| Wednesday, January 6 |
| Former Red Wally Post dies in St.Henry, OH at the age of 53. |
| Saturday, January 23 |
| Future Red Wily Mo Pena is born in Laguna Salada, D.R. |
| Monday, April 5 |
| » Lost to Cubs (1-0), 3-2 | Riverfront Stadium (0-1) | 0-1 | |
| » W: Doug Bird (1-0) L: Mario Soto (0-1) S: Willie Hernandez (1) | Second | ½ out |
| Wednesday, April 7 |
| » Defeated Cubs (1-1), 6-2 | Riverfront Stadium (1-1) | 1-1 | |
| » W: Bruce Berenyi (1-0) L: Dickie Noles (0-1) S: Tom Hume (1) | Second | 1 out |
| Friday, April 9 |
| » Defeated Giants (0-3), 7-0 | Riverfront Stadium (2-1) | 2-1 | Won 2 |
| » W: Frank Pastore (1-0) L: Dan Schatzeder (0-1) | Second | 1 out |
| Saturday, April 10 |
| » Lost to Giants (1-3), 7-5 | Riverfront Stadium (2-2) | 2-2 | |
| » W: Greg Minton (1-0) L: Tom Hume (0-1) S: Jim Barr (1) | Third | 2 out |
| Sunday, April 11 |
| » Lost to Giants (2-3), 6-1 | Riverfront Stadium (2-3) | 2-3 | Lost 2 |
| » W: Al Holland (1-0) L: Charlie Leibrandt (0-1) | Third | 3 out |
| Monday, April 12 |
| » Lost to Braves (6-0), 6-1 | Riverfront Stadium (2-4) | 2-4 | Lost 3 |
| » W: Bob Walk (2-0) L: Bruce Berenyi (1-1) | Fifth | 4 out |
| Tuesday, April 13 |
| » Lost to Braves (7-0), 8-5 | Riverfront Stadium (2-5) | 2-5 | Lost 4 |
| » W: Gene Garber (1-0) L: Jim Kern (0-1) | Fifth | 5 out |
| » Major-league debuts: Joe Cowley (Braves) |
| Wednesday, April 14 |
| » Lost to Braves (8-0), 5-2 | Riverfront Stadium (2-6) | 2-6 | Lost 5 |
| » W: Rick Camp (1-0) L: Jim Kern (0-2) | Sixth | 6 out |
| Friday, April 16 |
| » Lost to Giants (4-4), 6-1 | Candlestick Park (0-1) | 2-7 | Lost 6 |
| » W: Rich Gale (1-0) L: Mario Soto (0-2) | Fifth | 7 out |
| Saturday, April 17 |
| » Defeated Giants (4-5), 8-2 | Candlestick Park (1-1) | 3-7 | |
| » W: Bruce Berenyi (2-1) L: Al Holland (1-1) S: Tom Hume (2) | Sixth | 7 out |
| Sunday, April 18 |
| » Lost to Giants (5-5), 4-2 | Candlestick Park (1-2) | 3-8 | |
| » W: Alan Fowlkes (2-0) L: Tom Seaver (0-1) S: Greg Minton (2) | Sixth | 8 out |
| Tuesday, April 20 |
| » Lost to Braves (12-0), 4-2 | Atlanta-Fulton County Stadium (0-1) | 3-9 | Lost 2 |
| » W: Steve Bedrosian (1-0) L: Frank Pastore (1-1) S: Gene Garber (3) | Sixth | 9 out |
| Wednesday, April 21 |
| » Lost to Braves (13-0), 4-3 | Atlanta-Fulton County Stadium (0-2) | 3-10 | Lost 3 |
| » W: Rick Camp (2-0) L: Bob Shirley (0-1) | Sixth | 10 out |
| Thursday, April 22 |
| » Defeated Braves (13-1), 2-1 | Atlanta-Fulton County Stadium (1-2) | 4-10 | |
| » W: Bruce Berenyi (3-1) L: Bob Walk (2-1) S: Tom Hume (3) | Sixth | 9 out |
| Friday, April 23 |
| » Lost to Astros (6-10), 7-3 | Astrodome (0-1) | 4-11 | |
| » W: Joe Niekro (2-1) L: Tom Seaver (0-2) | Sixth | 9 out |
| Saturday, April 24 |
| » Defeated Astros (6-11), 3-2 | Astrodome (1-1) | 5-11 | |
| » W: Frank Pastore (2-1) L: Bob Knepper (1-2) S: Tom Hume (4) | Sixth | 8 out |
| Sunday, April 25 |
| » Defeated Astros (6-12), 4-3 | Astrodome (2-1) | 6-11 | Won 2 |
| » W: Bob Shirley (1-1) L: Randy Moffitt (0-1) S: Tom Hume (5) | Fifth | 7½ out |
| Tuesday, April 27 |
| » Defeated Cubs (6-12), 6-3 | Wrigley Field (1-0) | 7-11 | Won 3 |
| » W: Bruce Berenyi (4-1) L: Dan Larson (0-2) S: Jim Kern (1) | Fifth | 6 out |
| Wednesday, April 28 |
| » Lost to Cubs (7-12), 6-0 | Wrigley Field (1-1) | 7-12 | |
