| Tuesday, April 6 |
| » Defeated Twins (0-1), 11-7 | Hubert H. Humphrey Metrodome (1-0) | 1-0 | |
| » W: Floyd Bannister (1-0) L: Pete Redfern (0-1) S: Mike Stanton (1) | First | -- |
| » Major-league debuts: Jim Eisenreich (Twins) |
| Wednesday, April 7 |
| » Lost to Twins (1-1), 7-5 | Hubert H. Humphrey Metrodome (1-1) | 1-1 | |
| » W: Roger Erickson (1-0) L: Jim Beattie (0-1) S: Doug Corbett (1) | Second | 1 out |
| » Major-league debuts: Edwin Nunez and Ed Vande Berg (Mariners) |
| Thursday, April 8 |
| » Lost to Twins (2-1), 4-1 | Hubert H. Humphrey Metrodome (1-2) | 1-2 | Lost 2 |
| » W: Brad Havens (1-0) L: Gene Nelson (0-1) S: Doug Corbett (2) | Third | 1 out |
| Friday, April 9 |
| » Lost to Athletics (2-2), 5-3 | Oakland-Alameda County Stadium (0-1) | 1-3 | Lost 3 |
| » W: Steve McCatty (1-0) L: Gaylord Perry (0-1) S: Bob Owchinko (1) | Fifth | 2 out |
| Sunday, April 11 |
| » Defeated Athletics (2-3), 6-3 | Oakland-Alameda County Stadium (1-1) | 2-3 | |
| » W: Bill Caudill (1-0) L: Bo McLaughlin (0-1) | Sixth | 2 out |
| » Lost to Athletics (3-3), 3-1 | Oakland-Alameda County Stadium (1-2) | 2-4 | |
| » W: Rick Langford (1-0) L: Mike Moore (0-1) | Sixth | 2 out |
| » Major-league debuts: Mike Moore (Mariners) |
| Tuesday, April 13 |
| » Game at Anaheim Stadium interrupted in the 18th inning with the score of Mariners 3, Angels 3. Completed on April 14. |
| Wednesday, April 14 |
| » Lost to Angels (4-3), 4-3 | Anaheim Stadium (0-1) | 2-5 | Lost 2 |
| » W: Luis Sanchez (2-0) L: Gene Nelson (0-2) | Sixth | 4 out |
| » Lost to Angels (5-3), 2-1 | Anaheim Stadium (0-2) | 2-6 | Lost 3 |
| » W: Steve Renko (2-0) L: Ed Vande Berg (0-1) | Sixth | 4 out |
| Thursday, April 15 |
| » Lost to Angels (6-3), 3-2 | Anaheim Stadium (0-3) | 2-7 | Lost 4 |
| » W: Angel Moreno (1-1) L: Gaylord Perry (0-2) | Sixth | 5 out |
| Friday, April 16 |
| » Defeated Athletics (5-5), 5-0 | Kingdome (1-0) | 3-7 | |
| » W: Floyd Bannister (2-0) L: Mike Norris (0-2) | Sixth | 4½ out |
| Saturday, April 17 |
| » Lost to Athletics (6-5), 10-3 | Kingdome (1-1) | 3-8 | |
| » W: Matt Keough (2-0) L: Mike Moore (0-2) | Seventh | 6 out |
| Sunday, April 18 |
| » Defeated Athletics (6-6), 4-3 | Kingdome (2-1) | 4-8 | |
| » W: Ed Vande Berg (1-1) L: Tom Underwood (0-1) | Seventh | 6 out |
| Monday, April 19 |
| » Lost to Angels (10-3), 3-1 | Kingdome (2-2) | 4-9 | |
| » W: Mike Witt (1-0) L: Gene Nelson (0-3) S: Don Aase (1) | Sixth | 6½ out |
| Tuesday, April 20 |
| » Defeated Angels (10-4), 6-4 | Kingdome (3-2) | 5-9 | |
| » W: Gaylord Perry (1-2) L: Angel Moreno (1-2) S: Mike Stanton (2) | Seventh | 5½ out |
| Wednesday, April 21 |
| » Defeated Angels (10-5), 5-3 | Kingdome (4-2) | 6-9 | Won 2 |
| » W: Floyd Bannister (3-0) L: Steve Renko (2-1) S: Bill Caudill (1) | Sixth | 4½ out |
| Thursday, April 22 |
| » Defeated Twins (6-10), 8-4 | Kingdome (5-2) | 7-9 | Won 3 |
| » W: Mike Moore (1-2) L: Pete Redfern (1-2) S: Mike Stanton (3) | Sixth | 4 out |
| Friday, April 23 |
| » Lost to Twins (7-10), 12-4 | Kingdome (5-3) | 7-10 | |
| » W: Roger Erickson (2-2) L: Edwin Nunez (0-1) | Sixth | 5 out |
| Saturday, April 24 |
| » Defeated Twins (7-11), 3-2 | Kingdome (6-3) | 8-10 | |
| » W: Ed Vande Berg (2-1) L: Ron Davis (1-1) S: Bill Caudill (2) | Sixth | 4 out |
| Sunday, April 25 |
