| Tuesday, April 6 |
| » Lost to Cardinals (1-0), 14-3 | Astrodome (0-1) | 0-1 | |
| » W: Bob Forsch (1-0) L: Nolan Ryan (0-1) | Second | 1 out |
| Wednesday, April 7 |
| » Defeated Cardinals (1-1), 3-2 | Astrodome (1-1) | 1-1 | |
| » W: Joe Niekro (1-0) L: John Martin (0-1) S: Joe Sambito (1) | Second | 1 out |
| Thursday, April 8 |
| » Defeated Cardinals (1-2), 1-0 | Astrodome (2-1) | 2-1 | Won 2 |
| » W: Bob Knepper (1-0) L: Joaquin Andujar (0-1) S: Dave Smith (1) | Second | ½ out |
| Friday, April 9 |
| » Lost to Braves (3-0), 6-2 | Atlanta-Fulton County Stadium (0-1) | 2-2 | |
| » W: Tommy Boggs (1-0) L: Don Sutton (0-1) S: Al Hrabosky (1) | Third | 1½ out |
| Saturday, April 10 |
| » Lost to Braves (4-0), 8-6 | Atlanta-Fulton County Stadium (0-2) | 2-3 | Lost 2 |
| » W: Larry McWilliams (1-0) L: Vern Ruhle (0-1) S: Rick Camp (1) | Fourth | 2½ out |
| Sunday, April 11 |
| » Lost to Braves (5-0), 5-0 | Atlanta-Fulton County Stadium (0-3) | 2-4 | Lost 3 |
| » W: Rick Mahler (2-0) L: Nolan Ryan (0-2) | Fourth | 3½ out |
| Monday, April 12 |
| » Defeated Dodgers (3-2), 2-1 | Astrodome (3-1) | 3-4 | |
| » W: Mike LaCoss (1-0) L: Dave Stewart (0-1) | Third | 3½ out |
| Tuesday, April 13 |
| » Lost to Dodgers (4-2), 9-5 | Astrodome (3-2) | 3-5 | |
| » W: Bob Welch (2-0) L: Bob Knepper (1-1) | Fourth | 4½ out |
| Wednesday, April 14 |
| » Defeated Dodgers (4-3), 2-1 | Astrodome (4-2) | 4-5 | |
| » W: Don Sutton (1-1) L: Burt Hooton (0-1) S: Joe Sambito (2) | Third | 4½ out |
| Friday, April 16 |
| » Lost to Braves (9-0), 5-3 | Astrodome (4-3) | 4-6 | |
| » W: Larry McWilliams (2-0) L: Nolan Ryan (0-3) S: Rick Camp (2) | Fourth | 5½ out |
| Saturday, April 17 |
| » Lost to Braves (10-0), 2-1 | Astrodome (4-4) | 4-7 | Lost 2 |
| » W: Preston Hanna (1-0) L: Joe Niekro (1-1) S: Gene Garber (2) | Fifth | 6½ out |
| Sunday, April 18 |
| » Lost to Braves (11-0), 6-5 | Astrodome (4-5) | 4-8 | Lost 3 |
| » W: Al Hrabosky (1-0) L: Dave Smith (0-1) S: Rick Camp (3) | Fifth | 7½ out |
| Monday, April 19 |
| » Defeated Dodgers (4-8), 6-4 | Dodger Stadium (1-0) | 5-8 | |
| » W: Don Sutton (2-1) L: Terry Forster (1-2) S: Joe Sambito (3) | Fourth | 7 out |
| Tuesday, April 20 |
| » Lost to Dodgers (5-8), 10-2 | Dodger Stadium (1-1) | 5-9 | |
| » W: Fernando Valenzuela (2-1) L: Vern Ruhle (0-2) | Fifth | 8 out |
| Wednesday, April 21 |
| » Lost to Dodgers (6-8), 6-0 | Dodger Stadium (1-2) | 5-10 | Lost 2 |
| » W: Jerry Reuss (1-1) L: Nolan Ryan (0-4) | Fifth | 9 out |
| Friday, April 23 |
| » Defeated Reds (4-11), 7-3 | Astrodome (5-5) | 6-10 | |
| » W: Joe Niekro (2-1) L: Tom Seaver (0-2) | Fourth | 7½ out |
| Saturday, April 24 |
| » Lost to Reds (5-11), 3-2 | Astrodome (5-6) | 6-11 | |
| » W: Frank Pastore (2-1) L: Bob Knepper (1-2) S: Tom Hume (4) | Fourth | 7½ out |
| Sunday, April 25 |
| » Lost to Reds (6-11), 4-3 | Astrodome (5-7) | 6-12 | Lost 2 |
| » W: Bob Shirley (1-1) L: Randy Moffitt (0-1) S: Tom Hume (5) | Sixth | 8 out |
| Monday, April 26 |
| » Defeated Cardinals (13-5), 6-2 | Busch Stadium II (1-0) | 7-12 | |
| » W: Nolan Ryan (1-4) L: John Martin (2-2) | Fifth | 7 out |
| Tuesday, April 27 |
| » Defeated Cardinals (13-6), 3-0 | Busch Stadium II (2-0) | 8-12 | Won 2 |
| » W: Vern Ruhle (1-2) L: Steve Mura (2-1) S: Joe Sambito (4) | Fourth | 6 out |
| Wednesday, April 28 |
| » Lost to Cardinals (14-6), 5-4 | Busch Stadium II (2-1) | 8-13 | |
