| Thursday, April 10 |
| » Defeated White Sox (0-1), 5-3 | Comiskey Park I (1-0) | 1-0 | |
| » W: Jim Palmer (1-0) L: Steve Trout (0-1) S: Tim Stoddard (1) | First | -- |
| » Major-league debuts: Harold Baines (White Sox) |
| Friday, April 11 |
| » Lost to White Sox (1-1), 8-4 | Comiskey Park I (1-1) | 1-1 | |
| » W: Ken Kravec (1-0) L: Mike Flanagan (0-1) S: Ed Farmer (1) | Second | ½ out |
| Saturday, April 12 |
| » Lost to White Sox (2-1), 8-2 | Comiskey Park I (1-2) | 1-2 | Lost 2 |
| » W: Richard Dotson (1-0) L: Steve Stone (0-1) | Third | 1½ out |
| Sunday, April 13 |
| » Lost to White Sox (3-1), 5-2 | Comiskey Park I (1-3) | 1-3 | Lost 3 |
| » W: Ross Baumgarten (1-0) L: Sammy Stewart (0-1) S: Ed Farmer (2) | Fourth | 1½ out |
| Tuesday, April 15 |
| » Defeated Royals (3-2), 12-2 | Memorial Stadium (1-0) | 2-3 | |
| » W: Jim Palmer (2-0) L: Dennis Leonard (0-2) | Third | 1 out |
| Wednesday, April 16 |
| » Defeated Royals (3-3), 2-1 | Memorial Stadium (2-0) | 3-3 | Won 2 |
| » W: Mike Flanagan (1-1) L: Larry Gura (1-1) | Third | ½ out |
| Thursday, April 17 |
| » Defeated Royals (3-4), 5-2 | Memorial Stadium (3-0) | 4-3 | Won 3 |
| » W: Steve Stone (1-1) L: Rich Gale (0-1) S: Tim Stoddard (2) | Second | ½ out |
| » Major-league debuts: Floyd Rayford (Orioles) |
| Friday, April 18 |
| » Defeated White Sox (5-3), 5-2 | Memorial Stadium (4-0) | 5-3 | Won 4 |
| » W: Dave Ford (1-0) L: Richard Dotson (1-1) | First | -- |
| Saturday, April 19 |
| » Lost to White Sox (6-3), 5-4 | Memorial Stadium (4-1) | 5-4 | |
| » W: Ed Farmer (1-0) L: Tippy Martinez (0-1) | Second | 1 out |
| Sunday, April 20 |
| » Lost to White Sox (7-3), 9-6 | Memorial Stadium (4-2) | 5-5 | Lost 2 |
| » W: Rich Wortham (2-0) L: Sammy Stewart (0-2) S: Ed Farmer (4) | Third | ½ out |
| Monday, April 21 |
| » Lost to Yankees (5-6), 3-2 | Yankee Stadium (0-1) | 5-6 | Lost 3 |
| » W: Tommy John (2-0) L: Mike Flanagan (1-2) S: Rich Gossage (1) | Third | 1½ out |
| Tuesday, April 22 |
| » Lost to Yankees (6-6), 5-4 | Yankee Stadium (0-2) | 5-7 | Lost 4 |
| » W: Tom Underwood (1-1) L: Tim Stoddard (0-1) | Fifth | 2 out |
| Wednesday, April 23 |
| » Lost to Yankees (7-6), 6-5 | Yankee Stadium (0-3) | 5-8 | Lost 5 |
| » W: Ron Davis (2-1) L: Jim Palmer (2-1) S: Rich Gossage (2) | Fourth | 2 out |
| Friday, April 25 |
| » Lost to Royals (8-6), 7-0 | Royals Stadium (0-1) | 5-9 | Lost 6 |
| » W: Larry Gura (2-1) L: Steve Stone (1-2) | Fourth | 2 out |
| Saturday, April 26 |
| » Defeated Royals (8-7), 4-0 | Royals Stadium (1-1) | 6-9 | |
| » W: Mike Flanagan (2-2) L: Rich Gale (0-3) | Fifth | 2 out |
| Sunday, April 27 |
| » Lost to Royals (9-7), 3-2 | Royals Stadium (1-2) | 6-10 | |
| » W: Paul Splittorff (3-0) L: Dave Ford (1-1) | Fifth | 3 out |
| Tuesday, April 29 |
| » Lost to Yankees (9-8), 4-3 | Memorial Stadium (4-3) | 6-11 | Lost 2 |
| » W: Luis Tiant (2-1) L: Scott McGregor (0-1) S: Rudy May (1) | Fifth | 4 out |
| Wednesday, April 30 |
| » Defeated Yankees (9-9), 7-4 | Memorial Stadium (5-3) | 7-11 | |
| » W: Steve Stone (2-2) L: Tom Underwood (1-3) S: Tim Stoddard (3) | Fifth | 3 out |
| Friday, May 2 |
| » Defeated Rangers (10-9), 7-5 | Arlington Stadium (1-0) | 8-11 | Won 2 |
| » W: Mike Flanagan (3-2) L: Jim Kern (1-3) S: Tim Stoddard (4) | Fourth | 2 out |
| Saturday, May 3 |
| » Lost to Rangers (11-9), 3-2 | Arlington Stadium (1-1) | 8-12 | |
| » W: Fergie Jenkins (2-2) L: Jim Palmer (2-2) | Fourth | 3 out |
| Sunday, May 4 |
| » Defeated Rangers (11-10), 9-5 | Arlington Stadium (2-1) | 9-12 | |
