| Thursday, April 9 |
| » Lost to Dodgers (1-0), 2-0 | Dodger Stadium (0-1) | 0-1 | |
| » W: Fernando Valenzuela (1-0) L: Joe Niekro (0-1) | Third | 1 out |
| Friday, April 10 |
| » Major-league debuts: Rufino Linares (Braves) |
| Saturday, April 11 |
| » Lost to Dodgers (2-0), 7-4 | Dodger Stadium (0-2) | 0-2 | Lost 2 |
| » W: Burt Hooton (1-0) L: Don Sutton (0-1) | Fifth | 2 out |
| Sunday, April 12 |
| » Lost to Dodgers (3-0), 3-2 | Dodger Stadium (0-3) | 0-3 | Lost 3 |
| » W: Rick Sutcliffe (1-0) L: Vern Ruhle (0-1) S: Steve Howe (1) | Fourth | 3 out |
| Monday, April 13 |
| » Lost to Braves (3-1), 2-1 | Astrodome (0-1) | 0-4 | Lost 4 |
| » W: Rick Camp (1-0) L: Joe Sambito (0-1) S: Larry Bradford (1) | Fifth | 4 out |
| Tuesday, April 14 |
| » Defeated Braves (3-2), 8-2 | Astrodome (1-1) | 1-4 | |
| » W: Joe Niekro (1-1) L: Bob Walk (0-1) | Fifth | 4 out |
| Wednesday, April 15 |
| » Defeated Braves (3-3), 2-0 | Astrodome (2-1) | 2-4 | Won 2 |
| » W: Nolan Ryan (1-0) L: Tommy Boggs (0-1) S: Frank LaCorte (1) | Fourth | 4 out |
| Friday, April 17 |
| » Lost to Pirates (2-4), 4-3 | Astrodome (2-2) | 2-5 | |
| » W: Rick Rhoden (2-0) L: Don Sutton (0-2) S: Enrique Romo (2) | Fifth | 4 out |
| Saturday, April 18 |
| » Lost to Pirates (3-4), 6-3 | Astrodome (2-3) | 2-6 | Lost 2 |
| » W: Grant Jackson (1-0) L: Dave Smith (0-1) | Sixth | 5 out |
| Sunday, April 19 |
| » Lost to Pirates (4-4), 2-0 | Astrodome (2-4) | 2-7 | Lost 3 |
| » W: Rod Scurry (1-0) L: Joe Niekro (1-2) S: Eddie Solomon (1) | Sixth | 6 out |
| Monday, April 20 |
| » Lost to Dodgers (9-1), 5-2 | Astrodome (2-5) | 2-8 | Lost 4 |
| » W: Burt Hooton (3-0) L: Joaquin Andujar (0-1) S: Dave Goltz (1) | Sixth | 7 out |
| Tuesday, April 21 |
| » Defeated Dodgers (9-2), 1-0 | Astrodome (3-5) | 3-8 | |
| » W: Bob Knepper (1-0) L: Jerry Reuss (0-1) | Fifth | 6 out |
| Wednesday, April 22 |
| » Lost to Dodgers (10-2), 1-0 | Astrodome (3-6) | 3-9 | |
| » W: Fernando Valenzuela (4-0) L: Don Sutton (0-3) | Fifth | 7 out |
| Thursday, April 23 |
| » Lost to Reds (6-6), 5-4 | Astrodome (3-7) | 3-10 | Lost 2 |
| » W: Joe Price (1-0) L: Dave Smith (0-2) S: Paul Moskau (1) | Fifth | 8 out |
| Friday, April 24 |
| » Lost to Reds (7-6), 3-0 | Astrodome (3-8) | 3-11 | Lost 3 |
| » W: Frank Pastore (1-0) L: Joe Niekro (1-3) | Sixth | 8 out |
| Saturday, April 25 |
| » Lost to Reds (8-6), 2-1 | Astrodome (3-9) | 3-12 | Lost 4 |
| » W: Bruce Berenyi (2-0) L: Nolan Ryan (1-1) S: Tom Hume (1) | Sixth | 9 out |
| Sunday, April 26 |
| » Defeated Reds (8-7), 1-0 | Astrodome (4-9) | 4-12 | |
| » W: Bob Knepper (2-0) L: Mario Soto (1-3) | Sixth | 9 out |
| Tuesday, April 28 |
