| Tuesday, April 5 |
| » Defeated Yankees (0-1), 5-4 | Kingdome (1-0) | 1-0 | |
| » W: Bryan Clark (1-0) L: Roger Erickson (0-1) S: Bill Caudill (1) | Second | ½ out |
| Wednesday, April 6 |
| » Defeated Yankees (0-2), 6-2 | Kingdome (2-0) | 2-0 | Won 2 |
| » W: Matt Young (1-0) L: Bob Shirley (0-1) S: Mike Stanton (1) | Second | ½ out |
| » Major-league debuts: Matt Young (Mariners) |
| Thursday, April 7 |
| » Lost to Yankees (1-2), 8-1 | Kingdome (2-1) | 2-1 | |
| » W: Dave Righetti (1-0) L: Bob Stoddard (0-1) S: George Frazier (1) | Second | 1 out |
| » Major-league debuts: Rod Allen (Mariners) |
| Friday, April 8 |
| » Lost to Twins (2-2), 5-4 | Kingdome (2-2) | 2-2 | Lost 2 |
| » W: Rick Lysander (1-1) L: Bill Caudill (0-1) S: Len Whitehouse (1) | Third | 1 out |
| Saturday, April 9 |
| » Defeated Twins (2-3), 3-2 | Kingdome (3-2) | 3-2 | |
| » W: Roy Thomas (1-0) L: Bryan Oelkers (0-1) S: Bill Caudill (2) | Third | 1 out |
| » Major-league debuts: Bryan Oelkers and Tack Wilson (Twins) |
| Sunday, April 10 |
| » Lost to Twins (3-3), 6-3 | Kingdome (3-3) | 3-3 | |
| » W: Brad Havens (1-1) L: Gaylord Perry (0-1) S: Ron Davis (2) | Third | 2 out |
| Monday, April 11 |
| » Lost to Angels (4-3), 6-1 | Anaheim Stadium (0-1) | 3-4 | Lost 2 |
| » W: Tommy John (2-0) L: Matt Young (1-1) | Fifth | 2½ out |
| Tuesday, April 12 |
| » Defeated Angels (4-4), 8-1 | Anaheim Stadium (1-1) | 4-4 | |
| » W: Bob Stoddard (1-1) L: Mike Witt (0-2) | Fourth | 2½ out |
| Wednesday, April 13 |
| » Lost to Angels (5-4), 6-1 | Anaheim Stadium (1-2) | 4-5 | |
| » W: Geoff Zahn (1-1) L: Mike Moore (0-1) | Fifth | 2½ out |
| Thursday, April 14 |
| » Lost to Athletics (6-3), 5-3 | Kingdome (3-4) | 4-6 | Lost 2 |
| » W: Chris Codiroli (1-0) L: Edwin Nunez (0-1) S: Dave Beard (2) | Sixth | 3 out |
| Friday, April 15 |
| » Defeated Athletics (6-4), 5-1 | Kingdome (4-4) | 5-6 | |
| » W: Gaylord Perry (1-1) L: Matt Keough (0-2) | Fourth | 2 out |
| Saturday, April 16 |
| » Lost to Athletics (7-4), 5-2 | Kingdome (4-5) | 5-7 | |
| » W: Bill Krueger (2-0) L: Matt Young (1-2) S: Dave Beard (3) | Fifth | 2½ out |
| Sunday, April 17 |
| » Lost to Athletics (8-4), 7-4 | Kingdome (4-6) | 5-8 | Lost 2 |
| » W: Mike Norris (2-0) L: Bob Stoddard (1-2) S: Tom Burgmeier (1) | Sixth | 3½ out |
| Monday, April 18 |
| » Lost to Twins (5-7), 8-5 | Hubert H. Humphrey Metrodome (0-1) | 5-9 | Lost 3 |
| » W: Jack O'Connor (1-0) L: Mike Moore (0-2) S: Pete Filson (1) | Seventh | 4½ out |
| Tuesday, April 19 |
| » Lost to Twins (6-7), 6-2 | Hubert H. Humphrey Metrodome (0-2) | 5-10 | Lost 4 |
| » W: Len Whitehouse (2-1) L: Edwin Nunez (0-2) | Seventh | 5 out |
| Wednesday, April 20 |
| » Lost to Twins (7-7), 11-2 | Hubert H. Humphrey Metrodome (0-3) | 5-11 | Lost 5 |
| » W: Bobby Castillo (1-0) L: Gaylord Perry (1-2) | Seventh | 5½ out |
| Thursday, April 21 |
| » Defeated Twins (7-8), 2-0 | Hubert H. Humphrey Metrodome (1-3) | 6-11 | |
| » W: Matt Young (2-2) L: Bryan Oelkers (0-3) S: Bill Caudill (3) | Sixth | 4 out |
| Friday, April 22 |
| » Lost to Tigers (6-7), 4-0 | Tiger Stadium (0-1) | 6-12 | |
| » W: Milt Wilcox (2-1) L: Bob Stoddard (1-3) | Seventh | 4½ out |
| Saturday, April 23 |
| » Lost to Tigers (7-7), 4-0 | Tiger Stadium (0-2) | 6-13 | Lost 2 |
| » W: Dan Petry (3-0) L: Mike Moore (0-3) | Sixth | 5 out |
