| Wednesday, January 26 |
| Former Cardinal Del Rice dies in Buena Park, CA at the age of 61. |
| Tuesday, April 5 |
| » Lost to Pirates (1-0), 7-1 | Busch Stadium II (0-1) | 0-1 | |
| » W: John Candelaria (1-0) L: Bob Forsch (0-1) | Third | 1 out |
| » Major-league debuts: Rafael Santana (Cardinals) |
| Saturday, April 9 |
| » Defeated Mets (2-1), 5-0 | Shea Stadium (1-0) | 1-1 | |
| » W: Joaquin Andujar (1-0) L: Mike Torrez (0-1) | Third | 2 out |
| Sunday, April 10 |
| » Major-league debuts: Craig McMurtry (Braves) |
| Tuesday, April 12 |
| » Defeated Pirates (5-1), 4-3 | Three Rivers Stadium (1-0) | 2-1 | Won 2 |
| » W: Bruce Sutter (1-0) L: Jim Bibby (1-1) S: Eric Rasmussen (1) | Third | 1½ out |
| Wednesday, April 13 |
| » Defeated Pirates (5-2), 9-1 | Three Rivers Stadium (2-0) | 3-1 | Won 3 |
| » W: Joaquin Andujar (2-0) L: Lee Tunnell (0-1) | First | -- |
| Thursday, April 14 |
| » Defeated Mets (2-4), 7-1 | Busch Stadium II (1-1) | 4-1 | Won 4 |
| » W: Bob Forsch (1-1) L: Mike Torrez (0-2) | First | -- |
| Friday, April 15 |
| » Defeated Mets (2-5), 5-2 | Busch Stadium II (2-1) | 5-1 | Won 5 |
| » W: John Stuper (1-0) L: Scott Holman (0-1) S: Bruce Sutter (1) | First | -- |
| Former Cardinal Bill Sarni dies in Creve Coeur, MO at the age of 56. |
| Saturday, April 16 |
| » Defeated Mets (2-6), 6-2 | Busch Stadium II (3-1) | 6-1 | Won 6 |
| » W: Dave LaPoint (1-0) L: Ed Lynch (0-1) | First | -- |
| Thursday, April 21 |
| » Lost to Expos (7-4), 6-5 | Stade Olympique (0-1) | 6-2 | |
| » W: Scott Sanderson (3-0) L: Joaquin Andujar (2-1) | First | -- |
| Friday, April 22 |
| » Lost to Padres (7-8), 4-1 | Busch Stadium II (3-2) | 6-3 | Lost 2 |
| » W: Dave Dravecky (3-1) L: Bob Forsch (1-2) | Second | 1½ out |
| Saturday, April 23 |
| » Defeated Padres (7-9), 9-5 | Busch Stadium II (4-2) | 7-3 | |
| » W: John Martin (1-0) L: Eric Show (2-1) | First | -- |
| Sunday, April 24 |
| » Defeated Padres (7-10), 2-0 | Busch Stadium II (5-2) | 8-3 | Won 2 |
| » W: Dave LaPoint (2-0) L: Andy Hawkins (0-1) S: Bruce Sutter (2) | First | -- |
| Monday, April 25 |
| » Lost to Dodgers (12-4), 8-0 | Busch Stadium II (5-3) | 8-4 | |
| » W: Fernando Valenzuela (3-1) L: Joaquin Andujar (2-2) | Second | ½ out |
| Tuesday, April 26 |
| » Lost to Dodgers (13-4), 3-1 | Busch Stadium II (5-4) | 8-5 | Lost 2 |
| » W: Burt Hooton (1-1) L: John Stuper (1-1) S: Steve Howe (4) | Second | ½ out |
| Wednesday, April 27 |
| » Defeated Dodgers (13-5), 7-6 | Busch Stadium II (6-4) | 9-5 | |
| » W: Bruce Sutter (2-0) L: Alejandro Pena (2-1) | First | -- |
| Friday, April 29 |
| » Game at Busch Stadium II interrupted in the 14th inning with the score of Giants 5, Cardinals 5. Completed on April 30. |
| Saturday, April 30 |
| » Defeated Giants (6-14), 6-5 | Busch Stadium II (7-4) | 10-5 | Won 2 |
| » W: Doug Bair (1-0) L: Mark Calvert (0-2) | First | -- |
| » Lost to Giants (7-14), 5-0 | Busch Stadium II (7-5) | 10-6 | |
| » W: Andy McGaffigan (1-2) L: Joaquin Andujar (2-3) S: Gary Lavelle (1) | First | -- |
| Sunday, May 1 |
| » Defeated Giants (7-15), 10-9 | Busch Stadium II (8-5) | 11-6 | |
| » W: John Stuper (2-1) L: Fred Breining (2-3) S: Bruce Sutter (3) | First | -- |
| Tuesday, May 3 |