| » Defeated Braves (9-8), 2-1 | Atlanta-Fulton County Stadium (1-0) | 5-12 | Won 2 |
| » W: Don Sutton (1-3) L: John Montefusco (1-2) S: Dave Smith (1) | Sixth | 8½ out |
| Wednesday, April 29 |
| » Defeated Braves (9-9), 5-4 | Atlanta-Fulton County Stadium (2-0) | 6-12 | Won 3 |
| » W: Frank LaCorte (1-0) L: Rick Camp (2-1) | Fifth | 7½ out |
| Thursday, April 30 |
| » Defeated Braves (9-10), 5-1 | Atlanta-Fulton County Stadium (3-0) | 7-12 | Won 4 |
| » W: Joe Niekro (2-3) L: Tommy Boggs (1-3) | Fifth | 7 out |
| Friday, May 1 |
| » Defeated Pirates (7-7), 5-3 | Three Rivers Stadium (1-0) | 8-12 | Won 5 |
| » W: Joe Sambito (1-1) L: Eddie Solomon (0-1) | Fifth | 6 out |
| Saturday, May 2 |
| » Lost to Pirates (8-7), 5-4 | Three Rivers Stadium (1-1) | 8-13 | |
| » W: Eddie Solomon (1-1) L: Dave Smith (0-3) | Fifth | 7 out |
| Sunday, May 3 |
| » Defeated Pirates (8-8), 3-1 | Three Rivers Stadium (2-1) | 9-13 | |
| » W: Don Sutton (2-3) L: Jim Bibby (1-1) S: Dave Smith (2) | Fifth | 7 out |
| Monday, May 4 |
| » Defeated Cubs (3-16), 5-4 | Wrigley Field (1-0) | 10-13 | Won 2 |
| » W: Joaquin Andujar (1-1) L: Mike Krukow (1-2) S: Joe Sambito (1) | Fourth | 6 out |
| Tuesday, May 5 |
| » Defeated Cubs (3-17), 4-3 | Wrigley Field (2-0) | 11-13 | Won 3 |
| » W: Dave Smith (1-3) L: Lee Smith (0-2) | Fourth | 5 out |
| Wednesday, May 6 |
| » Lost to Cubs (4-17), 2-1 | Wrigley Field (2-1) | 11-14 | |
| » W: Lee Smith (1-2) L: Frank LaCorte (1-1) | Fifth | 6 out |
| Thursday, May 7 |
| » Defeated Cubs (4-18), 6-0 | Wrigley Field (3-1) | 12-14 | |
| » W: Bob Knepper (3-0) L: Randy Martz (1-1) | Fourth | 6 out |
| Friday, May 8 |
| » Lost to Reds (13-12), 4-0 | Riverfront Stadium (0-1) | 12-15 | |
| » W: Tom Seaver (3-1) L: Don Sutton (2-4) | Fifth | 7 out |
| Saturday, May 9 |
| » Lost to Reds (14-12), 9-5 | Riverfront Stadium (0-2) | 12-16 | Lost 2 |
| » W: Bruce Berenyi (3-1) L: Joaquin Andujar (1-2) | Fifth | 7 out |
| Sunday, May 10 |
| » Defeated Reds (14-13), 7-5 | Riverfront Stadium (1-2) | 13-16 | |
| » W: Joe Niekro (3-3) L: Frank Pastore (1-1) S: Frank LaCorte (2) | Fifth | 7 out |
| Monday, May 11 |
| » Defeated Reds (14-14), 5-0 | Riverfront Stadium (2-2) | 14-16 | Won 2 |
| » W: Nolan Ryan (2-1) L: Mike LaCoss (1-4) | Fifth | 6½ out |
| Tuesday, May 12 |
| » Lost to Cardinals (16-7), 3-2 | Astrodome (4-10) | 14-17 | |
| » W: Bruce Sutter (1-1) L: Joe Sambito (1-2) S: Jim Kaat (2) | Fifth | 7½ out |
| Wednesday, May 13 |
| » Defeated Cardinals (16-8), 3-0 | Astrodome (5-10) | 15-17 | |
| » W: Don Sutton (3-4) L: Bob Shirley (4-1) | Fifth | 7½ out |
| Thursday, May 14 |
| » Lost to Cardinals (17-8), 7-6 | Astrodome (5-11) | 15-18 | |