| Sunday, April 24 |
| » Lost to Tigers (8-7), 4-2 | Tiger Stadium (0-3) | 6-14 | Lost 3 |
| » W: Jack Morris (2-2) L: Edwin Nunez (0-3) S: Aurelio Lopez (1) | Sixth | 5½ out |
| Tuesday, April 26 |
| » Defeated Red Sox (8-8), 7-6 | Kingdome (5-6) | 7-14 | |
| » W: Gaylord Perry (2-2) L: Mike Brown (1-2) S: Bill Caudill (4) | Sixth | 5½ out |
| Wednesday, April 27 |
| » Lost to Red Sox (9-8), 2-1 | Kingdome (5-7) | 7-15 | |
| » W: Dennis Eckersley (2-1) L: Matt Young (2-3) S: Bob Stanley (5) | Sixth | 6½ out |
| Friday, April 29 |
| » Lost to Orioles (11-8), 9-1 | Kingdome (5-8) | 7-16 | Lost 2 |
| » W: Scott McGregor (3-0) L: Jim Beattie (0-1) | Sixth | 6½ out |
| Saturday, April 30 |
| » Defeated Orioles (11-9), 6-2 | Kingdome (6-8) | 8-16 | |
| » W: Bob Stoddard (2-3) L: Dennis Martinez (1-5) S: Ed Vande Berg (1) | Seventh | 6½ out |
| Sunday, May 1 |
| » Lost to Orioles (12-9), 8-2 | Kingdome (6-9) | 8-17 | |
| » W: Storm Davis (1-0) L: Gaylord Perry (2-3) S: Tippy Martinez (2) | Sixth | 6½ out |
| Tuesday, May 3 |
| » Lost to Tigers (9-11), 2-1 | Kingdome (6-10) | 8-18 | Lost 2 |
| » W: Aurelio Lopez (1-0) L: Bill Caudill (0-2) | Sixth | 7 out |
| Wednesday, May 4 |
| » Defeated Tigers (9-12), 5-1 | Kingdome (7-10) | 9-18 | |
| » W: Jim Beattie (1-1) L: Jack Morris (2-4) S: Roy Thomas (1) | Seventh | 6½ out |
| Friday, May 6 |
| » Lost to Red Sox (14-9), 6-4 | Fenway Park (0-1) | 9-19 | |
| » W: Luis Aponte (3-0) L: Ed Vande Berg (0-1) | Seventh | 7½ out |
| Saturday, May 7 |
| » Lost to Red Sox (15-9), 8-0 | Fenway Park (0-2) | 9-20 | Lost 2 |
| » W: Mike Brown (2-2) L: Bob Stoddard (2-4) | Seventh | 8½ out |
| Sunday, May 8 |
| » Defeated Red Sox (15-10), 4-2 | Fenway Park (1-2) | 10-20 | |
| » W: Matt Young (3-3) L: Doug Bird (0-1) S: Bill Caudill (5) | Sixth | 7½ out |
| Monday, May 9 |
| » Defeated Orioles (15-12), 6-4 | Memorial Stadium (1-0) | 11-20 | Won 2 |
| » W: Jim Beattie (2-1) L: Scott McGregor (3-2) S: Bill Caudill (6) | Sixth | 6½ out |
| Tuesday, May 10 |
| » Lost to Orioles (16-12), 13-2 | Memorial Stadium (1-1) | 11-21 | |
| » W: Dennis Martinez (3-5) L: Edwin Nunez (0-4) | Seventh | 7½ out |
| Wednesday, May 11 |
| » Lost to Orioles (17-12), 1-0 | Memorial Stadium (1-2) | 11-22 | Lost 2 |
| » W: Mike Flanagan (6-0) L: Gaylord Perry (2-4) | Seventh | 8½ out |
| Friday, May 13 |
| » Lost to Athletics (16-15), 9-2 | Oakland-Alameda County Stadium (0-1) | 11-23 | Lost 3 |
| » W: Bill Krueger (4-3) L: Bob Stoddard (2-5) | Seventh | 8½ out |
| Saturday, May 14 |
| » Defeated Athletics (16-16), 4-1 | Oakland-Alameda County Stadium (1-1) | 12-23 | |
| » W: Matt Young (4-3) L: Rick Langford (0-4) S: Bill Caudill (7) | Seventh | 7½ out |
| Sunday, May 15 |
| » Lost to Athletics (17-16), 3-0 | Oakland-Alameda County Stadium (1-2) | 12-24 | |
| » W: Tom Underwood (2-1) L: Jim Beattie (2-2) S: Steve McCatty (3) | Seventh | 7½ out |
| Tuesday, May 17 |
| » Lost to Angels (19-15), 3-1 | Kingdome (7-11) | 12-25 | Lost 2 |
| » W: Bruce Kison (5-1) L: Gaylord Perry (2-5) | Sixth | 8½ out |
| Wednesday, May 18 |
| » Defeated Angels (19-16), 2-1 | Kingdome (8-11) | 13-25 | |
| » W: Bob Stoddard (3-5) L: Geoff Zahn (3-3) S: Bill Caudill (8) | Seventh | 8½ out |
| Thursday, May 19 |
| » Defeated Angels (19-17), 1-0 | Kingdome (9-11) | 14-25 | Won 2 |
