| Wednesday, March 16 |
| Future Blue Jay Brandon League is born in Honolulu, HI. |
| Tuesday, April 5 |
| » Defeated Red Sox (0-1), 7-1 | Fenway Park (1-0) | 1-0 | |
| » W: Dave Stieb (1-0) L: Dennis Eckersley (0-1) S: Roy Lee Jackson (1) | First | -- |
| Thursday, April 7 |
| » Lost to Red Sox (1-1), 7-4 | Fenway Park (1-1) | 1-1 | |
| » W: Bob Stanley (1-0) L: Luis Leal (0-1) | Second | ½ out |
| » Major-league debuts: Jim Acker (Blue Jays) |
| Saturday, April 9 |
| » Defeated Yankees (1-3), 7-4 | Exhibition Stadium (1-0) | 2-1 | |
| » W: Roy Lee Jackson (1-0) L: Rich Gossage (0-1) | Second | ½ out |
| Sunday, April 10 |
| » Lost to Yankees (2-3), 3-0 | Exhibition Stadium (1-1) | 2-2 | |
| » W: Shane Rawley (1-0) L: Dave Stieb (1-1) | Second | ½ out |
| Tuesday, April 12 |
| » Lost to Brewers (3-3), 6-5 | Exhibition Stadium (1-2) | 2-3 | Lost 2 |
| » W: Don Sutton (1-1) L: Mike Morgan (0-1) S: Jamie Easterly (1) | Third | 1 out |
| Wednesday, April 13 |
| » Defeated Brewers (3-4), 7-2 | Exhibition Stadium (2-2) | 3-3 | |
| » W: Jim Clancy (1-0) L: Mike Caldwell (0-2) | Third | ½ out |
| » Major-league debuts: Bob Gibson (Brewers) |
| Thursday, April 14 |
| » Lost to Brewers (4-4), 5-4 | Exhibition Stadium (2-3) | 3-4 | |
| » W: Jim Slaton (1-0) L: Joey McLaughlin (0-1) | Fourth | 1 out |
| Friday, April 15 |
| » Defeated Yankees (3-6), 6-5 | Yankee Stadium (1-0) | 4-4 | |
| » W: Dave Stieb (2-1) L: Rudy May (0-1) | Fourth | ½ out |
| Sunday, April 17 |
| » Lost to Yankees (4-6), 7-5 | Yankee Stadium (1-1) | 4-5 | |
| » W: Shane Rawley (2-0) L: Jim Clancy (1-1) | Fourth | 1 out |
| Monday, April 18 |
| » Lost to Yankees (5-6), 3-0 | Yankee Stadium (1-2) | 4-6 | Lost 2 |
| » W: Ron Guidry (1-1) L: Luis Leal (0-2) | Fifth | 2 out |
| Tuesday, April 19 |
| » Defeated Indians (5-7), 9-7 | Exhibition Stadium (3-3) | 5-6 | |
| » W: Randy Moffitt (1-0) L: Dan Spillner (0-1) | Third | 2 out |
| Wednesday, April 20 |
| » Defeated Indians (5-8), 4-1 | Exhibition Stadium (4-3) | 6-6 | Won 2 |
| » W: Dave Stieb (3-1) L: Lary Sorensen (0-3) | Second | 1 out |
| Friday, April 22 |
| » Lost to Royals (7-4), 6-5 | Royals Stadium (0-1) | 6-7 | |
| » W: Dennis Leonard (2-1) L: Roy Lee Jackson (1-1) S: Dan Quisenberry (4) | Third | 1½ out |
| Saturday, April 23 |
| » Defeated Royals (7-5), 5-4 | Royals Stadium (1-1) | 7-7 | |
| » W: Randy Moffitt (2-0) L: Dan Quisenberry (1-1) S: Joey McLaughlin (1) | Second | 1½ out |
| Sunday, April 24 |
| » Lost to Royals (8-5), 7-1 | Royals Stadium (1-2) | 7-8 | |
| » W: Steve Renko (1-1) L: Jim Gott (0-1) | Third | 1½ out |
| Tuesday, April 26 |
| » Lost to Rangers (10-8), 2-1 | Arlington Stadium (0-1) | 7-9 | Lost 2 |
| » W: Mike Smithson (3-0) L: Dave Stieb (3-2) | Sixth | 2 out |
| Wednesday, April 27 |
| » Defeated Rangers (10-9), 3-2 | Arlington Stadium (1-1) | 8-9 | |
| » W: Randy Moffitt (3-0) L: Danny Darwin (1-2) | Sixth | 2 out |
| Friday, April 29 |
| » Lost to White Sox (8-10), 9-3 | Exhibition Stadium (4-4) | 8-10 | |
| » W: Richard Dotson (3-1) L: Luis Leal (0-3) S: Dick Tidrow (2) | Fifth | 2½ out |
| Sunday, May 1 |
| » Defeated White Sox (8-11), 8-0 | Exhibition Stadium (5-4) | 9-10 | |
| » W: Dave Stieb (4-2) L: Floyd Bannister (1-4) | Fourth | 2 out |
| Monday, May 2 |
| » Defeated Rangers (12-11), 6-5 | Exhibition Stadium (6-4) | 10-10 | Won 2 |