| » W: Bob Forsch (4-0) L: Dave Smith (0-2) S: Bruce Sutter (7) | Fifth | 7 out |
| Thursday, April 29 |
| » Lost to Pirates (8-9), 9-6 | Three Rivers Stadium (0-1) | 8-14 | Lost 2 |
| » W: Enrique Romo (2-1) L: Mike LaCoss (1-1) S: Rod Scurry (2) | Sixth | 8 out |
| Friday, April 30 |
| » Defeated Pirates (8-10), 4-3 | Three Rivers Stadium (1-1) | 9-14 | |
| » W: Don Sutton (3-1) L: Rick Rhoden (0-3) S: Dave Smith (2) | Sixth | 8 out |
| Saturday, May 1 |
| » Defeated Pirates (8-11), 6-3 | Three Rivers Stadium (2-1) | 10-14 | Won 2 |
| » W: Nolan Ryan (2-4) L: Paul Moskau (0-1) S: Dave Smith (3) | Sixth | 7 out |
| » Major-league debuts: Cecilio Guante (Pirates) |
| Sunday, May 2 |
| » Defeated Pirates (8-12), 6-2 | Three Rivers Stadium (3-1) | 11-14 | Won 3 |
| » W: Joe Niekro (3-1) L: Tom Griffin (1-2) S: Randy Moffitt (1) | Fourth | 7 out |
| Tuesday, May 4 |
| » Lost to Reds (11-13), 5-2 | Riverfront Stadium (0-1) | 11-15 | |
| » W: Tom Seaver (1-3) L: Bob Knepper (1-3) S: Tom Hume (6) | Sixth | 7½ out |
| Wednesday, May 5 |
| » Defeated Reds (11-14), 8-7 | Riverfront Stadium (1-1) | 12-15 | |
| » W: Don Sutton (4-1) L: Frank Pastore (3-2) S: Dave Smith (4) | Fourth | 6½ out |
| Friday, May 7 |
| » Lost to Cubs (9-18), 12-6 | Wrigley Field (0-1) | 12-16 | |
| » W: Randy Martz (3-2) L: Nolan Ryan (2-5) | Sixth | 7½ out |
| Saturday, May 8 |
| » Lost to Cubs (10-18), 3-2 | Wrigley Field (0-2) | 12-17 | Lost 2 |
| » W: Dickie Noles (4-3) L: Joe Niekro (3-2) S: Bill Campbell (2) | Sixth | 7½ out |
| Sunday, May 9 |
| » Lost to Cubs (11-18), 6-3 | Wrigley Field (0-3) | 12-18 | Lost 3 |
| » W: Willie Hernandez (1-2) L: Randy Moffitt (0-2) | Sixth | 8½ out |
| Monday, May 10 |
| » Defeated Pirates (12-15), 7-3 | Astrodome (6-7) | 13-18 | |
| » W: Don Sutton (5-1) L: Rick Rhoden (1-4) | Sixth | 8 out |
| Tuesday, May 11 |
| » Defeated Pirates (12-16), 4-2 | Astrodome (7-7) | 14-18 | Won 2 |
| » W: Nolan Ryan (3-5) L: Tom Griffin (1-3) S: Dave Smith (5) | Fifth | 7 out |
| Thursday, May 13 |
| » Lost to Cubs (13-19), 5-0 | Astrodome (7-8) | 14-19 | |
| » W: Allen Ripley (1-0) L: Joe Niekro (3-3) S: Lee Smith (2) | Sixth | 7½ out |
| Friday, May 14 |
| » Lost to Cubs (14-19), 6-3 | Astrodome (7-9) | 14-20 | Lost 2 |
| » W: Dickie Noles (5-3) L: Bob Knepper (1-4) S: Willie Hernandez (3) | Sixth | 8½ out |
| Saturday, May 15 |
| » Defeated Cubs (14-20), 4-1 | Astrodome (8-9) | 15-20 | |
| » W: Don Sutton (6-1) L: Fergie Jenkins (2-4) | Fourth | 7½ out |
| Sunday, May 16 |
| » Lost to Cubs (15-20), 2-1 | Astrodome (8-10) | 15-21 | |
| » W: Doug Bird (3-4) L: Nolan Ryan (3-6) S: Willie Hernandez (4) | Fifth | 8½ out |
| Monday, May 17 |
| » Defeated Phillies (19-16), 8-1 | Veteran's Stadium (1-0) | 16-21 | |
| » W: Vern Ruhle (2-2) L: Ron Reed (1-1) | Fifth | 7½ out |
| Tuesday, May 18 |
| » Defeated Phillies (19-17), 2-1 | Veteran's Stadium (2-0) | 17-21 | Won 2 |
| » W: Dave Smith (1-2) L: Ed Farmer (1-2) | Fourth | 7½ out |
| Wednesday, May 19 |
| » Defeated Phillies (19-18), 5-3 | Veteran's Stadium (3-0) | 18-21 | Won 3 |
| » W: Bob Knepper (2-4) L: Steve Carlton (4-6) S: Dave Smith (6) | Fourth | 7½ out |
| Friday, May 21 |
| » Defeated Mets (21-18), 5-1 | Astrodome (9-10) | 19-21 | Won 4 |
| » W: Don Sutton (7-1) L: Mike Scott (3-3) | Third | 7½ out |
| Saturday, May 22 |
| » Lost to Mets (22-18), 6-5 | Astrodome (9-11) | 19-22 | |
| » W: Neil Allen (1-2) L: Randy Moffitt (0-3) | Fourth | 7½ out |