| » Lost to Padres (11-12), 4-3 | San Diego/Jack Murphy Stadium (0-1) | 11-7 | |
| » W: Dave Dravecky (4-1) L: Bob Forsch (1-3) S: Gary Lucas (4) | Second | 1½ out |
| Wednesday, May 4 |
| » Lost to Padres (12-12), 10-0 | San Diego/Jack Murphy Stadium (0-2) | 11-8 | Lost 2 |
| » W: Eric Show (4-1) L: Joaquin Andujar (2-4) | Second | 1½ out |
| Thursday, May 5 |
| » Defeated Padres (12-13), 4-3 | San Diego/Jack Murphy Stadium (1-2) | 12-8 | |
| » W: Bruce Sutter (3-0) L: Gary Lucas (0-2) | Second | 1 out |
| Friday, May 6 |
| » Lost to Dodgers (18-7), 16-10 | Dodger Stadium (0-1) | 12-9 | |
| » W: Dave Stewart (2-0) L: Jeff Lahti (0-1) S: Tom Niedenfuer (1) | Second | 2 out |
| Saturday, May 7 |
| » Lost to Dodgers (19-7), 5-3 | Dodger Stadium (0-2) | 12-10 | Lost 2 |
| » W: Steve Howe (2-0) L: Doug Bair (1-1) | Third | 2 out |
| Sunday, May 8 |
| » Lost to Dodgers (20-7), 6-4 | Dodger Stadium (0-3) | 12-11 | Lost 3 |
| » W: Jerry Reuss (4-1) L: Joaquin Andujar (2-5) S: Steve Howe (6) | Third | 2½ out |
| » Major-league debuts: Dave Anderson (Dodgers) |
| Monday, May 9 |
| » Lost to Giants (13-15), 5-4 | Candlestick Park (0-1) | 12-12 | Lost 4 |
| » W: Gary Lavelle (1-0) L: Bruce Sutter (3-1) | Third | 3 out |
| Tuesday, May 10 |
| » Defeated Giants (13-16), 8-4 | Candlestick Park (1-1) | 13-12 | |
| » W: John Stuper (3-1) L: Andy McGaffigan (2-3) | Third | 3 out |
| Thursday, May 12 |
| » Defeated Expos (15-12), 4-0 | Busch Stadium II (9-5) | 14-12 | Won 2 |
| » W: Bob Forsch (2-3) L: Bill Gullickson (3-4) | Third | 1½ out |
| Friday, May 13 |
| » Defeated Expos (15-13), 5-4 | Busch Stadium II (10-5) | 15-12 | Won 3 |
| » W: John Martin (2-0) L: Bryn Smith (0-2) | Second | ½ out |
| » Major-league debuts: Dave Von Ohlen (Cardinals) |
| Saturday, May 14 |
| » Defeated Expos (15-14), 3-2 | Busch Stadium II (11-5) | 16-12 | Won 4 |
| » W: Bruce Sutter (4-1) L: Jeff Reardon (1-1) | First | -- |
| Sunday, May 15 |
| » Defeated Expos (15-15), 4-2 | Busch Stadium II (12-5) | 17-12 | Won 5 |
| » W: John Stuper (4-1) L: Scott Sanderson (3-3) | First | -- |
| Monday, May 16 |
| Former Cardinal Mel Wright dies in Houston, TX at the age of 56. |
| Tuesday, May 17 |
| » Defeated Astros (16-22), 8-4 | Busch Stadium II (13-5) | 18-12 | Won 6 |
| » W: Bob Forsch (3-3) L: Joe Niekro (1-4) | First | -- |
| Wednesday, May 18 |
| » Defeated Astros (16-23), 9-5 | Busch Stadium II (14-5) | 19-12 | Won 7 |
| » W: Joaquin Andujar (3-5) L: Frank DiPino (3-2) | First | -- |
| Friday, May 20 |
| » Lost to Braves (23-13), 2-1 | Busch Stadium II (14-6) | 19-13 | |
| » W: Craig McMurtry (6-1) L: Dave LaPoint (2-1) S: Terry Forster (5) | First | -- |
| Saturday, May 21 |
| » Lost to Braves (24-13), 4-1 | Busch Stadium II (14-7) | 19-14 | Lost 2 |
| » W: Steve Bedrosian (3-2) L: John Stuper (4-2) | First | -- |
| Sunday, May 22 |
| » Lost to Braves (25-13), 7-5 | Busch Stadium II (14-8) | 19-15 | Lost 3 |
| » W: Steve Bedrosian (4-2) L: Bruce Sutter (4-2) | Second | 1 out |
| Monday, May 23 |
| » Lost to Reds (19-22), 2-1 | Riverfront Stadium (0-1) | 19-16 | Lost 4 |
| » W: Joe Price (3-2) L: Joaquin Andujar (3-6) S: Bill Scherrer (1) | Second | 1 out |
| Tuesday, May 24 |
| » Defeated Reds (19-23), 7-1 | Riverfront Stadium (1-1) | 20-16 | |