| » W: Jim Clancy (2-1) L: Danny Darwin (1-3) S: Randy Moffitt (1) | Third | 1½ out |
| Tuesday, May 3 |
| » Lost to Rangers (13-11), 7-2 | Exhibition Stadium (6-5) | 10-11 | |
| » W: Jon Matlack (2-1) L: Jim Gott (0-2) S: Dave Tobik (3) | Fifth | 2½ out |
| Wednesday, May 4 |
| » Defeated Rangers (13-12), 7-1 | Exhibition Stadium (7-5) | 11-11 | |
| » W: Luis Leal (1-3) L: Rick Honeycutt (3-2) | Fourth | 2 out |
| Friday, May 6 |
| » Defeated Royals (12-10), 6-1 | Exhibition Stadium (8-5) | 12-11 | Won 2 |
| » W: Dave Stieb (5-2) L: Larry Gura (4-2) | Third | 2 out |
| Saturday, May 7 |
| » Defeated Royals (12-11), 7-4 | Exhibition Stadium (9-5) | 13-11 | Won 3 |
| » W: Roy Lee Jackson (2-1) L: Dennis Leonard (3-3) S: Randy Moffitt (2) | Third | 2 out |
| Sunday, May 8 |
| » Lost to Royals (13-11), 6-1 | Exhibition Stadium (9-6) | 13-12 | |
| » W: Steve Renko (2-2) L: Jim Gott (0-3) S: Dan Quisenberry (7) | Third | 2 out |
| Monday, May 9 |
| » Defeated White Sox (12-14), 6-1 | Comiskey Park I (1-0) | 14-12 | |
| » W: Luis Leal (2-3) L: Britt Burns (0-1) | Third | 2 out |
| Wednesday, May 11 |
| » Defeated White Sox (12-15), 3-1 | Comiskey Park I (2-0) | 15-12 | Won 2 |
| » W: Dave Stieb (6-2) L: La Marr Hoyt (2-5) | Third | 1 out |
| Thursday, May 12 |
| » Defeated Indians (16-14), 6-3 | Cleveland Stadium (1-0) | 16-12 | Won 3 |
| » W: Jim Clancy (3-1) L: Lary Sorensen (2-5) S: Randy Moffitt (3) | Second | ½ out |
| Friday, May 13 |
| » Lost to Indians (17-14), 5-1 | Cleveland Stadium (1-1) | 16-13 | |
| » W: Juan Eichelberger (1-1) L: Mike Morgan (0-2) | Third | 1½ out |
| Saturday, May 14 |
| » Defeated Indians (17-15), 8-1 | Cleveland Stadium (2-1) | 17-13 | |
| » W: Luis Leal (3-3) L: Bert Blyleven (3-4) S: Roy Lee Jackson (2) | Second | 1½ out |
| Monday, May 16 |
| » Defeated Brewers (16-15), 2-1 | County Stadium (1-0) | 18-13 | Won 2 |
| » W: Dave Stieb (7-2) L: Bob McClure (1-6) S: Randy Moffitt (4) | Second | ½ out |
| Tuesday, May 17 |
| » Lost to Brewers (17-15), 9-6 | County Stadium (1-1) | 18-14 | |
| » W: Mike Caldwell (3-4) L: Jim Clancy (3-2) S: Tom Tellmann (2) | Third | 2 out |
| Wednesday, May 18 |
| » Lost to Brewers (18-15), 7-6 | County Stadium (1-2) | 18-15 | Lost 2 |
| » W: Jim Slaton (5-0) L: Dave Geisel (0-1) | Third | 3 out |
| Thursday, May 19 |
| » Lost to Orioles (23-13), 2-1 | Exhibition Stadium (9-7) | 18-16 | Lost 3 |
| » W: Scott McGregor (4-2) L: Mike Morgan (0-3) S: Tippy Martinez (4) | Fourth | 4 out |
| Friday, May 20 |
| » Defeated Orioles (23-14), 7-5 | Exhibition Stadium (10-7) | 19-16 | |
| » W: Jim Gott (1-3) L: Dennis Martinez (3-7) S: Joey McLaughlin (2) | Fourth | 3 out |
| Saturday, May 21 |
| » Defeated Orioles (23-15), 6-0 | Exhibition Stadium (11-7) | 20-16 | Won 2 |
| » W: Dave Stieb (8-2) L: Sammy Stewart (2-2) | Third | 2 out |
| Sunday, May 22 |
| » Defeated Orioles (23-16), 5-0 | Exhibition Stadium (12-7) | 21-16 | Won 3 |
| » W: Jim Clancy (4-2) L: Mike Boddicker (1-1) | Second | 1 out |
| Monday, May 23 |
| » Defeated Tigers (17-21), 4-0 | Exhibition Stadium (13-7) | 22-16 | Won 4 |
| » W: Luis Leal (4-3) L: Milt Wilcox (4-5) S: Randy Moffitt (5) | First | -- |
| Tuesday, May 24 |
| » Defeated Tigers (17-22), 7-6 | Exhibition Stadium (14-7) | 23-16 | Won 5 |
| » W: Roy Lee Jackson (3-1) L: Dave Rucker (1-2) S: Joey McLaughlin (3) | First | -- |
