| Tuesday, March 17 |
| Former Giant Paul Dean dies in Springdale, AR at the age of 68. |
| Thursday, April 9 |
| » Lost to Padres (1-0), 4-1 | Candlestick Park (0-1) | 0-1 | |
| » W: Gary Lucas (1-0) L: Al Holland (0-1) S: John Littlefield (1) | Third | 1 out |
| » Major-league debuts: Juan Bonilla (Padres) |
| Friday, April 10 |
| » Lost to Padres (2-0), 4-2 | Candlestick Park (0-2) | 0-2 | Lost 2 |
| » W: John Urrea (1-0) L: Gary Lavelle (0-1) S: John Littlefield (2) | Fifth | 2 out |
| » Major-league debuts: Chili Davis (Giants) |
| Saturday, April 11 |
| » Defeated Padres (2-1), 2-0 | Candlestick Park (1-2) | 1-2 | |
| » W: Doyle Alexander (1-0) L: Juan Eichelberger (0-1) S: Greg Minton (1) | Fourth | 1½ out |
| Sunday, April 12 |
| » Defeated Padres (2-2), 7-6 | Candlestick Park (2-2) | 2-2 | Won 2 |
| » W: Fred Breining (1-0) L: Gary Lucas (1-1) | Third | 1½ out |
| » Major-league debuts: Chris Welsh (Padres) |
| Monday, April 13 |
| » Lost to Dodgers (4-0), 4-3 | Candlestick Park (2-3) | 2-3 | |
| » W: Dave Stewart (1-0) L: Allen Ripley (0-1) S: Bobby Castillo (1) | Fourth | 2½ out |
| Tuesday, April 14 |
| » Lost to Dodgers (5-0), 7-1 | Candlestick Park (2-4) | 2-4 | Lost 2 |
| » W: Fernando Valenzuela (2-0) L: Vida Blue (0-1) | Fourth | 3½ out |
| Wednesday, April 15 |
| » Lost to Dodgers (6-0), 4-2 | Candlestick Park (2-5) | 2-5 | Lost 3 |
| » W: Burt Hooton (2-0) L: Ed Whitson (0-1) S: Bobby Castillo (2) | Fifth | 4½ out |
| Friday, April 17 |
| » Defeated Braves (3-4), 6-2 | Atlanta-Fulton County Stadium (1-0) | 3-5 | |
| » W: Doyle Alexander (2-0) L: Gaylord Perry (0-1) | Fourth | 3½ out |
| Saturday, April 18 |
| » Defeated Braves (3-5), 4-1 | Atlanta-Fulton County Stadium (2-0) | 4-5 | Won 2 |
| » W: Tom Griffin (1-0) L: John Montefusco (0-1) | Third | 3½ out |
| Sunday, April 19 |
| » Lost to Braves (4-5), 4-3 | Atlanta-Fulton County Stadium (2-1) | 4-6 | |
| » W: Rick Camp (2-0) L: Greg Minton (0-1) | Fourth | 4½ out |
| Monday, April 20 |
| » Defeated Padres (3-8), 9-0 | San Diego/Jack Murphy Stadium (1-0) | 5-6 | |
| » W: Vida Blue (1-1) L: Steve Mura (0-2) S: Gary Lavelle (1) | Third | 4½ out |
| Tuesday, April 21 |
| » Lost to Padres (4-8), 3-1 | San Diego/Jack Murphy Stadium (1-1) | 5-7 | |
| » W: Chris Welsh (1-0) L: Doyle Alexander (2-1) S: Gary Lucas (1) | Third | 4½ out |
| Wednesday, April 22 |
| » Lost to Padres (5-8), 4-0 | San Diego/Jack Murphy Stadium (1-2) | 5-8 | Lost 2 |
| » W: Juan Eichelberger (1-1) L: Ed Whitson (0-2) S: Gary Lucas (2) | Fourth | 5½ out |
| Thursday, April 23 |