| » W: Dave LaPoint (3-1) L: Bruce Berenyi (3-5) | First | -- |
| Wednesday, May 25 |
| » Defeated Reds (19-24), 7-2 | Riverfront Stadium (2-1) | 21-16 | Won 2 |
| » W: John Stuper (5-2) L: Ted Power (1-2) | First | -- |
| Thursday, May 26 |
| » Defeated Astros (19-26), 5-3 | Astrodome (1-0) | 22-16 | Won 3 |
| » W: Dave VonOhlen (1-0) L: Mike LaCoss (3-4) S: Bruce Sutter (4) | First | -- |
| Friday, May 27 |
| » Defeated Astros (19-27), 3-1 | Astrodome (2-0) | 23-16 | Won 4 |
| » W: Jeff Lahti (1-1) L: Bob Knepper (1-7) | First | -- |
| Saturday, May 28 |
| » Lost to Astros (20-27), 9-2 | Astrodome (2-1) | 23-17 | |
| » W: Joe Niekro (3-4) L: John Martin (2-1) | First | -- |
| Sunday, May 29 |
| » Defeated Astros (20-28), 7-3 | Astrodome (3-1) | 24-17 | |
| » W: Dave LaPoint (4-1) L: Mike Scott (0-3) | First | -- |
| Monday, May 30 |
| » Defeated Reds (21-27), 9-1 | Busch Stadium II (15-8) | 25-17 | Won 2 |
| » W: John Stuper (6-2) L: Ted Power (1-3) | First | -- |
| Tuesday, May 31 |
| » Lost to Reds (22-27), 2-1 | Busch Stadium II (15-9) | 25-18 | |
| » W: Charlie Puleo (1-2) L: Joaquin Andujar (3-7) S: Bill Scherrer (3) | First | -- |
| Wednesday, June 1 |
| » Defeated Reds (22-28), 8-3 | Busch Stadium II (16-9) | 26-18 | |
| » W: John Martin (3-1) L: Mario Soto (7-3) | First | -- |
| Thursday, June 2 |
| » Lost to Braves (32-17), 8-1 | Atlanta-Fulton County Stadium (0-1) | 26-19 | |
| » W: Pete Falcone (3-1) L: Bob Forsch (3-4) S: Terry Forster (7) | First | -- |
| Friday, June 3 |
| » Lost to Braves (33-17), 5-3 | Atlanta-Fulton County Stadium (0-2) | 26-20 | Lost 2 |
| » W: Rick Camp (5-4) L: Dave LaPoint (4-2) S: Steve Bedrosian (7) | First | -- |
| Saturday, June 4 |
| » Lost to Braves (34-17), 6-4 | Atlanta-Fulton County Stadium (0-3) | 26-21 | Lost 3 |
| » W: Donnie Moore (2-0) L: Joaquin Andujar (3-8) S: Terry Forster (8) | First | -- |
| Sunday, June 5 |
| » Defeated Braves (34-18), 8-3 | Atlanta-Fulton County Stadium (1-3) | 27-21 | |
| » W: John Stuper (7-2) L: Phil Niekro (2-5) S: Doug Bair (2) | First | -- |
| Tuesday, June 7 |
| » Defeated Phillies (21-25), 2-1 | Veteran's Stadium (1-0) | 28-21 | Won 2 |
| » W: Bob Forsch (4-4) L: Steve Carlton (6-6) | First | -- |
| Wednesday, June 8 |
| » Lost to Phillies (22-25), 7-4 | Veteran's Stadium (1-1) | 28-22 | |
| » W: Al Holland (2-0) L: Bruce Sutter (4-3) | First | -- |
| Thursday, June 9 |
| » Lost to Phillies (23-25), 6-5 | Veteran's Stadium (1-2) | 28-23 | Lost 2 |
| » W: Ron Reed (3-1) L: Dave VonOhlen (1-1) | First | -- |
| Friday, June 10 |
| » Lost to Cubs (25-29), 7-0 | Wrigley Field (0-1) | 28-24 | Lost 3 |
| » W: Fergie Jenkins (3-3) L: John Stuper (7-3) | First | -- |
| Saturday, June 11 |
| » Defeated Cubs (25-30), 5-4 | Wrigley Field (1-1) | 29-24 | |
| » W: Bruce Sutter (5-3) L: Lee Smith (1-3) S: Joaquin Andujar (1) | First | -- |
| Sunday, June 12 |
| » Lost to Cubs (26-30), 6-3 | Wrigley Field (1-2) | 29-25 | |
| » W: Chuck Rainey (7-4) L: Bob Forsch (4-5) S: Lee Smith (9) | First | -- |
| Monday, June 13 |
| » Lost to Phillies (26-26), 6-2 | Busch Stadium II (16-10) | 29-26 | Lost 2 |
| » W: Marty Bystrom (1-3) L: Dave LaPoint (4-3) S: Willie Hernandez (2) | First | -- |