| Sunday, May 23 |
| » Lost to Mets (23-18), 2-0 | Astrodome (9-12) | 19-23 | Lost 2 |
| » W: Randy Jones (6-2) L: Joe Niekro (3-4) | Fourth | 7½ out |
| Monday, May 24 |
| » Lost to Expos (20-19), 2-0 | Astrodome (9-13) | 19-24 | Lost 3 |
| » W: Bill Gullickson (3-3) L: Bob Knepper (2-5) S: Woodie Fryman (4) | Fourth | 7½ out |
| Tuesday, May 25 |
| » Lost to Expos (21-19), 6-1 | Astrodome (9-14) | 19-25 | Lost 4 |
| » W: David Palmer (1-0) L: Vern Ruhle (2-3) S: Bryn Smith (1) | Fourth | 8½ out |
| Wednesday, May 26 |
| » Lost to Expos (22-19), 4-0 | Astrodome (9-15) | 19-26 | Lost 5 |
| » W: Charlie Lea (3-2) L: Frank LaCorte (0-1) | Fourth | 8½ out |
| Friday, May 28 |
| » Defeated Mets (25-20), 8-3 | Shea Stadium (1-0) | 20-26 | |
| » W: Nolan Ryan (4-6) L: Randy Jones (6-3) S: Dave Smith (7) | Fourth | 8 out |
| Saturday, May 29 |
| » Defeated Mets (25-21), 5-2 | Shea Stadium (2-0) | 21-26 | Won 2 |
| » W: Joe Niekro (4-4) L: Pat Zachry (4-2) | Fourth | 7 out |
| Sunday, May 30 |
| » Lost to Mets (26-21), 9-5 | Shea Stadium (2-1) | 21-27 | |
| » W: Mike Scott (4-4) L: Bob Knepper (2-6) S: Neil Allen (13) | Fourth | 7 out |
| Monday, May 31 |
| » Lost to Expos (25-20), 10-0 | Stade Olympique (0-1) | 21-28 | Lost 2 |
| » W: Charlie Lea (4-2) L: Don Sutton (7-2) | Fourth | 7 out |
| Wednesday, June 2 |
| » Defeated Expos (25-21), 6-4 | Stade Olympique (1-1) | 22-28 | |
| » W: Nolan Ryan (5-6) L: Scott Sanderson (5-4) | Fourth | 7½ out |
| Friday, June 4 |
| » Defeated Phillies (26-23), 8-3 | Astrodome (10-15) | 23-28 | Won 2 |
| » W: Vern Ruhle (3-3) L: Ed Farmer (1-4) | Fourth | 7 out |
| Saturday, June 5 |
| » Lost to Phillies (27-23), 5-3 | Astrodome (10-16) | 23-29 | |
| » W: Sparky Lyle (2-1) L: Dave Smith (1-3) | Fifth | 8 out |
| Sunday, June 6 |
| » Defeated Phillies (27-24), 7-6 | Astrodome (11-16) | 24-29 | |
| » W: Vern Ruhle (4-3) L: Warren Brusstar (2-2) | Fifth | 7 out |
| Tuesday, June 8 |
| » Lost to Giants (26-30), 7-3 | Candlestick Park (0-1) | 24-30 | |
| » W: Atlee Hammaker (3-3) L: Nolan Ryan (5-7) S: Gary Lavelle (3) | Fifth | 8½ out |
| Wednesday, June 9 |
| » Defeated Giants (26-31), 6-1 | Candlestick Park (1-1) | 25-30 | |
| » W: Joe Niekro (5-4) L: Bill Laskey (4-4) | Fifth | 8½ out |
| Thursday, June 10 |
| » Lost to Padres (31-23), 5-0 | San Diego/Jack Murphy Stadium (0-1) | 25-31 | |
| » W: John Curtis (5-3) L: Bob Knepper (2-7) | Fifth | 9 out |
| Friday, June 11 |
| » Lost to Padres (32-23), 6-2 | San Diego/Jack Murphy Stadium (0-2) | 25-32 | Lost 2 |
| » W: Tim Lollar (6-1) L: Don Sutton (7-3) | Fifth | 10 out |
| Saturday, June 12 |
| » Lost to Padres (33-23), 4-0 | San Diego/Jack Murphy Stadium (0-3) | 25-33 | Lost 3 |
| » W: Chris Welsh (5-1) L: Vern Ruhle (4-4) | Fifth | 11 out |
| Sunday, June 13 |
| » Lost to Padres (34-23), 5-4 | San Diego/Jack Murphy Stadium (0-4) | 25-34 | Lost 4 |
| » W: John Montefusco (5-4) L: Nolan Ryan (5-8) S: Gary Lucas (8) | Fifth | 11½ out |
| Monday, June 14 |
| » Defeated Braves (36-23), 9-0 | Astrodome (12-16) | 26-34 | |
| » W: Joe Niekro (6-4) L: Rick Mahler (6-5) | Fifth | 10½ out |
| Tuesday, June 15 |
| » Lost to Braves (37-23), 7-0 | Astrodome (12-17) | 26-35 | |
| » W: Bob Walk (6-4) L: Bob Knepper (2-8) | Fifth | 11½ out |
| Wednesday, June 16 |
| » Lost to Braves (38-23), 5-4 | Astrodome (12-18) | 26-36 | Lost 2 |
| » W: Gene Garber (5-2) L: George Cappuzzello (0-1) | Sixth | 12½ out |
