| Friday, April 9 |
| » Lost to Brewers (1-0), 15-4 | Exhibition Stadium (0-1) | 0-1 | |
| » W: Pete Vuckovich (1-0) L: Mark Bomback (0-1) | Third | 1 out |
| » Major-league debuts: Jim Gott (Blue Jays) Kevin Bass and Doug Jones (Brewers) |
| Saturday, April 10 |
| » Defeated Brewers (1-1), 3-2 | Exhibition Stadium (1-1) | 1-1 | |
| » W: Roy Lee Jackson (1-0) L: Rollie Fingers (0-1) | Third | ½ out |
| Sunday, April 11 |
| » Lost to Brewers (2-1), 14-5 | Exhibition Stadium (1-2) | 1-2 | |
| » W: Bob McClure (1-0) L: Jim Clancy (0-1) | Fourth | 1 out |
| Monday, April 12 |
| » Defeated Tigers (1-3), 9-5 | Exhibition Stadium (2-2) | 2-2 | |
| » W: Luis Leal (1-0) L: Milt Wilcox (0-1) | Third | ½ out |
| Tuesday, April 13 |
| » Lost to Tigers (2-3), 4-2 | Exhibition Stadium (2-3) | 2-3 | |
| » W: Jack Morris (1-1) L: Dale Murray (0-1) | Third | 1½ out |
| Wednesday, April 14 |
| » Defeated Tigers (2-4), 5-4 | Exhibition Stadium (3-3) | 3-3 | |
| » W: Roy Lee Jackson (2-0) L: Kevin Saucier (0-1) | Third | ½ out |
| » Major-league debuts: Howard Johnson (Tigers) |
| Thursday, April 15 |
| » Lost to Tigers (3-4), 4-2 | Tiger Stadium (0-1) | 3-4 | |
| » W: Kevin Saucier (1-1) L: Dave Stieb (0-1) S: Elias Sosa (1) | Third | 1 out |
| » Major-league debuts: Glenn Wilson (Tigers) |
| Friday, April 16 |
| » Defeated Red Sox (2-5), 2-0 | Fenway Park (1-0) | 4-4 | |
| » W: Luis Leal (2-0) L: Dennis Eckersley (1-1) S: Roy Lee Jackson (1) | Second | 1 out |
| Saturday, April 17 |
| » Lost to Red Sox (3-5), 5-4 | Fenway Park (1-1) | 4-5 | |
| » W: John Tudor (2-0) L: Mark Bomback (0-2) S: Mark Clear (1) | First | -- |
| Sunday, April 18 |
| » Lost to Red Sox (4-5), 4-3 | Fenway Park (1-2) | 4-6 | Lost 2 |
| » W: Luis Aponte (1-0) L: Roy Lee Jackson (2-1) | Fourth | 1 out |
| Monday, April 19 |
| » Defeated Red Sox (4-6), 5-4 | Fenway Park (2-2) | 5-6 | |
| » W: Dale Murray (1-1) L: Mark Clear (0-1) | Third | 1 out |
| Wednesday, April 21 |
| » Lost to Brewers (4-6), 3-1 | County Stadium (0-1) | 5-7 | |
| » W: Randy Lerch (1-0) L: Luis Leal (2-1) S: Rollie Fingers (1) | Fourth | 2½ out |
| Thursday, April 22 |
| » Lost to Brewers (5-6), 7-0 | County Stadium (0-2) | 5-8 | Lost 2 |
| » W: Mike Caldwell (1-1) L: Mark Bomback (0-3) | Fifth | 3½ out |
| Friday, April 23 |
| » Lost to Red Sox (7-6), 5-4 | Exhibition Stadium (3-4) | 5-9 | Lost 3 |
| » W: John Tudor (3-0) L: Jim Clancy (0-2) S: Mark Clear (3) | Fifth | 4½ out |
| Saturday, April 24 |
| » Lost to Red Sox (8-6), 8-7 | Exhibition Stadium (3-5) | 5-10 | Lost 4 |
| » W: Mike Torrez (1-1) L: Dave Stieb (0-2) S: Luis Aponte (2) | Sixth | 5½ out |
| Sunday, April 25 |
| » Lost to Red Sox (9-6), 5-4 | Exhibition Stadium (3-6) | 5-11 | Lost 5 |
| » W: Mark Clear (1-1) L: Joey McLaughlin (0-1) | Fifth | 5½ out |
| Tuesday, April 27 |
| » Defeated Rangers (6-9), 8-4 | Exhibition Stadium (4-6) | 6-11 | |
| » W: Dale Murray (2-1) L: Doc Medich (1-2) | Fourth | 5½ out |
| Wednesday, April 28 |
| » Defeated Rangers (6-10), 6-4 | Exhibition Stadium (5-6) | 7-11 | Won 2 |
| » W: Jim Clancy (1-2) L: Frank Tanana (1-3) S: Joey McLaughlin (1) | Fourth | 4½ out |
| Thursday, April 29 |
| » Defeated Royals (10-8), 7-0 | Royals Stadium (1-0) | 8-11 | Won 3 |
| » W: Dave Stieb (1-2) L: Paul Splittorff (1-1) | Fifth | 4 out |
| Friday, April 30 |
| » Lost to Royals (11-8), 8-7 | Royals Stadium (1-1) | 8-12 | |
