| Wednesday, March 5 |
| Former Indian Les Fleming dies in Cleveland, TX at the age of 65. |
| Monday, March 17 |
| Former Indian Bob Hooper dies in New Brunswick, NJ at the age of 58. |
| Wednesday, April 9 |
| Former Indian Ed Morgan dies in New Orleans, LA at the age of 76. |
| Friday, April 11 |
| » Lost to Angels (1-0), 10-2 | Anaheim Stadium (0-1) | 0-1 | |
| » W: Dave Frost (1-0) L: Dan Spillner (0-1) | Third | 1 out |
| » Major-league debuts: Joe Charboneau and Jerry Dybzinski (Indians) |
| Saturday, April 12 |
| » Defeated Angels (1-1), 2-1 | Anaheim Stadium (1-1) | 1-1 | |
| » W: Len Barker (1-0) L: Bruce Kison (0-1) S: Sid Monge (1) | Second | 1 out |
| Sunday, April 13 |
| » Lost to Angels (2-1), 8-3 | Anaheim Stadium (1-2) | 1-2 | |
| » W: Don Aase (1-0) L: John Denny (0-1) S: John Montague (1) | Third | 1 out |
| Monday, April 14 |
| » Lost to Rangers (3-2), 7-4 | Arlington Stadium (0-1) | 1-3 | Lost 2 |
| » W: Doc Medich (1-0) L: Rick Waits (0-1) S: Sparky Lyle (1) | Third | 1½ out |
| Tuesday, April 15 |
| » Lost to Rangers (4-2), 3-0 | Arlington Stadium (0-2) | 1-4 | Lost 3 |
| » W: Jon Matlack (1-0) L: Bob Owchinko (0-1) | Fifth | 2 out |
| Wednesday, April 16 |
| » Lost to Rangers (5-2), 8-7 | Arlington Stadium (0-3) | 1-5 | Lost 4 |
| » W: Jim Kern (1-0) L: Victor Cruz (0-1) | Fifth | 2½ out |
| Saturday, April 19 |
| » Defeated Blue Jays (3-4), 8-1 | Cleveland Stadium (1-0) | 2-5 | |
| » W: Rick Waits (1-1) L: Jim Clancy (0-1) | Sixth | 2 out |
| Sunday, April 20 |
| » Lost to Blue Jays (4-4), 5-3 | Cleveland Stadium (1-1) | 2-6 | |
| » W: Dave Lemanczyk (1-2) L: John Denny (0-2) S: Joey McLaughlin (1) | Fifth | 2½ out |
| Monday, April 21 |
| » Lost to Brewers (5-4), 7-5 | County Stadium (0-1) | 2-7 | Lost 2 |
| » W: Bob McClure (1-0) L: Victor Cruz (0-2) | Fourth | 3½ out |
| Tuesday, April 22 |
| » Lost to Brewers (6-4), 8-4 | County Stadium (0-2) | 2-8 | Lost 3 |
| » W: Mike Caldwell (2-0) L: Len Barker (1-1) | Seventh | 4 out |
| Wednesday, April 23 |
| » Defeated Brewers (6-5), 7-3 | County Stadium (1-2) | 3-8 | |
| » W: Dan Spillner (1-1) L: Moose Haas (1-2) | Sixth | 3 out |
| Friday, April 25 |
| » Lost to Rangers (9-5), 4-1 | Cleveland Stadium (1-2) | 3-9 | |
| » W: Danny Darwin (2-0) L: Rick Waits (1-2) | Fifth | 3 out |
| Future Indian Kazuhito Tadano is born in Tokyo, Japan. |
| Saturday, April 26 |
| » Defeated Rangers (9-6), 8-7 | Cleveland Stadium (2-2) | 4-9 | |
| » W: Victor Cruz (1-2) L: Jim Kern (1-2) S: Mike Stanton (1) | Seventh | 3 out |
| Sunday, April 27 |
| » Defeated Rangers (9-7), 7-4 | Cleveland Stadium (3-2) | 5-9 | Won 2 |
| » W: Len Barker (2-1) L: Fergie Jenkins (1-2) | Sixth | 3 out |
| Tuesday, April 29 |
| » Lost to Brewers (7-8), 14-1 | Cleveland Stadium (3-3) | 5-10 | |