| » W: Jim Otten (1-0) L: Joe Sambito (1-3) S: Bruce Sutter (6) | Fourth | 8½ out |
| Friday, May 15 |
| » Defeated Cubs (5-23), 5-0 | Astrodome (6-11) | 16-18 | |
| » W: Joe Niekro (4-3) L: Bill Caudill (0-3) | Fourth | 8½ out |
| Saturday, May 16 |
| » Defeated Cubs (5-24), 6-1 | Astrodome (7-11) | 17-18 | Won 2 |
| » W: Nolan Ryan (3-1) L: Randy Martz (1-2) S: Joe Sambito (2) | Fourth | 8½ out |
| Sunday, May 17 |
| » Defeated Cubs (5-25), 6-1 | Astrodome (8-11) | 18-18 | Won 3 |
| » W: Bob Knepper (4-0) L: Mike Krukow (1-4) | Fourth | 8½ out |
| Tuesday, May 19 |
| » Lost to Cardinals (20-9), 15-12 | Busch Stadium II (0-1) | 18-19 | |
| » W: Jim Kaat (2-0) L: Bobby Sprowl (0-1) | Fifth | 8 out |
| Wednesday, May 20 |
| » Defeated Cardinals (20-10), 4-3 | Busch Stadium II (1-1) | 19-19 | |
| » W: Joe Niekro (5-3) L: Bruce Sutter (1-2) S: Joe Sambito (3) | Fifth | 8 out |
| Thursday, May 21 |
| » Lost to Cardinals (21-10), 3-1 | Busch Stadium II (1-2) | 19-20 | |
| » W: John Martin (1-0) L: Nolan Ryan (3-2) | Fifth | 8½ out |
| Friday, May 22 |
| » Lost to Giants (22-20), 6-3 | Astrodome (8-12) | 19-21 | Lost 2 |
| » W: Greg Minton (2-2) L: Joaquin Andujar (1-3) | Fifth | 9½ out |
| Saturday, May 23 |
| » Defeated Giants (22-21), 5-3 | Astrodome (9-12) | 20-21 | |
| » W: Frank LaCorte (2-1) L: Ed Whitson (1-5) | Fifth | 9½ out |
| Sunday, May 24 |
| » Lost to Giants (23-21), 2-1 | Astrodome (9-13) | 20-22 | |
| » W: Vida Blue (4-3) L: Don Sutton (3-5) S: Greg Minton (9) | Fifth | 10 out |
| Monday, May 25 |
| » Defeated Padres (17-26), 6-3 | Astrodome (10-13) | 21-22 | |
| » W: Joe Niekro (6-3) L: Steve Mura (1-7) S: Joe Sambito (4) | Fourth | 10 out |
| Tuesday, May 26 |
| » Defeated Padres (17-27), 1-0 | Astrodome (11-13) | 22-22 | Won 2 |
| » W: Nolan Ryan (4-2) L: Juan Eichelberger (4-3) S: Joe Sambito (5) | Fourth | 9½ out |
| Wednesday, May 27 |
| » Defeated Padres (17-28), 1-0 | Astrodome (12-13) | 23-22 | Won 3 |
| » W: Bob Knepper (5-0) L: Chris Welsh (2-3) | Third | 8½ out |
| Friday, May 29 |
| » Lost to Giants (24-24), 3-1 | Candlestick Park (0-1) | 23-23 | |
| » W: Vida Blue (5-3) L: Don Sutton (3-6) S: Al Holland (2) | Fourth | 9 out |
| Saturday, May 30 |
| » Defeated Giants (24-25), 9-8 | Candlestick Park (1-1) | 24-23 | |
| » W: Joaquin Andujar (2-3) L: Fred Breining (1-1) S: Vern Ruhle (1) | Third | 8 out |
| Sunday, May 31 |
| » Lost to Giants (25-25), 6-1 | Candlestick Park (1-2) | 24-24 | |
| » W: Tom Griffin (4-3) L: Nolan Ryan (4-3) S: Al Holland (3) | Third | 9 out |
| Tuesday, June 2 |
| » Defeated Padres (19-30), 2-1 | San Diego/Jack Murphy Stadium (1-0) | 25-24 | |
| » W: Frank LaCorte (3-1) L: Chris Welsh (2-4) S: Joe Sambito (6) | Third | 8½ out |
