| Monday, March 15 |
| Former Cub Eddie Mulligan dies in San Rafael, CA at the age of 88. |
| Monday, April 5 |
| » Defeated Reds (0-1), 3-2 | Riverfront Stadium (1-0) | 1-0 | |
| » W: Doug Bird (1-0) L: Mario Soto (0-1) S: Willie Hernandez (1) | First | -- |
| Wednesday, April 7 |
| » Lost to Reds (1-1), 6-2 | Riverfront Stadium (1-1) | 1-1 | |
| » W: Bruce Berenyi (1-0) L: Dickie Noles (0-1) S: Tom Hume (1) | Second | 1 out |
| Friday, April 9 |
| » Defeated Mets (1-1), 5-0 | Wrigley Field (1-0) | 2-1 | |
| » W: Fergie Jenkins (1-0) L: Mike Scott (0-1) S: Lee Smith (1) | Second | 1 out |
| » Major-league debuts: Gary Rajsich (Mets) |
| Saturday, April 10 |
| » Lost to Mets (2-1), 9-5 | Wrigley Field (1-1) | 2-2 | |
| » W: Pat Zachry (1-0) L: Doug Bird (1-1) | Fourth | 1 out |
| Sunday, April 11 |
| » Lost to Mets (3-1), 5-4 | Wrigley Field (1-2) | 2-3 | Lost 2 |
| » W: Pete Falcone (1-0) L: Dan Larson (0-1) S: Neil Allen (1) | Fourth | 1½ out |
| Monday, April 12 |
| » Defeated Mets (3-2), 5-4 | Wrigley Field (2-2) | 3-3 | |
| » W: Dickie Noles (1-1) L: Craig Swan (0-1) S: Bill Campbell (1) | Third | 1½ out |
| Tuesday, April 13 |
| » Lost to Cardinals (4-3), 4-3 | Wrigley Field (2-3) | 3-4 | |
| » W: Joaquin Andujar (1-1) L: Randy Martz (0-1) S: Bruce Sutter (2) | Fourth | 1½ out |
| Wednesday, April 14 |
| » Lost to Cardinals (5-3), 3-1 | Wrigley Field (2-4) | 3-5 | Lost 2 |
| » W: Andy Rincon (1-0) L: Fergie Jenkins (1-1) | Fourth | 2 out |
| Thursday, April 15 |
| » Lost to Cardinals (6-3), 6-1 | Wrigley Field (2-5) | 3-6 | Lost 3 |
| » W: Steve Mura (1-0) L: Doug Bird (1-2) | Fifth | 3 out |
| Friday, April 16 |
| » Lost to Pirates (3-3), 7-6 | Three Rivers Stadium (0-1) | 3-7 | Lost 4 |
| » W: Enrique Romo (1-1) L: Willie Hernandez (0-1) | Fifth | 4 out |
| Saturday, April 17 |
| » Defeated Pirates (3-4), 10-2 | Three Rivers Stadium (1-1) | 4-7 | |
| » W: Dickie Noles (2-1) L: Ross Baumgarten (0-1) | Fifth | 4 out |
| Sunday, April 18 |
| » Defeated Pirates (3-5), 5-1 | Three Rivers Stadium (2-1) | 5-7 | Won 2 |
| » W: Fergie Jenkins (2-1) L: Eddie Solomon (0-2) S: Randy Martz (1) | Fourth | 4 out |
| Tuesday, April 20 |
| » Lost to Mets (7-5), 3-2 | Shea Stadium (0-1) | 5-8 | |
| » W: Mike Scott (2-1) L: Doug Bird (1-3) S: Neil Allen (3) | Fourth | 5 out |
| Wednesday, April 21 |
| » Lost to Mets (8-5), 7-4 | Shea Stadium (0-2) | 5-9 | Lost 2 |
| » W: Craig Swan (1-1) L: Bill Campbell (0-1) S: Neil Allen (4) | Fourth | 6 out |
| Friday, April 23 |
| » Lost to Pirates (4-7), 12-10 | Wrigley Field (2-6) | 5-10 | Lost 3 |
| » W: Eddie Solomon (1-2) L: Dickie Noles (2-2) S: Kent Tekulve (1) | Fifth | 7 out |
| Saturday, April 24 |
| » Lost to Pirates (5-7), 8-5 | Wrigley Field (2-7) | 5-11 | Lost 4 |
| » W: Don Robinson (1-0) L: Randy Martz (0-2) | Fifth | 8 out |
| Sunday, April 25 |
| » Defeated Pirates (5-8), 5-3 | Wrigley Field (3-7) | 6-11 | |
| » W: Randy Martz (1-2) L: Rick Rhoden (0-2) | Fifth | 7 out |
| Tuesday, April 27 |
| » Lost to Reds (7-11), 6-3 | Wrigley Field (3-8) | 6-12 | |
| » W: Bruce Berenyi (4-1) L: Dan Larson (0-2) S: Jim Kern (1) | Fifth | 6½ out |
| Wednesday, April 28 |
| » Defeated Reds (7-12), 6-0 | Wrigley Field (4-8) | 7-12 | |
| » W: Dickie Noles (3-2) L: Tom Seaver (0-3) | Fifth | 6½ out |
| Thursday, April 29 |
| » Lost to Braves (15-5), 3-0 | Atlanta-Fulton County Stadium (0-1) | 7-13 | |
| » W: Gene Garber (2-1) L: Fergie Jenkins (2-2) S: Rick Camp (4) | Fifth | 7 out |
| Friday, April 30 |
| » Lost to Braves (16-5), 1-0 | Atlanta-Fulton County Stadium (0-2) | 7-14 | Lost 2 |
