| Tuesday, April 5 |
| » Defeated Giants (0-1), 16-13 | Candlestick Park (1-0) | 1-0 | |
| » W: Tim Lollar (1-0) L: Mike Krukow (0-1) S: Gary Lucas (1) | First | -- |
| Wednesday, April 6 |
| » Defeated Giants (0-2), 5-3 | Candlestick Park (2-0) | 2-0 | Won 2 |
| » W: Dave Dravecky (1-0) L: Bill Laskey (0-1) | First | -- |
| Friday, April 8 |
| » Lost to Braves (2-1), 4-2 | Atlanta-Fulton County Stadium (0-1) | 2-1 | |
| » W: Steve Bedrosian (1-1) L: Floyd Chiffer (0-1) S: Gene Garber (1) | First | -- |
| Saturday, April 9 |
| » Lost to Braves (3-1), 6-5 | Atlanta-Fulton County Stadium (0-2) | 2-2 | Lost 2 |
| » W: Pete Falcone (1-0) L: Chris Welsh (0-1) | Second | 1 out |
| Sunday, April 10 |
| » Lost to Braves (4-1), 4-3 | Atlanta-Fulton County Stadium (0-3) | 2-3 | Lost 3 |
| » W: Craig McMurtry (1-0) L: Ed Whitson (0-1) S: Steve Bedrosian (1) | Third | 2 out |
| » Major-league debuts: Craig McMurtry (Braves) |
| Monday, April 11 |
| » Lost to Braves (5-1), 4-0 | Atlanta-Fulton County Stadium (0-4) | 2-4 | Lost 4 |
| » W: Pascual Perez (2-0) L: Tim Lollar (1-1) | Third | 3 out |
| Tuesday, April 12 |
| » Lost to Giants (2-4), 6-5 | San Diego/Jack Murphy Stadium (0-1) | 2-5 | Lost 5 |
| » W: Fred Breining (2-0) L: Dave Dravecky (1-1) S: Greg Minton (2) | Fourth | 4 out |
| Wednesday, April 13 |
| » Defeated Giants (2-5), 2-1 | San Diego/Jack Murphy Stadium (1-1) | 3-5 | |
| » W: Eric Show (1-0) L: Atlee Hammaker (0-1) S: Gary Lucas (2) | Fourth | 4 out |
| Thursday, April 14 |
| » Defeated Giants (2-6), 6-4 | San Diego/Jack Murphy Stadium (2-1) | 4-5 | Won 2 |
| » W: John Montefusco (1-0) L: Andy McGaffigan (0-1) S: Gary Lucas (3) | Fourth | 3½ out |
| Friday, April 15 |
| » Lost to Dodgers (7-2), 6-2 | Dodger Stadium (0-1) | 4-6 | |
| » W: Fernando Valenzuela (2-0) L: Ed Whitson (0-2) S: Joe Beckwith (1) | Fourth | 4 out |
| Saturday, April 16 |
| » Lost to Dodgers (8-2), 8-5 | Dodger Stadium (0-2) | 4-7 | Lost 2 |
| » W: Jerry Reuss (2-0) L: Floyd Chiffer (0-2) S: Dave Stewart (2) | Fourth | 4½ out |
| Sunday, April 17 |
| » Defeated Dodgers (8-3), 9-1 | Dodger Stadium (1-2) | 5-7 | |
| » W: Dave Dravecky (2-1) L: Bob Welch (0-2) | Fourth | 4 out |
| Monday, April 18 |
| » Defeated Braves (8-3), 10-3 | San Diego/Jack Murphy Stadium (3-1) | 6-7 | Won 2 |
| » W: Eric Show (2-0) L: Craig McMurtry (1-1) S: Luis DeLeon (1) | Fourth | 3½ out |
| Tuesday, April 19 |
| » Lost to Braves (9-3), 9-2 | San Diego/Jack Murphy Stadium (3-2) | 6-8 | |
| » W: Rick Camp (2-0) L: John Montefusco (1-1) | Third | 4 out |
| Friday, April 22 |
| » Defeated Cardinals (6-3), 4-1 | Busch Stadium II (1-0) | 7-8 | |
| » W: Dave Dravecky (3-1) L: Bob Forsch (1-2) | Fourth | 4 out |
| Saturday, April 23 |
| » Lost to Cardinals (7-3), 9-5 | Busch Stadium II (1-1) | 7-9 | |
| » W: John Martin (1-0) L: Eric Show (2-1) | Fourth | 4½ out |
| Sunday, April 24 |
| » Lost to Cardinals (8-3), 2-0 | Busch Stadium II (1-2) | 7-10 | Lost 2 |
| » W: Dave LaPoint (2-0) L: Andy Hawkins (0-1) S: Bruce Sutter (2) | Fourth | 6 out |
| Tuesday, April 26 |
| » Defeated Cubs (4-12), 10-8 | Wrigley Field (1-0) | 8-10 | |
| » W: John Montefusco (2-1) L: Craig Lefferts (0-1) S: Luis DeLeon (2) | Fourth | 6 out |
| Wednesday, April 27 |
| » Lost to Cubs (5-12), 5-4 | Wrigley Field (1-1) | 8-11 | |
| » W: Bill Campbell (1-0) L: Gary Lucas (0-1) | Fourth | 6 out |
| Thursday, April 28 |
| » Defeated Cubs (5-13), 3-1 | Wrigley Field (2-1) | 9-11 | |