| Wednesday, May 25 |
| » Lost to Tigers (18-22), 6-2 | Exhibition Stadium (14-8) | 23-17 | |
| » W: Dan Petry (5-2) L: Jim Gott (1-4) S: Aurelio Lopez (5) | First | -- |
| Thursday, May 26 |
| » Lost to Red Sox (24-17), 7-2 | Exhibition Stadium (14-9) | 23-18 | Lost 2 |
| » W: Bob Stanley (4-2) L: Dave Stieb (8-3) | Second | 1 out |
| Friday, May 27 |
| » Lost to Red Sox (25-17), 2-0 | Exhibition Stadium (14-10) | 23-19 | Lost 3 |
| » W: John Tudor (3-2) L: Jim Clancy (4-3) | Second | 2 out |
| Saturday, May 28 |
| » Defeated Red Sox (25-18), 9-5 | Exhibition Stadium (15-10) | 24-19 | |
| » W: Roy Lee Jackson (4-1) L: Luis Aponte (3-3) S: Joey McLaughlin (4) | Second | 1 out |
| Sunday, May 29 |
| » Defeated Red Sox (25-19), 6-1 | Exhibition Stadium (16-10) | 25-19 | Won 2 |
| » W: Jim Gott (2-4) L: Dennis Eckersley (3-2) | First | -- |
| Monday, May 30 |
| » Defeated Tigers (22-23), 6-4 | Tiger Stadium (1-0) | 26-19 | Won 3 |
| » W: Joey McLaughlin (1-1) L: Dave Gumpert (0-1) | First | -- |
| Wednesday, June 1 |
| » Lost to Tigers (23-23), 3-1 | Tiger Stadium (1-1) | 26-20 | |
| » W: Dave Rozema (2-0) L: Jim Clancy (4-4) S: Aurelio Lopez (7) | First | -- |
| Thursday, June 2 |
| » Defeated Tigers (23-24), 6-1 | Tiger Stadium (2-1) | 27-20 | |
| » W: Luis Leal (5-3) L: Milt Wilcox (5-6) | First | -- |
| Friday, June 3 |
| » Lost to Orioles (28-22), 3-2 | Memorial Stadium (0-1) | 27-21 | |
| » W: Tippy Martinez (3-1) L: Joey McLaughlin (1-2) | First | -- |
| Saturday, June 4 |
| » Lost to Orioles (29-22), 6-4 | Memorial Stadium (0-2) | 27-22 | Lost 2 |
| » W: Mike Boddicker (3-2) L: Dave Stieb (8-4) S: Sammy Stewart (2) | Third | 1 out |
| Sunday, June 5 |
| » Defeated Orioles (29-23), 5-2 | Memorial Stadium (1-2) | 28-22 | |
| » W: Jim Clancy (5-4) L: Storm Davis (3-3) S: Joey McLaughlin (5) | First | -- |
| Monday, June 6 |
| » Lost to Orioles (30-23), 8-1 | Memorial Stadium (1-3) | 28-23 | |
| » W: Scott McGregor (7-3) L: Luis Leal (5-4) | Second | 1 out |
| Tuesday, June 7 |
| » Lost to Athletics (27-26), 5-3 | Oakland-Alameda County Stadium (0-1) | 28-24 | Lost 2 |
| » W: Tim Conroy (1-1) L: Jim Gott (2-5) S: Steve Baker (3) | Second | 2 out |
| Wednesday, June 8 |
| » Defeated Athletics (27-27), 5-2 | Oakland-Alameda County Stadium (1-1) | 29-24 | |
| » W: Dave Stieb (9-4) L: Chris Codiroli (4-5) S: Joey McLaughlin (6) | Second | 2 out |
| Thursday, June 9 |
| » Lost to Athletics (28-27), 3-1 | Oakland-Alameda County Stadium (1-2) | 29-25 | |
| » W: Tom Underwood (4-2) L: Jim Clancy (5-5) S: Steve Baker (4) | Second | 3 out |
| Friday, June 10 |
| » Lost to Angels (33-24), 5-3 | Anaheim Stadium (0-1) | 29-26 | Lost 2 |
| » W: Curt Brown (1-0) L: Luis Leal (5-5) | Third | 4 out |
| Saturday, June 11 |
| » Defeated Angels (33-25), 3-2 | Anaheim Stadium (1-1) | 30-26 | |
| » W: Jim Gott (3-5) L: Dave Goltz (0-5) S: Randy Moffitt (6) | Second | 4 out |
| Sunday, June 12 |
| » Defeated Angels (33-26), 6-5 | Anaheim Stadium (2-1) | 31-26 | Won 2 |
| » W: Stan Clarke (1-0) L: Curt Brown (1-1) S: Dave Geisel (1) | Third | 3 out |
| Tuesday, June 14 |
| » Defeated Athletics (30-30), 13-7 | Exhibition Stadium (17-10) | 32-26 | Won 3 |
| » W: Roy Lee Jackson (5-1) L: Tom Underwood (4-3) | Second | 3 out |
| Wednesday, June 15 |
| » Lost to Athletics (31-30), 10-1 | Exhibition Stadium (17-11) | 32-27 | |