| » W: Dickie Noles (3-2) L: Tom Seaver (0-3) | Sixth | 7 out |
| Friday, April 30 |
| » Defeated Cardinals (14-7), 8-2 | Riverfront Stadium (3-6) | 8-12 | |
| » W: Frank Pastore (3-1) L: Joaquin Andujar (2-2) | Fifth | 7½ out |
| Saturday, May 1 |
| » Defeated Cardinals (14-8), 10-1 | Riverfront Stadium (4-6) | 9-12 | Won 2 |
| » W: Mario Soto (1-2) L: Andy Rincon (1-2) | Fifth | 6½ out |
| Sunday, May 2 |
| » Defeated Cardinals (14-9), 5-1 | Riverfront Stadium (5-6) | 10-12 | Won 3 |
| » W: Charlie Leibrandt (1-1) L: Steve Mura (2-2) | Fifth | 7 out |
| » Lost to Cardinals (15-9), 6-4 | Riverfront Stadium (5-7) | 10-13 | |
| » W: John Martin (3-2) L: Joe Price (0-1) S: Bruce Sutter (8) | Fifth | 7 out |
| Tuesday, May 4 |
| » Defeated Astros (11-15), 5-2 | Riverfront Stadium (6-7) | 11-13 | |
| » W: Tom Seaver (1-3) L: Bob Knepper (1-3) S: Tom Hume (6) | Fourth | 6½ out |
| Wednesday, May 5 |
| » Lost to Astros (12-15), 8-7 | Riverfront Stadium (6-8) | 11-14 | |
| » W: Don Sutton (4-1) L: Frank Pastore (3-2) S: Dave Smith (4) | Fifth | 6½ out |
| Friday, May 7 |
| » Defeated Pirates (10-14), 5-0 | Riverfront Stadium (7-8) | 12-14 | |
| » W: Mario Soto (2-2) L: Paul Moskau (0-2) | Fourth | 6½ out |
| Saturday, May 8 |
| » Lost to Pirates (11-14), 4-2 | Riverfront Stadium (7-9) | 12-15 | |
| » W: Manny Sarmiento (1-0) L: Bob Shirley (1-2) | Fifth | 6½ out |
| Sunday, May 9 |
| » Lost to Pirates (12-14), 6-3 | Riverfront Stadium (7-10) | 12-16 | Lost 2 |
| » W: Don Robinson (3-0) L: Tom Seaver (1-4) S: Kent Tekulve (3) | Fifth | 7½ out |
| Monday, May 10 |
| » Defeated Cardinals (19-12), 3-1 | Busch Stadium II (1-0) | 13-16 | |
| » W: Frank Pastore (4-2) L: John Martin (3-4) S: Tom Hume (7) | Fourth | 7 out |
| » Major-league debuts: Willie McGee (Cardinals) |
| Tuesday, May 11 |
| » Lost to Cardinals (20-12), 5-1 | Busch Stadium II (1-1) | 13-17 | |
| » W: Steve Mura (3-2) L: Mario Soto (2-3) S: Doug Bair (1) | Sixth | 7 out |
| Thursday, May 13 |
| » Defeated Pirates (12-17), 2-1 | Three Rivers Stadium (1-0) | 14-17 | |
| » W: Joe Price (1-1) L: Rod Scurry (1-2) S: Tom Hume (8) | Fifth | 6½ out |
| Friday, May 14 |
| » Lost to Pirates (13-17), 8-7 | Three Rivers Stadium (1-1) | 14-18 | |
| » W: Enrique Romo (3-1) L: Jim Kern (0-3) S: Kent Tekulve (4) | Fifth | 7½ out |
| Saturday, May 15 |
| » Lost to Pirates (14-17), 12-9 | Three Rivers Stadium (1-2) | 14-19 | Lost 2 |
| » W: Rick Rhoden (2-4) L: Frank Pastore (4-3) | Fifth | 7½ out |
| Sunday, May 16 |
| » Defeated Pirates (14-18), 3-1 | Three Rivers Stadium (2-2) | 15-19 | |
| » W: Mario Soto (3-3) L: Eddie Solomon (1-4) | Fourth | 7½ out |
| Monday, May 17 |
| » Defeated Mets (19-17), 7-2 | Shea Stadium (1-0) | 16-19 | Won 2 |
| » W: Charlie Leibrandt (2-1) L: Pete Falcone (3-1) | Fourth | 6½ out |
| Tuesday, May 18 |
| » Lost to Mets (20-17), 7-4 | Shea Stadium (1-1) | 16-20 | |
| » W: Randy Jones (5-2) L: Bruce Berenyi (4-2) S: Neil Allen (10) | Fifth | 7½ out |
| Wednesday, May 19 |
| » Lost to Mets (21-17), 4-2 | Shea Stadium (1-2) | 16-21 | Lost 2 |
| » W: Pat Zachry (3-1) L: Tom Seaver (1-5) | Fifth | 8½ out |
| Friday, May 21 |
| » Lost to Expos (17-19), 2-0 | Riverfront Stadium (7-11) | 16-22 | Lost 3 |
| » W: Charlie Lea (2-2) L: Mario Soto (3-4) S: Woodie Fryman (2) | Fifth | 9½ out |
| Saturday, May 22 |