| » W: Steve Bedrosian (2-0) L: Doug Bird (1-4) S: Gene Garber (4) | Fifth | 7 out |
| Saturday, May 1 |
| » Defeated Braves (16-6), 5-1 | Atlanta-Fulton County Stadium (1-2) | 8-14 | |
| » W: Randy Martz (2-2) L: Rick Mahler (2-1) | Fifth | 6 out |
| Sunday, May 2 |
| » Lost to Braves (17-6), 10-3 | Atlanta-Fulton County Stadium (1-3) | 8-15 | |
| » W: Bob Walk (3-2) L: Dan Larson (0-3) | Fifth | 6½ out |
| Monday, May 3 |
| » Lost to Cardinals (16-9), 9-4 | Busch Stadium II (0-1) | 8-16 | Lost 2 |
| » W: Doug Bair (2-0) L: Dickie Noles (3-3) | Sixth | 7½ out |
| Tuesday, May 4 |
| » Lost to Cardinals (17-9), 7-4 | Busch Stadium II (0-2) | 8-17 | Lost 3 |
| » W: Joaquin Andujar (3-2) L: Fergie Jenkins (2-3) S: Bruce Sutter (9) | Sixth | 8½ out |
| Wednesday, May 5 |
| » Lost to Cardinals (18-9), 7-6 | Busch Stadium II (0-3) | 8-18 | Lost 4 |
| » W: Doug Bair (3-0) L: Willie Hernandez (0-2) S: Bruce Sutter (10) | Sixth | 9½ out |
| Friday, May 7 |
| » Defeated Astros (12-16), 12-6 | Wrigley Field (5-8) | 9-18 | |
| » W: Randy Martz (3-2) L: Nolan Ryan (2-5) | Sixth | 8½ out |
| Saturday, May 8 |
| » Defeated Astros (12-17), 3-2 | Wrigley Field (6-8) | 10-18 | Won 2 |
| » W: Dickie Noles (4-3) L: Joe Niekro (3-2) S: Bill Campbell (2) | Sixth | 8½ out |
| Sunday, May 9 |
| » Defeated Astros (12-18), 6-3 | Wrigley Field (7-8) | 11-18 | Won 3 |
| » W: Willie Hernandez (1-2) L: Randy Moffitt (0-2) | Sixth | 7½ out |
| Monday, May 10 |
| » Major-league debuts: Willie McGee (Cardinals) |
| Tuesday, May 11 |
| » Defeated Braves (20-10), 6-4 | Wrigley Field (8-8) | 12-18 | Won 4 |
| » W: Doug Bird (2-4) L: Rick Mahler (2-3) S: Willie Hernandez (2) | Sixth | 7 out |
| Wednesday, May 12 |
| » Lost to Braves (21-10), 6-3 | Wrigley Field (8-9) | 12-19 | |
| » W: Bob Walk (4-2) L: Randy Martz (3-3) S: Gene Garber (7) | Sixth | 7½ out |
| Thursday, May 13 |
| » Defeated Astros (14-19), 5-0 | Astrodome (1-0) | 13-19 | |
| » W: Allen Ripley (1-0) L: Joe Niekro (3-3) S: Lee Smith (2) | Sixth | 7½ out |
| Friday, May 14 |
| » Defeated Astros (14-20), 6-3 | Astrodome (2-0) | 14-19 | Won 2 |
| » W: Dickie Noles (5-3) L: Bob Knepper (1-4) S: Willie Hernandez (3) | Sixth | 6½ out |
| Saturday, May 15 |
| » Lost to Astros (15-20), 4-1 | Astrodome (2-1) | 14-20 | |
| » W: Don Sutton (6-1) L: Fergie Jenkins (2-4) | Sixth | 7½ out |
| Sunday, May 16 |
| » Defeated Astros (15-21), 2-1 | Astrodome (3-1) | 15-20 | |
| » W: Doug Bird (3-4) L: Nolan Ryan (3-6) S: Willie Hernandez (4) | Sixth | 6½ out |
| Tuesday, May 18 |
| » Lost to Dodgers (18-19), 2-1 | Dodger Stadium (0-1) | 15-21 | |
| » W: Tom Niedenfuer (1-1) L: Bill Campbell (0-2) | Sixth | 7½ out |
| Wednesday, May 19 |
| » Lost to Dodgers (19-19), 4-1 | Dodger Stadium (0-2) | 15-22 | Lost 2 |
| » W: Dave Stewart (1-2) L: Dickie Noles (5-4) S: Tom Niedenfuer (4) | Sixth | 7½ out |
| Thursday, May 20 |
| » Defeated Dodgers (19-20), 8-3 | Dodger Stadium (1-2) | 16-22 | |
| » W: Fergie Jenkins (3-4) L: Fernando Valenzuela (5-4) | Sixth | 7½ out |
| Friday, May 21 |
| » Defeated Giants (17-23), 6-4 | Candlestick Park (1-0) | 17-22 | Won 2 |
| » W: Dick Tidrow (1-0) L: Renie Martin (0-1) S: Bill Campbell (3) | Fifth | 7½ out |
| Saturday, May 22 |
| » Defeated Giants (17-24), 2-1 | Candlestick Park (2-0) | 18-22 | Won 3 |
| » W: Allen Ripley (2-0) L: Atlee Hammaker (2-2) S: Willie Hernandez (5) | Fifth | 6½ out |
| Sunday, May 23 |
| » Lost to Giants (18-24), 4-3 | Candlestick Park (2-1) | 18-23 | |
| » W: Gary Lavelle (3-2) L: Dick Tidrow (1-1) | Fifth | 7 out |
| » Lost to Giants (19-24), 6-3 | Candlestick Park (2-2) | 18-24 | Lost 2 |
