| Monday, April 5 |
| » Defeated Royals (0-1), 13-5 | Memorial Stadium (1-0) | 1-0 | |
| » W: Sammy Stewart (1-0) L: Dennis Leonard (0-1) | First | -- |
| Friday, April 9 |
| » Major-league debuts: Gary Rajsich (Mets) |
| Saturday, April 10 |
| » Lost to Red Sox (1-0), 2-0 | Memorial Stadium (1-1) | 1-1 | |
| » W: Dennis Eckersley (1-0) L: Scott McGregor (0-1) | First | -- |
| » Defeated Red Sox (1-1), 5-3 | Memorial Stadium (2-1) | 2-1 | |
| » W: Dennis Martinez (1-0) L: Bob Ojeda (0-1) S: Sammy Stewart (1) | First | -- |
| » Major-league debuts: Wade Boggs (Red Sox) |
| Sunday, April 11 |
| » Lost to Red Sox (2-1), 6-0 | Memorial Stadium (2-2) | 2-2 | |
| » W: John Tudor (1-0) L: Mike Flanagan (0-1) | Third | ½ out |
| Tuesday, April 13 |
| » Lost to Royals (3-2), 6-5 | Royals Stadium (0-1) | 2-3 | Lost 2 |
| » W: Dave Frost (1-0) L: Sammy Stewart (1-1) S: Dan Quisenberry (2) | Third | 1½ out |
| Wednesday, April 14 |
| » Lost to Royals (4-2), 4-3 | Royals Stadium (0-2) | 2-4 | Lost 3 |
| » W: Dave Frost (2-0) L: Don Stanhouse (0-1) | Fifth | 1½ out |
| Saturday, April 17 |
| » Lost to White Sox (6-0), 3-1 | Comiskey Park I (0-1) | 2-5 | Lost 4 |
| » W: Britt Burns (2-0) L: Dennis Martinez (1-1) S: Salome Barojas (4) | Fourth | 1½ out |
| » Lost to White Sox (7-0), 10-6 | Comiskey Park I (0-2) | 2-6 | Lost 5 |
| » W: La Marr Hoyt (1-0) L: Tippy Martinez (0-1) | Fourth | 1½ out |
| Sunday, April 18 |
| » Lost to White Sox (8-0), 6-4 | Comiskey Park I (0-3) | 2-7 | Lost 6 |
| » W: La Marr Hoyt (2-0) L: Scott McGregor (0-2) S: Salome Barojas (5) | Seventh | 2½ out |
| Tuesday, April 20 |
| » Lost to Red Sox (5-6), 8-3 | Fenway Park (0-1) | 2-8 | Lost 7 |
| » W: Bob Ojeda (1-2) L: Mike Flanagan (0-2) S: Luis Aponte (1) | Sixth | 4 out |
| Wednesday, April 21 |
| » Lost to Red Sox (6-6), 6-5 | Fenway Park (0-2) | 2-9 | Lost 8 |
| » W: Dennis Eckersley (2-1) L: Dennis Martinez (1-2) S: Mark Clear (2) | Sixth | 5 out |
| Friday, April 23 |
| » Lost to White Sox (9-2), 4-2 | Memorial Stadium (2-3) | 2-10 | Lost 9 |
| » W: La Marr Hoyt (3-0) L: Jim Palmer (0-1) S: Jerry Koosman (2) | Sixth | 6½ out |
| Saturday, April 24 |
| » Defeated White Sox (9-3), 7-4 | Memorial Stadium (3-3) | 3-10 | |
| » W: Sammy Stewart (2-1) L: Kevin Hickey (1-1) | Seventh | 6½ out |
| Sunday, April 25 |
| » Defeated White Sox (9-4), 2-1 | Memorial Stadium (4-3) | 4-10 | Won 2 |
| » W: Dennis Martinez (2-2) L: Steve Trout (1-2) S: Tippy Martinez (1) | Sixth | 5½ out |
| Wednesday, April 28 |
| » Lost to Athletics (9-10), 6-2 | Memorial Stadium (4-4) | 4-11 | |
| » W: Mike Norris (1-2) L: Mike Flanagan (0-3) | Fifth | 5½ out |
| » Defeated Athletics (9-11), 5-1 | Memorial Stadium (5-4) | 5-11 | |
| » W: Scott McGregor (1-2) L: Matt Keough (2-2) | Fifth | 5½ out |
| Thursday, April 29 |
| » Lost to Athletics (10-11), 9-6 | Memorial Stadium (5-5) | 5-12 | |
| » W: Dave Beard (2-0) L: Tippy Martinez (0-2) | Seventh | 6 out |
| » Major-league debuts: Storm Davis (Orioles) |
| Friday, April 30 |
| » Defeated Angels (15-7), 9-4 | Memorial Stadium (6-5) | 6-12 | |
| » W: Jim Palmer (1-1) L: Stan Bahnsen (0-1) | Seventh | 6 out |
| Saturday, May 1 |
| » Lost to Angels (16-7), 6-4 | Memorial Stadium (6-6) | 6-13 | |
| » W: Don Aase (2-1) L: Tippy Martinez (0-3) | Sixth | 7 out |
| Sunday, May 2 |
| » Defeated Angels (16-8), 6-4 | Memorial Stadium (7-6) | 7-13 | |
