| Monday, March 15 |
| Former White Sox Eddie Mulligan dies in San Rafael, CA at the age of 88. |
| Friday, April 9 |
| » Major-league debuts: Jim Gott (Blue Jays) Kevin Bass and Doug Jones (Brewers) |
| Former White Sox Francisco Barrios dies in Hermosillo, Mexico at the age of 29. |
| Saturday, April 10 |
| » Major-league debuts: George Wright (Rangers) |
| Sunday, April 11 |
| » Defeated Yankees (0-1), 7-6 | Yankee Stadium (1-0) | 1-0 | |
| » W: Kevin Hickey (1-0) L: Rich Gossage (0-1) | First | -- |
| » Defeated Yankees (0-2), 2-0 | Yankee Stadium (2-0) | 2-0 | Won 2 |
| » W: Britt Burns (1-0) L: Tommy John (0-1) S: Salome Barojas (1) | First | -- |
| » Major-league debuts: Salome Barojas (White Sox) |
| Monday, April 12 |
| » Defeated Red Sox (2-2), 3-2 | Fenway Park (1-0) | 3-0 | Won 3 |
| » W: Richard Dotson (1-0) L: Mike Torrez (0-1) S: Salome Barojas (2) | First | -- |
| Wednesday, April 14 |
| » Defeated Red Sox (2-3), 5-4 | Fenway Park (2-0) | 4-0 | Won 4 |
| » W: Steve Trout (1-0) L: Bob Stanley (0-1) S: Salome Barojas (3) | First | -- |
| Thursday, April 15 |
| » Defeated Red Sox (2-4), 8-4 | Fenway Park (3-0) | 5-0 | Won 5 |
| » W: Dennis Lamp (1-0) L: Bob Ojeda (0-2) S: Jerry Koosman (1) | First | -- |
| Saturday, April 17 |
| » Defeated Orioles (2-5), 3-1 | Comiskey Park I (1-0) | 6-0 | Won 6 |
| » W: Britt Burns (2-0) L: Dennis Martinez (1-1) S: Salome Barojas (4) | First | -- |
| » Defeated Orioles (2-6), 10-6 | Comiskey Park I (2-0) | 7-0 | Won 7 |
| » W: La Marr Hoyt (1-0) L: Tippy Martinez (0-1) | First | -- |
| Sunday, April 18 |
| » Defeated Orioles (2-7), 6-4 | Comiskey Park I (3-0) | 8-0 | Won 8 |
| » W: La Marr Hoyt (2-0) L: Scott McGregor (0-2) S: Salome Barojas (5) | First | -- |
| Tuesday, April 20 |
| » Lost to Yankees (4-5), 11-2 | Comiskey Park I (3-1) | 8-1 | |
| » W: Mike Morgan (2-0) L: Steve Trout (1-1) | First | -- |
| Wednesday, April 21 |
| » Lost to Yankees (5-5), 1-0 | Comiskey Park I (3-2) | 8-2 | Lost 2 |
| » W: Ron Guidry (2-0) L: Richard Dotson (1-1) | First | -- |
| Friday, April 23 |
| » Defeated Orioles (2-10), 4-2 | Memorial Stadium (1-0) | 9-2 | |
| » W: La Marr Hoyt (3-0) L: Jim Palmer (0-1) S: Jerry Koosman (2) | First | -- |
| Saturday, April 24 |
| » Lost to Orioles (3-10), 7-4 | Memorial Stadium (1-1) | 9-3 | |
| » W: Sammy Stewart (2-1) L: Kevin Hickey (1-1) | First | -- |
| Sunday, April 25 |
| » Lost to Orioles (4-10), 2-1 | Memorial Stadium (1-2) | 9-4 | Lost 2 |
| » W: Dennis Martinez (2-2) L: Steve Trout (1-2) S: Tippy Martinez (1) | Second | 2½ out |
| Monday, April 26 |
| » Lost to Red Sox (10-6), 3-2 | Comiskey Park I (3-3) | 9-5 | Lost 3 |
| » W: Luis Aponte (2-0) L: Richard Dotson (1-2) | Second | 2½ out |
| » Lost to Red Sox (11-6), 5-0 | Comiskey Park I (3-4) | 9-6 | Lost 4 |
| » W: Chuck Rainey (1-0) L: Chico Escarrega (0-1) | Second | 2½ out |
| Tuesday, April 27 |
| » Defeated Brewers (8-7), 11-2 | County Stadium (1-0) | 10-6 | |
| » W: La Marr Hoyt (4-0) L: Randy Lerch (1-1) | Second | 2½ out |
| Wednesday, April 28 |
| » Lost to Brewers (9-7), 2-1 | County Stadium (1-1) | 10-7 | |
| » W: Rollie Fingers (2-2) L: Britt Burns (2-1) | Second | 2½ out |
| Thursday, April 29 |
| » Defeated Tigers (12-8), 3-2 | Comiskey Park I (4-4) | 11-7 | |