| Wednesday, June 3 |
| » Defeated Padres (19-31), 6-1 | San Diego/Jack Murphy Stadium (2-0) | 26-24 | Won 2 |
| » W: Don Sutton (4-6) L: Rick Wise (2-5) | Third | 7½ out |
| Thursday, June 4 |
| » Lost to Padres (20-31), 7-5 | San Diego/Jack Murphy Stadium (2-1) | 26-25 | |
| » W: Steve Mura (3-7) L: Joe Niekro (6-4) S: Gary Lucas (8) | Third | 8 out |
| Friday, June 5 |
| » Defeated Mets (16-30), 3-0 | Astrodome (13-13) | 27-25 | |
| » W: Nolan Ryan (5-3) L: Randy Jones (1-6) | Third | 7 out |
| Saturday, June 6 |
| » Defeated Mets (16-31), 6-2 | Astrodome (14-13) | 28-25 | Won 2 |
| » W: Vern Ruhle (1-1) L: Pat Zachry (5-6) S: Dave Smith (3) | Third | 6 out |
| Sunday, June 7 |
| » Lost to Mets (17-31), 3-1 | Astrodome (14-14) | 28-26 | |
| » W: Mike Scott (3-4) L: Bob Knepper (5-1) S: Neil Allen (6) | Third | 7 out |
| Monday, June 8 |
| » Lost to Phillies (32-21), 4-3 | Veteran's Stadium (0-1) | 28-27 | Lost 2 |
| » W: Dick Ruthven (8-3) L: Don Sutton (4-7) S: Tug McGraw (6) | Third | 7½ out |
| Tuesday, June 9 |
| » Lost to Phillies (33-21), 10-3 | Veteran's Stadium (0-2) | 28-28 | Lost 3 |
| » W: Marty Bystrom (4-3) L: Joe Niekro (6-5) S: Ron Reed (5) | Third | 7½ out |
| » Major-league debuts: Billy Smith (Astros) |
| Wednesday, June 10 |
| » Lost to Phillies (34-21), 5-4 | Veteran's Stadium (0-3) | 28-29 | Lost 4 |
| » W: Steve Carlton (9-1) L: Frank LaCorte (3-2) S: Tug McGraw (7) | Third | 8½ out |
| Monday, August 10 |
| » Defeated Giants (27-33), 6-5 | Candlestick Park (2-2) | 29-29 | |
| » W: Joe Sambito (2-3) L: Fred Breining (2-2) S: Frank LaCorte (3) | Third | 8 out |
| » Major-league debuts: Bob Tufts (Giants) |
| Tuesday, August 11 |
| » Lost to Giants (28-33), 3-2 | Candlestick Park (2-3) | 29-30 | |
| » W: Tom Griffin (5-5) L: Joe Niekro (6-6) S: Greg Minton (10) | Third | 8 out |
| Wednesday, August 12 |
| » Defeated Giants (28-34), 5-4 | Candlestick Park (3-3) | 30-30 | |
| » W: Joe Sambito (3-3) L: Al Holland (3-3) S: Billy Smith (1) | Third | 8 out |
| Thursday, August 13 |
| » Lost to Padres (24-36), 9-1 | San Diego/Jack Murphy Stadium (2-2) | 30-31 | |
| » W: Chris Welsh (4-4) L: Bob Knepper (5-2) | Fourth | 8 out |
| Friday, August 14 |
| » Defeated Padres (24-37), 5-1 | San Diego/Jack Murphy Stadium (3-2) | 31-31 | |
| » W: Nolan Ryan (6-3) L: Tim Lollar (1-5) | Third | 8 out |
| Saturday, August 15 |
| » Defeated Padres (24-38), 5-0 | San Diego/Jack Murphy Stadium (4-2) | 32-31 | Won 2 |
| » W: Don Sutton (5-7) L: Juan Eichelberger (6-4) | Third | 7 out |
| Sunday, August 16 |
| » Defeated Padres (24-39), 3-0 | San Diego/Jack Murphy Stadium (5-2) | 33-31 | Won 3 |
| » W: Joe Niekro (7-6) L: Steve Mura (4-9) S: Dave Smith (4) | Third | 7 out |
