| Friday, January 30 |
| Former Indian Marino Pieretti dies in San Francisco, CA at the age of 61. |
| Friday, March 20 |
| Former Indian Gee Walker dies in Whitfield, MS at the age of 74. |
| Thursday, April 9 |
| » Major-league debuts: Dave Henderson (Mariners) Tom Brunansky (Angels) |
| Saturday, April 11 |
| » Lost to Brewers (1-0), 5-3 | Cleveland Stadium (0-1) | 0-1 | |
| » W: Mike Caldwell (1-0) L: Bert Blyleven (0-1) S: Rollie Fingers (1) | Third | 1½ out |
| » Major-league debuts: Marshall Edwards (Brewers) |
| Sunday, April 12 |
| » Lost to Brewers (2-0), 6-1 | Cleveland Stadium (0-2) | 0-2 | Lost 2 |
| » W: Jim Slaton (1-0) L: John Denny (0-1) S: Jamie Easterly (1) | Fifth | 2 out |
| » Major-league debuts: Larry Littleton (Indians) |
| Tuesday, April 14 |
| » Defeated Rangers (1-3), 7-1 | Arlington Stadium (1-0) | 1-2 | |
| » W: Rick Waits (1-0) L: Jon Matlack (0-2) | Fourth | 1½ out |
| » Major-league debuts: Von Hayes (Indians) |
| Wednesday, April 15 |
| » Lost to Rangers (2-3), 8-0 | Arlington Stadium (1-1) | 1-3 | |
| » W: Doc Medich (1-0) L: Len Barker (0-1) | Fifth | 2½ out |
| Thursday, April 16 |
| » Defeated Brewers (2-3), 1-0 | County Stadium (1-0) | 2-3 | |
| » W: Wayne Garland (1-0) L: Mike Caldwell (1-1) | Fourth | 2½ out |
| Saturday, April 18 |
| » Defeated Brewers (2-4), 5-0 | County Stadium (2-0) | 3-3 | Won 2 |
| » W: Bert Blyleven (1-1) L: Jim Slaton (1-1) | Fourth | 3 out |
| Monday, April 20 |
| » Defeated Royals (2-5), 4-2 | Royals Stadium (1-0) | 4-3 | Won 3 |
| » W: John Denny (1-1) L: Paul Splittorff (0-1) S: Dan Spillner (1) | Third | 1½ out |
| Tuesday, April 21 |
| » Defeated Royals (2-6), 4-1 | Royals Stadium (2-0) | 5-3 | Won 4 |
| » W: Rick Waits (2-0) L: Juan Berenguer (0-1) | Third | ½ out |
| Wednesday, April 22 |
| » Defeated Royals (2-7), 4-0 | Royals Stadium (3-0) | 6-3 | Won 5 |
| » W: Len Barker (1-1) L: Dennis Leonard (1-2) | First | -- |
| » Major-league debuts: Jim Wright (Royals) |
| Saturday, April 25 |
| » Lost to Rangers (6-6), 8-4 | Cleveland Stadium (0-3) | 6-4 | |
| » W: Rick Honeycutt (1-0) L: Wayne Garland (1-1) S: Steve Comer (1) | Second | 1½ out |
| Sunday, April 26 |
| » Defeated Rangers (6-7), 4-3 | Cleveland Stadium (1-3) | 7-4 | |
| » W: Bert Blyleven (2-1) L: John Henry Johnson (0-1) | First | -- |
| Thursday, April 30 |
| » Defeated White Sox (11-6), 3-2 | Cleveland Stadium (2-3) | 8-4 | Won 2 |
| » W: Rick Waits (3-0) L: Ross Baumgarten (2-2) | First | -- |
| Friday, May 1 |
| » Defeated White Sox (11-7), 10-2 | Cleveland Stadium (3-3) | 9-4 | Won 3 |
| » W: John Denny (2-1) L: Britt Burns (2-1) | First | -- |
| Saturday, May 2 |
| » Defeated White Sox (11-8), 3-1 | Cleveland Stadium (4-3) | 10-4 | Won 4 |