| » W: Dennis Lamp (2-0) L: Larry Pashnick (1-1) S: Salome Barojas (6) | Second | 2½ out |
| Friday, April 30 |
| » Lost to Tigers (13-8), 6-4 | Comiskey Park I (4-5) | 11-8 | |
| » W: Kevin Saucier (3-1) L: Jerry Koosman (0-1) S: Elias Sosa (3) | Second | 2½ out |
| Saturday, May 1 |
| » Lost to Tigers (14-8), 5-2 | Comiskey Park I (4-6) | 11-9 | Lost 2 |
| » W: Dan Petry (3-2) L: Richard Dotson (1-3) S: Dave Rozema (1) | Third | 3½ out |
| Sunday, May 2 |
| » Defeated Tigers (14-9), 10-3 | Comiskey Park I (5-6) | 12-9 | |
| » W: La Marr Hoyt (5-0) L: Jack Morris (4-2) | Second | 2½ out |
| Tuesday, May 4 |
| » Defeated Blue Jays (9-14), 4-3 | Comiskey Park I (6-6) | 13-9 | Won 2 |
| » W: Britt Burns (3-1) L: Dave Stieb (1-3) S: Salome Barojas (7) | Second | 2 out |
| Wednesday, May 5 |
| » Defeated Blue Jays (9-15), 4-1 | Comiskey Park I (7-6) | 14-9 | Won 3 |
| » W: Steve Trout (2-2) L: Luis Leal (2-2) S: Dennis Lamp (1) | Second | 1½ out |
| Friday, May 7 |
| » Defeated Tigers (16-10), 8-5 | Tiger Stadium (1-0) | 15-9 | Won 4 |
| » W: La Marr Hoyt (6-0) L: Jack Morris (4-3) S: Chico Escarrega (1) | First | -- |
| Saturday, May 8 |
| » Defeated Tigers (16-11), 7-4 | Tiger Stadium (2-0) | 16-9 | Won 5 |
| » W: Jerry Koosman (1-1) L: Elias Sosa (1-1) | First | -- |
| Sunday, May 9 |
| » Defeated Tigers (16-12), 4-3 | Tiger Stadium (3-0) | 17-9 | Won 6 |
| » W: Richard Dotson (2-3) L: Larry Pashnick (1-2) S: Salome Barojas (8) | First | -- |
| Monday, May 10 |
| » Defeated Blue Jays (12-16), 6-3 | Exhibition Stadium (1-0) | 18-9 | Won 7 |
| » W: Britt Burns (4-1) L: Joey McLaughlin (1-2) S: Kevin Hickey (1) | First | -- |
| Tuesday, May 11 |
| » Lost to Blue Jays (13-16), 9-4 | Exhibition Stadium (1-1) | 18-10 | |
| » W: Jim Clancy (3-2) L: Steve Trout (2-3) | First | -- |
| Wednesday, May 12 |
| » Defeated Blue Jays (13-17), 9-2 | Exhibition Stadium (2-1) | 19-10 | |
| » W: Dennis Lamp (3-0) L: Mark Bomback (1-5) | First | -- |
| Thursday, May 13 |
| » Defeated Brewers (16-14), 13-2 | Comiskey Park I (8-6) | 20-10 | Won 2 |
| » W: La Marr Hoyt (7-0) L: Mike Caldwell (2-3) | First | -- |
| Friday, May 14 |
| » Lost to Brewers (17-14), 2-1 | Comiskey Park I (8-7) | 20-11 | |
| » W: Jim Slaton (3-0) L: Richard Dotson (2-4) S: Rollie Fingers (7) | First | -- |
| Saturday, May 15 |
| » Lost to Brewers (18-14), 8-3 | Comiskey Park I (8-8) | 20-12 | Lost 2 |
| » W: Dwight Bernard (2-0) L: Britt Burns (4-2) S: Rollie Fingers (8) | Second | 2 out |
| Sunday, May 16 |
| » Defeated Brewers (18-15), 6-1 | Comiskey Park I (9-8) | 21-12 | |
| » W: Steve Trout (3-3) L: Randy Lerch (3-3) S: Salome Barojas (9) | Second | 2 out |
| Monday, May 17 |
| » Defeated Rangers (10-21), 8-6 | Comiskey Park I (10-8) | 22-12 | Won 2 |
| » W: Dennis Lamp (4-0) L: Rick Honeycutt (0-4) S: Salome Barojas (10) | Second | 1½ out |
| Former White Sox Dixie Walker dies in Birmingham, AL at the age of 72. |
| Tuesday, May 18 |
| » Defeated Rangers (10-22), 10-2 | Comiskey Park I (11-8) | 23-12 | Won 3 |
| » W: La Marr Hoyt (8-0) L: Doc Medich (2-4) | Second | 1½ out |
| Wednesday, May 19 |
| » Defeated Rangers (10-23), 6-5 | Comiskey Park I (12-8) | 24-12 | Won 4 |
| » W: Salome Barojas (1-0) L: Danny Darwin (4-2) | Second | 1½ out |
| Friday, May 21 |
| » Defeated Indians (15-22), 3-2 | Comiskey Park I (13-8) | 25-12 | Won 5 |