| » W: Dennis Martinez (1-0) L: Steve Comer (1-3) S: Dave Ford (1) | Fourth | 3 out |
| Monday, May 5 |
| » Lost to Twins (11-13), 4-2 | Memorial Stadium (5-4) | 9-13 | |
| » W: Pete Redfern (4-1) L: Steve Stone (2-3) S: Doug Corbett (1) | Fourth | 3½ out |
| Tuesday, May 6 |
| » Defeated Twins (11-14), 10-3 | Memorial Stadium (6-4) | 10-13 | |
| » W: Scott McGregor (1-1) L: Geoff Zahn (2-3) | Fourth | 3½ out |
| Wednesday, May 7 |
| » Defeated Twins (11-15), 8-6 | Memorial Stadium (7-4) | 11-13 | Won 2 |
| » W: Sammy Stewart (1-2) L: Mike Marshall (0-3) S: Tippy Martinez (1) | Fourth | 3½ out |
| » Major-league debuts: Al Williams (Twins) |
| Thursday, May 8 |
| » Lost to Brewers (11-11), 9-1 | County Stadium (0-1) | 11-14 | |
| » W: Moose Haas (3-3) L: Dennis Martinez (1-1) | Fifth | 4½ out |
| Friday, May 9 |
| » Defeated Brewers (11-12), 5-2 | County Stadium (1-1) | 12-14 | |
| » W: Steve Stone (3-3) L: Jerry Augustine (0-2) S: Tim Stoddard (5) | Fourth | 4 out |
| Saturday, May 10 |
| » Lost to Brewers (12-12), 5-3 | County Stadium (1-2) | 12-15 | |
| » W: Lary Sorensen (2-2) L: Scott McGregor (1-2) S: Reggie Cleveland (2) | Fourth | 4 out |
| Sunday, May 11 |
| » Lost to Brewers (13-12), 5-4 | County Stadium (1-3) | 12-16 | Lost 2 |
| » W: Reggie Cleveland (2-1) L: Sammy Stewart (1-3) S: Bob McClure (2) | Fifth | 5 out |
| Monday, May 12 |
| » Lost to Rangers (16-12), 5-1 | Memorial Stadium (7-5) | 12-17 | Lost 3 |
| » W: Jon Matlack (3-0) L: Dave Ford (1-2) | Seventh | 5 out |
| Tuesday, May 13 |
| » Defeated Rangers (16-13), 4-2 | Memorial Stadium (8-5) | 13-17 | |
| » W: Steve Stone (4-3) L: Fergie Jenkins (2-3) S: Tim Stoddard (6) | Sixth | 4 out |
| Wednesday, May 14 |
| » Lost to Rangers (17-13), 6-3 | Memorial Stadium (8-6) | 13-18 | |
| » W: Gaylord Perry (3-1) L: Paul Hartzell (0-1) S: Sparky Lyle (3) | Sixth | 5 out |
| Friday, May 16 |
| » Defeated Tigers (14-17), 2-1 | Tiger Stadium (1-0) | 14-18 | |
| » W: Mike Flanagan (4-2) L: Dan Petry (2-1) | Sixth | 5 out |
| Sunday, May 18 |
| » Lost to Tigers (15-17), 6-4 | Tiger Stadium (1-1) | 14-19 | |
| » W: Aurelio Lopez (3-2) L: Tim Stoddard (0-2) | Sixth | 5½ out |
| Monday, May 19 |
| » Defeated Indians (13-19), 4-1 | Cleveland Stadium (1-0) | 15-19 | |
| » W: Steve Stone (5-3) L: Rick Waits (2-5) S: Tim Stoddard (7) | Sixth | 5½ out |
| Tuesday, May 20 |
| » Lost to Indians (14-19), 4-0 | Cleveland Stadium (1-1) | 15-20 | |
| » W: John Denny (3-4) L: Sammy Stewart (1-4) | Sixth | 5 out |
| » Defeated Indians (14-20), 8-0 | Cleveland Stadium (2-1) | 16-20 | |
| » W: Jim Palmer (3-2) L: Bob Owchinko (0-4) | Sixth | 5 out |
| Wednesday, May 21 |
| » Lost to Indians (15-20), 4-2 | Cleveland Stadium (2-2) | 16-21 | |
| » W: Len Barker (5-2) L: Mike Flanagan (4-3) S: Sid Monge (4) | Sixth | 6 out |
| Thursday, May 22 |
| » Defeated Tigers (16-20), 5-1 | Memorial Stadium (9-6) | 17-21 | |
| » W: Scott McGregor (2-2) L: Dan Petry (2-2) | Fifth | 6 out |
| Friday, May 23 |
| » Defeated Tigers (16-21), 5-3 | Memorial Stadium (10-6) | 18-21 | Won 2 |
| » W: Steve Stone (6-3) L: Jack Morris (4-5) S: Tippy Martinez (2) | Fifth | 6 out |
| Saturday, May 24 |
| » Defeated Tigers (16-22), 9-1 | Memorial Stadium (11-6) | 19-21 | Won 3 |
| » W: Jim Palmer (4-2) L: Milt Wilcox (2-4) | Fifth | 6 out |
| Sunday, May 25 |
| » Lost to Tigers (17-22), 6-4 | Memorial Stadium (11-7) | 19-22 | |
| » W: Aurelio Lopez (4-3) L: Tippy Martinez (0-2) | Fifth | 6 out |
| Monday, May 26 |
| » Defeated Indians (17-22), 7-3 | Memorial Stadium (12-7) | 20-22 | |