| » W: Dan Schatzeder (1-4) L: Dan Larson (0-4) S: Jim Barr (2) | Fifth | 7 out |
| Monday, May 24 |
| » Lost to Padres (22-18), 8-2 | San Diego/Jack Murphy Stadium (0-1) | 18-25 | Lost 3 |
| » W: Tim Lollar (5-0) L: Dickie Noles (5-5) | Sixth | 8 out |
| Tuesday, May 25 |
| » Lost to Padres (23-18), 2-1 | San Diego/Jack Murphy Stadium (0-2) | 18-26 | Lost 4 |
| » W: Chris Welsh (2-1) L: Fergie Jenkins (3-5) S: Floyd Chiffer (2) | Sixth | 9 out |
| Wednesday, May 26 |
| » Defeated Padres (23-19), 5-3 | San Diego/Jack Murphy Stadium (1-2) | 19-26 | |
| » W: Willie Hernandez (2-2) L: Luis DeLeon (2-2) S: Bill Campbell (4) | Fifth | 9 out |
| Friday, May 28 |
| » Defeated Dodgers (23-23), 4-3 | Wrigley Field (9-9) | 20-26 | Won 2 |
| » W: Randy Martz (4-3) L: Bob Welch (5-3) S: Bill Campbell (5) | Fifth | 9 out |
| Saturday, May 29 |
| » Defeated Dodgers (23-24), 3-2 | Wrigley Field (10-9) | 21-26 | Won 3 |
| » W: Lee Smith (1-0) L: Alejandro Pena (0-1) | Fifth | 8 out |
| Sunday, May 30 |
| » Lost to Dodgers (24-24), 7-0 | Wrigley Field (10-10) | 21-27 | |
| » W: Fernando Valenzuela (7-4) L: Fergie Jenkins (3-6) | Fifth | 9 out |
| Monday, May 31 |
| » Lost to Padres (25-21), 9-7 | Wrigley Field (10-11) | 21-28 | Lost 2 |
| » W: Chris Welsh (3-1) L: Doug Bird (3-5) S: Luis DeLeon (2) | Fifth | 10 out |
| Tuesday, June 1 |
| » Lost to Padres (26-21), 9-1 | Wrigley Field (10-12) | 21-29 | Lost 3 |
| » W: John Montefusco (3-4) L: Randy Martz (4-4) S: Eric Show (2) | Fifth | 10 out |
| Wednesday, June 2 |
| » Lost to Padres (27-21), 3-1 | Wrigley Field (10-13) | 21-30 | Lost 4 |
| » W: Juan Eichelberger (5-6) L: Dickie Noles (5-6) | Sixth | 11 out |
| Friday, June 4 |
| » Lost to Giants (23-30), 4-3 | Wrigley Field (10-14) | 21-31 | Lost 5 |
| » W: Fred Breining (3-1) L: Fergie Jenkins (3-7) S: Greg Minton (7) | Sixth | 12 out |
| Former Cub Tony Kaufmann dies in Elgin, IL at the age of 82. |
| Saturday, June 5 |
| » Lost to Giants (24-30), 2-1 | Wrigley Field (10-15) | 21-32 | Lost 6 |
| » W: Rich Gale (2-4) L: Doug Bird (3-6) S: Greg Minton (8) | Sixth | 12 out |
| Sunday, June 6 |
| » Lost to Giants (25-30), 5-3 | Wrigley Field (10-16) | 21-33 | Lost 7 |
| » W: Renie Martin (1-3) L: Randy Martz (4-5) S: Greg Minton (9) | Sixth | 12 out |
| Monday, June 7 |
| » Lost to Phillies (28-24), 7-5 | Veteran's Stadium (0-1) | 21-34 | Lost 8 |
| » W: Sid Monge (3-0) L: Lee Smith (1-1) S: Ed Farmer (6) | Sixth | 12 out |
| Tuesday, June 8 |
| » Lost to Phillies (29-24), 5-2 | Veteran's Stadium (0-2) | 21-35 | Lost 9 |
| » W: Marty Bystrom (1-0) L: Tom Filer (0-1) S: Sparky Lyle (2) | Sixth | 13 out |
| Wednesday, June 9 |
| » Lost to Phillies (30-24), 4-2 | Veteran's Stadium (0-3) | 21-36 | Lost 10 |
| » W: Steve Carlton (7-6) L: Fergie Jenkins (3-8) | Sixth | 13 out |
| Friday, June 11 |
| » Lost to Expos (29-24), 9-8 | Stade Olympique (0-1) | 21-37 | Lost 11 |
| » W: Woodie Fryman (3-2) L: Bill Campbell (0-3) S: Jeff Reardon (9) | Sixth | 14 out |
| Saturday, June 12 |
| » Lost to Expos (30-24), 7-5 | Stade Olympique (0-2) | 21-38 | Lost 12 |
| » W: Ray Burris (2-7) L: Willie Hernandez (2-3) S: Jeff Reardon (10) | Sixth | 14 out |
| Sunday, June 13 |
| » Lost to Expos (31-24), 5-3 | Stade Olympique (0-3) | 21-39 | Lost 13 |
| » W: Woodie Fryman (4-2) L: Willie Hernandez (2-4) | Sixth | 14½ out |
| Monday, June 14 |
| » Defeated Phillies (30-27), 12-11 | Wrigley Field (11-16) | 22-39 | |
| » W: Fergie Jenkins (4-8) L: Steve Carlton (7-7) | Sixth | 14½ out |
| Tuesday, June 15 |
| » Defeated Phillies (30-28), 8-5 | Wrigley Field (12-16) | 23-39 | Won 2 |