| Tuesday, June 14 |
| » Defeated Phillies (26-27), 5-4 | Busch Stadium II (17-10) | 30-26 | |
| » W: Bruce Sutter (6-3) L: Porfi Altamirano (1-2) | First | -- |
| Wednesday, June 15 |
| » Defeated Phillies (26-28), 7-6 | Busch Stadium II (18-10) | 31-26 | Won 2 |
| » W: Kevin Hagen (1-0) L: Steve Carlton (7-7) S: Bruce Sutter (5) | First | -- |
| Friday, June 17 |
| » Defeated Cubs (28-32), 7-2 | Busch Stadium II (19-10) | 32-26 | Won 3 |
| » W: Bob Forsch (5-5) L: Chuck Rainey (7-5) | First | -- |
| » Major-league debuts: Andy Van Slyke (Cardinals) |
| Saturday, June 18 |
| » Lost to Cubs (29-32), 10-1 | Busch Stadium II (19-11) | 32-27 | |
| » W: Steve Trout (6-6) L: Joaquin Andujar (3-9) | First | -- |
| Sunday, June 19 |
| » Lost to Cubs (30-32), 4-1 | Busch Stadium II (19-12) | 32-28 | Lost 2 |
| » W: Dick Ruthven (4-4) L: Dave LaPoint (4-4) | First | -- |
| Monday, June 20 |
| » Defeated Mets (23-39), 3-1 | Shea Stadium (2-0) | 33-28 | |
| » W: Kevin Hagen (2-0) L: Craig Swan (1-3) S: Bruce Sutter (6) | Second | ½ out |
| » Lost to Mets (24-39), 6-4 | Shea Stadium (2-1) | 33-29 | |
| » W: Walt Terrell (1-0) L: John Stuper (7-4) S: Jesse Orosco (6) | Second | ½ out |
| Tuesday, June 21 |
| » Defeated Mets (24-40), 6-0 | Shea Stadium (3-1) | 34-29 | |
| » W: Neil Allen (3-7) L: Tom Gorman (0-1) | First | -- |
| Wednesday, June 22 |
| » Lost to Mets (25-40), 6-4 | Shea Stadium (3-2) | 34-30 | |
| » W: Tom Seaver (5-6) L: Bob Forsch (5-6) | Second | 1½ out |
| » Lost to Mets (26-40), 2-1 | Shea Stadium (3-3) | 34-31 | Lost 2 |
| » W: Mike Torrez (4-8) L: Joaquin Andujar (3-10) S: Jesse Orosco (7) | Second | 1½ out |
| Thursday, June 23 |
| » Lost to Mets (27-40), 7-5 | Shea Stadium (3-4) | 34-32 | Lost 3 |
| » W: Carlos Diaz (2-1) L: Dave VonOhlen (1-2) S: Doug Sisk (6) | Second | 2½ out |
| Friday, June 24 |
| » Lost to Pirates (29-36), 8-2 | Busch Stadium II (19-13) | 34-33 | Lost 4 |
| » W: Jim Bibby (3-7) L: Dave LaPoint (4-5) S: Manny Sarmiento (2) | Second | 3½ out |
| Saturday, June 25 |
| » Lost to Pirates (30-36), 10-3 | Busch Stadium II (19-14) | 34-34 | Lost 5 |
| » W: Lee Tunnell (2-3) L: Kevin Hagen (2-1) | Second | 3½ out |
| Sunday, June 26 |
| » Lost to Pirates (31-36), 5-0 | Busch Stadium II (19-15) | 34-35 | Lost 6 |
| » W: Rick Rhoden (5-7) L: Neil Allen (3-8) | Second | 3½ out |
| Monday, June 27 |
| » Lost to Pirates (32-36), 6-1 | Busch Stadium II (19-16) | 34-36 | Lost 7 |
| » W: Cecilio Guante (1-0) L: Joaquin Andujar (3-11) | Second | 4½ out |
| Tuesday, June 28 |
| » Lost to Mets (29-43), 10-1 | Busch Stadium II (19-17) | 34-37 | Lost 8 |
| » W: Ed Lynch (5-3) L: Bob Forsch (5-7) | Second | 4½ out |
| » Defeated Mets (29-44), 8-1 | Busch Stadium II (20-17) | 35-37 | |
| » W: Dave LaPoint (5-5) L: Tom Gorman (0-2) | Second | 4½ out |
| Wednesday, June 29 |
| » Defeated Mets (29-45), 4-3 | Busch Stadium II (21-17) | 36-37 | Won 2 |
| » W: Bruce Sutter (7-3) L: Jesse Orosco (4-3) | Second | 4 out |
| Thursday, June 30 |
| » Defeated Mets (29-46), 6-1 | Busch Stadium II (22-17) | 37-37 | Won 3 |
| » W: Neil Allen (4-8) L: Walt Terrell (1-2) | Second | 3 out |
| Friday, July 1 |
| » Defeated Pirates (32-40), 13-6 | Three Rivers Stadium (3-0) | 38-37 | Won 4 |