| » Defeated Twins (7-12), 5-4 | Kingdome (7-3) | 9-10 | Won 2 |
| » W: Bill Caudill (2-0) L: Terry Felton (0-2) | Fourth | 4½ out |
| Tuesday, April 27 |
| » Defeated Indians (6-9), 7-4 | Cleveland Stadium (1-0) | 10-10 | Won 3 |
| » W: Bill Caudill (3-0) L: Dan Spillner (0-1) S: Ed Vande Berg (1) | Fourth | 4½ out |
| Wednesday, April 28 |
| » Lost to Indians (7-9), 6-1 | Cleveland Stadium (1-1) | 10-11 | |
| » W: Len Barker (3-1) L: Mike Moore (1-3) | Third | 4½ out |
| Thursday, April 29 |
| » Lost to Indians (8-9), 5-1 | Cleveland Stadium (1-2) | 10-12 | Lost 2 |
| » W: Lary Sorensen (1-1) L: Gene Nelson (0-4) | Fifth | 5½ out |
| Friday, April 30 |
| » Defeated Yankees (7-11), 6-3 | Yankee Stadium (1-0) | 11-12 | |
| » W: Gaylord Perry (2-2) L: Rich Gossage (0-2) S: Bill Caudill (3) | Fourth | 4½ out |
| Saturday, May 1 |
| » Lost to Yankees (8-11), 5-1 | Yankee Stadium (1-1) | 11-13 | |
| » W: George Frazier (1-0) L: Jim Beattie (0-2) | Fifth | 5½ out |
| Sunday, May 2 |
| » Lost to Yankees (9-11), 4-2 | Yankee Stadium (1-2) | 11-14 | Lost 2 |
| » W: Ron Guidry (3-1) L: Floyd Bannister (3-1) S: Rich Gossage (3) | Fourth | 5½ out |
| Monday, May 3 |
| » Lost to Orioles (8-13), 6-0 | Memorial Stadium (0-1) | 11-15 | Lost 3 |
| » W: Mike Flanagan (1-3) L: Mike Moore (1-4) | Fifth | 6½ out |
| Tuesday, May 4 |
| » Defeated Orioles (8-14), 4-3 | Memorial Stadium (1-1) | 12-15 | |
| » W: Gene Nelson (1-4) L: Sammy Stewart (2-2) S: Ed Vande Berg (2) | Fifth | 5½ out |
| Thursday, May 6 |
| » Defeated Yankees (9-14), 7-3 | Kingdome (8-3) | 13-15 | Won 2 |
| » W: Gaylord Perry (3-2) L: Doyle Alexander (0-2) | Fifth | 4½ out |
| Friday, May 7 |
| » Defeated Yankees (9-15), 5-2 | Kingdome (9-3) | 14-15 | Won 3 |
| » W: Floyd Bannister (4-1) L: Mike Morgan (2-1) S: Bill Caudill (4) | Fifth | 3½ out |
| Saturday, May 8 |
| » Lost to Yankees (10-15), 9-4 | Kingdome (9-4) | 14-16 | |
| » W: Ron Guidry (4-1) L: Jim Beattie (0-3) S: Rich Gossage (4) | Fifth | 4½ out |
| Sunday, May 9 |
| » Lost to Yankees (11-15), 3-0 | Kingdome (9-5) | 14-17 | Lost 2 |
| » W: Tommy John (2-4) L: Gene Nelson (1-5) S: Rich Gossage (5) | Fifth | 5½ out |
| Monday, May 10 |
| » Defeated Indians (12-15), 6-4 | Kingdome (10-5) | 15-17 | |
| » W: Ed Vande Berg (3-1) L: Rick Sutcliffe (1-1) S: Bill Caudill (5) | Fifth | 5½ out |
| Tuesday, May 11 |
| » Lost to Indians (13-15), 5-4 | Kingdome (10-6) | 15-18 | |
| » W: Ed Whitson (1-0) L: Bill Caudill (3-1) | Fifth | 5½ out |
| Wednesday, May 12 |
| » Lost to Indians (14-15), 8-5 | Kingdome (10-7) | 15-19 | Lost 2 |
| » W: Rick Sutcliffe (2-1) L: Floyd Bannister (4-2) | Fifth | 6½ out |
| Thursday, May 13 |
| » Lost to Orioles (12-18), 3-1 | Kingdome (10-8) | 15-20 | Lost 3 |
| » W: Dennis Martinez (3-3) L: Jim Beattie (0-4) | Fifth | 7½ out |
| Friday, May 14 |
| » Lost to Orioles (13-18), 11-4 | Kingdome (10-9) | 15-21 | Lost 4 |
| » W: Sammy Stewart (3-2) L: Gene Nelson (1-6) S: Jim Palmer (1) | Fifth | 7½ out |
| Saturday, May 15 |
| » Defeated Orioles (13-19), 3-2 | Kingdome (11-9) | 16-21 | |
| » W: Bill Caudill (4-1) L: Scott McGregor (4-3) | Fifth | 7½ out |
| Sunday, May 16 |
| » Lost to Orioles (14-19), 5-4 | Kingdome (11-10) | 16-22 | |
| » W: Tippy Martinez (1-3) L: Gaylord Perry (3-3) S: Tim Stoddard (1) | Fifth | 8½ out |
| Tuesday, May 18 |