| » W: Scott McGregor (3-2) L: Len Barker (5-3) S: Tim Stoddard (8) | Fifth | 6 out |
| Tuesday, May 27 |
| » Lost to Indians (18-22), 7-6 | Memorial Stadium (12-8) | 20-23 | |
| » W: Victor Cruz (2-2) L: Dave Ford (1-3) | Fifth | 7 out |
| Wednesday, May 28 |
| » Lost to Indians (19-22), 10-6 | Memorial Stadium (12-9) | 20-24 | Lost 2 |
| » W: Rick Waits (4-5) L: Jim Palmer (4-3) S: Sid Monge (5) | Sixth | 7 out |
| Friday, May 30 |
| » Defeated Twins (18-28), 3-2 | Metropolitan Stadium (1-0) | 21-24 | |
| » W: Mike Flanagan (5-3) L: Doug Corbett (3-2) S: Tippy Martinez (3) | Fourth | 7 out |
| Saturday, May 31 |
| » Defeated Twins (18-29), 11-1 | Metropolitan Stadium (2-0) | 22-24 | Won 2 |
| » W: Scott McGregor (4-2) L: Geoff Zahn (3-7) | Fifth | 7 out |
| Monday, June 2 |
| » Defeated Brewers (24-21), 9-8 | Memorial Stadium (13-9) | 23-24 | Won 3 |
| » W: Tippy Martinez (1-2) L: Bob McClure (1-2) | Fourth | 7½ out |
| Tuesday, June 3 |
| » Lost to Brewers (25-21), 3-0 | Memorial Stadium (13-10) | 23-25 | |
| » W: Moose Haas (6-4) L: Sammy Stewart (1-5) | Fifth | 7½ out |
| Wednesday, June 4 |
| » Lost to Brewers (26-21), 3-2 | Memorial Stadium (13-11) | 23-26 | Lost 2 |
| » W: Lary Sorensen (5-4) L: Mike Flanagan (5-4) S: Bob McClure (5) | Sixth | 7½ out |
| Friday, June 6 |
| » Defeated Angels (20-28), 6-1 | Anaheim Stadium (1-0) | 24-26 | |
| » W: Scott McGregor (5-2) L: Bruce Kison (3-5) | Fifth | 7½ out |
| Saturday, June 7 |
| » Defeated Angels (20-29), 6-5 | Anaheim Stadium (2-0) | 25-26 | Won 2 |
| » W: Jim Palmer (5-3) L: Dave Frost (4-4) S: Tim Stoddard (9) | Fourth | 7½ out |
| Sunday, June 8 |
| » Defeated Angels (20-30), 13-8 | Anaheim Stadium (3-0) | 26-26 | Won 3 |
| » W: Sammy Stewart (2-5) L: Chris Knapp (1-3) | Fourth | 6½ out |
| Monday, June 9 |
| » Defeated Athletics (26-28), 3-2 | Oakland-Alameda County Stadium (1-0) | 27-26 | Won 4 |
| » W: Mike Flanagan (6-4) L: Rick Langford (4-5) | Third | 6½ out |
| Tuesday, June 10 |
| » Lost to Athletics (27-28), 7-4 | Oakland-Alameda County Stadium (1-1) | 27-27 | |
| » W: Steve McCatty (6-5) L: Scott McGregor (5-3) | Fourth | 6½ out |
| Wednesday, June 11 |
| » Lost to Athletics (28-28), 6-2 | Oakland-Alameda County Stadium (1-2) | 27-28 | Lost 2 |
| » W: Mike Norris (7-4) L: Sammy Stewart (2-6) | Fifth | 7½ out |
| Thursday, June 12 |
| » Defeated Mariners (26-31), 4-1 | Kingdome (1-0) | 28-28 | |
| » W: Steve Stone (7-3) L: Rick Honeycutt (7-3) | Fourth | 7 out |
| Friday, June 13 |
| » Lost to Mariners (27-31), 7-6 | Kingdome (1-1) | 28-29 | |
| » W: Glenn Abbott (6-2) L: Mike Flanagan (6-5) S: Dave Heaverlo (4) | Fifth | 7½ out |
| Saturday, June 14 |
| » Lost to Mariners (28-31), 9-8 | Kingdome (1-2) | 28-30 | Lost 2 |
| » W: Dave Roberts (1-1) L: Paul Hartzell (0-2) S: Shane Rawley (4) | Sixth | 8½ out |
| Sunday, June 15 |
| » Defeated Mariners (28-32), 9-3 | Kingdome (2-2) | 29-30 | |
| » W: Sammy Stewart (3-6) L: Floyd Bannister (3-6) | Sixth | 8½ out |
| Monday, June 16 |
| » Defeated Angels (21-37), 5-2 | Memorial Stadium (14-11) | 30-30 | Won 2 |
| » W: Jim Palmer (6-3) L: Chris Knapp (1-4) S: Tim Stoddard (10) | Fifth | 8½ out |
| Tuesday, June 17 |
| » Defeated Angels (21-38), 5-3 | Memorial Stadium (15-11) | 31-30 | Won 3 |
| » W: Steve Stone (8-3) L: Dave Frost (4-6) | Fifth | 8½ out |
| Wednesday, June 18 |
| » Defeated Athletics (30-33), 3-2 | Memorial Stadium (16-11) | 32-30 | Won 4 |
| » W: Mike Flanagan (7-5) L: Jeff Jones (1-2) | Fourth | 8½ out |
| Thursday, June 19 |