| » Lost to Braves (7-5), 7-3 | Candlestick Park (2-6) | 5-9 | Lost 3 |
| » W: John Montefusco (1-1) L: Tom Griffin (1-1) S: Rick Camp (2) | Fourth | 6½ out |
| Friday, April 24 |
| » Lost to Braves (8-5), 7-1 | Candlestick Park (2-7) | 5-10 | Lost 4 |
| » W: Bob Walk (1-1) L: Allen Ripley (0-2) | Fifth | 6½ out |
| Saturday, April 25 |
| » Lost to Braves (9-5), 4-0 | Candlestick Park (2-8) | 5-11 | Lost 5 |
| » W: Phil Niekro (1-0) L: Vida Blue (1-2) | Fifth | 7½ out |
| Sunday, April 26 |
| » Defeated Braves (9-6), 3-1 | Candlestick Park (3-8) | 6-11 | |
| » W: Doyle Alexander (3-1) L: Gaylord Perry (1-2) S: Greg Minton (2) | Fourth | 7 out |
| » Defeated Braves (9-7), 8-5 | Candlestick Park (4-8) | 7-11 | Won 2 |
| » W: Al Holland (1-1) L: Tommy Boggs (1-2) S: Gary Lavelle (2) | Fourth | 7 out |
| Monday, April 27 |
| » Lost to Dodgers (14-3), 5-0 | Dodger Stadium (0-1) | 7-12 | |
| » W: Fernando Valenzuela (5-0) L: Tom Griffin (1-2) | Fourth | 8 out |
| Tuesday, April 28 |
| » Defeated Dodgers (14-4), 6-1 | Dodger Stadium (1-1) | 8-12 | |
| » W: Allen Ripley (1-2) L: Rick Sutcliffe (2-1) | Fourth | 7 out |
| Wednesday, April 29 |
| » Defeated Dodgers (14-5), 3-2 | Dodger Stadium (2-1) | 9-12 | Won 2 |
| » W: Vida Blue (2-2) L: Bob Welch (1-1) S: Greg Minton (3) | Fourth | 6 out |
| Saturday, May 2 |
| » Defeated Phillies (12-7), 6-2 | Veteran's Stadium (1-0) | 10-12 | Won 3 |
| » W: Doyle Alexander (4-1) L: Nino Espinosa (1-1) S: Greg Minton (4) | Fourth | 6 out |
| » Lost to Phillies (13-7), 3-1 | Veteran's Stadium (1-1) | 10-13 | |
| » W: Marty Bystrom (2-0) L: Ed Whitson (0-3) | Fourth | 6 out |
| Sunday, May 3 |
| » Lost to Phillies (14-7), 7-5 | Veteran's Stadium (1-2) | 10-14 | Lost 2 |
| » W: Dick Ruthven (4-1) L: Gary Lavelle (0-2) S: Tug McGraw (2) | Fourth | 7 out |
| Monday, May 4 |
| » Lost to Phillies (15-7), 6-4 | Veteran's Stadium (1-3) | 10-15 | Lost 3 |
| » W: Steve Carlton (5-0) L: Allen Ripley (1-3) | Fifth | 7 out |
| Tuesday, May 5 |
| » Defeated Mets (6-13), 9-7 | Shea Stadium (1-0) | 11-15 | |
| » W: Tom Griffin (2-2) L: Randy Jones (0-4) S: Greg Minton (5) | Fifth | 6 out |
| Wednesday, May 6 |
| » Defeated Mets (6-14), 6-4 | Shea Stadium (2-0) | 12-15 | Won 2 |
| » W: Greg Minton (1-1) L: Pat Zachry (3-3) | Fourth | 6 out |
| Thursday, May 7 |
| » Lost to Mets (7-14), 3-2 | Shea Stadium (2-1) | 12-16 | |
| » W: Ed Lynch (1-0) L: Doyle Alexander (4-2) S: Neil Allen (4) | Fifth | 7 out |
| Friday, May 8 |
| » Defeated Expos (16-8), 4-3 | Stade Olympique (1-0) | 13-16 | |
| » W: Allen Ripley (2-3) L: Bill Gullickson (1-3) S: Al Holland (1) | Fourth | 7 out |