| » W: Scott McGregor (2-2) L: Angel Moreno (2-3) | Seventh | 7 out |
| Monday, May 3 |
| » Defeated Mariners (11-15), 6-0 | Memorial Stadium (8-6) | 8-13 | Won 2 |
| » W: Mike Flanagan (1-3) L: Mike Moore (1-4) | Sixth | 7 out |
| Tuesday, May 4 |
| » Lost to Mariners (12-15), 4-3 | Memorial Stadium (8-7) | 8-14 | |
| » W: Gene Nelson (1-4) L: Sammy Stewart (2-2) S: Ed Vande Berg (2) | Sixth | 8 out |
| Thursday, May 6 |
| » Defeated Angels (17-10), 9-2 | Anaheim Stadium (1-0) | 9-14 | |
| » W: Ross Grimsley (1-0) L: Don Aase (3-2) | Fourth | 7½ out |
| Friday, May 7 |
| » Defeated Angels (17-11), 5-3 | Anaheim Stadium (2-0) | 10-14 | Won 2 |
| » W: Scott McGregor (3-2) L: Angel Moreno (2-4) S: Tippy Martinez (2) | Fourth | 6½ out |
| Saturday, May 8 |
| » Lost to Angels (18-11), 7-2 | Anaheim Stadium (2-1) | 10-15 | |
| » W: Steve Renko (3-1) L: Mike Flanagan (1-4) S: Don Aase (3) | Sixth | 7½ out |
| Sunday, May 9 |
| » Lost to Angels (19-11), 8-4 | Anaheim Stadium (2-2) | 10-16 | Lost 2 |
| » W: Bruce Kison (1-0) L: Dennis Martinez (2-3) | Seventh | 8½ out |
| Monday, May 10 |
| » Lost to Athletics (17-14), 7-6 | Oakland-Alameda County Stadium (0-1) | 10-17 | Lost 3 |
| » W: Dave Beard (3-0) L: Ross Grimsley (1-1) | Seventh | 9½ out |
| Tuesday, May 11 |
| » Defeated Athletics (17-15), 7-1 | Oakland-Alameda County Stadium (1-1) | 11-17 | |
| » W: Scott McGregor (4-2) L: Rick Langford (2-5) | Seventh | 8½ out |
| Wednesday, May 12 |
| » Lost to Athletics (18-15), 5-4 | Oakland-Alameda County Stadium (1-2) | 11-18 | |
| » W: Dave Beard (4-0) L: Tim Stoddard (0-1) | Seventh | 9½ out |
| Thursday, May 13 |
| » Defeated Mariners (15-20), 3-1 | Kingdome (1-0) | 12-18 | |
| » W: Dennis Martinez (3-3) L: Jim Beattie (0-4) | Sixth | 8½ out |
| Friday, May 14 |
| » Defeated Mariners (15-21), 11-4 | Kingdome (2-0) | 13-18 | Won 2 |
| » W: Sammy Stewart (3-2) L: Gene Nelson (1-6) S: Jim Palmer (1) | Sixth | 8 out |
| Saturday, May 15 |
| » Lost to Mariners (16-21), 3-2 | Kingdome (2-1) | 13-19 | |
| » W: Bill Caudill (4-1) L: Scott McGregor (4-3) | Seventh | 9 out |
| Sunday, May 16 |
| » Defeated Mariners (16-22), 5-4 | Kingdome (3-1) | 14-19 | |
| » W: Tippy Martinez (1-3) L: Gaylord Perry (3-3) S: Tim Stoddard (1) | Fifth | 8 out |
| Tuesday, May 18 |
| » Lost to Twins (12-27), 8-7 | Memorial Stadium (8-8) | 14-20 | |
| » W: Bobby Castillo (2-1) L: Jim Palmer (1-2) S: Ron Davis (3) | Sixth | 8 out |
| Wednesday, May 19 |
| » Defeated Twins (12-28), 4-2 | Memorial Stadium (9-8) | 15-20 | |
| » W: Sammy Stewart (4-2) L: Pete Filson (0-1) S: Tim Stoddard (2) | Fifth | 8 out |
| Thursday, May 20 |
| » Defeated Twins (12-29), 6-0 | Memorial Stadium (10-8) | 16-20 | Won 2 |
| » W: Scott McGregor (5-3) L: Pete Redfern (2-5) | Fifth | 8 out |
| Friday, May 21 |
| » Defeated Blue Jays (16-22), 3-0 | Exhibition Stadium (1-0) | 17-20 | Won 3 |
| » W: Mike Flanagan (2-4) L: Jim Gott (0-1) S: Tippy Martinez (3) | Fifth | 8 out |
| Saturday, May 22 |
| » Defeated Blue Jays (16-23), 6-0 | Exhibition Stadium (2-0) | 18-20 | Won 4 |
| » W: Dennis Martinez (4-3) L: Dave Stieb (2-5) | Fifth | 8 out |
| Sunday, May 23 |
| » Lost to Blue Jays (17-23), 7-1 | Exhibition Stadium (2-1) | 18-21 | |
| » W: Luis Leal (3-2) L: Sammy Stewart (4-3) | Fourth | 9 out |
| Monday, May 24 |