| » W: Eric Show (3-1) L: Steve Trout (1-4) S: Luis DeLeon (3) | Fourth | 5½ out |
| Saturday, April 30 |
| » Defeated Pirates (7-9), 8-4 | Three Rivers Stadium (1-0) | 10-11 | Won 2 |
| » W: Andy Hawkins (1-1) L: John Candelaria (2-2) | Fourth | 5½ out |
| » Lost to Pirates (8-9), 2-1 | Three Rivers Stadium (1-1) | 10-12 | |
| » W: Larry McWilliams (3-2) L: Luis DeLeon (0-1) S: Rod Scurry (2) | Fourth | 5½ out |
| Tuesday, May 3 |
| » Defeated Cardinals (11-7), 4-3 | San Diego/Jack Murphy Stadium (4-2) | 11-12 | |
| » W: Dave Dravecky (4-1) L: Bob Forsch (1-3) S: Gary Lucas (4) | Fourth | 6 out |
| Wednesday, May 4 |
| » Defeated Cardinals (11-8), 10-0 | San Diego/Jack Murphy Stadium (5-2) | 12-12 | Won 2 |
| » W: Eric Show (4-1) L: Joaquin Andujar (2-4) | Third | 5 out |
| Thursday, May 5 |
| » Lost to Cardinals (12-8), 4-3 | San Diego/Jack Murphy Stadium (5-3) | 12-13 | |
| » W: Bruce Sutter (3-0) L: Gary Lucas (0-2) | Fourth | 6 out |
| Friday, May 6 |
| » Lost to Cubs (7-17), 3-2 | San Diego/Jack Murphy Stadium (5-4) | 12-14 | Lost 2 |
| » W: Chuck Rainey (2-3) L: Tim Lollar (1-2) S: Lee Smith (3) | Fourth | 6½ out |
| Saturday, May 7 |
| » Lost to Cubs (8-17), 6-4 | San Diego/Jack Murphy Stadium (5-5) | 12-15 | Lost 3 |
| » W: Bill Campbell (2-1) L: Gary Lucas (0-3) | Fourth | 7½ out |
| Sunday, May 8 |
| » Defeated Cubs (8-18), 5-3 | San Diego/Jack Murphy Stadium (6-5) | 13-15 | |
| » W: Dave Dravecky (5-1) L: Warren Brusstar (0-1) | Fourth | 7½ out |
| Monday, May 9 |
| » Lost to Pirates (10-14), 5-3 | San Diego/Jack Murphy Stadium (6-6) | 13-16 | |
| » W: Manny Sarmiento (1-1) L: Mike Couchee (0-1) | Fifth | 8½ out |
| Tuesday, May 10 |
| » Defeated Pirates (10-15), 4-1 | San Diego/Jack Murphy Stadium (7-6) | 14-16 | |
| » W: Andy Hawkins (2-1) L: Rod Scurry (2-1) | Third | 7½ out |
| Thursday, May 12 |
| » Lost to Dodgers (22-8), 4-3 | San Diego/Jack Murphy Stadium (7-7) | 14-17 | |
| » W: Fernando Valenzuela (4-2) L: Luis DeLeon (0-2) S: Dave Stewart (4) | Fifth | 8½ out |
| Friday, May 13 |
| » Defeated Dodgers (22-9), 6-4 | San Diego/Jack Murphy Stadium (8-7) | 15-17 | |
| » W: Dave Dravecky (6-1) L: Burt Hooton (1-2) S: Luis DeLeon (4) | Fourth | 7½ out |
| Saturday, May 14 |
| » Lost to Dodgers (23-9), 4-1 | San Diego/Jack Murphy Stadium (8-8) | 15-18 | |
| » W: Jerry Reuss (5-1) L: Eric Show (4-2) | Fourth | 8½ out |
| » Major-league debuts: Mark Thurmond (Padres) |
| Sunday, May 15 |
| » Lost to Dodgers (24-9), 3-2 | San Diego/Jack Murphy Stadium (8-9) | 15-19 | Lost 2 |
| » W: Bob Welch (2-3) L: Andy Hawkins (2-2) S: Steve Howe (7) | Fourth | 9½ out |
| Tuesday, May 17 |
| » Lost to Mets (12-20), 6-4 | Shea Stadium (0-1) | 15-20 | Lost 3 |
| » W: Tom Seaver (3-2) L: Tim Lollar (1-3) S: Doug Sisk (3) | Fifth | 9½ out |
| Wednesday, May 18 |
| » Lost to Mets (13-20), 2-1 | Shea Stadium (0-2) | 15-21 | Lost 4 |
| » W: Mike Torrez (2-5) L: Dave Dravecky (6-2) S: Doug Sisk (4) | Fifth | 10½ out |
| Thursday, May 19 |
| » Defeated Mets (13-21), 3-2 | Shea Stadium (1-2) | 16-21 | |
| » W: Eric Show (5-2) L: Scott Holman (0-2) S: Luis DeLeon (5) | Fourth | 10 out |
| Friday, May 20 |
| » Defeated Phillies (18-14), 5-0 | Veteran's Stadium (1-0) | 17-21 | Won 2 |
| » W: Andy Hawkins (3-2) L: Steve Carlton (6-3) | Fourth | 9 out |
| Monday, May 23 |
| » Lost to Expos (19-17), 3-1 | Stade Olympique (0-1) | 17-22 | |
