| Monday, April 4 |
| » Defeated Athletics (0-1), 8-5 | Oakland-Alameda County Stadium (1-0) | 1-0 | |
| » W: Rick Sutcliffe (1-0) L: Rick Langford (0-1) S: Dan Spillner (1) | First | -- |
| Wednesday, April 6 |
| » Lost to Athletics (1-1), 5-3 | Oakland-Alameda County Stadium (1-1) | 1-1 | |
| » W: Mike Norris (1-0) L: Bert Blyleven (0-1) S: Dave Beard (1) | Third | 1 out |
| Thursday, April 7 |
| » Defeated Athletics (1-2), 9-1 | Oakland-Alameda County Stadium (2-1) | 2-1 | |
| » W: Len Barker (1-0) L: Tom Underwood (0-1) | First | -- |
| Saturday, April 9 |
| » Defeated Orioles (1-2), 8-4 | Cleveland Stadium (1-0) | 3-1 | Won 2 |
| » W: Rick Sutcliffe (2-0) L: Sammy Stewart (0-1) S: Dan Spillner (2) | First | -- |
| Former Indian Bill Kennedy dies in Seattle, WA at the age of 63. |
| Sunday, April 10 |
| » Lost to Orioles (2-2), 13-2 | Cleveland Stadium (1-1) | 3-2 | |
| » W: Dennis Martinez (1-1) L: Lary Sorensen (0-1) | First | -- |
| Tuesday, April 12 |
| » Lost to Rangers (6-1), 2-1 | Cleveland Stadium (1-2) | 3-3 | Lost 2 |
| » W: Rick Honeycutt (2-0) L: Bert Blyleven (0-2) S: Odell Jones (2) | Second | ½ out |
| Wednesday, April 13 |
| » Defeated Rangers (6-2), 4-3 | Cleveland Stadium (2-2) | 4-3 | |
| » W: Len Barker (2-0) L: Mike Mason (0-2) S: Dan Spillner (3) | Second | 1 out |
| Saturday, April 16 |
| » Lost to Orioles (4-3), 2-0 | Memorial Stadium (0-1) | 4-4 | |
| » W: Jim Palmer (1-0) L: Lary Sorensen (0-2) S: Tippy Martinez (1) | First | -- |
| » Defeated Orioles (4-4), 7-4 | Memorial Stadium (1-1) | 5-4 | |
| » W: Neal Heaton (1-0) L: Dennis Martinez (1-2) S: Dan Spillner (4) | First | -- |
| Sunday, April 17 |
| » Lost to Orioles (5-4), 6-1 | Memorial Stadium (1-2) | 5-5 | |
| » W: Mike Flanagan (2-0) L: Bert Blyleven (0-3) | Second | ½ out |
| Monday, April 18 |
| » Lost to Orioles (6-4), 4-1 | Memorial Stadium (1-3) | 5-6 | Lost 2 |
| » W: Scott McGregor (1-0) L: Len Barker (2-1) | Third | 1½ out |
| Tuesday, April 19 |
| » Lost to Blue Jays (5-6), 9-7 | Exhibition Stadium (0-1) | 5-7 | Lost 3 |
| » W: Randy Moffitt (1-0) L: Dan Spillner (0-1) | Fourth | 2½ out |
| Wednesday, April 20 |
| » Lost to Blue Jays (6-6), 4-1 | Exhibition Stadium (0-2) | 5-8 | Lost 4 |
| » W: Dave Stieb (3-1) L: Lary Sorensen (0-3) | Fifth | 2½ out |
| Friday, April 22 |
| » Defeated White Sox (6-7), 5-1 | Cleveland Stadium (3-2) | 6-8 | |
| » W: Bert Blyleven (1-3) L: Floyd Bannister (1-2) | Fourth | 2 out |
| Saturday, April 23 |
| » Defeated White Sox (6-8), 6-3 | Cleveland Stadium (4-2) | 7-8 | Won 2 |
| » W: Len Barker (3-1) L: Dennis Lamp (2-2) | Third | 2 out |
| Sunday, April 24 |
| » Lost to White Sox (7-8), 9-3 | Cleveland Stadium (4-3) | 7-9 | |
| » W: Richard Dotson (2-1) L: Rick Sutcliffe (2-1) | Fourth | 2 out |
| Tuesday, April 26 |
| » Defeated Twins (8-11), 7-1 | Cleveland Stadium (5-3) | 8-9 | |
| » W: Lary Sorensen (1-3) L: Bobby Castillo (1-1) | Fifth | 1½ out |
| Wednesday, April 27 |
| » Lost to Twins (9-11), 5-3 | Cleveland Stadium (5-4) | 8-10 | |
| » W: Albert Williams (2-1) L: Ed Glynn (0-1) S: Rick Lysander (1) | Seventh | 2½ out |
| Friday, April 29 |
| » Lost to Royals (10-6), 6-5 | Royals Stadium (0-1) | 8-11 | Lost 2 |
| » W: Mike Armstrong (2-1) L: Dan Spillner (0-2) | Sixth | 3 out |
| Saturday, April 30 |
| » Defeated Royals (10-7), 5-1 | Royals Stadium (1-1) | 9-11 | |
| » W: Rick Sutcliffe (3-1) L: Steve Renko (1-2) S: Neal Heaton (1) | Fourth | 2 out |
| Sunday, May 1 |
| » Defeated Royals (10-8), 2-1 | Royals Stadium (2-1) | 10-11 | Won 2 |
