| Wednesday, January 26 |
| Former Oriole Del Rice dies in Buena Park, CA at the age of 61. |
| Monday, April 4 |
| » Lost to Royals (1-0), 7-2 | Memorial Stadium (0-1) | 0-1 | |
| » W: Larry Gura (1-0) L: Dennis Martinez (0-1) | Third | 1 out |
| Wednesday, April 6 |
| » Defeated Royals (1-1), 11-1 | Memorial Stadium (1-1) | 1-1 | |
| » W: Mike Flanagan (1-0) L: Dennis Leonard (0-1) | Third | 1 out |
| Saturday, April 9 |
| » Lost to Indians (3-1), 8-4 | Cleveland Stadium (0-1) | 1-2 | |
| » W: Rick Sutcliffe (2-0) L: Sammy Stewart (0-1) S: Dan Spillner (2) | Fourth | 1½ out |
| Sunday, April 10 |
| » Defeated Indians (3-2), 13-2 | Cleveland Stadium (1-1) | 2-2 | |
| » W: Dennis Martinez (1-1) L: Lary Sorensen (0-1) | Second | ½ out |
| Tuesday, April 12 |
| » Defeated White Sox (2-4), 10-8 | Comiskey Park I (1-0) | 3-2 | Won 2 |
| » W: Sammy Stewart (1-1) L: Dennis Lamp (1-1) | First | -- |
| Thursday, April 14 |
| » Lost to White Sox (3-4), 12-11 | Comiskey Park I (1-1) | 3-3 | |
| » W: Salome Barojas (1-0) L: Don Welchel (0-1) S: Kevin Hickey (2) | Second | ½ out |
| Saturday, April 16 |
| » Defeated Indians (4-4), 2-0 | Memorial Stadium (2-1) | 4-3 | |
| » W: Jim Palmer (1-0) L: Lary Sorensen (0-2) S: Tippy Martinez (1) | Second | ½ out |
| » Lost to Indians (5-4), 7-4 | Memorial Stadium (2-2) | 4-4 | |
| » W: Neal Heaton (1-0) L: Dennis Martinez (1-2) S: Dan Spillner (4) | Second | ½ out |
| Sunday, April 17 |
| » Defeated Indians (5-5), 6-1 | Memorial Stadium (3-2) | 5-4 | |
| » W: Mike Flanagan (2-0) L: Bert Blyleven (0-3) | First | -- |
| Monday, April 18 |
| » Defeated Indians (5-6), 4-1 | Memorial Stadium (4-2) | 6-4 | Won 2 |
| » W: Scott McGregor (1-0) L: Len Barker (2-1) | First | -- |
| Tuesday, April 19 |
| » Defeated Rangers (7-5), 4-2 | Memorial Stadium (5-2) | 7-4 | Won 3 |
| » W: Sammy Stewart (2-1) L: Charlie Hough (1-1) | First | -- |
| Wednesday, April 20 |
| » Lost to Rangers (8-5), 11-2 | Memorial Stadium (5-3) | 7-5 | |
| » W: Mike Smithson (2-0) L: Dennis Martinez (1-3) | First | -- |
| Thursday, April 21 |
| » Defeated Rangers (8-6), 3-2 | Memorial Stadium (6-3) | 8-5 | |
| » W: Tim Stoddard (1-0) L: Odell Jones (1-1) | First | -- |
| Friday, April 22 |
| » Lost to Angels (10-6), 6-5 | Anaheim Stadium (0-1) | 8-6 | |
| » W: Luis Sanchez (1-0) L: Don Welchel (0-2) | First | -- |
| Saturday, April 23 |
| » Defeated Angels (10-7), 3-1 | Anaheim Stadium (1-1) | 9-6 | |
| » W: Scott McGregor (2-0) L: Tommy John (2-1) | First | -- |
| Sunday, April 24 |
| » Lost to Angels (11-7), 7-3 | Anaheim Stadium (1-2) | 9-7 | |
| » W: Mike Witt (1-3) L: Dennis Martinez (1-4) | First | -- |
| Tuesday, April 26 |
| » Lost to Athletics (10-8), 4-3 | Oakland-Alameda County Stadium (0-1) | 9-8 | Lost 2 |
| » W: Chris Codiroli (2-1) L: Jim Palmer (1-1) S: Tom Burgmeier (2) | Third | ½ out |
| Wednesday, April 27 |
| » Defeated Athletics (10-9), 6-0 | Oakland-Alameda County Stadium (1-1) | 10-8 | |
| » W: Mike Flanagan (3-0) L: Bill Krueger (2-2) S: Sammy Stewart (1) | Second | ½ out |
| Friday, April 29 |
| » Defeated Mariners (7-16), 9-1 | Kingdome (1-0) | 11-8 | Won 2 |
| » W: Scott McGregor (3-0) L: Jim Beattie (0-1) | First | -- |
| Saturday, April 30 |
| » Lost to Mariners (8-16), 6-2 | Kingdome (1-1) | 11-9 | |
| » W: Bob Stoddard (2-3) L: Dennis Martinez (1-5) S: Ed Vande Berg (1) | First | -- |
| Sunday, May 1 |
| » Defeated Mariners (8-17), 8-2 | Kingdome (2-1) | 12-9 | |
| » W: Storm Davis (1-0) L: Gaylord Perry (2-3) S: Tippy Martinez (2) | First | -- |