| » W: Len Barker (2-1) L: Francisco Barrios (1-2) | First | -- |
| Sunday, May 3 |
| » Lost to White Sox (12-8), 6-0 | Cleveland Stadium (4-4) | 10-5 | |
| » W: Richard Dotson (3-1) L: Wayne Garland (1-2) | First | -- |
| Wednesday, May 6 |
| » Defeated Blue Jays (8-15), 4-1 | Exhibition Stadium (1-0) | 11-5 | |
| » W: Bert Blyleven (3-1) L: Jackson Todd (1-3) | First | -- |
| Thursday, May 7 |
| » Lost to Blue Jays (9-15), 6-2 | Exhibition Stadium (1-1) | 11-6 | |
| » W: Dave Stieb (2-3) L: Rick Waits (3-1) | First | -- |
| Friday, May 8 |
| » Lost to Twins (10-15), 8-7 | Metropolitan Stadium (0-1) | 11-7 | Lost 2 |
| » W: Jack O'Connor (1-1) L: Sid Monge (0-1) | First | -- |
| Former Indian Eddie Onslow dies in Dennison, OH at the age of 89. |
| Saturday, May 9 |
| » Defeated Twins (10-16), 2-1 | Metropolitan Stadium (1-1) | 12-7 | |
| » W: Sid Monge (1-1) L: Pete Redfern (3-2) | First | -- |
| Sunday, May 10 |
| » Defeated Twins (10-17), 5-1 | Metropolitan Stadium (2-1) | 13-7 | Won 2 |
| » W: Wayne Garland (2-2) L: Jerry Koosman (1-5) | First | -- |
| Monday, May 11 |
| » Defeated White Sox (14-12), 3-1 | Comiskey Park I (1-0) | 14-7 | Won 3 |
| » W: Bert Blyleven (4-1) L: Ross Baumgarten (2-4) | First | -- |
| Tuesday, May 12 |
| » Lost to White Sox (15-12), 7-4 | Comiskey Park I (1-1) | 14-8 | |
| » W: Steve Trout (2-1) L: Rick Waits (3-2) S: La Marr Hoyt (4) | First | -- |
| Wednesday, May 13 |
| » Defeated White Sox (15-13), 4-3 | Comiskey Park I (2-1) | 15-8 | |
| » W: Mike Stanton (1-0) L: Dennis Lamp (1-1) | First | -- |
| Friday, May 15 |
| » Defeated Blue Jays (10-22), 3-0 | Cleveland Stadium (5-4) | 16-8 | Won 2 |
| » W: Len Barker (3-1) L: Luis Leal (2-4) | First | -- |
| Saturday, May 16 |
| » Lost to Blue Jays (11-22), 4-1 | Cleveland Stadium (5-5) | 16-9 | |
| » W: Jackson Todd (2-3) L: Wayne Garland (2-3) | First | -- |
| Sunday, May 17 |
| » Defeated Blue Jays (11-23), 1-0 | Cleveland Stadium (6-5) | 17-9 | |
| » W: Rick Waits (4-2) L: Dave Stieb (3-4) S: Sid Monge (1) | First | -- |
| » Defeated Blue Jays (11-24), 2-1 | Cleveland Stadium (7-5) | 18-9 | Won 2 |
| » W: Bert Blyleven (5-1) L: Roy Lee Jackson (0-2) | First | -- |
| Monday, May 18 |
| » Lost to Angels (20-18), 7-2 | Cleveland Stadium (7-6) | 18-10 | |
| » W: Steve Renko (3-2) L: John Denny (2-2) S: Andy Hassler (2) | Second | 1½ out |
| Tuesday, May 19 |
| » Defeated Angels (20-19), 7-3 | Cleveland Stadium (8-6) | 19-10 | |
| » W: Dan Spillner (1-0) L: Geoff Zahn (5-4) | Second | 1½ out |
| Wednesday, May 20 |
| » Lost to Mariners (12-24), 3-1 | Cleveland Stadium (8-7) | 19-11 | |
| » W: Brian Allard (1-1) L: Len Barker (3-2) S: Shane Rawley (2) | Second | 1½ out |