| » W: Lary Sorensen (2-3) L: Larry Gura (4-1) S: Dan Spillner (5) | Third | 2 out |
| Tuesday, May 3 |
| » Defeated Twins (11-13), 3-1 | Hubert H. Humphrey Metrodome (1-0) | 11-11 | Won 3 |
| » W: Bert Blyleven (2-3) L: Bobby Castillo (1-2) S: Neal Heaton (2) | Fourth | 2 out |
| Wednesday, May 4 |
| » Defeated Twins (11-14), 11-7 | Hubert H. Humphrey Metrodome (2-0) | 12-11 | Won 4 |
| » W: Dan Spillner (1-2) L: Ron Davis (1-1) | Third | 1½ out |
| Thursday, May 5 |
| » Defeated Twins (11-15), 7-5 | Hubert H. Humphrey Metrodome (3-0) | 13-11 | Won 5 |
| » W: Rick Sutcliffe (4-1) L: Brad Havens (3-2) S: Neal Heaton (3) | Third | 1 out |
| Friday, May 6 |
| » Lost to White Sox (11-12), 8-3 | Comiskey Park I (0-1) | 13-12 | |
| » W: Jerry Koosman (1-0) L: Lary Sorensen (2-4) | Fourth | 2 out |
| Saturday, May 7 |
| » Lost to White Sox (12-12), 4-3 | Comiskey Park I (0-2) | 13-13 | Lost 2 |
| » W: La Marr Hoyt (2-4) L: Juan Eichelberger (0-1) S: Kevin Hickey (5) | Fifth | 3 out |
| Sunday, May 8 |
| » Defeated White Sox (12-13), 13-6 | Comiskey Park I (1-2) | 14-13 | |
| » W: Bert Blyleven (3-3) L: Richard Dotson (4-2) | Fourth | 2 out |
| Tuesday, May 10 |
| » Defeated Royals (13-12), 4-1 | Cleveland Stadium (6-4) | 15-13 | Won 2 |
| » W: Len Barker (4-1) L: Vida Blue (0-2) S: Neal Heaton (4) | Fourth | 1½ out |
| Wednesday, May 11 |
| » Defeated Royals (13-13), 2-0 | Cleveland Stadium (7-4) | 16-13 | Won 3 |
| » W: Rick Sutcliffe (5-1) L: Larry Gura (4-3) | Fourth | 1 out |
| Thursday, May 12 |
| » Lost to Blue Jays (16-12), 6-3 | Cleveland Stadium (7-5) | 16-14 | |
| » W: Jim Clancy (3-1) L: Lary Sorensen (2-5) S: Randy Moffitt (3) | Fourth | 1½ out |
| Friday, May 13 |
| » Defeated Blue Jays (16-13), 5-1 | Cleveland Stadium (8-5) | 17-14 | |
| » W: Juan Eichelberger (1-1) L: Mike Morgan (0-2) | Fourth | 1½ out |
| Saturday, May 14 |
| » Lost to Blue Jays (17-13), 8-1 | Cleveland Stadium (8-6) | 17-15 | |
| » W: Luis Leal (3-3) L: Bert Blyleven (3-4) S: Roy Lee Jackson (2) | Fourth | 2½ out |
| Monday, May 16 |
| » Lost to Rangers (18-15), 3-1 | Arlington Stadium (0-1) | 17-16 | Lost 2 |
| » W: Rick Honeycutt (5-2) L: Len Barker (4-2) | Fourth | 2½ out |
| Tuesday, May 17 |
| » Lost to Rangers (19-15), 6-5 | Arlington Stadium (0-2) | 17-17 | Lost 3 |
| » W: Dave Schmidt (1-0) L: Ed Glynn (0-2) | Fifth | 4 out |
| Wednesday, May 18 |
| » Lost to Rangers (20-15), 3-2 | Arlington Stadium (0-3) | 17-18 | Lost 4 |
| » W: Dave Tobik (1-1) L: Neal Heaton (1-1) | Fifth | 5 out |
| Friday, May 20 |
| » Lost to Angels (20-17), 5-4 | Anaheim Stadium (0-1) | 17-19 | Lost 5 |
| » W: Tommy John (3-2) L: Juan Eichelberger (1-2) S: Mike Witt (4) | Sixth | 5½ out |
| Saturday, May 21 |
| » Defeated Angels (20-18), 9-3 | Anaheim Stadium (1-1) | 18-19 | |
| » W: Bert Blyleven (4-4) L: Bill Travers (0-1) | Sixth | 4½ out |
| Sunday, May 22 |
| » Lost to Angels (21-18), 9-0 | Anaheim Stadium (1-2) | 18-20 | |
| » W: Bruce Kison (6-1) L: Len Barker (4-3) | Fifth | 4½ out |
| Monday, May 23 |
| » Lost to Mariners (16-27), 3-2 | Kingdome (0-1) | 18-21 | Lost 2 |
| » W: Bob Stoddard (4-5) L: Rick Sutcliffe (5-2) S: Bill Caudill (9) | Fifth | 4½ out |
| Tuesday, May 24 |
| » Defeated Mariners (16-28), 6-4 | Kingdome (1-1) | 19-21 | |
| » W: Neal Heaton (2-1) L: Bill Caudill (0-3) | Sixth | 4½ out |
| Wednesday, May 25 |
| » Lost to Mariners (17-28), 2-1 | Kingdome (1-2) | 19-22 | |
| » W: Jim Beattie (3-2) L: Juan Eichelberger (1-3) S: Mike Stanton (2) | Fifth | 4½ out |
| Friday, May 27 |
| » Lost to Angels (25-18), 5-4 | Cleveland Stadium (8-7) | 19-23 | Lost 2 |