| Tuesday, May 3 |
| » Defeated Angels (13-10), 4-2 | Memorial Stadium (7-3) | 13-9 | Won 2 |
| » W: Mike Flanagan (4-0) L: Geoff Zahn (3-2) | First | -- |
| Wednesday, May 4 |
| » Lost to Angels (14-10), 16-8 | Memorial Stadium (7-4) | 13-10 | |
| » W: Luis Sanchez (2-1) L: Scott McGregor (3-1) | Second | ½ out |
| Friday, May 6 |
| » Defeated Athletics (13-12), 9-2 | Memorial Stadium (8-4) | 14-10 | |
| » W: Dennis Martinez (2-5) L: Mike Norris (3-2) | Second | ½ out |
| Saturday, May 7 |
| » Defeated Athletics (13-13), 8-6 | Memorial Stadium (9-4) | 15-10 | Won 2 |
| » W: Mike Flanagan (5-0) L: Chris Codiroli (3-2) S: Tippy Martinez (3) | Second | ½ out |
| Sunday, May 8 |
| » Lost to Athletics (14-13), 1-0 | Memorial Stadium (9-5) | 15-11 | |
| » W: Bill Krueger (3-3) L: Tippy Martinez (0-1) S: Dave Beard (4) | Second | ½ out |
| Monday, May 9 |
| » Lost to Mariners (11-20), 6-4 | Memorial Stadium (9-6) | 15-12 | Lost 2 |
| » W: Jim Beattie (2-1) L: Scott McGregor (3-2) S: Bill Caudill (6) | Second | 1½ out |
| Tuesday, May 10 |
| » Defeated Mariners (11-21), 13-2 | Memorial Stadium (10-6) | 16-12 | |
| » W: Dennis Martinez (3-5) L: Edwin Nunez (0-4) | Second | ½ out |
| Wednesday, May 11 |
| » Defeated Mariners (11-22), 1-0 | Memorial Stadium (11-6) | 17-12 | Won 2 |
| » W: Mike Flanagan (6-0) L: Gaylord Perry (2-4) | First | -- |
| Friday, May 13 |
| » Defeated Rangers (16-14), 8-1 | Arlington Stadium (1-0) | 18-12 | Won 3 |
| » W: Storm Davis (2-0) L: Charlie Hough (2-3) | First | -- |
| Saturday, May 14 |
| » Defeated Rangers (16-15), 14-11 | Arlington Stadium (2-0) | 19-12 | Won 4 |
| » W: Tippy Martinez (1-1) L: Dave Tobik (0-1) S: Tim Stoddard (1) | First | -- |
| Sunday, May 15 |
| » Lost to Rangers (17-15), 2-1 | Arlington Stadium (2-1) | 19-13 | |
| » W: Danny Darwin (2-3) L: Dennis Martinez (3-6) S: Odell Jones (5) | First | -- |
| Tuesday, May 17 |
| » Defeated White Sox (13-18), 7-2 | Memorial Stadium (12-6) | 20-13 | |
| » W: Tim Stoddard (2-0) L: La Marr Hoyt (2-6) | First | -- |
| » Defeated White Sox (13-19), 5-0 | Memorial Stadium (13-6) | 21-13 | Won 2 |
| » W: Mike Boddicker (1-0) L: Dennis Lamp (3-3) | First | -- |
| Wednesday, May 18 |
| » Defeated White Sox (13-20), 1-0 | Memorial Stadium (14-6) | 22-13 | Won 3 |
| » W: Tippy Martinez (2-1) L: Richard Dotson (4-4) | First | -- |
| Thursday, May 19 |
| » Defeated Blue Jays (18-16), 2-1 | Exhibition Stadium (1-0) | 23-13 | Won 4 |
| » W: Scott McGregor (4-2) L: Mike Morgan (0-3) S: Tippy Martinez (4) | First | -- |
| Friday, May 20 |
| » Lost to Blue Jays (19-16), 7-5 | Exhibition Stadium (1-1) | 23-14 | |
| » W: Jim Gott (1-3) L: Dennis Martinez (3-7) S: Joey McLaughlin (2) | First | -- |
| Saturday, May 21 |
| » Lost to Blue Jays (20-16), 6-0 | Exhibition Stadium (1-2) | 23-15 | Lost 2 |
| » W: Dave Stieb (8-2) L: Sammy Stewart (2-2) | First | -- |
| Sunday, May 22 |
| » Lost to Blue Jays (21-16), 5-0 | Exhibition Stadium (1-3) | 23-16 | Lost 3 |
| » W: Jim Clancy (4-2) L: Mike Boddicker (1-1) | First | -- |
| Monday, May 23 |
| » Lost to Twins (19-23), 12-4 | Memorial Stadium (14-7) | 23-17 | Lost 4 |
| » W: Frank Viola (2-2) L: Storm Davis (2-1) | Second | 1 out |
| Tuesday, May 24 |
| » Lost to Twins (20-23), 6-1 | Memorial Stadium (14-8) | 23-18 | Lost 5 |
| » W: Bobby Castillo (2-3) L: Scott McGregor (4-3) | Third | 1 out |
| Wednesday, May 25 |
| » Lost to Twins (21-23), 7-4 | Memorial Stadium (14-9) | 23-19 | Lost 6 |