| Saturday, May 9 |
| » Defeated Expos (16-9), 8-2 | Stade Olympique (2-0) | 14-16 | Won 2 |
| » W: Vida Blue (3-2) L: Steve Rogers (3-2) | Fourth | 6 out |
| Sunday, May 10 |
| » Defeated Expos (16-10), 5-1 | Stade Olympique (3-0) | 15-16 | Won 3 |
| » W: Tom Griffin (3-2) L: Bill Lee (1-1) | Fourth | 6½ out |
| » Lost to Expos (17-10), 4-0 | Stade Olympique (3-1) | 15-17 | |
| » W: Charlie Lea (1-1) L: Ed Whitson (0-4) | Fourth | 6½ out |
| Tuesday, May 12 |
| » Defeated Phillies (18-11), 4-0 | Candlestick Park (5-8) | 16-17 | |
| » W: Doyle Alexander (5-2) L: Nino Espinosa (1-3) | Fourth | 6½ out |
| Wednesday, May 13 |
| » Defeated Phillies (18-12), 5-2 | Candlestick Park (6-8) | 17-17 | Won 2 |
| » W: Allen Ripley (3-3) L: Marty Bystrom (2-2) S: Greg Minton (6) | Fourth | 6½ out |
| Thursday, May 14 |
| » Lost to Phillies (19-12), 3-1 | Candlestick Park (6-9) | 17-18 | |
| » W: Dick Ruthven (5-1) L: Vida Blue (3-3) S: Tug McGraw (3) | Third | 7½ out |
| Friday, May 15 |
| » Defeated Expos (17-14), 4-2 | Candlestick Park (7-9) | 18-18 | |
| » W: Ed Whitson (1-4) L: Steve Rogers (3-3) S: Gary Lavelle (3) | Third | 7½ out |
| Saturday, May 16 |
| » Lost to Expos (18-14), 5-0 | Candlestick Park (7-10) | 18-19 | |
| » W: Charlie Lea (2-1) L: Tom Griffin (3-3) | Fifth | 8½ out |
| Former Giant Jim Finigan dies in Quincy, IL at the age of 53. |
| Sunday, May 17 |
| » Defeated Expos (18-15), 5-4 | Candlestick Park (8-10) | 19-19 | |
| » W: Al Holland (2-1) L: Bill Lee (1-2) | Fifth | 8½ out |
| Monday, May 18 |
| » Defeated Mets (8-23), 3-1 | Candlestick Park (9-10) | 20-19 | Won 2 |
| » W: Allen Ripley (4-3) L: Ed Lynch (1-2) S: Greg Minton (7) | Fourth | 7½ out |
| Tuesday, May 19 |
| » Defeated Mets (8-24), 4-1 | Candlestick Park (10-10) | 21-19 | Won 3 |
| » W: Al Holland (3-1) L: Mike Scott (1-4) S: Greg Minton (8) | Third | 6½ out |
| Wednesday, May 20 |
| » Lost to Mets (9-24), 4-3 | Candlestick Park (10-11) | 21-20 | |
| » W: Jeff Reardon (1-0) L: Greg Minton (1-2) | Third | 7½ out |
| » Major-league debuts: Greg Harris (Mets) |
| Friday, May 22 |
| » Defeated Astros (19-21), 6-3 | Astrodome (1-0) | 22-20 | |
| » W: Greg Minton (2-2) L: Joaquin Andujar (1-3) | Third | 7½ out |
| Saturday, May 23 |
| » Lost to Astros (20-21), 5-3 | Astrodome (1-1) | 22-21 | |
| » W: Frank LaCorte (2-1) L: Ed Whitson (1-5) | Third | 8½ out |
| Sunday, May 24 |
| » Defeated Astros (20-22), 2-1 | Astrodome (2-1) | 23-21 | |
| » W: Vida Blue (4-3) L: Don Sutton (3-5) S: Greg Minton (9) | Third | 8 out |
| Monday, May 25 |