| Friday, June 18 |
| » Defeated Padres (34-27), 7-2 | Astrodome (13-18) | 27-36 | |
| » W: Nolan Ryan (6-8) L: Chris Welsh (5-2) | Fifth | 12½ out |
| Saturday, June 19 |
| » Lost to Padres (35-27), 7-1 | Astrodome (13-19) | 27-37 | |
| » W: John Montefusco (6-4) L: Joe Niekro (6-5) S: Gary Lucas (9) | Fifth | 12½ out |
| Sunday, June 20 |
| » Defeated Padres (35-28), 8-4 | Astrodome (14-19) | 28-37 | |
| » W: Mike LaCoss (2-1) L: Juan Eichelberger (5-8) | Fifth | 11½ out |
| Monday, June 21 |
| » Lost to Padres (36-28), 7-4 | Astrodome (14-20) | 28-38 | |
| » W: Eric Show (4-2) L: Mike LaCoss (2-2) | Fifth | 12½ out |
| Tuesday, June 22 |
| » Defeated Giants (30-39), 2-0 | Astrodome (15-20) | 29-38 | |
| » W: Vern Ruhle (5-4) L: Rich Gale (2-7) | Fifth | 11½ out |
| Wednesday, June 23 |
| » Lost to Giants (31-39), 9-8 | Astrodome (15-21) | 29-39 | |
| » W: Fred Breining (4-1) L: Frank LaCorte (0-2) S: Greg Minton (12) | Sixth | 12½ out |
| Thursday, June 24 |
| » Lost to Giants (32-39), 4-3 | Astrodome (15-22) | 29-40 | Lost 2 |
| » W: Atlee Hammaker (4-4) L: Joe Niekro (6-6) | Sixth | 12½ out |
| Friday, June 25 |
| » Defeated Dodgers (37-35), 7-5 | Astrodome (16-22) | 30-40 | |
| » W: Mike LaCoss (3-2) L: Terry Forster (2-4) S: Bert Roberge (1) | Fifth | 12½ out |
| Saturday, June 26 |
| » Lost to Dodgers (38-35), 4-1 | Astrodome (16-23) | 30-41 | |
| » W: Dave Stewart (3-4) L: Don Sutton (7-4) S: Steve Howe (6) | Sixth | 12½ out |
| Sunday, June 27 |
| » Lost to Dodgers (39-35), 7-3 | Astrodome (16-24) | 30-42 | Lost 2 |
| » W: Terry Forster (3-4) L: Vern Ruhle (5-5) | Sixth | 13½ out |
| Monday, June 28 |
| » Defeated Braves (43-29), 6-2 | Atlanta-Fulton County Stadium (1-3) | 31-42 | |
| » W: Nolan Ryan (7-8) L: Rick Mahler (7-6) | Fifth | 12½ out |
| Tuesday, June 29 |
| » Lost to Braves (44-29), 6-5 | Atlanta-Fulton County Stadium (1-4) | 31-43 | |
| » W: Steve Bedrosian (4-1) L: Mike LaCoss (3-3) | Fifth | 13½ out |
| Wednesday, June 30 |
| » Lost to Braves (45-29), 5-4 | Atlanta-Fulton County Stadium (1-5) | 31-44 | Lost 2 |
| » W: Carlos Diaz (1-0) L: Bob Knepper (2-9) | Fifth | 14½ out |
| » Major-league debuts: Carlos Diaz (Braves) |
| Friday, July 2 |
| » Defeated Dodgers (41-38), 4-1 | Dodger Stadium (2-2) | 32-44 | |
| » W: Don Sutton (8-4) L: Vicente Romo (0-2) S: Frank LaCorte (1) | Fifth | 14½ out |
| Saturday, July 3 |
| » Lost to Dodgers (42-38), 5-4 | Dodger Stadium (2-3) | 32-45 | |
| » W: Fernando Valenzuela (11-6) L: Bert Roberge (0-1) | Fifth | 15½ out |
| Sunday, July 4 |
| » Defeated Dodgers (42-39), 3-0 | Dodger Stadium (3-3) | 33-45 | |
| » W: Nolan Ryan (8-8) L: Jerry Reuss (9-6) | Fifth | 15½ out |
| Monday, July 5 |
| » Defeated Pirates (40-38), 6-4 | Three Rivers Stadium (4-1) | 34-45 | Won 2 |
| » W: Joe Niekro (7-6) L: Ross Baumgarten (0-2) | Fifth | 15½ out |
| Tuesday, July 6 |
| » Lost to Pirates (41-38), 1-0 | Three Rivers Stadium (4-2) | 34-46 | |
| » W: Larry McWilliams (4-3) L: Bob Knepper (2-10) | Fifth | 15½ out |
| Wednesday, July 7 |
| » Defeated Cubs (32-52), 5-1 | Astrodome (17-24) | 35-46 | |
| » W: Don Sutton (9-4) L: Allen Ripley (3-1) | Fifth | 15½ out |
| Thursday, July 8 |
| » Lost to Cubs (33-52), 5-3 | Astrodome (17-25) | 35-47 | |
| » W: Dick Tidrow (4-1) L: Vern Ruhle (5-6) S: Willie Hernandez (8) | Fifth | 15½ out |
| Friday, July 9 |
| » Lost to Cardinals (48-37), 3-2 | Astrodome (17-26) | 35-48 | Lost 2 |