| » W: Grant Jackson (2-0) L: Roy Lee Jackson (2-2) S: Dan Quisenberry (6) | Fifth | 5 out |
| Saturday, May 1 |
| » Lost to Royals (12-8), 8-7 | Royals Stadium (1-2) | 8-13 | Lost 2 |
| » W: Grant Jackson (3-0) L: Mark Bomback (0-4) S: Dan Quisenberry (7) | Fifth | 6 out |
| Sunday, May 2 |
| » Defeated Royals (12-9), 7-5 | Royals Stadium (2-2) | 9-13 | |
| » W: Jim Clancy (2-2) L: Dennis Leonard (2-2) S: Roy Lee Jackson (2) | Fifth | 6 out |
| Tuesday, May 4 |
| » Lost to White Sox (13-9), 4-3 | Comiskey Park I (0-1) | 9-14 | |
| » W: Britt Burns (3-1) L: Dave Stieb (1-3) S: Salome Barojas (7) | Fifth | 7½ out |
| Wednesday, May 5 |
| » Lost to White Sox (14-9), 4-1 | Comiskey Park I (0-2) | 9-15 | Lost 2 |
| » W: Steve Trout (2-2) L: Luis Leal (2-2) S: Dennis Lamp (1) | Fifth | 7½ out |
| Friday, May 7 |
| » Defeated Royals (14-11), 6-4 | Exhibition Stadium (6-6) | 10-15 | |
| » W: Joey McLaughlin (1-1) L: Dennis Leonard (2-3) | Fifth | 7 out |
| Saturday, May 8 |
| » Defeated Royals (14-12), 2-1 | Exhibition Stadium (7-6) | 11-15 | Won 2 |
| » W: Mark Bomback (1-4) L: Dave Frost (3-2) S: Roy Lee Jackson (3) | Fifth | 7 out |
| Sunday, May 9 |
| » Defeated Royals (14-13), 2-0 | Exhibition Stadium (8-6) | 12-15 | Won 3 |
| » W: Dave Stieb (2-3) L: Paul Splittorff (2-2) | Fifth | 7 out |
| Monday, May 10 |
| » Lost to White Sox (18-9), 6-3 | Exhibition Stadium (8-7) | 12-16 | |
| » W: Britt Burns (4-1) L: Joey McLaughlin (1-2) S: Kevin Hickey (1) | Fifth | 8 out |
| Tuesday, May 11 |
| » Defeated White Sox (18-10), 9-4 | Exhibition Stadium (9-7) | 13-16 | |
| » W: Jim Clancy (3-2) L: Steve Trout (2-3) | Fifth | 7 out |
| Wednesday, May 12 |
| » Lost to White Sox (19-10), 9-2 | Exhibition Stadium (9-8) | 13-17 | |
| » W: Dennis Lamp (3-0) L: Mark Bomback (1-5) | Sixth | 8 out |
| Thursday, May 13 |
| » Lost to Rangers (8-19), 4-3 | Arlington Stadium (0-1) | 13-18 | Lost 2 |
| » W: Danny Darwin (3-1) L: Dave Stieb (2-4) | Fifth | 8 out |
| Friday, May 14 |
| » Lost to Rangers (9-19), 4-3 | Arlington Stadium (0-2) | 13-19 | Lost 3 |
| » W: Paul Mirabella (1-0) L: Roy Lee Jackson (2-3) | Seventh | 8½ out |
| Saturday, May 15 |
| » Defeated Rangers (9-20), 5-2 | Arlington Stadium (1-2) | 14-19 | |
| » W: Jim Clancy (4-2) L: Frank Tanana (1-5) | Sixth | 8½ out |
| Sunday, May 16 |
| » Lost to Rangers (10-20), 2-1 | Arlington Stadium (1-3) | 14-20 | |
| » W: Danny Darwin (4-1) L: Roy Lee Jackson (2-4) | Sixth | 8½ out |
| Tuesday, May 18 |
| » Lost to Indians (15-19), 6-5 | Cleveland Stadium (0-1) | 14-21 | Lost 2 |
| » W: Dan Spillner (1-3) L: Dale Murray (2-2) | Seventh | 8½ out |
| Wednesday, May 19 |
| » Defeated Indians (15-20), 8-5 | Cleveland Stadium (1-1) | 15-21 | |
| » W: Jerry Garvin (1-0) L: Len Barker (4-2) S: Joey McLaughlin (2) | Sixth | 8½ out |
| Thursday, May 20 |
| » Defeated Indians (15-21), 2-0 | Cleveland Stadium (2-1) | 16-21 | Won 2 |
| » W: Jim Clancy (5-2) L: Lary Sorensen (3-3) | Sixth | 8½ out |
| Friday, May 21 |
| » Lost to Orioles (17-20), 3-0 | Exhibition Stadium (9-9) | 16-22 | |
| » W: Mike Flanagan (2-4) L: Jim Gott (0-1) S: Tippy Martinez (3) | Sixth | 9½ out |
| Saturday, May 22 |
| » Lost to Orioles (18-20), 6-0 | Exhibition Stadium (9-10) | 16-23 | Lost 2 |
| » W: Dennis Martinez (4-3) L: Dave Stieb (2-5) | Sixth | 10½ out |
| Sunday, May 23 |