| » W: Doug Bird (4-6) L: Dick Ruthven (5-4) S: Mike Proly (1) | Sixth | 14½ out |
| Wednesday, June 16 |
| » Defeated Phillies (30-29), 7-6 | Wrigley Field (13-16) | 24-39 | Won 3 |
| » W: Dick Tidrow (2-1) L: Warren Brusstar (2-3) | Sixth | 13½ out |
| Thursday, June 17 |
| » Defeated Expos (32-27), 12-8 | Wrigley Field (14-16) | 25-39 | Won 4 |
| » W: Mike Proly (1-0) L: David Palmer (1-1) | Fifth | 13 out |
| Friday, June 18 |
| » Lost to Expos (33-27), 4-0 | Wrigley Field (14-17) | 25-40 | |
| » W: Steve Rogers (8-3) L: Tom Filer (0-2) | Sixth | 13½ out |
| Saturday, June 19 |
| » Lost to Expos (34-27), 5-2 | Wrigley Field (14-18) | 25-41 | Lost 2 |
| » W: Ray Burris (3-8) L: Willie Hernandez (2-5) S: Jeff Reardon (11) | Sixth | 13½ out |
| Sunday, June 20 |
| » Lost to Expos (35-27), 11-5 | Wrigley Field (14-19) | 25-42 | Lost 3 |
| » W: Scott Sanderson (6-4) L: Doug Bird (4-7) | Sixth | 13½ out |
| Monday, June 21 |
| » Lost to Pirates (29-33), 4-3 | Three Rivers Stadium (2-2) | 25-43 | Lost 4 |
| » W: Paul Moskau (1-3) L: Lee Smith (1-2) S: Kent Tekulve (8) | Sixth | 14½ out |
| Tuesday, June 22 |
| » Lost to Pirates (30-33), 9-2 | Three Rivers Stadium (2-3) | 25-44 | Lost 5 |
| » W: John Candelaria (3-3) L: Randy Martz (4-6) S: Enrique Romo (1) | Sixth | 15½ out |
| Wednesday, June 23 |
| » Defeated Pirates (30-34), 6-5 | Three Rivers Stadium (3-3) | 26-44 | |
| » W: Bill Campbell (1-3) L: Randy Niemann (0-1) | Sixth | 14½ out |
| Friday, June 25 |
| » Defeated Cardinals (40-31), 5-3 | Wrigley Field (15-19) | 27-44 | Won 2 |
| » W: Fergie Jenkins (5-8) L: Joaquin Andujar (6-5) | Sixth | 13 out |
| Saturday, June 26 |
| » Lost to Cardinals (41-31), 4-1 | Wrigley Field (15-20) | 27-45 | |
| » W: Dave LaPoint (4-1) L: Doug Bird (4-8) S: Bruce Sutter (16) | Sixth | 15 out |
| » Lost to Cardinals (42-31), 2-1 | Wrigley Field (15-21) | 27-46 | Lost 2 |
| » W: Jim Kaat (2-1) L: Lee Smith (1-3) S: Bruce Sutter (17) | Sixth | 15 out |
| Sunday, June 27 |
| » Defeated Cardinals (42-32), 4-2 | Wrigley Field (16-21) | 28-46 | |
| » W: Allen Ripley (3-0) L: John Stuper (2-1) S: Bill Campbell (6) | Sixth | 14 out |
| » Major-league debuts: Jeff Lahti (Cardinals) |
| Monday, June 28 |
| » Defeated Pirates (33-36), 6-4 | Wrigley Field (17-21) | 29-46 | Won 2 |
| » W: Dick Tidrow (3-1) L: Enrique Romo (4-2) | Sixth | 13 out |
| Tuesday, June 29 |
| » Lost to Pirates (34-36), 3-1 | Wrigley Field (17-22) | 29-47 | |
| » W: Rick Rhoden (5-6) L: Fergie Jenkins (5-9) | Sixth | 14 out |
| Wednesday, June 30 |
| » Lost to Pirates (35-36), 7-3 | Wrigley Field (17-23) | 29-48 | Lost 2 |
| » W: Don Robinson (8-3) L: Lee Smith (1-4) S: Rod Scurry (4) | Sixth | 14 out |
| Thursday, July 1 |
| » Lost to Pirates (36-36), 5-2 | Wrigley Field (17-24) | 29-49 | Lost 3 |
| » W: Enrique Romo (5-2) L: Bill Campbell (1-4) | Sixth | 14½ out |
| Former Cub Footsie Blair dies in Texarkana, TX at the age of 82. |
| Friday, July 2 |
| » Defeated Cardinals (43-35), 4-3 | Busch Stadium II (1-3) | 30-49 | |
| » W: Ken Kravec (1-0) L: Dave LaPoint (4-2) S: Dick Tidrow (1) | Sixth | 13½ out |
| Saturday, July 3 |
| » Defeated Cardinals (43-36), 2-1 | Busch Stadium II (2-3) | 31-49 | Won 2 |
| » W: Tom Filer (1-2) L: Joaquin Andujar (7-6) S: Willie Hernandez (6) | Sixth | 13 out |
| Sunday, July 4 |
| » Lost to Cardinals (44-36), 7-2 | Busch Stadium II (2-4) | 31-50 | |
| » W: John Stuper (3-1) L: Dickie Noles (5-7) S: Bruce Sutter (18) | Sixth | 14½ out |
| Monday, July 5 |
| » Lost to Braves (49-29), 7-5 | Atlanta-Fulton County Stadium (1-4) | 31-51 | Lost 2 |