| » W: Dave LaPoint (5-2) L: Nolan Ryan (8-9) S: Jim Kaat (1) | Fifth | 16½ out |
| Saturday, July 10 |
| » Defeated Cardinals (48-38), 4-2 | Astrodome (18-26) | 36-48 | |
| » W: Joe Niekro (8-6) L: Bob Forsch (8-5) | Fifth | 15½ out |
| Sunday, July 11 |
| » Defeated Cardinals (48-39), 4-2 | Astrodome (19-26) | 37-48 | Won 2 |
| » W: Bob Knepper (3-10) L: Joaquin Andujar (7-8) | Fifth | 14½ out |
| Thursday, July 15 |
| » Lost to Pirates (45-40), 5-1 | Astrodome (19-27) | 37-49 | |
| » W: John Candelaria (5-4) L: Don Sutton (9-5) S: Rod Scurry (6) | Fifth | 15½ out |
| Friday, July 16 |
| » Defeated Pirates (45-41), 4-2 | Astrodome (20-27) | 38-49 | |
| » W: Nolan Ryan (9-9) L: Larry McWilliams (5-4) | Fifth | 14½ out |
| Saturday, July 17 |
| » Defeated Pirates (45-42), 4-3 | Astrodome (21-27) | 39-49 | Won 2 |
| » W: Joe Niekro (9-6) L: Kent Tekulve (6-4) | Fifth | 14½ out |
| Sunday, July 18 |
| » Defeated Pirates (45-43), 4-2 | Astrodome (22-27) | 40-49 | Won 3 |
| » W: Bob Knepper (4-10) L: Don Robinson (10-4) | Fifth | 14½ out |
| Monday, July 19 |
| » Lost to Cubs (38-56), 6-5 | Wrigley Field (0-4) | 40-50 | |
| » W: Lee Smith (2-5) L: Frank LaCorte (0-3) | Fifth | 15½ out |
| Tuesday, July 20 |
| » Lost to Cubs (39-56), 5-3 | Wrigley Field (0-5) | 40-51 | Lost 2 |
| » W: Willie Hernandez (3-5) L: Don Sutton (9-6) S: Dick Tidrow (2) | Fifth | 16½ out |
| Wednesday, July 21 |
| » Defeated Cubs (39-57), 2-1 | Wrigley Field (1-5) | 41-51 | |
| » W: Nolan Ryan (10-9) L: Allen Ripley (3-2) S: Frank LaCorte (2) | Fifth | 15½ out |
| Friday, July 23 |
| » Lost to Cardinals (53-42), 6-2 | Busch Stadium II (2-2) | 41-52 | |
| » W: Joaquin Andujar (8-9) L: Joe Niekro (9-7) | Fifth | 15½ out |
| Saturday, July 24 |
| » Lost to Cardinals (54-42), 5-1 | Busch Stadium II (2-3) | 41-53 | Lost 2 |
| » W: Bob Forsch (10-5) L: Bob Knepper (4-11) | Fifth | 16½ out |
| Sunday, July 25 |
| » Lost to Cardinals (55-42), 4-3 | Busch Stadium II (2-4) | 41-54 | Lost 3 |
| » W: Bruce Sutter (7-5) L: Don Sutton (9-7) | Fifth | 16½ out |
| Tuesday, July 27 |
| » Defeated Reds (37-61), 3-2 | Astrodome (23-27) | 42-54 | |
| » W: Nolan Ryan (11-9) L: Charlie Leibrandt (3-6) | Fifth | 17 out |
| Wednesday, July 28 |
| » Defeated Reds (37-62), 4-2 | Astrodome (24-27) | 43-54 | Won 2 |
| » W: Joe Niekro (10-7) L: Mario Soto (8-7) | Fifth | 17 out |
| Thursday, July 29 |
| » Defeated Reds (37-63), 4-3 | Astrodome (25-27) | 44-54 | Won 3 |
| » W: Randy Moffitt (1-3) L: Greg Harris (2-3) S: Frank LaCorte (3) | Fifth | 17 out |
| Friday, July 30 |
| » Defeated Giants (48-53), 3-1 | Astrodome (26-27) | 45-54 | Won 4 |
| » W: Don Sutton (10-7) L: Rich Gale (5-10) | Fifth | 15½ out |
| Saturday, July 31 |
| » Lost to Giants (49-53), 5-4 | Astrodome (26-28) | 45-55 | |
| » W: Bill Laskey (9-8) L: Vern Ruhle (5-7) S: Greg Minton (17) | Fifth | 15 out |
| » Defeated Giants (49-54), 5-0 | Astrodome (27-28) | 46-55 | |
| » W: Mike LaCoss (4-3) L: Atlee Hammaker (8-6) S: Frank LaCorte (4) | Fifth | 15 out |
| Sunday, August 1 |
| » Lost to Giants (50-54), 4-2 | Astrodome (27-29) | 46-56 | |
| » W: Greg Minton (7-4) L: Frank LaCorte (0-4) | Fifth | 15 out |
| Monday, August 2 |
| » Defeated Padres (56-49), 6-4 | Astrodome (28-29) | 47-56 | |
| » W: Joe Niekro (11-7) L: Gary Lucas (0-8) S: Dave Smith (8) | Fifth | 15 out |
| Tuesday, August 3 |