| » Lost to Expos (18-19), 4-2 | Riverfront Stadium (7-12) | 16-23 | Lost 4 |
| » W: Scott Sanderson (4-3) L: Frank Pastore (4-4) S: Woodie Fryman (3) | Sixth | 9½ out |
| Sunday, May 23 |
| » Lost to Expos (19-19), 4-2 | Riverfront Stadium (7-13) | 16-24 | Lost 5 |
| » W: Steve Rogers (6-3) L: Bruce Berenyi (4-3) S: Jeff Reardon (7) | Sixth | 9½ out |
| Monday, May 24 |
| » Lost to Phillies (22-19), 9-1 | Riverfront Stadium (7-14) | 16-25 | Lost 6 |
| » W: Steve Carlton (5-6) L: Tom Seaver (1-6) | Sixth | 9½ out |
| Tuesday, May 25 |
| » Defeated Phillies (22-20), 4-3 | Riverfront Stadium (8-14) | 17-25 | |
| » W: Greg Harris (1-0) L: Ed Farmer (1-3) S: Tom Hume (9) | Sixth | 9½ out |
| » Major-league debuts: Duane Walker (Reds) |
| Wednesday, May 26 |
| » Defeated Phillies (22-21), 2-0 | Riverfront Stadium (9-14) | 18-25 | Won 2 |
| » W: Mario Soto (4-4) L: Mike Krukow (4-3) | Fifth | 8½ out |
| Friday, May 28 |
| » Lost to Expos (23-19), 4-2 | Stade Olympique (0-1) | 18-26 | |
| » W: Scott Sanderson (5-3) L: Bruce Berenyi (4-4) | Sixth | 9 out |
| Saturday, May 29 |
| » Lost to Expos (24-19), 4-1 | Stade Olympique (0-2) | 18-27 | Lost 2 |
| » W: Steve Rogers (7-3) L: Joe Price (1-2) | Sixth | 9 out |
| Sunday, May 30 |
| » Defeated Expos (24-20), 7-3 | Stade Olympique (1-2) | 19-27 | |
| » W: Bob Shirley (2-2) L: Bill Gullickson (3-4) S: Charlie Leibrandt (1) | Sixth | 8 out |
| Monday, May 31 |
| » Lost to Phillies (25-21), 5-4 | Veteran's Stadium (0-1) | 19-28 | |
| » W: Sid Monge (2-0) L: Bob Shirley (2-3) | Sixth | 8 out |
| Tuesday, June 1 |
| » Defeated Phillies (25-22), 4-1 | Veteran's Stadium (1-1) | 20-28 | |
| » W: Greg Harris (2-0) L: Mike Krukow (4-4) | Sixth | 8 out |
| Wednesday, June 2 |
| » Lost to Phillies (26-22), 4-2 | Veteran's Stadium (1-2) | 20-29 | |
| » W: Dick Ruthven (5-3) L: Bruce Berenyi (4-5) S: Warren Brusstar (2) | Sixth | 9 out |
| Friday, June 4 |
| » Defeated Mets (27-24), 8-3 | Riverfront Stadium (10-14) | 21-29 | |
| » W: Tom Seaver (2-6) L: Mike Scott (4-5) | Sixth | 8½ out |
| Saturday, June 5 |
| » Defeated Mets (27-25), 6-2 | Riverfront Stadium (11-14) | 22-29 | Won 2 |
| » W: Mario Soto (5-4) L: Charlie Puleo (5-3) | Sixth | 8½ out |
| Sunday, June 6 |
| » Lost to Mets (28-25), 6-3 | Riverfront Stadium (11-15) | 22-30 | |
| » W: Craig Swan (4-1) L: Frank Pastore (4-5) S: Neil Allen (14) | Sixth | 8½ out |
| Monday, June 7 |
| » Lost to Padres (29-22), 6-5 | San Diego/Jack Murphy Stadium (0-1) | 22-31 | Lost 2 |
| » W: Chris Welsh (4-1) L: Greg Harris (2-1) S: Luis DeLeon (3) | Sixth | 9½ out |
| Tuesday, June 8 |
| » Lost to Padres (30-22), 4-1 | San Diego/Jack Murphy Stadium (0-2) | 22-32 | Lost 3 |
| » W: John Montefusco (4-4) L: Bruce Berenyi (4-6) S: Luis DeLeon (4) | Sixth | 10½ out |
| Wednesday, June 9 |
| » Defeated Padres (30-23), 4-3 | San Diego/Jack Murphy Stadium (1-2) | 23-32 | |
| » W: Tom Seaver (3-6) L: Juan Eichelberger (5-7) S: Tom Hume (10) | Sixth | 10½ out |
| Thursday, June 10 |
| » Defeated Dodgers (27-31), 3-2 | Dodger Stadium (1-0) | 24-32 | Won 2 |
| » W: Jim Kern (1-3) L: Fernando Valenzuela (8-5) S: Tom Hume (11) | Sixth | 10 out |
| Friday, June 11 |
| » Lost to Dodgers (28-31), 11-1 | Dodger Stadium (1-1) | 24-33 | |
| » W: Jerry Reuss (6-5) L: Frank Pastore (4-6) | Sixth | 11 out |
| Saturday, June 12 |