| Thursday, May 21 |
| » Lost to Mariners (13-24), 6-3 | Cleveland Stadium (8-8) | 19-12 | Lost 2 |
| » W: Glenn Abbott (1-4) L: Wayne Garland (2-4) S: Larry Andersen (1) | Second | 1½ out |
| Friday, May 22 |
| » Defeated Yankees (22-15), 7-3 | Yankee Stadium (1-0) | 20-12 | |
| » W: Bert Blyleven (6-1) L: Tommy John (5-4) | Second | 1½ out |
| Former Indian Bill Bayne dies in St.Louis, MO at the age of 83. |
| Saturday, May 23 |
| » Lost to Yankees (23-15), 3-2 | Yankee Stadium (1-1) | 20-13 | |
| » W: Dave Righetti (1-0) L: Rick Waits (4-3) S: Ron Davis (4) | Second | 2½ out |
| Former Indian Gene Green dies in St.Louis, MO at the age of 48. |
| Sunday, May 24 |
| » Defeated Yankees (23-16), 12-5 | Yankee Stadium (2-1) | 21-13 | |
| » W: John Denny (3-2) L: Rudy May (4-3) | Second | 2 out |
| Monday, May 25 |
| » Lost to Red Sox (23-18), 8-7 | Fenway Park (0-1) | 21-14 | |
| » W: Mark Clear (5-0) L: Sid Monge (1-2) | Second | 2 out |
| Tuesday, May 26 |
| » Defeated Red Sox (23-19), 5-2 | Fenway Park (1-1) | 22-14 | |
| » W: Wayne Garland (3-4) L: Dennis Eckersley (4-4) S: Dan Spillner (2) | Second | 2 out |
| Wednesday, May 27 |
| » Lost to Red Sox (24-19), 10-5 | Fenway Park (1-2) | 22-15 | |
| » W: Mark Clear (6-0) L: Bert Blyleven (6-2) | Second | 3 out |
| Friday, May 29 |
| » Lost to Yankees (24-19), 5-2 | Cleveland Stadium (8-9) | 22-16 | Lost 2 |
| » W: Dave Righetti (2-0) L: Rick Waits (4-4) S: Rich Gossage (12) | Third | 4 out |
| Saturday, May 30 |
| » Lost to Yankees (25-19), 1-0 | Cleveland Stadium (8-10) | 22-17 | Lost 3 |
| » W: Gene Nelson (2-1) L: Dan Spillner (1-1) S: Rich Gossage (13) | Fourth | 4 out |
| Sunday, May 31 |
| » Defeated Yankees (25-20), 7-2 | Cleveland Stadium (9-10) | 23-17 | |
| » W: Len Barker (4-2) L: Rudy May (4-4) | Third | 3 out |
| Monday, June 1 |
| » Lost to Yankees (26-20), 5-3 | Cleveland Stadium (9-11) | 23-18 | |
| » W: Doug Bird (4-0) L: Wayne Garland (3-5) S: Rich Gossage (14) | Fourth | 3½ out |
| Tuesday, June 2 |
| » Lost to Red Sox (26-21), 4-0 | Cleveland Stadium (9-12) | 23-19 | Lost 2 |
| » W: Dennis Eckersley (5-4) L: Bert Blyleven (6-3) | Fifth | 3½ out |
| Wednesday, June 3 |
| » Defeated Red Sox (26-22), 4-1 | Cleveland Stadium (10-12) | 24-19 | |
| » W: Rick Waits (5-4) L: John Tudor (2-2) S: Sid Monge (2) | Fourth | 2½ out |
| Thursday, June 4 |
| » Lost to Red Sox (27-22), 6-5 | Cleveland Stadium (10-13) | 24-20 | |
| » W: Mike Torrez (5-2) L: Dan Spillner (1-2) S: Tom Burgmeier (6) | Fifth | 2½ out |
| Friday, June 5 |
| » Defeated Mariners (18-33), 8-1 | Kingdome (1-0) | 25-20 | |
| » W: Len Barker (5-2) L: Mike Parrott (1-5) | Fifth | 2½ out |
| Saturday, June 6 |