| » W: Bill Krueger (5-5) L: Luis Leal (5-6) | Third | 4 out |
| Thursday, June 16 |
| » Defeated Athletics (31-31), 9-1 | Exhibition Stadium (18-11) | 33-27 | |
| » W: Jim Gott (4-5) L: Steve McCatty (1-1) | Third | 3 out |
| Friday, June 17 |
| » Defeated Angels (34-28), 6-3 | Exhibition Stadium (19-11) | 34-27 | Won 2 |
| » W: Dave Stieb (10-4) L: Bill Travers (0-2) | Third | 2 out |
| Saturday, June 18 |
| » Lost to Angels (35-28), 7-6 | Exhibition Stadium (19-12) | 34-28 | |
| » W: Luis Sanchez (7-2) L: Stan Clarke (1-1) | Third | 2 out |
| Sunday, June 19 |
| » Defeated Angels (35-29), 6-1 | Exhibition Stadium (20-12) | 35-28 | |
| » W: Luis Leal (6-6) L: Dave Goltz (0-6) | Second | 2 out |
| Monday, June 20 |
| » Defeated Twins (28-40), 2-1 | Exhibition Stadium (21-12) | 36-28 | Won 2 |
| » W: Jim Gott (5-5) L: Ron Davis (2-3) | Second | 1½ out |
| Tuesday, June 21 |
| » Defeated Twins (28-41), 8-3 | Exhibition Stadium (22-12) | 37-28 | Won 3 |
| » W: Jim Acker (1-0) L: Bryan Oelkers (0-4) | Second | 1½ out |
| Wednesday, June 22 |
| » Lost to Twins (29-41), 4-3 | Exhibition Stadium (22-13) | 37-29 | |
| » W: Ken Schrom (5-2) L: Dave Stieb (10-5) S: Ron Davis (10) | Second | 1½ out |
| Thursday, June 23 |
| » Defeated Mariners (26-46), 5-4 | Kingdome (1-0) | 38-29 | |
| » W: Jim Clancy (6-5) L: Mike Stanton (0-1) S: Joey McLaughlin (7) | Second | 1 out |
| Friday, June 24 |
| » Defeated Mariners (26-47), 4-2 | Kingdome (2-0) | 39-29 | Won 2 |
| » W: Luis Leal (7-6) L: Matt Young (7-7) | First | -- |
| Saturday, June 25 |
| » Lost to Mariners (27-47), 5-2 | Kingdome (2-1) | 39-30 | |
| » W: Jim Beattie (5-5) L: Jim Gott (5-6) S: Bill Caudill (14) | First | -- |
| » Major-league debuts: Spike Owen (Mariners) |
| Sunday, June 26 |
| » Defeated Mariners (27-48), 19-7 | Kingdome (3-1) | 40-30 | |
| » W: Jim Acker (2-0) L: Bob Stoddard (4-10) | First | -- |
| Tuesday, June 28 |
| » Lost to Twins (31-44), 5-2 | Hubert H. Humphrey Metrodome (0-1) | 40-31 | |
| » W: Ken Schrom (6-2) L: Dave Stieb (10-6) S: Ron Davis (11) | First | -- |
| Wednesday, June 29 |
| » Defeated Twins (31-45), 4-2 | Hubert H. Humphrey Metrodome (1-1) | 41-31 | |
| » W: Jim Clancy (7-5) L: Bobby Castillo (4-6) | First | -- |
| Thursday, June 30 |
| » Defeated Twins (31-46), 11-3 | Hubert H. Humphrey Metrodome (2-1) | 42-31 | Won 2 |
| » W: Luis Leal (8-6) L: Albert Williams (4-9) | First | -- |
| Friday, July 1 |
| » Lost to Mariners (29-50), 11-2 | Exhibition Stadium (22-14) | 42-32 | |
| » W: Jim Beattie (6-5) L: Jim Gott (5-7) | First | -- |
| Saturday, July 2 |
| » Defeated Mariners (29-51), 7-6 | Exhibition Stadium (23-14) | 43-32 | |
| » W: Roy Lee Jackson (6-1) L: Bill Caudill (1-5) | First | -- |
| Sunday, July 3 |
| » Lost to Mariners (30-51), 4-1 | Exhibition Stadium (23-15) | 43-33 | |
| » W: Glenn Abbott (3-0) L: Dave Stieb (10-7) | First | -- |
| Friday, July 8 |
| » Defeated Rangers (44-35), 8-5 | Exhibition Stadium (24-15) | 44-33 | |
| » W: Jim Clancy (8-5) L: Danny Darwin (7-7) S: Randy Moffitt (7) | First | -- |
| Saturday, July 9 |
| » Defeated Rangers (44-36), 5-1 | Exhibition Stadium (25-15) | 45-33 | Won 2 |
| » W: Luis Leal (9-6) L: Charlie Hough (7-7) | First | -- |
| Sunday, July 10 |
| » Defeated Rangers (44-37), 6-4 | Exhibition Stadium (26-15) | 46-33 | Won 3 |