| » Lost to Dodgers (29-31), 4-3 | Dodger Stadium (1-2) | 24-34 | Lost 2 |
| » W: Bob Welch (6-4) L: Greg Harris (2-2) S: Steve Howe (2) | Sixth | 12 out |
| Sunday, June 13 |
| » Defeated Dodgers (29-32), 4-2 | Dodger Stadium (2-2) | 25-34 | |
| » W: Bruce Berenyi (5-6) L: Burt Hooton (1-4) S: Tom Hume (12) | Fifth | 11½ out |
| Tuesday, June 15 |
| » Lost to Giants (28-34), 4-3 | Riverfront Stadium (11-16) | 25-35 | |
| » W: Bill Laskey (5-4) L: Tom Seaver (3-7) S: Gary Lavelle (4) | Sixth | 12 out |
| Wednesday, June 16 |
| » Defeated Giants (28-35), 7-3 | Riverfront Stadium (12-16) | 26-35 | |
| » W: Mario Soto (6-4) L: Jim Barr (1-2) S: Tom Hume (13) | Fifth | 12 out |
| Thursday, June 17 |
| » Defeated Giants (28-36), 4-2 | Riverfront Stadium (13-16) | 27-35 | Won 2 |
| » W: Charlie Leibrandt (3-1) L: Rich Gale (2-6) S: Tom Hume (14) | Fifth | 11½ out |
| Friday, June 18 |
| » Lost to Dodgers (33-32), 3-2 | Riverfront Stadium (13-17) | 27-36 | |
| » W: Terry Forster (2-3) L: Tom Hume (0-2) S: Vicente Romo (1) | Fifth | 12½ out |
| Saturday, June 19 |
| » Lost to Dodgers (34-32), 2-1 | Riverfront Stadium (13-18) | 27-37 | Lost 2 |
| » W: Fernando Valenzuela (9-5) L: Bruce Berenyi (5-7) | Fifth | 12½ out |
| Sunday, June 20 |
| » Lost to Dodgers (35-32), 4-2 | Riverfront Stadium (13-19) | 27-38 | Lost 3 |
| » W: Jerry Reuss (8-5) L: Tom Seaver (3-8) S: Steve Howe (3) | Sixth | 12½ out |
| Monday, June 21 |
| » Defeated Dodgers (35-33), 10-2 | Riverfront Stadium (14-19) | 28-38 | |
| » W: Mario Soto (7-4) L: Bob Welch (7-5) | Fifth | 12½ out |
| Tuesday, June 22 |
| » Defeated Padres (36-29), 7-5 | Riverfront Stadium (15-19) | 29-38 | Won 2 |
| » W: Joe Price (2-2) L: Gary Lucas (0-5) S: Tom Hume (15) | Fifth | 11½ out |
| Wednesday, June 23 |
| » Defeated Padres (36-30), 5-4 | Riverfront Stadium (16-19) | 30-38 | Won 3 |
| » W: Tom Hume (1-2) L: Eric Show (4-3) | Fifth | 11½ out |
| Thursday, June 24 |
| » Lost to Padres (37-30), 7-6 | Riverfront Stadium (16-20) | 30-39 | |
| » W: Eric Show (5-3) L: Bob Shirley (2-4) | Fifth | 11½ out |
| Friday, June 25 |
| » Lost to Braves (42-27), 5-2 | Riverfront Stadium (16-21) | 30-40 | Lost 2 |
| » W: Phil Niekro (6-2) L: Bruce Berenyi (5-8) S: Gene Garber (12) | Fifth | 12½ out |
| » Major-league debuts: Ben Hayes (Reds) |
| Saturday, June 26 |
| » Defeated Braves (42-28), 2-1 | Riverfront Stadium (17-21) | 31-40 | |
| » W: Tom Seaver (4-8) L: Ken Dayley (3-4) S: Tom Hume (16) | Fifth | 11½ out |
| Sunday, June 27 |
| » Lost to Braves (43-28), 2-0 | Riverfront Stadium (17-22) | 31-41 | |
| » W: Gene Garber (6-3) L: Tom Hume (1-3) S: Al Hrabosky (3) | Fifth | 12½ out |
| Monday, June 28 |
| » Lost to Giants (33-42), 7-1 | Candlestick Park (1-3) | 31-42 | Lost 2 |
| » W: Renie Martin (3-4) L: Charlie Leibrandt (3-2) | Fifth | 12½ out |
| Tuesday, June 29 |
| » Lost to Giants (34-42), 3-0 | Candlestick Park (1-4) | 31-43 | Lost 3 |
| » W: Atlee Hammaker (5-4) L: Bob Shirley (2-5) | Fifth | 13½ out |
| Wednesday, June 30 |
| » Lost to Giants (35-42), 7-6 | Candlestick Park (1-5) | 31-44 | Lost 4 |
| » W: Greg Minton (4-4) L: Charlie Leibrandt (3-3) | Fifth | 14½ out |
| Friday, July 2 |
| » Lost to Braves (46-29), 6-4 | Atlanta-Fulton County Stadium (1-3) | 31-45 | Lost 5 |
| » W: Ken Dayley (4-4) L: Tom Seaver (4-9) S: Gene Garber (13) | Sixth | 15½ out |