| » Defeated Mariners (18-34), 5-3 | Kingdome (2-0) | 26-20 | Won 2 |
| » W: Bert Blyleven (7-3) L: Shane Rawley (0-3) S: Mike Stanton (1) | Fourth | 2½ out |
| Sunday, June 7 |
| » Lost to Mariners (19-34), 5-4 | Kingdome (2-1) | 26-21 | |
| » W: Dick Drago (3-2) L: Mike Stanton (1-1) | Fourth | 3½ out |
| Monday, June 8 |
| » Lost to Angels (28-29), 10-2 | Anaheim Stadium (0-1) | 26-22 | Lost 2 |
| » W: Geoff Zahn (7-6) L: Dan Spillner (1-3) | Fourth | 4½ out |
| Tuesday, June 9 |
| » Lost to Angels (29-29), 4-2 | Anaheim Stadium (0-2) | 26-23 | Lost 3 |
| » W: Andy Hassler (3-1) L: Len Barker (5-3) S: Don Aase (5) | Fifth | 5½ out |
| Wednesday, June 10 |
| » Lost to Angels (30-29), 4-3 | Anaheim Stadium (0-3) | 26-24 | Lost 4 |
| » W: Steve Renko (4-3) L: Bert Blyleven (7-4) S: Don Aase (6) | Fifth | 5½ out |
| Sunday, June 28 |
| Future Indian Brandon Phillips is born in Raleigh, NC. |
| Saturday, July 4 |
| Future Indian Francisco Cruceta is born in La Vega, D.R. |
| Wednesday, July 8 |
| Former Indian Merl Combs dies in Riverside, CA at the age of 62. |
| Monday, August 10 |
| » Lost to Brewers (32-25), 5-2 | Cleveland Stadium (10-14) | 26-25 | Lost 5 |
| » W: Rickey Keeton (1-0) L: Mike Stanton (1-2) | Sixth | 6 out |
| Tuesday, August 11 |
| » Lost to Brewers (33-25), 6-5 | Cleveland Stadium (10-15) | 26-26 | Lost 6 |
| » W: Mike Caldwell (7-5) L: John Denny (3-3) S: Jamie Easterly (3) | Sixth | 6½ out |
| » Lost to Brewers (34-25), 6-1 | Cleveland Stadium (10-16) | 26-27 | Lost 7 |
| » W: Jim Slaton (4-4) L: Rick Waits (5-5) S: Jerry Augustine (2) | Sixth | 6½ out |
| Wednesday, August 12 |
| » Defeated Brewers (34-26), 9-4 | Cleveland Stadium (11-16) | 27-27 | |
| » W: Len Barker (6-3) L: Randy Lerch (3-6) | Sixth | 6½ out |
| Thursday, August 13 |
| » Lost to Brewers (35-26), 8-5 | Cleveland Stadium (11-17) | 27-28 | |
| » W: Moose Haas (6-4) L: Wayne Garland (3-6) S: Rollie Fingers (13) | Sixth | 7½ out |
| » Major-league debuts: Chris Bando (Indians) |
| Friday, August 14 |
| » Lost to Royals (22-33), 4-1 | Cleveland Stadium (11-18) | 27-29 | Lost 2 |
| » W: Mike Jones (1-0) L: Bert Blyleven (7-5) S: Renie Martin (4) | Sixth | 7½ out |
| Saturday, August 15 |
| » Lost to Royals (23-33), 5-3 | Cleveland Stadium (11-19) | 27-30 | Lost 3 |
| » W: Dennis Leonard (7-7) L: John Denny (3-4) S: Dan Quisenberry (10) | Sixth | 7½ out |
| Sunday, August 16 |
| » Lost to Royals (24-33), 6-2 | Cleveland Stadium (11-20) | 27-31 | Lost 4 |
| » W: Larry Gura (6-5) L: Rick Waits (5-6) S: Ken Brett (2) | Sixth | 7 out |
| » Defeated Royals (24-34), 8-6 | Cleveland Stadium (12-20) | 28-31 | |
| » W: Mike Stanton (2-2) L: Renie Martin (2-5) S: Sid Monge (3) | Sixth | 7 out |
