| Monday, April 4 |
| » Defeated Braves (0-1), 5-4 | Riverfront Stadium (1-0) | 1-0 | |
| » W: Mario Soto (1-0) L: Steve Bedrosian (0-1) S: Tom Hume (1) | First | -- |
| » Major-league debuts: Jeff Jones (Reds) |
| Wednesday, April 6 |
| » Lost to Braves (1-1), 5-1 | Riverfront Stadium (1-1) | 1-1 | |
| » W: Pascual Perez (1-0) L: Bruce Berenyi (0-1) | Second | 1 out |
| Friday, April 8 |
| » Defeated Cubs (0-3), 7-3 | Riverfront Stadium (2-1) | 2-1 | |
| » W: Mario Soto (2-0) L: Steve Trout (0-1) | First | -- |
| Saturday, April 9 |
| » Defeated Cubs (0-4), 8-4 | Riverfront Stadium (3-1) | 3-1 | Won 2 |
| » W: Frank Pastore (1-0) L: Chuck Rainey (0-1) | First | -- |
| » Major-league debuts: Tom Foley (Reds) Steve Lake (Cubs) |
| Former Red Bill Kennedy dies in Seattle, WA at the age of 63. |
| Sunday, April 10 |
| » Defeated Cubs (0-5), 7-2 | Riverfront Stadium (4-1) | 4-1 | Won 3 |
| » W: Bruce Berenyi (1-1) L: Fergie Jenkins (0-2) | First | -- |
| Monday, April 11 |
| » Defeated Cubs (0-6), 5-1 | Riverfront Stadium (5-1) | 5-1 | Won 4 |
| » W: Joe Price (1-0) L: Dickie Noles (0-2) | First | -- |
| » Major-league debuts: Dann Bilardello (Reds) |
| Tuesday, April 12 |
| » Lost to Braves (6-1), 4-1 | Atlanta-Fulton County Stadium (0-1) | 5-2 | |
| » W: Rick Behenna (1-0) L: Mario Soto (2-1) S: Terry Forster (1) | Second | 1 out |
| » Major-league debuts: Rick Behenna (Braves) |
| Wednesday, April 13 |
| » Lost to Braves (7-1), 6-1 | Atlanta-Fulton County Stadium (0-2) | 5-3 | Lost 2 |
| » W: Rick Camp (1-0) L: Frank Pastore (1-1) | Third | 2 out |
| Friday, April 15 |
| » Defeated Giants (2-7), 3-1 | Candlestick Park (1-0) | 6-3 | |
| » W: Rich Gale (1-0) L: Bill Laskey (0-3) S: Tom Hume (2) | Third | 1½ out |
| Saturday, April 16 |
| » Defeated Giants (2-8), 8-3 | Candlestick Park (2-0) | 7-3 | Won 2 |
| » W: Mario Soto (3-1) L: Fred Breining (2-1) | Third | 1 out |
| Sunday, April 17 |
| » Lost to Giants (3-8), 3-0 | Candlestick Park (2-1) | 7-4 | |
| » W: Atlee Hammaker (1-1) L: Joe Price (1-1) | Third | 1 out |
| » Defeated Giants (3-9), 12-3 | Candlestick Park (3-1) | 8-4 | |
| » W: Frank Pastore (2-1) L: Mark Calvert (0-1) | Third | 1 out |
| Tuesday, April 19 |
| » Lost to Astros (3-10), 6-5 | Astrodome (0-1) | 8-5 | |
| » W: Bill Dawley (2-0) L: Tom Hume (0-1) | Second | 1½ out |
| Wednesday, April 20 |
| » Defeated Astros (3-11), 6-4 | Astrodome (1-1) | 9-5 | |
| » W: Rich Gale (2-0) L: Mike LaCoss (0-1) S: Ted Power (1) | Third | 1 out |
| Thursday, April 21 |
| » Lost to Astros (4-11), 4-3 | Astrodome (1-2) | 9-6 | |
| » W: Frank LaCorte (1-2) L: Tom Hume (0-2) | Third | 1½ out |
| Friday, April 22 |
| » Lost to Expos (8-4), 4-0 | Riverfront Stadium (5-2) | 9-7 | Lost 2 |
| » W: Steve Rogers (2-1) L: Frank Pastore (2-2) | Third | 2½ out |
| Sunday, April 24 |
| » Lost to Expos (9-4), 5-4 | Riverfront Stadium (5-3) | 9-8 | Lost 3 |
| » W: Jeff Reardon (1-0) L: Mario Soto (3-2) S: Bryn Smith (2) | Third | 4 out |
| Tuesday, April 26 |
| » Defeated Mets (4-10), 7-0 | Riverfront Stadium (6-3) | 10-8 | |
| » W: Bruce Berenyi (2-1) L: Tom Seaver (1-1) | Third | 4 out |
| Wednesday, April 27 |
| » Lost to Mets (5-10), 2-1 | Riverfront Stadium (6-4) | 10-9 | |