| » W: Ken Schrom (3-0) L: Dennis Martinez (3-8) S: Ron Davis (7) | Second | 1 out |
| Thursday, May 26 |
| » Lost to Royals (19-18), 8-2 | Royals Stadium (0-1) | 23-20 | Lost 7 |
| » W: Steve Renko (4-3) L: Mike Boddicker (1-2) | Fourth | 2 out |
| Friday, May 27 |
| » Defeated Royals (19-19), 7-4 | Royals Stadium (1-1) | 24-20 | |
| » W: Storm Davis (3-1) L: Larry Gura (4-6) S: Tippy Martinez (5) | Third | 2 out |
| Saturday, May 28 |
| » Defeated Royals (19-20), 1-0 | Royals Stadium (2-1) | 25-20 | Won 2 |
| » W: Scott McGregor (5-3) L: Mike Armstrong (2-2) | Third | 1 out |
| Sunday, May 29 |
| » Lost to Royals (20-20), 4-0 | Royals Stadium (2-2) | 25-21 | |
| » W: Paul Splittorff (2-1) L: Dennis Martinez (3-9) S: Dan Quisenberry (11) | Second | 1 out |
| Monday, May 30 |
| » Defeated Twins (21-28), 6-1 | Hubert H. Humphrey Metrodome (1-0) | 26-21 | |
| » W: Mike Boddicker (2-2) L: Bobby Castillo (2-4) | Third | 1 out |
| Tuesday, May 31 |
| » Lost to Twins (22-28), 10-3 | Hubert H. Humphrey Metrodome (1-1) | 26-22 | |
| » W: Ken Schrom (4-0) L: Storm Davis (3-2) | Fourth | 1½ out |
| Wednesday, June 1 |
| » Defeated Twins (22-29), 6-3 | Hubert H. Humphrey Metrodome (2-1) | 27-22 | |
| » W: Scott McGregor (6-3) L: Rick Lysander (1-5) S: Tippy Martinez (6) | Third | 1½ out |
| Friday, June 3 |
| » Defeated Blue Jays (27-21), 3-2 | Memorial Stadium (15-9) | 28-22 | Won 2 |
| » W: Tippy Martinez (3-1) L: Joey McLaughlin (1-2) | Second | 1 out |
| Saturday, June 4 |
| » Defeated Blue Jays (27-22), 6-4 | Memorial Stadium (16-9) | 29-22 | Won 3 |
| » W: Mike Boddicker (3-2) L: Dave Stieb (8-4) S: Sammy Stewart (2) | Second | 1 out |
| Sunday, June 5 |
| » Lost to Blue Jays (28-22), 5-2 | Memorial Stadium (16-10) | 29-23 | |
| » W: Jim Clancy (5-4) L: Storm Davis (3-3) S: Joey McLaughlin (5) | Second | 1 out |
| Monday, June 6 |
| » Defeated Blue Jays (28-23), 8-1 | Memorial Stadium (17-10) | 30-23 | |
| » W: Scott McGregor (7-3) L: Luis Leal (5-4) | First | -- |
| Tuesday, June 7 |
| » Defeated Brewers (26-25), 6-4 | Memorial Stadium (18-10) | 31-23 | Won 2 |
| » W: Dennis Martinez (4-9) L: Mike Caldwell (5-5) S: Tippy Martinez (7) | First | -- |
| Wednesday, June 8 |
| » Defeated Brewers (26-26), 7-3 | Memorial Stadium (19-10) | 32-23 | Won 3 |
| » W: Tim Stoddard (3-0) L: Tom Tellmann (3-2) | First | -- |
| Thursday, June 9 |
| » Defeated Brewers (26-27), 10-7 | Memorial Stadium (20-10) | 33-23 | Won 4 |
| » W: Mike Boddicker (4-2) L: Jerry Augustine (2-2) S: Tippy Martinez (8) | First | -- |
| Friday, June 10 |
| » Defeated Red Sox (28-27), 3-0 | Fenway Park (1-0) | 34-23 | Won 5 |
| » W: Storm Davis (4-3) L: Bruce Hurst (4-5) | First | -- |
| Saturday, June 11 |
| » Defeated Red Sox (28-28), 10-6 | Fenway Park (2-0) | 35-23 | Won 6 |
| » W: Scott McGregor (8-3) L: Bob Ojeda (3-2) | First | -- |
| Sunday, June 12 |
| » Lost to Red Sox (29-28), 7-6 | Fenway Park (2-1) | 35-24 | |
| » W: Bob Stanley (5-3) L: Tippy Martinez (3-2) | First | -- |
| Monday, June 13 |
| » Defeated Brewers (28-29), 3-2 | County Stadium (1-0) | 36-24 | |
| » W: Allan Ramirez (1-0) L: Don Sutton (4-4) S: Tippy Martinez (9) | First | -- |
| Wednesday, June 15 |
| » Defeated Brewers (28-30), 11-8 | County Stadium (2-0) | 37-24 | Won 2 |
| » W: Tippy Martinez (4-2) L: Bob Gibson (1-1) | First | -- |
| Thursday, June 16 |
| » Lost to Brewers (29-30), 2-1 | County Stadium (2-1) | 37-25 | |
| » W: Jim Slaton (6-2) L: Tim Stoddard (3-1) | First | -- |
| Friday, June 17 |