| » Defeated Athletics (30-34), 4-3 | Memorial Stadium (17-11) | 33-30 | Won 5 |
| » W: Scott McGregor (6-3) L: Rick Langford (4-7) | Fourth | 8½ out |
| Friday, June 20 |
| » Lost to Mariners (29-36), 3-1 | Memorial Stadium (17-12) | 33-31 | |
| » W: Floyd Bannister (4-6) L: Jim Palmer (6-4) | Fifth | 9½ out |
| Saturday, June 21 |
| » Defeated Mariners (29-37), 9-0 | Memorial Stadium (18-12) | 34-31 | |
| » W: Steve Stone (9-3) L: Dave Roberts (1-2) | Fourth | 9½ out |
| Sunday, June 22 |
| » Lost to Mariners (30-37), 7-5 | Memorial Stadium (18-13) | 34-32 | |
| » W: Shane Rawley (3-1) L: Tim Stoddard (0-3) | Sixth | 9½ out |
| Tuesday, June 24 |
| » Defeated Blue Jays (31-33), 1-0 | Memorial Stadium (19-13) | 35-32 | |
| » W: Scott McGregor (7-3) L: Dave Stieb (6-5) | Fifth | 9 out |
| Wednesday, June 25 |
| » Defeated Blue Jays (31-34), 6-3 | Memorial Stadium (20-13) | 36-32 | Won 2 |
| » W: Jim Palmer (7-4) L: Luis Leal (1-2) | Fifth | 8 out |
| Thursday, June 26 |
| » Defeated Blue Jays (31-35), 4-1 | Memorial Stadium (21-13) | 37-32 | Won 3 |
| » W: Steve Stone (10-3) L: Jim Clancy (6-4) | Fifth | 7½ out |
| Friday, June 27 |
| » Lost to Red Sox (38-31), 3-2 | Fenway Park (0-1) | 37-33 | |
| » W: Chuck Rainey (8-3) L: Mike Flanagan (7-6) S: Tom Burgmeier (13) | Fifth | 7½ out |
| Saturday, June 28 |
| » Defeated Red Sox (38-32), 8-4 | Fenway Park (1-1) | 38-33 | |
| » W: Scott McGregor (8-3) L: Mike Torrez (4-7) | Fifth | 7½ out |
| Monday, June 30 |
| » Defeated Blue Jays (32-38), 9-7 | Exhibition Stadium (1-0) | 39-33 | Won 2 |
| » W: Steve Stone (11-3) L: Luis Leal (1-3) | Fourth | 8 out |
| Tuesday, July 1 |
| » Defeated Blue Jays (32-39), 2-0 | Exhibition Stadium (2-0) | 40-33 | Won 3 |
| » W: Jim Palmer (8-4) L: Jim Clancy (6-5) S: Tippy Martinez (4) | Third | 8 out |
| Wednesday, July 2 |
| » Defeated Blue Jays (32-40), 6-2 | Exhibition Stadium (3-0) | 41-33 | Won 4 |
| » W: Mike Flanagan (8-6) L: Paul Mirabella (4-8) | Third | 8 out |
| Thursday, July 3 |
| » Lost to Red Sox (39-35), 5-2 | Memorial Stadium (21-14) | 41-34 | |
| » W: Win Remmerswaal (1-0) L: Scott McGregor (8-4) S: Tom Burgmeier (14) | Fourth | 8 out |
| Friday, July 4 |
| » Defeated Red Sox (39-36), 10-3 | Memorial Stadium (22-14) | 42-34 | |
| » W: Steve Stone (12-3) L: Mike Torrez (4-8) S: Tim Stoddard (11) | Fourth | 8 out |
| Saturday, July 5 |
| » Lost to Red Sox (40-36), 1-0 | Memorial Stadium (22-15) | 42-35 | |
| » W: John Tudor (1-1) L: Jim Palmer (8-5) S: Tom Burgmeier (15) | Fourth | 9 out |
| Sunday, July 6 |
| » Lost to Red Sox (41-36), 6-4 | Memorial Stadium (22-16) | 42-36 | Lost 2 |
| » W: Dennis Eckersley (5-6) L: Mike Flanagan (8-7) S: Bob Stanley (1) | Fourth | 9 out |
| Thursday, July 10 |
| » Defeated White Sox (38-42), 9-2 | Comiskey Park I (2-3) | 43-36 | |
| » W: Scott McGregor (9-4) L: Britt Burns (9-7) | Fourth | 9 out |
| Friday, July 11 |
| » Lost to White Sox (39-42), 5-4 | Comiskey Park I (2-4) | 43-37 | |
| » W: Mike Proly (1-3) L: Jim Palmer (8-6) S: Ed Farmer (18) | Fourth | 9 out |
| Saturday, July 12 |
| » Defeated Royals (49-34), 3-1 | Memorial Stadium (23-16) | 44-37 | |
| » W: Steve Stone (13-3) L: Renie Martin (8-6) S: Tim Stoddard (12) | Third | 9 out |
| Sunday, July 13 |
| » Lost to Royals (50-34), 5-1 | Memorial Stadium (23-17) | 44-38 | |
| » W: Larry Gura (11-4) L: Mike Flanagan (8-8) | Third | 10 out |
| Monday, July 14 |
| » Lost to Royals (51-34), 8-4 | Memorial Stadium (23-18) | 44-39 | Lost 2 |
| » W: Paul Splittorff (7-6) L: Scott McGregor (9-5) S: Dan Quisenberry (17) | Fourth | 11 out |