| » W: Luis Sanchez (5-1) L: Dan Spillner (1-3) | Seventh | 6 out |
| Saturday, May 28 |
| » Lost to Angels (26-18), 7-4 | Cleveland Stadium (8-8) | 19-24 | Lost 3 |
| » W: Geoff Zahn (5-3) L: Len Barker (4-4) | Seventh | 6 out |
| Sunday, May 29 |
| » Lost to Angels (27-18), 6-4 | Cleveland Stadium (8-9) | 19-25 | Lost 4 |
| » W: Mike Witt (3-4) L: Dan Spillner (1-4) | Sixth | 6 out |
| Monday, May 30 |
| » Defeated Angels (27-19), 6-5 | Cleveland Stadium (9-9) | 20-25 | |
| » W: Neal Heaton (3-1) L: Luis Sanchez (5-2) | Seventh | 6 out |
| Tuesday, May 31 |
| » Defeated Mariners (20-30), 5-2 | Cleveland Stadium (10-9) | 21-25 | Won 2 |
| » W: Juan Eichelberger (2-3) L: Gene Nelson (0-1) S: Dan Spillner (6) | Seventh | 5½ out |
| Wednesday, June 1 |
| » Defeated Mariners (20-31), 5-2 | Cleveland Stadium (11-9) | 22-25 | Won 3 |
| » W: Neal Heaton (4-1) L: Gaylord Perry (3-7) | Sixth | 4½ out |
| Thursday, June 2 |
| » Defeated Mariners (20-32), 3-1 | Cleveland Stadium (12-9) | 23-25 | Won 4 |
| » W: Rick Sutcliffe (6-2) L: Bob Stoddard (4-6) | Seventh | 4½ out |
| Saturday, June 4 |
| » Lost to Athletics (24-26), 6-3 | Cleveland Stadium (12-10) | 23-26 | |
| » W: Tom Burgmeier (3-2) L: Rick Waits (0-1) | Seventh | 5 out |
| Sunday, June 5 |
| » Lost to Athletics (25-26), 8-3 | Cleveland Stadium (12-11) | 23-27 | Lost 2 |
| » W: Matt Keough (2-3) L: Neal Heaton (4-2) | Sixth | 5½ out |
| » Lost to Athletics (26-26), 9-2 | Cleveland Stadium (12-12) | 23-28 | Lost 3 |
| » W: Steve McCatty (1-0) L: Len Barker (4-5) | Sixth | 5½ out |
| Tuesday, June 7 |
| » Defeated Yankees (27-26), 2-1 | Yankee Stadium (1-0) | 24-28 | |
| » W: Neal Heaton (5-2) L: Rich Gossage (2-2) | Sixth | 6 out |
| Wednesday, June 8 |
| » Lost to Yankees (28-26), 6-5 | Yankee Stadium (1-1) | 24-29 | |
| » W: Rich Gossage (3-2) L: Dan Spillner (1-5) | Sixth | 7 out |
| Friday, June 10 |
| » Lost to Tigers (30-25), 7-1 | Tiger Stadium (0-1) | 24-30 | Lost 2 |
| » W: Dave Rozema (3-0) L: Lary Sorensen (2-6) S: Aurelio Lopez (9) | Sixth | 8½ out |
| Saturday, June 11 |
| » Defeated Tigers (30-26), 9-1 | Tiger Stadium (1-1) | 25-30 | |
| » W: Juan Eichelberger (3-3) L: Larry Pashnick (1-1) | Sixth | 8½ out |
| Sunday, June 12 |
| » Lost to Tigers (31-26), 4-1 | Tiger Stadium (1-2) | 25-31 | |
| » W: Milt Wilcox (7-6) L: Bert Blyleven (4-5) | Sixth | 9 out |
| » Lost to Tigers (32-26), 3-1 | Tiger Stadium (1-3) | 25-32 | Lost 2 |
| » W: Jack Morris (6-5) L: Len Barker (4-6) | Sixth | 9 out |
| Monday, June 13 |
| » Defeated Yankees (29-29), 9-0 | Cleveland Stadium (13-12) | 26-32 | |
| » W: Rick Sutcliffe (7-2) L: Jay Howell (0-3) | Seventh | 9 out |
| Tuesday, June 14 |
| » Defeated Yankees (29-30), 9-6 | Cleveland Stadium (14-12) | 27-32 | Won 2 |
| » W: Lary Sorensen (3-6) L: Bob Shirley (2-5) S: Dan Spillner (7) | Seventh | 8½ out |
| Wednesday, June 15 |
| » Lost to Yankees (30-30), 8-5 | Cleveland Stadium (14-13) | 27-33 | |
| » W: Shane Rawley (7-5) L: Juan Eichelberger (3-4) | Seventh | 9½ out |
| Thursday, June 16 |
| » Lost to Yankees (31-30), 8-1 | Cleveland Stadium (14-14) | 27-34 | Lost 2 |
| » W: Ron Guidry (9-4) L: Bert Blyleven (4-6) | Seventh | 9½ out |
| Friday, June 17 |
| » Lost to Tigers (35-27), 11-4 | Cleveland Stadium (14-15) | 27-35 | Lost 3 |
| » W: Jack Morris (7-5) L: Len Barker (4-7) | Seventh | 9½ out |
| Saturday, June 18 |
| » Defeated Tigers (35-28), 12-8 | Cleveland Stadium (15-15) | 28-35 | |
| » W: Rick Sutcliffe (8-2) L: Milt Wilcox (7-7) | Seventh | 8½ out |
| Sunday, June 19 |
| » Defeated Tigers (35-29), 7-2 | Cleveland Stadium (16-15) | 29-35 | Won 2 |