| » Lost to Red Sox (31-30), 5-3 | Memorial Stadium (20-11) | 37-26 | Lost 2 |
| » W: Bob Ojeda (4-2) L: Dennis Martinez (4-10) S: Bob Stanley (13) | First | -- |
| Saturday, June 18 |
| » Lost to Red Sox (32-30), 3-2 | Memorial Stadium (20-12) | 37-27 | Lost 3 |
| » W: John Tudor (4-4) L: Tippy Martinez (4-3) | First | -- |
| Sunday, June 19 |
| » Defeated Red Sox (32-31), 6-3 | Memorial Stadium (21-12) | 38-27 | |
| » W: Jim Palmer (2-1) L: Mike Brown (5-4) | First | -- |
| Tuesday, June 21 |
| » Defeated Yankees (34-31), 5-2 | Memorial Stadium (22-12) | 39-27 | Won 2 |
| » W: Tippy Martinez (5-3) L: Shane Rawley (7-6) | First | -- |
| Wednesday, June 22 |
| » Lost to Yankees (35-31), 5-2 | Memorial Stadium (22-13) | 39-28 | |
| » W: Ron Guidry (10-4) L: Scott McGregor (8-4) | First | -- |
| Friday, June 24 |
| » Lost to Tigers (38-30), 9-0 | Memorial Stadium (22-14) | 39-29 | Lost 2 |
| » W: Dan Petry (7-5) L: Dennis Martinez (4-11) | First | -- |
| Saturday, June 25 |
| » Lost to Tigers (39-30), 9-3 | Memorial Stadium (22-15) | 39-30 | Lost 3 |
| » W: Doug Bair (2-1) L: Jim Palmer (2-2) | First | -- |
| Sunday, June 26 |
| » Defeated Tigers (39-31), 3-1 | Memorial Stadium (23-15) | 40-30 | |
| » W: Storm Davis (5-3) L: Jack Morris (8-6) S: Tippy Martinez (10) | First | -- |
| Monday, June 27 |
| » Lost to Yankees (37-33), 4-3 | Yankee Stadium (0-1) | 40-31 | |
| » W: Rich Gossage (4-2) L: Tim Stoddard (3-2) | Second | ½ out |
| Wednesday, June 29 |
| » Lost to Yankees (38-33), 7-0 | Yankee Stadium (0-2) | 40-32 | Lost 2 |
| » W: Dave Righetti (9-3) L: Mike Boddicker (4-3) | Second | 1 out |
| Thursday, June 30 |
| » Lost to Yankees (39-33), 4-3 | Yankee Stadium (0-3) | 40-33 | Lost 3 |
| » W: Rich Gossage (5-2) L: Tim Stoddard (3-3) | Second | 2 out |
| » Major-league debuts: Ray Fontenot (Yankees) |
| Friday, July 1 |
| » Defeated Tigers (40-34), 9-5 | Tiger Stadium (1-0) | 41-33 | |
| » W: Storm Davis (6-3) L: Milt Wilcox (7-8) | Second | 1 out |
| Saturday, July 2 |
| » Defeated Tigers (40-35), 7-2 | Tiger Stadium (2-0) | 42-33 | Won 2 |
| » W: Scott McGregor (9-4) L: Dan Petry (7-6) | Second | 1 out |
| Sunday, July 3 |
| » Lost to Tigers (41-35), 10-1 | Tiger Stadium (2-1) | 42-34 | |
| » W: Juan Berenguer (4-1) L: Mike Boddicker (4-4) S: Doug Bair (3) | Second | 1 out |
| Friday, July 8 |
| » Lost to Mariners (31-51), 3-0 | Memorial Stadium (23-16) | 42-35 | Lost 2 |
| » W: Jim Beattie (7-5) L: Storm Davis (6-4) | Second | 2 out |
| Saturday, July 9 |
| » Lost to Mariners (32-51), 3-2 | Memorial Stadium (23-17) | 42-36 | Lost 3 |
| » W: Bill Caudill (2-5) L: Sammy Stewart (2-3) | Second | 3 out |
| Sunday, July 10 |
| » Defeated Mariners (32-52), 2-0 | Memorial Stadium (24-17) | 43-36 | |
| » W: Mike Boddicker (5-4) L: Matt Young (7-9) | Second | 3 out |
| Monday, July 11 |
| » Defeated Athletics (38-46), 7-6 | Memorial Stadium (25-17) | 44-36 | Won 2 |
| » W: Dennis Martinez (5-11) L: Steve Baker (3-3) S: Dan Morogiello (1) | Second | 3 out |
| Tuesday, July 12 |
| » Defeated Athletics (38-47), 3-1 | Memorial Stadium (26-17) | 45-36 | Won 3 |
| » W: Allan Ramirez (2-0) L: Gorman Heimueller (0-1) S: Tim Stoddard (2) | Second | 3 out |
| Wednesday, July 13 |
| » Defeated Athletics (38-48), 6-2 | Memorial Stadium (27-17) | 46-36 | Won 4 |
| » W: Storm Davis (7-4) L: Tim Conroy (2-2) S: Sammy Stewart (3) | Second | 2 out |
| Thursday, July 14 |
| » Defeated Angels (44-41), 5-1 | Memorial Stadium (28-17) | 47-36 | Won 5 |
| » W: Scott McGregor (10-4) L: Ken Forsch (8-6) | Second | 2 out |