| Tuesday, July 15 |
| » Defeated Brewers (48-37), 7-3 | County Stadium (2-3) | 45-39 | |
| » W: Jim Palmer (9-6) L: Reggie Cleveland (7-4) | Fourth | 10 out |
| Wednesday, July 16 |
| » Defeated Brewers (48-38), 10-4 | County Stadium (3-3) | 46-39 | Won 2 |
| » W: Steve Stone (14-3) L: Mike Caldwell (8-6) S: Sammy Stewart (1) | Fourth | 10 out |
| Thursday, July 17 |
| » Defeated Brewers (48-39), 1-0 | County Stadium (4-3) | 47-39 | Won 3 |
| » W: Dennis Martinez (2-1) L: Bill Travers (9-4) S: Tippy Martinez (5) | Third | 10 out |
| Friday, July 18 |
| » Defeated Rangers (42-46), 8-7 | Memorial Stadium (24-18) | 48-39 | Won 4 |
| » W: Mike Flanagan (9-8) L: Jim Kern (2-11) S: Tippy Martinez (6) | Third | 9 out |
| Saturday, July 19 |
| » Lost to Rangers (43-46), 11-8 | Memorial Stadium (24-19) | 48-40 | |
| » W: Danny Darwin (8-1) L: Sammy Stewart (3-7) | Fourth | 10 out |
| Sunday, July 20 |
| » Lost to Rangers (44-46), 7-1 | Memorial Stadium (24-20) | 48-41 | Lost 2 |
| » W: Fergie Jenkins (8-8) L: Jim Palmer (9-7) | Fourth | 10 out |
| Monday, July 21 |
| » Lost to Twins (43-48), 8-7 | Metropolitan Stadium (2-1) | 48-42 | Lost 3 |
| » W: John Verhoeven (1-2) L: Tippy Martinez (1-3) | Fourth | 9½ out |
| » Defeated Twins (43-49), 12-5 | Metropolitan Stadium (3-1) | 49-42 | |
| » W: Steve Stone (15-3) L: Geoff Zahn (8-12) | Fourth | 9½ out |
| Tuesday, July 22 |
| » Defeated Twins (43-50), 8-4 | Metropolitan Stadium (4-1) | 50-42 | Won 2 |
| » W: Mike Flanagan (10-8) L: Roger Erickson (3-7) | Fourth | 9 out |
| Wednesday, July 23 |
| » Defeated Twins (43-51), 8-7 | Metropolitan Stadium (5-1) | 51-42 | Won 3 |
| » W: Scott McGregor (10-5) L: Fernando Arroyo (2-3) S: Tippy Martinez (7) | Fourth | 9 out |
| Friday, July 25 |
| » Lost to Brewers (53-42), 5-0 | Memorial Stadium (24-21) | 51-43 | |
| » W: Reggie Cleveland (8-4) L: Jim Palmer (9-8) | Fourth | 9 out |
| Saturday, July 26 |
| » Defeated Brewers (53-43), 4-1 | Memorial Stadium (25-21) | 52-43 | |
| » W: Steve Stone (16-3) L: Mike Caldwell (9-7) S: Tim Stoddard (13) | Fourth | 9 out |
| Sunday, July 27 |
| » Defeated Brewers (53-44), 5-4 | Memorial Stadium (26-21) | 53-43 | Won 2 |
| » W: Tim Stoddard (1-3) L: Bob McClure (1-5) | Third | 8 out |
| Tuesday, July 29 |
| » Defeated Rangers (48-50), 4-3 | Arlington Stadium (3-1) | 54-43 | Won 3 |
| » W: Scott McGregor (11-5) L: Charlie Hough (2-4) S: Tippy Martinez (8) | Second | 7½ out |
| Wednesday, July 30 |
| » Defeated Rangers (48-51), 3-2 | Arlington Stadium (4-1) | 55-43 | Won 4 |
| » W: Jim Palmer (10-8) L: Gaylord Perry (5-8) S: Tim Stoddard (14) | Second | 6½ out |
| Thursday, July 31 |
| » Lost to Rangers (49-51), 7-4 | Arlington Stadium (4-2) | 55-44 | |
| » W: Fergie Jenkins (9-9) L: Steve Stone (16-4) S: Danny Darwin (2) | Second | 7½ out |
| Friday, August 1 |
| » Defeated Twins (47-55), 3-2 | Memorial Stadium (27-21) | 56-44 | |
| » W: Mike Flanagan (11-8) L: Doug Corbett (7-3) | Second | 7½ out |
| Saturday, August 2 |
| » Defeated Twins (47-56), 9-2 | Memorial Stadium (28-21) | 57-44 | Won 2 |
| » W: Scott McGregor (12-5) L: Fernando Arroyo (2-4) | Second | 7½ out |
| Sunday, August 3 |
| » Defeated Twins (47-57), 7-2 | Memorial Stadium (29-21) | 58-44 | Won 3 |
| » W: Jim Palmer (11-8) L: Darrell Jackson (7-6) S: Tim Stoddard (15) | Second | 6½ out |
| Tuesday, August 5 |
| » Defeated White Sox (46-58), 8-2 | Memorial Stadium (30-21) | 59-44 | Won 4 |
| » W: Steve Stone (17-4) L: La Marr Hoyt (4-1) | Second | 6 out |