| » Defeated Blue Jays (17-24), 7-5 | Exhibition Stadium (3-1) | 19-21 | |
| » W: Scott McGregor (6-3) L: Jim Clancy (5-3) S: Tim Stoddard (3) | Fourth | 8½ out |
| Tuesday, May 25 |
| » Defeated Rangers (11-26), 10-3 | Arlington Stadium (1-0) | 20-21 | Won 2 |
| » W: Jim Palmer (2-2) L: Doc Medich (2-5) | Fifth | 7½ out |
| Wednesday, May 26 |
| » Lost to Rangers (12-26), 5-3 | Arlington Stadium (1-1) | 20-22 | |
| » W: Jon Matlack (1-2) L: Dennis Martinez (4-4) S: Paul Mirabella (1) | Fifth | 8 out |
| Thursday, May 27 |
| » Defeated Rangers (12-27), 6-0 | Arlington Stadium (2-1) | 21-22 | |
| » W: Sammy Stewart (5-3) L: Frank Tanana (1-7) | Fifth | 7 out |
| Saturday, May 29 |
| » Defeated Blue Jays (18-26), 3-1 | Memorial Stadium (11-8) | 22-22 | Won 2 |
| » W: Mike Flanagan (3-4) L: Luis Leal (3-3) | Fourth | 7 out |
| » Lost to Blue Jays (19-26), 11-10 | Memorial Stadium (11-9) | 22-23 | |
| » W: Joey McLaughlin (2-2) L: Tim Stoddard (0-2) | Fourth | 7 out |
| Former Oriole Erv Palica dies in Huntington Beach, CA at the age of 55. |
| Sunday, May 30 |
| » Lost to Blue Jays (20-26), 6-0 | Memorial Stadium (11-10) | 22-24 | Lost 2 |
| » W: Jim Gott (1-2) L: Jim Palmer (2-3) S: Roy Lee Jackson (4) | Fifth | 7 out |
| Monday, May 31 |
| » Defeated Rangers (14-29), 8-7 | Memorial Stadium (12-10) | 23-24 | |
| » W: Dennis Martinez (5-4) L: Jon Matlack (1-3) S: Tippy Martinez (4) | Fifth | 7 out |
| Wednesday, June 2 |
| » Lost to Rangers (15-29), 4-1 | Memorial Stadium (12-11) | 23-25 | |
| » W: Frank Tanana (2-7) L: Sammy Stewart (5-4) | Sixth | 8 out |
| Friday, June 4 |
| » Lost to Twins (13-41), 6-0 | Hubert H. Humphrey Metrodome (0-1) | 23-26 | Lost 2 |
| » W: Brad Havens (2-4) L: Scott McGregor (6-4) S: Terry Felton (1) | Fifth | 8 out |
| Saturday, June 5 |
| » Defeated Twins (13-42), 3-1 | Hubert H. Humphrey Metrodome (1-1) | 24-26 | |
| » W: Mike Flanagan (4-4) L: Albert Williams (2-3) | Sixth | 7½ out |
| Sunday, June 6 |
| » Defeated Twins (13-43), 7-5 | Hubert H. Humphrey Metrodome (2-1) | 25-26 | Won 2 |
| » W: Tim Stoddard (1-2) L: Ron Davis (1-7) | Fifth | 7½ out |
| » Major-league debuts: Frank Viola (Twins) |
| Monday, June 7 |
| » Defeated Brewers (27-25), 7-2 | County Stadium (1-0) | 26-26 | Won 3 |
| » W: Jim Palmer (3-3) L: Mike Caldwell (3-5) | Fifth | 7 out |
| Tuesday, June 8 |
| » Defeated Brewers (27-26), 4-2 | County Stadium (2-0) | 27-26 | Won 4 |
| » W: Scott McGregor (7-4) L: Randy Lerch (3-5) | Third | 7 out |
| Wednesday, June 9 |
| » Defeated Brewers (27-27), 8-3 | County Stadium (3-0) | 28-26 | Won 5 |
| » W: Mike Flanagan (5-4) L: Moose Haas (3-3) | Third | 7 out |
| Thursday, June 10 |
| » Lost to Brewers (28-27), 9-7 | County Stadium (3-1) | 28-27 | |
| » W: Rollie Fingers (3-5) L: Tippy Martinez (1-4) | Third | 7½ out |
| Friday, June 11 |
| » Defeated Yankees (26-28), 9-4 | Memorial Stadium (13-11) | 29-27 | |
| » W: Dennis Martinez (6-4) L: Mike Morgan (3-3) S: Tippy Martinez (5) | Third | 7 out |
| Saturday, June 12 |
| » Defeated Yankees (26-29), 5-3 | Memorial Stadium (14-11) | 30-27 | Won 2 |
| » W: Tippy Martinez (2-4) L: Shane Rawley (4-3) S: Tim Stoddard (4) | Third | 7 out |
| Monday, June 14 |
| » Defeated Brewers (30-29), 9-4 | Memorial Stadium (15-11) | 31-27 | Won 3 |
| » W: Scott McGregor (8-4) L: Moose Haas (3-4) | Third | 6 out |
| Tuesday, June 15 |