| » W: Mike Torrez (1-2) L: Joe Price (1-2) S: Jesse Orosco (1) | Third | 4 out |
| Friday, April 29 |
| » Lost to Expos (10-6), 9-6 | Stade Olympique (0-1) | 10-10 | Lost 2 |
| » W: Steve Rogers (3-1) L: Frank Pastore (2-3) S: Jeff Reardon (2) | Third | 4½ out |
| Saturday, April 30 |
| » Defeated Expos (10-7), 4-3 | Stade Olympique (1-1) | 11-10 | |
| » W: Rich Gale (3-0) L: Charlie Lea (2-1) S: Tom Hume (3) | Third | 4 out |
| Sunday, May 1 |
| » Lost to Expos (11-7), 5-4 | Stade Olympique (1-2) | 11-11 | |
| » W: Bill Gullickson (2-3) L: Bruce Berenyi (2-2) S: Bryn Smith (3) | Third | 4½ out |
| » Defeated Expos (11-8), 6-3 | Stade Olympique (2-2) | 12-11 | |
| » W: Joe Price (2-2) L: Ray Burris (0-2) S: Tom Hume (4) | Third | 4½ out |
| Monday, May 2 |
| » Defeated Phillies (12-8), 5-2 | Veteran's Stadium (1-0) | 13-11 | Won 2 |
| » W: Ted Power (1-0) L: Dick Ruthven (1-1) | Third | 4 out |
| Tuesday, May 3 |
| » Lost to Phillies (13-8), 13-7 | Veteran's Stadium (1-1) | 13-12 | |
| » W: Sid Monge (3-0) L: Frank Pastore (2-4) | Third | 5 out |
| Wednesday, May 4 |
| » Lost to Phillies (14-8), 9-4 | Veteran's Stadium (1-2) | 13-13 | Lost 2 |
| » W: Steve Carlton (4-2) L: Rich Gale (3-1) | Fourth | 5 out |
| Friday, May 6 |
| » Lost to Mets (7-15), 7-4 | Shea Stadium (0-1) | 13-14 | Lost 3 |
| » W: Jesse Orosco (1-0) L: Bill Scherrer (0-1) | Third | 6 out |
| » Major-league debuts: Darryl Strawberry (Mets) |
| Saturday, May 7 |
| » Defeated Mets (7-16), 7-5 | Shea Stadium (1-1) | 14-14 | |
| » W: Bruce Berenyi (3-2) L: Mike Torrez (1-4) S: Tom Hume (5) | Third | 6 out |
| Sunday, May 8 |
| » Lost to Mets (8-16), 10-5 | Shea Stadium (1-2) | 14-15 | |
| » W: Jesse Orosco (2-0) L: Rich Gale (3-2) S: Doug Sisk (2) | Third | 7 out |
| Tuesday, May 10 |
| » Lost to Phillies (16-9), 3-1 | Riverfront Stadium (6-5) | 14-16 | Lost 2 |
| » W: Steve Carlton (5-2) L: Ted Power (1-1) | Third | 7½ out |
| Wednesday, May 11 |
| » Defeated Phillies (16-10), 2-0 | Riverfront Stadium (7-5) | 15-16 | |
| » W: Mario Soto (4-2) L: John Denny (3-2) | Third | 7 out |
| Thursday, May 12 |
| » Lost to Giants (14-16), 4-2 | Riverfront Stadium (7-6) | 15-17 | |
| » W: Mike Krukow (1-2) L: Bruce Berenyi (3-3) S: Gary Lavelle (3) | Third | 8 out |
| Friday, May 13 |
| » Lost to Giants (15-16), 8-5 | Riverfront Stadium (7-7) | 15-18 | Lost 2 |
| » W: Fred Breining (4-3) L: Rich Gale (3-3) | Sixth | 8 out |
| Saturday, May 14 |
| » Lost to Giants (16-16), 8-7 | Riverfront Stadium (7-8) | 15-19 | Lost 3 |
| » W: Bill Laskey (4-4) L: Frank Pastore (2-5) S: Greg Minton (4) | Sixth | 9 out |
| Sunday, May 15 |
| » Lost to Giants (17-16), 5-2 | Riverfront Stadium (7-9) | 15-20 | Lost 4 |
| » W: Atlee Hammaker (4-1) L: Tom Hume (0-3) S: Gary Lavelle (4) | Sixth | 10 out |
| Tuesday, May 17 |
| » Defeated Pirates (12-18), 2-1 | Three Rivers Stadium (1-0) | 16-20 | |
| » W: Mario Soto (5-2) L: John Candelaria (3-4) | Fourth | 9 out |
| Wednesday, May 18 |
| » Lost to Pirates (13-18), 2-1 | Three Rivers Stadium (1-1) | 16-21 | |
| » W: Rick Rhoden (2-3) L: Bruce Berenyi (3-4) | Fourth | 10 out |
| Friday, May 20 |
| » Defeated Cubs (13-21), 9-5 | Wrigley Field (1-0) | 17-21 | |
| » W: Bill Scherrer (1-1) L: Mike Proly (1-1) | Fourth | 9 out |
| Saturday, May 21 |