| » Defeated Orioles (18-21), 7-1 | Exhibition Stadium (10-10) | 17-23 | |
| » W: Luis Leal (3-2) L: Sammy Stewart (4-3) | Fifth | 10½ out |
| Monday, May 24 |
| » Lost to Orioles (19-21), 7-5 | Exhibition Stadium (10-11) | 17-24 | |
| » W: Scott McGregor (6-3) L: Jim Clancy (5-3) S: Tim Stoddard (3) | Sixth | 11 out |
| Tuesday, May 25 |
| » Lost to Yankees (21-19), 8-0 | Yankee Stadium (0-1) | 17-25 | Lost 2 |
| » W: Tommy John (4-4) L: Jim Gott (0-2) | Seventh | 11 out |
| Wednesday, May 26 |
| » Defeated Yankees (21-20), 7-0 | Yankee Stadium (1-1) | 18-25 | |
| » W: Dave Stieb (3-5) L: Rudy May (1-3) | Seventh | 10½ out |
| Saturday, May 29 |
| » Lost to Orioles (22-22), 3-1 | Memorial Stadium (0-1) | 18-26 | |
| » W: Mike Flanagan (3-4) L: Luis Leal (3-3) | Sixth | 10 out |
| » Defeated Orioles (22-23), 11-10 | Memorial Stadium (1-1) | 19-26 | |
| » W: Joey McLaughlin (2-2) L: Tim Stoddard (0-2) | Sixth | 10 out |
| Sunday, May 30 |
| » Defeated Orioles (22-24), 6-0 | Memorial Stadium (2-1) | 20-26 | Won 2 |
| » W: Jim Gott (1-2) L: Jim Palmer (2-3) S: Roy Lee Jackson (4) | Sixth | 9 out |
| Monday, May 31 |
| » Defeated Yankees (24-21), 5-4 | Exhibition Stadium (11-11) | 21-26 | Won 3 |
| » W: Dave Stieb (4-5) L: Roger Erickson (4-5) | Seventh | 9 out |
| Tuesday, June 1 |
| » Defeated Yankees (24-22), 5-2 | Exhibition Stadium (12-11) | 22-26 | Won 4 |
| » W: Dale Murray (3-2) L: Shane Rawley (3-2) | Sixth | 8½ out |
| Wednesday, June 2 |
| » Lost to Yankees (25-22), 12-6 | Exhibition Stadium (12-12) | 22-27 | |
| » W: Shane Rawley (4-2) L: Joey McLaughlin (2-3) | Seventh | 9½ out |
| Thursday, June 3 |
| » Defeated Yankees (25-23), 3-1 | Exhibition Stadium (13-12) | 23-27 | |
| » W: Luis Leal (4-3) L: Tommy John (4-5) | Sixth | 9 out |
| Friday, June 4 |
| » Lost to Indians (26-23), 6-3 | Exhibition Stadium (13-13) | 23-28 | |
| » W: Len Barker (7-2) L: Dale Murray (3-3) S: Dan Spillner (6) | Sixth | 9 out |
| Sunday, June 6 |
| » Defeated Indians (26-24), 5-1 | Exhibition Stadium (14-13) | 24-28 | |
| » W: Dave Stieb (5-5) L: Lary Sorensen (5-4) | Sixth | 9½ out |
| » Lost to Indians (27-24), 7-5 | Exhibition Stadium (14-14) | 24-29 | |
| » W: Ed Glynn (2-0) L: Jerry Garvin (1-1) S: Dan Spillner (7) | Sixth | 9½ out |
| Monday, June 7 |
| » Defeated Indians (27-25), 7-3 | Exhibition Stadium (15-14) | 25-29 | |
| » W: Luis Leal (5-3) L: John Denny (3-6) | Sixth | 9 out |
| Tuesday, June 8 |
| » Lost to Angels (32-23), 11-4 | Exhibition Stadium (15-15) | 25-30 | |
| » W: Geoff Zahn (6-2) L: Jim Gott (1-3) | Fifth | 10 out |
| » Major-league debuts: Tom Filer (Blue Jays) |
| Wednesday, June 9 |
| » Defeated Angels (32-24), 5-4 | Exhibition Stadium (16-15) | 26-30 | |
| » W: Joey McLaughlin (3-3) L: Doug Corbett (1-6) | Sixth | 10 out |
| Friday, June 11 |
| » Defeated Athletics (26-33), 2-1 | Exhibition Stadium (17-15) | 27-30 | Won 2 |
| » W: Jim Clancy (6-3) L: Brian Kingman (0-1) | Sixth | 9½ out |
| Saturday, June 12 |
| » Lost to Athletics (27-33), 8-1 | Exhibition Stadium (17-16) | 27-31 | |
| » W: Rick Langford (5-7) L: Dave Stieb (5-6) | Seventh | 10½ out |
| Sunday, June 13 |
| » Lost to Athletics (28-33), 7-5 | Exhibition Stadium (17-17) | 27-32 | Lost 2 |
| » W: Tom Underwood (3-4) L: Roy Lee Jackson (2-5) S: Dave Beard (4) | Seventh | 11 out |
| Monday, June 14 |
| » Lost to Athletics (29-33), 4-2 | Exhibition Stadium (17-18) | 27-33 | Lost 3 |