| Wednesday, August 6 |
| » Defeated White Sox (46-59), 4-1 | Memorial Stadium (31-21) | 60-44 | Won 5 |
| » W: Mike Flanagan (12-8) L: Britt Burns (10-10) S: Tim Stoddard (16) | Second | 6 out |
| Thursday, August 7 |
| » Defeated White Sox (46-60), 2-1 | Memorial Stadium (32-21) | 61-44 | Won 6 |
| » W: Scott McGregor (13-5) L: Steve Trout (6-12) | Second | 5½ out |
| Friday, August 8 |
| » Defeated Yankees (67-40), 5-2 | Yankee Stadium (1-3) | 62-44 | Won 7 |
| » W: Jim Palmer (12-8) L: Ron Guidry (12-7) S: Tim Stoddard (17) | Second | 4½ out |
| Saturday, August 9 |
| » Defeated Yankees (67-41), 4-2 | Yankee Stadium (2-3) | 63-44 | Won 8 |
| » W: Steve Stone (18-4) L: Tom Underwood (9-8) | Second | 3½ out |
| Sunday, August 10 |
| » Defeated Yankees (67-42), 6-5 | Yankee Stadium (3-3) | 64-44 | Won 9 |
| » W: Tim Stoddard (2-3) L: Tommy John (15-6) | Second | 2½ out |
| Monday, August 11 |
| » Defeated Royals (70-42), 2-1 | Royals Stadium (2-2) | 65-44 | Won 10 |
| » W: Dennis Martinez (3-1) L: Larry Gura (16-5) | Second | 2½ out |
| Tuesday, August 12 |
| » Lost to Royals (71-42), 4-3 | Royals Stadium (2-3) | 65-45 | |
| » W: Dan Quisenberry (9-4) L: Scott McGregor (13-6) | Second | 3½ out |
| Wednesday, August 13 |
| » Lost to Royals (72-42), 6-1 | Royals Stadium (2-4) | 65-46 | Lost 2 |
| » W: Rich Gale (11-7) L: Jim Palmer (12-9) | Second | 3½ out |
| Thursday, August 14 |
| » Defeated Yankees (69-44), 6-1 | Memorial Stadium (33-21) | 66-46 | |
| » W: Steve Stone (19-4) L: Tom Underwood (9-9) | Second | 2½ out |
| Friday, August 15 |
| » Lost to Yankees (70-44), 4-3 | Memorial Stadium (33-22) | 66-47 | |
| » W: Tommy John (16-6) L: Mike Flanagan (12-9) S: Rich Gossage (17) | Second | 3½ out |
| Saturday, August 16 |
| » Lost to Yankees (71-44), 4-1 | Memorial Stadium (33-23) | 66-48 | Lost 2 |
| » W: Gaylord Perry (7-9) L: Dennis Martinez (3-2) S: Rich Gossage (18) | Second | 4½ out |
| Sunday, August 17 |
| » Defeated Yankees (71-45), 1-0 | Memorial Stadium (34-23) | 67-48 | |
| » W: Scott McGregor (14-6) L: Luis Tiant (6-7) | Second | 3½ out |
| Monday, August 18 |
| » Defeated Yankees (71-46), 6-5 | Memorial Stadium (35-23) | 68-48 | Won 2 |
| » W: Jim Palmer (13-9) L: Ron Guidry (12-9) S: Tim Stoddard (18) | Second | 2½ out |
| Tuesday, August 19 |
| » Defeated Angels (48-69), 5-2 | Anaheim Stadium (4-0) | 69-48 | Won 3 |
| » W: Steve Stone (20-4) L: Alfredo Martinez (3-5) S: Tippy Martinez (9) | Second | 2½ out |
| Wednesday, August 20 |
| » Defeated Angels (48-70), 6-5 | Anaheim Stadium (5-0) | 70-48 | Won 4 |
| » W: Tim Stoddard (3-3) L: Mark Clear (9-10) | Second | 2½ out |
| Thursday, August 21 |
| » Defeated Angels (48-71), 7-1 | Anaheim Stadium (6-0) | 71-48 | Won 5 |
| » W: Scott McGregor (15-6) L: Chris Knapp (2-9) | Second | 1½ out |
| Friday, August 22 |
| » Defeated Athletics (63-60), 3-2 | Oakland-Alameda County Stadium (2-2) | 72-48 | Won 6 |
| » W: Sammy Stewart (4-7) L: Steve McCatty (10-11) | Second | ½ out |
| Saturday, August 23 |
| » Defeated Athletics (63-61), 4-2 | Oakland-Alameda County Stadium (3-2) | 73-48 | Won 7 |
| » W: Steve Stone (21-4) L: Brian Kingman (7-14) S: Tim Stoddard (19) | Second | ½ out |
| Future Oriole Denny Bautista is born in Sanchez, D.R. |
| Sunday, August 24 |
| » Defeated Athletics (63-62), 3-0 | Oakland-Alameda County Stadium (4-2) | 74-48 | Won 8 |
| » W: Mike Flanagan (13-9) L: Matt Keough (13-12) | Second | ½ out |
| Monday, August 25 |
| » Lost to Mariners (45-79), 10-5 | Kingdome (2-3) | 74-49 | |