| » W: Matt Young (5-3) L: Ken Forsch (3-3) | Sixth | 7½ out |
| Friday, May 20 |
| » Lost to Brewers (19-15), 4-3 | Kingdome (9-12) | 14-26 | |
| » W: Tom Tellmann (3-0) L: Bryan Clark (1-1) | Sixth | 8½ out |
| Saturday, May 21 |
| » Defeated Brewers (19-16), 5-4 | Kingdome (10-12) | 15-26 | |
| » W: Bryan Clark (2-1) L: Bob McClure (1-7) | Sixth | 7½ out |
| Sunday, May 22 |
| » Lost to Brewers (20-16), 6-0 | Kingdome (10-13) | 15-27 | |
| » W: Mike Caldwell (4-4) L: Gaylord Perry (2-6) | Sixth | 7½ out |
| Monday, May 23 |
| » Defeated Indians (18-21), 3-2 | Kingdome (11-13) | 16-27 | |
| » W: Bob Stoddard (4-5) L: Rick Sutcliffe (5-2) S: Bill Caudill (9) | Sixth | 7½ out |
| Tuesday, May 24 |
| » Lost to Indians (19-21), 6-4 | Kingdome (11-14) | 16-28 | |
| » W: Neal Heaton (2-1) L: Bill Caudill (0-3) | Seventh | 8½ out |
| Wednesday, May 25 |
| » Defeated Indians (19-22), 2-1 | Kingdome (12-14) | 17-28 | |
| » W: Jim Beattie (3-2) L: Juan Eichelberger (1-3) S: Mike Stanton (2) | Seventh | 8½ out |
| Friday, May 27 |
| » Defeated Brewers (21-19), 7-5 | County Stadium (1-0) | 18-28 | Won 2 |
| » W: Gaylord Perry (3-6) L: Tom Tellmann (3-1) S: Bill Caudill (10) | Sixth | 8½ out |
| Saturday, May 28 |
| » Defeated Brewers (21-20), 4-3 | County Stadium (2-0) | 19-28 | Won 3 |
| » W: Ed Vande Berg (1-1) L: Jim Slaton (5-2) | Sixth | 8½ out |
| Sunday, May 29 |
| » Defeated Brewers (21-21), 6-4 | County Stadium (3-0) | 20-28 | Won 4 |
| » W: Matt Young (6-3) L: Don Sutton (4-2) S: Bill Caudill (11) | Sixth | 8½ out |
| Monday, May 30 |
| » Lost to Brewers (22-21), 6-3 | County Stadium (3-1) | 20-29 | |
| » W: Jerry Augustine (2-0) L: Jim Beattie (3-3) S: Tom Tellmann (4) | Seventh | 8½ out |
| Tuesday, May 31 |
| » Lost to Indians (21-25), 5-2 | Cleveland Stadium (0-1) | 20-30 | Lost 2 |
| » W: Juan Eichelberger (2-3) L: Gene Nelson (0-1) S: Dan Spillner (6) | Seventh | 8½ out |
| Wednesday, June 1 |
| » Lost to Indians (22-25), 5-2 | Cleveland Stadium (0-2) | 20-31 | Lost 3 |
| » W: Neal Heaton (4-1) L: Gaylord Perry (3-7) | Seventh | 8½ out |
| Thursday, June 2 |
| » Lost to Indians (23-25), 3-1 | Cleveland Stadium (0-3) | 20-32 | Lost 4 |
| » W: Rick Sutcliffe (6-2) L: Bob Stoddard (4-6) | Seventh | 9½ out |
| Friday, June 3 |
| » Defeated Yankees (26-23), 5-0 | Yankee Stadium (1-0) | 21-32 | |
| » W: Matt Young (7-3) L: Jay Howell (0-2) | Sixth | 9½ out |
| Saturday, June 4 |
| » Defeated Yankees (26-24), 5-4 | Yankee Stadium (2-0) | 22-32 | Won 2 |
| » W: Jim Beattie (4-3) L: Bob Shirley (2-4) S: Bill Caudill (12) | Seventh | 9½ out |
| Sunday, June 5 |
| » Defeated Yankees (26-25), 8-7 | Yankee Stadium (3-0) | 23-32 | Won 3 |
| » W: Bryan Clark (3-1) L: Shane Rawley (5-5) S: Bill Caudill (13) | Seventh | 8½ out |
| Monday, June 6 |
| » Lost to Yankees (27-25), 6-2 | Yankee Stadium (3-1) | 23-33 | |
| » W: Ron Guidry (8-3) L: Ed Vande Berg (1-2) | Seventh | 8½ out |
| Tuesday, June 7 |
| » Lost to Rangers (25-26), 10-0 | Kingdome (12-15) | 23-34 | Lost 2 |
| » W: Rick Honeycutt (8-3) L: Bob Stoddard (4-7) | Seventh | 8½ out |
| Wednesday, June 8 |
| » Lost to Rangers (26-26), 1-0 | Kingdome (12-16) | 23-35 | Lost 3 |
| » W: Mike Smithson (4-4) L: Matt Young (7-4) S: Odell Jones (8) | Seventh | 9½ out |
| Thursday, June 9 |
| » Defeated Rangers (26-27), 3-2 | Kingdome (13-16) | 24-35 | |