| » W: Lary Sorensen (4-6) L: Dan Petry (6-5) | Seventh | 8½ out |
| Monday, June 20 |
| » Lost to Red Sox (33-31), 6-3 | Fenway Park (0-1) | 29-36 | |
| » W: Dennis Eckersley (5-4) L: Juan Eichelberger (3-5) S: Bob Stanley (14) | Seventh | 9 out |
| Tuesday, June 21 |
| » Defeated Red Sox (33-32), 3-1 | Fenway Park (1-1) | 30-36 | |
| » W: Bert Blyleven (5-6) L: Bruce Hurst (4-7) | Seventh | 9 out |
| Wednesday, June 22 |
| » Defeated Red Sox (33-33), 9-4 | Fenway Park (2-1) | 31-36 | Won 2 |
| » W: Len Barker (5-7) L: Bob Ojeda (4-3) | Sixth | 8 out |
| Thursday, June 23 |
| » Defeated Red Sox (33-34), 5-4 | Fenway Park (3-1) | 32-36 | Won 3 |
| » W: Rick Sutcliffe (9-2) L: Doug Bird (1-3) S: Neal Heaton (5) | Sixth | 7½ out |
| Friday, June 24 |
| » Lost to Brewers (31-35), 6-2 | County Stadium (0-1) | 32-37 | |
| » W: Don Sutton (5-4) L: Lary Sorensen (4-7) | Sixth | 7½ out |
| Saturday, June 25 |
| » Lost to Brewers (32-35), 7-2 | County Stadium (0-2) | 32-38 | Lost 2 |
| » W: Jim Slaton (7-2) L: Juan Eichelberger (3-6) | Fifth | 7½ out |
| Sunday, June 26 |
| » Lost to Brewers (33-35), 4-3 | County Stadium (0-3) | 32-39 | Lost 3 |
| » W: Tom Tellmann (5-2) L: Bert Blyleven (5-7) S: Pete Ladd (3) | Sixth | 8½ out |
| Tuesday, June 28 |
| » Lost to Red Sox (36-35), 11-3 | Cleveland Stadium (16-16) | 32-40 | Lost 4 |
| » W: Mark Clear (2-2) L: Rick Sutcliffe (9-3) | Fifth | 8½ out |
| Wednesday, June 29 |
| » Defeated Red Sox (36-36), 5-3 | Cleveland Stadium (17-16) | 33-40 | |
| » W: Len Barker (6-7) L: Bob Stanley (5-4) S: Neal Heaton (6) | Sixth | 9 out |
| » Lost to Red Sox (37-36), 11-10 | Cleveland Stadium (17-17) | 33-41 | |
| » W: John Henry Johnson (1-0) L: Bud Anderson (0-1) S: Doug Bird (1) | Sixth | 9 out |
| Friday, July 1 |
| » Lost to Brewers (36-36), 11-10 | Cleveland Stadium (17-18) | 33-42 | Lost 2 |
| » W: Mike Caldwell (6-7) L: Juan Eichelberger (3-7) S: Jim Slaton (1) | Seventh | 9½ out |
| Saturday, July 2 |
| » Lost to Brewers (37-36), 6-5 | Cleveland Stadium (17-19) | 33-43 | Lost 3 |
| » W: Moose Haas (6-2) L: Bert Blyleven (5-8) S: Pete Ladd (4) | Seventh | 10½ out |
| Sunday, July 3 |
| » Defeated Brewers (37-37), 5-2 | Cleveland Stadium (18-19) | 34-43 | |
| » W: Rick Sutcliffe (10-3) L: Chuck Porter (0-4) S: Bud Anderson (1) | Seventh | 9½ out |
| Monday, July 4 |
| » Lost to Brewers (38-37), 8-3 | Cleveland Stadium (18-20) | 34-44 | |
| » W: Don Sutton (6-4) L: Len Barker (6-8) | Sixth | 10 out |
| Friday, July 8 |
| » Defeated Twins (33-49), 10-4 | Hubert H. Humphrey Metrodome (4-0) | 35-44 | |
| » W: Bert Blyleven (6-8) L: Frank Viola (4-6) | Fifth | 10 out |
| » Major-league debuts: Mike Walters (Twins) |
| Saturday, July 9 |
| » Lost to Twins (34-49), 3-2 | Hubert H. Humphrey Metrodome (4-1) | 35-45 | |
| » W: Ken Schrom (7-3) L: Rick Sutcliffe (10-4) S: Ron Davis (13) | Fifth | 11 out |
| Sunday, July 10 |
| » Lost to Twins (35-49), 6-4 | Hubert H. Humphrey Metrodome (4-2) | 35-46 | Lost 2 |
| » W: Albert Williams (5-9) L: Juan Eichelberger (3-8) S: Ron Davis (14) | Fifth | 12 out |
| Monday, July 11 |
| » Lost to White Sox (42-39), 9-2 | Comiskey Park I (1-3) | 35-47 | Lost 3 |
| » W: Britt Burns (5-5) L: Len Barker (6-9) | Sixth | 13 out |
| Tuesday, July 12 |
| » Lost to White Sox (43-39), 8-0 | Comiskey Park I (1-4) | 35-48 | Lost 4 |
| » W: Floyd Bannister (4-9) L: Lary Sorensen (4-8) | Sixth | 14 out |
| Wednesday, July 13 |
| » Lost to White Sox (44-39), 5-1 | Comiskey Park I (1-5) | 35-49 | Lost 5 |