| » Lost to Reds (24-18), 6-3 | Riverfront Stadium (0-1) | 23-22 | |
| » W: Geoff Combe (1-0) L: Al Holland (3-2) | Third | 9 out |
| Wednesday, May 27 |
| » Lost to Reds (25-18), 3-2 | Riverfront Stadium (0-2) | 23-23 | Lost 2 |
| » W: Mario Soto (4-5) L: Doyle Alexander (5-3) | Fourth | 9 out |
| Thursday, May 28 |
| » Lost to Reds (26-18), 7-4 | Riverfront Stadium (0-3) | 23-24 | Lost 3 |
| » W: Joe Price (4-0) L: Gary Lavelle (0-3) | Fifth | 9 out |
| Friday, May 29 |
| » Defeated Astros (23-23), 3-1 | Candlestick Park (11-11) | 24-24 | |
| » W: Vida Blue (5-3) L: Don Sutton (3-6) S: Al Holland (2) | Fifth | 9 out |
| Saturday, May 30 |
| » Lost to Astros (24-23), 9-8 | Candlestick Park (11-12) | 24-25 | |
| » W: Joaquin Andujar (2-3) L: Fred Breining (1-1) S: Vern Ruhle (1) | Fifth | 9 out |
| Sunday, May 31 |
| » Defeated Astros (24-24), 6-1 | Candlestick Park (12-12) | 25-25 | |
| » W: Tom Griffin (4-3) L: Nolan Ryan (4-3) S: Al Holland (3) | Fourth | 9 out |
| Former Giant Mike Smith dies in Chesapeake, VA at the age of 77. |
| Monday, June 1 |
| » Lost to Reds (28-20), 8-5 | Candlestick Park (12-13) | 25-26 | |
| » W: Tom Hume (3-2) L: Greg Minton (2-3) | Fourth | 10 out |
| Tuesday, June 2 |
| » Defeated Reds (28-21), 15-7 | Candlestick Park (13-13) | 26-26 | |
| » W: Ed Whitson (2-5) L: Mike LaCoss (2-6) S: Al Holland (4) | Fourth | 9 out |
| Wednesday, June 3 |
| » Lost to Reds (29-21), 6-2 | Candlestick Park (13-14) | 26-27 | |
| » W: Frank Pastore (3-2) L: Vida Blue (5-4) | Fifth | 9 out |
| Friday, June 5 |
| » Defeated Pirates (23-21), 5-3 | Three Rivers Stadium (1-0) | 27-27 | |
| » W: Fred Breining (2-1) L: Enrique Romo (0-3) S: Gary Lavelle (4) | Fifth | 8 out |
| Saturday, June 6 |
| » Lost to Pirates (24-21), 7-6 | Three Rivers Stadium (1-1) | 27-28 | |
| » W: Rod Scurry (2-2) L: Tom Griffin (4-4) S: Kent Tekulve (1) | Fifth | 8 out |
| Sunday, June 7 |
| » Lost to Pirates (25-21), 3-2 | Three Rivers Stadium (1-2) | 27-29 | Lost 2 |
| » W: Eddie Solomon (5-3) L: Vida Blue (5-5) S: Enrique Romo (8) | Fifth | 9 out |
| Wednesday, June 10 |
| » Lost to Cubs (13-37), 2-1 | Wrigley Field (0-1) | 27-30 | Lost 3 |
| » W: Mike Krukow (3-6) L: Allen Ripley (4-4) S: Dick Tidrow (5) | Fifth | 10 out |
| » Lost to Cubs (14-37), 7-4 | Wrigley Field (0-2) | 27-31 | Lost 4 |
| » W: Rick Reuschel (4-7) L: Doyle Alexander (5-4) S: Dick Tidrow (6) | Fifth | 10 out |
| Thursday, June 11 |
| » Lost to Cubs (15-37), 6-1 | Wrigley Field (0-3) | 27-32 | Lost 5 |
| » W: Randy Martz (3-5) L: Tom Griffin (4-5) | Fifth | 10 out |
| Monday, August 10 |