| » W: Dave Stieb (11-7) L: Rick Honeycutt (11-5) S: Randy Moffitt (8) | First | -- |
| Monday, July 11 |
| » Defeated Royals (38-39), 7-4 | Royals Stadium (2-2) | 47-33 | Won 4 |
| » W: Randy Moffitt (4-0) L: Keith Creel (0-4) | First | -- |
| Tuesday, July 12 |
| » Defeated Royals (38-40), 9-6 | Royals Stadium (3-2) | 48-33 | Won 5 |
| » W: Roy Lee Jackson (7-1) L: Steve Renko (5-7) | First | -- |
| Wednesday, July 13 |
| » Lost to Royals (39-40), 5-4 | Royals Stadium (3-3) | 48-34 | |
| » W: Larry Gura (8-10) L: Jim Clancy (8-6) S: Dan Quisenberry (21) | First | -- |
| Thursday, July 14 |
| » Defeated White Sox (44-40), 8-0 | Comiskey Park I (3-0) | 49-34 | |
| » W: Luis Leal (10-6) L: Jerry Koosman (7-2) | First | -- |
| Friday, July 15 |
| » Defeated White Sox (44-41), 3-2 | Comiskey Park I (4-0) | 50-34 | Won 2 |
| » W: Joey McLaughlin (2-2) L: Richard Dotson (8-6) | First | -- |
| Saturday, July 16 |
| » Defeated White Sox (44-42), 7-5 | Comiskey Park I (5-0) | 51-34 | Won 3 |
| » W: Joey McLaughlin (3-2) L: Juan Agosto (1-1) S: Randy Moffitt (9) | First | -- |
| Sunday, July 17 |
| » Lost to White Sox (45-42), 3-2 | Comiskey Park I (5-1) | 51-35 | |
| » W: Floyd Bannister (5-9) L: Doyle Alexander (0-3) S: Dennis Lamp (2) | First | -- |
| Monday, July 18 |
| » Defeated Royals (41-43), 8-2 | Exhibition Stadium (27-15) | 52-35 | |
| » W: Jim Clancy (9-6) L: Larry Gura (8-11) | First | -- |
| Tuesday, July 19 |
| » Lost to Royals (42-43), 6-2 | Exhibition Stadium (27-16) | 52-36 | |
| » W: Bud Black (4-3) L: Luis Leal (10-7) S: Dan Quisenberry (22) | First | -- |
| Wednesday, July 20 |
| » Lost to Royals (43-43), 14-8 | Exhibition Stadium (27-17) | 52-37 | Lost 2 |
| » W: Paul Splittorff (8-3) L: Dave Stieb (11-8) S: Dan Quisenberry (23) | First | -- |
| Thursday, July 21 |
| » Lost to Rangers (48-45), 3-2 | Arlington Stadium (1-2) | 52-38 | Lost 3 |
| » W: Frank Tanana (4-2) L: Jim Gott (5-8) | First | -- |
| Friday, July 22 |
| » Defeated Rangers (48-46), 10-5 | Arlington Stadium (2-2) | 53-38 | |
| » W: Randy Moffitt (5-0) L: Dave Schmidt (2-1) | First | -- |
| Saturday, July 23 |
| » Defeated Rangers (48-47), 3-2 | Arlington Stadium (3-2) | 54-38 | Won 2 |
| » W: Jim Clancy (10-6) L: Danny Darwin (7-10) | First | -- |
| Sunday, July 24 |
| » Lost to Rangers (49-47), 3-0 | Arlington Stadium (3-3) | 54-39 | |
| » W: Rick Honeycutt (13-6) L: Luis Leal (10-8) | First | -- |
| Monday, July 25 |
| » Lost to White Sox (49-46), 7-4 | Exhibition Stadium (27-18) | 54-40 | Lost 2 |
| » W: Richard Dotson (10-6) L: Dave Stieb (11-9) S: Dennis Lamp (4) | First | -- |
| Tuesday, July 26 |
| » Defeated White Sox (49-47), 6-4 | Exhibition Stadium (28-18) | 55-40 | |
| » W: Jim Gott (6-8) L: Britt Burns (5-6) S: Joey McLaughlin (8) | Third | ½ out |
| » Lost to White Sox (50-47), 4-3 | Exhibition Stadium (28-19) | 55-41 | |
| » W: Floyd Bannister (7-9) L: Doyle Alexander (0-4) S: Dennis Lamp (5) | Third | ½ out |
| Wednesday, July 27 |
| » Lost to White Sox (51-47), 11-3 | Exhibition Stadium (28-20) | 55-42 | Lost 2 |
| » W: La Marr Hoyt (12-10) L: Luis Leal (10-9) | Fourth | 1½ out |
| Friday, July 29 |
| » Defeated Indians (40-59), 4-2 | Exhibition Stadium (29-20) | 56-42 | |
| » W: Jim Clancy (11-6) L: Rick Sutcliffe (12-6) | Fourth | 1½ out |
| Saturday, July 30 |
| » Defeated Indians (40-60), 6-5 | Exhibition Stadium (30-20) | 57-42 | Won 2 |