| » W: Bill Caudill (1-3) L: Charlie Hough (3-6) | Sixth | 9½ out |
| Friday, June 10 |
| » Lost to Royals (27-24), 2-0 | Kingdome (13-17) | 24-36 | |
| » W: Paul Splittorff (4-1) L: Bob Stoddard (4-8) S: Mike Armstrong (1) | Sixth | 10½ out |
| Saturday, June 11 |
| » Lost to Royals (28-24), 4-1 | Kingdome (13-18) | 24-37 | Lost 2 |
| » W: Bud Black (3-0) L: Gaylord Perry (3-8) S: Dan Quisenberry (16) | Sixth | 10½ out |
| Sunday, June 12 |
| » Defeated Royals (28-25), 8-1 | Kingdome (14-18) | 25-37 | |
| » W: Glenn Abbott (1-0) L: Larry Gura (5-8) | Sixth | 9½ out |
| Monday, June 13 |
| » Lost to Rangers (30-27), 5-2 | Arlington Stadium (0-1) | 25-38 | |
| » W: Mike Smithson (5-4) L: Matt Young (7-5) S: John Butcher (3) | Sixth | 10½ out |
| Tuesday, June 14 |
| » Lost to Rangers (31-27), 7-1 | Arlington Stadium (0-2) | 25-39 | Lost 2 |
| » W: Charlie Hough (4-6) L: Jim Beattie (4-4) | Seventh | 11 out |
| Wednesday, June 15 |
| » Defeated Rangers (31-28), 6-4 | Arlington Stadium (1-2) | 26-39 | |
| » W: Ed Vande Berg (2-2) L: Odell Jones (2-3) | Seventh | 10 out |
| Friday, June 17 |
| » Lost to Royals (29-28), 3-1 | Royals Stadium (0-1) | 26-40 | |
| » W: Larry Gura (6-8) L: Gaylord Perry (3-9) S: Dan Quisenberry (17) | Seventh | 10 out |
| Saturday, June 18 |
| » Lost to Royals (30-28), 6-5 | Royals Stadium (0-2) | 26-41 | Lost 2 |
| » W: Dan Quisenberry (3-1) L: Bill Caudill (1-4) | Seventh | 11 out |
| Sunday, June 19 |
| » Lost to Royals (31-28), 4-2 | Royals Stadium (0-3) | 26-42 | Lost 3 |
| » W: Bill Castro (2-0) L: Matt Young (7-6) S: Mike Armstrong (2) | Seventh | 11 out |
| Monday, June 20 |
| » Lost to White Sox (31-33), 7-3 | Comiskey Park I (0-1) | 26-43 | Lost 4 |
| » W: La Marr Hoyt (8-7) L: Jim Beattie (4-5) | Seventh | 12 out |
| Tuesday, June 21 |
| » Lost to White Sox (32-33), 4-2 | Comiskey Park I (0-2) | 26-44 | Lost 5 |
| » W: Richard Dotson (6-5) L: Bob Stoddard (4-9) S: Juan Agosto (3) | Seventh | 12 out |
| Wednesday, June 22 |
| » Lost to White Sox (33-33), 6-3 | Comiskey Park I (0-3) | 26-45 | Lost 6 |
| » W: Jerry Koosman (6-1) L: Gaylord Perry (3-10) S: Salome Barojas (5) | Seventh | 12 out |
| Thursday, June 23 |
| » Lost to Blue Jays (38-29), 5-4 | Kingdome (14-19) | 26-46 | Lost 7 |
| » W: Jim Clancy (6-5) L: Mike Stanton (0-1) S: Joey McLaughlin (7) | Seventh | 13 out |
| Friday, June 24 |
| » Lost to Blue Jays (39-29), 4-2 | Kingdome (14-20) | 26-47 | Lost 8 |
| » W: Luis Leal (7-6) L: Matt Young (7-7) | Seventh | 13½ out |
| Saturday, June 25 |
| » Defeated Blue Jays (39-30), 5-2 | Kingdome (15-20) | 27-47 | |
| » Manager: Del Crandall |
| » W: Jim Beattie (5-5) L: Jim Gott (5-6) S: Bill Caudill (14) | Seventh | 13½ out |
| » Major-league debuts: Spike Owen (Mariners) |
| Sunday, June 26 |
| » Lost to Blue Jays (40-30), 19-7 | Kingdome (15-21) | 27-48 | |
| » W: Jim Acker (2-0) L: Bob Stoddard (4-10) | Seventh | 14½ out |
| Monday, June 27 |
| » Lost to White Sox (37-34), 7-4 | Kingdome (15-22) | 27-49 | Lost 2 |
| » W: Dennis Lamp (4-5) L: Bryan Clark (3-2) S: Juan Agosto (5) | Sixth | 14½ out |
| Tuesday, June 28 |
| » Defeated White Sox (37-35), 6-2 | Kingdome (16-22) | 28-49 | |
| » W: Glenn Abbott (2-0) L: Floyd Bannister (3-9) S: Bill Caudill (15) | Seventh | 14½ out |
| Wednesday, June 29 |
| » Lost to White Sox (38-35), 5-3 | Kingdome (16-23) | 28-50 | |
