| Tuesday, January 20 |
| Future Padre Freddy Guzman is born in Santo Domingo, D.R. |
| Thursday, April 9 |
| » Defeated Giants (0-1), 4-1 | Candlestick Park (1-0) | 1-0 | |
| » W: Gary Lucas (1-0) L: Al Holland (0-1) S: John Littlefield (1) | First | -- |
| » Major-league debuts: Juan Bonilla (Padres) |
| Friday, April 10 |
| » Defeated Giants (0-2), 4-2 | Candlestick Park (2-0) | 2-0 | Won 2 |
| » W: John Urrea (1-0) L: Gary Lavelle (0-1) S: John Littlefield (2) | First | -- |
| » Major-league debuts: Chili Davis (Giants) |
| Saturday, April 11 |
| » Lost to Giants (1-2), 2-0 | Candlestick Park (2-1) | 2-1 | |
| » W: Doyle Alexander (1-0) L: Juan Eichelberger (0-1) S: Greg Minton (1) | Second | ½ out |
| Sunday, April 12 |
| » Lost to Giants (2-2), 7-6 | Candlestick Park (2-2) | 2-2 | Lost 2 |
| » W: Fred Breining (1-0) L: Gary Lucas (1-1) | Third | 1½ out |
| » Major-league debuts: Chris Welsh (Padres) |
| Monday, April 13 |
| » Lost to Reds (3-2), 7-1 | San Diego/Jack Murphy Stadium (0-1) | 2-3 | Lost 3 |
| » W: Tom Seaver (1-0) L: Rick Wise (0-1) | Fourth | 2½ out |
| Tuesday, April 14 |
| » Lost to Reds (4-2), 4-0 | San Diego/Jack Murphy Stadium (0-2) | 2-4 | Lost 4 |
| » W: Bruce Berenyi (1-0) L: John Curtis (0-1) | Fourth | 3½ out |
| Wednesday, April 15 |
| » Lost to Reds (5-2), 10-1 | San Diego/Jack Murphy Stadium (0-3) | 2-5 | Lost 5 |
| » W: Mario Soto (1-1) L: Steve Mura (0-1) | Fifth | 4½ out |
| Friday, April 17 |
| » Defeated Dodgers (6-1), 3-2 | San Diego/Jack Murphy Stadium (1-3) | 3-5 | |
| » W: Tim Lollar (1-0) L: Steve Howe (0-1) | Fourth | 3½ out |
| Saturday, April 18 |
| » Lost to Dodgers (7-1), 2-0 | San Diego/Jack Murphy Stadium (1-4) | 3-6 | |
| » W: Fernando Valenzuela (3-0) L: Rick Wise (0-2) | Fifth | 4½ out |
| Sunday, April 19 |
| » Lost to Dodgers (8-1), 6-1 | San Diego/Jack Murphy Stadium (1-5) | 3-7 | Lost 2 |
| » W: Bob Welch (1-0) L: John Curtis (0-2) S: Bobby Castillo (3) | Fifth | 5½ out |
| Monday, April 20 |
| » Lost to Giants (5-6), 9-0 | San Diego/Jack Murphy Stadium (1-6) | 3-8 | Lost 3 |
| » W: Vida Blue (1-1) L: Steve Mura (0-2) S: Gary Lavelle (1) | Fifth | 6½ out |
| Tuesday, April 21 |
| » Defeated Giants (5-7), 3-1 | San Diego/Jack Murphy Stadium (2-6) | 4-8 | |
| » W: Chris Welsh (1-0) L: Doyle Alexander (2-1) S: Gary Lucas (1) | Fourth | 5½ out |
| Wednesday, April 22 |
| » Defeated Giants (5-8), 4-0 | San Diego/Jack Murphy Stadium (3-6) | 5-8 | Won 2 |
| » W: Juan Eichelberger (1-1) L: Ed Whitson (0-2) S: Gary Lucas (2) | Fourth | 5½ out |