| Monday, August 17 |
| » Lost to Expos (34-27), 6-2 | Astrodome (14-15) | 33-32 | |
| » W: Ray Burris (5-5) L: Vern Ruhle (1-2) S: Woodie Fryman (4) | Third | 7 out |
| Tuesday, August 18 |
| » Defeated Expos (34-28), 4-2 | Astrodome (15-15) | 34-32 | |
| » W: Bob Knepper (6-2) L: Steve Rogers (8-5) S: Joe Sambito (7) | Third | 7 out |
| Wednesday, August 19 |
| » Defeated Expos (34-29), 9-1 | Astrodome (16-15) | 35-32 | Won 2 |
| » W: Nolan Ryan (7-3) L: Scott Sanderson (6-4) S: Dave Smith (5) | Third | 6 out |
| » Major-league debuts: Terry Francona (Expos) |
| Thursday, August 20 |
| » Major-league debuts: Brett Butler (Braves) |
| Friday, August 21 |
| » Lost to Phillies (37-28), 5-4 | Veteran's Stadium (0-4) | 35-33 | |
| » W: Sparky Lyle (6-2) L: Vern Ruhle (1-3) S: Tug McGraw (8) | Third | 7 out |
| Saturday, August 22 |
| » Lost to Phillies (38-28), 8-4 | Veteran's Stadium (0-5) | 35-34 | Lost 2 |
| » W: Dick Ruthven (9-5) L: Joe Niekro (7-7) | Third | 8 out |
| Sunday, August 23 |
| » Lost to Phillies (39-28), 6-0 | Veteran's Stadium (0-6) | 35-35 | Lost 3 |
| » W: Steve Carlton (10-3) L: Bob Knepper (6-3) | Fourth | 8 out |
| Tuesday, August 25 |
| » Lost to Mets (26-40), 2-1 | Shea Stadium (0-1) | 35-36 | Lost 4 |
| » W: Mike Marshall (1-0) L: Joe Sambito (3-4) | Fourth | 9½ out |
| Wednesday, August 26 |
| » Defeated Mets (26-41), 9-3 | Shea Stadium (1-1) | 36-36 | |
| » W: Don Sutton (6-7) L: Pat Zachry (6-9) | Fourth | 9½ out |
| Thursday, August 27 |
| » Lost to Mets (27-41), 3-2 | Shea Stadium (1-2) | 36-37 | |
| » W: Mike Marshall (2-0) L: Joe Sambito (3-5) S: Neil Allen (12) | Fourth | 10½ out |
| Friday, August 28 |
| » Defeated Phillies (40-31), 3-2 | Astrodome (17-15) | 37-37 | |
| » W: Dave Smith (2-3) L: Sparky Lyle (6-3) | Fourth | 10½ out |
| Saturday, August 29 |
| » Defeated Phillies (40-32), 6-1 | Astrodome (18-15) | 38-37 | Won 2 |
| » W: Vern Ruhle (2-3) L: Mark Davis (0-2) | Third | 9 out |
| » Defeated Phillies (40-33), 2-1 | Astrodome (19-15) | 39-37 | Won 3 |
| » W: Billy Smith (1-0) L: Dickie Noles (0-1) S: Frank LaCorte (4) | Third | 9 out |
| Sunday, August 30 |
| » Defeated Phillies (40-34), 5-4 | Astrodome (20-15) | 40-37 | Won 4 |
| » W: Dave Smith (3-3) L: Sparky Lyle (6-4) | Third | 8 out |
| Monday, August 31 |
| » Defeated Mets (28-44), 6-1 | Astrodome (21-15) | 41-37 | Won 5 |
| » W: Don Sutton (7-7) L: Pat Zachry (6-10) | Third | 7 out |
| Tuesday, September 1 |
| » Defeated Mets (28-45), 3-2 | Astrodome (22-15) | 42-37 | Won 6 |
| » W: Joe Sambito (4-5) L: Mike Marshall (2-1) | Third | 7 out |
| » Major-league debuts: Ron Gardenhire (Mets) |
| Wednesday, September 2 |