| » W: Joey McLaughlin (4-2) L: Bud Anderson (0-2) | Third | 1½ out |
| » Major-league debuts: Joe Carter (Indians) |
| Sunday, July 31 |
| » Lost to Indians (41-60), 16-11 | Exhibition Stadium (30-21) | 57-43 | |
| » W: Juan Eichelberger (4-10) L: Jim Acker (2-1) S: Bud Anderson (2) | Fourth | 2½ out |
| Monday, August 1 |
| » Lost to Indians (42-60), 6-0 | Exhibition Stadium (30-22) | 57-44 | Lost 2 |
| » W: Len Barker (8-11) L: Doyle Alexander (0-5) | Fourth | 3 out |
| Tuesday, August 2 |
| » Defeated Yankees (56-44), 10-9 | Exhibition Stadium (31-22) | 58-44 | |
| » W: Roy Lee Jackson (8-1) L: Dale Murray (2-2) | Third | 1 out |
| » Defeated Yankees (56-45), 13-6 | Exhibition Stadium (32-22) | 59-44 | Won 2 |
| » W: Matt Williams (1-0) L: Bob Shirley (3-6) S: Dave Geisel (2) | Third | 1 out |
| » Major-league debuts: Matt Williams (Blue Jays) |
| Wednesday, August 3 |
| » Defeated Yankees (56-46), 6-2 | Exhibition Stadium (33-22) | 60-44 | Won 3 |
| » W: Jim Clancy (12-6) L: Ron Guidry (12-7) | Third | 1 out |
| Thursday, August 4 |
| » Lost to Yankees (57-46), 3-1 | Exhibition Stadium (33-23) | 60-45 | |
| » W: Shane Rawley (10-9) L: Dave Stieb (11-10) | Third | 2 out |
| Friday, August 5 |
| » Lost to Brewers (59-46), 7-0 | County Stadium (1-3) | 60-46 | Lost 2 |
| » W: Moose Haas (9-2) L: Jim Gott (6-9) | Third | 3 out |
| Saturday, August 6 |
| » Lost to Brewers (60-46), 3-0 | County Stadium (1-4) | 60-47 | Lost 3 |
| » W: Chuck Porter (4-5) L: Doyle Alexander (0-6) | Fifth | 3 out |
| Sunday, August 7 |
| » Lost to Brewers (61-46), 9-6 | County Stadium (1-5) | 60-48 | Lost 4 |
| » W: Mike Caldwell (9-8) L: Luis Leal (10-10) S: Pete Ladd (11) | Fifth | 3 out |
| Monday, August 8 |
| » Lost to Yankees (60-47), 8-3 | Yankee Stadium (1-3) | 60-49 | Lost 5 |
| » W: Ron Guidry (13-7) L: Jim Clancy (12-7) | Fifth | 3½ out |
| » Lost to Yankees (61-47), 11-3 | Yankee Stadium (1-4) | 60-50 | Lost 6 |
| » W: Bob Shirley (4-6) L: Matt Williams (1-1) S: George Frazier (4) | Fifth | 3½ out |
| Tuesday, August 9 |
| » Defeated Yankees (61-48), 8-0 | Yankee Stadium (2-4) | 61-50 | |
| » W: Dave Stieb (12-10) L: Shane Rawley (10-10) | Fifth | 2½ out |
| Wednesday, August 10 |
| » Lost to Yankees (62-48), 8-3 | Yankee Stadium (2-5) | 61-51 | |
| » W: Dave Righetti (13-3) L: Jim Gott (6-10) | Fourth | 2½ out |
| Thursday, August 11 |
| » Lost to Brewers (64-48), 6-4 | Exhibition Stadium (33-24) | 61-52 | Lost 2 |
| » W: Chuck Porter (5-5) L: Doyle Alexander (0-7) S: Pete Ladd (13) | Fifth | 3½ out |
| Friday, August 12 |
| » Defeated Brewers (64-49), 5-4 | Exhibition Stadium (34-24) | 62-52 | |
| » W: Joey McLaughlin (5-2) L: Jim Slaton (9-5) | Fourth | 2½ out |
| Saturday, August 13 |
| » Defeated Brewers (64-50), 3-1 | Exhibition Stadium (35-24) | 63-52 | Won 2 |
| » W: Jim Clancy (13-7) L: Bob McClure (9-9) S: Dave Geisel (3) | Fifth | 2½ out |
| Sunday, August 14 |
| » Defeated Brewers (64-51), 4-3 | Exhibition Stadium (36-24) | 64-52 | Won 3 |
| » W: Dave Stieb (13-10) L: Pete Ladd (3-3) S: Joey McLaughlin (9) | Fifth | 1½ out |
| Monday, August 15 |
| » Defeated Indians (49-68), 3-2 | Cleveland Stadium (3-1) | 65-52 | Won 4 |
| » W: Randy Moffitt (6-0) L: Dan Spillner (1-8) | Fourth | 1½ out |
| Tuesday, August 16 |
| » Lost to Indians (50-68), 3-2 | Cleveland Stadium (3-2) | 65-53 | |