| Thursday, April 23 |
| » Lost to Dodgers (11-2), 3-1 | Dodger Stadium (0-1) | 5-9 | |
| » W: Rick Sutcliffe (2-0) L: Rick Wise (0-3) S: Steve Howe (2) | Fourth | 6½ out |
| Friday, April 24 |
| » Defeated Dodgers (11-3), 6-5 | Dodger Stadium (1-1) | 6-9 | |
| » W: Gary Lucas (2-1) L: Bobby Castillo (0-1) S: Tim Lollar (1) | Fourth | 5½ out |
| Saturday, April 25 |
| » Lost to Dodgers (12-3), 2-1 | Dodger Stadium (1-2) | 6-10 | |
| » W: Steve Howe (1-1) L: John Littlefield (0-1) | Fourth | 6½ out |
| Sunday, April 26 |
| » Lost to Dodgers (13-3), 3-2 | Dodger Stadium (1-3) | 6-11 | Lost 2 |
| » W: Jerry Reuss (1-1) L: Gary Lucas (2-2) | Fifth | 7½ out |
| Tuesday, April 28 |
| » Lost to Reds (9-7), 11-2 | Riverfront Stadium (0-1) | 6-12 | Lost 3 |
| » W: Tom Seaver (2-1) L: Tim Lollar (1-1) | Fifth | 8 out |
| Wednesday, April 29 |
| » Lost to Reds (10-7), 8-5 | Riverfront Stadium (0-2) | 6-13 | Lost 4 |
| » W: Paul Moskau (1-0) L: John Littlefield (0-2) S: Tom Hume (2) | Sixth | 8 out |
| Thursday, April 30 |
| » Lost to Reds (11-7), 4-3 | Riverfront Stadium (0-3) | 6-14 | Lost 5 |
| » W: Mike LaCoss (1-2) L: Steve Mura (0-3) S: Tom Hume (3) | Sixth | 8½ out |
| Friday, May 1 |
| » Defeated Mets (4-11), 4-2 | Shea Stadium (1-0) | 7-14 | |
| » W: John Urrea (2-0) L: Pat Zachry (3-2) S: Gary Lucas (3) | Sixth | 7½ out |
| Saturday, May 2 |
| » Lost to Mets (5-11), 6-2 | Shea Stadium (1-1) | 7-15 | |
| » W: Pete Falcone (1-0) L: Chris Welsh (1-1) | Sixth | 8½ out |
| Sunday, May 3 |
| » Defeated Mets (5-12), 4-1 | Shea Stadium (2-1) | 8-15 | |
| » W: Rick Wise (1-3) L: Dave Roberts (0-2) S: Gary Lucas (4) | Sixth | 9 out |
| » Lost to Mets (6-12), 7-4 | Shea Stadium (2-2) | 8-16 | |
| » W: Mike Scott (1-2) L: Tim Lollar (1-2) S: Neil Allen (3) | Sixth | 9 out |
| Tuesday, May 5 |
| » Lost to Expos (15-6), 4-3 | Stade Olympique (0-1) | 8-17 | Lost 2 |
| » W: Woodie Fryman (2-0) L: Steve Mura (0-4) | Sixth | 8½ out |
| Wednesday, May 6 |
| » Defeated Expos (15-7), 13-5 | Stade Olympique (1-1) | 9-17 | |
| » W: Juan Eichelberger (2-1) L: Ray Burris (2-2) | Sixth | 8½ out |
| » Major-league debuts: Mike Gates (Expos) |
| Thursday, May 7 |
| » Lost to Expos (16-7), 2-1 | Stade Olympique (1-2) | 9-18 | |
| » W: Scott Sanderson (4-1) L: Chris Welsh (1-2) | Sixth | 9½ out |
| Friday, May 8 |
| » Lost to Phillies (17-9), 11-7 | Veteran's Stadium (0-1) | 9-19 | Lost 2 |
| » W: Sparky Lyle (3-1) L: Gary Lucas (2-3) | Sixth | 10½ out |
| Saturday, May 9 |
| » Lost to Phillies (18-9), 9-6 | Veteran's Stadium (0-2) | 9-20 | Lost 3 |