| » W: Britt Burns (5-2) L: Dan Spillner (1-4) | First | -- |
| Saturday, May 22 |
| » Defeated Indians (15-23), 7-3 | Comiskey Park I (14-8) | 26-12 | Won 6 |
| » W: Steve Trout (4-3) L: John Denny (2-5) S: Jerry Koosman (3) | First | -- |
| Sunday, May 23 |
| » Lost to Indians (16-23), 6-4 | Comiskey Park I (14-9) | 26-13 | |
| » W: Dan Spillner (2-4) L: Jerry Koosman (1-2) | First | -- |
| Monday, May 24 |
| » Defeated Royals (22-18), 3-1 | Comiskey Park I (15-9) | 27-13 | |
| » W: La Marr Hoyt (9-0) L: Paul Splittorff (2-4) | First | -- |
| Tuesday, May 25 |
| » Lost to Royals (23-18), 7-4 | Comiskey Park I (15-10) | 27-14 | |
| » W: Keith Creel (1-0) L: Richard Dotson (2-5) S: Dan Quisenberry (12) | Second | 1½ out |
| » Major-league debuts: Keith Creel (Royals) |
| Wednesday, May 26 |
| » Defeated Royals (23-19), 7-5 | Comiskey Park I (16-10) | 28-14 | |
| » W: Britt Burns (6-2) L: Larry Gura (4-2) S: Salome Barojas (11) | First | -- |
| Friday, May 28 |
| » Lost to Indians (20-23), 5-2 | Cleveland Stadium (0-1) | 28-15 | |
| » W: John Denny (3-5) L: Steve Trout (4-4) | Second | 1½ out |
| Saturday, May 29 |
| » Lost to Indians (21-23), 5-2 | Cleveland Stadium (0-2) | 28-16 | Lost 2 |
| » W: Rick Sutcliffe (3-1) L: La Marr Hoyt (9-1) S: Dan Spillner (4) | Second | 1½ out |
| Sunday, May 30 |
| » Lost to Indians (22-23), 4-2 | Cleveland Stadium (0-3) | 28-17 | Lost 3 |
| » W: Len Barker (6-2) L: Dennis Lamp (4-1) | Second | 1½ out |
| Monday, May 31 |
| » Lost to Royals (25-21), 11-4 | Royals Stadium (0-1) | 28-18 | Lost 4 |
| » W: Larry Gura (5-2) L: Britt Burns (6-3) | Second | 1½ out |
| Tuesday, June 1 |
| » Lost to Royals (26-21), 4-3 | Royals Stadium (0-2) | 28-19 | Lost 5 |
| » W: Vida Blue (3-3) L: Richard Dotson (2-6) S: Dan Quisenberry (13) | Second | 1½ out |
| Wednesday, June 2 |
| » Lost to Royals (27-21), 7-6 | Royals Stadium (0-3) | 28-20 | Lost 6 |
| » W: Mike Armstrong (2-0) L: Salome Barojas (1-1) | Second | 1½ out |
| Friday, June 4 |
| » Lost to Rangers (16-29), 4-3 | Arlington Stadium (0-1) | 28-21 | Lost 7 |
| » W: Charlie Hough (5-3) L: La Marr Hoyt (9-2) S: Paul Mirabella (2) | Second | 1½ out |
| Saturday, June 5 |
| » Defeated Rangers (16-30), 2-1 | Arlington Stadium (1-1) | 29-21 | |
| » W: Britt Burns (7-3) L: Rick Honeycutt (0-7) S: Salome Barojas (12) | Second | 1½ out |
| Sunday, June 6 |
| » Lost to Rangers (17-30), 5-4 | Arlington Stadium (1-2) | 29-22 | |
| » W: Dave Schmidt (1-1) L: Jerry Koosman (1-3) | Third | ½ out |
| Monday, June 7 |
| » Defeated Athletics (25-31), 6-5 | Comiskey Park I (17-10) | 30-22 | |
| » W: Kevin Hickey (2-1) L: Dave Beard (4-3) | Second | ½ out |
| Tuesday, June 8 |
| » Defeated Athletics (25-32), 5-4 | Comiskey Park I (18-10) | 31-22 | Won 2 |
| » W: Salome Barojas (2-1) L: Bo McLaughlin (0-4) | Second | ½ out |
| Former White Sox Irv Jeffries dies in Louisville, KY at the age of 77. |
| Wednesday, June 9 |
| » Lost to Athletics (26-32), 5-4 | Comiskey Park I (18-11) | 31-23 | |
| » W: Matt Keough (5-7) L: La Marr Hoyt (9-3) | Second | 1½ out |
| Thursday, June 10 |
| » Defeated Angels (32-25), 7-6 | Comiskey Park I (19-11) | 32-23 | |
| » W: Salome Barojas (3-1) L: Dave Goltz (0-2) | Second | ½ out |
| Friday, June 11 |
| » Lost to Angels (33-25), 6-5 | Comiskey Park I (19-12) | 32-24 | |