| » W: Bill Gullickson (4-5) L: Dave Dravecky (6-3) S: Jeff Reardon (4) | Fifth | 10½ out |
| Tuesday, May 24 |
| » Lost to Expos (20-17), 5-4 | Stade Olympique (0-2) | 17-23 | Lost 2 |
| » W: Jeff Reardon (2-1) L: Luis DeLeon (0-3) | Fifth | 11½ out |
| Wednesday, May 25 |
| » Lost to Expos (21-17), 2-0 | Stade Olympique (0-3) | 17-24 | Lost 3 |
| » W: Steve Rogers (7-1) L: Andy Hawkins (3-3) | Sixth | 12½ out |
| Friday, May 27 |
| » Defeated Mets (15-25), 4-0 | San Diego/Jack Murphy Stadium (9-9) | 18-24 | |
| » W: Eric Show (6-2) L: Tom Seaver (3-4) | Fifth | 11 out |
| Saturday, May 28 |
| » Defeated Mets (15-26), 5-4 | San Diego/Jack Murphy Stadium (10-9) | 19-24 | Won 2 |
| » W: Dave Dravecky (7-3) L: Mike Torrez (2-6) S: Gary Lucas (5) | Fifth | 11 out |
| Sunday, May 29 |
| » Lost to Mets (16-26), 3-2 | San Diego/Jack Murphy Stadium (10-10) | 19-25 | |
| » W: Ed Lynch (3-2) L: Tim Lollar (1-4) S: Jesse Orosco (3) | Fifth | 11 out |
| Monday, May 30 |
| » Defeated Expos (22-20), 5-4 | San Diego/Jack Murphy Stadium (11-10) | 20-25 | |
| » W: Gary Lucas (1-3) L: Steve Rogers (7-2) | Fourth | 11 out |
| Tuesday, May 31 |
| » Defeated Expos (22-21), 5-3 | San Diego/Jack Murphy Stadium (12-10) | 21-25 | Won 2 |
| » W: John Montefusco (3-1) L: Jeff Reardon (2-3) | Fourth | 11 out |
| Wednesday, June 1 |
| » Lost to Expos (23-21), 8-6 | San Diego/Jack Murphy Stadium (12-11) | 21-26 | |
| » W: Bryn Smith (1-2) L: Elias Sosa (0-1) | Fourth | 12 out |
| Thursday, June 2 |
| » Defeated Phillies (20-22), 4-1 | San Diego/Jack Murphy Stadium (13-11) | 22-26 | |
| » W: Dave Dravecky (8-3) L: Ed Farmer (0-2) | Fourth | 12 out |
| » Major-league debuts: Kevin McReynolds (Padres) |
| Friday, June 3 |
| » Defeated Phillies (20-23), 8-5 | San Diego/Jack Murphy Stadium (14-11) | 23-26 | Won 2 |
| » W: Gary Lucas (2-3) L: Ed Farmer (0-3) | Fourth | 11 out |
| Saturday, June 4 |
| » Defeated Phillies (20-24), 5-4 | San Diego/Jack Murphy Stadium (15-11) | 24-26 | Won 3 |
| » W: John Montefusco (4-1) L: Marty Bystrom (0-3) S: Sid Monge (1) | Fourth | 11 out |
| Sunday, June 5 |
| » Lost to Phillies (21-24), 2-1 | San Diego/Jack Murphy Stadium (15-12) | 24-27 | |
| » W: Al Holland (1-0) L: Ed Whitson (0-3) | Fourth | 11 out |
| Tuesday, June 7 |
| » Defeated Reds (23-31), 7-3 | Riverfront Stadium (1-0) | 25-27 | |
| » W: Eric Show (7-2) L: Mario Soto (7-4) | Fourth | 10 out |
| Wednesday, June 8 |
| » Defeated Reds (23-32), 5-3 | Riverfront Stadium (2-0) | 26-27 | Won 2 |
| » W: Dave Dravecky (9-3) L: Joe Price (4-3) S: Sid Monge (2) | Fourth | 10 out |
| Thursday, June 9 |
| » Lost to Reds (24-32), 8-1 | Riverfront Stadium (2-1) | 26-28 | |
| » W: Bruce Berenyi (4-6) L: Andy Hawkins (3-4) | Fourth | 11 out |
| Friday, June 10 |
| » Lost to Astros (28-30), 2-1 | Astrodome (0-1) | 26-29 | Lost 2 |
| » W: Mike LaCoss (4-4) L: Ed Whitson (0-4) S: Bill Dawley (5) | Fifth | 11 out |
| Saturday, June 11 |
| » Defeated Astros (28-31), 8-4 | Astrodome (1-1) | 27-29 | |
| » W: John Montefusco (5-1) L: Vern Ruhle (1-2) | Fourth | 11 out |
| Sunday, June 12 |
| » Lost to Astros (29-31), 2-0 | Astrodome (1-2) | 27-30 | |
| » W: Nolan Ryan (4-1) L: Eric Show (7-3) | Fifth | 11 out |
| Monday, June 13 |
| » Lost to Astros (30-31), 2-0 | Astrodome (1-3) | 27-31 | Lost 2 |
| » W: Joe Niekro (4-5) L: Dave Dravecky (9-4) S: Frank DiPino (5) | Fifth | 12 out |
| Tuesday, June 14 |
| » Lost to Reds (27-34), 4-3 | San Diego/Jack Murphy Stadium (15-13) | 27-32 | Lost 3 |