| » Lost to Cubs (14-21), 8-4 | Wrigley Field (1-1) | 17-22 | |
| » W: Paul Moskau (2-2) L: Charlie Puleo (0-1) | Fifth | 9½ out |
| Sunday, May 22 |
| » Defeated Cubs (14-22), 4-3 | Wrigley Field (2-1) | 18-22 | |
| » W: Mario Soto (6-2) L: Chuck Rainey (4-4) | Fourth | 9½ out |
| Monday, May 23 |
| » Defeated Cardinals (19-16), 2-1 | Riverfront Stadium (8-9) | 19-22 | Won 2 |
| » W: Joe Price (3-2) L: Joaquin Andujar (3-6) S: Bill Scherrer (1) | Fourth | 9½ out |
| Tuesday, May 24 |
| » Lost to Cardinals (20-16), 7-1 | Riverfront Stadium (8-10) | 19-23 | |
| » W: Dave LaPoint (3-1) L: Bruce Berenyi (3-5) | Fourth | 10½ out |
| Wednesday, May 25 |
| » Lost to Cardinals (21-16), 7-2 | Riverfront Stadium (8-11) | 19-24 | Lost 2 |
| » W: John Stuper (5-2) L: Ted Power (1-2) | Fourth | 11½ out |
| Thursday, May 26 |
| » Lost to Pirates (16-21), 6-4 | Riverfront Stadium (8-12) | 19-25 | Lost 3 |
| » W: Lee Tunnell (1-1) L: Charlie Puleo (0-2) S: Kent Tekulve (2) | Fourth | 11½ out |
| Friday, May 27 |
| » Defeated Pirates (16-22), 9-0 | Riverfront Stadium (9-12) | 20-25 | |
| » W: Mario Soto (7-2) L: John Candelaria (3-5) | Fourth | 10½ out |
| Saturday, May 28 |
| » Defeated Pirates (16-23), 4-3 | Riverfront Stadium (10-12) | 21-25 | Won 2 |
| » W: Ben Hayes (1-0) L: Rod Scurry (2-2) S: Bill Scherrer (2) | Fourth | 10½ out |
| Sunday, May 29 |
| » Lost to Pirates (17-23), 8-5 | Riverfront Stadium (10-13) | 21-26 | |
| » W: Larry McWilliams (6-3) L: Bill Scherrer (1-2) S: Manny Sarmiento (1) | Fourth | 10½ out |
| Monday, May 30 |
| » Lost to Cardinals (25-17), 9-1 | Busch Stadium II (0-1) | 21-27 | Lost 2 |
| » W: John Stuper (6-2) L: Ted Power (1-3) | Fifth | 11½ out |
| Tuesday, May 31 |
| » Defeated Cardinals (25-18), 2-1 | Busch Stadium II (1-1) | 22-27 | |
| » W: Charlie Puleo (1-2) L: Joaquin Andujar (3-7) S: Bill Scherrer (3) | Fifth | 11½ out |
| Wednesday, June 1 |
| » Lost to Cardinals (26-18), 8-3 | Busch Stadium II (1-2) | 22-28 | |
| » W: John Martin (3-1) L: Mario Soto (7-3) | Fifth | 12½ out |
| Friday, June 3 |
| » Defeated Astros (22-30), 3-1 | Riverfront Stadium (11-13) | 23-28 | |
| » W: Joe Price (4-2) L: Joe Niekro (3-5) | Fifth | 12 out |
| Saturday, June 4 |
| » Lost to Astros (23-30), 13-0 | Riverfront Stadium (11-14) | 23-29 | |
| » W: Mike Scott (1-3) L: Bruce Berenyi (3-6) | Fifth | 13 out |
| Sunday, June 5 |
| » Lost to Astros (24-30), 6-3 | Riverfront Stadium (11-15) | 23-30 | Lost 2 |
| » W: Vern Ruhle (1-1) L: Bill Scherrer (1-3) S: Bill Dawley (4) | Sixth | 13 out |
| Tuesday, June 7 |
| » Lost to Padres (25-27), 7-3 | Riverfront Stadium (11-16) | 23-31 | Lost 3 |
| » W: Eric Show (7-2) L: Mario Soto (7-4) | Sixth | 13 out |
| Wednesday, June 8 |
| » Lost to Padres (26-27), 5-3 | Riverfront Stadium (11-17) | 23-32 | Lost 4 |
| » W: Dave Dravecky (9-3) L: Joe Price (4-3) S: Sid Monge (2) | Sixth | 14 out |
| Thursday, June 9 |
| » Defeated Padres (26-28), 8-1 | Riverfront Stadium (12-17) | 24-32 | |
| » W: Bruce Berenyi (4-6) L: Andy Hawkins (3-4) | Sixth | 14 out |
| Friday, June 10 |
| » Defeated Dodgers (37-18), 3-2 | Riverfront Stadium (13-17) | 25-32 | Won 2 |
| » W: Charlie Puleo (2-2) L: Jerry Reuss (6-5) S: Ben Hayes (1) | Sixth | 13 out |