| » W: La Marr Hoyt (10-9) L: Bert Blyleven (6-9) | Sixth | 14 out |
| Thursday, July 14 |
| » Defeated Royals (39-41), 4-3 | Cleveland Stadium (19-20) | 36-49 | |
| » W: Rick Sutcliffe (11-4) L: Mike Armstrong (4-4) | Sixth | 14 out |
| Friday, July 15 |
| » Lost to Royals (40-41), 10-0 | Cleveland Stadium (19-21) | 36-50 | |
| » W: Paul Splittorff (7-3) L: Juan Eichelberger (3-9) | Seventh | 15 out |
| Saturday, July 16 |
| » Defeated Royals (40-42), 17-3 | Cleveland Stadium (20-21) | 37-50 | |
| » W: Len Barker (7-9) L: Gaylord Perry (3-11) S: Neal Heaton (7) | Seventh | 15 out |
| Sunday, July 17 |
| » Lost to Royals (41-42), 7-2 | Cleveland Stadium (20-22) | 37-51 | |
| » W: Don Hood (2-1) L: Dan Spillner (1-6) | Seventh | 15 out |
| Monday, July 18 |
| » Lost to White Sox (46-42), 5-3 | Cleveland Stadium (20-23) | 37-52 | Lost 2 |
| » W: La Marr Hoyt (11-9) L: Juan Eichelberger (3-10) S: Salome Barojas (9) | Sixth | 16 out |
| Tuesday, July 19 |
| » Defeated White Sox (46-43), 5-4 | Cleveland Stadium (21-23) | 38-52 | |
| » W: Rick Sutcliffe (12-4) L: Dick Tidrow (2-2) | Seventh | 15 out |
| Wednesday, July 20 |
| » Lost to White Sox (47-43), 8-2 | Cleveland Stadium (21-24) | 38-53 | |
| » W: Richard Dotson (9-6) L: Neal Heaton (5-3) | Fifth | 15 out |
| Friday, July 22 |
| » Defeated Twins (37-58), 8-5 | Cleveland Stadium (22-24) | 39-53 | |
| » W: Jamie Easterly (1-1) L: Rick Lysander (2-9) S: Dan Spillner (8) | Seventh | 14½ out |
| Saturday, July 23 |
| » Lost to Twins (38-58), 5-2 | Cleveland Stadium (22-25) | 39-54 | |
| » W: Albert Williams (6-11) L: Len Barker (7-10) S: Ron Davis (16) | Seventh | 15½ out |
| Sunday, July 24 |
| » Lost to Twins (39-58), 7-5 | Cleveland Stadium (22-26) | 39-55 | Lost 2 |
| » W: Bobby Castillo (6-8) L: Rick Sutcliffe (12-5) S: Ron Davis (17) | Sixth | 16 out |
| » Lost to Twins (40-58), 5-4 | Cleveland Stadium (22-27) | 39-56 | Lost 3 |
| » W: Brad Havens (5-6) L: Tom Brennan (0-1) S: Ron Davis (18) | Sixth | 16 out |
| Monday, July 25 |
| » Lost to Royals (45-45), 6-1 | Royals Stadium (2-2) | 39-57 | Lost 4 |
| » W: Paul Splittorff (9-3) L: Neal Heaton (5-4) S: Dan Quisenberry (24) | Fifth | 16 out |
| Tuesday, July 26 |
| » Defeated Royals (45-46), 2-0 | Royals Stadium (3-2) | 40-57 | |
| » W: Lary Sorensen (5-8) L: Steve Renko (5-8) | Sixth | 16 out |
| Wednesday, July 27 |
| » Lost to Royals (46-46), 5-4 | Royals Stadium (3-3) | 40-58 | |
| » W: Gaylord Perry (4-11) L: Len Barker (7-11) S: Dan Quisenberry (25) | Seventh | 17 out |
| Friday, July 29 |
| » Lost to Blue Jays (56-42), 4-2 | Exhibition Stadium (0-3) | 40-59 | Lost 2 |
| » W: Jim Clancy (11-6) L: Rick Sutcliffe (12-6) | Seventh | 18 out |
| Saturday, July 30 |
| » Lost to Blue Jays (57-42), 6-5 | Exhibition Stadium (0-4) | 40-60 | Lost 3 |
| » W: Joey McLaughlin (4-2) L: Bud Anderson (0-2) | Seventh | 19 out |
| » Major-league debuts: Joe Carter (Indians) |
| Sunday, July 31 |
| » Defeated Blue Jays (57-43), 16-11 | Exhibition Stadium (1-4) | 41-60 | |
| » Manager: Pat Corrales |
| » W: Juan Eichelberger (4-10) L: Jim Acker (2-1) S: Bud Anderson (2) | Seventh | 19 out |
| Monday, August 1 |
| » Defeated Blue Jays (57-44), 6-0 | Exhibition Stadium (2-4) | 42-60 | Won 2 |
| » W: Len Barker (8-11) L: Doyle Alexander (0-5) | Seventh | 18½ out |
| Tuesday, August 2 |
| » Defeated Orioles (59-41), 3-1 | Cleveland Stadium (23-27) | 43-60 | Won 3 |
| » W: Bert Blyleven (7-9) L: Dennis Martinez (6-13) S: Bud Anderson (3) | Seventh | 16½ out |
| » Defeated Orioles (59-42), 4-3 | Cleveland Stadium (24-27) | 44-60 | Won 4 |