| Tuesday, August 18 |
| » Defeated Mariners (27-39), 5-2 | Kingdome (3-1) | 29-31 | Won 2 |
| » W: Bert Blyleven (8-5) L: Bryan Clark (2-3) S: Dan Spillner (3) | Sixth | 6½ out |
| Wednesday, August 19 |
| » Lost to Mariners (28-39), 4-3 | Kingdome (3-2) | 29-32 | |
| » W: Shane Rawley (2-3) L: Sid Monge (1-3) | Sixth | 6½ out |
| Thursday, August 20 |
| » Defeated Mariners (28-40), 6-5 | Kingdome (4-2) | 30-32 | |
| » W: Mike Stanton (3-2) L: Dick Drago (4-4) | Sixth | 6 out |
| Friday, August 21 |
| » Lost to Angels (35-35), 12-2 | Anaheim Stadium (0-4) | 30-33 | |
| » W: Ken Forsch (10-5) L: Len Barker (6-4) | Sixth | 6½ out |
| Saturday, August 22 |
| » Lost to Angels (36-35), 3-2 | Anaheim Stadium (0-5) | 30-34 | Lost 2 |
| » W: Don Aase (3-3) L: Sid Monge (1-4) | Sixth | 7½ out |
| Sunday, August 23 |
| » Defeated Angels (36-36), 6-3 | Anaheim Stadium (1-5) | 31-34 | |
| » W: John Denny (4-4) L: Dave Frost (1-3) S: Mike Stanton (2) | Sixth | 7½ out |
| Monday, August 24 |
| » Lost to Athletics (45-28), 16-4 | Oakland-Alameda County Stadium (0-1) | 31-35 | |
| » W: Matt Keough (8-3) L: Rick Waits (5-7) | Sixth | 7½ out |
| Tuesday, August 25 |
| » Defeated Athletics (45-29), 2-0 | Oakland-Alameda County Stadium (1-1) | 32-35 | |
| » W: Len Barker (7-4) L: Steve McCatty (8-6) | Sixth | 7½ out |
| Thursday, August 27 |
| » Defeated Mariners (28-46), 12-2 | Cleveland Stadium (13-20) | 33-35 | Won 2 |
| » W: Bert Blyleven (9-5) L: Mike Parrott (3-6) | Sixth | 7 out |
| Friday, August 28 |
| » Defeated Mariners (28-47), 1-0 | Cleveland Stadium (14-20) | 34-35 | Won 3 |
| » W: John Denny (5-4) L: Shane Rawley (2-4) | Fifth | 6 out |
| Saturday, August 29 |
| » Defeated Mariners (28-48), 7-3 | Cleveland Stadium (15-20) | 35-35 | Won 4 |
| » W: Rick Waits (6-7) L: Floyd Bannister (6-6) | Fifth | 6 out |
| Sunday, August 30 |
| » Defeated Mariners (28-49), 17-11 | Cleveland Stadium (16-20) | 36-35 | Won 5 |
| » W: Sid Monge (2-4) L: Shane Rawley (2-5) | Fifth | 5½ out |
| Monday, August 31 |
| » Lost to Athletics (47-32), 5-3 | Cleveland Stadium (16-21) | 36-36 | |
| » W: Rick Langford (8-8) L: Bert Blyleven (9-6) S: Tom Underwood (1) | Fifth | 6½ out |
| Wednesday, September 2 |
| » Defeated Athletics (47-33), 2-0 | Cleveland Stadium (17-21) | 37-36 | |
| » W: John Denny (6-4) L: Mike Norris (9-6) | Sixth | 5½ out |
| » Defeated Athletics (47-34), 10-4 | Cleveland Stadium (18-21) | 38-36 | Won 2 |
| » W: Dan Spillner (2-3) L: Matt Keough (8-5) | Sixth | 5½ out |
| Thursday, September 3 |
| » Major-league debuts: Neil Fiala and Gene Roof (Cardinals) |
| Friday, September 4 |
| » Lost to Angels (42-40), 3-1 | Cleveland Stadium (18-22) | 38-37 | |