| » W: Keefe Cato (1-0) L: Gary Lucas (2-4) S: Bill Scherrer (4) | Fifth | 13 out |
| Wednesday, June 15 |
| » Defeated Reds (27-35), 5-1 | San Diego/Jack Murphy Stadium (16-13) | 28-32 | |
| » W: Ed Whitson (1-4) L: Charlie Puleo (2-3) | Fifth | 12 out |
| Thursday, June 16 |
| » Defeated Reds (27-36), 3-1 | San Diego/Jack Murphy Stadium (17-13) | 29-32 | Won 2 |
| » W: Tim Lollar (2-4) L: Frank Pastore (2-6) S: John Montefusco (1) | Fifth | 12 out |
| Friday, June 17 |
| » Lost to Astros (33-32), 4-1 | San Diego/Jack Murphy Stadium (17-14) | 29-33 | |
| » W: Nolan Ryan (5-1) L: Eric Show (7-4) S: Bill Dawley (6) | Fifth | 13 out |
| Saturday, June 18 |
| » Defeated Astros (33-33), 2-1 | San Diego/Jack Murphy Stadium (18-14) | 30-33 | |
| » W: Dave Dravecky (10-4) L: Frank LaCorte (4-3) | Fifth | 12 out |
| Sunday, June 19 |
| » Defeated Astros (33-34), 6-4 | San Diego/Jack Murphy Stadium (19-14) | 31-33 | Won 2 |
| » W: Elias Sosa (1-1) L: Bob Knepper (2-9) S: Sid Monge (3) | Fifth | 12 out |
| Monday, June 20 |
| » Defeated Dodgers (43-22), 4-1 | Dodger Stadium (2-2) | 32-33 | Won 3 |
| » W: Ed Whitson (2-4) L: Jerry Reuss (6-6) S: John Montefusco (2) | Fourth | 11 out |
| Tuesday, June 21 |
| » Defeated Dodgers (43-23), 2-0 | Dodger Stadium (3-2) | 33-33 | Won 4 |
| » W: Tim Lollar (3-4) L: Alejandro Pena (6-2) S: Luis DeLeon (6) | Fourth | 10 out |
| Wednesday, June 22 |
| » Defeated Dodgers (43-24), 5-2 | Dodger Stadium (4-2) | 34-33 | Won 5 |
| » W: Eric Show (8-4) L: Bob Welch (5-7) S: Gary Lucas (6) | Fourth | 9 out |
| Thursday, June 23 |
| » Defeated Dodgers (43-25), 7-5 | Dodger Stadium (5-2) | 35-33 | Won 6 |
| » W: Dave Dravecky (11-4) L: Fernando Valenzuela (8-4) S: Gary Lucas (7) | Third | 8 out |
| Friday, June 24 |
| » Lost to Giants (36-33), 5-0 | Candlestick Park (2-1) | 35-34 | |
| » W: Mike Krukow (5-4) L: Andy Hawkins (3-5) | Fourth | 9 out |
| Saturday, June 25 |
| » Defeated Giants (36-34), 3-2 | Candlestick Park (3-1) | 36-34 | |
| » W: John Montefusco (6-1) L: Gary Lavelle (5-2) S: Gary Lucas (8) | Third | 9 out |
| Sunday, June 26 |
| » Lost to Giants (37-34), 2-0 | Candlestick Park (3-2) | 36-35 | |
| » W: Atlee Hammaker (9-3) L: Tim Lollar (3-5) | Fourth | 9½ out |
| » Lost to Giants (38-34), 4-3 | Candlestick Park (3-3) | 36-36 | Lost 2 |
| » W: Bill Laskey (8-7) L: Eric Show (8-5) S: Gary Lavelle (11) | Fourth | 9½ out |
| Tuesday, June 28 |
| » Lost to Dodgers (46-26), 9-5 | San Diego/Jack Murphy Stadium (19-15) | 36-37 | Lost 3 |
| » W: Bob Welch (6-7) L: Dave Dravecky (11-5) | Fifth | 10½ out |
| Wednesday, June 29 |
| » Defeated Dodgers (46-27), 13-2 | San Diego/Jack Murphy Stadium (20-15) | 37-37 | |
| » W: Mark Thurmond (1-0) L: Fernando Valenzuela (8-5) | Fourth | 9½ out |
| Thursday, June 30 |
| » Defeated Dodgers (46-28), 7-6 | San Diego/Jack Murphy Stadium (21-15) | 38-37 | Won 2 |
| » W: John Montefusco (7-1) L: Steve Howe (2-2) | Third | 8½ out |
| Friday, July 1 |
| » Lost to Giants (39-37), 4-3 | San Diego/Jack Murphy Stadium (21-16) | 38-38 | |
| » W: Bill Laskey (9-7) L: Tim Lollar (3-6) S: Jim Barr (2) | Fourth | 9½ out |
| Saturday, July 2 |
| » Defeated Giants (39-38), 5-4 | San Diego/Jack Murphy Stadium (22-16) | 39-38 | |
| » W: Gary Lucas (3-4) L: Atlee Hammaker (9-4) | Third | 8½ out |
| Sunday, July 3 |
| » Defeated Giants (39-39), 4-1 | San Diego/Jack Murphy Stadium (23-16) | 40-38 | Won 2 |