| » W: Tom Brennan (1-1) L: Allan Ramirez (4-2) S: Bud Anderson (4) | Seventh | 16½ out |
| Wednesday, August 3 |
| » Lost to Orioles (60-42), 8-2 | Cleveland Stadium (24-28) | 44-61 | |
| » W: Storm Davis (10-4) L: Rick Sutcliffe (12-7) | Seventh | 17½ out |
| Thursday, August 4 |
| » Lost to Orioles (61-42), 4-3 | Cleveland Stadium (24-29) | 44-62 | Lost 2 |
| » W: Scott McGregor (14-4) L: Bud Anderson (0-3) S: Tippy Martinez (11) | Seventh | 18½ out |
| Friday, August 5 |
| » Lost to Rangers (51-55), 2-0 | Cleveland Stadium (24-30) | 44-63 | Lost 3 |
| » W: Mike Smithson (7-10) L: Lary Sorensen (5-9) S: Odell Jones (9) | Seventh | 19½ out |
| Saturday, August 6 |
| » Lost to Rangers (52-55), 6-1 | Cleveland Stadium (24-31) | 44-64 | Lost 4 |
| » W: Frank Tanana (5-4) L: Len Barker (8-12) | Seventh | 19½ out |
| Former Indian Jimmy Wasdell dies in New Port Richey, FL at the age of 70. |
| Sunday, August 7 |
| » Lost to Rangers (53-55), 4-3 | Cleveland Stadium (24-32) | 44-65 | Lost 5 |
| » W: Charlie Hough (9-10) L: Dan Spillner (1-7) S: Victor Cruz (1) | Seventh | 19 out |
| » Defeated Rangers (53-56), 7-0 | Cleveland Stadium (25-32) | 45-65 | |
| » W: Tom Brennan (2-1) L: Jon Matlack (2-3) | Seventh | 19 out |
| Monday, August 8 |
| » Defeated Orioles (62-45), 9-4 | Memorial Stadium (2-3) | 46-65 | Won 2 |
| » W: Rick Sutcliffe (13-7) L: Storm Davis (10-5) | Seventh | 18 out |
| Tuesday, August 9 |
| » Defeated Orioles (62-46), 4-3 | Memorial Stadium (3-3) | 47-65 | Won 3 |
| » W: Neal Heaton (6-4) L: Scott McGregor (14-5) | Seventh | 17 out |
| Wednesday, August 10 |
| » Defeated Orioles (62-47), 4-3 | Memorial Stadium (4-3) | 48-65 | Won 4 |
| » W: Lary Sorensen (6-9) L: Mike Boddicker (8-6) | Sixth | 16 out |
| Friday, August 12 |
| » Lost to Rangers (55-58), 6-2 | Arlington Stadium (0-4) | 48-66 | |
| » W: Frank Tanana (6-4) L: Tom Brennan (2-2) S: Odell Jones (10) | Sixth | 16½ out |
| Saturday, August 13 |
| » Lost to Rangers (56-58), 4-3 | Arlington Stadium (0-5) | 48-67 | Lost 2 |
| » W: Charlie Hough (10-10) L: Rick Sutcliffe (13-8) S: Victor Cruz (2) | Seventh | 17½ out |
| Sunday, August 14 |
| » Defeated Rangers (56-59), 3-0 | Arlington Stadium (1-5) | 49-67 | |
| » W: Neal Heaton (7-4) L: Rick Honeycutt (14-8) | Seventh | 16½ out |
| Monday, August 15 |
| » Lost to Blue Jays (65-52), 3-2 | Cleveland Stadium (25-33) | 49-68 | |
| » W: Randy Moffitt (6-0) L: Dan Spillner (1-8) | Sixth | 17½ out |
| Tuesday, August 16 |
| » Defeated Blue Jays (65-53), 3-2 | Cleveland Stadium (26-33) | 50-68 | |
| » W: Jamie Easterly (2-1) L: Randy Moffitt (6-1) | Seventh | 17 out |
| » Lost to Blue Jays (66-53), 9-6 | Cleveland Stadium (26-34) | 50-69 | |
| » W: Joey McLaughlin (6-2) L: Bud Anderson (0-4) | Seventh | 17 out |
| Former Indian Earl Averill dies in Everett, WA at the age of 82. |
| Wednesday, August 17 |
| » Lost to Blue Jays (67-53), 6-5 | Cleveland Stadium (26-35) | 50-70 | Lost 2 |
| » W: Joey McLaughlin (7-2) L: Rick Sutcliffe (13-9) S: Roy Lee Jackson (3) | Seventh | 18½ out |
| Friday, August 19 |
| » Defeated Mariners (46-75), 6-5 | Cleveland Stadium (27-35) | 51-70 | |
| » W: Neal Heaton (8-4) L: Karl Best (0-1) S: Jamie Easterly (2) | Seventh | 18½ out |
| » Major-league debuts: Karl Best (Mariners) |
| Saturday, August 20 |
| » Defeated Mariners (46-76), 3-2 | Cleveland Stadium (28-35) | 52-70 | Won 2 |
| » W: Jamie Easterly (3-1) L: Jim Beattie (8-10) | Seventh | 18½ out |
| Sunday, August 21 |
| » Lost to Mariners (47-76), 7-2 | Cleveland Stadium (28-36) | 52-71 | |