| » W: Al Hrabosky (2-0) L: Lee Smith (1-5) S: Gene Garber (15) | Sixth | 14½ out |
| Tuesday, July 6 |
| » Defeated Braves (49-30), 7-2 | Atlanta-Fulton County Stadium (2-4) | 32-51 | |
| » W: Doug Bird (5-8) L: Ken Dayley (4-5) S: Willie Hernandez (7) | Sixth | 14½ out |
| Wednesday, July 7 |
| » Lost to Astros (35-46), 5-1 | Astrodome (3-2) | 32-52 | |
| » W: Don Sutton (9-4) L: Allen Ripley (3-1) | Sixth | 14½ out |
| Thursday, July 8 |
| » Defeated Astros (35-47), 5-3 | Astrodome (4-2) | 33-52 | |
| » W: Dick Tidrow (4-1) L: Vern Ruhle (5-6) S: Willie Hernandez (8) | Sixth | 14½ out |
| Friday, July 9 |
| » Defeated Reds (32-51), 12-0 | Wrigley Field (18-24) | 34-52 | Won 2 |
| » W: Fergie Jenkins (6-9) L: Bob Shirley (2-7) | Sixth | 14½ out |
| Saturday, July 10 |
| » Defeated Reds (32-52), 1-0 | Wrigley Field (19-24) | 35-52 | Won 3 |
| » W: Dickie Noles (6-7) L: Bruce Berenyi (5-9) | Sixth | 13½ out |
| Sunday, July 11 |
| » Defeated Reds (32-53), 9-2 | Wrigley Field (20-24) | 36-52 | Won 4 |
| » W: Doug Bird (6-8) L: Tom Seaver (4-10) | Sixth | 13 out |
| » Lost to Reds (33-53), 6-5 | Wrigley Field (20-25) | 36-53 | |
| » W: Mario Soto (8-5) L: Mike Proly (1-1) | Sixth | 13 out |
| Thursday, July 15 |
| » Lost to Braves (52-33), 11-4 | Wrigley Field (20-26) | 36-54 | Lost 2 |
| » W: Phil Niekro (7-3) L: Fergie Jenkins (6-10) | Sixth | 14 out |
| Friday, July 16 |
| » Defeated Braves (52-34), 4-3 | Wrigley Field (21-26) | 37-54 | |
| » W: Bill Campbell (2-4) L: Gene Garber (6-4) | Sixth | 14 out |
| Saturday, July 17 |
| » Lost to Braves (53-34), 9-4 | Wrigley Field (21-27) | 37-55 | |
| » W: Bob Walk (8-6) L: Dickie Noles (6-8) | Sixth | 15 out |
| Sunday, July 18 |
| » Lost to Braves (54-34), 4-2 | Wrigley Field (21-28) | 37-56 | Lost 2 |
| » W: Rick Camp (7-3) L: Doug Bird (6-9) | Sixth | 15 out |
| Monday, July 19 |
| » Defeated Astros (40-50), 6-5 | Wrigley Field (22-28) | 38-56 | |
| » W: Lee Smith (2-5) L: Frank LaCorte (0-3) | Sixth | 15 out |
| Tuesday, July 20 |
| » Defeated Astros (40-51), 5-3 | Wrigley Field (23-28) | 39-56 | Won 2 |
| » W: Willie Hernandez (3-5) L: Don Sutton (9-6) S: Dick Tidrow (2) | Sixth | 14 out |
| Wednesday, July 21 |
| » Lost to Astros (41-51), 2-1 | Wrigley Field (23-29) | 39-57 | |
| » W: Nolan Ryan (10-9) L: Allen Ripley (3-2) S: Frank LaCorte (2) | Sixth | 15 out |
| Friday, July 23 |
| » Defeated Reds (34-60), 7-5 | Riverfront Stadium (2-1) | 40-57 | |
| » W: Willie Hernandez (4-5) L: Jim Kern (1-4) S: Lee Smith (3) | Sixth | 15 out |
| Former Cub Roberto Pena dies in Santiago, D.R. at the age of 46. |
| Saturday, July 24 |
| » Lost to Reds (35-60), 5-2 | Riverfront Stadium (2-2) | 40-58 | |
| » W: Frank Pastore (5-7) L: Doug Bird (6-10) S: Joe Price (1) | Sixth | 15 out |
| Sunday, July 25 |
| » Lost to Reds (36-60), 2-1 | Riverfront Stadium (2-3) | 40-59 | Lost 2 |
| » W: Bruce Berenyi (7-10) L: Fergie Jenkins (6-11) | Sixth | 16 out |
| Monday, July 26 |
| » Lost to Reds (37-60), 4-2 | Riverfront Stadium (2-4) | 40-60 | Lost 3 |
| » W: Bob Shirley (3-7) L: Allen Ripley (3-3) S: Tom Hume (17) | Sixth | 16½ out |
| Tuesday, July 27 |
| » Lost to Expos (50-46), 4-3 | Wrigley Field (23-30) | 40-61 | Lost 4 |
| » W: Steve Rogers (13-4) L: Randy Martz (4-7) | Sixth | 17½ out |
| Wednesday, July 28 |
| » Lost to Expos (51-46), 5-3 | Wrigley Field (23-31) | 40-62 | Lost 5 |
| » W: Bill Gullickson (8-8) L: Dickie Noles (6-9) | Sixth | 18½ out |
| Thursday, July 29 |
| » Lost to Phillies (56-42), 3-2 | Veteran's Stadium (0-4) | 40-63 | Lost 6 |
| » W: Mike Krukow (10-6) L: Dick Tidrow (4-2) S: Ron Reed (5) | Sixth | 18½ out |