| » W: Geoff Zahn (9-7) L: Len Barker (7-5) | Sixth | 6 out |
| Saturday, September 5 |
| » Defeated Angels (42-41), 4-2 | Cleveland Stadium (19-22) | 39-37 | |
| » W: Bert Blyleven (10-6) L: Steve Renko (5-4) | Sixth | 5½ out |
| » Defeated Angels (42-42), 4-2 | Cleveland Stadium (20-22) | 40-37 | Won 2 |
| » W: Tom Brennan (1-0) L: Dave Frost (1-5) S: Dan Spillner (4) | Sixth | 5½ out |
| » Major-league debuts: Tom Brennan (Indians) |
| Sunday, September 6 |
| » Defeated Angels (42-43), 2-0 | Cleveland Stadium (21-22) | 41-37 | Won 3 |
| » W: John Denny (7-4) L: Ken Forsch (11-7) | Sixth | 5½ out |
| Monday, September 7 |
| » Lost to Orioles (47-34), 9-2 | Memorial Stadium (0-1) | 41-38 | |
| » W: Jim Palmer (5-7) L: Rick Waits (6-8) | Sixth | 6½ out |
| Tuesday, September 8 |
| » Lost to Orioles (48-34), 14-5 | Memorial Stadium (0-2) | 41-39 | Lost 2 |
| » W: Scott McGregor (10-3) L: Len Barker (7-6) | Sixth | 7 out |
| Wednesday, September 9 |
| » Defeated Orioles (48-35), 8-5 | Memorial Stadium (1-2) | 42-39 | |
| » W: Bert Blyleven (11-6) L: Steve Stone (4-5) | Sixth | 6½ out |
| Thursday, September 10 |
| » Defeated Orioles (48-36), 4-1 | Memorial Stadium (2-2) | 43-39 | Won 2 |
| » W: John Denny (8-4) L: Sammy Stewart (3-6) S: Dan Spillner (5) | Sixth | 6 out |
| Friday, September 11 |
| » Lost to Tigers (51-37), 6-3 | Tiger Stadium (0-1) | 43-40 | |
| » W: Dan Schatzeder (6-7) L: Rick Waits (6-9) | Sixth | 7 out |
| » Major-league debuts: Larry Rothschild (Tigers) |
| Saturday, September 12 |
| » Lost to Tigers (52-37), 11-9 | Tiger Stadium (0-2) | 43-41 | Lost 2 |
| » W: Dave Rozema (5-5) L: Sid Monge (2-5) | Sixth | 7 out |
| Sunday, September 13 |
| » Lost to Tigers (53-37), 8-6 | Tiger Stadium (0-3) | 43-42 | Lost 3 |
| » W: Milt Wilcox (10-7) L: Dan Spillner (2-4) S: Larry Rothschild (1) | Sixth | 8 out |
| Tuesday, September 15 |
| » Lost to Orioles (50-38), 7-6 | Cleveland Stadium (21-23) | 43-43 | Lost 4 |
| » W: Dennis Martinez (13-4) L: Mike Stanton (3-3) | Sixth | 8½ out |
| » Major-league debuts: John Shelby (Orioles) |
| Thursday, September 17 |
| » Lost to Orioles (51-38), 6-2 | Cleveland Stadium (21-24) | 43-44 | Lost 5 |
| » W: Scott McGregor (11-3) L: Len Barker (7-7) S: Tim Stoddard (6) | Fifth | 8½ out |
| Friday, September 18 |
| » Defeated Tigers (53-42), 8-4 | Cleveland Stadium (22-24) | 44-44 | |
| » W: John Denny (9-4) L: Dan Schatzeder (6-8) S: Dan Spillner (6) | Sixth | 8½ out |
| Saturday, September 19 |
| » Lost to Tigers (54-42), 4-3 | Cleveland Stadium (22-25) | 44-45 | |
| » W: Dan Petry (9-7) L: Bert Blyleven (11-7) S: George Cappuzzello (1) | Sixth | 8½ out |
| Sunday, September 20 |
