: Frank Viola (2-4) S: John Butcher (2) | Seventh | 10½ out |
| Saturday, June 11 |
| » Lost to Rangers (28-27), 11-0 | Hubert H. Humphrey Metrodome (11-19) | 23-36 | Lost 5 |
| » W: Danny Darwin (4-5) L: Brad Havens (4-6) | Seventh | 10½ out |
| Sunday, June 12 |
| » Lost to Rangers (29-27), 4-3 | Hubert H. Humphrey Metrodome (11-20) | 23-37 | Lost 6 |
| » W: Odell Jones (2-2) L: Ron Davis (2-2) | Seventh | 10½ out |
| Monday, June 13 |
| » Defeated Royals (28-26), 9-4 | Hubert H. Humphrey Metrodome (12-20) | 24-37 | |
| » W: Bobby Castillo (3-4) L: Steve Renko (5-5) | Seventh | 10½ out |
| » Major-league debuts: Houston Jimenez (Twins) |
| Tuesday, June 14 |
| » Defeated Royals (28-27), 8-1 | Hubert H. Humphrey Metrodome (13-20) | 25-37 | Won 2 |
| » W: Albert Williams (3-7) L: Keith Creel (0-2) | Sixth | 10 out |
| Wednesday, June 15 |
| » Defeated Royals (28-28), 6-2 | Hubert H. Humphrey Metrodome (14-20) | 26-37 | Won 3 |
| » W: Frank Viola (3-4) L: Paul Splittorff (4-2) | Sixth | 9 out |
| Thursday, June 16 |
| » Defeated Rangers (31-29), 4-3 | Arlington Stadium (1-0) | 27-37 | Won 4 |
| » W: Rick Lysander (2-6) L: Danny Darwin (4-6) S: Ron Davis (8) | Sixth | 8½ out |
| Friday, June 17 |
| » Lost to Rangers (32-29), 10-1 | Arlington Stadium (1-1) | 27-38 | |
| » W: Rick Honeycutt (9-3) L: Ken Schrom (4-2) | Sixth | 8½ out |
| Saturday, June 18 |
| » Defeated Rangers (32-30), 8-4 | Arlington Stadium (2-1) | 28-38 | |
| » W: Bobby Castillo (4-4) L: Mike Smithson (5-5) S: Ron Davis (9) | Sixth | 8½ out |
| Sunday, June 19 |
| » Lost to Rangers (33-30), 4-1 | Arlington Stadium (2-2) | 28-39 | |
| » W: Charlie Hough (5-6) L: Albert Williams (3-8) | Sixth | 8½ out |
| Monday, June 20 |
| » Lost to Blue Jays (36-28), 2-1 | Exhibition Stadium (0-1) | 28-40 | Lost 2 |
| » W: Jim Gott (5-5) L: Ron Davis (2-3) | Sixth | 9½ out |
| Tuesday, June 21 |
| » Lost to Blue Jays (37-28), 8-3 | Exhibition Stadium (0-2) | 28-41 | Lost 3 |
| » W: Jim Acker (1-0) L: Bryan Oelkers (0-4) | Sixth | 9½ out |
| Wednesday, June 22 |
| » Defeated Blue Jays (37-29), 4-3 | Exhibition Stadium (1-2) | 29-41 | |
| » W: Ken Schrom (5-2) L: Dave Stieb (10-5) S: Ron Davis (10) | Sixth | 8½ out |
| Thursday, June 23 |
| » Lost to White Sox (34-33), 8-6 | Comiskey Park I (0-1) | 29-42 | |
| » W: Floyd Bannister (3-8) L: Bobby Castillo (4-5) S: Dennis Lamp (1) | Sixth | 9½ out |
| Friday, June 24 |
| » Defeated White Sox (34-34), 5-1 | Comiskey Park I (1-1) | 30-42 | |
| » W: Albert Williams (4-8) L: Britt Burns (3-5) S: Rick Lysander (3) | Sixth | 9 out |
| Saturday, June 25 |
| » Lost to White Sox (35-34), 8-3 | Comiskey Park I (1-2) | 30-43 | |
| » W: La Marr Hoyt (9-7) L: Frank Viola (3-5) S: Juan Agosto (4) | Sixth | 10 out |
| Sunday, June 26 |
| » Lost to White Sox (36-34), 9-7 | Comiskey Park I (1-3) | 30-44 | Lost 2 |