| » W: Dave Dravecky (12-5) L: Mark Davis (0-2) | Third | 7½ out |
| Monday, July 4 |
| » Defeated Giants (39-40), 4-3 | San Diego/Jack Murphy Stadium (24-16) | 41-38 | Won 3 |
| » W: Mark Thurmond (2-0) L: Mike Krukow (5-5) S: Gary Lucas (9) | Third | 7½ out |
| Friday, July 8 |
| » Defeated Cardinals (40-40), 3-2 | San Diego/Jack Murphy Stadium (25-16) | 42-38 | Won 4 |
| » W: Gary Lucas (4-4) L: Bruce Sutter (7-4) | Third | 7½ out |
| Saturday, July 9 |
| » Lost to Cardinals (41-40), 12-4 | San Diego/Jack Murphy Stadium (25-17) | 42-39 | |
| » W: Dave LaPoint (6-6) L: Dave Dravecky (12-6) | Third | 8½ out |
| Sunday, July 10 |
| » Lost to Cardinals (42-40), 4-2 | San Diego/Jack Murphy Stadium (25-18) | 42-40 | Lost 2 |
| » W: Dave VonOhlen (2-2) L: Gary Lucas (4-5) S: Bruce Sutter (8) | Third | 8½ out |
| Monday, July 11 |
| » Defeated Cubs (39-45), 6-5 | San Diego/Jack Murphy Stadium (26-18) | 43-40 | |
| » W: John Montefusco (8-1) L: Fergie Jenkins (3-5) S: Sid Monge (4) | Third | 8½ out |
| Tuesday, July 12 |
| » Defeated Cubs (39-46), 5-3 | San Diego/Jack Murphy Stadium (27-18) | 44-40 | Won 2 |
| » W: Eric Show (9-5) L: Dickie Noles (2-5) | Third | 7 out |
| Wednesday, July 13 |
| » Defeated Cubs (39-47), 5-4 | San Diego/Jack Murphy Stadium (28-18) | 45-40 | Won 3 |
| » W: Tim Lollar (4-6) L: Chuck Rainey (9-8) S: Gary Lucas (10) | Third | 7 out |
| Thursday, July 14 |
| » Lost to Pirates (40-43), 8-6 | San Diego/Jack Murphy Stadium (28-19) | 45-41 | |
| » W: Cecilio Guante (2-0) L: John Montefusco (8-2) S: Jim Bibby (2) | Third | 8 out |
| Friday, July 15 |
| » Lost to Pirates (41-43), 4-2 | San Diego/Jack Murphy Stadium (28-20) | 45-42 | Lost 2 |
| » W: Kent Tekulve (4-2) L: Mark Thurmond (2-1) | Fourth | 9 out |
| Saturday, July 16 |
| » Lost to Pirates (42-43), 3-2 | San Diego/Jack Murphy Stadium (28-21) | 45-43 | Lost 3 |
| » W: Don Robinson (2-1) L: Ed Whitson (2-5) S: Kent Tekulve (9) | Fourth | 10 out |
| Sunday, July 17 |
| » Lost to Pirates (43-43), 4-3 | San Diego/Jack Murphy Stadium (28-22) | 45-44 | Lost 4 |
| » W: Lee Tunnell (4-3) L: Eric Show (9-6) S: Kent Tekulve (10) | Fourth | 10 out |
| Tuesday, July 19 |
| » Lost to Cardinals (46-44), 4-0 | Busch Stadium II (1-3) | 45-45 | Lost 5 |
| » W: Neil Allen (6-8) L: Tim Lollar (4-7) | Fourth | 11½ out |
| Wednesday, July 20 |
| » Defeated Cardinals (46-45), 5-4 | Busch Stadium II (2-3) | 46-45 | |
| » W: Luis DeLeon (1-3) L: Bruce Sutter (7-6) S: Sid Monge (5) | Fourth | 10½ out |
| Thursday, July 21 |
| » Defeated Cardinals (46-46), 4-2 | Busch Stadium II (3-3) | 47-45 | Won 2 |
| » W: Mark Thurmond (3-1) L: Joaquin Andujar (4-13) S: Luis DeLeon (7) | Fourth | 9½ out |
| Friday, July 22 |
| » Lost to Cubs (43-51), 7-3 | Wrigley Field (2-2) | 47-46 | |
| » W: Craig Lefferts (3-3) L: Gary Lucas (4-6) | Fourth | 10½ out |
| Saturday, July 23 |
| » Defeated Cubs (43-52), 4-2 | Wrigley Field (3-2) | 48-46 | |
| » W: Eric Show (10-6) L: Dickie Noles (3-6) S: John Montefusco (3) | Fourth | 10½ out |
| Sunday, July 24 |
| » Lost to Cubs (44-52), 5-2 | Wrigley Field (3-3) | 48-47 | |
| » W: Chuck Rainey (10-8) L: Tim Lollar (4-8) S: Lee Smith (14) | Fourth | 11½ out |
| Monday, July 25 |
| » Lost to Pirates (49-46), 6-3 | Three Rivers Stadium (1-2) | 48-48 | Lost 2 |
| » W: Rick Rhoden (8-8) L: Dave Dravecky (12-7) S: Cecilio Guante (3) | Fourth | 11½ out |
| Tuesday, July 26 |
| » Defeated Pirates (49-47), 6-1 | Three Rivers Stadium (2-2) | 49-48 | |