| » W: Glenn Abbott (5-3) L: Mike Jeffcoat (0-1) S: Mike Stanton (4) | Seventh | 18½ out |
| » Major-league debuts: Mike Jeffcoat (Indians) |
| Monday, August 22 |
| » Lost to Angels (58-66), 7-3 | Cleveland Stadium (28-37) | 52-72 | Lost 2 |
| » W: Bruce Kison (11-5) L: Dan Spillner (1-9) | Seventh | 19½ out |
| Tuesday, August 23 |
| » Lost to Angels (59-66), 5-2 | Cleveland Stadium (28-38) | 52-73 | Lost 3 |
| » W: Mike Witt (7-9) L: Len Barker (8-13) S: Luis Sanchez (6) | Seventh | 19½ out |
| Wednesday, August 24 |
| » Defeated Athletics (62-66), 1-0 | Cleveland Stadium (29-38) | 53-73 | |
| » W: Neal Heaton (9-4) L: Tim Conroy (6-6) | Seventh | 19 out |
| » Defeated Athletics (62-67), 4-2 | Cleveland Stadium (30-38) | 54-73 | Won 2 |
| » W: Lary Sorensen (7-9) L: Keith Atherton (2-1) S: Jamie Easterly (3) | Seventh | 19 out |
| Thursday, August 25 |
| » Lost to Athletics (63-67), 6-0 | Cleveland Stadium (30-39) | 54-74 | |
| » W: Steve McCatty (5-6) L: Mike Jeffcoat (0-2) | Seventh | 20 out |
| Friday, August 26 |
| » Defeated Mariners (48-80), 4-1 | Kingdome (2-2) | 55-74 | |
| » W: Rick Sutcliffe (14-9) L: Bob Stoddard (6-14) | Seventh | 19½ out |
| Saturday, August 27 |
| » Lost to Mariners (49-80), 6-3 | Kingdome (2-3) | 55-75 | |
| » W: Matt Young (10-12) L: Juan Eichelberger (4-11) S: Mike Stanton (5) | Seventh | 20½ out |
| Sunday, August 28 |
| » Defeated Mariners (49-81), 5-2 | Kingdome (3-3) | 56-75 | |
| » W: Lary Sorensen (8-9) L: Mike Moore (4-5) | Seventh | 20½ out |
| Monday, August 29 |
| » Defeated Angels (60-71), 6-4 | Anaheim Stadium (2-2) | 57-75 | Won 2 |
| » W: Neal Heaton (10-4) L: Mike Witt (7-10) S: Bud Anderson (5) | Seventh | 20½ out |
| Tuesday, August 30 |
| » Lost to Angels (61-71), 10-6 | Anaheim Stadium (2-3) | 57-76 | |
| » W: Rick Steirer (2-1) L: Mike Jeffcoat (0-3) | Seventh | 21½ out |
| Wednesday, August 31 |
| » Defeated Angels (61-72), 7-5 | Anaheim Stadium (3-3) | 58-76 | |
| » W: Rick Sutcliffe (15-9) L: Luis Sanchez (8-7) S: Jamie Easterly (4) | Seventh | 21½ out |
| Friday, September 2 |
| » Defeated Athletics (66-71), 4-2 | Oakland-Alameda County Stadium (3-1) | 59-76 | Won 2 |
| » W: Lary Sorensen (9-9) L: Gorman Heimueller (3-4) S: Bud Anderson (6) | Seventh | 21 out |
| Saturday, September 3 |
| » Defeated Athletics (66-72), 13-6 | Oakland-Alameda County Stadium (4-1) | 60-76 | Won 3 |
| » W: Dan Spillner (2-9) L: Dave Beard (5-5) | Seventh | 21 out |
| » Major-league debuts: Bert Bradley (Athletics) |
| Sunday, September 4 |
| » Defeated Athletics (66-73), 9-2 | Oakland-Alameda County Stadium (5-1) | 61-76 | Won 4 |
| » W: Rick Sutcliffe (16-9) L: Steve McCatty (5-7) | Seventh | 21 out |
| Monday, September 5 |
| » Defeated Tigers (77-60), 3-2 | Cleveland Stadium (31-39) | 62-76 | Won 5 |
| » W: Bud Anderson (1-4) L: Jack Morris (18-9) | Seventh | 20 out |
| Wednesday, September 7 |
| » Defeated Tigers (77-61), 7-1 | Cleveland Stadium (32-39) | 63-76 | Won 6 |
| » W: Lary Sorensen (10-9) L: Milt Wilcox (8-10) | Seventh | 21 out |
| » Lost to Tigers (78-61), 7-3 | Cleveland Stadium (32-40) | 63-77 | |
| » W: Dan Petry (16-8) L: Ernie Camacho (0-1) | Seventh | 21 out |
| Friday, September 9 |
| » Lost to Red Sox (68-73), 6-4 | Cleveland Stadium (32-41) | 63-78 | Lost 2 |
| » W: John Tudor (11-10) L: Neal Heaton (10-5) S: Bob Stanley (28) | Sixth | 21 out |
| Saturday, September 10 |
| » Defeated Red Sox (68-74), 8-6 | Cleveland Stadium (33-41) | 64-78 | |
| » W: Rich Barnes (1-0) L: Doug Bird (1-4) S: Bud Anderson (7) | Seventh | 21½ out |
| Sunday, September 11 |