| » Lost to Astros (29-29), 6-5 | Candlestick Park (13-15) | 27-33 | Lost 6 |
| » W: Joe Sambito (2-3) L: Fred Breining (2-2) S: Frank LaCorte (3) | Fifth | 11 out |
| » Major-league debuts: Bob Tufts (Giants) |
| Tuesday, August 11 |
| » Defeated Astros (29-30), 3-2 | Candlestick Park (14-15) | 28-33 | |
| » W: Tom Griffin (5-5) L: Joe Niekro (6-6) S: Greg Minton (10) | Fifth | 10 out |
| Wednesday, August 12 |
| » Lost to Astros (30-30), 5-4 | Candlestick Park (14-16) | 28-34 | |
| » W: Joe Sambito (3-3) L: Al Holland (3-3) S: Billy Smith (1) | Fifth | 11 out |
| Friday, August 14 |
| » Defeated Reds (36-24), 4-0 | Riverfront Stadium (1-3) | 29-34 | |
| » W: Ed Whitson (3-5) L: Bruce Berenyi (5-3) | Fifth | 11 out |
| » Lost to Reds (37-24), 7-6 | Riverfront Stadium (1-4) | 29-35 | |
| » W: Tom Hume (5-2) L: Al Holland (3-4) | Fifth | 11 out |
| » Major-league debuts: Bob Brenly (Giants) |
| Saturday, August 15 |
| » Defeated Reds (37-25), 5-2 | Riverfront Stadium (2-4) | 30-35 | |
| » W: Doyle Alexander (6-4) L: Frank Pastore (3-4) S: Greg Minton (11) | Fifth | 10 out |
| Sunday, August 16 |
| » Lost to Reds (38-25), 2-1 | Riverfront Stadium (2-5) | 30-36 | |
| » W: Mario Soto (7-6) L: Tom Griffin (5-6) S: Tom Hume (7) | Fifth | 11 out |
| Monday, August 17 |
| » Defeated Pirates (27-29), 5-1 | Three Rivers Stadium (2-2) | 31-36 | |
| » W: Greg Minton (3-3) L: Rod Scurry (2-4) | Fifth | 10 out |
| Tuesday, August 18 |
| » Defeated Pirates (27-30), 4-2 | Three Rivers Stadium (3-2) | 32-36 | Won 2 |
| » W: Ed Whitson (4-5) L: Luis Tiant (0-2) S: Greg Minton (12) | Fifth | 10 out |
| Wednesday, August 19 |
| » Lost to Pirates (28-30), 7-3 | Three Rivers Stadium (3-3) | 32-37 | |
| » W: Odell Jones (1-0) L: Doyle Alexander (6-5) S: Grant Jackson (3) | Fifth | 10 out |
| Thursday, August 20 |
| » Major-league debuts: Brett Butler (Braves) |
| Friday, August 21 |
| » Defeated Cubs (20-43), 4-3 | Wrigley Field (1-3) | 33-37 | |
| » W: Fred Breining (3-2) L: Dick Tidrow (2-6) S: Greg Minton (13) | Fifth | 10 out |
| » Major-league debuts: Pat Tabler (Cubs) |
| Saturday, August 22 |
| » Defeated Cubs (20-44), 2-1 | Wrigley Field (2-3) | 34-37 | Won 2 |
| » W: Vida Blue (6-5) L: Doug Bird (7-2) S: Greg Minton (14) | Fifth | 10 out |
| Sunday, August 23 |
| » Lost to Cubs (21-44), 6-5 | Wrigley Field (2-4) | 34-38 | |
| » W: Doug Capilla (1-0) L: Gary Lavelle (0-4) | Fifth | 10 out |
| Monday, August 24 |
| » Lost to Cardinals (38-24), 2-1 | Busch Stadium II (0-1) | 34-39 | Lost 2 |
| » W: Jim Kaat (5-2) L: Greg Minton (3-4) | Fifth | 11 out |
| Tuesday, August 25 |