| » W: Mark Thurmond (4-1) L: Don Robinson (2-2) S: Luis DeLeon (8) | Fourth | 11 out |
| » Lost to Pirates (50-47), 10-5 | Three Rivers Stadium (2-3) | 49-49 | |
| » W: Lee Tunnell (5-3) L: Ed Whitson (2-6) | Fourth | 11 out |
| Wednesday, July 27 |
| » Lost to Pirates (51-47), 10-1 | Three Rivers Stadium (2-4) | 49-50 | Lost 2 |
| » W: Jose DeLeon (2-0) L: Eric Show (10-7) | Fourth | 12 out |
| Friday, July 29 |
| » Lost to Braves (63-39), 2-1 | San Diego/Jack Murphy Stadium (28-23) | 49-51 | Lost 3 |
| » W: Pascual Perez (12-2) L: Tim Lollar (4-9) S: Gene Garber (6) | Fourth | 12 out |
| » Defeated Braves (63-40), 6-5 | San Diego/Jack Murphy Stadium (29-23) | 50-51 | |
| » W: Sid Monge (4-0) L: Donnie Moore (2-3) | Fourth | 12 out |
| Saturday, July 30 |
| » Lost to Braves (64-40), 5-2 | San Diego/Jack Murphy Stadium (29-24) | 50-52 | |
| » W: Phil Niekro (6-6) L: Dave Dravecky (12-8) | Fourth | 13 out |
| Sunday, July 31 |
| » Defeated Braves (64-41), 5-2 | San Diego/Jack Murphy Stadium (30-24) | 51-52 | |
| » W: Mark Thurmond (5-1) L: Craig McMurtry (12-6) S: John Montefusco (4) | Fourth | 12 out |
| Monday, August 1 |
| » Defeated Astros (52-51), 7-4 | San Diego/Jack Murphy Stadium (31-24) | 52-52 | Won 2 |
| » W: Luis DeLeon (2-3) L: Bill Dawley (5-4) | Fourth | 12 out |
| Tuesday, August 2 |
| » Lost to Astros (53-51), 4-2 | San Diego/Jack Murphy Stadium (31-25) | 52-53 | |
| » W: Vern Ruhle (3-3) L: Sid Monge (4-1) | Fourth | 12 out |
| Wednesday, August 3 |
| » Lost to Astros (54-51), 1-0 | San Diego/Jack Murphy Stadium (31-26) | 52-54 | Lost 2 |
| » W: Nolan Ryan (10-5) L: Tim Lollar (4-10) | Fourth | 13 out |
| Thursday, August 4 |
| » Defeated Astros (54-52), 4-2 | San Diego/Jack Murphy Stadium (32-26) | 53-54 | |
| » W: Dave Dravecky (13-8) L: Joe Niekro (9-9) S: Gary Lucas (11) | Fourth | 13 out |
| Friday, August 5 |
| » Lost to Reds (49-60), 4-3 | San Diego/Jack Murphy Stadium (32-27) | 53-55 | |
| » W: Ted Power (5-4) L: Elias Sosa (1-2) S: Bill Scherrer (8) | Fourth | 13 out |
| Saturday, August 6 |
| » Defeated Reds (49-61), 11-4 | San Diego/Jack Murphy Stadium (33-27) | 54-55 | |
| » W: Eric Show (11-7) L: Charlie Puleo (4-7) | Fourth | 11½ out |
| » Defeated Reds (49-62), 6-2 | San Diego/Jack Murphy Stadium (34-27) | 55-55 | Won 2 |
| » W: John Montefusco (9-2) L: Ted Power (5-5) | Fourth | 11½ out |
| Sunday, August 7 |
| » Lost to Reds (50-62), 5-3 | San Diego/Jack Murphy Stadium (34-28) | 55-56 | |
| » W: Frank Pastore (5-10) L: Ed Whitson (2-7) | Fourth | 12½ out |
| Tuesday, August 9 |
| » Defeated Astros (56-54), 3-2 | Astrodome (2-3) | 56-56 | |
| » W: Tim Lollar (5-10) L: Joe Niekro (9-10) S: Sid Monge (6) | Fourth | 12½ out |
| Wednesday, August 10 |
| » Lost to Astros (57-54), 4-3 | Astrodome (2-4) | 56-57 | |
| » W: Vern Ruhle (4-3) L: Luis DeLeon (2-4) | Fourth | 12½ out |
| Thursday, August 11 |
| » Lost to Astros (58-54), 5-1 | Astrodome (2-5) | 56-58 | Lost 2 |
| » W: Mike Scott (6-4) L: Mark Thurmond (5-2) S: Dave Smith (5) | Fourth | 13½ out |
| Friday, August 12 |
| » Lost to Reds (53-63), 6-5 | Riverfront Stadium (2-2) | 56-59 | Lost 3 |
| » W: Frank Pastore (6-10) L: Eric Show (11-8) S: Tom Hume (7) | Fourth | 13½ out |
| Saturday, August 13 |
| » Lost to Reds (54-63), 3-1 | Riverfront Stadium (2-3) | 56-60 | Lost 4 |
| » W: Jeff Russell (1-0) L: John Montefusco (9-3) | Fourth | 14½ out |
| » Major-league debuts: Jeff Russell (Reds) |