| » Lost to Brewers (31-29), 6-3 | Memorial Stadium (15-12) | 31-28 | |
| » W: Bob McClure (4-2) L: Mike Flanagan (5-5) S: Jim Slaton (4) | Third | 6 out |
| Wednesday, June 16 |
| » Tied Brewers, 2-2 | Memorial Stadium (15-12) | 31-28 | |
| » Starters: Pete Vuckovich vs Dennis Martinez | Third | 5½ out |
| Friday, June 18 |
| » Defeated Yankees (29-30), 4-1 | Yankee Stadium (1-0) | 32-28 | |
| » W: Jim Palmer (4-3) L: Mike Morgan (3-4) S: Tippy Martinez (6) | Third | 5 out |
| Saturday, June 19 |
| » Lost to Yankees (30-30), 4-3 | Yankee Stadium (1-1) | 32-29 | |
| » W: Dave LaRoche (1-1) L: Storm Davis (0-1) | Fourth | 6 out |
| Sunday, June 20 |
| » Defeated Yankees (30-31), 5-3 | Yankee Stadium (2-1) | 33-29 | |
| » W: Tippy Martinez (3-4) L: Rich Gossage (3-3) | Fourth | 5 out |
| Monday, June 21 |
| » Defeated Indians (31-32), 7-0 | Cleveland Stadium (1-0) | 34-29 | Won 2 |
| » W: Dennis Martinez (7-4) L: Rick Waits (0-5) | Fourth | 5 out |
| Tuesday, June 22 |
| » Lost to Indians (32-32), 8-6 | Cleveland Stadium (1-1) | 34-30 | |
| » W: Lary Sorensen (6-6) L: Sammy Stewart (5-5) | Fourth | 6 out |
| Wednesday, June 23 |
| » Defeated Indians (32-33), 3-1 | Cleveland Stadium (2-1) | 35-30 | |
| » W: Jim Palmer (5-3) L: John Denny (4-8) S: Tim Stoddard (5) | Fourth | 6 out |
| Thursday, June 24 |
| » Lost to Tigers (36-29), 7-1 | Memorial Stadium (15-13) | 35-31 | |
| » W: Jerry Ujdur (1-2) L: Scott McGregor (8-5) | Fourth | 6½ out |
| Friday, June 25 |
| » Defeated Tigers (36-30), 5-2 | Memorial Stadium (16-13) | 36-31 | |
| » W: Mike Flanagan (6-5) L: Dan Petry (6-5) S: Tim Stoddard (6) | Fourth | 5½ out |
| Saturday, June 26 |
| » Defeated Tigers (36-31), 4-1 | Memorial Stadium (17-13) | 37-31 | Won 2 |
| » W: Dennis Martinez (8-4) L: Milt Wilcox (5-4) | Third | 4½ out |
| Sunday, June 27 |
| » Defeated Tigers (36-32), 13-1 | Memorial Stadium (18-13) | 38-31 | Won 3 |
| » W: Jim Palmer (6-3) L: Jack Morris (8-9) | Third | 3½ out |
| Tuesday, June 29 |
| » Lost to Indians (35-35), 9-2 | Memorial Stadium (18-14) | 38-32 | |
| » W: John Denny (5-8) L: Scott McGregor (8-6) | Third | 5 out |
| Wednesday, June 30 |
| » Lost to Indians (36-35), 9-0 | Memorial Stadium (18-15) | 38-33 | Lost 2 |
| » W: Rick Sutcliffe (6-3) L: Mike Flanagan (6-6) | Third | 5 out |
| Thursday, July 1 |
| » Lost to Indians (37-35), 6-2 | Memorial Stadium (18-16) | 38-34 | Lost 3 |
| » W: Len Barker (9-4) L: Dennis Martinez (8-5) S: Dan Spillner (9) | Fourth | 5 out |
| Friday, July 2 |
| » Defeated Tigers (38-34), 5-4 | Tiger Stadium (1-0) | 39-34 | |
| » W: Jim Palmer (7-3) L: Pat Underwood (3-5) S: Tim Stoddard (7) | Third | 4 out |
| Saturday, July 3 |
| » Defeated Tigers (38-35), 8-3 | Tiger Stadium (2-0) | 40-34 | Won 2 |
| » W: Storm Davis (1-1) L: Jerry Ujdur (1-4) | Second | 3 out |
| Sunday, July 4 |
| » Lost to Tigers (39-35), 6-1 | Tiger Stadium (2-1) | 40-35 | |
| » W: Dan Petry (8-5) L: Mike Flanagan (6-7) | Third | 4 out |
| Monday, July 5 |
| » Defeated Angels (45-35), 8-5 | Anaheim Stadium (3-2) | 41-35 | |
| » W: Scott McGregor (9-6) L: Ken Forsch (7-7) S: Tippy Martinez (7) | Third | 3½ out |
| Tuesday, July 6 |
| » Defeated Angels (45-36), 3-2 | Anaheim Stadium (4-2) | 42-35 | Won 2 |
| » W: Dennis Martinez (9-5) L: Doug Corbett (1-7) S: Tippy Martinez (8) | Third | 2½ out |
| Wednesday, July 7 |
| » Lost to Mariners (44-38), 8-7 | Kingdome (3-2) | 42-36 | |