| » W: Joaquin Andujar (4-11) L: Don Robinson (1-1) | Second | 2 out |
| Saturday, July 2 |
| » Lost to Pirates (33-40), 3-1 | Three Rivers Stadium (3-1) | 38-38 | |
| » W: John Candelaria (7-6) L: Dave LaPoint (5-6) | Third | 2 out |
| Sunday, July 3 |
| » Defeated Pirates (33-41), 4-3 | Three Rivers Stadium (4-1) | 39-38 | |
| » W: Bob Forsch (6-7) L: Manny Sarmiento (1-3) S: Bruce Sutter (7) | Third | 1 out |
| Monday, July 4 |
| » Lost to Pirates (34-41), 7-2 | Three Rivers Stadium (4-2) | 39-39 | |
| » W: Rick Rhoden (6-7) L: Kevin Hagen (2-2) | Third | 2 out |
| » Defeated Pirates (34-42), 11-4 | Three Rivers Stadium (5-2) | 40-39 | |
| » W: Neil Allen (5-8) L: Jim Bibby (3-9) | Third | 2 out |
| Friday, July 8 |
| » Lost to Padres (42-38), 3-2 | San Diego/Jack Murphy Stadium (1-3) | 40-40 | |
| » W: Gary Lucas (4-4) L: Bruce Sutter (7-4) | Third | 2 out |
| Saturday, July 9 |
| » Defeated Padres (42-39), 12-4 | San Diego/Jack Murphy Stadium (2-3) | 41-40 | |
| » W: Dave LaPoint (6-6) L: Dave Dravecky (12-6) | Second | 1 out |
| Sunday, July 10 |
| » Defeated Padres (42-40), 4-2 | San Diego/Jack Murphy Stadium (3-3) | 42-40 | Won 2 |
| » W: Dave VonOhlen (2-2) L: Gary Lucas (4-5) S: Bruce Sutter (8) | Second | 1 out |
| Monday, July 11 |
| » Lost to Dodgers (49-33), 7-6 | Dodger Stadium (0-4) | 42-41 | |
| » W: Joe Beckwith (1-2) L: Bruce Sutter (7-5) | Third | 1 out |
| Tuesday, July 12 |
| » Lost to Dodgers (50-33), 3-1 | Dodger Stadium (0-5) | 42-42 | Lost 2 |
| » W: Bob Welch (7-8) L: John Stuper (7-5) S: Steve Howe (10) | Third | 2 out |
| Wednesday, July 13 |
| » Defeated Dodgers (50-34), 6-5 | Dodger Stadium (1-5) | 43-42 | |
| » W: Dave Rucker (2-2) L: Steve Howe (2-4) S: Bruce Sutter (9) | Second | 2 out |
| Thursday, July 14 |
| » Defeated Giants (42-45), 6-5 | Candlestick Park (2-1) | 44-42 | Won 2 |
| » W: Dave LaPoint (7-6) L: Gary Lavelle (6-3) S: Bruce Sutter (10) | First | -- |
| Friday, July 15 |
| » Lost to Giants (43-45), 5-4 | Candlestick Park (2-2) | 44-43 | |
| » W: Jim Barr (1-1) L: Joaquin Andujar (4-12) S: Greg Minton (9) | First | -- |
| Saturday, July 16 |
| » Defeated Giants (43-46), 9-3 | Candlestick Park (3-2) | 45-43 | |
| » W: Jeff Lahti (2-1) L: Fred Breining (6-7) S: Dave VonOhlen (1) | Second | 2 out |
| Sunday, July 17 |
| » Lost to Giants (44-46), 3-1 | Candlestick Park (3-3) | 45-44 | |
| » W: Bill Laskey (11-8) L: John Stuper (7-6) | First | -- |
| Tuesday, July 19 |
| » Defeated Padres (45-45), 4-0 | Busch Stadium II (23-17) | 46-44 | |
| » W: Neil Allen (6-8) L: Tim Lollar (4-7) | First | -- |
| Wednesday, July 20 |
| » Lost to Padres (46-45), 5-4 | Busch Stadium II (23-18) | 46-45 | |
| » W: Luis DeLeon (1-3) L: Bruce Sutter (7-6) S: Sid Monge (5) | Second | 1 out |
| Thursday, July 21 |
| » Lost to Padres (47-45), 4-2 | Busch Stadium II (23-19) | 46-46 | Lost 2 |
| » W: Mark Thurmond (3-1) L: Joaquin Andujar (4-13) S: Luis DeLeon (7) | Fourth | 1 out |
| Friday, July 22 |
| » Lost to Dodgers (54-39), 9-4 | Busch Stadium II (23-20) | 46-47 | Lost 3 |
| » W: Bob Welch (8-9) L: Bob Forsch (6-8) | Fourth | 1 out |
| Saturday, July 23 |
| » Lost to Dodgers (55-39), 10-5 | Busch Stadium II (23-21) | 46-48 | Lost 4 |