| » W: Richard Dotson (7-5) L: Bryan Oelkers (0-5) S: Salome Barojas (6) | Sixth | 11 out |
| Tuesday, June 28 |
| » Defeated Blue Jays (40-31), 5-2 | Hubert H. Humphrey Metrodome (15-20) | 31-44 | |
| » W: Ken Schrom (6-2) L: Dave Stieb (10-6) S: Ron Davis (11) | Sixth | 10½ out |
| Wednesday, June 29 |
| » Lost to Blue Jays (41-31), 4-2 | Hubert H. Humphrey Metrodome (15-21) | 31-45 | |
| » W: Jim Clancy (7-5) L: Bobby Castillo (4-6) | Fifth | 10½ out |
| Thursday, June 30 |
| » Lost to Blue Jays (42-31), 11-3 | Hubert H. Humphrey Metrodome (15-22) | 31-46 | Lost 2 |
| » W: Luis Leal (8-6) L: Albert Williams (4-9) | Sixth | 11½ out |
| Friday, July 1 |
| » Defeated White Sox (38-36), 6-3 | Hubert H. Humphrey Metrodome (16-22) | 32-46 | |
| » W: Frank Viola (4-5) L: La Marr Hoyt (9-8) S: Ron Davis (12) | Sixth | 11½ out |
| Saturday, July 2 |
| » Lost to White Sox (39-36), 4-2 | Hubert H. Humphrey Metrodome (16-23) | 32-47 | |
| » W: Richard Dotson (8-5) L: Ken Schrom (6-3) S: Salome Barojas (8) | Sixth | 12½ out |
| Sunday, July 3 |
| » Defeated White Sox (39-37), 4-3 | Hubert H. Humphrey Metrodome (17-23) | 33-47 | |
| » W: Ron Davis (3-3) L: Salome Barojas (1-1) | Sixth | 12½ out |
| Monday, July 4 |
| » Lost to White Sox (40-37), 12-6 | Hubert H. Humphrey Metrodome (17-24) | 33-48 | |
| » W: Dennis Lamp (5-5) L: Rick Lysander (2-7) | Sixth | 12½ out |
| Friday, July 8 |
| » Lost to Indians (35-44), 10-4 | Hubert H. Humphrey Metrodome (17-25) | 33-49 | Lost 2 |
| » W: Bert Blyleven (6-8) L: Frank Viola (4-6) | Sixth | 12½ out |
| » Major-league debuts: Mike Walters (Twins) |
| Saturday, July 9 |
| » Defeated Indians (35-45), 3-2 | Hubert H. Humphrey Metrodome (18-25) | 34-49 | |
| » W: Ken Schrom (7-3) L: Rick Sutcliffe (10-4) S: Ron Davis (13) | Sixth | 11½ out |
| Sunday, July 10 |
| » Defeated Indians (35-46), 6-4 | Hubert H. Humphrey Metrodome (19-25) | 35-49 | Won 2 |
| » W: Albert Williams (5-9) L: Juan Eichelberger (3-8) S: Ron Davis (14) | Fifth | 10½ out |
| Monday, July 11 |
| » Defeated Yankees (43-37), 4-2 | Hubert H. Humphrey Metrodome (20-25) | 36-49 | Won 3 |
| » W: Bobby Castillo (5-6) L: Jay Howell (1-4) | Sixth | 10½ out |
| Tuesday, July 12 |
| » Lost to Yankees (44-37), 4-3 | Hubert H. Humphrey Metrodome (20-26) | 36-50 | |
| » W: George Frazier (3-1) L: Rick Lysander (2-8) | Sixth | 10½ out |
| Wednesday, July 13 |
| » Defeated Yankees (44-38), 6-1 | Hubert H. Humphrey Metrodome (21-26) | 37-50 | |
| » W: Ken Schrom (8-3) L: Ron Guidry (10-5) S: Ron Davis (15) | Sixth | 9½ out |
| Thursday, July 14 |
| » Lost to Brewers (43-39), 5-1 | County Stadium (0-3) | 37-51 | |
| » W: Don Sutton (7-5) L: Albert Williams (5-10) | Sixth | 10½ out |
| Friday, July 15 |
| » Lost to Brewers (44-39), 6-3 | County Stadium (0-4) | 37-52 | Lost 2 |
| » W: Mike Caldwell (7-7) L: Bobby Castillo (5-7) | Sixth | 10½ out |
| Saturday, July 16 |