| » W: Steve Carlton (6-0) L: Tim Lollar (1-3) | Sixth | 10½ out |
| Sunday, May 10 |
| » Defeated Phillies (18-10), 8-4 | Veteran's Stadium (1-2) | 10-20 | |
| » W: Steve Mura (1-4) L: Larry Christenson (1-3) S: Gary Lucas (5) | Sixth | 10½ out |
| Tuesday, May 12 |
| » Defeated Mets (8-17), 3-0 | San Diego/Jack Murphy Stadium (4-6) | 11-20 | Won 2 |
| » W: Juan Eichelberger (3-1) L: Pat Zachry (3-4) | Sixth | 10½ out |
| Wednesday, May 13 |
| » Defeated Mets (8-18), 5-0 | San Diego/Jack Murphy Stadium (5-6) | 12-20 | Won 3 |
| » W: Chris Welsh (2-2) L: Ed Lynch (1-1) | Sixth | 10½ out |
| Thursday, May 14 |
| » Defeated Mets (8-19), 10-6 | San Diego/Jack Murphy Stadium (6-6) | 13-20 | Won 4 |
| » W: Gary Lucas (3-3) L: Pete Falcone (1-1) | Fifth | 10½ out |
| Friday, May 15 |
| » Lost to Phillies (20-12), 2-1 | San Diego/Jack Murphy Stadium (6-7) | 13-21 | |
| » W: Steve Carlton (7-0) L: Steve Mura (1-5) | Fifth | 11½ out |
| Saturday, May 16 |
| » Defeated Phillies (20-13), 2-1 | San Diego/Jack Murphy Stadium (7-7) | 14-21 | |
| » W: John Littlefield (1-2) L: Tug McGraw (1-3) | Sixth | 11½ out |
| Sunday, May 17 |
| » Lost to Phillies (21-13), 6-3 | San Diego/Jack Murphy Stadium (7-8) | 14-22 | |
| » W: Nino Espinosa (2-3) L: Juan Eichelberger (3-2) | Sixth | 12½ out |
| Monday, May 18 |
| » Lost to Expos (19-15), 3-2 | San Diego/Jack Murphy Stadium (7-9) | 14-23 | Lost 2 |
| » W: Woodie Fryman (3-1) L: Gary Lucas (3-4) S: Bill Lee (2) | Sixth | 12½ out |
| Tuesday, May 19 |
| » Defeated Expos (19-16), 3-1 | San Diego/Jack Murphy Stadium (8-9) | 15-23 | |
| » W: Rick Wise (2-3) L: Bill Gullickson (1-4) S: Gary Lucas (6) | Sixth | 11½ out |
| Wednesday, May 20 |
| » Lost to Expos (20-16), 6-2 | San Diego/Jack Murphy Stadium (8-10) | 15-24 | |
| » W: Steve Rogers (4-3) L: Steve Mura (1-6) | Sixth | 12½ out |
| Friday, May 22 |
| » Defeated Braves (18-19), 5-2 | Atlanta-Fulton County Stadium (1-0) | 16-24 | |
| » W: Juan Eichelberger (4-2) L: Tommy Boggs (1-7) S: Gary Lucas (7) | Sixth | 12½ out |
| Saturday, May 23 |
| » Lost to Braves (19-19), 7-6 | Atlanta-Fulton County Stadium (1-1) | 16-25 | |
| » W: Rick Camp (4-1) L: Gary Lucas (3-5) | Sixth | 13½ out |
| Sunday, May 24 |
| » Defeated Braves (19-20), 7-5 | Atlanta-Fulton County Stadium (2-1) | 17-25 | |
| » W: John Curtis (1-2) L: Phil Niekro (2-3) S: Danny Boone (1) | Sixth | 13 out |
| Monday, May 25 |
| » Lost to Astros (21-22), 6-3 | Astrodome (0-1) | 17-26 | |