| » W: Steve Howe (4-5) L: Dave Rucker (2-3) | Fourth | 2 out |
| Sunday, July 24 |
| » Defeated Dodgers (55-40), 3-0 | Busch Stadium II (24-21) | 47-48 | |
| » W: Neil Allen (7-8) L: Jerry Reuss (6-9) | Third | 1½ out |
| Monday, July 25 |
| » Defeated Giants (48-50), 9-4 | Busch Stadium II (25-21) | 48-48 | Won 2 |
| » W: Dave LaPoint (8-6) L: Andy McGaffigan (2-8) | Third | 1½ out |
| Tuesday, July 26 |
| » Defeated Giants (48-51), 6-5 | Busch Stadium II (26-21) | 49-48 | Won 3 |
| » W: Dave Rucker (3-3) L: Greg Minton (5-7) | Third | 1 out |
| Wednesday, July 27 |
| » Defeated Giants (48-52), 7-6 | Busch Stadium II (27-21) | 50-48 | Won 4 |
| » W: Dave VonOhlen (3-2) L: Jim Barr (2-2) S: Bruce Sutter (11) | Third | 1 out |
| Thursday, July 28 |
| » Defeated Expos (50-48), 3-2 | Stade Olympique (1-1) | 51-48 | Won 5 |
| » W: Bruce Sutter (8-6) L: Woodie Fryman (0-3) | Second | ½ out |
| » Defeated Expos (50-49), 10-1 | Stade Olympique (2-1) | 52-48 | Won 6 |
| » W: Bob Forsch (7-8) L: Dan Schatzeder (4-1) | Second | ½ out |
| Friday, July 29 |
| » Lost to Expos (51-49), 7-2 | Stade Olympique (2-2) | 52-49 | |
| » W: Bryn Smith (2-4) L: Neil Allen (7-9) | Second | 1½ out |
| Saturday, July 30 |
| » Defeated Expos (51-50), 3-2 | Stade Olympique (3-2) | 53-49 | |
| » W: Dave LaPoint (9-6) L: Charlie Lea (7-8) S: Bruce Sutter (12) | Second | 1½ out |
| Sunday, July 31 |
| » Lost to Expos (52-50), 6-5 | Stade Olympique (3-3) | 53-50 | |
| » W: Jeff Reardon (5-4) L: John Stuper (7-7) | Second | 1 out |
| Tuesday, August 2 |
| » Lost to Cubs (48-57), 5-3 | Busch Stadium II (27-22) | 53-51 | Lost 2 |
| » W: Dickie Noles (4-6) L: Neil Allen (7-10) S: Lee Smith (16) | Third | 2 out |
| Wednesday, August 3 |
| » Lost to Cubs (49-57), 4-0 | Busch Stadium II (27-23) | 53-52 | Lost 3 |
| » W: Chuck Rainey (11-8) L: Bob Forsch (7-9) S: Bill Campbell (7) | Third | 3 out |
| Thursday, August 4 |
| » Lost to Cubs (50-57), 9-6 | Busch Stadium II (27-24) | 53-53 | Lost 4 |
| » W: Steve Trout (9-9) L: Dave LaPoint (9-7) S: Lee Smith (17) | Fourth | 3 out |
| Friday, August 5 |
| » Lost to Phillies (54-50), 10-7 | Busch Stadium II (27-25) | 53-54 | Lost 5 |
| » W: John Denny (12-5) L: John Stuper (7-8) S: Ron Reed (4) | Fourth | 3 out |
| Saturday, August 6 |
| » Lost to Phillies (55-50), 1-0 | Busch Stadium II (27-26) | 53-55 | Lost 6 |
| » W: Al Holland (6-0) L: Bruce Sutter (8-7) | Fourth | 3½ out |
| » Major-league debuts: Danny Cox (Cardinals) |
| Sunday, August 7 |
| » Lost to Phillies (56-50), 5-2 | Busch Stadium II (27-27) | 53-56 | Lost 7 |
| » W: Marty Bystrom (4-7) L: Neil Allen (7-11) S: Ron Reed (5) | Fourth | 4½ out |
| Tuesday, August 9 |
| » Lost to Cubs (51-60), 5-3 | Wrigley Field (1-3) | 53-57 | Lost 8 |
| » W: Chuck Rainey (12-8) L: Bob Forsch (7-10) S: Lee Smith (18) | Fourth | 5 out |
| Wednesday, August 10 |
| » Defeated Cubs (51-61), 9-5 | Wrigley Field (2-3) | 54-57 | |
| » W: Dave Rucker (4-3) L: Dickie Noles (4-7) S: John Stuper (1) | Fourth | 5 out |
| Thursday, August 11 |
| » Lost to Cubs (52-61), 10-5 | Wrigley Field (2-4) | 54-58 | |
| » W: Dick Ruthven (8-9) L: Danny Cox (0-1) | Fourth | 5½ out |
| Friday, August 12 |