| Friday, July 15 |
| » Defeated Angels (44-42), 10-4 | Memorial Stadium (29-17) | 48-36 | Won 6 |
| » W: Mike Boddicker (6-4) L: Tommy John (7-6) | Second | 2 out |
| Saturday, July 16 |
| » Lost to Angels (45-42), 8-5 | Memorial Stadium (29-18) | 48-37 | |
| » W: Geoff Zahn (6-4) L: Dennis Martinez (5-12) S: Luis Sanchez (5) | Second | 3 out |
| Sunday, July 17 |
| » Defeated Angels (45-43), 11-1 | Memorial Stadium (30-18) | 49-37 | |
| » W: Allan Ramirez (3-0) L: Byron McLaughlin (1-2) | Second | 2 out |
| Monday, July 18 |
| » Defeated Mariners (36-56), 9-4 | Kingdome (3-1) | 50-37 | Won 2 |
| » W: Storm Davis (8-4) L: Jim Beattie (8-6) | Second | 2 out |
| Tuesday, July 19 |
| » Defeated Mariners (36-57), 8-1 | Kingdome (4-1) | 51-37 | Won 3 |
| » W: Scott McGregor (11-4) L: Glenn Abbott (3-2) | Second | 1 out |
| Wednesday, July 20 |
| » Defeated Mariners (36-58), 4-2 | Kingdome (5-1) | 52-37 | Won 4 |
| » W: Sammy Stewart (3-3) L: Matt Young (8-10) S: Tim Stoddard (3) | First | -- |
| Thursday, July 21 |
| » Lost to Athletics (42-52), 9-7 | Oakland-Alameda County Stadium (1-2) | 52-38 | |
| » W: Dave Beard (3-3) L: Dan Morogiello (0-1) S: Tom Burgmeier (4) | First | -- |
| Friday, July 22 |
| » Lost to Athletics (43-52), 4-3 | Oakland-Alameda County Stadium (1-3) | 52-39 | Lost 2 |
| » W: Tom Burgmeier (5-5) L: Allan Ramirez (3-1) | Second | 1 out |
| Saturday, July 23 |
| » Defeated Athletics (43-53), 7-3 | Oakland-Alameda County Stadium (2-3) | 53-39 | |
| » W: Storm Davis (9-4) L: Tim Conroy (2-4) | Second | 1 out |
| Sunday, July 24 |
| » Defeated Athletics (43-54), 4-3 | Oakland-Alameda County Stadium (3-3) | 54-39 | Won 2 |
| » W: Scott McGregor (12-4) L: Steve McCatty (3-5) | First | -- |
| Monday, July 25 |
| » Lost to Angels (48-49), 5-2 | Anaheim Stadium (1-3) | 54-40 | |
| » W: Tommy John (8-7) L: Mike Boddicker (6-5) S: Andy Hassler (3) | First | -- |
| Tuesday, July 26 |
| » Defeated Angels (48-50), 5-4 | Anaheim Stadium (2-3) | 55-40 | |
| » W: Dennis Martinez (6-12) L: Geoff Zahn (7-5) | First | -- |
| Wednesday, July 27 |
| » Defeated Angels (48-51), 10-4 | Anaheim Stadium (3-3) | 56-40 | Won 2 |
| » W: Allan Ramirez (4-1) L: Mike Witt (4-8) S: Sammy Stewart (4) | First | -- |
| Friday, July 29 |
| » Defeated Rangers (49-51), 8-6 | Memorial Stadium (31-18) | 57-40 | Won 3 |
| » W: Sammy Stewart (4-3) L: Dave Schmidt (2-2) | First | -- |
| Saturday, July 30 |
| » Defeated Rangers (49-52), 7-4 | Memorial Stadium (32-18) | 58-40 | Won 4 |
| » W: Scott McGregor (13-4) L: Mike Smithson (6-10) S: Tim Stoddard (4) | First | -- |
| Sunday, July 31 |
| » Defeated Rangers (49-53), 6-0 | Memorial Stadium (33-18) | 59-40 | Won 5 |
| » W: Mike Boddicker (7-5) L: Frank Tanana (4-4) | First | -- |
| Tuesday, August 2 |
| » Lost to Indians (43-60), 3-1 | Cleveland Stadium (1-2) | 59-41 | |
| » W: Bert Blyleven (7-9) L: Dennis Martinez (6-13) S: Bud Anderson (3) | First | -- |
| » Lost to Indians (44-60), 4-3 | Cleveland Stadium (1-3) | 59-42 | Lost 2 |
| » W: Tom Brennan (1-1) L: Allan Ramirez (4-2) S: Bud Anderson (4) | First | -- |
| Wednesday, August 3 |
| » Defeated Indians (44-61), 8-2 | Cleveland Stadium (2-3) | 60-42 | |
| » W: Storm Davis (10-4) L: Rick Sutcliffe (12-7) | First | -- |
| Thursday, August 4 |
| » Defeated Indians (44-62), 4-3 | Cleveland Stadium (3-3) | 61-42 | Won 2 |
| » W: Scott McGregor (14-4) L: Bud Anderson (0-3) S: Tippy Martinez (11) | First | -- |
| Friday, August 5 |