| » W: Glenn Abbott (9-9) L: Dennis Martinez (3-3) S: Shane Rawley (12) | Second | ½ out |
| Tuesday, August 26 |
| » Lost to Mariners (46-79), 2-1 | Kingdome (2-4) | 74-50 | Lost 2 |
| » W: Floyd Bannister (7-10) L: Scott McGregor (15-7) | Second | ½ out |
| Thursday, August 28 |
| » Defeated Angels (49-76), 13-8 | Memorial Stadium (36-23) | 75-50 | |
| » W: Jim Palmer (14-9) L: Dave LaRoche (2-5) | Second | ½ out |
| Friday, August 29 |
| » Lost to Angels (50-76), 5-0 | Memorial Stadium (36-24) | 75-51 | |
| » W: Alfredo Martinez (4-6) L: Steve Stone (21-5) | Second | 1½ out |
| Saturday, August 30 |
| » Lost to Angels (51-76), 12-6 | Memorial Stadium (36-25) | 75-52 | Lost 2 |
| » W: Mark Clear (10-11) L: Mike Flanagan (13-10) | Second | 2½ out |
| Sunday, August 31 |
| » Defeated Angels (51-77), 5-0 | Memorial Stadium (37-25) | 76-52 | |
| » W: Scott McGregor (16-7) L: Chris Knapp (2-11) | Second | 1½ out |
| Monday, September 1 |
| » Defeated Mariners (47-83), 5-4 | Memorial Stadium (38-25) | 77-52 | Won 2 |
| » W: Dennis Martinez (4-3) L: Mike Parrott (1-12) S: Tippy Martinez (10) | Second | 1½ out |
| Tuesday, September 2 |
| » Defeated Mariners (47-84), 10-4 | Memorial Stadium (39-25) | 78-52 | Won 3 |
| » W: Jim Palmer (15-9) L: Jim Beattie (4-13) | Second | 1½ out |
| Wednesday, September 3 |
| » Defeated Mariners (47-85), 5-1 | Memorial Stadium (40-25) | 79-52 | Won 4 |
| » W: Steve Stone (22-5) L: Rob Dressler (3-8) | Second | 1½ out |
| Thursday, September 4 |
| » Lost to Athletics (66-69), 7-1 | Memorial Stadium (40-26) | 79-53 | |
| » W: Matt Keough (14-12) L: Mike Flanagan (13-11) | Second | 2½ out |
| Friday, September 5 |
| » Defeated Athletics (66-70), 8-7 | Memorial Stadium (41-26) | 80-53 | |
| » W: Tim Stoddard (4-3) L: Jeff Jones (1-3) | Second | 2½ out |
| Saturday, September 6 |
| » Lost to Athletics (67-70), 3-2 | Memorial Stadium (41-27) | 80-54 | |
| » W: Rick Langford (15-11) L: Jim Palmer (15-10) | Second | 3½ out |
| Sunday, September 7 |
| » Lost to Athletics (68-70), 5-2 | Memorial Stadium (41-28) | 80-55 | Lost 2 |
| » W: Steve McCatty (11-13) L: Steve Stone (22-6) | Second | 4½ out |
| Monday, September 8 |
| » Defeated Tigers (71-65), 9-2 | Tiger Stadium (2-1) | 81-55 | |
| » W: Dennis Martinez (5-3) L: Milt Wilcox (13-10) S: Sammy Stewart (2) | Second | 4 out |
| » Defeated Tigers (71-66), 8-6 | Tiger Stadium (3-1) | 82-55 | Won 2 |
| » W: Mike Flanagan (14-11) L: Dan Petry (8-8) S: Tim Stoddard (20) | Second | 4 out |
| Tuesday, September 9 |
| » Defeated Tigers (71-67), 2-0 | Tiger Stadium (4-1) | 83-55 | Won 3 |
| » W: Scott McGregor (17-7) L: Dan Schatzeder (9-11) | Second | 3 out |
| Wednesday, September 10 |
| » Defeated Tigers (71-68), 8-4 | Tiger Stadium (5-1) | 84-55 | Won 4 |
| » W: Tippy Martinez (2-3) L: Jack Morris (13-14) S: Tim Stoddard (21) | Second | 3 out |
| Thursday, September 11 |
| » Defeated Blue Jays (59-81), 6-1 | Exhibition Stadium (4-0) | 85-55 | Won 5 |
| » W: Steve Stone (23-6) L: Paul Mirabella (4-11) | Second | 3 out |
| Friday, September 12 |
| » Lost to Blue Jays (60-81), 7-5 | Exhibition Stadium (4-1) | 85-56 | |
| » W: Joey McLaughlin (6-8) L: Mike Flanagan (14-12) S: Mike Willis (2) | Second | 4 out |
| Saturday, September 13 |
| » Defeated Blue Jays (60-82), 6-4 | Exhibition Stadium (5-1) | 86-56 | |
| » W: Scott McGregor (18-7) L: Dave Stieb (12-12) S: Tim Stoddard (22) | Second | 4 out |
| Sunday, September 14 |
| » Lost to Blue Jays (61-82), 4-3 | Exhibition Stadium (5-2) | 86-57 | |