| Saturday, June 11 |
| » Lost to Dodgers (38-18), 3-2 | Riverfront Stadium (13-18) | 25-33 | |
| » W: Tom Niedenfuer (3-0) L: Ben Hayes (1-1) S: Dave Stewart (7) | Sixth | 14 out |
| Sunday, June 12 |
| » Defeated Dodgers (38-19), 3-1 | Riverfront Stadium (14-18) | 26-33 | |
| » W: Mario Soto (8-4) L: Bob Welch (4-6) | Sixth | 13 out |
| Monday, June 13 |
| » Lost to Dodgers (39-19), 5-1 | Riverfront Stadium (14-19) | 26-34 | |
| » W: Fernando Valenzuela (8-2) L: Joe Price (4-4) | Sixth | 14 out |
| » Major-league debuts: Keefe Cato (Reds) |
| Tuesday, June 14 |
| » Defeated Padres (27-32), 4-3 | San Diego/Jack Murphy Stadium (1-0) | 27-34 | |
| » W: Keefe Cato (1-0) L: Gary Lucas (2-4) S: Bill Scherrer (4) | Sixth | 14 out |
| Wednesday, June 15 |
| » Lost to Padres (28-32), 5-1 | San Diego/Jack Murphy Stadium (1-1) | 27-35 | |
| » W: Ed Whitson (1-4) L: Charlie Puleo (2-3) | Sixth | 14 out |
| Thursday, June 16 |
| » Lost to Padres (29-32), 3-1 | San Diego/Jack Murphy Stadium (1-2) | 27-36 | Lost 2 |
| » W: Tim Lollar (2-4) L: Frank Pastore (2-6) S: John Montefusco (1) | Sixth | 15 out |
| Friday, June 17 |
| » Lost to Dodgers (42-20), 1-0 | Dodger Stadium (0-1) | 27-37 | Lost 3 |
| » W: Bob Welch (5-6) L: Mario Soto (8-5) | Sixth | 16 out |
| Saturday, June 18 |
| » Defeated Dodgers (42-21), 3-2 | Dodger Stadium (1-1) | 28-37 | |
| » W: Joe Price (5-4) L: Fernando Valenzuela (8-3) S: Bill Scherrer (5) | Sixth | 15 out |
| Sunday, June 19 |
| » Lost to Dodgers (43-21), 5-1 | Dodger Stadium (1-2) | 28-38 | |
| » W: Burt Hooton (6-2) L: Bruce Berenyi (4-7) | Sixth | 16 out |
| » Major-league debuts: Nick Esasky (Reds) |
| Monday, June 20 |
| » Lost to Giants (35-31), 4-3 | Candlestick Park (3-2) | 28-39 | Lost 2 |
| » W: Greg Minton (2-3) L: Ted Power (1-4) | Sixth | 16 out |
| Tuesday, June 21 |
| » Defeated Giants (35-32), 6-5 | Candlestick Park (4-2) | 29-39 | |
| » W: Ted Power (2-4) L: Jim Barr (0-1) | Sixth | 15 out |
| Wednesday, June 22 |
| » Defeated Giants (35-33), 4-2 | Candlestick Park (5-2) | 30-39 | Won 2 |
| » W: Mario Soto (9-5) L: Mark Davis (0-1) | Sixth | 14 out |
| Friday, June 24 |
| » Lost to Braves (40-29), 3-0 | Riverfront Stadium (14-20) | 30-40 | |
| » W: Craig McMurtry (8-4) L: Joe Price (5-5) | Sixth | 15 out |
| » Lost to Braves (41-29), 10-5 | Riverfront Stadium (14-21) | 30-41 | Lost 2 |
| » W: Ken Dayley (1-0) L: Bruce Berenyi (4-8) | Sixth | 15 out |
| Saturday, June 25 |
| » Lost to Braves (42-29), 8-2 | Riverfront Stadium (14-22) | 30-42 | Lost 3 |
| » W: Pete Falcone (6-1) L: Charlie Puleo (2-4) | Fifth | 16 out |
| Sunday, June 26 |
| » Lost to Braves (43-29), 5-1 | Riverfront Stadium (14-23) | 30-43 | Lost 4 |
| » W: Phil Niekro (3-6) L: Frank Pastore (2-7) | Sixth | 16 out |
| Monday, June 27 |
| » Lost to Braves (44-29), 2-1 | Riverfront Stadium (14-24) | 30-44 | Lost 5 |
| » W: Pascual Perez (9-2) L: Mario Soto (9-6) | Sixth | 16½ out |
| Tuesday, June 28 |
| » Defeated Giants (38-35), 5-4 | Riverfront Stadium (15-24) | 31-44 | |
| » W: Ted Power (3-4) L: Greg Minton (2-4) S: Ben Hayes (2) | Sixth | 16½ out |
| Wednesday, June 29 |
| » Defeated Giants (38-36), 7-6 | Riverfront Stadium (16-24) | 32-44 | Won 2 |
| » W: Ted Power (4-4) L: Greg Minton (2-5) | Sixth | 15½ out |