| » W: Matt Keough (6-7) L: Jim Gott (1-4) S: Dave Beard (5) | Seventh | 11 out |
| Tuesday, June 15 |
| » Defeated Angels (35-26), 2-0 | Anaheim Stadium (1-0) | 28-33 | |
| » W: Jim Clancy (7-3) L: Mike Witt (3-1) | Seventh | 10 out |
| Wednesday, June 16 |
| » Lost to Angels (36-26), 7-1 | Anaheim Stadium (1-1) | 28-34 | |
| » W: Steve Renko (6-1) L: Dave Stieb (5-7) | Sixth | 10 out |
| Thursday, June 17 |
| » Lost to Angels (37-26), 10-8 | Anaheim Stadium (1-2) | 28-35 | Lost 2 |
| » W: Bruce Kison (6-2) L: Luis Leal (5-4) S: Angel Moreno (1) | Seventh | 11 out |
| Friday, June 18 |
| » Defeated Athletics (29-37), 6-4 | Oakland-Alameda County Stadium (1-0) | 29-35 | |
| » W: Joey McLaughlin (4-3) L: Matt Keough (6-8) | Seventh | 10 out |
| Saturday, June 19 |
| » Defeated Athletics (29-38), 3-1 | Oakland-Alameda County Stadium (2-0) | 30-35 | Won 2 |
| » W: Joey McLaughlin (5-3) L: Bob Owchinko (1-1) | Seventh | 10 out |
| Sunday, June 20 |
| » Defeated Athletics (29-39), 3-2 | Oakland-Alameda County Stadium (3-0) | 31-35 | Won 3 |
| » W: Dave Stieb (6-7) L: Rick Langford (5-8) | Seventh | 9 out |
| Monday, June 21 |
| » Lost to Mariners (35-34), 5-4 | Kingdome (0-1) | 31-36 | |
| » W: Mike Moore (3-6) L: Luis Leal (5-5) S: Bill Caudill (10) | Seventh | 10 out |
| Tuesday, June 22 |
| » Lost to Mariners (36-34), 6-5 | Kingdome (0-2) | 31-37 | Lost 2 |
| » W: Bryan Clark (1-0) L: Roy Lee Jackson (2-6) S: Bill Caudill (11) | Seventh | 11 out |
| Wednesday, June 23 |
| » Defeated Mariners (36-35), 5-3 | Kingdome (1-2) | 32-37 | |
| » W: Joey McLaughlin (6-3) L: Mike Stanton (1-1) | Seventh | 11 out |
| Saturday, June 26 |
| » Lost to Twins (18-54), 4-3 | Exhibition Stadium (17-19) | 32-38 | |
| » W: Ron Davis (2-7) L: Dave Stieb (6-8) | Seventh | 10½ out |
| Sunday, June 27 |
| » Defeated Twins (18-55), 3-2 | Exhibition Stadium (18-19) | 33-38 | |
| » W: Joey McLaughlin (7-3) L: Terry Felton (0-8) | Seventh | 9½ out |
| Tuesday, June 29 |
| » Lost to Mariners (39-36), 4-1 | Exhibition Stadium (18-20) | 33-39 | |
| » W: Floyd Bannister (7-4) L: Jim Clancy (7-4) S: Mike Stanton (5) | Seventh | 11 out |
| Wednesday, June 30 |
| » Lost to Mariners (40-36), 10-4 | Exhibition Stadium (18-21) | 33-40 | Lost 2 |
| » W: Jim Beattie (6-4) L: Dave Stieb (6-9) | Seventh | 11 out |
| Thursday, July 1 |
| » Lost to Mariners (41-36), 4-3 | Exhibition Stadium (18-22) | 33-41 | Lost 3 |
| » W: Gaylord Perry (6-7) L: Luis Leal (5-6) S: Bill Caudill (14) | Seventh | 11 out |
| Friday, July 2 |
| » Defeated Twins (21-57), 9-4 | Hubert H. Humphrey Metrodome (1-0) | 34-41 | |
| » W: Dale Murray (4-3) L: Brad Havens (3-6) S: Joey McLaughlin (3) | Seventh | 10 out |
| Saturday, July 3 |
| » Lost to Twins (22-57), 2-1 | Hubert H. Humphrey Metrodome (1-1) | 34-42 | |
| » W: Jack O'Connor (1-2) L: Jim Clancy (7-5) | Sixth | 10 out |
| Sunday, July 4 |
| » Lost to Twins (23-57), 4-3 | Hubert H. Humphrey Metrodome (1-2) | 34-43 | Lost 2 |
| » W: Jeff Little (1-0) L: Dave Stieb (6-10) | Seventh | 11 out |
| Monday, July 5 |
| » Lost to Rangers (32-41), 3-2 | Arlington Stadium (1-4) | 34-44 | Lost 3 |
| » W: Jon Matlack (4-5) L: Luis Leal (5-7) S: Danny Darwin (4) | Seventh | 11½ out |
| Tuesday, July 6 |
| » Defeated Rangers (32-42), 4-3 | Arlington Stadium (2-4) | 35-44 | |