| » Defeated Mets (28-46), 8-0 | Astrodome (23-15) | 43-37 | Won 7 |
| » W: Bob Knepper (7-3) L: Mike Scott (4-8) | Third | 7 out |
| Thursday, September 3 |
| » Defeated Expos (42-35), 2-1 | Stade Olympique (1-0) | 44-37 | Won 8 |
| » W: Vern Ruhle (3-3) L: Scott Sanderson (7-5) S: Dave Smith (6) | Third | 6 out |
| Friday, September 4 |
| » Defeated Expos (42-36), 5-0 | Stade Olympique (2-0) | 45-37 | Won 9 |
| » W: Nolan Ryan (8-3) L: Bill Gullickson (4-7) S: Joe Sambito (8) | Third | 5 out |
| Saturday, September 5 |
| » Lost to Expos (43-36), 5-2 | Stade Olympique (2-1) | 45-38 | |
| » W: Ray Burris (7-5) L: Don Sutton (7-8) | Third | 6 out |
| Sunday, September 6 |
| » Defeated Expos (43-37), 4-3 | Stade Olympique (3-1) | 46-38 | |
| » W: Frank LaCorte (4-2) L: Elias Sosa (1-2) | Third | 6 out |
| Monday, September 7 |
| » Defeated Braves (39-42), 3-2 | Atlanta-Fulton County Stadium (4-0) | 47-38 | Won 2 |
| » W: Dave Smith (4-3) L: Rick Camp (7-2) S: Joe Sambito (9) | Third | 6 out |
| Tuesday, September 8 |
| » Lost to Braves (40-42), 3-2 | Atlanta-Fulton County Stadium (4-1) | 47-39 | |
| » W: Rick Camp (8-2) L: Billy Smith (1-1) | Third | 7 out |
| Wednesday, September 9 |
| » Lost to Braves (41-42), 9-0 | Atlanta-Fulton County Stadium (4-2) | 47-40 | Lost 2 |
| » W: Phil Niekro (7-5) L: Nolan Ryan (8-4) | Third | 7 out |
| Friday, September 11 |
| » Defeated Giants (44-45), 6-0 | Astrodome (24-15) | 48-40 | |
| » W: Don Sutton (8-8) L: Vida Blue (8-6) | Third | 6 out |
| Saturday, September 12 |
| » Defeated Giants (44-46), 5-2 | Astrodome (25-15) | 49-40 | Won 2 |
| » W: Joe Niekro (8-7) L: Ed Whitson (5-8) S: Dave Smith (7) | Third | 5 out |
| Sunday, September 13 |
| » Defeated Giants (44-47), 3-0 | Astrodome (26-15) | 50-40 | Won 3 |
| » W: Bob Knepper (8-3) L: Doyle Alexander (8-7) S: Frank LaCorte (5) | Third | 5 out |
| Monday, September 14 |
| » Lost to Reds (53-36), 4-2 | Astrodome (26-16) | 50-41 | |
| » W: Bruce Berenyi (8-5) L: Vern Ruhle (3-4) | Third | 6 out |
| Tuesday, September 15 |
| » Lost to Reds (54-36), 4-0 | Astrodome (26-17) | 50-42 | Lost 2 |
| » W: Charlie Leibrandt (1-0) L: Nolan Ryan (8-5) | Third | 6 out |
| Wednesday, September 16 |
| » Defeated Padres (34-59), 5-2 | San Diego/Jack Murphy Stadium (6-2) | 51-42 | |
| » W: Don Sutton (9-8) L: Tim Lollar (1-8) S: Joe Sambito (10) | Third | 6 out |
| Thursday, September 17 |
| » Defeated Padres (34-60), 9-0 | San Diego/Jack Murphy Stadium (7-2) | 52-42 | Won 2 |
| » W: Joe Niekro (9-7) L: Steve Mura (5-13) | Third | 6 out |
| Friday, September 18 |
| » Lost to Giants (48-48), 5-2 | Candlestick Park (3-4) | 52-43 | |