| Friday, July 30 |
| » Lost to Phillies (57-42), 3-1 | Veteran's Stadium (0-5) | 40-64 | Lost 7 |
| » W: Steve Carlton (14-8) L: Fergie Jenkins (6-12) | Sixth | 19½ out |
| Saturday, July 31 |
| » Lost to Phillies (58-42), 2-0 | Veteran's Stadium (0-6) | 40-65 | Lost 8 |
| » W: Marty Bystrom (3-3) L: Allen Ripley (3-4) S: Porfi Altamirano (1) | Sixth | 20½ out |
| Sunday, August 1 |
| » Defeated Phillies (58-43), 7-2 | Veteran's Stadium (1-6) | 41-65 | |
| » W: Dickie Noles (7-9) L: Dick Ruthven (8-9) | Sixth | 19½ out |
| Tuesday, August 3 |
| » Defeated Mets (45-58), 5-0 | Wrigley Field (24-31) | 42-65 | Won 2 |
| » W: Doug Bird (7-10) L: Brent Gaff (0-3) | Sixth | 20 out |
| Wednesday, August 4 |
| » Lost to Mets (46-58), 7-4 | Wrigley Field (24-32) | 42-66 | |
| » W: Craig Swan (7-4) L: Fergie Jenkins (6-13) S: Pete Falcone (2) | Sixth | 21 out |
| Thursday, August 5 |
| » Defeated Mets (46-59), 5-1 | Wrigley Field (25-32) | 43-66 | |
| » W: Randy Martz (5-7) L: Charlie Puleo (8-8) | Sixth | 20 out |
| Friday, August 6 |
| » Defeated Phillies (61-45), 4-2 | Wrigley Field (26-32) | 44-66 | Won 2 |
| » W: Allen Ripley (4-4) L: Dick Ruthven (8-10) S: Lee Smith (4) | Sixth | 19 out |
| Saturday, August 7 |
| » Defeated Phillies (61-46), 3-2 | Wrigley Field (27-32) | 45-66 | Won 3 |
| » W: Dickie Noles (8-9) L: Larry Christenson (7-6) S: Lee Smith (5) | Sixth | 18 out |
| Sunday, August 8 |
| » Defeated Phillies (61-47), 8-5 | Wrigley Field (28-32) | 46-66 | Won 4 |
| » W: Dick Tidrow (5-2) L: Tug McGraw (1-2) S: Lee Smith (6) | Sixth | 17 out |
| Monday, August 9 |
| » Defeated Expos (57-52), 9-2 | Stade Olympique (1-3) | 47-66 | Won 5 |
| » W: Fergie Jenkins (7-13) L: Scott Sanderson (6-11) | Sixth | 17 out |
| Tuesday, August 10 |
| » Defeated Expos (57-53), 5-3 | Stade Olympique (2-3) | 48-66 | Won 6 |
| » W: Randy Martz (6-7) L: Steve Rogers (14-5) S: Dick Tidrow (3) | Sixth | 16½ out |
| Wednesday, August 11 |
| » Lost to Expos (58-53), 3-0 | Stade Olympique (2-4) | 48-67 | |
| » W: Charlie Lea (9-6) L: Allen Ripley (4-5) S: Jeff Reardon (17) | Sixth | 17½ out |
| Thursday, August 12 |
| » Defeated Mets (48-64), 13-6 | Shea Stadium (1-2) | 49-67 | |
| » W: Mike Proly (2-1) L: Jesse Orosco (1-7) S: Dick Tidrow (4) | Sixth | 16½ out |
| Friday, August 13 |
| » Lost to Mets (49-64), 6-4 | Shea Stadium (1-3) | 49-68 | |
| » W: Jesse Orosco (2-7) L: Mike Proly (2-2) | Sixth | 16½ out |
| Saturday, August 14 |
| » Defeated Mets (49-65), 7-4 | Shea Stadium (2-3) | 50-68 | |
| » W: Mike Proly (3-2) L: Pete Falcone (6-8) S: Lee Smith (7) | Sixth | 16½ out |
| Sunday, August 15 |
| » Lost to Mets (50-65), 5-4 | Shea Stadium (2-4) | 50-69 | |
| » W: Ed Lynch (2-4) L: Randy Martz (6-8) S: Pat Zachry (1) | Sixth | 17½ out |
| » Defeated Mets (50-66), 6-5 | Shea Stadium (3-4) | 51-69 | |
| » W: Mike Proly (4-2) L: Jesse Orosco (2-8) S: Lee Smith (8) | Sixth | 17½ out |
| Wednesday, August 18 |
| » Lost to Dodgers (67-53), 2-1 | Wrigley Field (28-33) | 51-70 | |
| » W: Jerry Reuss (11-9) L: Allen Ripley (4-6) | Sixth | 19½ out |
| » Lost to Dodgers (68-53), 7-4 | Wrigley Field (28-34) | 51-71 | Lost 2 |
| » W: Jerry Reuss (12-9) L: Doug Bird (7-11) S: Tom Niedenfuer (7) | Sixth | 19½ out |
| Thursday, August 19 |
| » Defeated Dodgers (68-54), 8-2 | Wrigley Field (29-34) | 52-71 | |
| » W: Fergie Jenkins (8-13) L: Bob Welch (14-8) | Fifth | 18½ out |
| Friday, August 20 |
| » Defeated Padres (64-58), 3-2 | Wrigley Field (30-34) | 53-71 | Won 2 |
| » W: Randy Martz (7-8) L: John Montefusco (9-8) S: Willie Hernandez (9) | Fifth | 17½ out |
