| Wednesday, January 6 |
| Former Twin Wally Post dies in St.Henry, OH at the age of 53. |
| Wednesday, February 24 |
| Future Twin J.D. Durbin is born in Portland, OR. |
| Tuesday, April 6 |
| » Lost to Mariners (1-0), 11-7 | Hubert H. Humphrey Metrodome (0-1) | 0-1 | |
| » W: Floyd Bannister (1-0) L: Pete Redfern (0-1) S: Mike Stanton (1) | Third | 1 out |
| » Major-league debuts: Jim Eisenreich (Twins) |
| Wednesday, April 7 |
| » Defeated Mariners (1-1), 7-5 | Hubert H. Humphrey Metrodome (1-1) | 1-1 | |
| » W: Roger Erickson (1-0) L: Jim Beattie (0-1) S: Doug Corbett (1) | Second | 1 out |
| » Major-league debuts: Edwin Nunez and Ed Vande Berg (Mariners) |
| Thursday, April 8 |
| » Defeated Mariners (1-2), 4-1 | Hubert H. Humphrey Metrodome (2-1) | 2-1 | Won 2 |
| » W: Brad Havens (1-0) L: Gene Nelson (0-1) S: Doug Corbett (2) | First | -- |
| Friday, April 9 |
| » Defeated Angels (2-2), 2-1 | Hubert H. Humphrey Metrodome (3-1) | 3-1 | Won 3 |
| » W: Albert Williams (1-0) L: Angel Moreno (0-1) | First | -- |
| Saturday, April 10 |
| » Lost to Angels (3-2), 8-1 | Hubert H. Humphrey Metrodome (3-2) | 3-2 | |
| » W: Steve Renko (1-0) L: Darrell Jackson (0-1) | Third | 2 out |
| Sunday, April 11 |
| » Defeated Angels (3-3), 3-1 | Hubert H. Humphrey Metrodome (4-2) | 4-2 | |
| » W: Pete Redfern (1-1) L: Ken Forsch (0-1) | Second | 2 out |
| Tuesday, April 13 |
| » Lost to Athletics (4-3), 8-3 | Hubert H. Humphrey Metrodome (4-3) | 4-3 | |
| » W: Matt Keough (1-0) L: Roger Erickson (1-1) S: Tom Underwood (1) | Third | 2 out |
| Wednesday, April 14 |
| » Lost to Athletics (5-3), 7-5 | Hubert H. Humphrey Metrodome (4-4) | 4-4 | Lost 2 |
| » W: Jeff Jones (2-1) L: Fernando Arroyo (0-1) | Fourth | 2 out |
| Thursday, April 15 |
| » Defeated Athletics (5-4), 11-5 | Hubert H. Humphrey Metrodome (5-4) | 5-4 | |
| » W: Albert Williams (2-0) L: Rick Langford (1-1) S: Ron Davis (1) | Fourth | 2 out |
| Friday, April 16 |
| » Lost to Angels (7-3), 4-2 | Anaheim Stadium (0-1) | 5-5 | |
| » W: Don Aase (1-1) L: Doug Corbett (0-1) | Fifth | 2½ out |
| Saturday, April 17 |
| » Lost to Angels (8-3), 6-2 | Anaheim Stadium (0-2) | 5-6 | Lost 2 |
| » W: Ken Forsch (1-1) L: Terry Felton (0-1) | Sixth | 4 out |
| Sunday, April 18 |
| » Lost to Angels (9-3), 5-2 | Anaheim Stadium (0-3) | 5-7 | Lost 3 |
| » W: Geoff Zahn (2-0) L: Roger Erickson (1-2) | Sixth | 5 out |
| Monday, April 19 |
| » Defeated Athletics (6-7), 5-2 | Oakland-Alameda County Stadium (1-0) | 6-7 | |
| » W: Ron Davis (1-0) L: Rick Langford (1-2) | Fifth | 4½ out |
| Tuesday, April 20 |
| » Lost to Athletics (7-7), 4-3 | Oakland-Alameda County Stadium (1-1) | 6-8 | |
| » W: Dave Beard (1-0) L: Bobby Castillo (0-1) | Sixth | 4½ out |
| Wednesday, April 21 |
| » Lost to Athletics (8-7), 5-2 | Oakland-Alameda County Stadium (1-2) | 6-9 | Lost 2 |
| » W: Tom Underwood (1-1) L: Darrell Jackson (0-2) | Sixth | 4½ out |
| Thursday, April 22 |
| » Lost to Mariners (7-9), 8-4 | Kingdome (0-1) | 6-10 | Lost 3 |
| » W: Mike Moore (1-2) L: Pete Redfern (1-2) S: Mike Stanton (3) | Seventh | 5 out |
| Friday, April 23 |
| » Defeated Mariners (7-10), 12-4 | Kingdome (1-1) | 7-10 | |
| » W: Roger Erickson (2-2) L: Edwin Nunez (0-1) | Sixth | 5 out |
| Saturday, April 24 |
| » Lost to Mariners (8-10), 3-2 | Kingdome (1-2) | 7-11 | |
| » W: Ed Vande Berg (2-1) L: Ron Davis (1-1) S: Bill Caudill (2) | Seventh | 5 out |
| Sunday, April 25 |