| » Defeated Cardinals (38-25), 4-2 | Busch Stadium II (1-1) | 35-39 | |
| » W: Tom Griffin (6-6) L: John Martin (4-2) S: Al Holland (5) | Fifth | 11 out |
| Wednesday, August 26 |
| » Lost to Cardinals (39-25), 9-4 | Busch Stadium II (1-2) | 35-40 | |
| » W: Joaquin Andujar (4-4) L: Gary Lavelle (0-5) S: Bruce Sutter (16) | Fifth | 12 out |
| Thursday, August 27 |
| » Defeated Pirates (31-35), 5-4 | Candlestick Park (15-16) | 36-40 | |
| » W: Al Holland (4-4) L: Don Robinson (0-2) | Fifth | 12 out |
| Friday, August 28 |
| » Defeated Pirates (31-36), 5-1 | Candlestick Park (16-16) | 37-40 | Won 2 |
| » W: Ed Whitson (5-5) L: Rod Scurry (3-5) | Fifth | 12 out |
| Saturday, August 29 |
| » Defeated Pirates (31-37), 8-3 | Candlestick Park (17-16) | 38-40 | Won 3 |
| » W: Doyle Alexander (7-5) L: Luis Tiant (0-3) | Fifth | 11 out |
| Sunday, August 30 |
| » Defeated Pirates (31-38), 5-0 | Candlestick Park (18-16) | 39-40 | Won 4 |
| » W: Tom Griffin (7-6) L: Pascual Perez (2-5) | Fifth | 10 out |
| Monday, August 31 |
| Former Giant Roy Parmelee dies in Monroe, MI at the age of 75. |
| Tuesday, September 1 |
| » Defeated Cardinals (42-27), 4-2 | Candlestick Park (19-16) | 40-40 | Won 5 |
| » W: Vida Blue (7-5) L: Bob Forsch (7-4) S: Al Holland (6) | Fourth | 9½ out |
| Wednesday, September 2 |
| » Lost to Cardinals (43-27), 5-2 | Candlestick Park (19-17) | 40-41 | |
| » W: Lary Sorensen (7-5) L: Ed Whitson (5-6) S: Bruce Sutter (18) | Fifth | 10½ out |
| Thursday, September 3 |
| » Defeated Cubs (26-50), 12-0 | Candlestick Park (20-17) | 41-41 | |
| » W: Doyle Alexander (8-5) L: Doug Bird (8-3) | Fourth | 9½ out |
| » Major-league debuts: Mel Hall (Cubs) |
| Friday, September 4 |
| » Defeated Cubs (26-51), 3-2 | Candlestick Park (21-17) | 42-41 | Won 2 |
| » W: Al Holland (5-4) L: Dick Tidrow (2-8) | Fourth | 8½ out |
| Saturday, September 5 |
| » Lost to Cubs (27-51), 8-2 | Candlestick Park (21-18) | 42-42 | |
| » W: Mike Krukow (5-8) L: Alan Hargesheimer (0-1) | Fourth | 9½ out |
| Sunday, September 6 |
| » Defeated Cubs (27-52), 3-0 | Candlestick Park (22-18) | 43-42 | |
| » W: Vida Blue (8-5) L: Mike Griffin (1-2) S: Greg Minton (15) | Fourth | 9½ out |
| Former Giant Eddie Ainsmith dies in Ft.Lauderdale, FL at the age of 90. |
| Monday, September 7 |
| » Lost to Dodgers (53-32), 5-1 | Dodger Stadium (2-2) | 43-43 | |
| » W: Bob Welch (7-5) L: Ed Whitson (5-7) S: Tom Niedenfuer (2) | Fourth | 10½ out |
| » Major-league debuts: Candy Maldonado and Mike Marshall (Dodgers) |
| Tuesday, September 8 |