| Sunday, August 14 |
| » Defeated Reds (54-64), 10-9 | Riverfront Stadium (3-3) | 57-60 | |
| » W: Luis DeLeon (3-4) L: Tom Hume (1-5) S: Gary Lucas (12) | Fourth | 13½ out |
| Monday, August 15 |
| » Defeated Braves (71-48), 4-0 | Atlanta-Fulton County Stadium (1-4) | 58-60 | Won 2 |
| » W: Dave Dravecky (14-8) L: Craig McMurtry (12-8) | Fourth | 12½ out |
| Tuesday, August 16 |
| » Defeated Braves (71-49), 3-2 | Atlanta-Fulton County Stadium (2-4) | 59-60 | Won 3 |
| » W: Sid Monge (5-1) L: Steve Bedrosian (8-6) S: Ed Whitson (1) | Fourth | 11½ out |
| Wednesday, August 17 |
| » Defeated Phillies (62-54), 5-4 | San Diego/Jack Murphy Stadium (35-28) | 60-60 | Won 4 |
| » W: Eric Show (12-8) L: Charles Hudson (7-5) S: Gary Lucas (13) | Fourth | 11 out |
| Thursday, August 18 |
| » Lost to Phillies (63-54), 4-2 | San Diego/Jack Murphy Stadium (35-29) | 60-61 | |
| » W: Al Holland (7-1) L: Gary Lucas (4-7) S: Ron Reed (6) | Fourth | 11 out |
| Friday, August 19 |
| » Defeated Expos (60-59), 6-5 | San Diego/Jack Murphy Stadium (36-29) | 61-61 | |
| » W: Tim Lollar (6-10) L: Ray Burris (4-5) S: Sid Monge (7) | Fourth | 11 out |
| Sunday, August 21 |
| » Lost to Expos (61-59), 3-0 | San Diego/Jack Murphy Stadium (36-30) | 61-62 | |
| » W: Charlie Lea (11-8) L: Dave Dravecky (14-9) | Fourth | 12 out |
| » Defeated Expos (61-60), 5-2 | San Diego/Jack Murphy Stadium (37-30) | 62-62 | |
| » W: Mark Thurmond (6-2) L: Bill Gullickson (11-11) S: Luis DeLeon (9) | Fourth | 12 out |
| Monday, August 22 |
| » Defeated Mets (51-72), 4-3 | San Diego/Jack Murphy Stadium (38-30) | 63-62 | Won 2 |
| » W: Eric Show (13-8) L: Craig Swan (2-7) S: Luis DeLeon (10) | Fourth | 11½ out |
| Tuesday, August 23 |
| » Lost to Mets (52-72), 8-3 | San Diego/Jack Murphy Stadium (38-31) | 63-63 | |
| » W: Walt Terrell (5-5) L: John Montefusco (9-4) | Fourth | 11½ out |
| Wednesday, August 24 |
| » Defeated Mets (52-73), 3-2 | San Diego/Jack Murphy Stadium (39-31) | 64-63 | |
| » W: Tim Lollar (7-10) L: Tom Seaver (7-12) S: Luis DeLeon (11) | Fourth | 11½ out |
| Friday, August 26 |
| » Lost to Expos (62-63), 10-4 | Stade Olympique (0-4) | 64-64 | |
| » W: Bill Gullickson (12-11) L: Dave Dravecky (14-10) | Fourth | 11 out |
| Saturday, August 27 |
| » Lost to Expos (63-63), 6-4 | Stade Olympique (0-5) | 64-65 | Lost 2 |
| » W: Charlie Lea (12-8) L: Luis DeLeon (3-5) S: Dan Schatzeder (2) | Fourth | 11 out |
| Sunday, August 28 |
| » Lost to Expos (64-63), 8-0 | Stade Olympique (0-6) | 64-66 | Lost 3 |
| » W: Steve Rogers (16-8) L: Eric Show (13-9) | Fourth | 12 out |
| Monday, August 29 |
| » Defeated Phillies (64-63), 6-5 | Veteran's Stadium (2-0) | 65-66 | |
| » W: Luis DeLeon (4-5) L: Steve Carlton (12-14) | Fourth | 12½ out |
| » Lost to Phillies (65-63), 8-6 | Veteran's Stadium (2-1) | 65-67 | |
| » W: Steve Comer (1-0) L: Sid Monge (5-2) S: Al Holland (16) | Fourth | 12½ out |
| Tuesday, August 30 |
| » Lost to Phillies (66-63), 6-0 | Veteran's Stadium (2-2) | 65-68 | Lost 2 |
| » W: Kevin Gross (4-4) L: Andy Hawkins (3-6) | Fourth | 12½ out |
| » Defeated Phillies (66-64), 7-5 | Veteran's Stadium (3-2) | 66-68 | |
| » W: Ed Whitson (3-7) L: Tug McGraw (1-1) S: Luis DeLeon (12) | Fourth | 12½ out |
| Wednesday, August 31 |
| » Lost to Phillies (67-64), 4-3 | Veteran's Stadium (3-3) | 66-69 | |
| » W: Al Holland (8-2) L: Elias Sosa (1-3) | Fourth | 12½ out |
| Friday, September 2 |