| » Defeated Padres (56-50), 7-6 | Astrodome (29-29) | 48-56 | Won 2 |
| » W: Randy Moffitt (2-3) L: Luis DeLeon (4-4) | Fifth | 14 out |
| Wednesday, August 4 |
| » Lost to Padres (57-50), 5-2 | Astrodome (29-30) | 48-57 | |
| » W: John Montefusco (9-6) L: Don Sutton (10-8) | Fifth | 14 out |
| Thursday, August 5 |
| » Lost to Giants (53-55), 5-2 | Candlestick Park (1-2) | 48-58 | Lost 2 |
| » W: Bill Laskey (10-8) L: Vern Ruhle (5-8) S: Greg Minton (19) | Fifth | 14 out |
| Friday, August 6 |
| » Lost to Giants (54-55), 7-6 | Candlestick Park (1-3) | 48-59 | Lost 3 |
| » W: Gary Lavelle (6-5) L: Randy Moffitt (2-4) | Fifth | 14 out |
| Saturday, August 7 |
| » Lost to Giants (55-55), 9-2 | Candlestick Park (1-4) | 48-60 | Lost 4 |
| » W: Renie Martin (5-5) L: Joe Niekro (11-8) | Fifth | 14 out |
| Sunday, August 8 |
| » Lost to Giants (56-55), 3-2 | Candlestick Park (1-5) | 48-61 | Lost 5 |
| » W: Fred Breining (6-4) L: Bob Knepper (4-12) | Fifth | 14½ out |
| » Lost to Giants (57-55), 8-3 | Candlestick Park (1-6) | 48-62 | Lost 6 |
| » W: Gary Lavelle (7-5) L: Mike LaCoss (4-4) | Fifth | 14½ out |
| Monday, August 9 |
| » Defeated Padres (60-52), 4-3 | San Diego/Jack Murphy Stadium (1-4) | 49-62 | |
| » W: Don Sutton (11-8) L: John Montefusco (9-7) S: Dave Smith (9) | Fifth | 13½ out |
| Tuesday, August 10 |
| » Defeated Padres (60-53), 4-1 | San Diego/Jack Murphy Stadium (2-4) | 50-62 | Won 2 |
| » Manager: Bob Lillis |
| » W: Vern Ruhle (6-8) L: Tim Lollar (11-7) S: Randy Moffitt (2) | Fifth | 13 out |
| Wednesday, August 11 |
| » Defeated Padres (60-54), 3-0 | San Diego/Jack Murphy Stadium (3-4) | 51-62 | Won 3 |
| » W: Nolan Ryan (12-9) L: Eric Show (9-4) | Fifth | 12 out |
| Friday, August 13 |
| » Lost to Reds (42-73), 3-0 | Riverfront Stadium (1-2) | 51-63 | |
| » W: Frank Pastore (6-9) L: Joe Niekro (11-9) | Fifth | 13½ out |
| Saturday, August 14 |
| » Defeated Reds (42-74), 2-0 | Riverfront Stadium (2-2) | 52-63 | |
| » W: Bob Knepper (5-12) L: Bruce Berenyi (8-12) S: Randy Moffitt (3) | Fifth | 12½ out |
| Sunday, August 15 |
| » Defeated Reds (42-75), 7-3 | Riverfront Stadium (3-2) | 53-63 | Won 2 |
| » W: Don Sutton (12-8) L: Tom Seaver (5-13) S: Bert Roberge (2) | Fifth | 11½ out |
| Monday, August 16 |
| » Lost to Reds (43-75), 3-2 | Riverfront Stadium (3-3) | 53-64 | |
| » W: Jim Kern (2-5) L: Dave Smith (1-4) | Fifth | 12 out |
| Tuesday, August 17 |
| » Defeated Phillies (66-52), 2-0 | Astrodome (30-30) | 54-64 | |
| » W: Vern Ruhle (7-8) L: Larry Christenson (7-8) | Fifth | 11½ out |
| Wednesday, August 18 |
| » Lost to Phillies (67-52), 5-3 | Astrodome (30-31) | 54-65 | |
| » W: Tug McGraw (2-2) L: Mike LaCoss (4-5) | Fifth | 13 out |
| Thursday, August 19 |
| » Defeated Phillies (67-53), 7-6 | Astrodome (31-31) | 55-65 | |
| » W: Dave Smith (2-4) L: Sid Monge (5-1) | Fifth | 12 out |
| Friday, August 20 |
| » Defeated Expos (64-57), 4-3 | Astrodome (32-31) | 56-65 | Won 2 |
| » W: Bert Roberge (1-1) L: Jeff Reardon (5-3) | Fifth | 12 out |
| Saturday, August 21 |
| » Defeated Expos (64-58), 5-3 | Astrodome (33-31) | 57-65 | Won 3 |
| » W: Nolan Ryan (13-9) L: Ray Burris (4-13) | Fifth | 11 out |
| Sunday, August 22 |
| » Lost to Expos (65-58), 5-0 | Astrodome (33-32) | 57-66 | |
| » W: Charlie Lea (11-6) L: Vern Ruhle (7-9) | Fifth | 11 out |
| Monday, August 23 |
| » Defeated Mets (50-73), 2-0 | Astrodome (34-32) | 58-66 | |