| » Lost to Mariners (9-10), 5-4 | Kingdome (1-3) | 7-12 | Lost 2 |
| » W: Bill Caudill (2-0) L: Terry Felton (0-2) | Seventh | 6½ out |
| Tuesday, April 27 |
| » Lost to Tigers (12-6), 5-2 | Hubert H. Humphrey Metrodome (5-5) | 7-13 | Lost 3 |
| » W: Jack Morris (4-1) L: Darrell Jackson (0-3) | Seventh | 7½ out |
| Wednesday, April 28 |
| » Defeated Tigers (12-7), 4-2 | Hubert H. Humphrey Metrodome (6-5) | 8-13 | |
| » W: Pete Redfern (2-2) L: Dan Petry (2-2) S: Ron Davis (2) | Fifth | 6½ out |
| Friday, April 30 |
| » Defeated Brewers (9-8), 7-4 | Hubert H. Humphrey Metrodome (7-5) | 9-13 | Won 2 |
| » W: Roger Erickson (3-2) L: Moose Haas (1-1) | Fifth | 6 out |
| Saturday, May 1 |
| » Lost to Brewers (10-8), 6-5 | Hubert H. Humphrey Metrodome (7-6) | 9-14 | |
| » W: Pete Vuckovich (3-2) L: Doug Corbett (0-2) S: Rollie Fingers (4) | Sixth | 7 out |
| » Major-league debuts: Randy Bush (Twins) |
| Sunday, May 2 |
| » Lost to Brewers (11-8), 11-4 | Hubert H. Humphrey Metrodome (7-7) | 9-15 | Lost 2 |
| » W: Randy Lerch (2-1) L: Albert Williams (2-1) S: Dwight Bernard (1) | Fifth | 7 out |
| Monday, May 3 |
| » Lost to Red Sox (16-7), 6-2 | Fenway Park (0-1) | 9-16 | Lost 3 |
| » W: Chuck Rainey (2-0) L: Terry Felton (0-3) S: Bob Stanley (1) | Sixth | 8 out |
| Tuesday, May 4 |
| » Lost to Red Sox (17-7), 5-3 | Fenway Park (0-2) | 9-17 | Lost 4 |
| » W: Bruce Hurst (1-0) L: Pete Redfern (2-3) S: Luis Aponte (3) | Sixth | 8 out |
| Wednesday, May 5 |
| » Defeated Red Sox (17-8), 3-2 | Fenway Park (1-2) | 10-17 | |
| » W: Roger Erickson (4-2) L: Mike Torrez (2-2) S: Doug Corbett (3) | Sixth | 7½ out |
| Thursday, May 6 |
| » Lost to Brewers (13-10), 6-3 | County Stadium (0-1) | 10-18 | |
| » W: Pete Vuckovich (4-2) L: Brad Havens (1-1) S: Rollie Fingers (5) | Sixth | 7½ out |
| Friday, May 7 |
| » Lost to Brewers (14-10), 4-1 | County Stadium (0-2) | 10-19 | Lost 2 |
| » W: Randy Lerch (3-1) L: Albert Williams (2-2) S: Jim Slaton (1) | Sixth | 7½ out |
| Saturday, May 8 |
| » Lost to Brewers (15-10), 12-1 | County Stadium (0-3) | 10-20 | Lost 3 |
| » W: Mike Caldwell (2-2) L: Terry Felton (0-4) | Sixth | 8½ out |
| Sunday, May 9 |
| » Lost to Brewers (16-10), 6-2 | County Stadium (0-4) | 10-21 | Lost 4 |
| » W: Jim Slaton (2-0) L: Pete Redfern (2-4) S: Rollie Fingers (6) | Sixth | 9½ out |
| Monday, May 10 |
| » Lost to Red Sox (21-9), 9-5 | Hubert H. Humphrey Metrodome (7-8) | 10-22 | Lost 5 |
| » W: Tom Burgmeier (1-0) L: Roger Erickson (4-3) | Sixth | 10½ out |
| Tuesday, May 11 |
| » Defeated Red Sox (21-10), 10-6 | Hubert H. Humphrey Metrodome (8-8) | 11-22 | |
| » W: Bobby Castillo (1-1) L: Bob Ojeda (1-3) | Sixth | 9½ out |
| Wednesday, May 12 |
| » Lost to Red Sox (22-10), 4-1 | Hubert H. Humphrey Metrodome (8-9) | 11-23 | |
| » W: Dennis Eckersley (4-2) L: Ron Davis (1-2) S: Mark Clear (6) | Sixth | 10½ out |
| Thursday, May 13 |
| » Lost to Tigers (18-12), 6-2 | Tiger Stadium (0-1) | 11-24 | Lost 2 |
| » W: Jack Morris (5-3) L: John Pacella (0-2) | Sixth | 11½ out |
| Friday, May 14 |
| » Lost to Tigers (19-12), 4-2 | Tiger Stadium (0-2) | 11-25 | Lost 3 |
| » W: Dave Rozema (3-0) L: Ron Davis (1-3) | Seventh | 11½ out |
| Saturday, May 15 |
| » Lost to Tigers (20-12), 5-4 | Tiger Stadium (0-3) | 11-26 | Lost 4 |
| » W: Elias Sosa (2-1) L: Darrell Jackson (0-4) | Seventh | 12½ out |
| » Major-league debuts: Pete Filson (Twins) |
| Sunday, May 16 |
| » Lost to Tigers (21-12), 7-6 | Tiger Stadium (0-4) | 11-27 | Lost 5 |