| Thursday, June 30 |
| » Defeated Giants (38-37), 15-5 | Riverfront Stadium (17-24) | 33-44 | Won 3 |
| » W: Charlie Puleo (3-4) L: Fred Breining (6-5) S: Ted Power (2) | Fifth | 14½ out |
| Friday, July 1 |
| » Lost to Braves (47-30), 5-2 | Atlanta-Fulton County Stadium (0-3) | 33-45 | |
| » W: Phil Niekro (4-6) L: Frank Pastore (2-8) S: Steve Bedrosian (10) | Sixth | 15½ out |
| Saturday, July 2 |
| » Lost to Braves (48-30), 4-2 | Atlanta-Fulton County Stadium (0-4) | 33-46 | Lost 2 |
| » W: Pascual Perez (10-2) L: Mario Soto (9-7) S: Donnie Moore (3) | Fifth | 15½ out |
| Sunday, July 3 |
| » Defeated Braves (48-31), 2-1 | Atlanta-Fulton County Stadium (1-4) | 34-46 | |
| » W: Joe Price (6-5) L: Craig McMurtry (8-5) S: Ben Hayes (3) | Sixth | 14½ out |
| Monday, July 4 |
| » Lost to Braves (49-31), 9-5 | Atlanta-Fulton County Stadium (1-5) | 34-47 | |
| » W: Pete Falcone (7-1) L: Bruce Berenyi (4-9) S: Donnie Moore (4) | Sixth | 15½ out |
| Friday, July 8 |
| » Defeated Phillies (38-37), 3-1 | Riverfront Stadium (18-24) | 35-47 | |
| » W: Joe Price (7-5) L: John Denny (6-5) S: Bill Scherrer (6) | Sixth | 15½ out |
| Saturday, July 9 |
| » Defeated Phillies (38-38), 2-1 | Riverfront Stadium (19-24) | 36-47 | Won 2 |
| » W: Tom Hume (1-3) L: Willie Hernandez (3-1) | Sixth | 15½ out |
| Sunday, July 10 |
| » Lost to Phillies (39-38), 2-0 | Riverfront Stadium (19-25) | 36-48 | |
| » W: Marty Bystrom (3-4) L: Mario Soto (9-8) S: Al Holland (7) | Fifth | 15½ out |
| Monday, July 11 |
| » Lost to Phillies (40-38), 11-7 | Riverfront Stadium (19-26) | 36-49 | Lost 2 |
| » W: Al Holland (4-0) L: Tom Hume (1-4) | Sixth | 16½ out |
| Tuesday, July 12 |
| » Defeated Mets (31-53), 6-2 | Shea Stadium (2-2) | 37-49 | |
| » W: Frank Pastore (3-8) L: Mike Torrez (5-10) S: Bill Scherrer (7) | Sixth | 15 out |
| Wednesday, July 13 |
| » Defeated Mets (31-54), 3-1 | Shea Stadium (3-2) | 38-49 | Won 2 |
| » W: Joe Price (8-5) L: Walt Terrell (1-4) | Sixth | 15 out |
| Thursday, July 14 |
| » Lost to Mets (32-54), 7-4 | Shea Stadium (3-3) | 38-50 | |
| » W: Tom Seaver (6-9) L: Charlie Puleo (3-5) S: Jesse Orosco (8) | Fifth | 16 out |
| Friday, July 15 |
| » Defeated Phillies (42-41), 3-2 | Veteran's Stadium (2-2) | 39-50 | |
| » W: Mario Soto (10-8) L: Charles Hudson (2-3) | Sixth | 16 out |
| Saturday, July 16 |
| » Lost to Phillies (43-41), 9-3 | Veteran's Stadium (2-3) | 39-51 | |
| » W: John Denny (8-5) L: Bruce Berenyi (4-10) | Sixth | 17 out |
| Sunday, July 17 |
| » Defeated Phillies (43-42), 5-2 | Veteran's Stadium (3-3) | 40-51 | |
| » W: Frank Pastore (4-8) L: Kevin Gross (2-1) | Sixth | 16 out |
| » Major-league debuts: Steve Jeltz (Phillies) |
| Tuesday, July 19 |
| » Defeated Expos (43-45), 5-2 | Stade Olympique (3-2) | 41-51 | Won 2 |
| » W: Joe Price (9-5) L: Steve Rogers (12-5) S: Tom Hume (6) | Sixth | 16½ out |
| Former Red Joe Beggs dies in Indianapolis, IN at the age of 73. |
| Wednesday, July 20 |
| » Lost to Expos (44-45), 6-4 | Stade Olympique (3-3) | 41-52 | |
| » W: Charlie Lea (7-6) L: Mario Soto (10-9) S: Bob James (1) | Sixth | 16½ out |
| Thursday, July 21 |
| » Defeated Mets (34-59), 6-1 | Riverfront Stadium (20-26) | 42-52 | |