| Saturday, August 21 |
| » Lost to Padres (65-58), 2-0 | Wrigley Field (30-35) | 53-72 | |
| » W: Tim Lollar (12-7) L: Allen Ripley (4-7) S: Luis DeLeon (12) | Fifth | 18½ out |
| Sunday, August 22 |
| » Defeated Padres (65-59), 8-7 | Wrigley Field (31-35) | 54-72 | |
| » W: Dick Tidrow (6-2) L: Gary Lucas (0-10) S: Lee Smith (9) | Fifth | 18½ out |
| Monday, August 23 |
| » Defeated Giants (64-62), 8-5 | Wrigley Field (32-35) | 55-72 | Won 2 |
| » W: Doug Bird (8-11) L: Renie Martin (5-7) S: Dick Tidrow (5) | Fifth | 18½ out |
| Tuesday, August 24 |
| » Defeated Giants (64-63), 8-4 | Wrigley Field (33-35) | 56-72 | Won 3 |
| » W: Fergie Jenkins (9-13) L: Rich Gale (5-13) | Fifth | 17½ out |
| Wednesday, August 25 |
| » Defeated Giants (64-64), 4-2 | Wrigley Field (34-35) | 57-72 | Won 4 |
| » W: Randy Martz (8-8) L: Jim Barr (3-3) S: Lee Smith (10) | Fifth | 16½ out |
| Friday, August 27 |
| » Lost to Dodgers (72-57), 9-4 | Dodger Stadium (1-3) | 57-73 | |
| » W: Ricky Wright (2-0) L: Mike Proly (4-3) S: Tom Niedenfuer (8) | Fourth | 17½ out |
| Saturday, August 28 |
| » Lost to Dodgers (73-57), 7-1 | Dodger Stadium (1-4) | 57-74 | Lost 2 |
| » W: Jerry Reuss (13-10) L: Dickie Noles (8-10) | Fourth | 18 out |
| Sunday, August 29 |
| » Defeated Dodgers (73-58), 7-2 | Dodger Stadium (2-4) | 58-74 | |
| » W: Fergie Jenkins (10-13) L: Bob Welch (15-9) | Fourth | 17½ out |
| Tuesday, August 31 |
| » Lost to Giants (66-66), 4-3 | Candlestick Park (2-3) | 58-75 | |
| » W: Al Holland (4-3) L: Willie Hernandez (4-6) S: Greg Minton (24) | Fourth | 18 out |
| Wednesday, September 1 |
| » Defeated Giants (66-67), 7-6 | Candlestick Park (3-3) | 59-75 | |
| » W: Bill Campbell (3-4) L: Rich Gale (5-14) S: Lee Smith (11) | Fifth | 18 out |
| Friday, September 3 |
| » Lost to Padres (70-65), 3-0 | San Diego/Jack Murphy Stadium (1-3) | 59-76 | |
| » W: Eric Show (10-4) L: Dickie Noles (8-11) | Fourth | 18 out |
| Saturday, September 4 |
| » Lost to Padres (71-65), 4-1 | San Diego/Jack Murphy Stadium (1-4) | 59-77 | Lost 2 |
| » W: Tim Lollar (13-8) L: Fergie Jenkins (10-14) | Fourth | 18 out |
| Sunday, September 5 |
| » Defeated Padres (71-66), 5-1 | San Diego/Jack Murphy Stadium (2-4) | 60-77 | |
| » W: Randy Martz (9-8) L: Dave Dravecky (4-2) | Fifth | 17 out |
| Monday, September 6 |
| » Defeated Phillies (76-61), 4-3 | Wrigley Field (35-35) | 61-77 | Won 2 |
| » W: Doug Bird (9-11) L: Mike Krukow (12-9) S: Lee Smith (12) | Fourth | 17 out |
| Tuesday, September 7 |
| » Lost to Phillies (77-61), 7-5 | Wrigley Field (35-36) | 61-78 | |
| » W: Tug McGraw (3-3) L: Bill Campbell (3-5) | Fourth | 17 out |
| Wednesday, September 8 |
| » Lost to Phillies (78-61), 4-3 | Wrigley Field (35-37) | 61-79 | Lost 2 |
| » W: Steve Carlton (19-9) L: Dick Tidrow (6-3) S: Ron Reed (11) | Fourth | 18 out |
| Friday, September 10 |
| » Lost to Expos (75-65), 7-2 | Wrigley Field (35-38) | 61-80 | Lost 3 |
| » W: Steve Rogers (17-7) L: Fergie Jenkins (10-15) S: Jeff Reardon (24) | Fifth | 18½ out |
| Saturday, September 11 |
| » Lost to Expos (76-65), 10-6 | Wrigley Field (35-39) | 61-81 | Lost 4 |
| » W: Scott Sanderson (10-11) L: Randy Martz (9-9) S: Woodie Fryman (11) | Fifth | 19 out |
| Sunday, September 12 |
| » Lost to Expos (77-65), 11-3 | Wrigley Field (35-40) | 61-82 | Lost 5 |
| » W: Bill Gullickson (11-11) L: Doug Bird (9-12) | Fifth | 19 out |
| Monday, September 13 |
| » Defeated Pirates (76-67), 7-3 | Three Rivers Stadium (4-3) | 62-82 | |
| » W: Allen Ripley (5-7) L: Don Robinson (15-10) S: Willie Hernandez (10) | Fifth | 18½ out |