| » W: Dave Tobik (1-0) L: Terry Felton (0-5) | Seventh | 13½ out |
| Tuesday, May 18 |
| » Defeated Orioles (14-20), 8-7 | Memorial Stadium (1-0) | 12-27 | |
| » W: Bobby Castillo (2-1) L: Jim Palmer (1-2) S: Ron Davis (3) | Seventh | 13½ out |
| Wednesday, May 19 |
| » Lost to Orioles (15-20), 4-2 | Memorial Stadium (1-1) | 12-28 | |
| » W: Sammy Stewart (4-2) L: Pete Filson (0-1) S: Tim Stoddard (2) | Seventh | 14½ out |
| Thursday, May 20 |
| » Lost to Orioles (16-20), 6-0 | Memorial Stadium (1-2) | 12-29 | Lost 2 |
| » W: Scott McGregor (5-3) L: Pete Redfern (2-5) | Seventh | 14½ out |
| Friday, May 21 |
| » Lost to Yankees (18-19), 12-1 | Yankee Stadium (0-1) | 12-30 | Lost 3 |
| » W: Rudy May (1-2) L: Brad Havens (1-2) | Seventh | 15½ out |
| » Major-league debuts: Paul Boris (Twins) |
| Saturday, May 22 |
| » Lost to Yankees (19-19), 1-0 | Yankee Stadium (0-2) | 12-31 | Lost 4 |
| » W: Dave Righetti (3-3) L: Darrell Jackson (0-5) S: Rich Gossage (10) | Seventh | 16½ out |
| Sunday, May 23 |
| » Lost to Yankees (20-19), 4-2 | Yankee Stadium (0-3) | 12-32 | Lost 5 |
| » W: Ron Guidry (7-1) L: Bobby Castillo (2-2) S: Rich Gossage (11) | Seventh | 16½ out |
| Monday, May 24 |
| » Lost to Indians (17-23), 9-2 | Hubert H. Humphrey Metrodome (8-10) | 12-33 | Lost 6 |
| » W: Len Barker (5-2) L: Pete Redfern (2-6) | Seventh | 17½ out |
| Tuesday, May 25 |
| » Lost to Indians (18-23), 7-0 | Hubert H. Humphrey Metrodome (8-11) | 12-34 | Lost 7 |
| » W: Lary Sorensen (4-3) L: Brad Havens (1-3) | Seventh | 18 out |
| Future Twin Jason Kubel is born in Belle Fourche, SD. |
| Wednesday, May 26 |
| » Lost to Indians (19-23), 2-1 | Hubert H. Humphrey Metrodome (8-12) | 12-35 | Lost 8 |
| » W: Dan Spillner (3-4) L: Ron Davis (1-4) | Seventh | 18½ out |
| Friday, May 28 |
| » Lost to Yankees (22-20), 10-5 | Hubert H. Humphrey Metrodome (8-13) | 12-36 | Lost 9 |
| » W: Rich Gossage (1-2) L: Ron Davis (1-5) | Seventh | 19 out |
| Saturday, May 29 |
| » Lost to Yankees (23-20), 6-4 | Hubert H. Humphrey Metrodome (8-14) | 12-37 | Lost 10 |
| » W: Shane Rawley (3-1) L: Brad Havens (1-4) | Seventh | 20 out |
| Sunday, May 30 |
| » Lost to Yankees (24-20), 8-6 | Hubert H. Humphrey Metrodome (8-15) | 12-38 | Lost 11 |
| » W: Rich Gossage (2-2) L: Paul Boris (0-1) S: Shane Rawley (3) | Seventh | 20 out |
| Monday, May 31 |
| » Lost to Indians (23-23), 9-4 | Cleveland Stadium (0-1) | 12-39 | Lost 12 |
| » W: Lary Sorensen (5-3) L: Pete Filson (0-2) | Seventh | 20 out |
| Tuesday, June 1 |
| » Lost to Indians (24-23), 6-4 | Cleveland Stadium (0-2) | 12-40 | Lost 13 |
| » W: Ed Glynn (1-0) L: Ron Davis (1-6) S: Dan Spillner (5) | Seventh | 20 out |
| Wednesday, June 2 |
| » Lost to Indians (25-23), 4-2 | Cleveland Stadium (0-3) | 12-41 | Lost 14 |
| » W: Rick Sutcliffe (4-1) L: Bobby Castillo (2-3) S: Ed Whitson (2) | Seventh | 20 out |
| Friday, June 4 |
| » Defeated Orioles (23-26), 6-0 | Hubert H. Humphrey Metrodome (9-15) | 13-41 | |
| » W: Brad Havens (2-4) L: Scott McGregor (6-4) S: Terry Felton (1) | Sixth | 19 out |
| Saturday, June 5 |
| » Lost to Orioles (24-26), 3-1 | Hubert H. Humphrey Metrodome (9-16) | 13-42 | |
| » W: Mike Flanagan (4-4) L: Albert Williams (2-3) | Seventh | 19 out |
| Sunday, June 6 |
| » Lost to Orioles (25-26), 7-5 | Hubert H. Humphrey Metrodome (9-17) | 13-43 | Lost 2 |
| » W: Tim Stoddard (1-2) L: Ron Davis (1-7) | Seventh | 19 out |
| » Major-league debuts: Frank Viola (Twins) |