| » W: Charlie Puleo (4-5) L: Mike Torrez (5-12) S: Ben Hayes (4) | Sixth | 15½ out |
| Friday, July 22 |
| » Lost to Mets (35-59), 3-2 | Riverfront Stadium (20-27) | 42-53 | |
| » W: Jesse Orosco (5-5) L: Ben Hayes (1-2) S: Doug Sisk (9) | Sixth | 16½ out |
| Saturday, July 23 |
| » Defeated Mets (35-60), 7-3 | Riverfront Stadium (21-27) | 43-53 | |
| » W: Bruce Berenyi (5-10) L: Tom Gorman (0-4) | Sixth | 16½ out |
| Sunday, July 24 |
| » Defeated Mets (35-61), 4-2 | Riverfront Stadium (22-27) | 44-53 | Won 2 |
| » W: Joe Price (10-5) L: Tom Seaver (6-10) | Sixth | 16½ out |
| Monday, July 25 |
| » Defeated Expos (47-47), 4-2 | Riverfront Stadium (23-27) | 45-53 | Won 3 |
| » W: Mario Soto (11-9) L: Charlie Lea (7-7) | Sixth | 16 out |
| » Lost to Expos (48-47), 8-1 | Riverfront Stadium (23-28) | 45-54 | |
| » W: Ray Burris (4-4) L: Rich Gale (3-4) | Sixth | 16 out |
| Tuesday, July 26 |
| » Lost to Expos (49-47), 5-0 | Riverfront Stadium (23-29) | 45-55 | Lost 2 |
| » W: Bill Gullickson (9-10) L: Charlie Puleo (4-6) | Sixth | 16 out |
| Wednesday, July 27 |
| » Lost to Expos (50-47), 6-3 | Riverfront Stadium (23-30) | 45-56 | Lost 3 |
| » W: Greg Bargar (2-0) L: Frank Pastore (4-9) S: Bob James (2) | Sixth | 17 out |
| Friday, July 29 |
| » Lost to Astros (51-49), 4-1 | Astrodome (1-3) | 45-57 | Lost 4 |
| » W: Mike Madden (4-0) L: Joe Price (10-6) S: Dave Smith (4) | Sixth | 17½ out |
| Saturday, July 30 |
| » Defeated Astros (51-50), 3-2 | Astrodome (2-3) | 46-57 | |
| » W: Mario Soto (12-9) L: Nolan Ryan (9-5) | Fifth | 17½ out |
| Sunday, July 31 |
| » Lost to Astros (52-50), 9-2 | Astrodome (2-4) | 46-58 | |
| » W: Joe Niekro (9-8) L: Bruce Berenyi (5-11) | Sixth | 17½ out |
| Monday, August 1 |
| » Defeated Dodgers (57-46), 4-2 | Dodger Stadium (2-2) | 47-58 | |
| » W: Ben Hayes (2-2) L: Bob Welch (8-11) | Sixth | 17½ out |
| Tuesday, August 2 |
| » Lost to Dodgers (58-46), 3-1 | Dodger Stadium (2-3) | 47-59 | |
| » W: Alejandro Pena (9-5) L: Frank Pastore (4-10) | Sixth | 17½ out |
| Wednesday, August 3 |
| » Lost to Dodgers (59-46), 7-4 | Dodger Stadium (2-4) | 47-60 | Lost 2 |
| » W: Pat Zachry (3-0) L: Rich Gale (3-5) S: Tom Niedenfuer (5) | Sixth | 18½ out |
| Thursday, August 4 |
| » Defeated Dodgers (59-47), 4-3 | Dodger Stadium (3-4) | 48-60 | |
| » W: Ben Hayes (3-2) L: Tom Niedenfuer (5-1) | Sixth | 18½ out |
| Friday, August 5 |
| » Defeated Padres (53-55), 4-3 | San Diego/Jack Murphy Stadium (2-2) | 49-60 | Won 2 |
| » W: Ted Power (5-4) L: Elias Sosa (1-2) S: Bill Scherrer (8) | Sixth | 17½ out |
| Saturday, August 6 |
| » Lost to Padres (54-55), 11-4 | San Diego/Jack Murphy Stadium (2-3) | 49-61 | |
| » W: Eric Show (11-7) L: Charlie Puleo (4-7) | Sixth | 18 out |
| » Lost to Padres (55-55), 6-2 | San Diego/Jack Murphy Stadium (2-4) | 49-62 | Lost 2 |
| » W: John Montefusco (9-2) L: Ted Power (5-5) | Sixth | 18 out |
| Sunday, August 7 |
| » Defeated Padres (55-56), 5-3 | San Diego/Jack Murphy Stadium (3-4) | 50-62 | |
| » W: Frank Pastore (5-10) L: Ed Whitson (2-7) | Sixth | 18 out |
| Tuesday, August 9 |
| » Defeated Dodgers (61-49), 5-4 | Riverfront Stadium (24-30) | 51-62 | Won 2 |
| » W: Mario Soto (13-9) L: Steve Howe (4-6) | Sixth | 18 out |
| Wednesday, August 10 |