| » Lost to Phillies (59-51), 5-2 | Veteran's Stadium (1-3) | 54-59 | Lost 2 |
| » W: Marty Bystrom (5-7) L: Neil Allen (7-12) S: Willie Hernandez (8) | Fourth | 6½ out |
| Saturday, August 13 |
| » Defeated Phillies (59-52), 6-2 | Veteran's Stadium (2-3) | 55-59 | |
| » W: Dave LaPoint (10-7) L: Charles Hudson (7-4) | Fourth | 5½ out |
| Sunday, August 14 |
| » Lost to Phillies (60-52), 5-1 | Veteran's Stadium (2-4) | 55-60 | |
| » W: John Denny (13-5) L: Bob Forsch (7-11) | Fourth | 6½ out |
| Monday, August 15 |
| » Lost to Expos (59-56), 5-1 | Busch Stadium II (27-28) | 55-61 | Lost 2 |
| » W: Charlie Lea (10-8) L: Bruce Sutter (8-8) S: Jeff Reardon (18) | Fourth | 7½ out |
| Tuesday, August 16 |
| » Defeated Expos (59-57), 4-3 | Busch Stadium II (28-28) | 56-61 | |
| » W: Neil Allen (8-12) L: Jeff Reardon (5-7) | Fourth | 7 out |
| Thursday, August 18 |
| » Defeated Astros (63-56), 5-4 | Busch Stadium II (29-28) | 57-61 | Won 2 |
| » W: Dave Rucker (5-3) L: Bill Dawley (5-5) | Fourth | 6½ out |
| Friday, August 19 |
| » Defeated Astros (63-57), 2-0 | Busch Stadium II (30-28) | 58-61 | Won 3 |
| » W: Dave LaPoint (11-7) L: Mike Madden (5-2) S: Bruce Sutter (13) | Fourth | 5½ out |
| Saturday, August 20 |
| » Defeated Astros (63-58), 3-0 | Busch Stadium II (31-28) | 59-61 | Won 4 |
| » W: John Stuper (8-8) L: Bob Knepper (5-12) | Fourth | 4½ out |
| Sunday, August 21 |
| » Defeated Astros (63-59), 5-2 | Busch Stadium II (32-28) | 60-61 | Won 5 |
| » W: Danny Cox (1-1) L: Nolan Ryan (12-6) S: Bruce Sutter (14) | Fourth | 3½ out |
| Tuesday, August 23 |
| » Defeated Braves (74-51), 7-0 | Busch Stadium II (33-28) | 61-61 | Won 6 |
| » W: Joaquin Andujar (5-13) L: Pete Falcone (8-3) | Third | 2 out |
| Wednesday, August 24 |
| » Lost to Braves (75-51), 11-3 | Busch Stadium II (33-29) | 61-62 | |
| » W: Phil Niekro (10-7) L: Dave LaPoint (11-8) | Third | 2 out |
| Thursday, August 25 |
| » Defeated Braves (75-52), 2-1 | Busch Stadium II (34-29) | 62-62 | |
| » W: Neil Allen (9-12) L: Steve Bedrosian (8-7) | Third | 1½ out |
| Friday, August 26 |
| » Lost to Reds (59-70), 7-3 | Riverfront Stadium (2-2) | 62-63 | |
| » W: Charlie Puleo (5-9) L: Danny Cox (1-2) S: Bill Scherrer (9) | Third | 2½ out |
| Saturday, August 27 |
| » Defeated Reds (59-71), 3-1 | Riverfront Stadium (3-2) | 63-63 | |
| » W: Dave Rucker (6-3) L: Ted Power (5-6) S: Bruce Sutter (15) | Third | 2½ out |
| Sunday, August 28 |
| » Lost to Reds (60-71), 5-4 | Riverfront Stadium (3-3) | 63-64 | |
| » W: Ben Hayes (4-2) L: Bruce Sutter (8-9) | Fourth | 2½ out |
| Monday, August 29 |
| » Defeated Astros (68-62), 6-1 | Astrodome (4-1) | 64-64 | |
| » W: John Stuper (9-8) L: Mike Madden (6-3) | Third | 2½ out |
| Tuesday, August 30 |
| » Lost to Astros (69-62), 3-1 | Astrodome (4-2) | 64-65 | |
| » W: Vern Ruhle (8-3) L: Danny Cox (1-3) S: Bill Dawley (14) | Fourth | 3½ out |
| Wednesday, August 31 |
| » Defeated Braves (76-57), 6-3 | Atlanta-Fulton County Stadium (2-3) | 65-65 | |
| » W: Joaquin Andujar (6-13) L: Len Barker (8-14) S: Bruce Sutter (16) | Fourth | 2½ out |
| Thursday, September 1 |
| » Defeated Braves (76-58), 8-3 | Atlanta-Fulton County Stadium (3-3) | 66-65 | Won 2 |
| » W: Bob Forsch (8-11) L: Pascual Perez (13-6) | Third | 1½ out |