| Monday, June 7 |
| » Lost to Royals (30-21), 5-4 | Hubert H. Humphrey Metrodome (9-18) | 13-44 | Lost 3 |
| » W: Dan Quisenberry (2-2) L: Pete Redfern (2-7) | Seventh | 20 out |
| Tuesday, June 8 |
| » Lost to Royals (31-21), 9-4 | Hubert H. Humphrey Metrodome (9-19) | 13-45 | Lost 4 |
| » W: Larry Gura (6-2) L: Jack O'Connor (0-1) | Seventh | 21 out |
| Wednesday, June 9 |
| » Lost to Royals (32-21), 8-5 | Hubert H. Humphrey Metrodome (9-20) | 13-46 | Lost 5 |
| » W: Paul Splittorff (5-4) L: Albert Williams (2-4) S: Dan Quisenberry (15) | Seventh | 22 out |
| Thursday, June 10 |
| » Defeated Royals (32-22), 8-7 | Hubert H. Humphrey Metrodome (10-20) | 14-46 | |
| » W: Pete Redfern (3-7) L: Mike Armstrong (2-1) | Seventh | 21 out |
| Saturday, June 12 |
| » Lost to Rangers (18-33), 4-3 | Arlington Stadium (0-1) | 14-47 | |
| » W: Rick Honeycutt (1-7) L: Bobby Castillo (2-4) S: Dave Schmidt (1) | Seventh | 21½ out |
| Sunday, June 13 |
| » Lost to Rangers (19-33), 10-4 | Arlington Stadium (0-2) | 14-48 | Lost 2 |
| » W: Doc Medich (4-5) L: Jack O'Connor (0-2) | Seventh | 22 out |
| Monday, June 14 |
| » Lost to Royals (34-24), 3-0 | Royals Stadium (0-1) | 14-49 | Lost 3 |
| » W: Paul Splittorff (6-4) L: Brad Havens (2-5) S: Dan Quisenberry (16) | Seventh | 22½ out |
| Tuesday, June 15 |
| » Lost to Royals (35-24), 7-4 | Royals Stadium (0-2) | 14-50 | Lost 4 |
| » W: Bud Black (1-1) L: Albert Williams (2-5) S: Dan Quisenberry (17) | Seventh | 23½ out |
| Wednesday, June 16 |
| » Defeated Royals (35-25), 5-2 | Royals Stadium (1-2) | 15-50 | |
| » W: Frank Viola (1-0) L: Vida Blue (4-4) | Seventh | 22½ out |
| Friday, June 18 |
| » Lost to Rangers (22-35), 3-2 | Hubert H. Humphrey Metrodome (10-21) | 15-51 | |
| » W: Doc Medich (5-5) L: Bobby Castillo (2-5) S: Steve Comer (4) | Seventh | 24 out |
| Saturday, June 19 |
| » Lost to Rangers (23-35), 6-3 | Hubert H. Humphrey Metrodome (10-22) | 15-52 | Lost 2 |
| » W: Jon Matlack (2-5) L: Pete Redfern (3-8) S: Danny Darwin (2) | Seventh | 24 out |
| Sunday, June 20 |
| » Defeated Rangers (23-36), 4-1 | Hubert H. Humphrey Metrodome (11-22) | 16-52 | |
| » W: Brad Havens (3-5) L: Frank Tanana (3-8) S: Ron Davis (4) | Seventh | 24 out |
| Monday, June 21 |
| » Lost to White Sox (37-28), 5-4 | Comiskey Park I (0-1) | 16-53 | |
| » W: Salome Barojas (5-1) L: Terry Felton (0-6) | Seventh | 25 out |
| Tuesday, June 22 |
| » Lost to White Sox (38-28), 6-5 | Comiskey Park I (0-2) | 16-54 | Lost 2 |
| » W: Eddie Solomon (3-6) L: Terry Felton (0-7) | Seventh | 25 out |
| Wednesday, June 23 |
| » Defeated White Sox (38-29), 6-3 | Comiskey Park I (1-2) | 17-54 | |
| » W: Paul Boris (1-1) L: Salome Barojas (5-2) S: Ron Davis (5) | Seventh | 25 out |
| Friday, June 25 |
| » Major-league debuts: Ben Hayes (Reds) |
| Saturday, June 26 |
| » Defeated Blue Jays (32-38), 4-3 | Exhibition Stadium (1-0) | 18-54 | Won 2 |
| » W: Ron Davis (2-7) L: Dave Stieb (6-8) | Seventh | 25 out |
| Sunday, June 27 |
| » Lost to Blue Jays (33-38), 3-2 | Exhibition Stadium (1-1) | 18-55 | |
| » W: Joey McLaughlin (7-3) L: Terry Felton (0-8) | Seventh | 26 out |
| Monday, June 28 |
| » Lost to White Sox (40-31), 8-7 | Hubert H. Humphrey Metrodome (11-23) | 18-56 | Lost 2 |
| » W: Dennis Lamp (5-3) L: Albert Williams (2-6) S: Salome Barojas (13) | Sixth | 26½ out |
| Tuesday, June 29 |
| » Defeated White Sox (40-32), 12-5 | Hubert H. Humphrey Metrodome (12-23) | 19-56 | |