| » W: Jamie Easterly (2-1) L: Randy Moffitt (6-1) | Fourth | 2 out |
| » Defeated Indians (50-69), 9-6 | Cleveland Stadium (4-2) | 66-53 | |
| » W: Joey McLaughlin (6-2) L: Bud Anderson (0-4) | Fourth | 2 out |
| Wednesday, August 17 |
| » Defeated Indians (50-70), 6-5 | Cleveland Stadium (5-2) | 67-53 | Won 2 |
| » W: Joey McLaughlin (7-2) L: Rick Sutcliffe (13-9) S: Roy Lee Jackson (3) | Fourth | 1½ out |
| Friday, August 19 |
| » Defeated Red Sox (58-62), 8-7 | Fenway Park (2-1) | 68-53 | Won 3 |
| » W: Jim Acker (3-1) L: Mark Clear (3-5) S: Roy Lee Jackson (4) | Fourth | 1½ out |
| Saturday, August 20 |
| » Lost to Red Sox (59-62), 5-2 | Fenway Park (2-2) | 68-54 | |
| » W: Dennis Eckersley (7-9) L: Dave Stieb (13-11) S: Bob Stanley (23) | Fourth | 2½ out |
| Sunday, August 21 |
| » Defeated Red Sox (59-63), 7-3 | Fenway Park (3-2) | 69-54 | |
| » W: Jim Gott (7-10) L: Bruce Hurst (9-10) | Fourth | 1½ out |
| Monday, August 22 |
| » Lost to Red Sox (60-63), 4-2 | Fenway Park (3-3) | 69-55 | |
| » W: Bob Ojeda (6-6) L: Doyle Alexander (0-8) S: Bob Stanley (24) | Fourth | 2½ out |
| Tuesday, August 23 |
| » Defeated Orioles (69-52), 9-3 | Memorial Stadium (2-3) | 70-55 | |
| » W: Luis Leal (11-10) L: Mike Flanagan (7-3) | Fourth | 1½ out |
| Wednesday, August 24 |
| » Lost to Orioles (70-52), 7-4 | Memorial Stadium (2-4) | 70-56 | |
| » W: Tippy Martinez (7-3) L: Joey McLaughlin (7-3) | Fourth | 2½ out |
| Thursday, August 25 |
| » Lost to Orioles (71-52), 2-1 | Memorial Stadium (2-5) | 70-57 | Lost 2 |
| » W: Tippy Martinez (8-3) L: Roy Lee Jackson (8-2) | Fifth | 3½ out |
| Friday, August 26 |
| » Lost to Tigers (72-54), 4-3 | Tiger Stadium (2-2) | 70-58 | Lost 3 |
| » W: Aurelio Lopez (8-5) L: Jim Gott (7-11) | Fifth | 4 out |
| Saturday, August 27 |
| » Defeated Tigers (72-55), 7-4 | Tiger Stadium (3-2) | 71-58 | |
| » W: Doyle Alexander (1-8) L: Aurelio Lopez (8-6) S: Dave Geisel (4) | Fifth | 4 out |
| Sunday, August 28 |
| » Lost to Tigers (73-55), 4-2 | Tiger Stadium (3-3) | 71-59 | |
| » W: Jack Morris (17-8) L: Joey McLaughlin (7-4) | Fifth | 5 out |
| Monday, August 29 |
| » Defeated Red Sox (61-69), 5-1 | Exhibition Stadium (37-24) | 72-59 | |
| » W: Jim Clancy (14-7) L: John Tudor (10-9) | Fifth | 5½ out |
| » Lost to Red Sox (62-69), 8-7 | Exhibition Stadium (37-25) | 72-60 | |
| » W: Mark Clear (4-5) L: Randy Moffitt (6-2) S: Bob Stanley (26) | Fifth | 5½ out |
| Tuesday, August 30 |
| » Lost to Red Sox (63-69), 5-4 | Exhibition Stadium (37-26) | 72-61 | Lost 2 |
| » W: John Henry Johnson (3-2) L: Roy Lee Jackson (8-3) S: Mark Clear (4) | Fifth | 6½ out |
| Wednesday, August 31 |
| » Lost to Orioles (77-52), 10-2 | Exhibition Stadium (37-27) | 72-62 | Lost 3 |
| » W: Mike Boddicker (12-6) L: Jim Gott (7-12) | Fifth | 7½ out |
| Thursday, September 1 |
| » Defeated Orioles (77-53), 5-3 | Exhibition Stadium (38-27) | 73-62 | |
| » W: Doyle Alexander (2-8) L: Jim Palmer (3-4) | Fourth | 6½ out |
| Friday, September 2 |
| » Lost to Tigers (76-57), 9-8 | Exhibition Stadium (38-28) | 73-63 | |
| » W: Aurelio Lopez (9-7) L: Jim Gott (7-13) | Fifth | 7 out |
| » Defeated Tigers (76-58), 8-7 | Exhibition Stadium (39-28) | 74-63 | |
| » W: Jim Acker (4-1) L: Milt Wilcox (8-9) S: Dave Geisel (5) | Fifth | 7 out |
| » Major-league debuts: Tony Fernandez and Mitch Webster (Blue Jays) |