| Saturday, July 3 |
| » Lost to Braves (47-29), 4-2 | Atlanta-Fulton County Stadium (1-4) | 31-46 | Lost 6 |
| » W: Rick Mahler (8-6) L: Mario Soto (7-5) S: Gene Garber (14) | Sixth | 16½ out |
| Sunday, July 4 |
| » Lost to Braves (48-29), 4-1 | Atlanta-Fulton County Stadium (1-5) | 31-47 | Lost 7 |
| » W: Bob Walk (7-6) L: Bob Shirley (2-6) S: Steve Bedrosian (4) | Sixth | 17½ out |
| Monday, July 5 |
| » Lost to Cardinals (45-36), 6-5 | Riverfront Stadium (17-23) | 31-48 | Lost 8 |
| » W: Jim Kaat (3-1) L: Tom Hume (1-4) S: Doug Bair (3) | Sixth | 18½ out |
| Tuesday, July 6 |
| » Lost to Cardinals (46-36), 3-1 | Riverfront Stadium (17-24) | 31-49 | Lost 9 |
| » W: Steve Mura (6-7) L: Charlie Leibrandt (3-4) | Sixth | 18½ out |
| Wednesday, July 7 |
| » Defeated Pirates (41-39), 6-3 | Three Rivers Stadium (3-2) | 32-49 | |
| » W: Tom Hume (2-4) L: Kent Tekulve (5-3) S: Greg Harris (1) | Sixth | 18½ out |
| Thursday, July 8 |
| » Lost to Pirates (42-39), 9-8 | Three Rivers Stadium (3-3) | 32-50 | |
| » W: Kent Tekulve (6-3) L: Joe Price (2-3) | Sixth | 18½ out |
| Friday, July 9 |
| » Lost to Cubs (34-52), 12-0 | Wrigley Field (1-2) | 32-51 | Lost 2 |
| » W: Fergie Jenkins (6-9) L: Bob Shirley (2-7) | Sixth | 19½ out |
| Saturday, July 10 |
| » Lost to Cubs (35-52), 1-0 | Wrigley Field (1-3) | 32-52 | Lost 3 |
| » W: Dickie Noles (6-7) L: Bruce Berenyi (5-9) | Sixth | 19½ out |
| Sunday, July 11 |
| » Lost to Cubs (36-52), 9-2 | Wrigley Field (1-4) | 32-53 | Lost 4 |
| » W: Doug Bird (6-8) L: Tom Seaver (4-10) | Sixth | 19 out |
| » Defeated Cubs (36-53), 6-5 | Wrigley Field (2-4) | 33-53 | |
| » W: Mario Soto (8-5) L: Mike Proly (1-1) | Sixth | 19 out |
| Thursday, July 15 |
| » Defeated Cardinals (48-40), 7-3 | Busch Stadium II (2-1) | 34-53 | Won 2 |
| » W: Bruce Berenyi (6-9) L: John Stuper (4-2) S: Jim Kern (2) | Sixth | 19 out |
| » Major-league debuts: Tom Lawless (Reds) |
| Future Red Ryan Wagner is born in Yoakum, TX. |
| Friday, July 16 |
| » Lost to Cardinals (49-40), 6-4 | Busch Stadium II (2-2) | 34-54 | |
| » W: Jeff Lahti (1-0) L: Tom Hume (2-5) S: Bruce Sutter (19) | Sixth | 19 out |
| Saturday, July 17 |
| » Lost to Cardinals (50-40), 4-2 | Busch Stadium II (2-3) | 34-55 | Lost 2 |
| » W: Bob Forsch (9-5) L: Mario Soto (8-6) S: Doug Bair (5) | Sixth | 20 out |
| Sunday, July 18 |
| » Lost to Cardinals (51-40), 6-5 | Busch Stadium II (2-4) | 34-56 | Lost 3 |
| » W: Jim Kaat (4-1) L: Charlie Leibrandt (3-5) S: Bruce Sutter (20) | Sixth | 21 out |
| Monday, July 19 |
| » Lost to Pirates (46-43), 5-4 | Riverfront Stadium (17-25) | 34-57 | Lost 4 |
| » W: Manny Sarmiento (4-1) L: Frank Pastore (4-7) S: Kent Tekulve (13) | Sixth | 22 out |
| Tuesday, July 20 |
| » Lost to Pirates (47-43), 3-1 | Riverfront Stadium (17-26) | 34-58 | Lost 5 |
| » W: John Candelaria (6-4) L: Bruce Berenyi (6-10) S: Kent Tekulve (14) | Sixth | 23 out |
| Wednesday, July 21 |
| » Lost to Pirates (48-43), 3-2 | Riverfront Stadium (17-27) | 34-59 | Lost 6 |
| » Manager: Russ Nixon |
| » W: Larry McWilliams (6-4) L: Tom Hume (2-6) S: Kent Tekulve (15) | Sixth | 23 out |
| Thursday, July 22 |
| Former Red Lloyd Waner dies in Oklahoma City, OK at the age of 77. |
| Friday, July 23 |
| » Lost to Cubs (40-57), 7-5 | Riverfront Stadium (17-28) | 34-60 | Lost 7 |