| » Defeated Dodgers (61-50), 9-2 | Riverfront Stadium (25-30) | 52-62 | Won 3 |
| » W: Bruce Berenyi (6-11) L: Burt Hooton (8-6) | Sixth | 17 out |
| Thursday, August 11 |
| » Lost to Dodgers (62-50), 4-3 | Riverfront Stadium (25-31) | 52-63 | |
| » W: Tom Niedenfuer (6-1) L: Charlie Puleo (4-8) | Sixth | 18 out |
| Friday, August 12 |
| » Defeated Padres (56-59), 6-5 | Riverfront Stadium (26-31) | 53-63 | |
| » W: Frank Pastore (6-10) L: Eric Show (11-8) S: Tom Hume (7) | Sixth | 17 out |
| Saturday, August 13 |
| » Defeated Padres (56-60), 3-1 | Riverfront Stadium (27-31) | 54-63 | Won 2 |
| » W: Jeff Russell (1-0) L: John Montefusco (9-3) | Sixth | 17 out |
| » Major-league debuts: Jeff Russell (Reds) |
| Sunday, August 14 |
| » Lost to Padres (57-60), 10-9 | Riverfront Stadium (27-32) | 54-64 | |
| » W: Luis DeLeon (3-4) L: Tom Hume (1-5) S: Gary Lucas (12) | Sixth | 17 out |
| Monday, August 15 |
| » Lost to Astros (61-55), 9-1 | Riverfront Stadium (27-33) | 54-65 | Lost 2 |
| » W: Bob Knepper (5-11) L: Bruce Berenyi (6-12) | Sixth | 17 out |
| Tuesday, August 16 |
| » Lost to Astros (62-55), 8-5 | Riverfront Stadium (27-34) | 54-66 | Lost 3 |
| » W: Mike Scott (7-4) L: Charlie Puleo (4-9) S: Bill Dawley (11) | Sixth | 17 out |
| Wednesday, August 17 |
| » Lost to Astros (63-55), 7-6 | Riverfront Stadium (27-35) | 54-67 | Lost 4 |
| » W: Vern Ruhle (5-3) L: Frank Pastore (6-11) | Sixth | 17½ out |
| Thursday, August 18 |
| » Defeated Pirates (62-56), 6-5 | Three Rivers Stadium (2-1) | 55-67 | |
| » W: Tom Hume (2-5) L: Kent Tekulve (6-3) S: Ben Hayes (5) | Sixth | 16½ out |
| Friday, August 19 |
| » Defeated Pirates (62-57), 2-1 | Three Rivers Stadium (3-1) | 56-67 | Won 2 |
| » W: Mario Soto (14-9) L: Rick Rhoden (9-10) | Sixth | 16½ out |
| Saturday, August 20 |
| » Lost to Pirates (63-57), 4-0 | Three Rivers Stadium (3-2) | 56-68 | |
| » W: Jose DeLeon (4-2) L: Bruce Berenyi (6-13) | Sixth | 17½ out |
| Sunday, August 21 |
| » Defeated Pirates (63-58), 6-4 | Three Rivers Stadium (4-2) | 57-68 | |
| » W: Bill Scherrer (2-3) L: Cecilio Guante (2-1) | Sixth | 17½ out |
| Monday, August 22 |
| » Lost to Cubs (55-69), 2-0 | Wrigley Field (2-2) | 57-69 | |
| » W: Dickie Noles (5-7) L: Frank Pastore (6-12) S: Lee Smith (20) | Sixth | 18 out |
| » Major-league debuts: Carmelo Martinez (Cubs) |
| Tuesday, August 23 |
| » Defeated Cubs (55-70), 4-2 | Wrigley Field (3-2) | 58-69 | |
| » W: Jeff Russell (2-0) L: Fergie Jenkins (4-9) S: Ben Hayes (6) | Sixth | 17 out |
| Wednesday, August 24 |
| » Lost to Cubs (56-70), 3-0 | Wrigley Field (3-3) | 58-70 | |
| » W: Chuck Rainey (13-10) L: Mario Soto (14-10) | Sixth | 18 out |
| Friday, August 26 |
| » Defeated Cardinals (62-63), 7-3 | Riverfront Stadium (28-35) | 59-70 | |
| » W: Charlie Puleo (5-9) L: Danny Cox (1-2) S: Bill Scherrer (9) | Sixth | 16½ out |
| Saturday, August 27 |
| » Lost to Cardinals (63-63), 3-1 | Riverfront Stadium (28-36) | 59-71 | |
| » W: Dave Rucker (6-3) L: Ted Power (5-6) S: Bruce Sutter (15) | Sixth | 16½ out |
| Sunday, August 28 |
| » Defeated Cardinals (63-64), 5-4 | Riverfront Stadium (29-36) | 60-71 | |
| » W: Ben Hayes (4-2) L: Bruce Sutter (8-9) | Sixth | 16½ out |
| Monday, August 29 |
| » Lost to Pirates (67-62), 2-1 | Riverfront Stadium (29-37) | 60-72 | |