| » W: Britt Burns (4-5) L: Matt Young (7-8) S: Salome Barojas (7) | Sixth | 14½ out |
| Friday, July 1 |
| » Defeated Blue Jays (42-32), 11-2 | Exhibition Stadium (1-0) | 29-50 | |
| » W: Jim Beattie (6-5) L: Jim Gott (5-7) | Seventh | 15 out |
| Saturday, July 2 |
| » Lost to Blue Jays (43-32), 7-6 | Exhibition Stadium (1-1) | 29-51 | |
| » W: Roy Lee Jackson (6-1) L: Bill Caudill (1-5) | Seventh | 16 out |
| Sunday, July 3 |
| » Defeated Blue Jays (43-33), 4-1 | Exhibition Stadium (2-1) | 30-51 | |
| » W: Glenn Abbott (3-0) L: Dave Stieb (10-7) | Seventh | 16 out |
| Friday, July 8 |
| » Defeated Orioles (42-35), 3-0 | Memorial Stadium (2-2) | 31-51 | Won 2 |
| » W: Jim Beattie (7-5) L: Storm Davis (6-4) | Seventh | 14½ out |
| Saturday, July 9 |
| » Defeated Orioles (42-36), 3-2 | Memorial Stadium (3-2) | 32-51 | Won 3 |
| » W: Bill Caudill (2-5) L: Sammy Stewart (2-3) | Seventh | 13½ out |
| Sunday, July 10 |
| » Lost to Orioles (43-36), 2-0 | Memorial Stadium (3-3) | 32-52 | |
| » W: Mike Boddicker (5-4) L: Matt Young (7-9) | Sixth | 13½ out |
| Monday, July 11 |
| » Lost to Red Sox (41-40), 6-5 | Fenway Park (1-3) | 32-53 | Lost 2 |
| » W: Luis Aponte (4-3) L: Mike Stanton (0-2) | Seventh | 14½ out |
| Tuesday, July 12 |
| » Defeated Red Sox (41-41), 3-2 | Fenway Park (2-3) | 33-53 | |
| » W: Bryan Clark (4-2) L: Mike Brown (5-5) S: Bill Caudill (16) | Seventh | 13½ out |
| Wednesday, July 13 |
| » Defeated Red Sox (41-42), 6-4 | Fenway Park (3-3) | 34-53 | Won 2 |
| » W: Jim Beattie (8-5) L: Dennis Eckersley (5-7) S: Bill Caudill (17) | Seventh | 12½ out |
| Thursday, July 14 |
| » Lost to Tigers (47-36), 4-2 | Kingdome (16-24) | 34-54 | |
| » W: Jack Morris (9-8) L: Glenn Abbott (3-1) S: Doug Bair (5) | Seventh | 13½ out |
| Friday, July 15 |
| » Defeated Tigers (47-37), 7-2 | Kingdome (17-24) | 35-54 | |
| » W: Matt Young (8-9) L: Juan Berenguer (4-2) | Seventh | 12½ out |
| Saturday, July 16 |
| » Defeated Tigers (47-38), 1-0 | Kingdome (18-24) | 36-54 | Won 2 |
| » W: Mike Moore (1-3) L: Aurelio Lopez (5-4) | Seventh | 11½ out |
| Sunday, July 17 |
| » Lost to Tigers (48-38), 8-1 | Kingdome (18-25) | 36-55 | |
| » W: Doug Bair (4-1) L: Bill Caudill (2-6) | Seventh | 11½ out |
| Monday, July 18 |
| » Lost to Orioles (50-37), 9-4 | Kingdome (18-26) | 36-56 | Lost 2 |
| » W: Storm Davis (8-4) L: Jim Beattie (8-6) | Seventh | 12 out |
| Tuesday, July 19 |
| » Lost to Orioles (51-37), 8-1 | Kingdome (18-27) | 36-57 | Lost 3 |
| » W: Scott McGregor (11-4) L: Glenn Abbott (3-2) | Seventh | 12 out |
| Wednesday, July 20 |
| » Lost to Orioles (52-37), 4-2 | Kingdome (18-28) | 36-58 | Lost 4 |
| » W: Sammy Stewart (3-3) L: Matt Young (8-10) S: Tim Stoddard (3) | Seventh | 13 out |
| Thursday, July 21 |
| » Lost to Red Sox (46-45), 14-13 | Kingdome (18-29) | 36-59 | Lost 5 |
| » W: John Henry Johnson (2-1) L: Ed Vande Berg (2-3) S: Bob Stanley (19) | Seventh | 13 out |
| Friday, July 22 |
| » Lost to Red Sox (47-45), 5-4 | Kingdome (18-30) | 36-60 | Lost 6 |
| » W: Mike Brown (6-5) L: Ed Vande Berg (2-4) S: John Henry Johnson (1) | Seventh | 14 out |
| Saturday, July 23 |
| » Defeated Red Sox (47-46), 5-0 | Kingdome (19-30) | 37-60 | |
| » W: Bob Stoddard (5-10) L: Dennis Eckersley (6-8) | Seventh | 13 out |
| » Major-league debuts: Al Chambers (Mariners) |