| » W: Willie Hernandez (4-5) L: Jim Kern (1-4) S: Lee Smith (3) | Sixth | 23 out |
| Saturday, July 24 |
| » Defeated Cubs (40-58), 5-2 | Riverfront Stadium (18-28) | 35-60 | |
| » W: Frank Pastore (5-7) L: Doug Bird (6-10) S: Joe Price (1) | Sixth | 23 out |
| Sunday, July 25 |
| » Defeated Cubs (40-59), 2-1 | Riverfront Stadium (19-28) | 36-60 | Won 2 |
| » W: Bruce Berenyi (7-10) L: Fergie Jenkins (6-11) | Sixth | 22 out |
| Monday, July 26 |
| » Defeated Cubs (40-60), 4-2 | Riverfront Stadium (20-28) | 37-60 | Won 3 |
| » W: Bob Shirley (3-7) L: Allen Ripley (3-3) S: Tom Hume (17) | Sixth | 21½ out |
| Tuesday, July 27 |
| » Lost to Astros (42-54), 3-2 | Astrodome (2-2) | 37-61 | |
| » W: Nolan Ryan (11-9) L: Charlie Leibrandt (3-6) | Sixth | 23 out |
| Wednesday, July 28 |
| » Lost to Astros (43-54), 4-2 | Astrodome (2-3) | 37-62 | Lost 2 |
| » W: Joe Niekro (10-7) L: Mario Soto (8-7) | Sixth | 24 out |
| Thursday, July 29 |
| » Lost to Astros (44-54), 4-3 | Astrodome (2-4) | 37-63 | Lost 3 |
| » W: Randy Moffitt (1-3) L: Greg Harris (2-3) S: Frank LaCorte (3) | Sixth | 25 out |
| Friday, July 30 |
| » Defeated Padres (53-48), 4-2 | Riverfront Stadium (21-28) | 38-63 | |
| » W: Bruce Berenyi (8-10) L: John Montefusco (8-6) | Sixth | 23½ out |
| Saturday, July 31 |
| » Lost to Padres (54-48), 5-4 | Riverfront Stadium (21-29) | 38-64 | |
| » W: Tim Lollar (11-5) L: Tom Seaver (4-11) S: Dave Dravecky (1) | Sixth | 24 out |
| » Lost to Padres (55-48), 6-2 | Riverfront Stadium (21-30) | 38-65 | Lost 2 |
| » W: Eric Show (8-3) L: Bob Shirley (3-8) S: Gary Lucas (13) | Sixth | 24 out |
| » Major-league debuts: Jody Lansford (Padres) |
| Sunday, August 1 |
| » Lost to Padres (56-48), 8-6 | Riverfront Stadium (21-31) | 38-66 | Lost 3 |
| » W: John Curtis (7-6) L: Charlie Leibrandt (3-7) S: Luis DeLeon (10) | Sixth | 24 out |
| Monday, August 2 |
| » Defeated Dodgers (56-50), 5-1 | Riverfront Stadium (22-31) | 39-66 | |
| » W: Mario Soto (9-7) L: Jerry Reuss (10-9) | Sixth | 24 out |
| Tuesday, August 3 |
| » Lost to Dodgers (57-50), 4-0 | Riverfront Stadium (22-32) | 39-67 | |
| » W: Bob Welch (12-7) L: Frank Pastore (5-8) | Sixth | 24 out |
| Wednesday, August 4 |
| » Lost to Dodgers (58-50), 8-2 | Riverfront Stadium (22-33) | 39-68 | Lost 2 |
| » W: Ricky Wright (1-0) L: Bruce Berenyi (8-11) | Sixth | 24 out |
| Thursday, August 5 |
| » Defeated Padres (57-51), 4-2 | San Diego/Jack Murphy Stadium (2-2) | 40-68 | |
| » W: Tom Seaver (5-11) L: Tim Lollar (11-6) S: Brad Lesley (1) | Sixth | 23 out |
| Friday, August 6 |
| » Lost to Padres (58-51), 2-0 | San Diego/Jack Murphy Stadium (2-3) | 40-69 | |
| » W: Eric Show (9-3) L: Bob Shirley (3-9) | Sixth | 23 out |
| Saturday, August 7 |
| » Lost to Padres (59-51), 4-1 | San Diego/Jack Murphy Stadium (2-4) | 40-70 | Lost 2 |
| » W: Andy Hawkins (2-2) L: Mario Soto (9-8) S: Gary Lucas (14) | Sixth | 23 out |
| Sunday, August 8 |
| » Lost to Padres (60-51), 3-1 | San Diego/Jack Murphy Stadium (2-5) | 40-71 | Lost 3 |
| » W: Dave Dravecky (2-1) L: Frank Pastore (5-9) S: Gary Lucas (15) | Sixth | 23 out |
| Monday, August 9 |
| » Lost to Dodgers (63-50), 3-2 | Dodger Stadium (2-3) | 40-72 | Lost 4 |
| » W: Dave Stewart (7-6) L: Jim Kern (1-5) | Sixth | 23 out |
| Tuesday, August 10 |
| » Lost to Dodgers (64-50), 11-3 | Dodger Stadium (2-4) | 40-73 | Lost 5 |