| » W: Bill Caudill (8-3) L: Tim Stoddard (1-3) | Third | 3½ out |
| Thursday, July 8 |
| » Lost to Mariners (45-38), 4-3 | Kingdome (3-3) | 42-37 | Lost 2 |
| » W: Mike Moore (4-6) L: Mike Flanagan (6-8) S: Bill Caudill (17) | Third | 4½ out |
| Friday, July 9 |
| » Defeated Athletics (37-49), 7-5 | Oakland-Alameda County Stadium (2-2) | 43-37 | |
| » W: Scott McGregor (10-6) L: Matt Keough (7-12) S: Tim Stoddard (8) | Third | 3½ out |
| Saturday, July 10 |
| » Lost to Athletics (38-49), 3-1 | Oakland-Alameda County Stadium (2-3) | 43-38 | |
| » W: Tom Underwood (5-4) L: Dennis Martinez (9-6) S: Dave Beard (8) | Third | 4½ out |
| Sunday, July 11 |
| » Defeated Athletics (38-50), 8-7 | Oakland-Alameda County Stadium (3-3) | 44-38 | |
| » W: Storm Davis (2-1) L: Brian Kingman (1-6) S: Tim Stoddard (9) | Third | 3½ out |
| Thursday, July 15 |
| » Defeated Mariners (45-42), 3-2 | Memorial Stadium (19-16) | 45-38 | Won 2 |
| » W: Scott McGregor (11-6) L: Jim Beattie (6-6) S: Sammy Stewart (2) | Third | 4 out |
| Friday, July 16 |
| » Lost to Mariners (46-42), 6-0 | Memorial Stadium (19-17) | 45-39 | |
| » W: Floyd Bannister (9-5) L: Dennis Martinez (9-7) | Third | 5 out |
| Saturday, July 17 |
| » Defeated Mariners (46-43), 8-4 | Memorial Stadium (20-17) | 46-39 | |
| » W: Storm Davis (3-1) L: Gaylord Perry (6-8) | Third | 5 out |
| Sunday, July 18 |
| » Defeated Mariners (46-44), 4-3 | Memorial Stadium (21-17) | 47-39 | Won 2 |
| » W: Sammy Stewart (6-5) L: Mike Moore (4-7) | Third | 5 out |
| Monday, July 19 |
| » Lost to Angels (52-39), 6-5 | Memorial Stadium (21-18) | 47-40 | |
| » W: Steve Renko (8-2) L: Scott McGregor (11-7) S: Bruce Kison (1) | Third | 5 out |
| Tuesday, July 20 |
| » Lost to Angels (53-39), 7-4 | Memorial Stadium (21-19) | 47-41 | Lost 2 |
| » W: Dave Goltz (4-3) L: Dennis Martinez (9-8) S: Andy Hassler (2) | Second | 5 out |
| Wednesday, July 21 |
| » Defeated Angels (53-40), 8-7 | Memorial Stadium (22-19) | 48-41 | |
| » W: Sammy Stewart (7-5) L: Andy Hassler (2-1) S: Tippy Martinez (9) | Third | 5 out |
| Friday, July 23 |
| » Defeated Athletics (40-56), 2-1 | Memorial Stadium (23-19) | 49-41 | Won 2 |
| » W: Jim Palmer (8-3) L: Matt Keough (7-14) S: Tippy Martinez (10) | Third | 4 out |
| Saturday, July 24 |
| » Defeated Athletics (40-57), 5-4 | Memorial Stadium (24-19) | 50-41 | Won 3 |
| » W: Tippy Martinez (4-4) L: Bob Owchinko (1-2) | Third | 4 out |
| Sunday, July 25 |
| » Defeated Athletics (40-58), 6-2 | Memorial Stadium (25-19) | 51-41 | Won 4 |
| » W: Dennis Martinez (10-8) L: Brian Kingman (1-8) | Third | 3 out |
| Monday, July 26 |
| » Defeated White Sox (49-46), 6-2 | Memorial Stadium (26-19) | 52-41 | Won 5 |
| » W: Mike Flanagan (7-8) L: Jerry Koosman (2-5) S: Tim Stoddard (10) | Third | 2½ out |
| Tuesday, July 27 |
| » Defeated White Sox (49-47), 5-3 | Memorial Stadium (27-19) | 53-41 | Won 6 |
| » W: Tippy Martinez (5-4) L: Kevin Hickey (2-2) | Third | 2 out |
| Wednesday, July 28 |
| » Defeated White Sox (49-48), 2-1 | Memorial Stadium (28-19) | 54-41 | Won 7 |
| » W: Scott McGregor (12-7) L: Richard Dotson (3-11) S: Tippy Martinez (11) | Third | 2 out |
| Thursday, July 29 |
| » Lost to Royals (54-44), 7-2 | Royals Stadium (0-3) | 54-42 | |
| » W: Derek Botelho (2-1) L: Dennis Martinez (10-9) | Third | 2½ out |
| Friday, July 30 |