| Sunday, July 24 |
| » Lost to Red Sox (48-46), 6-0 | Kingdome (19-31) | 37-61 | |
| » W: John Tudor (8-6) L: Glenn Abbott (3-3) | Seventh | 13 out |
| Tuesday, July 26 |
| » Lost to Tigers (55-40), 8-3 | Tiger Stadium (0-4) | 37-62 | Lost 2 |
| » W: Dave Rozema (7-1) L: Matt Young (8-11) S: Juan Berenguer (1) | Seventh | 14 out |
| Wednesday, July 27 |
| » Defeated Tigers (55-41), 5-3 | Tiger Stadium (1-4) | 38-62 | |
| » W: Mike Moore (2-3) L: Doug Bair (4-3) S: Bill Caudill (18) | Seventh | 14 out |
| Thursday, July 28 |
| » Lost to Tigers (56-41), 6-1 | Tiger Stadium (1-5) | 38-63 | |
| » W: Dan Petry (11-6) L: Bryan Clark (4-3) | Seventh | 14½ out |
| Friday, July 29 |
| » Lost to Twins (43-59), 4-3 | Hubert H. Humphrey Metrodome (1-4) | 38-64 | Lost 2 |
| » W: Bobby Castillo (7-8) L: Bill Caudill (2-7) S: Ron Davis (19) | Seventh | 15½ out |
| Saturday, July 30 |
| » Defeated Twins (43-60), 7-3 | Hubert H. Humphrey Metrodome (2-4) | 39-64 | |
| » W: Glenn Abbott (4-3) L: Frank Viola (5-8) S: Mike Stanton (3) | Seventh | 15½ out |
| Sunday, July 31 |
| » Defeated Twins (43-61), 3-2 | Hubert H. Humphrey Metrodome (3-4) | 40-64 | Won 2 |
| » W: Roy Thomas (2-0) L: Ron Davis (3-5) S: Bill Caudill (19) | Seventh | 14½ out |
| Future Mariner Rene Rivera is born in Bayamon, P.R. |
| Monday, August 1 |
| » Lost to Athletics (49-57), 4-3 | Kingdome (19-32) | 40-65 | |
| » W: Tom Underwood (7-5) L: Mike Stanton (0-3) S: Dave Beard (5) | Seventh | 15½ out |
| Tuesday, August 2 |
| » Defeated Athletics (49-58), 15-12 | Kingdome (20-32) | 41-65 | |
| » W: Roy Thomas (3-0) L: Chris Codiroli (7-8) S: Ed Vande Berg (2) | Seventh | 15½ out |
| Wednesday, August 3 |
| » Lost to Athletics (50-58), 6-1 | Kingdome (20-33) | 41-66 | |
| » W: Tim Conroy (4-4) L: Jim Beattie (8-7) | Seventh | 15½ out |
| Thursday, August 4 |
| » Defeated Angels (52-56), 11-5 | Kingdome (21-33) | 42-66 | |
| » W: Bryan Clark (5-3) L: John Curtis (1-1) S: Ed Vande Berg (3) | Seventh | 15½ out |
| Friday, August 5 |
| » Defeated Angels (52-57), 3-1 | Kingdome (22-33) | 43-66 | Won 2 |
| » W: Bob Stoddard (6-10) L: Geoff Zahn (8-6) S: Bill Caudill (20) | Seventh | 14½ out |
| Saturday, August 6 |
| » Defeated Angels (52-58), 2-1 | Kingdome (23-33) | 44-66 | Won 3 |
| » W: Mike Moore (3-3) L: Mike Witt (5-9) S: Bill Caudill (21) | Seventh | 14½ out |
| Sunday, August 7 |
| » Lost to Angels (53-58), 4-3 | Kingdome (23-34) | 44-67 | |
| » W: Ken Forsch (10-7) L: Bryan Clark (5-4) S: Bruce Kison (1) | Seventh | 15½ out |
| Monday, August 8 |
| » Lost to Athletics (54-59), 2-1 | Oakland-Alameda County Stadium (1-3) | 44-68 | Lost 2 |
| » W: Tim Conroy (5-4) L: Jim Beattie (8-8) S: Dave Beard (7) | Seventh | 16 out |
| Tuesday, August 9 |
| » Lost to Athletics (55-59), 7-6 | Oakland-Alameda County Stadium (1-4) | 44-69 | Lost 3 |
| » W: Tom Underwood (8-5) L: Bob Stoddard (6-11) S: Dave Beard (8) | Seventh | 17 out |
| Wednesday, August 10 |
| » Defeated Athletics (55-60), 7-5 | Oakland-Alameda County Stadium (2-4) | 45-69 | |
| » W: Matt Young (9-11) L: Gorman Heimueller (1-3) S: Ed Vande Berg (4) | Seventh | 16½ out |
| Friday, August 12 |
| » Defeated Angels (54-61), 7-6 | Anaheim Stadium (2-2) | 46-69 | Won 2 |
| » W: Mike Stanton (1-3) L: Luis Sanchez (8-6) S: Bill Caudill (22) | Seventh | 17 out |
| Saturday, August 13 |