| » W: Bruce Kison (5-2) L: Richard Dotson (2-7) S: Doug Corbett (7) | Second | 1½ out |
| Saturday, June 12 |
| » Lost to Angels (34-25), 3-0 | Comiskey Park I (19-13) | 32-25 | Lost 2 |
| » W: Ken Forsch (5-6) L: Steve Trout (4-5) | Third | 1½ out |
| Sunday, June 13 |
| » Lost to Angels (35-25), 7-4 | Comiskey Park I (19-14) | 32-26 | Lost 3 |
| » W: Geoff Zahn (7-2) L: Dennis Lamp (4-2) | Third | 2 out |
| Tuesday, June 15 |
| » Defeated Athletics (29-34), 7-0 | Oakland-Alameda County Stadium (1-0) | 33-26 | |
| » W: La Marr Hoyt (10-3) L: Brian Kingman (0-2) | Third | 2 out |
| Wednesday, June 16 |
| » Defeated Athletics (29-35), 7-6 | Oakland-Alameda County Stadium (2-0) | 34-26 | Won 2 |
| » W: Salome Barojas (4-1) L: Dave Beard (4-4) | Third | 1 out |
| Thursday, June 17 |
| » Defeated Athletics (29-36), 11-7 | Oakland-Alameda County Stadium (3-0) | 35-26 | Won 3 |
| » W: Steve Trout (5-5) L: Mike Norris (3-6) S: Kevin Hickey (2) | Third | 1 out |
| Friday, June 18 |
| » Lost to Angels (38-26), 7-2 | Anaheim Stadium (0-1) | 35-27 | |
| » W: Angel Moreno (3-6) L: Dennis Lamp (4-3) | Third | 2 out |
| Saturday, June 19 |
| » Defeated Angels (38-27), 7-6 | Anaheim Stadium (1-1) | 36-27 | |
| » W: Richard Dotson (3-7) L: Geoff Zahn (7-3) S: Kevin Hickey (3) | Third | 1 out |
| Sunday, June 20 |
| » Lost to Angels (39-27), 3-1 | Anaheim Stadium (1-2) | 36-28 | |
| » W: Mike Witt (4-1) L: La Marr Hoyt (10-4) | Third | 2 out |
| Monday, June 21 |
| » Defeated Twins (16-53), 5-4 | Comiskey Park I (20-14) | 37-28 | |
| » W: Salome Barojas (5-1) L: Terry Felton (0-6) | Third | 2 out |
| Future White Sox Arnie Munoz is born in Mao, D.R. |
| Tuesday, June 22 |
| » Defeated Twins (16-54), 6-5 | Comiskey Park I (21-14) | 38-28 | Won 2 |
| » W: Eddie Solomon (3-6) L: Terry Felton (0-7) | Third | 1 out |
| Wednesday, June 23 |
| » Lost to Twins (17-54), 6-3 | Comiskey Park I (21-15) | 38-29 | |
| » W: Paul Boris (1-1) L: Salome Barojas (5-2) S: Ron Davis (5) | Third | 2 out |
| Friday, June 25 |
| » Lost to Mariners (37-35), 1-0 | Kingdome (0-1) | 38-30 | Lost 2 |
| » W: Jim Beattie (5-4) L: La Marr Hoyt (10-5) S: Bill Caudill (12) | Third | 2½ out |
| Saturday, June 26 |
| » Defeated Mariners (37-36), 13-3 | Kingdome (1-1) | 39-30 | |
| » W: Britt Burns (8-3) L: Gaylord Perry (5-7) | Third | 2½ out |
| Sunday, June 27 |
| » Lost to Mariners (38-36), 6-5 | Kingdome (1-2) | 39-31 | |
| » W: Gene Nelson (6-8) L: Steve Trout (5-6) S: Bill Caudill (13) | Third | 3½ out |
| Monday, June 28 |
| » Defeated Twins (18-56), 8-7 | Hubert H. Humphrey Metrodome (1-0) | 40-31 | |
| » W: Dennis Lamp (5-3) L: Albert Williams (2-6) S: Salome Barojas (13) | Second | 3 out |
| Tuesday, June 29 |
| » Lost to Twins (19-56), 12-5 | Hubert H. Humphrey Metrodome (1-1) | 40-32 | |
| » W: Frank Viola (2-0) L: Richard Dotson (3-8) S: Terry Felton (2) | Third | 4 out |
| Wednesday, June 30 |
| » Lost to Twins (20-56), 4-3 | Hubert H. Humphrey Metrodome (1-2) | 40-33 | Lost 2 |
| » W: Bobby Castillo (3-5) L: La Marr Hoyt (10-6) S: Ron Davis (6) | Third | 4 out |
| Thursday, July 1 |
| » Lost to Twins (21-56), 9-2 | Hubert H. Humphrey Metrodome (1-3) | 40-34 | Lost 3 |
| » W: Pete Redfern (4-8) L: Britt Burns (8-4) | Third | 4 out |