| » W: Dale Murray (5-3) L: Frank Tanana (4-10) | Seventh | 10½ out |
| Wednesday, July 7 |
| » Lost to Royals (47-33), 3-1 | Royals Stadium (2-3) | 35-45 | |
| » W: Larry Gura (10-4) L: Jim Clancy (7-6) | Seventh | 11½ out |
| Thursday, July 8 |
| » Defeated Royals (47-34), 5-4 | Royals Stadium (3-3) | 36-45 | |
| » W: Dave Stieb (7-10) L: Mike Armstrong (2-3) S: Joey McLaughlin (4) | Seventh | 11½ out |
| Friday, July 9 |
| » Defeated White Sox (43-37), 7-6 | Exhibition Stadium (19-22) | 37-45 | Won 2 |
| » W: Dale Murray (6-3) L: Richard Dotson (3-10) S: Joey McLaughlin (5) | Seventh | 10½ out |
| Saturday, July 10 |
| » Lost to White Sox (44-37), 6-5 | Exhibition Stadium (19-23) | 37-46 | |
| » W: Chico Escarrega (1-1) L: Jim Gott (1-5) S: Kevin Hickey (4) | Seventh | 11½ out |
| Sunday, July 11 |
| » Lost to White Sox (45-37), 16-7 | Exhibition Stadium (19-24) | 37-47 | Lost 2 |
| » W: Britt Burns (9-4) L: Jim Clancy (7-7) | Seventh | 11½ out |
| Thursday, July 15 |
| » Defeated Rangers (35-47), 5-1 | Exhibition Stadium (20-24) | 38-47 | |
| » W: Dave Stieb (8-10) L: Rick Honeycutt (4-10) | Seventh | 12 out |
| Friday, July 16 |
| » Defeated Rangers (35-48), 6-0 | Exhibition Stadium (21-24) | 39-47 | Won 2 |
| » W: Jim Clancy (8-7) L: Charlie Hough (7-8) | Seventh | 12 out |
| Saturday, July 17 |
| » Defeated Rangers (35-49), 11-3 | Exhibition Stadium (22-24) | 40-47 | Won 3 |
| » W: Roy Lee Jackson (3-6) L: John Butcher (0-1) | Seventh | 12 out |
| Sunday, July 18 |
| » Defeated Rangers (35-50), 5-4 | Exhibition Stadium (23-24) | 41-47 | Won 4 |
| » W: Joey McLaughlin (8-3) L: Danny Darwin (6-4) | Seventh | 12 out |
| Monday, July 19 |
| » Defeated Royals (48-41), 4-2 | Exhibition Stadium (24-24) | 42-47 | Won 5 |
| » W: Luis Leal (6-7) L: Bud Black (3-3) | Seventh | 11 out |
| Tuesday, July 20 |
| » Defeated Royals (48-42), 9-2 | Exhibition Stadium (25-24) | 43-47 | Won 6 |
| » W: Dave Stieb (9-10) L: Larry Gura (10-7) | Sixth | 10 out |
| Wednesday, July 21 |
| » Lost to Royals (49-42), 9-7 | Exhibition Stadium (25-25) | 43-48 | |
| » W: Vida Blue (7-7) L: Jim Clancy (8-8) S: Dan Quisenberry (23) | Seventh | 11 out |
| Thursday, July 22 |
| » Lost to White Sox (48-43), 3-2 | Comiskey Park I (0-3) | 43-49 | Lost 2 |
| » W: Britt Burns (10-4) L: Joey McLaughlin (8-4) | Seventh | 11½ out |
| Friday, July 23 |
| » Defeated White Sox (48-44), 7-1 | Comiskey Park I (1-3) | 44-49 | |
| » W: Luis Leal (7-7) L: Rich Barnes (0-2) S: Roy Lee Jackson (5) | Seventh | 10½ out |
| Saturday, July 24 |
| » Defeated White Sox (48-45), 8-1 | Comiskey Park I (2-3) | 45-49 | Won 2 |
| » W: Dave Stieb (10-10) L: Dennis Lamp (7-5) S: Dale Murray (1) | Seventh | 10½ out |
| Sunday, July 25 |
| » Lost to White Sox (49-45), 5-3 | Comiskey Park I (2-4) | 45-50 | |
| » W: La Marr Hoyt (12-9) L: Jim Clancy (8-9) | Seventh | 10½ out |
| Monday, July 26 |
| » Lost to Red Sox (56-40), 3-2 | Fenway Park (2-3) | 45-51 | Lost 2 |
| » W: Dennis Eckersley (11-8) L: Jim Gott (1-6) | Seventh | 11 out |
| Tuesday, July 27 |
| » Defeated Red Sox (56-41), 3-1 | Fenway Park (3-3) | 46-51 | |
| » W: Luis Leal (8-7) L: John Tudor (6-8) | Seventh | 10½ out |
| Wednesday, July 28 |
| » Lost to Red Sox (57-41), 9-7 | Fenway Park (3-4) | 46-52 | |
| » W: Bob Ojeda (4-5) L: Roy Lee Jackson (3-7) S: Bob Stanley (8) | Seventh | 11½ out |
| Thursday, July 29 |