| » Defeated Red Sox (23-13), 3-0 | Fenway Park (1-0) | 17-22 | |
| » W: Floyd Bannister (5-2) L: Dennis Eckersley (4-3) | Fifth | 8½ out |
| Wednesday, May 19 |
| » Lost to Red Sox (24-13), 6-5 | Fenway Park (1-1) | 17-23 | |
| » W: Mark Clear (3-1) L: Bill Caudill (4-2) | Fifth | 9½ out |
| Thursday, May 20 |
| » Lost to Red Sox (25-13), 11-2 | Fenway Park (1-2) | 17-24 | Lost 2 |
| » W: John Tudor (4-1) L: Mike Moore (1-5) | Fifth | 9½ out |
| Friday, May 21 |
| » Lost to Brewers (20-17), 4-1 | County Stadium (0-1) | 17-25 | Lost 3 |
| » W: Bob McClure (2-1) L: Gaylord Perry (3-4) S: Rollie Fingers (9) | Fifth | 10½ out |
| Saturday, May 22 |
| » Defeated Brewers (20-18), 7-1 | County Stadium (1-1) | 18-25 | |
| » W: Gene Nelson (2-6) L: Randy Lerch (3-4) | Fifth | 10½ out |
| Sunday, May 23 |
| » Defeated Brewers (20-19), 6-5 | County Stadium (2-1) | 19-25 | Won 2 |
| » W: Bill Caudill (5-2) L: Rollie Fingers (2-5) | Fifth | 9½ out |
| Tuesday, May 25 |
| » Defeated Tigers (25-15), 7-6 | Kingdome (12-10) | 20-25 | Won 3 |
| » W: Bill Caudill (6-2) L: Elias Sosa (2-2) | Fifth | 9½ out |
| Wednesday, May 26 |
| » Defeated Tigers (25-16), 4-2 | Kingdome (13-10) | 21-25 | Won 4 |
| » W: Gaylord Perry (4-4) L: Jack Morris (6-4) S: Bill Caudill (6) | Fifth | 9 out |
| Thursday, May 27 |
| » Defeated Red Sox (28-15), 10-6 | Kingdome (14-10) | 22-25 | Won 5 |
| » W: Gene Nelson (3-6) L: Mike Torrez (3-3) | Fifth | 8½ out |
| Friday, May 28 |
| » Lost to Red Sox (29-15), 3-2 | Kingdome (14-11) | 22-26 | |
| » W: Dennis Eckersley (6-3) L: Floyd Bannister (5-3) S: Mark Clear (9) | Fifth | 9 out |
| Saturday, May 29 |
| » Defeated Red Sox (29-16), 4-2 | Kingdome (15-11) | 23-26 | |
| » W: Mike Moore (2-5) L: Bruce Hurst (1-1) S: Bill Caudill (7) | Fourth | 9 out |
| Sunday, May 30 |
| » Defeated Red Sox (29-17), 2-1 | Kingdome (16-11) | 24-26 | Won 2 |
| » W: Jim Beattie (1-4) L: John Tudor (4-3) | Fourth | 8 out |
| Monday, May 31 |
| » Defeated Brewers (22-24), 5-4 | Kingdome (17-11) | 25-26 | Won 3 |
| » W: Mike Stanton (1-0) L: Jerry Augustine (0-2) | Fourth | 7 out |
| Tuesday, June 1 |
| » Lost to Brewers (23-24), 2-1 | Kingdome (17-12) | 25-27 | |
| » W: Pete Vuckovich (6-2) L: Gene Nelson (3-7) S: Rollie Fingers (11) | Fourth | 7 out |
| Wednesday, June 2 |
| » Lost to Brewers (24-24), 5-2 | Kingdome (17-13) | 25-28 | Lost 2 |
| » W: Mike Caldwell (3-4) L: Floyd Bannister (5-4) | Fifth | 7 out |
| Friday, June 4 |
| » Defeated Tigers (31-18), 4-0 | Tiger Stadium (1-0) | 26-28 | |
| » W: Jim Beattie (2-4) L: Jack Morris (7-5) | Third | 6 out |
| Sunday, June 6 |
| » Lost to Tigers (32-18), 10-2 | Tiger Stadium (1-1) | 26-29 | |
| » W: Dan Petry (6-3) L: Gaylord Perry (4-5) | Fourth | 5½ out |
| Monday, June 7 |
| » Defeated Rangers (17-31), 6-0 | Arlington Stadium (1-0) | 27-29 | |
| » W: Gene Nelson (4-7) L: Jon Matlack (1-4) | Fourth | 5½ out |
| Tuesday, June 8 |
| » Defeated Rangers (17-32), 2-1 | Arlington Stadium (2-0) | 28-29 | Won 2 |
| » W: Bill Caudill (7-2) L: Paul Mirabella (1-1) S: Larry Andersen (1) | Fourth | 5½ out |
| Wednesday, June 9 |
| » Defeated Rangers (17-33), 4-3 | Arlington Stadium (3-0) | 29-29 | Won 3 |
| » W: Ed Vande Berg (4-1) L: Steve Comer (0-3) | Fourth | 5½ out |
| Friday, June 11 |
| » Lost to Royals (33-22), 3-2 | Royals Stadium (0-1) | 29-30 | |