| » W: Joe Niekro (6-3) L: Steve Mura (1-7) S: Joe Sambito (4) | Sixth | 14 out |
| Tuesday, May 26 |
| » Lost to Astros (22-22), 1-0 | Astrodome (0-2) | 17-27 | Lost 2 |
| » W: Nolan Ryan (4-2) L: Juan Eichelberger (4-3) S: Joe Sambito (5) | Sixth | 14½ out |
| Wednesday, May 27 |
| » Lost to Astros (23-22), 1-0 | Astrodome (0-3) | 17-28 | Lost 3 |
| » W: Bob Knepper (5-0) L: Chris Welsh (2-3) | Sixth | 14½ out |
| Friday, May 29 |
| » Lost to Braves (22-21), 7-1 | San Diego/Jack Murphy Stadium (8-11) | 17-29 | Lost 4 |
| » W: Phil Niekro (3-3) L: Rick Wise (2-4) S: Rick Camp (5) | Sixth | 15 out |
| Saturday, May 30 |
| » Defeated Braves (22-22), 11-1 | San Diego/Jack Murphy Stadium (9-11) | 18-29 | |
| » W: Steve Mura (2-7) L: Preston Hanna (2-1) | Sixth | 14 out |
| Sunday, May 31 |
| » Defeated Braves (22-23), 5-1 | San Diego/Jack Murphy Stadium (10-11) | 19-29 | Won 2 |
| » W: Juan Eichelberger (5-3) L: Rick Mahler (2-1) | Sixth | 14 out |
| Future Padre Jake Peavy is born in Mobile, AL. |
| Tuesday, June 2 |
| » Lost to Astros (25-24), 2-1 | San Diego/Jack Murphy Stadium (10-12) | 19-30 | |
| » W: Frank LaCorte (3-1) L: Chris Welsh (2-4) S: Joe Sambito (6) | Sixth | 14½ out |
| Wednesday, June 3 |
| » Lost to Astros (26-24), 6-1 | San Diego/Jack Murphy Stadium (10-13) | 19-31 | Lost 2 |
| » W: Don Sutton (4-6) L: Rick Wise (2-5) | Sixth | 14½ out |
| Thursday, June 4 |
| » Defeated Astros (26-25), 7-5 | San Diego/Jack Murphy Stadium (11-13) | 20-31 | |
| » W: Steve Mura (3-7) L: Joe Niekro (6-4) S: Gary Lucas (8) | Sixth | 14 out |
| Friday, June 5 |
| » Lost to Cardinals (27-18), 2-1 | Busch Stadium II (0-1) | 20-32 | |
| » W: Jim Kaat (3-1) L: John Curtis (1-3) | Sixth | 14 out |
| Saturday, June 6 |
| » Lost to Cardinals (28-18), 11-1 | Busch Stadium II (0-2) | 20-33 | Lost 2 |
| » W: John Martin (3-1) L: Tim Lollar (1-4) | Sixth | 14 out |
| Sunday, June 7 |
| » Defeated Cardinals (28-19), 5-1 | Busch Stadium II (1-2) | 21-33 | |
| » W: Chris Welsh (3-4) L: Bob Shirley (4-3) | Sixth | 14 out |
| Tuesday, June 9 |
| » Defeated Pirates (25-22), 7-4 | Three Rivers Stadium (1-0) | 22-33 | Won 2 |
| » W: Steve Mura (4-7) L: Rick Rhoden (6-1) S: Gary Lucas (9) | Sixth | 13 out |
| Wednesday, June 10 |
| » Defeated Pirates (25-23), 3-2 | Three Rivers Stadium (2-0) | 23-33 | Won 3 |
| » W: Juan Eichelberger (6-3) L: Pascual Perez (2-2) S: Gary Lucas (10) | Sixth | 13 out |
| Monday, August 10 |
| » Lost to Braves (26-29), 3-2 | San Diego/Jack Murphy Stadium (11-14) | 23-34 | |
| » W: Gene Garber (2-1) L: John Urrea (2-1) S: Rick Camp (9) | Sixth | 13½ out |