| » W: Frank Viola (2-0) L: Richard Dotson (3-8) S: Terry Felton (2) | Seventh | 26½ out |
| Wednesday, June 30 |
| » Defeated White Sox (40-33), 4-3 | Hubert H. Humphrey Metrodome (13-23) | 20-56 | Won 2 |
| » W: Bobby Castillo (3-5) L: La Marr Hoyt (10-6) S: Ron Davis (6) | Seventh | 25½ out |
| Thursday, July 1 |
| » Defeated White Sox (40-34), 9-2 | Hubert H. Humphrey Metrodome (14-23) | 21-56 | Won 3 |
| » W: Pete Redfern (4-8) L: Britt Burns (8-4) | Seventh | 24½ out |
| Friday, July 2 |
| » Lost to Blue Jays (34-41), 9-4 | Hubert H. Humphrey Metrodome (14-24) | 21-57 | |
| » W: Dale Murray (4-3) L: Brad Havens (3-6) S: Joey McLaughlin (3) | Seventh | 24½ out |
| Saturday, July 3 |
| » Defeated Blue Jays (34-42), 2-1 | Hubert H. Humphrey Metrodome (15-24) | 22-57 | |
| » W: Jack O'Connor (1-2) L: Jim Clancy (7-5) | Seventh | 23½ out |
| Sunday, July 4 |
| » Defeated Blue Jays (34-43), 4-3 | Hubert H. Humphrey Metrodome (16-24) | 23-57 | Won 2 |
| » W: Jeff Little (1-0) L: Dave Stieb (6-10) | Seventh | 23 out |
| Monday, July 5 |
| » Defeated Tigers (39-36), 5-3 | Tiger Stadium (1-4) | 24-57 | Won 3 |
| » W: Bobby Castillo (4-5) L: Milt Wilcox (6-5) | Seventh | 22½ out |
| Tuesday, July 6 |
| » Lost to Tigers (40-36), 11-6 | Tiger Stadium (1-5) | 24-58 | |
| » W: Jack Morris (9-9) L: Pete Redfern (4-9) | Seventh | 23½ out |
| Wednesday, July 7 |
| » Defeated Brewers (45-34), 11-8 | County Stadium (1-4) | 25-58 | |
| » W: Brad Havens (4-6) L: Bob McClure (7-3) S: John Pacella (1) | Seventh | 23½ out |
| Thursday, July 8 |
| » Defeated Brewers (45-35), 3-0 | County Stadium (2-4) | 26-58 | Won 2 |
| » W: Jack O'Connor (2-2) L: Pete Vuckovich (10-4) S: Ron Davis (7) | Seventh | 22½ out |
| Friday, July 9 |
| » Defeated Red Sox (48-35), 4-1 | Fenway Park (2-2) | 27-58 | Won 3 |
| » W: Frank Viola (3-0) L: Dennis Eckersley (9-7) | Seventh | 21½ out |
| Saturday, July 10 |
| » Lost to Red Sox (49-35), 5-4 | Fenway Park (2-3) | 27-59 | |
| » W: Bruce Hurst (3-3) L: Bobby Castillo (4-6) S: Bob Stanley (6) | Seventh | 21½ out |
| Sunday, July 11 |
| » Defeated Red Sox (49-36), 7-3 | Fenway Park (3-3) | 28-59 | |
| » W: Brad Havens (5-6) L: Mark Clear (6-4) S: Ron Davis (8) | Seventh | 21½ out |
| Thursday, July 15 |
| » Lost to Tigers (43-41), 18-2 | Hubert H. Humphrey Metrodome (16-25) | 28-60 | |
| » W: Dan Petry (9-6) L: Jack O'Connor (2-3) S: Kevin Saucier (5) | Seventh | 22½ out |
| Friday, July 16 |
| » Lost to Tigers (44-41), 6-3 | Hubert H. Humphrey Metrodome (16-26) | 28-61 | Lost 2 |
| » W: Jack Morris (11-9) L: Frank Viola (3-1) S: Dave Tobik (3) | Seventh | 23½ out |
| Saturday, July 17 |
| » Lost to Tigers (45-41), 8-4 | Hubert H. Humphrey Metrodome (16-27) | 28-62 | Lost 3 |
| » W: Jerry Ujdur (3-5) L: Bobby Castillo (4-7) S: Dave Tobik (4) | Seventh | 23½ out |
| Sunday, July 18 |
| » Defeated Tigers (45-42), 6-1 | Hubert H. Humphrey Metrodome (17-27) | 29-62 | |
| » W: Brad Havens (6-6) L: Pat Underwood (3-6) | Seventh | 22½ out |
| Monday, July 19 |
| » Defeated Brewers (53-36), 6-4 | Hubert H. Humphrey Metrodome (18-27) | 30-62 | Won 2 |
| » W: Albert Williams (3-6) L: Jerry Augustine (1-3) S: John Pacella (2) | Seventh | 22½ out |
| Tuesday, July 20 |
| » Defeated Brewers (53-37), 5-3 | Hubert H. Humphrey Metrodome (19-27) | 31-62 | Won 3 |
| » W: Jack O'Connor (3-3) L: Mike Caldwell (7-9) S: Ron Davis (9) | Seventh | 22½ out |
| Wednesday, July 21 |
| » Lost to Brewers (54-37), 10-4 | Hubert H. Humphrey Metrodome (19-28) | 31-63 | |