| » W: Dan Quisenberry (3-2) L: Ed Vande Berg (4-2) | Fourth | 6 out |
| Saturday, June 12 |
| » Defeated Royals (33-23), 3-2 | Royals Stadium (1-1) | 30-30 | |
| » W: Gene Nelson (5-7) L: Keith Creel (1-2) S: Bill Caudill (8) | Fourth | 5 out |
| Sunday, June 13 |
| » Defeated Royals (33-24), 7-1 | Royals Stadium (2-1) | 31-30 | Won 2 |
| » W: Floyd Bannister (6-4) L: Larry Gura (6-3) | Fourth | 4½ out |
| Monday, June 14 |
| » Defeated Rangers (19-34), 4-0 | Kingdome (18-13) | 32-30 | Won 3 |
| » W: Jim Beattie (3-4) L: Jon Matlack (1-5) S: Mike Stanton (4) | Fourth | 4 out |
| Tuesday, June 15 |
| » Lost to Rangers (20-34), 5-2 | Kingdome (18-14) | 32-31 | |
| » W: Frank Tanana (3-7) L: Mike Moore (2-6) S: Steve Comer (3) | Fourth | 5 out |
| Wednesday, June 16 |
| » Defeated Rangers (20-35), 7-2 | Kingdome (19-14) | 33-31 | |
| » W: Gaylord Perry (5-5) L: Charlie Hough (5-4) S: Bill Caudill (9) | Fourth | 4 out |
| Thursday, June 17 |
| » Lost to Rangers (21-35), 5-1 | Kingdome (19-15) | 33-32 | |
| » W: Rick Honeycutt (2-7) L: Gene Nelson (5-8) | Fourth | 5 out |
| Friday, June 18 |
| » Lost to Royals (36-25), 4-1 | Kingdome (19-16) | 33-33 | Lost 2 |
| » W: Larry Gura (7-3) L: Bill Caudill (7-3) S: Dan Quisenberry (18) | Fourth | 6 out |
| Saturday, June 19 |
| » Defeated Royals (36-26), 10-3 | Kingdome (20-16) | 34-33 | |
| » W: Jim Beattie (4-4) L: Keith Creel (1-3) | Fourth | 5 out |
| Sunday, June 20 |
| » Lost to Royals (37-26), 7-5 | Kingdome (20-17) | 34-34 | |
| » W: Paul Splittorff (7-4) L: Gaylord Perry (5-6) S: Dan Quisenberry (19) | Fourth | 6 out |
| Monday, June 21 |
| » Defeated Blue Jays (31-36), 5-4 | Kingdome (21-17) | 35-34 | |
| » W: Mike Moore (3-6) L: Luis Leal (5-5) S: Bill Caudill (10) | Fourth | 6 out |
| Tuesday, June 22 |
| » Defeated Blue Jays (31-37), 6-5 | Kingdome (22-17) | 36-34 | Won 2 |
| » W: Bryan Clark (1-0) L: Roy Lee Jackson (2-6) S: Bill Caudill (11) | Fourth | 5 out |
| Wednesday, June 23 |
| » Lost to Blue Jays (32-37), 5-3 | Kingdome (22-18) | 36-35 | |
| » W: Joey McLaughlin (6-3) L: Mike Stanton (1-1) | Fourth | 6 out |
| Friday, June 25 |
| » Defeated White Sox (38-30), 1-0 | Kingdome (23-18) | 37-35 | |
| » W: Jim Beattie (5-4) L: La Marr Hoyt (10-5) S: Bill Caudill (12) | Fourth | 5½ out |
| Saturday, June 26 |
| » Lost to White Sox (39-30), 13-3 | Kingdome (23-19) | 37-36 | |
| » W: Britt Burns (8-3) L: Gaylord Perry (5-7) | Fourth | 6½ out |
| Sunday, June 27 |
| » Defeated White Sox (39-31), 6-5 | Kingdome (24-19) | 38-36 | |
| » W: Gene Nelson (6-8) L: Steve Trout (5-6) S: Bill Caudill (13) | Fourth | 6½ out |
| Tuesday, June 29 |
| » Defeated Blue Jays (33-39), 4-1 | Exhibition Stadium (1-0) | 39-36 | Won 2 |
| » W: Floyd Bannister (7-4) L: Jim Clancy (7-4) S: Mike Stanton (5) | Fourth | 6½ out |
| Wednesday, June 30 |
| » Defeated Blue Jays (33-40), 10-4 | Exhibition Stadium (2-0) | 40-36 | Won 3 |
| » W: Jim Beattie (6-4) L: Dave Stieb (6-9) | Fourth | 5½ out |
| Thursday, July 1 |
| » Defeated Blue Jays (33-41), 4-3 | Exhibition Stadium (3-0) | 41-36 | Won 4 |
| » W: Gaylord Perry (6-7) L: Luis Leal (5-6) S: Bill Caudill (14) | Fourth | 4½ out |
| Saturday, July 3 |
| » Lost to White Sox (41-34), 7-6 | Comiskey Park I (0-1) | 41-37 | |
| » W: Jerry Koosman (2-3) L: Mike Stanton (1-2) | Fourth | 4 out |
| Sunday, July 4 |