| » Lost to Angels (55-61), 10-5 | Anaheim Stadium (2-3) | 46-70 | |
| » W: Ken Forsch (11-7) L: Bob Stoddard (6-12) S: John Curtis (2) | Seventh | 17 out |
| Sunday, August 14 |
| » Lost to Angels (56-61), 7-2 | Anaheim Stadium (2-4) | 46-71 | Lost 2 |
| » W: Tommy John (9-9) L: Jim Beattie (8-9) | Seventh | 17 out |
| Monday, August 15 |
| » Lost to Twins (50-70), 7-4 | Kingdome (23-35) | 46-72 | Lost 3 |
| » W: Frank Viola (6-10) L: Bryan Clark (5-5) S: Ron Davis (21) | Seventh | 18 out |
| Tuesday, August 16 |
| » Lost to Twins (51-70), 5-1 | Kingdome (23-36) | 46-73 | Lost 4 |
| » W: Ken Schrom (11-4) L: Matt Young (9-12) S: Ron Davis (22) | Seventh | 19 out |
| Wednesday, August 17 |
| » Lost to Twins (52-70), 7-4 | Kingdome (23-37) | 46-74 | Lost 5 |
| » W: Albert Williams (8-11) L: Mike Moore (3-4) S: Mike Walters (1) | Seventh | 20 out |
| Friday, August 19 |
| » Lost to Indians (51-70), 6-5 | Cleveland Stadium (0-4) | 46-75 | Lost 6 |
| » W: Neal Heaton (8-4) L: Karl Best (0-1) S: Jamie Easterly (2) | Seventh | 21½ out |
| » Major-league debuts: Karl Best (Mariners) |
| Saturday, August 20 |
| » Lost to Indians (52-70), 3-2 | Cleveland Stadium (0-5) | 46-76 | Lost 7 |
| » W: Jamie Easterly (3-1) L: Jim Beattie (8-10) | Seventh | 21½ out |
| Sunday, August 21 |
| » Defeated Indians (52-71), 7-2 | Cleveland Stadium (1-5) | 47-76 | |
| » W: Glenn Abbott (5-3) L: Mike Jeffcoat (0-1) S: Mike Stanton (4) | Seventh | 21½ out |
| » Major-league debuts: Mike Jeffcoat (Indians) |
| Monday, August 22 |
| » Lost to Brewers (71-52), 3-2 | County Stadium (3-2) | 47-77 | |
| » W: Chuck Porter (6-5) L: Bob Stoddard (6-13) | Seventh | 22½ out |
| Tuesday, August 23 |
| » Defeated Brewers (71-53), 5-0 | County Stadium (4-2) | 48-77 | |
| » W: Mike Moore (4-4) L: Mike Caldwell (9-9) | Seventh | 21½ out |
| Wednesday, August 24 |
| » Lost to Yankees (68-56), 6-3 | Yankee Stadium (3-2) | 48-78 | |
| » W: Ron Guidry (15-8) L: Bryan Clark (5-6) | Seventh | 22½ out |
| Thursday, August 25 |
| » Lost to Yankees (69-56), 7-4 | Yankee Stadium (3-3) | 48-79 | Lost 2 |
| » W: Shane Rawley (13-10) L: Jim Beattie (8-11) | Sixth | 22½ out |
| Friday, August 26 |
| » Lost to Indians (55-74), 4-1 | Kingdome (23-38) | 48-80 | Lost 3 |
| » W: Rick Sutcliffe (14-9) L: Bob Stoddard (6-14) | Sixth | 22½ out |
| Saturday, August 27 |
| » Defeated Indians (55-75), 6-3 | Kingdome (24-38) | 49-80 | |
| » W: Matt Young (10-12) L: Juan Eichelberger (4-11) S: Mike Stanton (5) | Seventh | 22½ out |
| Sunday, August 28 |
| » Lost to Indians (56-75), 5-2 | Kingdome (24-39) | 49-81 | |
| » W: Lary Sorensen (8-9) L: Mike Moore (4-5) | Sixth | 23½ out |
| Monday, August 29 |
| » Defeated Brewers (74-56), 2-1 | Kingdome (25-39) | 50-81 | |
| » W: Bryan Clark (6-6) L: Don Sutton (7-11) | Sixth | 23½ out |
| Tuesday, August 30 |
| » Lost to Brewers (75-56), 3-2 | Kingdome (25-40) | 50-82 | |
| » W: Tom Candiotti (3-0) L: Jim Beattie (8-12) S: Pete Ladd (16) | Seventh | 24½ out |
| Wednesday, August 31 |
| » Defeated Brewers (75-57), 4-1 | Kingdome (26-40) | 51-82 | |
| » W: Bob Stoddard (7-14) L: Pete Vuckovich (0-1) S: Mike Stanton (6) | Sixth | 24½ out |
| Friday, September 2 |
| » Lost to Yankees (74-58), 5-4 | Kingdome (26-41) | 51-83 | |
| » W: Ray Fontenot (5-2) L: Matt Young (10-13) S: Rich Gossage (16) | Seventh | 25 out |