| » Lost to Brewers (45-39), 5-0 | County Stadium (0-5) | 37-53 | Lost 3 |
| » W: Moose Haas (7-2) L: Frank Viola (4-7) | Sixth | 10½ out |
| Sunday, July 17 |
| » Lost to Brewers (46-39), 10-6 | County Stadium (0-6) | 37-54 | Lost 4 |
| » W: Chuck Porter (2-4) L: Ken Schrom (8-4) S: Jim Slaton (3) | Sixth | 10½ out |
| Monday, July 18 |
| » Lost to Yankees (48-39), 4-2 | Yankee Stadium (1-3) | 37-55 | Lost 5 |
| » W: Ron Guidry (11-5) L: Albert Williams (5-11) | Sixth | 11 out |
| Tuesday, July 19 |
| » Lost to Yankees (49-39), 4-0 | Yankee Stadium (1-4) | 37-56 | Lost 6 |
| » W: Shane Rawley (9-8) L: Bobby Castillo (5-8) | Sixth | 11 out |
| Wednesday, July 20 |
| » Lost to Yankees (50-39), 6-4 | Yankee Stadium (1-5) | 37-57 | Lost 7 |
| » W: Rich Gossage (6-3) L: Ron Davis (3-4) | Sixth | 12 out |
| Friday, July 22 |
| » Lost to Indians (39-53), 8-5 | Cleveland Stadium (1-2) | 37-58 | Lost 8 |
| » W: Jamie Easterly (1-1) L: Rick Lysander (2-9) S: Dan Spillner (8) | Sixth | 12½ out |
| Saturday, July 23 |
| » Defeated Indians (39-54), 5-2 | Cleveland Stadium (2-2) | 38-58 | |
| » W: Albert Williams (6-11) L: Len Barker (7-10) S: Ron Davis (16) | Sixth | 11½ out |
| Sunday, July 24 |
| » Defeated Indians (39-55), 7-5 | Cleveland Stadium (3-2) | 39-58 | Won 2 |
| » W: Bobby Castillo (6-8) L: Rick Sutcliffe (12-5) S: Ron Davis (17) | Sixth | 10 out |
| » Defeated Indians (39-56), 5-4 | Cleveland Stadium (4-2) | 40-58 | Won 3 |
| » W: Brad Havens (5-6) L: Tom Brennan (0-1) S: Ron Davis (18) | Sixth | 10 out |
| Monday, July 25 |
| » Defeated Brewers (52-42), 17-3 | Hubert H. Humphrey Metrodome (22-26) | 41-58 | Won 4 |
| » W: Frank Viola (5-7) L: Mike Caldwell (7-8) | Sixth | 10 out |
| Tuesday, July 26 |
| » Defeated Brewers (52-43), 6-5 | Hubert H. Humphrey Metrodome (23-26) | 42-58 | Won 5 |
| » W: Len Whitehouse (5-1) L: Tom Tellmann (7-3) | Sixth | 9½ out |
| Wednesday, July 27 |
| » Lost to Brewers (53-43), 13-9 | Hubert H. Humphrey Metrodome (23-27) | 42-59 | |
| » W: Jim Slaton (9-3) L: Brad Havens (5-7) | Sixth | 10½ out |
| Friday, July 29 |
| » Defeated Mariners (38-64), 4-3 | Hubert H. Humphrey Metrodome (24-27) | 43-59 | |
| » W: Bobby Castillo (7-8) L: Bill Caudill (2-7) S: Ron Davis (19) | Sixth | 10½ out |
| Saturday, July 30 |
| » Lost to Mariners (39-64), 7-3 | Hubert H. Humphrey Metrodome (24-28) | 43-60 | |
| » W: Glenn Abbott (4-3) L: Frank Viola (5-8) S: Mike Stanton (3) | Sixth | 11½ out |
| Sunday, July 31 |
| » Lost to Mariners (40-64), 3-2 | Hubert H. Humphrey Metrodome (24-29) | 43-61 | Lost 2 |
| » W: Roy Thomas (2-0) L: Ron Davis (3-5) S: Bill Caudill (19) | Sixth | 11½ out |
| Monday, August 1 |
| » Lost to Angels (50-54), 12-6 | Hubert H. Humphrey Metrodome (24-30) | 43-62 | Lost 3 |
| » W: Mike Witt (5-8) L: Brad Havens (5-8) | Sixth | 12 out |
| » Defeated Angels (50-55), 7-0 | Hubert H. Humphrey Metrodome (25-30) | 44-62 | |