| » W: Mike Barlow (3-1) L: Dennis Martinez (5-4) | Second | 5 out |
| Tuesday, September 16 |
| » Lost to Tigers (74-70), 8-3 | Memorial Stadium (41-29) | 86-58 | Lost 2 |
| » W: Jack Morris (14-14) L: Steve Stone (23-7) | Second | 6 out |
| Wednesday, September 17 |
| » Defeated Tigers (74-71), 9-3 | Memorial Stadium (42-29) | 87-58 | |
| » W: Sammy Stewart (5-7) L: Roger Weaver (2-2) | Second | 5½ out |
| Thursday, September 18 |
| » Defeated Tigers (74-72), 7-3 | Memorial Stadium (43-29) | 88-58 | Won 2 |
| » W: Scott McGregor (19-7) L: Milt Wilcox (13-11) S: Tim Stoddard (23) | Second | 5 out |
| Friday, September 19 |
| » Defeated Blue Jays (62-85), 8-6 | Memorial Stadium (44-29) | 89-58 | Won 3 |
| » W: Tippy Martinez (3-3) L: Mike Willis (1-1) | Second | 5 out |
| Saturday, September 20 |
| » Defeated Blue Jays (62-86), 6-1 | Memorial Stadium (45-29) | 90-58 | Won 4 |
| » W: Steve Stone (24-7) L: Dave Stieb (12-13) | Second | 4 out |
| Sunday, September 21 |
| » Defeated Blue Jays (62-87), 2-1 | Memorial Stadium (46-29) | 91-58 | Won 5 |
| » W: Mike Flanagan (15-12) L: Jim Clancy (13-14) S: Tim Stoddard (24) | Second | 4 out |
| Monday, September 22 |
| » Lost to Red Sox (79-68), 5-3 | Memorial Stadium (46-30) | 91-59 | |
| » W: Dick Drago (7-5) L: Scott McGregor (19-8) S: Tom Burgmeier (23) | Second | 5 out |
| Tuesday, September 23 |
| » Defeated Red Sox (79-69), 8-6 | Memorial Stadium (47-30) | 92-59 | |
| » W: Tim Stoddard (5-3) L: Bob Stanley (9-7) | Second | 5 out |
| Wednesday, September 24 |
| » Defeated Red Sox (79-70), 12-9 | Memorial Stadium (48-30) | 93-59 | Won 2 |
| » W: Tippy Martinez (4-3) L: Mike Torrez (9-16) S: Tim Stoddard (25) | Second | 5 out |
| Friday, September 26 |
| » Lost to Indians (76-77), 5-4 | Cleveland Stadium (2-3) | 93-60 | |
| » W: Dan Spillner (16-11) L: Mike Flanagan (15-13) S: Sid Monge (13) | Second | 5½ out |
| Saturday, September 27 |
| » Lost to Indians (77-77), 6-5 | Cleveland Stadium (2-4) | 93-61 | Lost 2 |
| » W: Len Barker (19-10) L: Tippy Martinez (4-4) S: Sid Monge (14) | Second | 5½ out |
| Sunday, September 28 |
| » Defeated Indians (77-78), 5-3 | Cleveland Stadium (3-4) | 94-61 | |
| » W: Jim Palmer (16-10) L: Bob Owchinko (2-9) S: Tim Stoddard (26) | Second | 4½ out |
| Monday, September 29 |
| » Defeated Red Sox (82-71), 5-2 | Fenway Park (2-1) | 95-61 | Won 2 |
| » W: Dennis Martinez (6-4) L: Dick Drago (7-6) | Second | 3½ out |
| » Defeated Red Sox (82-72), 4-3 | Fenway Park (3-1) | 96-61 | Won 3 |
| » W: Steve Stone (25-7) L: Keith MacWhorter (0-2) S: Sammy Stewart (3) | Second | 3½ out |
| Tuesday, September 30 |
| » Defeated Red Sox (82-73), 11-6 | Fenway Park (4-1) | 97-61 | Won 4 |
| » W: Mike Flanagan (16-13) L: Steve Renko (9-9) | Second | 2½ out |
| Wednesday, October 1 |
| » Defeated Red Sox (82-74), 12-8 | Fenway Park (5-1) | 98-61 | Won 5 |
| » W: Sammy Stewart (6-7) L: Dennis Eckersley (12-14) S: Dennis Martinez (1) | Second | 2½ out |
| Saturday, October 4 |
| » Defeated Indians (78-80), 3-2 | Memorial Stadium (49-30) | 99-61 | Won 6 |
| » W: Sammy Stewart (7-7) L: Sid Monge (3-5) | Second | 3 out |
| » Lost to Indians (79-80), 6-4 | Memorial Stadium (49-31) | 99-62 | |
| » W: Rick Waits (13-14) L: Mike Boddicker (0-1) | Second | 3 out |
| » Major-league debuts: Mike Boddicker (Orioles) |
| Sunday, October 5 |
| » Defeated Indians (79-81), 7-1 | Memorial Stadium (50-31) | 100-62 | |
| » W: Scott McGregor (20-8) L: Len Barker (19-12) | Second | 3 out |
Game information provided by Retrosheet (www.retrosheet.org) |