| Tuesday, August 11 |
| » Lost to Braves (27-29), 5-1 | San Diego/Jack Murphy Stadium (11-15) | 23-35 | Lost 2 |
| » W: Gaylord Perry (6-4) L: Steve Mura (4-8) | Sixth | 13½ out |
| Wednesday, August 12 |
| » Lost to Braves (28-29), 4-3 | San Diego/Jack Murphy Stadium (11-16) | 23-36 | Lost 3 |
| » W: Rick Camp (6-1) L: John Curtis (1-4) S: John Montefusco (1) | Sixth | 14½ out |
| Thursday, August 13 |
| » Defeated Astros (30-31), 9-1 | San Diego/Jack Murphy Stadium (12-16) | 24-36 | |
| » W: Chris Welsh (4-4) L: Bob Knepper (5-2) | Sixth | 13½ out |
| Friday, August 14 |
| » Lost to Astros (31-31), 5-1 | San Diego/Jack Murphy Stadium (12-17) | 24-37 | |
| » W: Nolan Ryan (6-3) L: Tim Lollar (1-5) | Sixth | 14½ out |
| Saturday, August 15 |
| » Lost to Astros (32-31), 5-0 | San Diego/Jack Murphy Stadium (12-18) | 24-38 | Lost 2 |
| » W: Don Sutton (5-7) L: Juan Eichelberger (6-4) | Sixth | 14½ out |
| Future Padre Oliver Perez is born in Culiacan, Mexico. |
| Sunday, August 16 |
| » Lost to Astros (33-31), 3-0 | San Diego/Jack Murphy Stadium (12-19) | 24-39 | Lost 3 |
| » W: Joe Niekro (7-6) L: Steve Mura (4-9) S: Dave Smith (4) | Sixth | 15½ out |
| Monday, August 17 |
| » Lost to Cardinals (35-21), 2-1 | Busch Stadium II (1-3) | 24-40 | Lost 4 |
| » W: Jim Kaat (4-2) L: Gary Lucas (3-6) | Sixth | 15½ out |
| Tuesday, August 18 |
| » Defeated Cardinals (35-22), 4-3 | Busch Stadium II (2-3) | 25-40 | |
| » W: Chris Welsh (5-4) L: Silvio Martinez (2-5) S: John Urrea (1) | Sixth | 15½ out |
| Wednesday, August 19 |
| » Lost to Cardinals (36-22), 7-6 | Busch Stadium II (2-4) | 25-41 | |
| » W: Bruce Sutter (3-3) L: John Littlefield (1-3) | Sixth | 15½ out |
| Thursday, August 20 |
| » Major-league debuts: Brett Butler (Braves) |
| Friday, August 21 |
| » Lost to Pirates (29-30), 4-2 | Three Rivers Stadium (2-1) | 25-42 | Lost 2 |
| » W: Rick Rhoden (7-1) L: Steve Mura (4-10) S: Grant Jackson (4) | Sixth | 17 out |
| » Lost to Pirates (30-30), 3-2 | Three Rivers Stadium (2-2) | 25-43 | Lost 3 |
| » W: Jim Bibby (5-3) L: Tim Lollar (1-6) S: Kent Tekulve (2) | Sixth | 17 out |
| Saturday, August 22 |
| » Defeated Pirates (30-31), 7-6 | Three Rivers Stadium (3-2) | 26-43 | |
| » W: John Curtis (2-4) L: Kent Tekulve (4-4) S: Gary Lucas (11) | Sixth | 17 out |
| Sunday, August 23 |
| » Lost to Pirates (31-31), 5-2 | Three Rivers Stadium (3-3) | 26-44 | |
| » W: Rod Scurry (3-4) L: Chris Welsh (5-5) S: Enrique Romo (9) | Sixth | 17 out |
| Monday, August 24 |