| » W: Rick Lysander (3-9) L: Steve Brown (0-1) | Sixth | 12 out |
| Tuesday, August 2 |
| » Lost to Angels (51-55), 2-1 | Hubert H. Humphrey Metrodome (25-31) | 44-63 | |
| » W: Bruce Kison (9-5) L: Bobby Castillo (7-9) | Sixth | 13 out |
| Wednesday, August 3 |
| » Lost to Angels (52-55), 7-5 | Hubert H. Humphrey Metrodome (25-32) | 44-64 | Lost 2 |
| » W: Bruce Kison (10-5) L: Mike Walters (0-1) | Sixth | 13 out |
| Thursday, August 4 |
| » Defeated Athletics (50-59), 4-3 | Hubert H. Humphrey Metrodome (26-32) | 45-64 | |
| » W: Len Whitehouse (6-1) L: Tom Burgmeier (6-7) | Sixth | 13 out |
| Friday, August 5 |
| » Lost to Athletics (51-59), 3-2 | Hubert H. Humphrey Metrodome (26-33) | 45-65 | |
| » W: Gorman Heimueller (1-2) L: Jack O'Connor (1-3) S: Dave Beard (6) | Sixth | 13 out |
| Saturday, August 6 |
| » Lost to Athletics (52-59), 6-4 | Hubert H. Humphrey Metrodome (26-34) | 45-66 | Lost 2 |
| » W: Keith Atherton (2-0) L: Ron Davis (3-6) | Sixth | 14 out |
| Sunday, August 7 |
| » Lost to Athletics (53-59), 6-0 | Hubert H. Humphrey Metrodome (26-35) | 45-67 | Lost 3 |
| » W: Chris Codiroli (8-8) L: Frank Viola (5-9) S: Keith Atherton (2) | Sixth | 15 out |
| Monday, August 8 |
| » Defeated Angels (53-59), 4-2 | Anaheim Stadium (4-0) | 46-67 | |
| » W: Ken Schrom (9-4) L: Tommy John (8-9) | Sixth | 14½ out |
| Tuesday, August 9 |
| » Lost to Angels (54-59), 8-2 | Anaheim Stadium (4-1) | 46-68 | |
| » W: Rick Steirer (1-0) L: Rick Lysander (3-10) S: Bruce Kison (2) | Sixth | 15½ out |
| Wednesday, August 10 |
| » Defeated Angels (54-60), 4-1 | Anaheim Stadium (5-1) | 47-68 | |
| » W: Bobby Castillo (8-9) L: Geoff Zahn (8-7) | Sixth | 15 out |
| Thursday, August 11 |
| » Lost to Athletics (56-60), 6-0 | Oakland-Alameda County Stadium (0-3) | 47-69 | |
| » W: Chris Codiroli (9-8) L: Frank Viola (5-10) | Sixth | 16 out |
| Friday, August 12 |
| » Defeated Athletics (56-61), 5-3 | Oakland-Alameda County Stadium (1-3) | 48-69 | |
| » W: Ken Schrom (10-4) L: Tom Underwood (8-6) S: Ron Davis (20) | Sixth | 16 out |
| » Major-league debuts: Mark Smith (Athletics) |
| Saturday, August 13 |
| » Defeated Athletics (56-62), 7-3 | Oakland-Alameda County Stadium (2-3) | 49-69 | Won 2 |
| » W: Albert Williams (7-11) L: Tim Conroy (5-5) | Sixth | 15 out |
| Sunday, August 14 |
| » Lost to Athletics (57-62), 6-0 | Oakland-Alameda County Stadium (2-4) | 49-70 | |
| » W: Steve McCatty (4-5) L: Bobby Castillo (8-10) | Sixth | 15 out |
| Monday, August 15 |
| » Defeated Mariners (46-72), 7-4 | Kingdome (3-1) | 50-70 | |
| » W: Frank Viola (6-10) L: Bryan Clark (5-5) S: Ron Davis (21) | Sixth | 15 out |
| Tuesday, August 16 |
| » Defeated Mariners (46-73), 5-1 | Kingdome (4-1) | 51-70 | Won 2 |
| » W: Ken Schrom (11-4) L: Matt Young (9-12) S: Ron Davis (22) | Sixth | 15 out |
| Wednesday, August 17 |