| » Lost to Royals (55-44), 4-3 | Royals Stadium (0-4) | 54-43 | Lost 2 |
| » W: Larry Gura (12-7) L: Sammy Stewart (7-6) S: Dan Quisenberry (24) | Third | 2½ out |
| Saturday, July 31 |
| » Lost to Royals (56-44), 2-0 | Royals Stadium (0-5) | 54-44 | Lost 3 |
| » W: Vida Blue (9-7) L: Mike Flanagan (7-9) | Third | 3 out |
| Sunday, August 1 |
| » Lost to Royals (57-44), 4-2 | Royals Stadium (0-6) | 54-45 | Lost 4 |
| » W: Bill Castro (1-1) L: Tippy Martinez (5-5) S: Dan Quisenberry (25) | Third | 3½ out |
| Monday, August 2 |
| » Lost to Red Sox (59-44), 5-2 | Memorial Stadium (28-20) | 54-46 | Lost 5 |
| » W: John Tudor (7-8) L: Scott McGregor (12-8) S: Bob Stanley (9) | Second | 3½ out |
| Tuesday, August 3 |
| » Defeated Red Sox (59-45), 7-2 | Memorial Stadium (29-20) | 55-46 | |
| » W: Dennis Martinez (11-9) L: Chuck Rainey (6-4) | Third | 4 out |
| » Lost to Red Sox (60-45), 7-6 | Memorial Stadium (29-21) | 55-47 | |
| » W: Mark Clear (9-4) L: Ross Grimsley (1-2) | Third | 4 out |
| Wednesday, August 4 |
| » Defeated Red Sox (60-46), 4-2 | Memorial Stadium (30-21) | 56-47 | |
| » W: Mike Flanagan (8-9) L: Bob Stanley (7-4) S: Tim Stoddard (11) | Third | 4 out |
| Thursday, August 5 |
| » Defeated Royals (59-46), 5-1 | Memorial Stadium (31-21) | 57-47 | Won 2 |
| » W: Jim Palmer (9-3) L: Vida Blue (9-8) | Third | 3½ out |
| Friday, August 6 |
| » Lost to Royals (60-46), 3-1 | Memorial Stadium (31-22) | 57-48 | |
| » W: Dave Frost (6-4) L: Storm Davis (3-2) S: Mike Armstrong (4) | Third | 5 out |
| » Lost to Royals (61-46), 4-0 | Memorial Stadium (31-23) | 57-49 | Lost 2 |
| » W: Don Hood (3-0) L: Scott McGregor (12-9) S: Dan Quisenberry (26) | Third | 5 out |
| Saturday, August 7 |
| » Defeated Royals (61-47), 6-5 | Memorial Stadium (32-23) | 58-49 | |
| » W: Tippy Martinez (6-5) L: Dan Quisenberry (6-5) | Third | 4 out |
| Sunday, August 8 |
| » Defeated Royals (61-48), 10-6 | Memorial Stadium (33-23) | 59-49 | Won 2 |
| » W: Tim Stoddard (2-3) L: Mike Armstrong (3-4) | Third | 4 out |
| Monday, August 9 |
| » Lost to White Sox (58-51), 9-5 | Comiskey Park I (0-4) | 59-50 | |
| » W: Kevin Hickey (3-2) L: Tippy Martinez (6-6) | Third | 5 out |
| Tuesday, August 10 |
| » Lost to White Sox (59-51), 9-4 | Comiskey Park I (0-5) | 59-51 | Lost 2 |
| » W: Britt Burns (13-4) L: Scott McGregor (12-10) | Third | 6 out |
| Wednesday, August 11 |
| » Lost to White Sox (60-51), 4-1 | Comiskey Park I (0-6) | 59-52 | Lost 3 |
| » W: Richard Dotson (6-11) L: Dennis Martinez (11-10) S: Dennis Lamp (5) | Third | 6 out |
| Friday, August 13 |
| » Lost to Red Sox (62-51), 5-2 | Fenway Park (0-3) | 59-53 | Lost 4 |
| » W: John Tudor (8-9) L: Mike Flanagan (8-10) | Third | 8 out |
| Saturday, August 14 |
| » Defeated Red Sox (62-52), 5-2 | Fenway Park (1-3) | 60-53 | |
| » W: Tippy Martinez (7-6) L: Mark Clear (9-5) | Third | 7 out |
| Sunday, August 15 |
| » Lost to Red Sox (63-52), 8-0 | Fenway Park (1-4) | 60-54 | |
| » W: Bob Stanley (8-5) L: Scott McGregor (12-11) | Third | 7 out |
| Monday, August 16 |
| » Lost to Red Sox (64-52), 9-4 | Fenway Park (1-5) | 60-55 | Lost 2 |
| » W: Tom Burgmeier (6-0) L: Storm Davis (3-3) | Third | 7½ out |
| Tuesday, August 17 |
| » Defeated Twins (40-78), 8-4 | Hubert H. Humphrey Metrodome (3-1) | 61-55 | |
| » W: Mike Flanagan (9-10) L: Jack O'Connor (5-4) | Third | 6½ out |
| Wednesday, August 18 |