| » Lost to Dodgers (54-32), 4-0 | Dodger Stadium (2-3) | 43-44 | Lost 2 |
| » W: Burt Hooton (10-5) L: Doyle Alexander (8-6) S: Dave Stewart (4) | Fourth | 11½ out |
| Wednesday, September 9 |
| » Defeated Dodgers (54-33), 6-3 | Dodger Stadium (3-3) | 44-44 | |
| » W: Al Holland (6-4) L: Tom Niedenfuer (3-1) | Fourth | 10½ out |
| » Major-league debuts: Ted Power (Dodgers) |
| Friday, September 11 |
| » Lost to Astros (48-40), 6-0 | Astrodome (2-2) | 44-45 | |
| » W: Don Sutton (8-8) L: Vida Blue (8-6) | Fifth | 10½ out |
| Saturday, September 12 |
| » Lost to Astros (49-40), 5-2 | Astrodome (2-3) | 44-46 | Lost 2 |
| » W: Joe Niekro (8-7) L: Ed Whitson (5-8) S: Dave Smith (7) | Fifth | 10½ out |
| Sunday, September 13 |
| » Lost to Astros (50-40), 3-0 | Astrodome (2-4) | 44-47 | Lost 3 |
| » W: Bob Knepper (8-3) L: Doyle Alexander (8-7) S: Frank LaCorte (5) | Fifth | 11½ out |
| Monday, September 14 |
| » Defeated Braves (43-44), 4-2 | Candlestick Park (23-18) | 45-47 | |
| » W: Tom Griffin (8-6) L: Tommy Boggs (3-11) S: Greg Minton (16) | Fifth | 11½ out |
| Tuesday, September 15 |
| » Defeated Braves (43-45), 6-5 | Candlestick Park (24-18) | 46-47 | Won 2 |
| » W: Greg Minton (4-4) L: Gene Garber (4-4) | Fourth | 10½ out |
| Wednesday, September 16 |
| » Defeated Reds (54-37), 12-7 | Candlestick Park (25-18) | 47-47 | Won 3 |
| » W: Fred Breining (4-2) L: Mario Soto (8-9) | Fourth | 10½ out |
| Thursday, September 17 |
| » Lost to Reds (55-37), 1-0 | Candlestick Park (25-19) | 47-48 | |
| » W: Tom Seaver (12-2) L: Al Holland (6-5) S: Tom Hume (9) | Fourth | 11½ out |
| Friday, September 18 |
| » Defeated Astros (52-43), 5-2 | Candlestick Park (26-19) | 48-48 | |
| » W: Doyle Alexander (9-7) L: Bob Knepper (8-4) S: Al Holland (7) | Fourth | 10½ out |
| Saturday, September 19 |
| » Lost to Astros (53-43), 8-1 | Candlestick Park (26-20) | 48-49 | |
| » W: Vern Ruhle (4-4) L: Tom Griffin (8-7) | Fourth | 10½ out |
| Sunday, September 20 |
| » Lost to Astros (54-43), 7-3 | Candlestick Park (26-21) | 48-50 | Lost 2 |
| » W: Nolan Ryan (9-5) L: Gary Lavelle (0-6) | Fourth | 11½ out |
| Tuesday, September 22 |
| » Defeated Dodgers (58-40), 5-2 | Candlestick Park (27-21) | 49-50 | |
| » W: Ed Whitson (6-8) L: Fernando Valenzuela (13-5) S: Greg Minton (17) | Fourth | 11 out |
| Wednesday, September 23 |
| » Defeated Dodgers (58-41), 8-4 | Candlestick Park (28-21) | 50-50 | Won 2 |
| » W: Gary Lavelle (1-6) L: Dave Goltz (2-5) S: Fred Breining (1) | Fourth | 11 out |
| Thursday, September 24 |
| » Lost to Dodgers (59-41), 7-3 | Candlestick Park (28-22) | 50-51 | |