| » Defeated Mariners (46-74), 7-4 | Kingdome (5-1) | 52-70 | Won 3 |
| » W: Albert Williams (8-11) L: Mike Moore (3-4) S: Mike Walters (1) | Sixth | 15 out |
| Friday, August 19 |
| » Lost to Tigers (67-52), 5-1 | Hubert H. Humphrey Metrodome (26-36) | 52-71 | |
| » W: Jack Morris (15-8) L: Bobby Castillo (8-11) | Sixth | 16½ out |
| Saturday, August 20 |
| » Lost to Tigers (68-52), 9-1 | Hubert H. Humphrey Metrodome (26-37) | 52-72 | Lost 2 |
| » W: Juan Berenguer (6-4) L: Frank Viola (6-11) | Sixth | 16½ out |
| Sunday, August 21 |
| » Defeated Tigers (68-53), 4-3 | Hubert H. Humphrey Metrodome (27-37) | 53-72 | |
| » W: Ken Schrom (12-4) L: Larry Pashnick (1-3) S: Ron Davis (23) | Sixth | 16½ out |
| Tuesday, August 23 |
| » Defeated Red Sox (60-64), 3-2 | Hubert H. Humphrey Metrodome (28-37) | 54-72 | Won 2 |
| » W: Albert Williams (9-11) L: Oil Can Boyd (3-3) S: Ron Davis (24) | Sixth | 16 out |
| Wednesday, August 24 |
| » Defeated Red Sox (60-65), 8-7 | Hubert H. Humphrey Metrodome (29-37) | 55-72 | Won 3 |
| » W: Len Whitehouse (7-1) L: Bob Stanley (8-9) S: Ron Davis (25) | Sixth | 16 out |
| Thursday, August 25 |
| » Defeated Red Sox (60-66), 5-2 | Hubert H. Humphrey Metrodome (30-37) | 56-72 | Won 4 |
| » W: Frank Viola (7-11) L: Dennis Eckersley (7-10) | Fifth | 15 out |
| Friday, August 26 |
| » Lost to Orioles (72-52), 9-0 | Memorial Stadium (3-1) | 56-73 | |
| » W: Mike Boddicker (11-6) L: Ken Schrom (12-5) | Fifth | 15 out |
| Saturday, August 27 |
| » Lost to Orioles (73-52), 5-3 | Memorial Stadium (3-2) | 56-74 | Lost 2 |
| » W: Jim Palmer (3-3) L: Albert Williams (9-12) S: Tim Stoddard (8) | Sixth | 16 out |
| Sunday, August 28 |
| » Lost to Orioles (74-52), 11-4 | Memorial Stadium (3-3) | 56-75 | Lost 3 |
| » W: Mike Flanagan (8-3) L: Bobby Castillo (8-12) S: Sammy Stewart (5) | Fifth | 17 out |
| Monday, August 29 |
| » Defeated Tigers (73-56), 5-4 | Tiger Stadium (1-4) | 57-75 | |
| » W: Rick Lysander (4-10) L: Aurelio Lopez (8-7) S: Ron Davis (26) | Fifth | 17 out |
| Tuesday, August 30 |
| » Lost to Tigers (74-56), 4-3 | Tiger Stadium (1-5) | 57-76 | |
| » W: Dan Petry (14-8) L: Ken Schrom (12-6) | Sixth | 18 out |
| Thursday, September 1 |
| » Defeated Red Sox (63-70), 11-0 | Fenway Park (3-2) | 58-76 | |
| » W: Albert Williams (10-12) L: Dennis Eckersley (7-11) | Sixth | 19 out |
| » Lost to Red Sox (64-70), 9-3 | Fenway Park (3-3) | 58-77 | |
| » W: Bob Ojeda (7-7) L: Rick Lysander (4-11) | Sixth | 19 out |
| Friday, September 2 |
| » Lost to Orioles (78-53), 1-0 | Hubert H. Humphrey Metrodome (30-38) | 58-78 | Lost 2 |
| » W: Mike Flanagan (9-3) L: Frank Viola (7-12) S: Tim Stoddard (9) | Sixth | 19 out |
| Saturday, September 3 |
| » Lost to Orioles (79-53), 13-0 | Hubert H. Humphrey Metrodome (30-39) | 58-79 | Lost 3 |
| » W: Scott McGregor (17-5) L: Ken Schrom (12-7) | Sixth | 20 out |
| » Major-league debuts: Tim Teufel (Twins) |