| » W: Moose Haas (7-5) L: Frank Viola (3-2) | Seventh | 22½ out |
| Friday, July 23 |
| » Defeated Red Sox (54-39), 8-4 | Hubert H. Humphrey Metrodome (20-28) | 32-63 | |
| » W: Bobby Castillo (5-7) L: Bruce Hurst (3-4) S: Ron Davis (10) | Seventh | 21½ out |
| Saturday, July 24 |
| » Defeated Red Sox (54-40), 5-3 | Hubert H. Humphrey Metrodome (21-28) | 33-63 | Won 2 |
| » W: Brad Havens (7-6) L: Bob Stanley (7-3) S: Ron Davis (11) | Seventh | 20½ out |
| Sunday, July 25 |
| » Lost to Red Sox (55-40), 5-0 | Hubert H. Humphrey Metrodome (21-29) | 33-64 | |
| » W: Mike Torrez (7-5) L: Albert Williams (3-7) | Seventh | 21½ out |
| Monday, July 26 |
| » Defeated Mariners (49-48), 10-4 | Kingdome (2-3) | 34-64 | |
| » W: Jack O'Connor (4-3) L: Floyd Bannister (9-6) | Seventh | 20½ out |
| Tuesday, July 27 |
| » Lost to Mariners (50-48), 9-7 | Kingdome (2-4) | 34-65 | |
| » W: Bryan Clark (2-0) L: John Pacella (0-3) S: Bill Caudill (18) | Seventh | 21½ out |
| Wednesday, July 28 |
| » Lost to Mariners (51-48), 6-2 | Kingdome (2-5) | 34-66 | Lost 2 |
| » W: Gaylord Perry (7-8) L: Bobby Castillo (5-8) S: Mike Stanton (6) | Seventh | 22½ out |
| Thursday, July 29 |
| » Lost to Athletics (42-60), 5-0 | Oakland-Alameda County Stadium (1-3) | 34-67 | Lost 3 |
| » W: Rick Langford (8-11) L: Brad Havens (7-7) | Seventh | 23½ out |
| Friday, July 30 |
| » Lost to Athletics (43-60), 4-3 | Oakland-Alameda County Stadium (1-4) | 34-68 | Lost 4 |
| » W: Brian Kingman (2-8) L: Ron Davis (2-8) | Seventh | 24½ out |
| Saturday, July 31 |
| » Lost to Athletics (44-60), 3-2 | Oakland-Alameda County Stadium (1-5) | 34-69 | Lost 5 |
| » W: Tom Underwood (7-4) L: Terry Felton (0-9) | Seventh | 24½ out |
| Sunday, August 1 |
| » Defeated Athletics (44-61), 8-7 | Oakland-Alameda County Stadium (2-5) | 35-69 | |
| » W: John Pacella (1-3) L: Dave Beard (6-8) S: Ron Davis (12) | Seventh | 24½ out |
| Monday, August 2 |
| » Defeated Angels (59-45), 9-7 | Anaheim Stadium (1-3) | 36-69 | Won 2 |
| » W: Jeff Little (2-0) L: Luis Sanchez (3-2) S: Ron Davis (13) | Seventh | 23½ out |
| Tuesday, August 3 |
| » Defeated Angels (59-46), 5-4 | Anaheim Stadium (2-3) | 37-69 | Won 3 |
| » W: Brad Havens (8-7) L: Steve Renko (9-3) S: Terry Felton (3) | Seventh | 23½ out |
| Wednesday, August 4 |
| » Lost to Angels (60-46), 8-6 | Anaheim Stadium (2-4) | 37-70 | |
| » W: Dave Goltz (6-4) L: Terry Felton (0-10) | Seventh | 23½ out |
| Thursday, August 5 |
| » Defeated Angels (60-47), 8-6 | Anaheim Stadium (3-4) | 38-70 | |
| » W: Jack O'Connor (5-3) L: Luis Tiant (0-1) S: Ron Davis (14) | Seventh | 22½ out |
| Friday, August 6 |
| » Lost to Athletics (47-63), 4-1 | Hubert H. Humphrey Metrodome (21-30) | 38-71 | |
| » W: Mike Norris (6-6) L: Frank Viola (3-3) S: Tom Underwood (4) | Seventh | 24 out |
| Saturday, August 7 |
| » Lost to Athletics (48-63), 7-1 | Hubert H. Humphrey Metrodome (21-31) | 38-72 | Lost 2 |
| » W: Matt Keough (9-15) L: Bobby Castillo (5-9) | Seventh | 24½ out |
| Sunday, August 8 |
| » Lost to Athletics (49-63), 5-2 | Hubert H. Humphrey Metrodome (21-32) | 38-73 | Lost 3 |
| » W: Tom Underwood (8-4) L: Brad Havens (8-8) | Seventh | 25½ out |
| Tuesday, August 10 |
| » Defeated Angels (63-48), 5-2 | Hubert H. Humphrey Metrodome (22-32) | 39-73 | |
| » W: Pete Redfern (5-9) L: Ken Forsch (10-8) S: Ron Davis (15) | Sixth | 24½ out |
| Wednesday, August 11 |
| » Lost to Angels (64-48), 6-3 | Hubert H. Humphrey Metrodome (22-33) | 39-74 | |