| » Lost to Cubs (22-44), 9-8 | Wrigley Field (0-1) | 26-45 | Lost 2 |
| » W: Lee Smith (2-5) L: Gary Lucas (3-7) | Sixth | 18 out |
| Tuesday, August 25 |
| » Lost to Cubs (23-44), 4-3 | Wrigley Field (0-2) | 26-46 | Lost 3 |
| » W: Ken Kravec (1-3) L: Tim Lollar (1-7) S: Willie Hernandez (1) | Sixth | 19 out |
| Wednesday, August 26 |
| » Lost to Cubs (24-44), 9-7 | Wrigley Field (0-3) | 26-47 | Lost 4 |
| » W: Lee Smith (3-5) L: John Curtis (2-5) | Sixth | 20 out |
| Thursday, August 27 |
| » Lost to Cardinals (40-25), 3-2 | San Diego/Jack Murphy Stadium (12-20) | 26-48 | Lost 5 |
| » W: Jim Kaat (6-2) L: John Curtis (2-6) | Sixth | 21 out |
| Saturday, August 29 |
| » Lost to Cardinals (41-25), 6-1 | San Diego/Jack Murphy Stadium (12-21) | 26-49 | Lost 6 |
| » W: Lary Sorensen (6-5) L: Chris Welsh (5-6) S: Bob Shirley (1) | Sixth | 22 out |
| » Lost to Cardinals (42-25), 6-5 | San Diego/Jack Murphy Stadium (12-22) | 26-50 | Lost 7 |
| » W: Bob Sykes (2-0) L: Juan Eichelberger (6-5) S: Bruce Sutter (17) | Sixth | 22 out |
| Sunday, August 30 |
| » Defeated Cardinals (42-26), 9-6 | San Diego/Jack Murphy Stadium (13-22) | 27-50 | |
| » W: Gary Lucas (4-7) L: Mark Littell (0-1) | Sixth | 21 out |
| Monday, August 31 |
| » Defeated Cubs (26-47), 4-1 | San Diego/Jack Murphy Stadium (14-22) | 28-50 | Won 2 |
| » W: Steve Mura (5-10) L: Ken Kravec (1-4) | Sixth | 20 out |
| Tuesday, September 1 |
| » Defeated Cubs (26-48), 3-2 | San Diego/Jack Murphy Stadium (15-22) | 29-50 | Won 3 |
| » W: Rick Wise (3-5) L: Mike Krukow (4-8) S: John Urrea (2) | Sixth | 20 out |
| Wednesday, September 2 |
| » Defeated Cubs (26-49), 5-4 | San Diego/Jack Murphy Stadium (16-22) | 30-50 | Won 4 |
| » W: Gary Lucas (5-7) L: Dick Tidrow (2-7) | Sixth | 20 out |
| » Major-league debuts: Ryne Sandberg (Cubs) |
| Thursday, September 3 |
| » Lost to Pirates (33-40), 7-3 | San Diego/Jack Murphy Stadium (16-23) | 30-51 | |
| » W: Luis Tiant (1-3) L: Juan Eichelberger (6-6) S: Rod Scurry (2) | Sixth | 20 out |
| Friday, September 4 |
| » Defeated Pirates (33-41), 5-4 | San Diego/Jack Murphy Stadium (17-23) | 31-51 | |
| » W: John Littlefield (2-3) L: Don Robinson (0-3) S: Eric Show (1) | Sixth | 19 out |
| » Major-league debuts: Alan Wiggins (Padres) |
| Saturday, September 5 |
| » Lost to Pirates (34-41), 2-1 | San Diego/Jack Murphy Stadium (17-24) | 31-52 | |
| » W: Rick Rhoden (8-2) L: Steve Mura (5-11) S: Rod Scurry (3) | Sixth | 20 out |
| Sunday, September 6 |
| » Lost to Pirates (35-41), 9-5 | San Diego/Jack Murphy Stadium (17-25) | 31-53 | Lost 2 |