| » Major-league debuts: Bryan Little (Expos) |
| Friday, July 30 |
| » Defeated Tigers (50-48), 6-5 | Exhibition Stadium (26-25) | 47-52 | |
| » W: Dale Murray (7-3) L: Bob James (0-2) | Seventh | 10½ out |
| Saturday, July 31 |
| » Defeated Tigers (50-49), 1-0 | Exhibition Stadium (27-25) | 48-52 | Won 2 |
| » W: Jim Gott (2-6) L: Dave Rucker (1-1) | Seventh | 10 out |
| Sunday, August 1 |
| » Lost to Tigers (51-49), 8-5 | Exhibition Stadium (27-26) | 48-53 | |
| » W: Jack Morris (12-11) L: Luis Leal (8-8) S: Dave Tobik (5) | Seventh | 10½ out |
| Monday, August 2 |
| » Defeated Brewers (59-44), 9-4 | Exhibition Stadium (28-26) | 49-53 | |
| » W: Dave Stieb (11-10) L: Bob McClure (8-4) | Fifth | 9½ out |
| Tuesday, August 3 |
| » Lost to Brewers (60-44), 7-4 | Exhibition Stadium (28-27) | 49-54 | |
| » W: Pete Vuckovich (12-4) L: Jim Clancy (8-10) S: Rollie Fingers (24) | Seventh | 10½ out |
| Wednesday, August 4 |
| » Lost to Brewers (61-44), 8-0 | Exhibition Stadium (28-28) | 49-55 | Lost 2 |
| » W: Mike Caldwell (9-10) L: Jim Gott (2-7) | Seventh | 11½ out |
| Thursday, August 5 |
| » Lost to Tigers (53-51), 5-2 | Tiger Stadium (0-2) | 49-56 | Lost 3 |
| » W: Jerry Ujdur (5-5) L: Luis Leal (8-9) | Seventh | 12½ out |
| » Lost to Tigers (54-51), 7-4 | Tiger Stadium (0-3) | 49-57 | Lost 4 |
| » W: Dave Rucker (2-1) L: Roy Lee Jackson (3-8) S: Dave Tobik (6) | Seventh | 12½ out |
| Friday, August 6 |
| » Lost to Tigers (55-51), 6-0 | Tiger Stadium (0-4) | 49-58 | Lost 5 |
| » W: Jack Morris (13-11) L: Dave Stieb (11-11) | Seventh | 13½ out |
| Saturday, August 7 |
| » Defeated Tigers (55-52), 7-4 | Tiger Stadium (1-4) | 50-58 | |
| » W: Jim Clancy (9-10) L: Larry Pashnick (2-4) S: Dale Murray (2) | Seventh | 12½ out |
| Sunday, August 8 |
| » Defeated Tigers (55-53), 7-4 | Tiger Stadium (2-4) | 51-58 | Won 2 |
| » W: Jim Gott (3-7) L: Pat Underwood (3-8) S: Joey McLaughlin (6) | Sixth | 12 out |
| » Defeated Tigers (55-54), 7-4 | Tiger Stadium (3-4) | 52-58 | Won 3 |
| » W: Dave Geisel (1-0) L: Dave Rucker (2-2) S: Dale Murray (3) | Sixth | 12 out |
| Monday, August 9 |
| » Defeated Red Sox (61-49), 4-2 | Exhibition Stadium (29-28) | 53-58 | Won 4 |
| » W: Ken Schrom (1-0) L: Dennis Eckersley (11-10) S: Joey McLaughlin (7) | Seventh | 12 out |
| Tuesday, August 10 |
| » Defeated Red Sox (61-50), 4-0 | Exhibition Stadium (30-28) | 54-58 | Won 5 |
| » W: Dave Stieb (12-11) L: Mike Torrez (7-7) | Seventh | 12 out |
| Wednesday, August 11 |
| » Defeated Red Sox (61-51), 4-3 | Exhibition Stadium (31-28) | 55-58 | Won 6 |
| » W: Roy Lee Jackson (4-8) L: Bob Stanley (7-5) | Seventh | 11 out |
| Thursday, August 12 |
| » Lost to Brewers (66-46), 7-1 | County Stadium (0-3) | 55-59 | |
| » W: Bob McClure (9-4) L: Jim Gott (3-8) | Seventh | 13 out |
| » Lost to Brewers (67-46), 4-3 | County Stadium (0-4) | 55-60 | Lost 2 |
| » W: Randy Lerch (8-7) L: Dale Murray (7-4) S: Rollie Fingers (27) | Seventh | 13 out |
| Friday, August 13 |
| » Lost to Brewers (68-46), 3-1 | County Stadium (0-5) | 55-61 | Lost 3 |
| » W: Pete Vuckovich (13-4) L: Luis Leal (8-10) | Seventh | 14 out |
| Saturday, August 14 |
| » Defeated Brewers (68-47), 4-2 | County Stadium (1-5) | 56-61 | |
| » W: Dave Stieb (13-11) L: Mike Caldwell (10-11) | Seventh | 13 out |
| Sunday, August 15 |
| » Defeated Brewers (68-48), 3-2 | County Stadium (2-5) | 57-61 | Won 2 |