| » Defeated White Sox (41-35), 3-1 | Comiskey Park I (1-1) | 42-37 | |
| » W: Floyd Bannister (8-4) L: Richard Dotson (3-9) S: Bill Caudill (15) | Fourth | 3½ out |
| Monday, July 5 |
| » Defeated Yankees (37-38), 5-4 | Kingdome (25-19) | 43-37 | Won 2 |
| » W: Ed Vande Berg (5-2) L: George Frazier (3-2) S: Bill Caudill (16) | Third | 3 out |
| Tuesday, July 6 |
| » Lost to Yankees (38-38), 8-7 | Kingdome (25-20) | 43-38 | |
| » W: Rudy May (2-3) L: Ed Vande Berg (5-3) | Fourth | 4 out |
| Wednesday, July 7 |
| » Defeated Orioles (42-36), 8-7 | Kingdome (26-20) | 44-38 | |
| » W: Bill Caudill (8-3) L: Tim Stoddard (1-3) | Fourth | 4 out |
| Thursday, July 8 |
| » Defeated Orioles (42-37), 4-3 | Kingdome (27-20) | 45-38 | Won 2 |
| » W: Mike Moore (4-6) L: Mike Flanagan (6-8) S: Bill Caudill (17) | Fourth | 3 out |
| Friday, July 9 |
| » Lost to Indians (39-41), 7-4 | Kingdome (27-21) | 45-39 | |
| » W: John Denny (6-9) L: Floyd Bannister (8-5) S: Dan Spillner (11) | Fourth | 3 out |
| Saturday, July 10 |
| » Lost to Indians (40-41), 7-1 | Kingdome (27-22) | 45-40 | Lost 2 |
| » W: Rick Sutcliffe (7-4) L: Jim Beattie (6-5) | Fourth | 3 out |
| Sunday, July 11 |
| » Lost to Indians (41-41), 4-3 | Kingdome (27-23) | 45-41 | Lost 3 |
| » W: Len Barker (10-5) L: Bill Caudill (8-4) | Fourth | 4 out |
| Thursday, July 15 |
| » Lost to Orioles (45-38), 3-2 | Memorial Stadium (1-2) | 45-42 | Lost 4 |
| » W: Scott McGregor (11-6) L: Jim Beattie (6-6) S: Sammy Stewart (2) | Fourth | 5 out |
| Friday, July 16 |
| » Defeated Orioles (45-39), 6-0 | Memorial Stadium (2-2) | 46-42 | |
| » W: Floyd Bannister (9-5) L: Dennis Martinez (9-7) | Fourth | 5 out |
| Saturday, July 17 |
| » Lost to Orioles (46-39), 8-4 | Memorial Stadium (2-3) | 46-43 | |
| » W: Storm Davis (3-1) L: Gaylord Perry (6-8) | Fourth | 5 out |
| Sunday, July 18 |
| » Lost to Orioles (47-39), 4-3 | Memorial Stadium (2-4) | 46-44 | Lost 2 |
| » W: Sammy Stewart (6-5) L: Mike Moore (4-7) | Fourth | 5 out |
| Monday, July 19 |
| » Lost to Yankees (44-42), 5-3 | Yankee Stadium (1-3) | 46-45 | Lost 3 |
| » W: Tommy John (6-7) L: Gene Nelson (6-9) S: Rich Gossage (17) | Fourth | 6 out |
| Tuesday, July 20 |
| » Defeated Yankees (44-43), 6-5 | Yankee Stadium (2-3) | 47-45 | |
| » W: Bill Caudill (9-4) L: Shane Rawley (5-5) | Fourth | 6 out |
| Wednesday, July 21 |
| » Defeated Yankees (44-44), 6-5 | Yankee Stadium (3-3) | 48-45 | Won 2 |
| » W: Bill Caudill (10-4) L: George Frazier (3-3) | Fourth | 5 out |
| Friday, July 23 |
| » Lost to Indians (45-45), 4-3 | Cleveland Stadium (1-3) | 48-46 | |
| » W: Dan Spillner (7-5) L: Ed Vande Berg (5-4) | Fourth | 5 out |
| Saturday, July 24 |
| » Defeated Indians (45-46), 9-0 | Cleveland Stadium (2-3) | 49-46 | |
| » W: Mike Moore (5-7) L: Len Barker (10-6) | Third | 4 out |
| Sunday, July 25 |
| » Lost to Indians (46-46), 5-3 | Cleveland Stadium (2-4) | 49-47 | |
| » W: Lary Sorensen (8-7) L: Jim Beattie (6-7) S: Dan Spillner (12) | Fourth | 5 out |
| Monday, July 26 |
| » Lost to Twins (34-64), 10-4 | Kingdome (27-24) | 49-48 | Lost 2 |
| » W: Jack O'Connor (4-3) L: Floyd Bannister (9-6) | Fourth | 5 out |
| Tuesday, July 27 |
| » Defeated Twins (34-65), 9-7 | Kingdome (28-24) | 50-48 | |
| » W: Bryan Clark (2-0) L: John Pacella (0-3) S: Bill Caudill (18) | Third | 5 out |
| Wednesday, July 28 |