| » W: Doyle Alexander (9-7) L: Bob Knepper (8-4) S: Al Holland (7) | Third | 6 out |
| Saturday, September 19 |
| » Defeated Giants (48-49), 8-1 | Candlestick Park (4-4) | 53-43 | |
| » W: Vern Ruhle (4-4) L: Tom Griffin (8-7) | Third | 5 out |
| Sunday, September 20 |
| » Defeated Giants (48-50), 7-3 | Candlestick Park (5-4) | 54-43 | Won 2 |
| » W: Nolan Ryan (9-5) L: Gary Lavelle (0-6) | Third | 5 out |
| Tuesday, September 22 |
| » Defeated Braves (45-49), 3-0 | Astrodome (27-17) | 55-43 | Won 3 |
| » W: Don Sutton (10-8) L: Gaylord Perry (7-8) | Third | 4½ out |
| » Major-league debuts: Matt Sinatro (Braves) |
| Wednesday, September 23 |
| » Lost to Braves (46-49), 3-1 | Astrodome (27-18) | 55-44 | |
| » W: Rick Mahler (6-6) L: Joe Niekro (9-8) | Third | 5½ out |
| Thursday, September 24 |
| » Defeated Braves (46-50), 5-3 | Astrodome (28-18) | 56-44 | |
| » W: Bob Knepper (9-4) L: Larry McWilliams (1-1) S: Dave Smith (8) | Third | 5 out |
| Friday, September 25 |
| » Lost to Dodgers (60-41), 3-0 | Astrodome (28-19) | 56-45 | |
| » W: Burt Hooton (11-6) L: Vern Ruhle (4-5) | Third | 6 out |
| Saturday, September 26 |
| » Defeated Dodgers (60-42), 5-0 | Astrodome (29-19) | 57-45 | |
| » W: Nolan Ryan (10-5) L: Ted Power (1-3) | Third | 6 out |
| Sunday, September 27 |
| » Defeated Dodgers (60-43), 4-1 | Astrodome (30-19) | 58-45 | Won 2 |
| » W: Don Sutton (11-8) L: Fernando Valenzuela (13-6) | Third | 6 out |
| Monday, September 28 |
| » Defeated Padres (36-68), 2-1 | Astrodome (31-19) | 59-45 | Won 3 |
| » W: Joe Sambito (5-5) L: Juan Eichelberger (8-8) | Third | 5 out |
| Tuesday, September 29 |
| » Lost to Padres (37-68), 2-1 | Astrodome (31-20) | 59-46 | |
| » W: Rick Wise (4-8) L: Bob Knepper (9-5) S: Gary Lucas (12) | Third | 6 out |
| Wednesday, September 30 |
| » Lost to Reds (65-39), 5-2 | Riverfront Stadium (2-3) | 59-47 | Lost 2 |
| » W: Mario Soto (11-9) L: Vern Ruhle (4-6) S: Tom Hume (13) | Third | 7 out |
| Thursday, October 1 |
| » Defeated Reds (65-40), 8-1 | Riverfront Stadium (3-3) | 60-47 | |
| » W: Nolan Ryan (11-5) L: Bruce Berenyi (9-6) | Third | 6 out |
| Friday, October 2 |
| » Lost to Dodgers (62-46), 6-1 | Dodger Stadium (0-4) | 60-48 | |
| » W: Jerry Reuss (10-4) L: Don Sutton (11-9) | Third | 6 out |
| Saturday, October 3 |
| » Lost to Dodgers (63-46), 7-2 | Dodger Stadium (0-5) | 60-49 | Lost 2 |
| » W: Bob Welch (9-5) L: Joe Niekro (9-9) | Third | 6 out |
| Sunday, October 4 |
| » Defeated Dodgers (63-47), 5-3 | Dodger Stadium (1-5) | 61-49 | |
| » W: Dave Smith (5-3) L: Dave Goltz (2-7) | Third | 6 out |
| Friday, December 25 |
| Future Astro Willy Taveras is born in Tenares, D.R. |
Game information provided by Retrosheet (www.retrosheet.org) |