| » W: Jim Clancy (10-10) L: Jim Slaton (9-4) S: Dale Murray (4) | Seventh | 12 out |
| Monday, August 16 |
| » Defeated Indians (55-59), 2-1 | Exhibition Stadium (32-28) | 58-61 | Won 3 |
| » W: Jim Gott (4-8) L: Rick Waits (1-12) S: Joey McLaughlin (8) | Sixth | 11½ out |
| Tuesday, August 17 |
| » Lost to Indians (56-59), 6-5 | Exhibition Stadium (32-29) | 58-62 | |
| » W: Dan Spillner (9-7) L: Joey McLaughlin (8-5) | Seventh | 12 out |
| » Lost to Indians (57-59), 9-5 | Exhibition Stadium (32-30) | 58-63 | Lost 2 |
| » W: Rick Sutcliffe (10-4) L: Dave Geisel (1-1) | Seventh | 12 out |
| Wednesday, August 18 |
| » Major-league debuts: Ron Musselman (Mariners) |
| Friday, August 20 |
| » Lost to Yankees (60-59), 4-2 | Yankee Stadium (1-2) | 58-64 | Lost 3 |
| » W: Shane Rawley (7-8) L: Dave Stieb (13-12) S: Rich Gossage (26) | Seventh | 13 out |
| Saturday, August 21 |
| » Defeated Yankees (60-60), 3-1 | Yankee Stadium (2-2) | 59-64 | |
| » W: Jim Clancy (11-10) L: Ron Guidry (11-5) S: Dale Murray (5) | Seventh | 13 out |
| Sunday, August 22 |
| » Lost to Yankees (61-60), 3-1 | Yankee Stadium (2-3) | 59-65 | |
| » W: Dave Righetti (8-5) L: Jim Gott (4-9) S: Rich Gossage (27) | Seventh | 14 out |
| Monday, August 23 |
| » Lost to Yankees (62-60), 4-3 | Yankee Stadium (2-4) | 59-66 | Lost 2 |
| » W: Dave LaRoche (4-1) L: Luis Leal (8-11) S: Rich Gossage (28) | Seventh | 14 out |
| Tuesday, August 24 |
| » Lost to Orioles (65-57), 7-3 | Memorial Stadium (2-2) | 59-67 | Lost 3 |
| » W: Dennis Martinez (12-10) L: Joey McLaughlin (8-6) | Seventh | 15 out |
| Wednesday, August 25 |
| » Lost to Orioles (66-57), 8-3 | Memorial Stadium (2-3) | 59-68 | Lost 4 |
| » W: Mike Flanagan (10-10) L: Jim Clancy (11-11) | Sixth | 15½ out |
| Thursday, August 26 |
| » Lost to Orioles (67-57), 12-5 | Memorial Stadium (2-4) | 59-69 | Lost 5 |
| » W: Storm Davis (4-3) L: Jim Gott (4-10) | Seventh | 16½ out |
| Friday, August 27 |
| » Defeated Yankees (64-62), 10-3 | Exhibition Stadium (33-30) | 60-69 | |
| » W: Luis Leal (9-11) L: Dave Righetti (8-6) | Sixth | 16½ out |
| Saturday, August 28 |
| » Defeated Yankees (64-63), 3-2 | Exhibition Stadium (34-30) | 61-69 | Won 2 |
| » W: Dale Murray (8-4) L: Dave LaRoche (4-2) | Sixth | 15½ out |
| Sunday, August 29 |
| » Lost to Yankees (65-63), 8-2 | Exhibition Stadium (34-31) | 61-70 | |
| » W: Tommy John (10-10) L: Jim Clancy (11-12) | Sixth | 16½ out |
| Monday, August 30 |
| » Lost to Orioles (71-58), 6-3 | Exhibition Stadium (34-32) | 61-71 | Lost 2 |
| » W: Storm Davis (5-3) L: Mark Eichhorn (0-1) S: Tippy Martinez (12) | Seventh | 16½ out |
| » Major-league debuts: Mark Eichhorn (Blue Jays) |
| Tuesday, August 31 |
| » Lost to Orioles (72-58), 1-0 | Exhibition Stadium (34-33) | 61-72 | Lost 3 |
| » W: Jim Palmer (12-3) L: Luis Leal (9-12) | Seventh | 17½ out |
| Wednesday, September 1 |
| » Lost to Orioles (73-58), 5-2 | Exhibition Stadium (34-34) | 61-73 | Lost 4 |
| » W: Dennis Martinez (14-10) L: Dave Stieb (13-13) | Seventh | 18½ out |
| Friday, September 3 |
| » Lost to Indians (63-68), 3-2 | Cleveland Stadium (2-2) | 61-74 | Lost 5 |
| » W: Bud Anderson (2-1) L: Jim Clancy (11-13) S: Tom Brennan (2) | Seventh | 18½ out |
| » Major-league debuts: Neal Heaton (Indians) |
| Saturday, September 4 |
| » Lost to Indians (64-68), 4-3 | Cleveland Stadium (2-3) | 61-75 | Lost 6 |