| » W: Joe Niekro (12-9) L: Pat Zachry (6-6) | Fifth | 10 out |
| Tuesday, August 24 |
| » Defeated Mets (50-74), 5-4 | Astrodome (35-32) | 59-66 | Won 2 |
| » W: Dave Smith (3-4) L: Mike Scott (7-11) | Fifth | 10 out |
| Wednesday, August 25 |
| » Defeated Mets (50-75), 5-4 | Astrodome (36-32) | 60-66 | Won 3 |
| » W: Don Sutton (13-8) L: Ed Lynch (2-5) S: Bert Roberge (3) | Fifth | 10 out |
| Thursday, August 26 |
| » Lost to Expos (67-60), 3-2 | Stade Olympique (1-2) | 60-67 | |
| » W: Jeff Reardon (6-3) L: Bert Roberge (1-2) | Fifth | 11 out |
| » Lost to Expos (68-60), 5-3 | Stade Olympique (1-3) | 60-68 | Lost 2 |
| » W: Jeff Reardon (7-3) L: Vern Ruhle (7-10) S: Woodie Fryman (10) | Fifth | 11 out |
| Saturday, August 28 |
| » Defeated Expos (68-61), 2-0 | Stade Olympique (2-3) | 61-68 | |
| » W: Joe Niekro (13-9) L: Charlie Lea (11-7) | Fifth | 11½ out |
| Sunday, August 29 |
| » Lost to Expos (69-61), 5-3 | Stade Olympique (2-4) | 61-69 | |
| » W: Scott Sanderson (8-11) L: Bob Knepper (5-13) S: Bryn Smith (3) | Fifth | 11½ out |
| Monday, August 30 |
| » Defeated Mets (50-79), 4-2 | Shea Stadium (3-1) | 62-69 | |
| » W: Frank LaCorte (1-4) L: Craig Swan (7-6) S: Dave Smith (10) | Fifth | 11 out |
| Tuesday, August 31 |
| » Defeated Mets (50-80), 4-0 | Shea Stadium (4-1) | 63-69 | Won 2 |
| » W: Nolan Ryan (14-9) L: Ed Lynch (2-6) | Fifth | 11 out |
| Wednesday, September 1 |
| » Lost to Mets (51-80), 5-1 | Shea Stadium (4-2) | 63-70 | |
| » W: Pete Falcone (7-8) L: Vern Ruhle (7-11) | Fifth | 12 out |
| Friday, September 3 |
| » Lost to Phillies (74-60), 2-1 | Veteran's Stadium (3-1) | 63-71 | Lost 2 |
| » W: Steve Carlton (18-9) L: Joe Niekro (13-10) | Fifth | 13 out |
| Saturday, September 4 |
| » Lost to Phillies (75-60), 4-2 | Veteran's Stadium (3-2) | 63-72 | Lost 3 |
| » W: Sid Monge (6-1) L: Bob Knepper (5-14) S: Ron Reed (9) | Fifth | 13 out |
| Sunday, September 5 |
| » Lost to Phillies (76-60), 4-3 | Veteran's Stadium (3-3) | 63-73 | Lost 4 |
| » W: Porfi Altamirano (3-0) L: Nolan Ryan (14-10) S: Ron Reed (10) | Fifth | 13 out |
| Monday, September 6 |
| » Lost to Padres (72-66), 4-2 | Astrodome (36-33) | 63-74 | Lost 5 |
| » W: Chris Welsh (8-5) L: Vern Ruhle (7-12) | Fifth | 13 out |
| » Major-league debuts: Bill Doran (Astros) |
| Tuesday, September 7 |
| » Defeated Padres (72-67), 4-3 | Astrodome (37-33) | 64-74 | |
| » W: Frank DiPino (1-0) L: Juan Eichelberger (7-12) S: Danny Boone (2) | Fifth | 12½ out |
| Wednesday, September 8 |
| » Defeated Giants (71-68), 8-1 | Astrodome (38-33) | 65-74 | Won 2 |
| » W: Joe Niekro (14-10) L: Atlee Hammaker (9-8) | Fifth | 12 out |
| Thursday, September 9 |
| » Lost to Giants (72-68), 5-1 | Astrodome (38-34) | 65-75 | |
| » W: Renie Martin (6-8) L: Mike LaCoss (4-6) S: Greg Minton (27) | Fifth | 13 out |
| Friday, September 10 |
| » Lost to Dodgers (78-64), 3-2 | Astrodome (38-35) | 65-76 | Lost 2 |
| » W: Steve Howe (7-4) L: Nolan Ryan (14-11) S: Tom Niedenfuer (9) | Fifth | 14 out |
| Saturday, September 11 |
| » Lost to Dodgers (79-64), 5-3 | Astrodome (38-36) | 65-77 | Lost 3 |
| » W: Jerry Reuss (15-10) L: Vern Ruhle (7-13) S: Steve Howe (13) | Fifth | 14 out |
| Sunday, September 12 |
| » Lost to Dodgers (80-64), 7-3 | Astrodome (38-37) | 65-78 | Lost 4 |
| » W: Dave Stewart (9-7) L: Frank DiPino (1-1) | Fifth | 15 out |
| Monday, September 13 |
| » Defeated Braves (80-64), 5-3 | Atlanta-Fulton County Stadium (2-5) | 66-78 | |