| » Defeated White Sox (56-50), 5-4 | Memorial Stadium (34-18) | 62-42 | Won 3 |
| » W: Mike Boddicker (8-5) L: Dennis Lamp (5-7) | First | -- |
| Saturday, August 6 |
| » Lost to White Sox (57-50), 6-4 | Memorial Stadium (34-19) | 62-43 | |
| » W: Floyd Bannister (9-9) L: Dennis Martinez (6-14) S: Salome Barojas (10) | First | -- |
| Sunday, August 7 |
| » Lost to White Sox (58-50), 4-3 | Memorial Stadium (34-20) | 62-44 | Lost 2 |
| » W: La Marr Hoyt (14-10) L: Mike Flanagan (6-1) S: Dennis Lamp (8) | First | -- |
| Monday, August 8 |
| » Lost to Indians (46-65), 9-4 | Memorial Stadium (34-21) | 62-45 | Lost 3 |
| » W: Rick Sutcliffe (13-7) L: Storm Davis (10-5) | First | -- |
| Tuesday, August 9 |
| » Lost to Indians (47-65), 4-3 | Memorial Stadium (34-22) | 62-46 | Lost 4 |
| » W: Neal Heaton (6-4) L: Scott McGregor (14-5) | First | -- |
| Wednesday, August 10 |
| » Lost to Indians (48-65), 4-3 | Memorial Stadium (34-23) | 62-47 | Lost 5 |
| » W: Lary Sorensen (6-9) L: Mike Boddicker (8-6) | First | -- |
| Thursday, August 11 |
| » Lost to White Sox (61-51), 9-3 | Comiskey Park I (1-2) | 62-48 | Lost 6 |
| » W: Floyd Bannister (10-9) L: Allan Ramirez (4-3) | Third | 1 out |
| Friday, August 12 |
| » Lost to White Sox (62-51), 2-1 | Comiskey Park I (1-3) | 62-49 | Lost 7 |
| » W: La Marr Hoyt (15-10) L: Mike Flanagan (6-2) | Third | 1 out |
| Saturday, August 13 |
| » Defeated White Sox (62-52), 5-2 | Comiskey Park I (2-3) | 63-49 | |
| » W: Sammy Stewart (5-3) L: Jerry Koosman (8-5) S: Tippy Martinez (12) | Second | 1 out |
| » Major-league debuts: Bill Swaggerty (Orioles) |
| Sunday, August 14 |
| » Defeated White Sox (62-53), 2-1 | Comiskey Park I (3-3) | 64-49 | Won 2 |
| » W: Scott McGregor (15-5) L: Richard Dotson (12-7) S: Tim Stoddard (5) | First | -- |
| Monday, August 15 |
| » Defeated Rangers (56-60), 6-4 | Arlington Stadium (3-1) | 65-49 | Won 3 |
| » W: Mike Boddicker (9-6) L: Mike Smithson (7-12) S: Tim Stoddard (6) | First | -- |
| Tuesday, August 16 |
| » Lost to Rangers (57-60), 2-0 | Arlington Stadium (3-2) | 65-50 | |
| » W: John Butcher (4-3) L: Allan Ramirez (4-4) | First | -- |
| Wednesday, August 17 |
| » Defeated Rangers (57-61), 4-2 | Arlington Stadium (4-2) | 66-50 | |
| » W: Mike Flanagan (7-2) L: Odell Jones (3-5) S: Tim Stoddard (7) | Second | 1½ out |
| Friday, August 19 |
| » Defeated Royals (58-59), 5-4 | Memorial Stadium (35-23) | 67-50 | Won 2 |
| » W: Sammy Stewart (6-3) L: Dan Quisenberry (5-2) | First | -- |
| » Defeated Royals (58-60), 3-1 | Memorial Stadium (36-23) | 68-50 | Won 3 |
| » W: Tippy Martinez (6-3) L: Eric Rasmussen (1-2) | First | -- |
| Saturday, August 20 |
| » Defeated Royals (58-61), 6-1 | Memorial Stadium (37-23) | 69-50 | Won 4 |
| » W: Mike Boddicker (10-6) L: Larry Gura (10-15) S: Tippy Martinez (13) | First | -- |
| Sunday, August 21 |
| » Lost to Royals (59-61), 8-3 | Memorial Stadium (37-24) | 69-51 | |
| » W: Bud Black (7-4) L: Jim Palmer (2-3) S: Dan Quisenberry (34) | First | -- |
| Monday, August 22 |
| » Major-league debuts: Carmelo Martinez (Cubs) |
| Tuesday, August 23 |
| » Lost to Blue Jays (70-55), 9-3 | Memorial Stadium (37-25) | 69-52 | Lost 2 |
| » W: Luis Leal (11-10) L: Mike Flanagan (7-3) | Second | 1½ out |
| Wednesday, August 24 |
| » Defeated Blue Jays (70-56), 7-4 | Memorial Stadium (38-25) | 70-52 | |
| » W: Tippy Martinez (7-3) L: Joey McLaughlin (7-3) | Second | 1½ out |
| Thursday, August 25 |
| » Defeated Blue Jays (70-57), 2-1 | Memorial Stadium (39-25) | 71-52 | Won 2 |