| » W: Eddie Solomon (6-4) L: Rick Wise (3-6) S: Don Robinson (2) | Sixth | 21 out |
| Monday, September 7 |
| » Lost to Reds (49-34), 8-7 | Riverfront Stadium (0-4) | 31-54 | Lost 3 |
| » W: Tom Seaver (11-2) L: Eric Show (0-1) S: Joe Price (3) | Sixth | 22 out |
| Tuesday, September 8 |
| » Defeated Reds (49-35), 6-1 | Riverfront Stadium (1-4) | 32-54 | |
| » W: Juan Eichelberger (7-6) L: Bruce Berenyi (7-5) | Sixth | 22 out |
| Wednesday, September 9 |
| » Lost to Reds (50-35), 5-4 | Riverfront Stadium (1-5) | 32-55 | |
| » W: Tom Hume (8-3) L: John Urrea (2-2) | Sixth | 22 out |
| Friday, September 11 |
| » Lost to Braves (42-42), 4-1 | Atlanta-Fulton County Stadium (2-2) | 32-56 | Lost 2 |
| » W: Gaylord Perry (7-6) L: Steve Mura (5-12) S: Rick Camp (14) | Sixth | 22 out |
| Saturday, September 12 |
| » Lost to Braves (43-42), 5-4 | Atlanta-Fulton County Stadium (2-3) | 32-57 | Lost 3 |
| » W: Rick Camp (9-2) L: Mike Armstrong (0-1) | Sixth | 22 out |
| » Major-league debuts: Albert Hall (Braves) |
| Sunday, September 13 |
| » Defeated Braves (43-43), 6-4 | Atlanta-Fulton County Stadium (3-3) | 33-57 | |
| » W: Gary Lucas (6-7) L: Rick Camp (9-3) S: Eric Show (2) | Sixth | 22 out |
| » Major-league debuts: Brook Jacoby (Braves) |
| Monday, September 14 |
| » Lost to Dodgers (56-35), 10-5 | San Diego/Jack Murphy Stadium (17-26) | 33-58 | |
| » W: Ted Power (1-1) L: Eric Show (0-2) | Sixth | 23 out |
| » Major-league debuts: Alejandro Pena (Dodgers) |
| Tuesday, September 15 |
| » Defeated Dodgers (56-36), 8-2 | San Diego/Jack Murphy Stadium (18-26) | 34-58 | |
| » W: Juan Eichelberger (8-6) L: Dave Goltz (2-4) | Sixth | 22 out |
| Wednesday, September 16 |
| » Lost to Astros (51-42), 5-2 | San Diego/Jack Murphy Stadium (18-27) | 34-59 | |
| » W: Don Sutton (9-8) L: Tim Lollar (1-8) S: Joe Sambito (10) | Sixth | 23 out |
| Thursday, September 17 |
| » Lost to Astros (52-42), 9-0 | San Diego/Jack Murphy Stadium (18-28) | 34-60 | Lost 2 |
| » W: Joe Niekro (9-7) L: Steve Mura (5-13) | Sixth | 24 out |
| Friday, September 18 |
| » Lost to Braves (44-47), 3-0 | San Diego/Jack Murphy Stadium (18-29) | 34-61 | Lost 3 |
| » W: Larry McWilliams (1-0) L: Rick Wise (3-7) | Sixth | 24 out |
| Saturday, September 19 |
| » Defeated Braves (44-48), 6-3 | San Diego/Jack Murphy Stadium (19-29) | 35-61 | |
| » W: Eric Show (1-2) L: Gene Garber (4-5) | Sixth | 23 out |
| Sunday, September 20 |
| » Lost to Braves (45-48), 3-1 | San Diego/Jack Murphy Stadium (19-30) | 35-62 | |