| Former White Sox Ray Scarborough dies in Mount Olive, NC at the age of 65. |
| Saturday, July 3 |
| » Defeated Mariners (41-37), 7-6 | Comiskey Park I (22-15) | 41-34 | |
| » W: Jerry Koosman (2-3) L: Mike Stanton (1-2) | Third | 2½ out |
| Former White Sox Spence Harris dies in Minneapolis, MN at the age of 82. |
| Sunday, July 4 |
| » Lost to Mariners (42-37), 3-1 | Comiskey Park I (22-16) | 41-35 | |
| » W: Floyd Bannister (8-4) L: Richard Dotson (3-9) S: Bill Caudill (15) | Third | 3 out |
| Monday, July 5 |
| » Lost to Brewers (45-33), 10-4 | Comiskey Park I (22-17) | 41-36 | Lost 2 |
| » W: Jim Slaton (6-1) L: La Marr Hoyt (10-7) | Fourth | 3½ out |
| Wednesday, July 7 |
| » Defeated Tigers (40-37), 7-0 | Comiskey Park I (23-17) | 42-36 | |
| » W: Dennis Lamp (6-3) L: Jerry Ujdur (1-5) | Third | 4 out |
| Thursday, July 8 |
| » Defeated Tigers (40-38), 3-2 | Comiskey Park I (24-17) | 43-36 | Won 2 |
| » W: La Marr Hoyt (11-7) L: Dan Petry (8-6) | Third | 3 out |
| Friday, July 9 |
| » Lost to Blue Jays (37-45), 7-6 | Exhibition Stadium (2-2) | 43-37 | |
| » W: Dale Murray (6-3) L: Richard Dotson (3-10) S: Joey McLaughlin (5) | Third | 3 out |
| Saturday, July 10 |
| » Defeated Blue Jays (37-46), 6-5 | Exhibition Stadium (3-2) | 44-37 | |
| » W: Chico Escarrega (1-1) L: Jim Gott (1-5) S: Kevin Hickey (4) | Third | 2 out |
| Sunday, July 11 |
| » Defeated Blue Jays (37-47), 16-7 | Exhibition Stadium (4-2) | 45-37 | Won 2 |
| » W: Britt Burns (9-4) L: Jim Clancy (7-7) | Third | 2 out |
| Thursday, July 15 |
| » Lost to Brewers (49-35), 8-4 | County Stadium (1-2) | 45-38 | |
| » W: Jim Slaton (7-1) L: Dennis Lamp (6-4) | Third | 3½ out |
| » Lost to Brewers (50-35), 5-4 | County Stadium (1-3) | 45-39 | Lost 2 |
| » W: Mike Caldwell (7-8) L: La Marr Hoyt (11-8) S: Rollie Fingers (19) | Third | 3½ out |
| Friday, July 16 |
| » Lost to Brewers (51-35), 5-3 | County Stadium (1-4) | 45-40 | Lost 3 |
| » W: Moose Haas (6-5) L: Jerry Koosman (2-4) S: Rollie Fingers (20) | Third | 4½ out |
| Saturday, July 17 |
| » Lost to Brewers (52-35), 5-2 | County Stadium (1-5) | 45-41 | Lost 4 |
| » W: Pete Ladd (1-0) L: Salome Barojas (5-3) S: Rollie Fingers (21) | Third | 4½ out |
| Sunday, July 18 |
| » Lost to Brewers (53-35), 9-3 | County Stadium (1-6) | 45-42 | Lost 5 |
| » W: Randy Lerch (7-5) L: Rich Barnes (0-1) S: Dwight Bernard (4) | Third | 4½ out |
| Monday, July 19 |
| » Defeated Tigers (45-43), 6-0 | Tiger Stadium (4-0) | 46-42 | |
| » W: Dennis Lamp (7-4) L: Milt Wilcox (6-6) | Third | 4½ out |
| Tuesday, July 20 |
| » Lost to Tigers (46-43), 1-0 | Tiger Stadium (4-1) | 46-43 | |
| » W: Dan Petry (10-6) L: La Marr Hoyt (11-9) | Third | 5½ out |
| Wednesday, July 21 |
| » Defeated Tigers (46-44), 9-3 | Tiger Stadium (5-1) | 47-43 | |
| » W: Salome Barojas (6-3) L: Dave Tobik (2-5) | Third | 4½ out |
| Thursday, July 22 |
| » Defeated Blue Jays (43-49), 3-2 | Comiskey Park I (25-17) | 48-43 | Won 2 |
| » W: Britt Burns (10-4) L: Joey McLaughlin (8-4) | Third | 4 out |
| Friday, July 23 |
| » Lost to Blue Jays (44-49), 7-1 | Comiskey Park I (25-18) | 48-44 | |
| » W: Luis Leal (7-7) L: Rich Barnes (0-2) S: Roy Lee Jackson (5) | Third | 4 out |
| Saturday, July 24 |
| » Lost to Blue Jays (45-49), 8-1 | Comiskey Park I (25-19) | 48-45 | Lost 2 |