| » Lost to Mets (56-78), 7-3 | Shea Stadium (1-3) | 66-70 | Lost 2 |
| » W: Walt Terrell (6-6) L: Eric Show (13-10) | Fourth | 13 out |
| Saturday, September 3 |
| » Lost to Mets (57-78), 4-3 | Shea Stadium (1-4) | 66-71 | Lost 3 |
| » W: Tom Gorman (1-4) L: Elias Sosa (1-4) | Fourth | 14 out |
| Sunday, September 4 |
| » Defeated Mets (57-79), 7-5 | Shea Stadium (2-4) | 67-71 | |
| » W: Sid Monge (6-2) L: Ed Lynch (9-9) S: Elias Sosa (1) | Fourth | 13 out |
| Monday, September 5 |
| » Defeated Dodgers (79-58), 5-2 | Dodger Stadium (6-2) | 68-71 | Won 2 |
| » W: Mark Thurmond (7-2) L: Fernando Valenzuela (13-9) S: Gary Lucas (14) | Fourth | 12 out |
| Tuesday, September 6 |
| » Defeated Dodgers (79-59), 8-3 | Dodger Stadium (7-2) | 69-71 | Won 3 |
| » W: Ed Whitson (4-7) L: Rick Honeycutt (16-10) | Fourth | 11 out |
| Wednesday, September 7 |
| » Defeated Astros (72-66), 8-7 | San Diego/Jack Murphy Stadium (40-31) | 70-71 | Won 4 |
| » W: Sid Monge (7-2) L: Frank DiPino (3-4) | Fourth | 11 out |
| Thursday, September 8 |
| » Lost to Astros (73-66), 3-2 | San Diego/Jack Murphy Stadium (40-32) | 70-72 | |
| » W: Mike Madden (7-4) L: Luis DeLeon (4-6) S: Vern Ruhle (2) | Fourth | 12 out |
| Friday, September 9 |
| » Defeated Reds (64-79), 8-2 | San Diego/Jack Murphy Stadium (41-32) | 71-72 | |
| » W: Andy Hawkins (4-6) L: Charlie Puleo (5-10) | Fourth | 12 out |
| Sunday, September 11 |
| » Lost to Reds (65-79), 4-2 | San Diego/Jack Murphy Stadium (41-33) | 71-73 | |
| » W: Jeff Russell (3-2) L: Mark Thurmond (7-3) S: Tom Hume (8) | Fourth | 12½ out |
| » Major-league debuts: Greg Booker (Padres) |
| Tuesday, September 13 |
| » Defeated Giants (68-77), 4-3 | San Diego/Jack Murphy Stadium (42-33) | 72-73 | |
| » W: Sid Monge (8-2) L: Greg Minton (7-11) | Fourth | 12½ out |
| Wednesday, September 14 |
| » Defeated Giants (68-78), 7-4 | San Diego/Jack Murphy Stadium (43-33) | 73-73 | Won 2 |
| » W: Eric Show (14-10) L: Mike Krukow (10-9) S: Gary Lucas (15) | Fourth | 11½ out |
| Friday, September 16 |
| » Lost to Braves (81-65), 6-0 | Atlanta-Fulton County Stadium (2-5) | 73-74 | |
| » W: Craig McMurtry (13-9) L: Tim Lollar (7-11) | Fourth | 12 out |
| » Major-league debuts: Dennis Rasmussen (Padres) |
| Saturday, September 17 |
| » Defeated Braves (81-66), 2-1 | Atlanta-Fulton County Stadium (3-5) | 74-74 | |
| » W: Luis DeLeon (5-6) L: Len Barker (9-15) S: Gary Lucas (16) | Fourth | 11 out |
| Sunday, September 18 |
| » Defeated Braves (81-67), 4-2 | Atlanta-Fulton County Stadium (4-5) | 75-74 | Won 2 |
| » W: Gary Lucas (5-7) L: Ken Dayley (4-6) | Fourth | 10 out |
| Monday, September 19 |
| » Defeated Giants (71-79), 4-2 | Candlestick Park (4-3) | 76-74 | Won 3 |
| » W: Ed Whitson (5-7) L: Scott Garrelts (1-1) S: Floyd Chiffer (1) | Fourth | 10 out |
| Tuesday, September 20 |
| » Lost to Giants (72-79), 8-1 | Candlestick Park (4-4) | 76-75 | |
| » W: Mark Calvert (1-3) L: Eric Show (14-11) S: Andy McGaffigan (2) | Fourth | 10 out |
| Wednesday, September 21 |
| » Lost to Giants (73-79), 5-4 | Candlestick Park (4-5) | 76-76 | Lost 2 |
| » W: Gary Lavelle (7-4) L: Gary Lucas (5-8) | Fourth | 11 out |
| Friday, September 23 |
| » Defeated Reds (70-83), 11-8 | Riverfront Stadium (4-3) | 77-76 | |
| » W: Luis DeLeon (6-6) L: Ben Hayes (4-5) | Fourth | 11 out |
| Saturday, September 24 |
| » Lost to Reds (71-83), 3-2 | Riverfront Stadium (4-4) | 77-77 | |
| » W: Bruce Berenyi (9-14) L: Sid Monge (8-3) | Fourth | |