| Sunday, September 4 |
| » Lost to Orioles (80-53), 9-6 | Hubert H. Humphrey Metrodome (30-40) | 58-80 | Lost 4 |
| » W: Storm Davis (12-5) L: Ron Davis (3-7) S: Tippy Martinez (14) | Sixth | 20 out |
| Monday, September 5 |
| » Lost to Rangers (65-74), 7-3 | Arlington Stadium (2-3) | 58-81 | Lost 5 |
| » W: John Butcher (6-5) L: Rick Lysander (4-12) | Sixth | 21 out |
| Tuesday, September 6 |
| » Defeated Rangers (65-75), 5-3 | Arlington Stadium (3-3) | 59-81 | |
| » W: Ron Davis (4-7) L: Frank Tanana (7-7) S: Mike Walters (2) | Sixth | 21 out |
| Wednesday, September 7 |
| » Lost to Rangers (66-75), 3-0 | Arlington Stadium (3-4) | 59-82 | |
| » W: Charlie Hough (13-12) L: Albert Williams (10-13) | Sixth | 22 out |
| Friday, September 9 |
| » Defeated Royals (66-74), 7-6 | Hubert H. Humphrey Metrodome (31-40) | 60-82 | |
| » W: Jack O'Connor (2-3) L: Mike Armstrong (7-7) | Sixth | 22½ out |
| Saturday, September 10 |
| » Defeated Royals (66-75), 6-3 | Hubert H. Humphrey Metrodome (32-40) | 61-82 | Won 2 |
| » W: Pete Filson (2-1) L: Eric Rasmussen (2-5) S: Ron Davis (27) | Sixth | 22½ out |
| Sunday, September 11 |
| » Lost to Royals (67-75), 3-1 | Hubert H. Humphrey Metrodome (32-41) | 61-83 | |
| » W: Danny Jackson (1-0) L: Jay Pettibone (0-1) S: Dan Quisenberry (38) | Sixth | 23½ out |
| » Major-league debuts: Danny Jackson (Royals) |
| Tuesday, September 13 |
| » Lost to White Sox (85-59), 5-1 | Hubert H. Humphrey Metrodome (32-42) | 61-84 | Lost 2 |
| » W: Richard Dotson (18-7) L: Frank Viola (7-13) | Sixth | 24½ out |
| Wednesday, September 14 |
| » Defeated White Sox (85-60), 1-0 | Hubert H. Humphrey Metrodome (33-42) | 62-84 | |
| » W: Ron Davis (5-7) L: Britt Burns (9-10) | Sixth | 23½ out |
| Thursday, September 15 |
| » Defeated Blue Jays (81-67), 6-2 | Hubert H. Humphrey Metrodome (34-42) | 63-84 | Won 2 |
| » W: Ken Schrom (13-7) L: Dave Stieb (15-12) | Sixth | 23½ out |
| Friday, September 16 |
| » Defeated Blue Jays (81-68), 11-4 | Hubert H. Humphrey Metrodome (35-42) | 64-84 | Won 3 |
| » W: Rick Lysander (5-12) L: Jim Gott (9-14) | Sixth | 23½ out |
| Saturday, September 17 |
| » Lost to Blue Jays (82-68), 13-3 | Hubert H. Humphrey Metrodome (35-43) | 64-85 | |
| » W: Luis Leal (13-10) L: Jay Pettibone (0-2) | Sixth | 24½ out |
| Monday, September 19 |
| » Defeated White Sox (89-61), 7-5 | Comiskey Park I (2-3) | 65-85 | |
| » W: Mike Walters (1-1) L: Salome Barojas (3-3) S: Ron Davis (28) | Fifth | 24 out |
| Wednesday, September 21 |
| » Lost to White Sox (90-61), 2-1 | Comiskey Park I (2-4) | 65-86 | |
| » W: La Marr Hoyt (22-10) L: Ken Schrom (13-8) | Sixth | 26 out |
| » Lost to White Sox (91-61), 7-6 | Comiskey Park I (2-5) | 65-87 | Lost 2 |
| » W: Guy Hoffman (1-0) L: Ron Davis (5-8) | Sixth | 26 out |
| Thursday, September 22 |
| » Defeated Royals (73-79), 2-1 | Royals Stadium (1-3) | 66-87 | |
|