| Tuesday, September 14 |
| » Lost to Pirates (77-67), 15-5 | Three Rivers Stadium (4-4) | 62-83 | |
| » W: Randy Niemann (1-1) L: Dickie Noles (8-12) S: Larry McWilliams (1) | Fifth | 19 out |
| Wednesday, September 15 |
| » Defeated Pirates (77-68), 7-2 | Three Rivers Stadium (5-4) | 63-83 | |
| » W: Fergie Jenkins (11-15) L: John Candelaria (12-7) | Fifth | 19 out |
| Friday, September 17 |
| » Defeated Expos (79-67), 3-1 | Stade Olympique (3-4) | 64-83 | Won 2 |
| » W: Randy Martz (10-9) L: Bill Gullickson (11-12) S: Lee Smith (13) | Fifth | 19½ out |
| Saturday, September 18 |
| » Defeated Expos (79-68), 10-7 | Stade Olympique (4-4) | 65-83 | Won 3 |
| » W: Dick Tidrow (7-3) L: Woodie Fryman (8-4) S: Lee Smith (14) | Fifth | 20 out |
| Former Cub Clyde McCullough dies in San Francisco, CA at the age of 66. |
| Sunday, September 19 |
| » Defeated Expos (79-69), 7-5 | Stade Olympique (5-4) | 66-83 | Won 4 |
| » W: Dick Tidrow (8-3) L: Bryn Smith (2-2) S: Lee Smith (15) | Fourth | 20 out |
| Monday, September 20 |
| » Defeated Pirates (79-70), 3-1 | Wrigley Field (36-40) | 67-83 | Won 5 |
| » W: Dickie Noles (9-12) L: Larry McWilliams (7-8) S: Dick Tidrow (6) | Fifth | 20 out |
| » Major-league debuts: Junior Ortiz (Pirates) |
| Tuesday, September 21 |
| » Defeated Pirates (79-71), 1-0 | Wrigley Field (37-40) | 68-83 | Won 6 |
| » W: Fergie Jenkins (12-15) L: Rod Scurry (4-5) S: Bill Campbell (7) | Fifth | 19 out |
| Wednesday, September 22 |
| » Lost to Mets (59-92), 5-2 | Wrigley Field (37-41) | 68-84 | |
| » W: Scott Holman (1-1) L: Randy Martz (10-10) S: Doug Sisk (1) | Fifth | 20 out |
| Thursday, September 23 |
| » Lost to Mets (60-92), 5-4 | Wrigley Field (37-42) | 68-85 | Lost 2 |
| » W: Ed Lynch (4-7) L: Doug Bird (9-13) S: Jesse Orosco (4) | Fifth | 20 out |
| Friday, September 24 |
| » Lost to Cardinals (89-65), 3-1 | Busch Stadium II (2-5) | 68-86 | Lost 3 |
| » W: John Stuper (9-6) L: Bill Campbell (3-6) | Fifth | 21 out |
| Saturday, September 25 |
| » Lost to Cardinals (90-65), 5-1 | Busch Stadium II (2-6) | 68-87 | Lost 4 |
| » W: Joaquin Andujar (15-10) L: Dickie Noles (9-13) | Fifth | 22 out |
| Sunday, September 26 |
| » Defeated Cardinals (90-66), 6-1 | Busch Stadium II (3-6) | 69-87 | |
| » W: Fergie Jenkins (13-15) L: Eric Rasmussen (0-2) | Fifth | 21 out |
| Monday, September 27 |
| » Defeated Phillies (84-72), 8-1 | Veteran's Stadium (2-6) | 70-87 | Won 2 |
| » W: Randy Martz (11-10) L: Marty Bystrom (5-6) | Fifth | 21 out |
| Tuesday, September 28 |
| » Lost to Phillies (85-72), 3-2 | Veteran's Stadium (2-7) | 70-88 | |
| » W: Larry Christenson (9-10) L: Doug Bird (9-14) S: Ron Reed (14) | Fifth | 21 out |
| Wednesday, September 29 |
| » Defeated Mets (64-94), 4-1 | Shea Stadium (4-4) | 71-88 | |
| » W: Mike Proly (5-3) L: Walt Terrell (0-3) S: Lee Smith (16) | Fifth | 20 out |
| » Major-league debuts: Ronn Reynolds (Mets) |
| Thursday, September 30 |
| » Defeated Mets (64-95), 3-1 | Shea Stadium (5-4) | 72-88 | Won 2 |
| » W: Dickie Noles (10-13) L: Tom Gorman (1-1) S: Lee Smith (17) | Fifth | 19 out |
| Saturday, October 2 |
| » Defeated Cardinals (91-70), 8-4 | Wrigley Field (38-42) | 73-88 | Won 3 |
| » W: Fergie Jenkins (14-15) L: Jim Kaat (5-3) S: Bill Campbell (8) | Fifth | 18 out |
| Sunday, October 3 |
| » Lost to Cardinals (92-70), 5-4 | Wrigley Field (38-43) | 73-89 | |
| » W: Eric Rasmussen (1-2) L: Ken Kravec (1-1) | Fifth | 19 out |
| Sunday, October 31 |
| Former Cub Sheriff Blake dies in Beckley, WV at the age of 84. |
Game information provided by Retrosheet (www.retrosheet.org) |