| » W: Geoff Zahn (12-5) L: Terry Felton (0-11) S: Dave Goltz (1) | Sixth | 25½ out |
| Thursday, August 12 |
| » Lost to Angels (65-48), 3-1 | Hubert H. Humphrey Metrodome (22-34) | 39-75 | Lost 2 |
| » W: Luis Tiant (1-1) L: Frank Viola (3-4) S: Luis Sanchez (3) | Seventh | 26½ out |
| Friday, August 13 |
| » Defeated Mariners (56-58), 3-1 | Hubert H. Humphrey Metrodome (23-34) | 40-75 | |
| » W: Bobby Castillo (6-9) L: Gaylord Perry (7-10) | Seventh | 26½ out |
| Saturday, August 14 |
| » Lost to Mariners (57-58), 3-1 | Hubert H. Humphrey Metrodome (23-35) | 40-76 | |
| » W: Mike Stanton (2-3) L: Brad Havens (8-9) S: Bill Caudill (21) | Seventh | 26½ out |
| Sunday, August 15 |
| » Lost to Mariners (58-58), 10-2 | Hubert H. Humphrey Metrodome (23-36) | 40-77 | Lost 2 |
| » W: Jim Beattie (8-9) L: Terry Felton (0-12) | Seventh | 27 out |
| Tuesday, August 17 |
| » Lost to Orioles (61-55), 8-4 | Hubert H. Humphrey Metrodome (23-37) | 40-78 | Lost 3 |
| » W: Mike Flanagan (9-10) L: Jack O'Connor (5-4) | Seventh | 28 out |
| Wednesday, August 18 |
| » Defeated Orioles (61-56), 6-5 | Hubert H. Humphrey Metrodome (24-37) | 41-78 | |
| » W: Ron Davis (3-8) L: Tim Stoddard (2-4) | Seventh | 27 out |
| Thursday, August 19 |
| » Defeated Orioles (61-57), 9-3 | Hubert H. Humphrey Metrodome (25-37) | 42-78 | Won 2 |
| » W: Bobby Castillo (7-9) L: Scott McGregor (12-12) | Seventh | 27 out |
| Friday, August 20 |
| » Lost to Indians (58-59), 7-5 | Cleveland Stadium (0-4) | 42-79 | |
| » W: Len Barker (12-8) L: Pete Redfern (5-10) S: Dan Spillner (16) | Sixth | 27 out |
| Saturday, August 21 |
| » Defeated Indians (58-60), 4-3 | Cleveland Stadium (1-4) | 43-79 | |
| » W: Albert Williams (4-7) L: Lary Sorensen (10-9) S: Ron Davis (16) | Sixth | 27 out |
| Sunday, August 22 |
| » Lost to Indians (59-60), 4-3 | Cleveland Stadium (1-5) | 43-80 | |
| » W: Rick Sutcliffe (11-4) L: Jack O'Connor (5-5) | Seventh | 28 out |
| Tuesday, August 24 |
| » Defeated Yankees (62-61), 5-0 | Yankee Stadium (1-3) | 44-80 | |
| » W: Frank Viola (4-4) L: Tommy John (9-10) | Seventh | 27½ out |
| Wednesday, August 25 |
| » Lost to Yankees (63-61), 8-1 | Yankee Stadium (1-4) | 44-81 | |
| » W: Shane Rawley (8-8) L: Bobby Castillo (7-10) | Seventh | 28 out |
| Thursday, August 26 |
| » Lost to Yankees (64-61), 7-2 | Yankee Stadium (1-5) | 44-82 | Lost 2 |
| » W: Ron Guidry (12-5) L: Brad Havens (8-10) | Sixth | 28½ out |
| Friday, August 27 |
| » Defeated Indians (61-62), 5-3 | Hubert H. Humphrey Metrodome (26-37) | 45-82 | |
| » W: Albert Williams (5-7) L: Lary Sorensen (10-10) S: Ron Davis (17) | Sixth | 28½ out |
| Saturday, August 28 |
| » Defeated Indians (61-63), 10-0 | Hubert H. Humphrey Metrodome (27-37) | 46-82 | Won 2 |
| » W: Jack O'Connor (6-5) L: Rick Sutcliffe (11-5) | Seventh | 28½ out |
| Sunday, August 29 |
| » Defeated Indians (61-64), 6-3 | Hubert H. Humphrey Metrodome (28-37) | 47-82 | Won 3 |
| » W: Bobby Castillo (8-10) L: Dan Spillner (10-8) | Seventh | 28½ out |
| Monday, August 30 |
| » Lost to Yankees (66-63), 8-2 | Hubert H. Humphrey Metrodome (28-38) | 47-83 | |
| » W: Shane Rawley (9-8) L: Frank Viola (4-5) | Seventh | 29½ out |
| Tuesday, August 31 |
| » Lost to Yankees (67-63), 3-1 | Hubert H. Humphrey Metrodome (28-39) | 47-84 | Lost 2 |
| » W: Ron Guidry (13-5) L: Brad Havens (8-11) | Seventh | 29½ out |
| Wednesday, September 1 |