| » W: Joe Niekro (15-10) L: Phil Niekro (14-4) | Fifth | 14½ out |
| Tuesday, September 14 |
| » Defeated Braves (80-65), 4-0 | Atlanta-Fulton County Stadium (3-5) | 67-78 | Won 2 |
| » W: Mike LaCoss (5-6) L: Rick Mahler (9-10) S: Frank LaCorte (5) | Fifth | 14½ out |
| Wednesday, September 15 |
| » Defeated Braves (80-66), 5-4 | Atlanta-Fulton County Stadium (4-5) | 68-78 | Won 3 |
| » W: Nolan Ryan (15-11) L: Tommy Boggs (2-2) S: Dave Smith (11) | Fifth | 14½ out |
| Friday, September 17 |
| » Lost to Dodgers (84-64), 9-2 | Dodger Stadium (3-4) | 68-79 | |
| » W: Jerry Reuss (17-10) L: Frank DiPino (1-2) | Fifth | 15½ out |
| Saturday, September 18 |
| » Defeated Dodgers (84-65), 2-0 | Dodger Stadium (4-4) | 69-79 | |
| » W: Joe Niekro (16-10) L: Bob Welch (15-11) | Fifth | 14½ out |
| Sunday, September 19 |
| » Lost to Dodgers (85-65), 5-4 | Dodger Stadium (4-5) | 69-80 | |
| » W: Fernando Valenzuela (19-12) L: Frank LaCorte (1-5) | Fifth | 15½ out |
| Monday, September 20 |
| » Defeated Braves (82-68), 4-3 | Astrodome (39-37) | 70-80 | |
| » W: Dave Smith (4-4) L: Gene Garber (7-9) | Fifth | 15 out |
| Tuesday, September 21 |
| » Defeated Braves (82-69), 5-3 | Astrodome (40-37) | 71-80 | Won 2 |
| » W: Vern Ruhle (8-13) L: Rick Camp (11-10) S: Bob Knepper (1) | Fifth | 14 out |
| Wednesday, September 22 |
| » Defeated Braves (82-70), 3-2 | Astrodome (41-37) | 72-80 | Won 3 |
| » W: Dave Smith (5-4) L: Gene Garber (7-10) S: Frank LaCorte (6) | Fifth | 13 out |
| Friday, September 24 |
| » Lost to Reds (57-96), 2-0 | Riverfront Stadium (3-4) | 72-81 | |
| » W: Bruce Berenyi (9-18) L: Joe Niekro (16-11) | Fifth | 13 out |
| Saturday, September 25 |
| » Defeated Reds (57-97), 3-1 | Riverfront Stadium (4-4) | 73-81 | |
| » W: Mike LaCoss (6-6) L: Bill Scherrer (0-1) S: Frank LaCorte (7) | Fifth | 12 out |
| Sunday, September 26 |
| » Defeated Reds (57-98), 4-0 | Riverfront Stadium (5-4) | 74-81 | Won 2 |
| » W: Nolan Ryan (16-11) L: Bob Shirley (7-13) | Fourth | 11 out |
| Monday, September 27 |
| » Defeated Padres (78-78), 7-3 | San Diego/Jack Murphy Stadium (4-4) | 75-81 | Won 3 |
| » W: Vern Ruhle (9-13) L: Chris Welsh (8-8) | Fourth | 10 out |
| Tuesday, September 28 |
| » Lost to Padres (79-78), 3-0 | San Diego/Jack Murphy Stadium (4-5) | 75-82 | |
| » W: Tim Lollar (15-9) L: Bob Knepper (5-15) S: Luis DeLeon (15) | Fifth | 11 out |
| Wednesday, September 29 |
| » Lost to Giants (85-73), 6-1 | Candlestick Park (1-7) | 75-83 | Lost 2 |
| » W: Atlee Hammaker (12-8) L: Joe Niekro (16-12) S: Gary Lavelle (8) | Fourth | 12 out |
| Thursday, September 30 |
| » Lost to Giants (86-73), 7-6 | Candlestick Park (1-8) | 75-84 | Lost 3 |
| » W: Gary Lavelle (10-7) L: Danny Boone (1-1) | Fourth | 12 out |
| Friday, October 1 |
| » Lost to Reds (61-99), 4-2 | Astrodome (41-38) | 75-85 | Lost 4 |
| » W: Bob Shirley (8-13) L: Nolan Ryan (16-12) S: Joe Price (3) | Fifth | 13 out |
| Saturday, October 2 |
| » Defeated Reds (61-100), 4-2 | Astrodome (42-38) | 76-85 | |
| » W: Frank DiPino (2-2) L: Mario Soto (14-13) S: Vern Ruhle (1) | Fifth | 13 out |
| Sunday, October 3 |
| » Defeated Reds (61-101), 3-0 | Astrodome (43-38) | 77-85 | Won 2 |
| » W: Joe Niekro (17-12) L: Frank Pastore (8-13) | Fifth | 12 out |
| Monday, November 29 |
| Former Astro Al Cicotte dies in Westland, MI at the age of 53. |
Game information provided by Retrosheet (www.retrosheet.org) |