| » W: Rick Rhoden (10-11) L: Mario Soto (14-11) S: Kent Tekulve (16) | Sixth | 17½ out |
| Tuesday, August 30 |
| » Lost to Pirates (68-62), 5-3 | Riverfront Stadium (29-38) | 60-73 | Lost 2 |
| » W: Jose DeLeon (6-2) L: Jeff Russell (2-1) S: Kent Tekulve (17) | Sixth | 18 out |
| Wednesday, August 31 |
| » Defeated Cubs (59-73), 6-4 | Riverfront Stadium (30-38) | 61-73 | |
| » W: Rich Gale (4-5) L: Rich Bordi (0-2) S: Ben Hayes (7) | Sixth | 17 out |
| Thursday, September 1 |
| » Lost to Cubs (60-73), 3-1 | Riverfront Stadium (30-39) | 61-74 | |
| » W: Dick Ruthven (11-10) L: Bruce Berenyi (6-14) S: Lee Smith (23) | Sixth | 17 out |
| » Major-league debuts: Steve Christmas (Reds) |
| Friday, September 2 |
| » Defeated Cardinals (66-66), 4-0 | Busch Stadium II (2-2) | 62-74 | |
| » W: Frank Pastore (7-12) L: John Stuper (9-9) | Sixth | 17 out |
| Saturday, September 3 |
| » Defeated Cardinals (66-67), 3-2 | Busch Stadium II (3-2) | 63-74 | Won 2 |
| » W: Mario Soto (15-11) L: Dave Rucker (6-4) | Sixth | 17 out |
| Sunday, September 4 |
| » Lost to Cardinals (67-67), 5-4 | Busch Stadium II (3-3) | 63-75 | |
| » W: Jeff Lahti (3-1) L: Ben Hayes (4-3) | Sixth | 17 out |
| Monday, September 5 |
| » Lost to Giants (66-72), 3-2 | Candlestick Park (5-3) | 63-76 | Lost 2 |
| » W: Fred Breining (9-11) L: Jeff Russell (2-2) S: Greg Minton (19) | Sixth | 17 out |
| » Major-league debuts: Dan Gladden (Giants) |
| Tuesday, September 6 |
| » Defeated Giants (66-73), 11-1 | Candlestick Park (6-3) | 64-76 | |
| » W: Bruce Berenyi (7-14) L: Atlee Hammaker (10-9) S: Rich Gale (1) | Sixth | 16 out |
| » Major-league debuts: Skeeter Barnes (Reds) |
| Wednesday, September 7 |
| » Lost to Dodgers (80-59), 7-3 | Dodger Stadium (3-5) | 64-77 | |
| » W: Tom Niedenfuer (8-2) L: Ben Hayes (4-4) | Sixth | 17 out |
| Thursday, September 8 |
| » Lost to Dodgers (81-59), 5-2 | Dodger Stadium (3-6) | 64-78 | Lost 2 |
| » W: Bob Welch (14-11) L: Mario Soto (15-12) S: Steve Howe (17) | Sixth | 18 out |
| Friday, September 9 |
| » Lost to Padres (71-72), 8-2 | San Diego/Jack Murphy Stadium (3-5) | 64-79 | Lost 3 |
| » W: Andy Hawkins (4-6) L: Charlie Puleo (5-10) | Sixth | 19 out |
| Sunday, September 11 |
| » Defeated Padres (71-73), 4-2 | San Diego/Jack Murphy Stadium (4-5) | 65-79 | |
| » W: Jeff Russell (3-2) L: Mark Thurmond (7-3) S: Tom Hume (8) | Sixth | 18½ out |
| » Major-league debuts: Greg Booker (Padres) |
| Tuesday, September 13 |
| » Defeated Braves (80-64), 6-0 | Riverfront Stadium (31-39) | 66-79 | Won 2 |
| » W: Mario Soto (16-12) L: Pascual Perez (13-8) | Sixth | 18½ out |
| Wednesday, September 14 |
| » Defeated Braves (80-65), 6-4 | Riverfront Stadium (32-39) | 67-79 | Won 3 |
| » W: Frank Pastore (8-12) L: Phil Niekro (10-9) | Sixth | 17½ out |
| Friday, September 16 |
| » Defeated Astros (76-70), 8-3 | Riverfront Stadium (33-39) | 68-79 | Won 4 |
| » W: Bruce Berenyi (8-14) L: Jeff Heathcock (1-1) | Sixth | 17 out |
| Saturday, September 17 |
| » Lost to Astros (77-70), 4-3 | Riverfront Stadium (33-40) | 68-80 | |
| » W: Mike Madden (8-4) L: Jeff Russell (3-3) S: Frank DiPino (17) | Sixth | 17 out |
| Sunday, September 18 |
| » Lost to Astros (78-70), 4-1 | Riverfront Stadium (33-41) | 68-81 |