| » W: Dave Stieb (10-10) L: Dennis Lamp (7-5) S: Dale Murray (1) | Fourth | 4 out |
| Sunday, July 25 |
| » Defeated Blue Jays (45-50), 5-3 | Comiskey Park I (26-19) | 49-45 | |
| » W: La Marr Hoyt (12-9) L: Jim Clancy (8-9) | Third | 4 out |
| Monday, July 26 |
| » Lost to Orioles (52-41), 6-2 | Memorial Stadium (1-3) | 49-46 | |
| » W: Mike Flanagan (7-8) L: Jerry Koosman (2-5) S: Tim Stoddard (10) | Third | 4 out |
| Tuesday, July 27 |
| » Lost to Orioles (53-41), 5-3 | Memorial Stadium (1-4) | 49-47 | Lost 2 |
| » W: Tippy Martinez (5-4) L: Kevin Hickey (2-2) | Fourth | 5 out |
| Wednesday, July 28 |
| » Lost to Orioles (54-41), 2-1 | Memorial Stadium (1-5) | 49-48 | Lost 3 |
| » W: Scott McGregor (12-7) L: Richard Dotson (3-11) S: Tippy Martinez (11) | Fourth | 6 out |
| Thursday, July 29 |
| » Lost to Red Sox (58-41), 7-3 | Comiskey Park I (26-20) | 49-49 | Lost 4 |
| » W: Chuck Rainey (6-3) L: Dennis Lamp (7-6) S: Mark Clear (12) | Fourth | 7 out |
| Friday, July 30 |
| » Defeated Red Sox (58-42), 9-6 | Comiskey Park I (27-20) | 50-49 | |
| » W: La Marr Hoyt (13-9) L: Mike Torrez (7-6) S: Salome Barojas (14) | Fourth | 7 out |
| Saturday, July 31 |
| » Defeated Red Sox (58-43), 7-5 | Comiskey Park I (28-20) | 51-49 | Won 2 |
| » W: Britt Burns (11-4) L: Dennis Eckersley (11-9) S: Salome Barojas (15) | Fourth | 6 out |
| Sunday, August 1 |
| » Defeated Red Sox (58-44), 4-2 | Comiskey Park I (29-20) | 52-49 | Won 3 |
| » W: Jerry Koosman (3-5) L: Bruce Hurst (3-5) S: Dennis Lamp (2) | Third | 6 out |
| Tuesday, August 3 |
| » Defeated Yankees (50-49), 1-0 | Yankee Stadium (3-0) | 53-49 | Won 4 |
| » W: Steve Trout (6-6) L: Shane Rawley (6-6) S: Dennis Lamp (3) | Third | 5 out |
| » Defeated Yankees (50-50), 14-2 | Yankee Stadium (4-0) | 54-49 | Won 5 |
| » W: Richard Dotson (4-11) L: Roger Erickson (8-8) S: Rich Barnes (1) | Third | 5 out |
| Wednesday, August 4 |
| » Lost to Yankees (51-50), 6-2 | Yankee Stadium (4-1) | 54-50 | |
| » W: Ron Guidry (11-4) L: La Marr Hoyt (13-10) S: Rich Gossage (20) | Third | 4½ out |
| » Defeated Yankees (51-51), 7-0 | Yankee Stadium (5-1) | 55-50 | |
| » W: Britt Burns (12-4) L: Tommy John (6-9) | Third | 4½ out |
| Friday, August 6 |
| » Defeated Red Sox (60-47), 6-3 | Fenway Park (4-0) | 56-50 | Won 2 |
| » W: Jerry Koosman (4-5) L: Bruce Hurst (3-6) S: Dennis Lamp (4) | Third | 4½ out |
| Saturday, August 7 |
| » Defeated Red Sox (60-48), 7-3 | Fenway Park (5-0) | 57-50 | Won 3 |
| » W: Richard Dotson (5-11) L: John Tudor (7-9) S: Kevin Hickey (5) | Third | 4 out |
| Sunday, August 8 |
| » Lost to Red Sox (61-48), 12-6 | Fenway Park (5-1) | 57-51 | |
| » W: Tom Burgmeier (5-0) L: Steve Trout (6-7) | Third | 5 out |
| Monday, August 9 |
| » Defeated Orioles (59-50), 9-5 | Comiskey Park I (30-20) | 58-51 | |
| » W: Kevin Hickey (3-2) L: Tippy Martinez (6-6) | Third | 4½ out |
| Tuesday, August 10 |
| » Defeated Orioles (59-51), 9-4 | Comiskey Park I (31-20) | 59-51 | Won 2 |
| » W: Britt Burns (13-4) L: Scott McGregor (12-10) | Second | 3½ out |
| Wednesday, August 11 |
| » Defeated Orioles (59-52), 4-1 | Comiskey Park I (32-20) | 60-51 | Won 3 |
| » W: Richard Dotson (6-11) L: Dennis Martinez (11-10) S: Dennis Lamp (5) | Second | 3½ out |
| Thursday, August 12 |
| » Defeated Yankees (55-56), 2-1 | Comiskey Park I (33-20) | 61-51 | Won 4 |