| » Defeated Twins (34-66), 6-2 | Kingdome (29-24) | 51-48 | Won 2 |
| » W: Gaylord Perry (7-8) L: Bobby Castillo (5-8) S: Mike Stanton (6) | Third | 5 out |
| Thursday, July 29 |
| » Lost to Angels (57-43), 3-1 | Anaheim Stadium (0-4) | 51-49 | |
| » W: Steve Renko (9-2) L: Mike Moore (5-8) S: Luis Sanchez (2) | Third | 6 out |
| Friday, July 30 |
| » Lost to Angels (58-43), 2-0 | Anaheim Stadium (0-5) | 51-50 | Lost 2 |
| » W: Ken Forsch (10-7) L: Jim Beattie (6-8) | Third | 7 out |
| Saturday, July 31 |
| » Defeated Angels (58-44), 9-3 | Anaheim Stadium (1-5) | 52-50 | |
| » W: Floyd Bannister (10-6) L: Dave Goltz (5-4) | Third | 6 out |
| Sunday, August 1 |
| » Lost to Angels (59-44), 9-4 | Anaheim Stadium (1-6) | 52-51 | |
| » W: Geoff Zahn (11-5) L: Rich Bordi (0-1) | Fourth | 7 out |
| Monday, August 2 |
| » Lost to Athletics (45-61), 6-5 | Oakland-Alameda County Stadium (1-3) | 52-52 | Lost 2 |
| » W: Matt Keough (8-15) L: Mike Stanton (1-3) | Fourth | 7 out |
| Tuesday, August 3 |
| » Defeated Athletics (45-62), 3-2 | Oakland-Alameda County Stadium (2-3) | 53-52 | |
| » W: Mike Moore (6-8) L: Rick Langford (8-12) S: Bill Caudill (19) | Fourth | 7 out |
| Wednesday, August 4 |
| » Defeated Athletics (45-63), 5-2 | Oakland-Alameda County Stadium (3-3) | 54-52 | Won 2 |
| » W: Jim Beattie (7-8) L: Brian Kingman (2-9) | Fourth | 6½ out |
| » Lost to Athletics (46-63), 8-3 | Oakland-Alameda County Stadium (3-4) | 54-53 | |
| » W: Steve McCatty (6-1) L: Rich Bordi (0-2) S: Dave Beard (9) | Fourth | 6½ out |
| Friday, August 6 |
| » Lost to Angels (61-47), 11-9 | Kingdome (29-25) | 54-54 | Lost 2 |
| » W: Luis Sanchez (4-2) L: Floyd Bannister (10-7) S: Andy Hassler (3) | Fourth | 7½ out |
| Saturday, August 7 |
| » Lost to Angels (62-47), 3-1 | Kingdome (29-26) | 54-55 | Lost 3 |
| » W: Mike Witt (6-3) L: Gaylord Perry (7-9) | Fourth | 8 out |
| Sunday, August 8 |
| » Lost to Angels (63-47), 9-5 | Kingdome (29-27) | 54-56 | Lost 4 |
| » W: Steve Renko (10-3) L: Mike Moore (6-9) S: Andy Hassler (4) | Fourth | 9 out |
| Monday, August 9 |
| » Lost to Athletics (50-63), 9-4 | Kingdome (29-28) | 54-57 | Lost 5 |
| » W: Brian Kingman (3-9) L: Jim Beattie (7-9) | Fourth | 9½ out |
| Tuesday, August 10 |
| » Defeated Athletics (50-64), 4-2 | Kingdome (30-28) | 55-57 | |
| » W: Ed Vande Berg (6-4) L: Steve McCatty (6-2) | Third | 8½ out |
| Wednesday, August 11 |
| » Defeated Athletics (50-65), 7-4 | Kingdome (31-28) | 56-57 | Won 2 |
| » W: Floyd Bannister (11-7) L: Rick Langford (8-13) S: Bill Caudill (20) | Third | 8½ out |
| Friday, August 13 |
| » Lost to Twins (40-75), 3-1 | Hubert H. Humphrey Metrodome (1-3) | 56-58 | |
| » W: Bobby Castillo (6-9) L: Gaylord Perry (7-10) | Fourth | 10 out |
| Saturday, August 14 |
| » Defeated Twins (40-76), 3-1 | Hubert H. Humphrey Metrodome (2-3) | 57-58 | |
| » W: Mike Stanton (2-3) L: Brad Havens (8-9) S: Bill Caudill (21) | Fourth | 9 out |
| Sunday, August 15 |
| » Defeated Twins (40-77), 10-2 | Hubert H. Humphrey Metrodome (3-3) | 58-58 | Won 2 |
| » W: Jim Beattie (8-9) L: Terry Felton (0-12) | Fourth | 8½ out |
| Monday, August 16 |
| » Lost to Tigers (59-57), 3-1 | Tiger Stadium (1-2) | 58-59 | |
| » W: Jack Morris (14-11) L: Floyd Bannister (11-8) | Fourth | 9 out |
| Tuesday, August 17 |