| » Lost to Twins (41-78), 6-5 | Hubert H. Humphrey Metrodome (3-2) | 61-56 | |
| » W: Ron Davis (3-8) L: Tim Stoddard (2-4) | Third | 6½ out |
| Thursday, August 19 |
| » Lost to Twins (42-78), 9-3 | Hubert H. Humphrey Metrodome (3-3) | 61-57 | Lost 2 |
| » W: Bobby Castillo (7-9) L: Scott McGregor (12-12) | Third | 7½ out |
| Friday, August 20 |
| » Defeated Rangers (48-70), 4-2 | Arlington Stadium (3-1) | 62-57 | |
| » W: Tippy Martinez (8-6) L: Steve Comer (0-4) S: Sammy Stewart (3) | Third | 7½ out |
| Saturday, August 21 |
| » Defeated Rangers (48-71), 8-6 | Arlington Stadium (4-1) | 63-57 | Won 2 |
| » W: Tim Stoddard (3-4) L: Jon Matlack (5-6) | Third | 7½ out |
| Sunday, August 22 |
| » Defeated Rangers (48-72), 10-3 | Arlington Stadium (5-1) | 64-57 | Won 3 |
| » W: Jim Palmer (10-3) L: Rick Honeycutt (5-15) | Third | 7½ out |
| Tuesday, August 24 |
| » Defeated Blue Jays (59-67), 7-3 | Memorial Stadium (34-23) | 65-57 | Won 4 |
| » W: Dennis Martinez (12-10) L: Joey McLaughlin (8-6) | Third | 7 out |
| Wednesday, August 25 |
| » Defeated Blue Jays (59-68), 8-3 | Memorial Stadium (35-23) | 66-57 | Won 5 |
| » W: Mike Flanagan (10-10) L: Jim Clancy (11-11) | Third | 6½ out |
| Thursday, August 26 |
| » Defeated Blue Jays (59-69), 12-5 | Memorial Stadium (36-23) | 67-57 | Won 6 |
| » W: Storm Davis (4-3) L: Jim Gott (4-10) | Third | 6½ out |
| Friday, August 27 |
| » Defeated Rangers (49-76), 3-1 | Memorial Stadium (37-23) | 68-57 | Won 7 |
| » W: Jim Palmer (11-3) L: Mike Smithson (0-1) S: Tim Stoddard (12) | Third | 7 out |
| » Lost to Rangers (50-76), 4-3 | Memorial Stadium (37-24) | 68-58 | |
| » W: Steve Comer (1-4) L: Sammy Stewart (7-7) | Third | 7 out |
| » Major-league debuts: Mike Smithson (Rangers) |
| Saturday, August 28 |
| » Defeated Rangers (50-77), 8-3 | Memorial Stadium (38-24) | 69-58 | |
| » W: Dennis Martinez (13-10) L: Dave Schmidt (4-5) | Third | 6 out |
| Sunday, August 29 |
| » Defeated Rangers (50-78), 3-2 | Memorial Stadium (39-24) | 70-58 | Won 2 |
| » W: Mike Flanagan (11-10) L: Frank Tanana (6-15) | Third | 6 out |
| Monday, August 30 |
| » Defeated Blue Jays (61-71), 6-3 | Exhibition Stadium (4-1) | 71-58 | Won 3 |
| » W: Storm Davis (5-3) L: Mark Eichhorn (0-1) S: Tippy Martinez (12) | Third | 5 out |
| » Major-league debuts: Mark Eichhorn (Blue Jays) |
| Tuesday, August 31 |
| » Defeated Blue Jays (61-72), 1-0 | Exhibition Stadium (5-1) | 72-58 | Won 4 |
| » W: Jim Palmer (12-3) L: Luis Leal (9-12) | Third | 5 out |
| Wednesday, September 1 |
| » Defeated Blue Jays (61-73), 5-2 | Exhibition Stadium (6-1) | 73-58 | Won 5 |
| » W: Dennis Martinez (14-10) L: Dave Stieb (13-13) | Third | 5 out |
| Friday, September 3 |
| » Defeated Twins (48-85), 4-2 | Memorial Stadium (40-24) | 74-58 | Won 6 |
| » W: Mike Flanagan (12-10) L: Jack O'Connor (6-6) | Third | 4 out |
| Saturday, September 4 |
| » Defeated Twins (48-86), 3-0 | Memorial Stadium (41-24) | 75-58 | Won 7 |
| » W: Jim Palmer (13-3) L: Bobby Castillo (8-11) | Second | 4 out |
| Sunday, September 5 |
| » Defeated Twins (48-87), 5-4 | Memorial Stadium (42-24) | 76-58 | Won 8 |
| » W: Storm Davis (6-3) L: Pete Redfern (5-11) | Second | 4 out |
| Monday, September 6 |
| » Defeated Yankees (69-66), 8-2 | Yankee Stadium (3-1) | 77-58 | Won 9 |
| » W: Scott McGregor (13-12) L: Dave Righetti (8-8) S: Sammy Stewart (4) | Second | 3 out |