| » W: Jerry Koosman (5-5) L: Mike Morgan (6-7) | Third | 3½ out |
| Friday, August 13 |
| » Lost to Yankees (56-56), 4-3 | Comiskey Park I (33-21) | 61-52 | |
| » W: Tommy John (8-9) L: Steve Trout (6-8) S: Rich Gossage (23) | Third | 4½ out |
| Saturday, August 14 |
| » Defeated Yankees (56-57), 6-0 | Comiskey Park I (34-21) | 62-52 | |
| » W: La Marr Hoyt (14-10) L: Shane Rawley (6-8) | Third | 3½ out |
| Sunday, August 15 |
| » Defeated Yankees (56-58), 6-4 | Comiskey Park I (35-21) | 63-52 | Won 2 |
| » W: Dennis Lamp (8-6) L: Rich Gossage (4-5) | Third | 3 out |
| Monday, August 16 |
| » Defeated Rangers (46-69), 6-1 | Arlington Stadium (2-2) | 64-52 | Won 3 |
| » W: Richard Dotson (7-11) L: Rick Honeycutt (5-14) | Third | 2½ out |
| Tuesday, August 17 |
| » Lost to Rangers (47-69), 4-3 | Arlington Stadium (2-3) | 64-53 | |
| » W: Danny Darwin (9-6) L: Dennis Lamp (8-7) | Third | 3½ out |
| Wednesday, August 18 |
| » Lost to Rangers (48-69), 11-1 | Arlington Stadium (2-4) | 64-54 | Lost 2 |
| » W: Frank Tanana (6-13) L: Steve Trout (6-9) | Third | 3½ out |
| Thursday, August 19 |
| » Lost to Royals (68-52), 3-0 | Royals Stadium (0-4) | 64-55 | Lost 3 |
| » W: Larry Gura (15-8) L: La Marr Hoyt (14-11) S: Dan Quisenberry (27) | Third | 4½ out |
| Friday, August 20 |
| » Lost to Royals (69-52), 13-5 | Royals Stadium (0-5) | 64-56 | Lost 4 |
| » W: Dennis Leonard (7-3) L: Chico Escarrega (1-2) S: Mike Armstrong (5) | Second | 4½ out |
| Saturday, August 21 |
| » Lost to Royals (70-52), 4-3 | Royals Stadium (0-6) | 64-57 | Lost 5 |
| » W: Dan Quisenberry (7-5) L: Salome Barojas (6-4) | Second | 5½ out |
| Sunday, August 22 |
| » Defeated Royals (70-53), 12-3 | Royals Stadium (1-6) | 65-57 | |
| » W: Jerry Koosman (6-5) L: Paul Splittorff (8-7) | Third | 5½ out |
| Monday, August 23 |
| » Lost to Indians (60-60), 5-4 | Cleveland Stadium (0-4) | 65-58 | |
| » W: Dan Spillner (10-7) L: Chico Escarrega (1-3) | Third | 6½ out |
| Tuesday, August 24 |
| » Lost to Indians (61-60), 14-7 | Cleveland Stadium (0-5) | 65-59 | Lost 2 |
| » W: Rick Waits (2-12) L: La Marr Hoyt (14-12) S: Tom Brennan (1) | Third | 6½ out |
| Wednesday, August 25 |
| » Defeated Indians (61-61), 5-1 | Cleveland Stadium (1-5) | 66-59 | |
| » W: Richard Dotson (8-11) L: Len Barker (12-9) S: Sparky Lyle (3) | Third | 6 out |
| Friday, August 27 |
| » Lost to Royals (74-54), 7-1 | Comiskey Park I (35-22) | 66-60 | |
| » W: Paul Splittorff (9-7) L: Jerry Koosman (6-6) | Second | 7 out |
| Saturday, August 28 |
| » Lost to Royals (75-54), 10-1 | Comiskey Park I (35-23) | 66-61 | Lost 2 |
| » W: Vida Blue (10-9) L: Britt Burns (13-5) | Third | 8 out |
| Sunday, August 29 |
| » Lost to Royals (76-54), 7-4 | Comiskey Park I (35-24) | 66-62 | Lost 3 |
| » W: Larry Gura (17-8) L: La Marr Hoyt (14-13) S: Dan Quisenberry (31) | Third | 9 out |
| Monday, August 30 |
| » Defeated Indians (61-65), 4-1 | Comiskey Park I (36-24) | 67-62 | |
| » W: Richard Dotson (9-11) L: Rick Waits (2-13) S: Jim Kern (3) | Third | 9 out |
| Tuesday, August 31 |
| » Defeated Indians (61-66), 14-6 | Comiskey Park I (37-24) | 68-62 | Won 2 |
| » W: Kevin Hickey (4-2) L: Len Barker (12-10) | Third | 8 out |
| Wednesday, September 1 |
| » Defeated Indians (61-67), 6-0 | Comiskey Park I (38-24) | 69-62 | Won 3 |