| » Lost to Tigers (55-42), 5-1 | Cleveland Stadium (22-26) | 44-46 | Lost 2 |
| » W: Jack Morris (13-5) L: Tom Brennan (1-1) | Fifth | 8½ out |
| Monday, September 21 |
| » Defeated Yankees (55-41), 5-0 | Yankee Stadium (3-1) | 45-46 | |
| » W: Rick Waits (7-9) L: Rudy May (6-11) | Sixth | 7½ out |
| Tuesday, September 22 |
| » Defeated Yankees (55-42), 6-4 | Yankee Stadium (4-1) | 46-46 | Won 2 |
| » W: Len Barker (8-7) L: Dave Righetti (6-4) S: Sid Monge (4) | Sixth | 7½ out |
| » Major-league debuts: Andy McGaffigan (Yankees) |
| Wednesday, September 23 |
| » Lost to Yankees (56-42), 6-1 | Yankee Stadium (4-2) | 46-47 | |
| » W: Rick Reuschel (8-9) L: John Denny (9-5) | Sixth | 7½ out |
| Thursday, September 24 |
| » Defeated Red Sox (55-44), 5-2 | Fenway Park (2-2) | 47-47 | |
| » W: Dan Spillner (3-4) L: Mike Torrez (8-3) | Sixth | 7 out |
| Friday, September 25 |
| » Lost to Red Sox (56-44), 5-4 | Fenway Park (2-3) | 47-48 | |
| » W: Bob Stanley (10-7) L: Wayne Garland (3-7) | Fourth | 7 out |
| Saturday, September 26 |
| » Defeated Red Sox (56-45), 7-5 | Fenway Park (3-3) | 48-48 | |
| » W: Rick Waits (8-9) L: Dennis Eckersley (9-7) S: Dan Spillner (7) | Sixth | 7 out |
| Sunday, September 27 |
| » Defeated Red Sox (56-46), 8-7 | Fenway Park (4-3) | 49-48 | Won 2 |
| » W: Sid Monge (3-5) L: Mark Clear (8-3) | Fifth | 6½ out |
| Monday, September 28 |
| » Defeated Yankees (58-45), 6-2 | Cleveland Stadium (23-26) | 50-48 | Won 3 |
| » W: Tom Brennan (2-1) L: Rick Reuschel (8-10) | Sixth | 6 out |
| Tuesday, September 29 |
| » Defeated Yankees (58-46), 3-2 | Cleveland Stadium (24-26) | 51-48 | Won 4 |
| » W: John Denny (10-5) L: Ron Guidry (11-5) | Fifth | 5 out |
| Friday, October 2 |
| » Defeated Red Sox (57-49), 11-4 | Cleveland Stadium (25-26) | 52-48 | Won 5 |
| » W: Dan Spillner (4-4) L: Dennis Eckersley (9-8) | Sixth | 5½ out |
| Saturday, October 3 |
| » Lost to Red Sox (58-49), 4-0 | Cleveland Stadium (25-27) | 52-49 | |
| » W: Frank Tanana (4-10) L: Tom Brennan (2-2) | Sixth | 6½ out |
| Sunday, October 4 |
| » Lost to Red Sox (59-49), 6-2 | Cleveland Stadium (25-28) | 52-50 | Lost 2 |
| » W: Mike Torrez (10-3) L: John Denny (10-6) S: Luis Aponte (1) | Sixth | 6½ out |
| Monday, October 5 |
| » Lost to Royals (50-53), 9-0 | Cleveland Stadium (25-29) | 52-51 | Lost 3 |
| » W: Paul Splittorff (5-5) L: Rick Waits (8-10) | Sixth | 7 out |
| Sunday, October 25 |
| Former Indian Pete Reiser dies in Palm Springs, CA at the age of 63. |
| Monday, November 16 |
| Future Indian Fernando Cabrera is born in Toja Baja, P.R. |
| Wednesday, December 30 |
| Former Indian Josh Billings dies in Santa Monica, CA at the age of 90. |
Game information provided by Retrosheet (www.retrosheet.org) |