| » Lost to Red Sox (69-74), 4-1 | Cleveland Stadium (33-42) | 64-79 | |
| » W: Bob Ojeda (9-7) L: Lary Sorensen (10-10) | Seventh | 22½ out |
| Monday, September 12 |
| » Lost to Tigers (82-62), 5-1 | Tiger Stadium (1-4) | 64-80 | Lost 2 |
| » W: Milt Wilcox (9-10) L: Bert Blyleven (7-10) | Seventh | 23 out |
| Tuesday, September 13 |
| » Lost to Tigers (83-62), 3-2 | Tiger Stadium (1-5) | 64-81 | Lost 3 |
| » W: Jack Morris (19-10) L: Rick Behenna (3-4) | Seventh | 24½ out |
| Wednesday, September 14 |
| » Lost to Tigers (84-62), 5-0 | Tiger Stadium (1-6) | 64-82 | Lost 4 |
| » W: Glenn Abbott (7-4) L: Rick Sutcliffe (16-10) | Seventh | 25½ out |
| Saturday, September 17 |
| » Defeated Yankees (82-64), 7-6 | Cleveland Stadium (34-42) | 65-82 | |
| » W: Jamie Easterly (4-1) L: George Frazier (3-4) | Seventh | 25½ out |
| Sunday, September 18 |
| » Defeated Yankees (82-65), 10-6 | Cleveland Stadium (35-42) | 66-82 | Won 2 |
| » W: Mike Jeffcoat (1-3) L: Dave Righetti (14-8) | Seventh | 26 out |
| » Lost to Yankees (83-65), 13-8 | Cleveland Stadium (35-43) | 66-83 | |
| » W: Ray Fontenot (8-2) L: Rick Behenna (3-5) | Seventh | 26 out |
| Tuesday, September 20 |
| » Lost to Brewers (80-71), 11-7 | Cleveland Stadium (35-44) | 66-84 | Lost 2 |
| » W: Jim Slaton (13-6) L: Bud Anderson (1-5) S: Pete Ladd (21) | Seventh | 26½ out |
| Wednesday, September 21 |
| » Lost to Brewers (81-71), 10-7 | Cleveland Stadium (35-45) | 66-85 | Lost 3 |
| » W: Don Sutton (8-13) L: Neal Heaton (10-6) S: Pete Ladd (22) | Seventh | 28 out |
| Thursday, September 22 |
| » Defeated Brewers (81-72), 9-5 | Cleveland Stadium (36-45) | 67-85 | |
| » W: Lary Sorensen (11-10) L: Tom Candiotti (4-3) | Seventh | 27 out |
| » Major-league debuts: Andy Beene (Brewers) |
| Friday, September 23 |
| » Lost to Yankees (85-67), 7-4 | Yankee Stadium (1-2) | 67-86 | |
| » W: George Frazier (4-4) L: Jamie Easterly (4-2) | Seventh | 28 out |
| Saturday, September 24 |
| » Lost to Yankees (86-67), 9-1 | Yankee Stadium (1-3) | 67-87 | Lost 2 |
| » W: Ron Guidry (20-9) L: Rick Sutcliffe (16-11) | Seventh | 28 out |
| Sunday, September 25 |
| » Lost to Yankees (87-67), 6-4 | Yankee Stadium (1-4) | 67-88 | Lost 3 |
| » W: John Montefusco (13-4) L: Rich Barnes (1-1) S: Rich Gossage (22) | Seventh | 29 out |
| Monday, September 26 |
| » Defeated Yankees (87-68), 7-0 | Yankee Stadium (2-4) | 68-88 | |
| » W: Neal Heaton (11-6) L: Bob Shirley (5-8) | Seventh | 28½ out |
| Tuesday, September 27 |
| » Lost to Brewers (83-74), 8-4 | County Stadium (0-4) | 68-89 | |
| » W: Mike Caldwell (12-11) L: Lary Sorensen (11-11) | Seventh | 28½ out |
| Wednesday, September 28 |
| » Lost to Brewers (84-74), 6-4 | County Stadium (0-5) | 68-90 | Lost 2 |
| » W: Jim Slaton (14-6) L: Jamie Easterly (4-3) | Seventh | 28½ out |
| Thursday, September 29 |
| » Defeated Brewers (84-75), 4-2 | County Stadium (1-5) | 69-90 | |
| » W: Rick Sutcliffe (17-11) L: Tom Candiotti (4-4) | Seventh | 27½ out |
| Friday, September 30 |
| » Lost to Red Sox (77-83), 10-0 | Fenway Park (3-2) | 69-91 | |
| » W: Dennis Eckersley (9-13) L: Neal Heaton (11-7) | Seventh | 28 out |
| Saturday, October 1 |
| » Defeated Red Sox (77-84), 3-1 | Fenway Park (4-2) | 70-91 | |
| » W: Lary Sorensen (12-11) L: Oil Can Boyd (4-8) | Seventh | 27 out |
| Sunday, October 2 |
| » Lost to Red Sox (78-84), 3-1 | Fenway Park (4-3) | 70-92 | |
| » W: Al Nipper (1-1) L: Bud Anderson (1-6) | Seventh | 28 out |
| Tuesday, October 18 |
| Former Indian Willie Jones dies in Cincinnati, OH at the age of 59. |
Game information provided by Retrosheet (www.retrosheet.org) |