| » Defeated Tigers (59-58), 5-4 | Tiger Stadium (2-2) | 59-59 | |
| » W: Bryan Clark (3-0) L: Milt Wilcox (7-7) S: Bill Caudill (22) | Fourth | 9½ out |
| » Lost to Tigers (60-58), 3-2 | Tiger Stadium (2-3) | 59-60 | |
| » W: Larry Pashnick (3-4) L: Bob Stoddard (0-1) S: Dave Tobik (7) | Fourth | 9½ out |
| Wednesday, August 18 |
| » Lost to Tigers (61-58), 7-2 | Tiger Stadium (2-4) | 59-61 | Lost 2 |
| » W: Dan Petry (13-7) L: Gaylord Perry (7-11) S: Pat Underwood (2) | Fourth | 9½ out |
| » Major-league debuts: Ron Musselman (Mariners) |
| Friday, August 20 |
| » Lost to Brewers (70-50), 6-5 | Kingdome (31-29) | 59-62 | Lost 3 |
| » W: Mike Caldwell (11-11) L: Mike Moore (6-10) S: Pete Ladd (1) | Third | 10 out |
| Saturday, August 21 |
| » Lost to Brewers (71-50), 3-2 | Kingdome (31-30) | 59-63 | Lost 4 |
| » W: Doc Medich (8-11) L: Bryan Clark (3-1) S: Rollie Fingers (28) | Third | 11 out |
| Sunday, August 22 |
| » Lost to Brewers (72-50), 8-5 | Kingdome (31-31) | 59-64 | Lost 5 |
| » W: Jim Slaton (10-4) L: Floyd Bannister (11-9) | Fourth | 12 out |
| Monday, August 23 |
| » Lost to Red Sox (67-56), 4-3 | Kingdome (31-32) | 59-65 | Lost 6 |
| » W: Mark Clear (10-7) L: Bill Caudill (10-5) | Fourth | 13 out |
| » Major-league debuts: John Moses (Mariners) |
| Tuesday, August 24 |
| » Lost to Red Sox (68-56), 5-4 | Kingdome (31-33) | 59-66 | Lost 7 |
| » W: Tom Burgmeier (7-0) L: Bill Caudill (10-6) | Fourth | 13 out |
| Thursday, August 26 |
| » Defeated Tigers (63-62), 5-4 | Kingdome (32-33) | 60-66 | |
| » W: Bill Caudill (11-6) L: Jack Morris (14-13) | Third | 12½ out |
| Friday, August 27 |
| » Lost to Tigers (64-62), 6-1 | Kingdome (32-34) | 60-67 | |
| » W: Milt Wilcox (8-7) L: Jim Beattie (8-10) S: Dave Tobik (9) | Third | 13½ out |
| Saturday, August 28 |
| » Defeated Tigers (64-63), 4-3 | Kingdome (33-34) | 61-67 | |
| » W: Ron Musselman (1-0) L: Dave Tobik (3-7) | Fourth | 13½ out |
| Sunday, August 29 |
| » Lost to Tigers (65-63), 6-2 | Kingdome (33-35) | 61-68 | |
| » W: Jerry Ujdur (8-7) L: Gaylord Perry (7-12) | Fourth | 14½ out |
| Monday, August 30 |
| » Defeated Brewers (76-53), 3-2 | County Stadium (3-1) | 62-68 | |
| » W: Ed Vande Berg (7-4) L: Jim Slaton (10-5) | Fourth | 14½ out |
| Tuesday, August 31 |
| » Lost to Brewers (77-53), 8-2 | County Stadium (3-2) | 62-69 | |
| » W: Mike Caldwell (13-11) L: Bryan Clark (3-2) | Fourth | 14½ out |
| Wednesday, September 1 |
| » Lost to Brewers (78-53), 7-3 | County Stadium (3-3) | 62-70 | Lost 2 |
| » W: Doc Medich (10-11) L: Mike Stanton (2-4) | Fourth | 14½ out |
| Friday, September 3 |
| » Lost to Red Sox (75-58), 10-8 | Fenway Park (1-3) | 62-71 | Lost 3 |
| » W: John Tudor (10-9) L: Floyd Bannister (11-10) S: Bob Stanley (12) | Fourth | 15½ out |
| Saturday, September 4 |
| » Defeated Red Sox (75-59), 4-3 | Fenway Park (2-3) | 63-71 | |
| » W: Gaylord Perry (8-12) L: Bruce Hurst (3-7) S: Bill Caudill (23) | Fourth | 14½ out |
| Sunday, September 5 |
| » Lost to Red Sox (76-59), 6-5 | Fenway Park (2-4) | 63-72 | |
| » W: Mark Clear (13-7) L: Bill Caudill (11-7) | Fourth | 14½ out |
| Monday, September 6 |
| » Defeated Royals (78-59), 6-2 | Kingdome (34-35) | 64-72 | |
| » W: Floyd Bannister (12-10) L: Bud Black (4-6) | Fourth | 13½ out |
| Tuesday, September 7 |
| » Defeated Royals (78-60), 5-2 | Kingdome (35-35) | 65-72 | Won 2 |