| » W: Fernando Valenzuela (15-8) L: Tom Seaver (5-12) | Sixth | 23½ out |
| Wednesday, August 11 |
| » Defeated Dodgers (64-51), 2-1 | Dodger Stadium (3-4) | 41-73 | |
| » W: Bob Shirley (4-9) L: Burt Hooton (1-5) S: Brad Lesley (2) | Sixth | 22½ out |
| Friday, August 13 |
| » Defeated Astros (51-63), 3-0 | Riverfront Stadium (23-33) | 42-73 | Won 2 |
| » W: Frank Pastore (6-9) L: Joe Niekro (11-9) | Sixth | 23 out |
| Saturday, August 14 |
| » Lost to Astros (52-63), 2-0 | Riverfront Stadium (23-34) | 42-74 | |
| » W: Bob Knepper (5-12) L: Bruce Berenyi (8-12) S: Randy Moffitt (3) | Sixth | 23 out |
| Sunday, August 15 |
| » Lost to Astros (53-63), 7-3 | Riverfront Stadium (23-35) | 42-75 | Lost 2 |
| » W: Don Sutton (12-8) L: Tom Seaver (5-13) S: Bert Roberge (2) | Sixth | 23 out |
| Monday, August 16 |
| » Defeated Astros (53-64), 3-2 | Riverfront Stadium (24-35) | 43-75 | |
| » W: Jim Kern (2-5) L: Dave Smith (1-4) | Sixth | 22½ out |
| Tuesday, August 17 |
| » Defeated Mets (50-67), 9-2 | Riverfront Stadium (25-35) | 44-75 | Won 2 |
| » W: Mario Soto (10-8) L: Rick Ownbey (0-1) | Sixth | 22 out |
| » Major-league debuts: Rick Ownbey (Mets) |
| Wednesday, August 18 |
| » Defeated Mets (50-68), 7-6 | Riverfront Stadium (26-35) | 45-75 | Won 3 |
| » W: Ben Hayes (1-0) L: Mike Scott (7-10) | Sixth | 22½ out |
| Thursday, August 19 |
| » Defeated Mets (50-69), 3-1 | Riverfront Stadium (27-35) | 46-75 | Won 4 |
| » W: Jim Kern (3-5) L: Tom Hausman (1-1) | Sixth | 21½ out |
| Friday, August 20 |
| » Lost to Phillies (68-53), 9-2 | Riverfront Stadium (27-36) | 46-76 | |
| » W: Dick Ruthven (9-10) L: Greg Harris (2-4) | Sixth | 22½ out |
| Saturday, August 21 |
| » Defeated Phillies (68-54), 10-3 | Riverfront Stadium (28-36) | 47-76 | |
| » W: Bob Shirley (5-9) L: Marty Bystrom (5-5) | Sixth | 21½ out |
| Sunday, August 22 |
| » Lost to Phillies (69-54), 8-2 | Riverfront Stadium (28-37) | 47-77 | |
| » W: Larry Christenson (8-8) L: Mario Soto (10-9) | Sixth | 21½ out |
| Monday, August 23 |
| » Defeated Expos (65-59), 6-2 | Riverfront Stadium (29-37) | 48-77 | |
| » W: Frank Pastore (7-9) L: Bill Gullickson (10-10) | Sixth | 20½ out |
| Tuesday, August 24 |
| » Lost to Expos (66-59), 5-1 | Riverfront Stadium (29-38) | 48-78 | |
| » W: Scott Sanderson (7-11) L: Bruce Berenyi (8-13) | Sixth | 21½ out |
| Wednesday, August 25 |
| » Defeated Expos (66-60), 1-0 | Riverfront Stadium (30-38) | 49-78 | |
| » W: Bob Shirley (6-9) L: Steve Rogers (14-7) S: Brad Lesley (3) | Sixth | 21½ out |
| Friday, August 27 |
| » Defeated Phillies (70-57), 8-1 | Veteran's Stadium (2-2) | 50-78 | Won 2 |
| » W: Mario Soto (11-9) L: Larry Christenson (8-9) | Sixth | 21½ out |
| Saturday, August 28 |
| » Lost to Phillies (71-57), 7-1 | Veteran's Stadium (2-3) | 50-79 | |
| » W: Mike Krukow (12-7) L: Frank Pastore (7-10) | Sixth | 22½ out |
| Sunday, August 29 |
| » Lost to Phillies (72-57), 3-1 | Veteran's Stadium (2-4) | 50-80 | Lost 2 |
| » W: Steve Carlton (17-9) L: Bruce Berenyi (8-14) | Sixth | 22½ out |
| Monday, August 30 |
| » Lost to Expos (70-61), 3-1 | Stade Olympique (1-3) | 50-81 | Lost 3 |
| » W: Steve Rogers (15-7) L: Bob Shirley (6-10) S: Jeff Reardon (20) | Sixth | 23 out |
| Tuesday, August 31 |
| » Defeated Expos (70-62), 2-1 | Stade Olympique (2-3) | 51-81 | |