| » W: Tippy Martinez (8-3) L: Roy Lee Jackson (8-2) | Second | 1½ out |
| Friday, August 26 |
| » Defeated Twins (56-73), 9-0 | Memorial Stadium (40-25) | 72-52 | Won 3 |
| » W: Mike Boddicker (11-6) L: Ken Schrom (12-5) | First | -- |
| Saturday, August 27 |
| » Defeated Twins (56-74), 5-3 | Memorial Stadium (41-25) | 73-52 | Won 4 |
| » W: Jim Palmer (3-3) L: Albert Williams (9-12) S: Tim Stoddard (8) | First | -- |
| Sunday, August 28 |
| » Defeated Twins (56-75), 11-4 | Memorial Stadium (42-25) | 74-52 | Won 5 |
| » W: Mike Flanagan (8-3) L: Bobby Castillo (8-12) S: Sammy Stewart (5) | First | -- |
| Monday, August 29 |
| » Defeated Royals (64-65), 9-2 | Royals Stadium (3-2) | 75-52 | Won 6 |
| » W: Scott McGregor (16-5) L: Gaylord Perry (6-13) | First | -- |
| Tuesday, August 30 |
| » Defeated Royals (64-66), 12-4 | Royals Stadium (4-2) | 76-52 | Won 7 |
| » W: Storm Davis (11-5) L: Eric Rasmussen (2-3) | First | -- |
| Wednesday, August 31 |
| » Defeated Blue Jays (72-62), 10-2 | Exhibition Stadium (2-3) | 77-52 | Won 8 |
| » W: Mike Boddicker (12-6) L: Jim Gott (7-12) | First | -- |
| Thursday, September 1 |
| » Lost to Blue Jays (73-62), 5-3 | Exhibition Stadium (2-4) | 77-53 | |
| » W: Doyle Alexander (2-8) L: Jim Palmer (3-4) | First | -- |
| Friday, September 2 |
| » Defeated Twins (58-78), 1-0 | Hubert H. Humphrey Metrodome (3-1) | 78-53 | |
| » W: Mike Flanagan (9-3) L: Frank Viola (7-12) S: Tim Stoddard (9) | First | -- |
| Saturday, September 3 |
| » Defeated Twins (58-79), 13-0 | Hubert H. Humphrey Metrodome (4-1) | 79-53 | Won 2 |
| » W: Scott McGregor (17-5) L: Ken Schrom (12-7) | First | -- |
| » Major-league debuts: Tim Teufel (Twins) |
| Sunday, September 4 |
| » Defeated Twins (58-80), 9-6 | Hubert H. Humphrey Metrodome (5-1) | 80-53 | Won 3 |
| » W: Storm Davis (12-5) L: Ron Davis (3-7) S: Tippy Martinez (14) | First | -- |
| Monday, September 5 |
| » Lost to Red Sox (67-71), 2-0 | Memorial Stadium (42-26) | 80-54 | |
| » W: Bob Ojeda (8-7) L: Mike Boddicker (12-7) S: Bob Stanley (27) | First | -- |
| Tuesday, September 6 |
| » Defeated Red Sox (67-72), 8-1 | Memorial Stadium (43-26) | 81-54 | |
| » W: Jim Palmer (4-4) L: Dennis Eckersley (7-12) | First | -- |
| » Major-league debuts: Jackie Gutierrez and Al Nipper (Red Sox) |
| Wednesday, September 7 |
| » Defeated Red Sox (67-73), 5-2 | Memorial Stadium (44-26) | 82-54 | Won 2 |
| » W: Mike Flanagan (10-3) L: Oil Can Boyd (4-5) S: Tippy Martinez (15) | First | -- |
| Friday, September 9 |
| » Lost to Yankees (79-60), 5-3 | Yankee Stadium (0-4) | 82-55 | |
| » W: Ron Guidry (18-8) L: Scott McGregor (17-6) | First | -- |
| » Major-league debuts: Otis Nixon (Yankees) |
| Saturday, September 10 |
| » Defeated Yankees (79-61), 8-4 | Yankee Stadium (1-4) | 83-55 | |
| » W: Sammy Stewart (7-3) L: Shane Rawley (14-12) | First | -- |
| » Defeated Yankees (79-62), 3-1 | Yankee Stadium (2-4) | 84-55 | Won 2 |
| » W: Mike Boddicker (13-7) L: Rudy May (1-5) S: Tippy Martinez (16) | First | -- |
| Sunday, September 11 |
| » Defeated Yankees (79-63), 5-3 | Yankee Stadium (3-4) | 85-55 | Won 3 |
| » W: Mike Flanagan (11-3) L: Dave Righetti (14-7) S: Tippy Martinez (17) | First | -- |
| » Major-league debuts: Brian Dayett (Yankees) |
| Tuesday, September 13 |
| » Defeated Red Sox (69-75), 7-4 | Fenway Park (3-1) | 86-55 | Won 4 |
| » W: Sammy Stewart (8-3) L: Bob Stanley (8-10) | First | -- |
| » Defeated Red Sox (69-76), 7-1 | Fenway Park (4-1) | 87-55 | Won 5 |
| » W: Bill Swaggerty (1-0) L: Al Nipper (0-1) | First | -- |