| » Defeated Yankees (67-64), 7-2 | Hubert H. Humphrey Metrodome (29-39) | 48-84 | |
| » W: Albert Williams (6-7) L: Dave Righetti (8-7) | Seventh | 28½ out |
| Friday, September 3 |
| » Lost to Orioles (74-58), 4-2 | Memorial Stadium (1-3) | 48-85 | |
| » W: Mike Flanagan (12-10) L: Jack O'Connor (6-6) | Seventh | 29½ out |
| Saturday, September 4 |
| » Lost to Orioles (75-58), 3-0 | Memorial Stadium (1-4) | 48-86 | Lost 2 |
| » W: Jim Palmer (13-3) L: Bobby Castillo (8-11) | Seventh | 29½ out |
| Sunday, September 5 |
| » Lost to Orioles (76-58), 5-4 | Memorial Stadium (1-5) | 48-87 | Lost 3 |
| » W: Storm Davis (6-3) L: Pete Redfern (5-11) | Seventh | 29½ out |
| Monday, September 6 |
| » Lost to Rangers (54-82), 4-3 | Arlington Stadium (0-3) | 48-88 | Lost 4 |
| » W: Mike Smithson (2-1) L: Brad Havens (8-12) S: Danny Darwin (7) | Seventh | 30 out |
| » Lost to Rangers (55-82), 11-7 | Arlington Stadium (0-4) | 48-89 | Lost 5 |
| » W: Charlie Hough (13-11) L: Don Cooper (0-1) | Seventh | 30 out |
| » Major-league debuts: Nick Capra (Rangers) |
| Tuesday, September 7 |
| » Defeated Rangers (55-83), 8-1 | Arlington Stadium (1-4) | 49-89 | |
| » W: Albert Williams (7-7) L: Steve Comer (1-6) S: Ron Davis (18) | Seventh | 29 out |
| Wednesday, September 8 |
| » Lost to Rangers (56-83), 2-0 | Arlington Stadium (1-5) | 49-90 | |
| » W: Jon Matlack (7-6) L: Jack O'Connor (6-7) S: Paul Mirabella (3) | Seventh | 30 out |
| Friday, September 10 |
| » Defeated Royals (79-61), 5-0 | Royals Stadium (2-2) | 50-90 | |
| » W: Bobby Castillo (9-11) L: Larry Gura (17-10) | Seventh | 29 out |
| Saturday, September 11 |
| » Lost to Royals (80-61), 9-3 | Royals Stadium (2-3) | 50-91 | |
| » W: Dennis Leonard (10-4) L: Frank Viola (4-6) | Seventh | 30 out |
| Sunday, September 12 |
| » Lost to Royals (81-61), 18-7 | Royals Stadium (2-4) | 50-92 | Lost 2 |
| » W: Bob Tufts (1-0) L: Terry Felton (0-13) S: Dan Quisenberry (33) | Seventh | 31 out |
| » Major-league debuts: Buddy Biancalana (Royals) |
| Monday, September 13 |
| » Defeated Rangers (57-86), 2-0 | Hubert H. Humphrey Metrodome (30-39) | 51-92 | |
| » W: Albert Williams (8-7) L: Mike Mason (0-1) S: Ron Davis (19) | Seventh | 31 out |
| » Major-league debuts: Mike Mason (Rangers) |
| Tuesday, September 14 |
| » Defeated Rangers (57-87), 3-2 | Hubert H. Humphrey Metrodome (31-39) | 52-92 | Won 2 |
| » W: Jack O'Connor (7-7) L: Jon Matlack (7-7) | Seventh | 31 out |
| Wednesday, September 15 |
| » Defeated Rangers (57-88), 10-2 | Hubert H. Humphrey Metrodome (32-39) | 53-92 | Won 3 |
| » W: Bobby Castillo (10-11) L: Frank Tanana (6-18) | Seventh | 31 out |
| Thursday, September 16 |
| » Lost to Rangers (58-88), 8-2 | Hubert H. Humphrey Metrodome (32-40) | 53-93 | |
| » W: Charlie Hough (15-11) L: Frank Viola (4-7) | Seventh | 31 out |
| Friday, September 17 |
| » Defeated Royals (84-63), 5-4 | Hubert H. Humphrey Metrodome (33-40) | 54-93 | |
| » W: Brad Havens (9-12) L: Paul Splittorff (9-10) S: Ron Davis (20) | Seventh | 30 out |
| Saturday, September 18 |
| » Defeated Royals (84-64), 11-5 | Hubert H. Humphrey Metrodome (34-40) | 55-93 | Won 2 |
| » W: Albert Williams (9-7) L: Vida Blue (13-10) | Seventh | 29 out |
| Sunday, September 19 |
| » Defeated Royals (84-65), 9-4 | Hubert H. Humphrey Metrodome (35-40) | 56-93 | Won 3 |
| » W: Jack O'Connor (8-7) L: Bill Castro (2-2) | Sixth | 28 out |
| Monday, September 20 |
| » Defeated Blue Jays (69-81), 4-1 | Hubert H. Humphrey Metrodome (36-40 |