| » W: Jerry Koosman (7-6) L: Lary Sorensen (10-11) | Third | 7 out |
| Thursday, September 2 |
| » Defeated Rangers (52-80), 6-5 | Comiskey Park I (39-24) | 70-62 | Won 4 |
| » W: Jim Kern (4-5) L: Steve Comer (1-5) | Third | 6½ out |
| » Major-league debuts: Ron Kittle (White Sox) |
| Friday, September 3 |
| » Defeated Rangers (52-81), 7-5 | Comiskey Park I (40-24) | 71-62 | Won 5 |
| » W: Warren Brusstar (3-3) L: Dave Schmidt (4-6) S: Jim Kern (4) | Third | 6½ out |
| » Major-league debuts: Pete O'Brien (Rangers) |
| Saturday, September 4 |
| » Defeated Rangers (52-82), 4-0 | Comiskey Park I (41-24) | 72-62 | Won 6 |
| » W: Richard Dotson (10-11) L: Frank Tanana (6-16) | Third | 5½ out |
| Sunday, September 5 |
| » Lost to Rangers (53-82), 10-7 | Comiskey Park I (41-25) | 72-63 | |
| » W: Jon Matlack (6-6) L: Salome Barojas (6-5) S: Dave Schmidt (6) | Third | 5½ out |
| Monday, September 6 |
| » Lost to Angels (77-60), 8-6 | Anaheim Stadium (1-3) | 72-64 | Lost 2 |
| » W: Steve Renko (11-6) L: Jim Kern (4-6) | Third | 5½ out |
| Tuesday, September 7 |
| » Defeated Angels (77-61), 7-4 | Anaheim Stadium (2-3) | 73-64 | |
| » W: La Marr Hoyt (15-13) L: Tommy John (11-11) S: Salome Barojas (16) | Third | 4½ out |
| Former White Sox Ken Boyer dies in St.Louis, MO at the age of 52. |
| Wednesday, September 8 |
| » Defeated Angels (77-62), 5-3 | Anaheim Stadium (3-3) | 74-64 | Won 2 |
| » W: Richard Dotson (11-11) L: John Curtis (8-7) S: Salome Barojas (17) | Third | 4½ out |
| Friday, September 10 |
| » Defeated Athletics (59-82), 9-3 | Oakland-Alameda County Stadium (4-0) | 75-64 | Won 3 |
| » W: Dennis Lamp (9-7) L: Mike Norris (7-10) | Third | 3½ out |
| Saturday, September 11 |
| » Defeated Athletics (59-83), 2-0 | Oakland-Alameda County Stadium (5-0) | 76-64 | Won 4 |
| » W: Jerry Koosman (8-6) L: Chris Codiroli (0-1) S: Salome Barojas (18) | Third | 3½ out |
| Sunday, September 12 |
| » Lost to Athletics (60-83), 4-2 | Oakland-Alameda County Stadium (5-1) | 76-65 | |
| » W: Rick Langford (11-15) L: La Marr Hoyt (15-14) S: Bob Owchinko (3) | Third | 4½ out |
| Monday, September 13 |
| » Lost to Angels (81-62), 6-4 | Comiskey Park I (41-26) | 76-66 | Lost 2 |
| » W: Luis Sanchez (6-2) L: Kevin Hickey (4-3) | Third | 5½ out |
| » Major-league debuts: Gary Pettis (Angels) |
| Tuesday, September 14 |
| » Lost to Angels (82-62), 7-0 | Comiskey Park I (41-27) | 76-67 | Lost 3 |
| » W: Bruce Kison (8-5) L: Dennis Lamp (9-8) | Third | 6½ out |
| Wednesday, September 15 |
| » Defeated Angels (82-63), 8-3 | Comiskey Park I (42-27) | 77-67 | |
| » W: Jerry Koosman (9-6) L: Geoff Zahn (16-8) | Third | 6½ out |
| Thursday, September 16 |
| » Defeated Athletics (60-86), 6-3 | Comiskey Park I (43-27) | 78-67 | Won 2 |
| » W: La Marr Hoyt (16-14) L: Steve Baker (0-1) S: Kevin Hickey (6) | Third | 5½ out |
| Friday, September 17 |
| » Major-league debuts: Stefan Wever (Yankees) |
| Saturday, September 18 |
| » Lost to Athletics (61-86), 2-1 | Comiskey Park I (43-28) | 78-68 | |
| » W: Chris Codiroli (1-1) L: Richard Dotson (11-12) S: Tom Underwood (6) | Third | 5½ out |
| » Lost to Athletics (62-86), 5-4 | Comiskey Park I (43-29) | 78-69 | Lost 2 |
| » W: Dave Beard (9-8) L: Salome Barojas (6-6) | Third | 5½ out |
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