| » W: Tom Brennan (1-2) L: Dale Murray (8-5) S: Dan Spillner (17) | Sixth | 19½ out |
| » Major-league debuts: Geno Petralli (Blue Jays) |
| Sunday, September 5 |
| » Defeated Indians (64-69), 6-5 | Cleveland Stadium (3-3) | 62-75 | |
| » W: Luis Leal (10-12) L: Len Barker (12-11) S: Dale Murray (6) | Sixth | 19½ out |
| Monday, September 6 |
| » Defeated Athletics (59-79), 3-1 | Oakland-Alameda County Stadium (4-0) | 63-75 | Won 2 |
| » W: Dave Stieb (14-13) L: Brian Kingman (3-11) | Seventh | 18½ out |
| Tuesday, September 7 |
| » Defeated Athletics (59-80), 2-1 | Oakland-Alameda County Stadium (5-0) | 64-75 | Won 3 |
| » W: Jim Clancy (12-13) L: John D'Acquisto (0-1) S: Dale Murray (7) | Seventh | 18½ out |
| Wednesday, September 8 |
| » Defeated Athletics (59-81), 6-5 | Oakland-Alameda County Stadium (6-0) | 65-75 | Won 4 |
| » W: Roy Lee Jackson (5-8) L: Tim Conroy (0-1) S: Dale Murray (8) | Sixth | 18½ out |
| Friday, September 10 |
| » Lost to Angels (78-62), 6-2 | Anaheim Stadium (1-3) | 65-76 | |
| » W: Geoff Zahn (16-7) L: Luis Leal (10-13) | Seventh | 19 out |
| Saturday, September 11 |
| » Lost to Angels (79-62), 4-1 | Anaheim Stadium (1-4) | 65-77 | Lost 2 |
| » W: Ken Forsch (12-10) L: Dave Stieb (14-14) | Seventh | 19 out |
| Sunday, September 12 |
| » Lost to Angels (80-62), 3-2 | Anaheim Stadium (1-5) | 65-78 | Lost 3 |
| » W: Tommy John (12-11) L: Jim Clancy (12-14) S: John Curtis (1) | Seventh | 19 out |
| » Major-league debuts: Dave Baker (Blue Jays) |
| Wednesday, September 15 |
| » Defeated Athletics (60-84), 3-2 | Exhibition Stadium (35-34) | 66-78 | |
| » W: Luis Leal (11-13) L: Tim Conroy (0-2) S: Dale Murray (9) | Seventh | 18½ out |
| » Defeated Athletics (60-85), 12-11 | Exhibition Stadium (36-34) | 67-78 | Won 2 |
| » W: Roy Lee Jackson (6-8) L: Preston Hanna (3-3) | Seventh | 18½ out |
| Thursday, September 16 |
| » Defeated Angels (82-64), 2-1 | Exhibition Stadium (37-34) | 68-78 | Won 3 |
| » W: Roy Lee Jackson (7-8) L: Luis Sanchez (6-3) | Seventh | 18 out |
| Friday, September 17 |
| » Defeated Angels (82-65), 6-2 | Exhibition Stadium (38-34) | 69-78 | Won 4 |
| » W: Jim Clancy (13-14) L: Tommy John (12-12) S: Dale Murray (10) | Seventh | 18 out |
| Saturday, September 18 |
| » Lost to Angels (83-65), 8-6 | Exhibition Stadium (38-35) | 69-79 | |
| » W: Luis Sanchez (7-3) L: Dale Murray (8-6) | Seventh | 19 out |
| Sunday, September 19 |
| » Lost to Angels (84-65), 5-1 | Exhibition Stadium (38-36) | 69-80 | Lost 2 |
| » W: Bruce Kison (9-5) L: Mark Eichhorn (0-2) | Seventh | 20 out |
| Monday, September 20 |
| » Lost to Twins (57-93), 4-1 | Hubert H. Humphrey Metrodome (1-3) | 69-81 | Lost 3 |
| » W: Bobby Castillo (11-11) L: Luis Leal (11-14) S: Ron Davis (21) | Seventh | 21 out |
| Tuesday, September 21 |
| » Defeated Twins (57-94), 5-1 | Hubert H. Humphrey Metrodome (2-3) | 70-81 | |
| » W: Dave Stieb (15-14) L: Frank Viola (4-8) | Seventh | 20 out |
| Wednesday, September 22 |
| » Defeated Twins (57-95), 3-2 | Hubert H. Humphrey Metrodome (3-3) | 71-81 | Won 2 |
| » W: Jim Clancy (14-14) L: Brad Havens (9-13) | Seventh | 20 out |
| Friday, September 24 |
| » Lost to Mariners (74-79), 3-2 | Kingdome (1-3) | 71-82 | |
| » W: Ed Vande Berg (9-4) L: Dale Murray (8-7) | Seventh | 21 out |
| Saturday, September 25 |
| » Lost to Mariners (75-79), 7-0 | Kingdome (1-4) | 71-83 | Lost 2< |