| Tuesday, September 7 |
| » Defeated Yankees (69-67), 7-2 | Yankee Stadium (4-1) | 78-58 | Won 10 |
| » W: Mike Flanagan (13-10) L: Mike Morgan (6-9) | Second | 3 out |
| Wednesday, September 8 |
| » Lost to Yankees (70-67), 10-5 | Yankee Stadium (4-2) | 78-59 | |
| » W: Jay Howell (1-1) L: Jim Palmer (13-4) | Second | 4 out |
| » Major-league debuts: Don Mattingly (Yankees) |
| Thursday, September 9 |
| » Lost to Indians (67-70), 3-0 | Cleveland Stadium (2-2) | 78-60 | Lost 2 |
| » W: Bud Anderson (3-1) L: Dennis Martinez (14-11) | Second | 4 out |
| Friday, September 10 |
| » Defeated Indians (67-71), 3-2 | Cleveland Stadium (3-2) | 79-60 | |
| » W: Sammy Stewart (8-7) L: Dan Spillner (12-9) | Second | 4 out |
| Saturday, September 11 |
| » Defeated Indians (67-72), 8-1 | Cleveland Stadium (4-2) | 80-60 | Won 2 |
| » W: Mike Flanagan (14-10) L: Lary Sorensen (10-13) | Second | 3 out |
| Sunday, September 12 |
| » Lost to Indians (68-72), 3-0 | Cleveland Stadium (4-3) | 80-61 | |
| » W: Rick Sutcliffe (12-6) L: Tippy Martinez (8-7) | Second | 3 out |
| Monday, September 13 |
| » Defeated Yankees (73-69), 8-7 | Memorial Stadium (43-24) | 81-61 | |
| » W: Mike Boddicker (1-0) L: Rudy May (6-4) S: Tippy Martinez (13) | Second | 2 out |
| Tuesday, September 14 |
| » Defeated Yankees (73-70), 5-4 | Memorial Stadium (44-24) | 82-61 | Won 2 |
| » W: John Flinn (1-0) L: Shane Rawley (10-9) S: Tippy Martinez (14) | Second | 1½ out |
| » Defeated Yankees (73-71), 5-3 | Memorial Stadium (45-24) | 83-61 | Won 3 |
| » W: Storm Davis (7-3) L: Mike Morgan (6-10) S: Tippy Martinez (15) | Second | 1½ out |
| » Major-league debuts: Mike Young (Orioles) |
| Wednesday, September 15 |
| » Defeated Yankees (73-72), 8-5 | Memorial Stadium (46-24) | 84-61 | Won 4 |
| » W: Don Welchel (1-0) L: Ron Guidry (14-7) S: Sammy Stewart (5) | Second | 1½ out |
| Thursday, September 16 |
| » Defeated Yankees (73-73), 3-1 | Memorial Stadium (47-24) | 85-61 | Won 5 |
| » W: Jim Palmer (14-4) L: Dave Righetti (9-9) | Second | 1 out |
| Friday, September 17 |
| » Lost to Indians (72-73), 5-3 | Memorial Stadium (47-25) | 85-62 | |
| » W: Rick Sutcliffe (13-6) L: Dennis Martinez (14-12) S: Ed Glynn (2) | Second | 2 out |
| Saturday, September 18 |
| » Defeated Indians (72-74), 5-2 | Memorial Stadium (48-25) | 86-62 | |
| » W: Scott McGregor (14-12) L: Bud Anderson (3-2) | Second | 2 out |
| Sunday, September 19 |
| » Defeated Indians (72-75), 4-2 | Memorial Stadium (49-25) | 87-62 | Won 2 |
| » W: Mike Flanagan (15-10) L: Ed Glynn (5-2) | Second | 2 out |
| Monday, September 20 |
| » Defeated Tigers (74-74), 3-1 | Memorial Stadium (50-25) | 88-62 | Won 3 |
| » W: Sammy Stewart (9-7) L: Jack Morris (16-16) | Second | 2 out |
| Tuesday, September 21 |
| » Lost to Tigers (75-74), 11-1 | Memorial Stadium (50-26) | 88-63 | |
| » W: Milt Wilcox (12-8) L: Storm Davis (7-4) | Second | 2 out |
| Thursday, September 23 |
| » Lost to Tigers (76-74), 10-5 | Memorial Stadium (50-27) | 88-64 | Lost 2 |
| » W: Dave Rucker (3-6) L: Sammy Stewart (9-8) | Second | 3 out |
| Friday, September 24 |
| » Lost to Brewers (92-61), 15-6 | County Stadium (3-2) | 88-65 | Lost 3 |
| » W: Don Sutton (16-9) L: Mike Flanagan (15-11) | Second | 4 out |
| Saturday, September 25 |
| » Defeated Brewers (92-62), 7-2 | County Stadium (4-2) | 89-65 | |
|