| » W: Mike Moore (7-10) L: Paul Splittorff (9-9) S: Bill Caudill (24) | Fourth | 12½ out |
| Wednesday, September 8 |
| » Lost to Royals (79-60), 6-2 | Kingdome (35-36) | 65-73 | |
| » W: Vida Blue (12-9) L: Jim Beattie (8-11) | Fourth | 13½ out |
| Friday, September 10 |
| » Defeated Rangers (56-84), 5-2 | Arlington Stadium (4-0) | 66-73 | |
| » W: Gaylord Perry (9-12) L: Frank Tanana (6-17) S: Ed Vande Berg (3) | Fourth | 12½ out |
| » Major-league debuts: Tom Henke (Rangers) |
| Saturday, September 11 |
| » Lost to Rangers (57-84), 5-2 | Arlington Stadium (4-1) | 66-74 | |
| » W: Charlie Hough (14-11) L: Floyd Bannister (12-11) | Fourth | 13½ out |
| Sunday, September 12 |
| » Defeated Rangers (57-85), 1-0 | Arlington Stadium (5-1) | 67-74 | |
| » W: Bob Stoddard (1-1) L: Mike Smithson (2-2) S: Bill Caudill (25) | Fourth | 13½ out |
| Monday, September 13 |
| » Lost to Royals (82-61), 8-0 | Royals Stadium (2-2) | 67-75 | |
| » W: Vida Blue (13-9) L: Mike Moore (7-11) | Fourth | 14½ out |
| » Major-league debuts: Orlando Mercado (Mariners) |
| Tuesday, September 14 |
| » Lost to Royals (83-61), 5-2 | Royals Stadium (2-3) | 67-76 | Lost 2 |
| » W: Bill Castro (2-1) L: Jim Beattie (8-12) S: Bob Tufts (1) | Fourth | 15½ out |
| Wednesday, September 15 |
| » Lost to Royals (84-61), 5-4 | Royals Stadium (2-4) | 67-77 | Lost 3 |
| » W: Dan Quisenberry (8-5) L: Bill Caudill (11-8) | Fourth | 16½ out |
| Thursday, September 16 |
| » Defeated Royals (84-62), 4-2 | Royals Stadium (3-4) | 68-77 | |
| » W: Ed Vande Berg (8-4) L: Dennis Leonard (10-5) S: Mike Stanton (7) | Fourth | 15½ out |
| Friday, September 17 |
| » Defeated Rangers (58-89), 6-0 | Kingdome (36-36) | 69-77 | Won 2 |
| » W: Bob Stoddard (2-1) L: Mike Smithson (2-3) | Fourth | 14½ out |
| Saturday, September 18 |
| » Lost to Rangers (59-89), 10-4 | Kingdome (36-37) | 69-78 | |
| » W: Mike Mason (1-1) L: Mike Moore (7-12) S: John Butcher (1) | Fourth | 14½ out |
| Sunday, September 19 |
| » Defeated Rangers (59-90), 9-7 | Kingdome (37-37) | 70-78 | |
| » W: Edwin Nunez (1-1) L: Rick Honeycutt (5-16) S: Bill Caudill (26) | Third | 13½ out |
| Monday, September 20 |
| » Defeated White Sox (79-70), 5-2 | Kingdome (38-37) | 71-78 | Won 2 |
| » W: Bryan Clark (4-2) L: La Marr Hoyt (16-15) S: Ed Vande Berg (4) | Fourth | 13½ out |
| Tuesday, September 21 |
| » Defeated White Sox (79-71), 5-4 | Kingdome (39-37) | 72-78 | Won 3 |
| » W: Bill Caudill (12-8) L: Kevin Hickey (4-4) | Fourth | 13½ out |
| Wednesday, September 22 |
| » Defeated White Sox (79-72), 8-4 | Kingdome (40-37) | 73-78 | Won 4 |
| » W: Bob Stoddard (3-1) L: Richard Dotson (11-13) S: Ed Vande Berg (5) | Fourth | 13½ out |
| Thursday, September 23 |
| » Lost to White Sox (80-72), 12-4 | Kingdome (40-38) | 73-79 | |
| » W: Jerry Koosman (11-6) L: Mike Moore (7-13) | Fourth | 13½ out |
| Friday, September 24 |
| » Defeated Blue Jays (71-82), 3-2 | Kingdome (41-38) | 74-79 | |
| » W: Ed Vande Berg (9-4) L: Dale Murray (8-7) | Fourth | 13½ out |
| Saturday, September 25 |
| » Defeated Blue Jays (71-83), 7-0 | Kingdome (42-38) | 75-79 | Won 2 |
| » W: Bryan Clark (5-2) L: Luis Leal (11-15) | Fourth | 13½ out |
| Sunday, September 26 |
| » Lost to Blue Jays (72-83), 6-2 | Kingdome (42-39) | 75-80 | |
| » W: Dave Stieb (16-14) L: Floyd Bannister (12-12) | Fourth |