| » Major-league debuts: Phil Bradley and Harold Reynolds (Mariners) |
| Saturday, September 3 |
| » Lost to Yankees (75-58), 5-3 | Kingdome (26-42) | 51-84 | Lost 2 |
| » W: John Montefusco (11-4) L: Mike Moore (4-6) S: George Frazier (6) | Seventh | 26 out |
| Sunday, September 4 |
| » Lost to Yankees (76-58), 4-3 | Kingdome (26-43) | 51-85 | Lost 3 |
| » W: Ron Guidry (17-8) L: Bryan Clark (6-7) S: Rich Gossage (17) | Seventh | 26 out |
| » Major-league debuts: Darnell Coles (Mariners) |
| Monday, September 5 |
| » Defeated Royals (65-72), 13-6 | Royals Stadium (1-3) | 52-85 | |
| » W: Jim Beattie (9-12) L: Larry Gura (10-17) | Seventh | 26 out |
| Tuesday, September 6 |
| » Defeated Royals (65-73), 3-1 | Royals Stadium (2-3) | 53-85 | Won 2 |
| » W: Bob Stoddard (8-14) L: Bud Black (8-6) S: Bill Caudill (23) | Seventh | 26 out |
| Wednesday, September 7 |
| » Lost to Royals (66-73), 3-2 | Royals Stadium (2-4) | 53-86 | |
| » W: Paul Splittorff (11-7) L: Matt Young (10-14) S: Dan Quisenberry (37) | Seventh | 27 out |
| Friday, September 9 |
| » Defeated Rangers (66-76), 6-4 | Kingdome (27-43) | 54-86 | |
| » W: Mike Moore (5-6) L: Mike Smithson (8-14) S: Mike Stanton (7) | Seventh | 27½ out |
| Saturday, September 10 |
| » Defeated Rangers (66-77), 4-2 | Kingdome (28-43) | 55-86 | Won 2 |
| » W: Bryan Clark (7-7) L: Danny Darwin (7-12) | Seventh | 27½ out |
| » Major-league debuts: Curtis Wilkerson (Rangers) |
| Sunday, September 11 |
| » Lost to Rangers (67-77), 2-1 | Kingdome (28-44) | 55-87 | |
| » W: Dave Stewart (8-3) L: Jim Beattie (9-13) S: Dave Tobik (6) | Seventh | 28½ out |
| Tuesday, September 13 |
| » Lost to Blue Jays (80-66), 6-4 | Kingdome (28-45) | 55-88 | Lost 2 |
| » W: Luis Leal (12-10) L: Bob Stoddard (8-15) S: Roy Lee Jackson (5) | Seventh | 29½ out |
| Wednesday, September 14 |
| » Lost to Blue Jays (81-66), 4-3 | Kingdome (28-46) | 55-89 | Lost 3 |
| » W: Doyle Alexander (4-8) L: Roy Thomas (3-1) | Seventh | 29½ out |
| Thursday, September 15 |
| » Lost to White Sox (86-60), 12-0 | Comiskey Park I (0-4) | 55-90 | Lost 4 |
| » W: La Marr Hoyt (21-10) L: Mike Moore (5-7) | Seventh | 30½ out |
| » Major-league debuts: Tim Hulett (White Sox) |
| Friday, September 16 |
| » Lost to White Sox (87-60), 7-0 | Comiskey Park I (0-5) | 55-91 | Lost 5 |
| » W: Floyd Bannister (15-10) L: Bryan Clark (7-8) | Seventh | 31½ out |
| Saturday, September 17 |
| » Lost to White Sox (88-60), 4-3 | Comiskey Park I (0-6) | 55-92 | Lost 6 |
| » W: Dennis Lamp (7-7) L: Bill Caudill (2-8) | Seventh | 32½ out |
| Sunday, September 18 |
| » Lost to White Sox (89-60), 6-0 | Comiskey Park I (0-7) | 55-93 | Lost 7 |
| » W: Richard Dotson (19-7) L: Bob Stoddard (8-16) | Seventh | 33½ out |
| Monday, September 19 |
| » Defeated Blue Jays (82-69), 9-6 | Exhibition Stadium (3-1) | 56-93 | |
| » W: Matt Young (11-14) L: Dave Geisel (0-3) S: Ed Vande Berg (5) | Sixth | 32½ out |
| Tuesday, September 20 |
| » Lost to Blue Jays (83-69), 7-3 | Exhibition Stadium (3-2) | 56-94 | |
| » W: Dave Stieb (16-12) L: Mike Moore (5-8) | Seventh | 33 out |
| Wednesday, September 21 |
| » Lost to Blue Jays (84-69), 4-3 | Exhibition Stadium (3-3) | 56-95 | Lost 2 |
| » W: Doyle Alexander (5-8) L: Bryan Clark (7-9) | Seventh | 34½ out |
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