| Saturday, September 3 |
| » Lost to Tigers (77-58), 7-4 | Exhibition Stadium (39-29) | 74-64 | |
| » W: Dan Petry (15-8) L: Jim Clancy (14-8) S: John Martin (1) | Fifth | 8 out |
| Sunday, September 4 |
| » Defeated Tigers (77-59), 6-3 | Exhibition Stadium (40-29) | 75-64 | |
| » W: Dave Stieb (14-11) L: Aurelio Lopez (9-8) | Fifth | 8 out |
| Monday, September 5 |
| » Defeated Angels (63-74), 7-0 | Exhibition Stadium (41-29) | 76-64 | Won 2 |
| » W: Jim Gott (8-13) L: Geoff Zahn (8-11) | Fifth | 7 out |
| Tuesday, September 6 |
| » Defeated Angels (63-75), 6-4 | Exhibition Stadium (42-29) | 77-64 | Won 3 |
| » W: Doyle Alexander (3-8) L: John Curtis (1-2) S: Jim Acker (1) | Fifth | 7 out |
| Wednesday, September 7 |
| » Lost to Angels (64-75), 9-6 | Exhibition Stadium (42-30) | 77-65 | |
| » W: Luis Sanchez (9-7) L: Dave Geisel (0-2) | Fifth | 8 out |
| Friday, September 9 |
| » Lost to Athletics (67-76), 7-5 | Exhibition Stadium (42-31) | 77-66 | Lost 2 |
| » W: Steve McCatty (6-7) L: Jim Clancy (14-9) S: Keith Atherton (3) | Fourth | 8 out |
| Saturday, September 10 |
| » Defeated Athletics (67-77), 7-5 | Exhibition Stadium (43-31) | 78-66 | |
| » W: Dave Stieb (15-11) L: Tom Underwood (8-7) S: Randy Moffitt (10) | Fifth | 8½ out |
| Sunday, September 11 |
| » Defeated Athletics (67-78), 16-6 | Exhibition Stadium (44-31) | 79-66 | Won 2 |
| » W: Jim Gott (9-13) L: Chris Codiroli (12-11) | Fifth | 8½ out |
| Tuesday, September 13 |
| » Defeated Mariners (55-88), 6-4 | Kingdome (4-1) | 80-66 | Won 3 |
| » W: Luis Leal (12-10) L: Bob Stoddard (8-15) S: Roy Lee Jackson (5) | Fourth | 9 out |
| Wednesday, September 14 |
| » Defeated Mariners (55-89), 4-3 | Kingdome (5-1) | 81-66 | Won 4 |
| » W: Doyle Alexander (4-8) L: Roy Thomas (3-1) | Fourth | 9 out |
| Thursday, September 15 |
| » Lost to Twins (63-84), 6-2 | Hubert H. Humphrey Metrodome (2-2) | 81-67 | |
| » W: Ken Schrom (13-7) L: Dave Stieb (15-12) | Fourth | 9 out |
| Friday, September 16 |
| » Lost to Twins (64-84), 11-4 | Hubert H. Humphrey Metrodome (2-3) | 81-68 | Lost 2 |
| » W: Rick Lysander (5-12) L: Jim Gott (9-14) | Fourth | 10 out |
| Saturday, September 17 |
| » Defeated Twins (64-85), 13-3 | Hubert H. Humphrey Metrodome (3-3) | 82-68 | |
| » W: Luis Leal (13-10) L: Jay Pettibone (0-2) | Fourth | 10 out |
| Monday, September 19 |
| » Lost to Mariners (56-93), 9-6 | Exhibition Stadium (44-32) | 82-69 | |
| » W: Matt Young (11-14) L: Dave Geisel (0-3) S: Ed Vande Berg (5) | Fourth | 11½ out |
| Tuesday, September 20 |
| » Defeated Mariners (56-94), 7-3 | Exhibition Stadium (45-32) | 83-69 | |
| » W: Dave Stieb (16-12) L: Mike Moore (5-8) | Fourth | 10½ out |
| Wednesday, September 21 |
| » Defeated Mariners (56-95), 4-3 | Exhibition Stadium (46-32) | 84-69 | Won 2 |
| » W: Doyle Alexander (5-8) L: Bryan Clark (7-9) | Fourth | 11 out |
| Friday, September 23 |
| » Lost to Athletics (70-84), 2-0 | Oakland-Alameda County Stadium (1-3) | 84-70 | |
| » W: Tim Conroy (7-9) L: Luis Leal (13-11) | Fourth | 11½ out |
| Saturday, September 24 |
| » Lost to Athletics (71-84), 2-1 | Oakland-Alameda County Stadium (1-4) | 84-71 | Lost 2 |
| » W: Mike Warren (4-3) L: Jim Clancy (14-10) | Fourth | 11½ out |
| Sunday, September 25 |
| » Defeated Athletics (71-85), 8-6 | Oakland-Alameda County Stadium (2-4) | 85-71 | |