| Friday, September 2 |
| » Lost to Reds (62-74), 4-0 | Busch Stadium II (34-30) | 66-66 | |
| » W: Frank Pastore (7-12) L: John Stuper (9-9) | Third | 2½ out |
| Saturday, September 3 |
| » Lost to Reds (63-74), 3-2 | Busch Stadium II (34-31) | 66-67 | Lost 2 |
| » W: Mario Soto (15-11) L: Dave Rucker (6-4) | Fourth | 3½ out |
| Sunday, September 4 |
| » Defeated Reds (63-75), 5-4 | Busch Stadium II (35-31) | 67-67 | |
| » W: Jeff Lahti (3-1) L: Ben Hayes (4-3) | Fourth | 2½ out |
| Monday, September 5 |
| » Defeated Pirates (70-66), 7-4 | Busch Stadium II (36-31) | 68-67 | Won 2 |
| » W: Dave LaPoint (12-8) L: Rod Scurry (4-9) | Third | ½ out |
| » Defeated Pirates (70-67), 7-6 | Busch Stadium II (37-31) | 69-67 | Won 3 |
| » W: Neil Allen (10-12) L: Cecilio Guante (2-3) | Third | ½ out |
| Tuesday, September 6 |
| » Lost to Pirates (71-67), 5-0 | Busch Stadium II (37-32) | 69-68 | |
| » W: Lee Tunnell (8-5) L: John Stuper (9-10) | Fourth | 1½ out |
| Wednesday, September 7 |
| » Defeated Pirates (71-68), 5-2 | Busch Stadium II (38-32) | 70-68 | |
| » W: Danny Cox (2-3) L: Rick Rhoden (10-12) S: Bruce Sutter (17) | Fourth | 1½ out |
| Friday, September 9 |
| » Defeated Cubs (62-78), 6-5 | Wrigley Field (3-4) | 71-68 | Won 2 |
| » W: Bruce Sutter (9-9) L: Lee Smith (4-8) | Third | 1 out |
| » Major-league debuts: Fritzie Connally (Cubs) |
| Saturday, September 10 |
| » Lost to Cubs (63-78), 8-5 | Wrigley Field (3-5) | 71-69 | |
| » W: Bill Campbell (5-8) L: Jeff Lahti (3-2) S: Lee Smith (25) | Fourth | 1½ out |
| Sunday, September 11 |
| » Defeated Cubs (63-79), 2-1 | Wrigley Field (4-5) | 72-69 | |
| » W: John Stuper (10-10) L: Lee Smith (4-9) S: Bruce Sutter (18) | Third | 1½ out |
| Monday, September 12 |
| » Lost to Pirates (73-70), 7-5 | Three Rivers Stadium (5-3) | 72-70 | |
| » W: Lee Tunnell (9-5) L: Danny Cox (2-4) S: Manny Sarmiento (4) | Fourth | 2 out |
| Tuesday, September 13 |
| » Lost to Pirates (74-70), 6-0 | Three Rivers Stadium (5-4) | 72-71 | Lost 2 |
| » W: Rick Rhoden (11-12) L: Joaquin Andujar (6-14) | Fourth | 2½ out |
| Wednesday, September 14 |
| » Defeated Mets (60-85), 2-1 | Shea Stadium (4-4) | 73-71 | |
| » W: Neil Allen (11-12) L: Tom Seaver (8-14) S: Bruce Sutter (19) | Fourth | 2½ out |
| Thursday, September 15 |
| » Lost to Mets (61-85), 6-4 | Shea Stadium (4-5) | 73-72 | |
| » W: Ed Lynch (10-9) L: Dave LaPoint (12-9) S: Jesse Orosco (17) | Third | 2½ out |
| Friday, September 16 |
| » Lost to Phillies (77-70), 3-2 | Veteran's Stadium (2-5) | 73-73 | Lost 2 |
| » W: Willie Hernandez (7-4) L: Steve Baker (3-4) | Third | 3½ out |
| Saturday, September 17 |
| » Lost to Phillies (78-70), 4-1 | Veteran's Stadium (2-6) | 73-74 | Lost 3 |
| » W: John Denny (16-6) L: Danny Cox (2-5) S: Al Holland (20) | Third | 4½ out |
| Sunday, September 18 |
| » Lost to Phillies (79-70), 5-3 | Veteran's Stadium (2-7) | 73-75 | Lost 4 |
| » W: Steve Carlton (14-15) L: Joaquin Andujar (6-15) S: Al Holland (21) | Fourth | 5½ out |
| Monday, September 19 |
| » Lost to Expos (77-72), 3-0 | Stade Olympique (3-4) | 73-76 | Lost 5 |
| » W: Bryn Smith (5-10) L: Neil Allen (11-13) | Third | 7 out |
| » Lost to Expos (78-72), 6-3 | Stade Olympique (3-5) |