| » W: Bob Welch (8-5) L: Tom Griffin (8-8) | Fourth | 11½ out |
| Friday, September 25 |
| » Defeated Padres (36-65), 3-0 | San Diego/Jack Murphy Stadium (2-2) | 51-51 | |
| » W: Al Holland (7-5) L: Steve Fireovid (0-1) S: Greg Minton (18) | Fourth | 11½ out |
| Saturday, September 26 |
| » Defeated Padres (36-66), 6-5 | San Diego/Jack Murphy Stadium (3-2) | 52-51 | Won 2 |
| » W: Gary Lavelle (2-6) L: Mike Armstrong (0-2) S: Greg Minton (19) | Fourth | 11½ out |
| Sunday, September 27 |
| » Defeated Padres (36-67), 7-3 | San Diego/Jack Murphy Stadium (4-2) | 53-51 | Won 3 |
| » W: Doyle Alexander (10-7) L: Chris Welsh (6-7) | Fourth | 11½ out |
| Monday, September 28 |
| » Defeated Reds (63-39), 4-0 | Riverfront Stadium (3-5) | 54-51 | Won 4 |
| » W: Alan Hargesheimer (1-1) L: Frank Pastore (4-8) | Fourth | 10½ out |
| Tuesday, September 29 |
| » Lost to Reds (64-39), 4-3 | Riverfront Stadium (3-6) | 54-52 | |
| » W: Tom Hume (9-3) L: Greg Minton (4-5) | Fourth | 11½ out |
| Wednesday, September 30 |
| » Lost to Braves (48-54), 9-2 | Atlanta-Fulton County Stadium (2-2) | 54-53 | Lost 2 |
| » W: Larry McWilliams (2-1) L: Ed Whitson (6-9) | Fourth | 12½ out |
| Thursday, October 1 |
| » Defeated Braves (48-55), 6-2 | Atlanta-Fulton County Stadium (3-2) | 55-53 | |
| » W: Doyle Alexander (11-7) L: Phil Niekro (7-7) S: Greg Minton (20) | Fourth | 11½ out |
| » Major-league debuts: Jose Alvarez (Braves) |
| Saturday, October 3 |
| » Lost to Padres (40-68), 4-3 | Candlestick Park (28-23) | 55-54 | |
| » W: Gary Lucas (7-7) L: Mike Rowland (0-1) S: Danny Boone (2) | Fourth | 11½ out |
| » Lost to Padres (41-68), 7-2 | Candlestick Park (28-24) | 55-55 | Lost 2 |
| » W: Tim Lollar (2-8) L: Alan Hargesheimer (1-2) | Fourth | 11½ out |
| Sunday, October 4 |
| » Defeated Padres (41-69), 4-3 | Candlestick Park (29-24) | 56-55 | |
| » W: Fred Breining (5-2) L: Eric Show (1-3) S: Greg Minton (21) | Fourth | 11½ out |
| Former Giant Freddie Lindstrom dies in Chicago, IL at the age of 76. |
| Monday, November 2 |
| Former Giant Hugh East dies in Charleston, SC at the age of 63. |
| Tuesday, November 10 |
| Future Giant Merkin Valdez is born in San Cristobal, D.R. |
| Tuesday, November 17 |
| Former Giant Red Shea dies in Stafford Springs, CT at the age of 83. |
| Friday, December 4 |
| Future Giant Jerome Williams is born in Honolulu, HI. |
| Thursday, December 10 |
| Former Giant Freddy Leach dies in Hagerman, ID at the age of 85. |
| Sunday, December 27 |
| Future Giant David Aardsma is born in Denver, CO. |
Game information provided by Retrosheet (www.retrosheet.org) |