| » W: Al Hrabosky (1-1) L: Steve Mura (5-14) S: Rick Camp (15) | Sixth | 24 out |
| Monday, September 21 |
| » Defeated Reds (58-38), 6-0 | San Diego/Jack Murphy Stadium (20-30) | 36-62 | |
| » W: Chris Welsh (6-6) L: Charlie Leibrandt (1-1) | Sixth | 23 out |
| Tuesday, September 22 |
| » Lost to Reds (59-38), 3-2 | San Diego/Jack Murphy Stadium (20-31) | 36-63 | |
| » W: Tom Seaver (13-2) L: Juan Eichelberger (8-7) S: Tom Hume (11) | Sixth | 24 out |
| Wednesday, September 23 |
| » Lost to Reds (60-38), 5-1 | San Diego/Jack Murphy Stadium (20-32) | 36-64 | Lost 2 |
| » W: Frank Pastore (4-7) L: Rick Wise (3-8) S: Joe Price (4) | Sixth | 25 out |
| Friday, September 25 |
| » Lost to Giants (51-51), 3-0 | San Diego/Jack Murphy Stadium (20-33) | 36-65 | Lost 3 |
| » W: Al Holland (7-5) L: Steve Fireovid (0-1) S: Greg Minton (18) | Sixth | 26 out |
| Saturday, September 26 |
| » Lost to Giants (52-51), 6-5 | San Diego/Jack Murphy Stadium (20-34) | 36-66 | Lost 4 |
| » W: Gary Lavelle (2-6) L: Mike Armstrong (0-2) S: Greg Minton (19) | Sixth | 27 out |
| Sunday, September 27 |
| » Lost to Giants (53-51), 7-3 | San Diego/Jack Murphy Stadium (20-35) | 36-67 | Lost 5 |
| » W: Doyle Alexander (10-7) L: Chris Welsh (6-7) | Sixth | 28 out |
| Monday, September 28 |
| » Lost to Astros (59-45), 2-1 | Astrodome (0-4) | 36-68 | Lost 6 |
| » W: Joe Sambito (5-5) L: Juan Eichelberger (8-8) | Sixth | 28 out |
| Tuesday, September 29 |
| » Defeated Astros (59-46), 2-1 | Astrodome (1-4) | 37-68 | |
| » W: Rick Wise (4-8) L: Bob Knepper (9-5) S: Gary Lucas (12) | Sixth | 28 out |
| Wednesday, September 30 |
| » Defeated Dodgers (61-45), 2-0 | Dodger Stadium (2-3) | 38-68 | Won 2 |
| » W: Danny Boone (1-0) L: Dave Goltz (2-6) S: Gary Lucas (13) | Sixth | 28 out |
| Thursday, October 1 |
| » Defeated Dodgers (61-46), 1-0 | Dodger Stadium (3-3) | 39-68 | Won 3 |
| » W: Fred Kuhaulua (1-0) L: Fernando Valenzuela (13-7) S: Eric Show (3) | Sixth | 27 out |
| Saturday, October 3 |
| » Defeated Giants (55-54), 4-3 | Candlestick Park (3-2) | 40-68 | Won 4 |
| » W: Gary Lucas (7-7) L: Mike Rowland (0-1) S: Danny Boone (2) | Sixth | 25 out |
| » Defeated Giants (55-55), 7-2 | Candlestick Park (4-2) | 41-68 | Won 5 |
| » W: Tim Lollar (2-8) L: Alan Hargesheimer (1-2) | Sixth | 25 out |
| Sunday, October 4 |
| » Lost to Giants (56-55), 4-3 | Candlestick Park (4-3) | 41-69 | |
| » W: Fred Breining (5-2) L: Eric Show (1-3) S: Greg Minton (21) | Sixth | 26 out |
Game information provided by Retrosheet (www.retrosheet.org) |