| » W: Charlie Leibrandt (4-7) L: Ray Burris (4-14) | Sixth | 23 out |
| Wednesday, September 1 |
| » Lost to Expos (71-62), 2-1 | Stade Olympique (2-4) | 51-82 | |
| » W: Randy Lerch (9-7) L: Mario Soto (11-10) S: Jeff Reardon (21) | Sixth | 24 out |
| Friday, September 3 |
| » Defeated Mets (51-81), 1-0 | Shea Stadium (2-2) | 52-82 | |
| » W: Frank Pastore (8-10) L: Rick Ownbey (0-2) S: Brad Lesley (4) | Sixth | 24 out |
| Saturday, September 4 |
| » Lost to Mets (52-81), 3-2 | Shea Stadium (2-3) | 52-83 | |
| » W: Craig Swan (8-6) L: Bruce Berenyi (8-15) S: Charlie Puleo (1) | Sixth | 24 out |
| Sunday, September 5 |
| » Lost to Mets (53-81), 10-2 | Shea Stadium (2-4) | 52-84 | Lost 2 |
| » W: Ed Lynch (3-6) L: Bob Shirley (6-11) S: Jesse Orosco (2) | Sixth | 24 out |
| Monday, September 6 |
| » Lost to Dodgers (76-62), 7-2 | Riverfront Stadium (30-39) | 52-85 | Lost 3 |
| » W: Jerry Reuss (14-10) L: Mario Soto (11-11) | Sixth | 24 out |
| Tuesday, September 7 |
| » Lost to Dodgers (77-62), 8-4 | Riverfront Stadium (30-40) | 52-86 | Lost 4 |
| » W: Dave Stewart (8-7) L: Greg Harris (2-5) | Sixth | 24½ out |
| » Major-league debuts: Gary Redus and Bill Scherrer (Reds) |
| Wednesday, September 8 |
| » Lost to Padres (73-67), 9-4 | Riverfront Stadium (30-41) | 52-87 | Lost 5 |
| » W: Luis DeLeon (7-4) L: Brad Lesley (0-1) | Sixth | 25 out |
| Thursday, September 9 |
| » Lost to Padres (74-67), 4-1 | Riverfront Stadium (30-42) | 52-88 | Lost 6 |
| » W: Tim Lollar (14-8) L: Bruce Berenyi (8-16) S: Luis DeLeon (13) | Sixth | 26 out |
| Friday, September 10 |
| » Lost to Braves (79-62), 8-2 | Atlanta-Fulton County Stadium (1-6) | 52-89 | Lost 7 |
| » W: Pascual Perez (1-4) L: Bob Shirley (6-12) | Sixth | 27 out |
| Saturday, September 11 |
| » Defeated Braves (79-63), 4-3 | Atlanta-Fulton County Stadium (2-6) | 53-89 | |
| » W: Mario Soto (12-11) L: Tommy Boggs (2-1) | Sixth | 26 out |
| Sunday, September 12 |
| » Lost to Braves (80-63), 4-3 | Atlanta-Fulton County Stadium (2-7) | 53-90 | |
| » W: Steve Bedrosian (8-6) L: Greg Harris (2-6) | Sixth | 27 out |
| Monday, September 13 |
| » Defeated Giants (74-69), 5-4 | Candlestick Park (2-5) | 54-90 | |
| » W: Joe Price (3-3) L: Gary Lavelle (9-7) S: Charlie Leibrandt (2) | Sixth | 26½ out |
| Tuesday, September 14 |
| » Lost to Giants (75-69), 2-1 | Candlestick Park (2-6) | 54-91 | |
| » W: Atlee Hammaker (10-8) L: Bruce Berenyi (8-17) S: Al Holland (3) | Sixth | 27½ out |
| Wednesday, September 15 |
| » Lost to Giants (76-69), 5-4 | Candlestick Park (2-7) | 54-92 | Lost 2 |
| » W: Rich Gale (6-14) L: Joe Price (3-4) S: Gary Lavelle (6) | Sixth | 28½ out |
| Friday, September 17 |
| » Defeated Braves (80-67), 5-2 | Riverfront Stadium (31-42) | 55-92 | |
| » W: Mario Soto (13-11) L: Rick Camp (11-9) | Sixth | 28½ out |
| Saturday, September 18 |
| » Lost to Braves (81-67), 5-4 | Riverfront Stadium (31-43) | 55-93 | |
| » W: Phil Niekro (15-4) L: Frank Pastore (8-11) S: Gene Garber (28) | Sixth | 28½ out |
| Sunday, September 19 |
| » Lost to Braves (82-67), 6-1 | Riverfront Stadium (31-44) | 55-94 | Lost 2 |
| » W: Pascual Perez (2-4) L: Bruce Berenyi (8-18) | Sixth | 29½ out |
| Tuesday, September 21 |
| » Defeated Giants (79-71), 6-5 | Riverfront Stadium (32-44) | 56-94 | |
| » W: Bob Shirley (7-12) L: Fred Breinin |