| Wednesday, September 14 |
| » Defeated Red Sox (69-77), 5-0 | Fenway Park (5-1) | 88-55 | Won 6 |
| » W: Dennis Martinez (7-14) L: John Tudor (11-11) S: Sammy Stewart (6) | First | -- |
| Thursday, September 15 |
| » Lost to Red Sox (70-77), 7-1 | Fenway Park (5-2) | 88-56 | |
| » W: Bruce Hurst (12-10) L: Storm Davis (12-6) | First | -- |
| Friday, September 16 |
| » Defeated Brewers (79-68), 8-1 | Memorial Stadium (45-26) | 89-56 | |
| » W: Mike Boddicker (14-7) L: Tom Candiotti (4-2) | First | -- |
| » Major-league debuts: Dion James (Brewers) |
| Saturday, September 17 |
| » Defeated Brewers (79-69), 5-4 | Memorial Stadium (46-26) | 90-56 | Won 2 |
| » W: Mike Flanagan (12-3) L: Bob Gibson (2-3) S: Tippy Martinez (18) | First | -- |
| Sunday, September 18 |
| » Defeated Brewers (79-70), 10-9 | Memorial Stadium (47-26) | 91-56 | Won 3 |
| » W: Tippy Martinez (9-3) L: Pete Ladd (3-4) | First | -- |
| Monday, September 19 |
| » Defeated Brewers (79-71), 8-7 | Memorial Stadium (48-26) | 92-56 | Won 4 |
| » W: Tim Stoddard (4-3) L: Tom Tellmann (9-4) | First | -- |
| Tuesday, September 20 |
| » Lost to Tigers (86-64), 14-1 | Tiger Stadium (2-2) | 92-57 | |
| » W: Dan Petry (18-9) L: Dennis Martinez (7-15) | First | -- |
| Wednesday, September 21 |
| » Defeated Tigers (86-65), 6-0 | Tiger Stadium (3-2) | 93-57 | |
| » W: Mike Boddicker (15-7) L: Jack Morris (19-12) | First | -- |
| » Defeated Tigers (86-66), 7-3 | Tiger Stadium (4-2) | 94-57 | Won 2 |
| » W: Sammy Stewart (9-3) L: Dave Gumpert (0-2) | First | -- |
| Thursday, September 22 |
| » Lost to Tigers (87-66), 5-4 | Tiger Stadium (4-3) | 94-58 | |
| » W: Doug Bair (7-4) L: Sammy Stewart (9-4) | First | -- |
| Friday, September 23 |
| » Defeated Brewers (81-73), 4-2 | County Stadium (3-1) | 95-58 | |
| » W: Scott McGregor (18-6) L: Bob Gibson (2-4) S: Sammy Stewart (7) | First | -- |
| Saturday, September 24 |
| » Lost to Brewers (82-73), 5-2 | County Stadium (3-2) | 95-59 | |
| » W: Jaime Cocanower (1-0) L: Dennis Martinez (7-16) S: Pete Ladd (23) | First | -- |
| Sunday, September 25 |
| » Defeated Brewers (82-74), 5-1 | County Stadium (4-2) | 96-59 | |
| » W: Storm Davis (13-6) L: Chuck Porter (6-9) S: Tippy Martinez (19) | First | -- |
| Tuesday, September 27 |
| » Lost to Tigers (90-67), 9-2 | Memorial Stadium (48-27) | 96-60 | |
| » W: Jack Morris (20-12) L: Scott McGregor (18-7) | First | -- |
| Wednesday, September 28 |
| » Lost to Tigers (91-67), 9-5 | Memorial Stadium (48-28) | 96-61 | Lost 2 |
| » W: Dan Petry (19-10) L: Mike Boddicker (15-8) | First | -- |
| Thursday, September 29 |
| » Lost to Tigers (92-67), 9-4 | Memorial Stadium (48-29) | 96-62 | Lost 3 |
| » W: Milt Wilcox (11-10) L: Mike Flanagan (12-4) | First | -- |
| Friday, September 30 |
| » Lost to Yankees (90-69), 6-4 | Memorial Stadium (48-30) | 96-63 | Lost 4 |
| » W: John Montefusco (14-4) L: Storm Davis (13-7) S: George Frazier (8) | First | -- |
| » Defeated Yankees (90-70), 3-2 | Memorial Stadium (49-30) | 97-63 | |
| » W: Jim Palmer (5-4) L: Jay Howell (1-5) S: Tippy Martinez (20) | First | -- |
| Saturday, October 1 |
| » Lost to Yankees (91-70), 5-4 | Memorial Stadium (49-31) | 97-64 | |
| » W: Rich Gossage (13-5) L: Bill Swaggerty (1-1) | First | -- |
| Sunday, October 2 |
| » Defeated Yankees (91-71), 2-0 | Memorial Stadium (50-31) | 98-64 | |
| » W: Mike Boddicker (16-8) L: Shane Rawley (14-14) S: Tippy Martinez (21) | First | -- |
Game information provided by Retrosheet (www.retrosheet.org) |