| » W: Bill Travers (1-0) L: Bob Owchinko (0-2) | Sixth | 4 out |
| Thursday, May 1 |
| » Defeated Blue Jays (9-8), 2-1 | Exhibition Stadium (1-0) | 6-10 | |
| » W: John Denny (1-2) L: Dave Lemanczyk (1-3) S: Sid Monge (2) | Fifth | 2½ out |
| Friday, May 2 |
| » Defeated Blue Jays (9-9), 6-1 | Exhibition Stadium (2-0) | 7-10 | Won 2 |
| » W: Len Barker (3-1) L: Dave Stieb (3-1) | Fifth | 2 out |
| Saturday, May 3 |
| » Lost to Blue Jays (10-9), 8-3 | Exhibition Stadium (2-1) | 7-11 | |
| » W: Tom Buskey (1-0) L: Rick Waits (1-3) | Fifth | 3 out |
| Sunday, May 4 |
| » Lost to Blue Jays (11-9), 9-8 | Exhibition Stadium (2-2) | 7-12 | Lost 2 |
| » W: Tom Buskey (2-0) L: Sid Monge (0-1) | Sixth | 4½ out |
| » Lost to Blue Jays (12-9), 7-2 | Exhibition Stadium (2-3) | 7-13 | Lost 3 |
| » W: Jesse Jefferson (1-1) L: Bob Owchinko (0-3) S: Joey McLaughlin (2) | Sixth | 4½ out |
| Monday, May 5 |
| » Lost to Athletics (16-9), 5-1 | Oakland-Alameda County Stadium (0-1) | 7-14 | Lost 4 |
| » W: Matt Keough (4-2) L: John Denny (1-3) | Sixth | 5 out |
| Tuesday, May 6 |
| » Defeated Athletics (16-10), 4-3 | Oakland-Alameda County Stadium (1-1) | 8-14 | |
| » W: Len Barker (4-1) L: Steve McCatty (3-4) | Sixth | 5 out |
| Wednesday, May 7 |
| » Defeated Athletics (16-11), 2-1 | Oakland-Alameda County Stadium (2-1) | 9-14 | Won 2 |
| » W: Rick Waits (2-3) L: Brian Kingman (2-4) | Fifth | 5 out |
| Thursday, May 8 |
| Future Indian Jason Davis is born in Chattanooga, TN. |
| Friday, May 9 |
| » Defeated Mariners (14-15), 4-1 | Kingdome (1-0) | 10-14 | Won 3 |
| » W: Dan Spillner (2-1) L: Floyd Bannister (2-2) | Fifth | 5 out |
| Saturday, May 10 |
| » Defeated Mariners (14-16), 5-3 | Kingdome (2-0) | 11-14 | Won 4 |
| » W: John Denny (2-3) L: Byron McLaughlin (1-2) S: Victor Cruz (1) | Fifth | 4 out |
| Sunday, May 11 |
| » Lost to Mariners (15-16), 9-4 | Kingdome (2-1) | 11-15 | |
| » W: Jim Beattie (1-3) L: Len Barker (4-2) | Sixth | 5 out |
| Wednesday, May 14 |
| » Lost to Angels (12-17), 13-7 | Cleveland Stadium (3-4) | 11-16 | Lost 2 |
| » W: Chris Knapp (1-2) L: Dan Spillner (2-2) S: Jim Barr (1) | Seventh | 5 out |
| Thursday, May 15 |
| » Lost to Red Sox (16-15), 6-2 | Cleveland Stadium (3-5) | 11-17 | Lost 3 |
| » W: Jack Billingham (1-0) L: Rick Waits (2-4) S: Dick Drago (2) | Seventh | 5½ out |
| Friday, May 16 |
| » Lost to Red Sox (17-15), 2-1 | Cleveland Stadium (3-6) | 11-18 | Lost 4 |
| » W: Chuck Rainey (3-0) L: John Denny (2-4) S: Tom Burgmeier (6) | Seventh | 6½ out |
| Former Indian Cap Peterson dies in Tacoma, WA at the age of 38. |
| Saturday, May 17 |
| » Defeated Red Sox (17-16), 4-3 | Cleveland Stadium (4-6) | 12-18 | |
| » W: Mike Stanton (1-0) L: Keith MacWhorter (0-1) | Seventh | 6½ out |
| Sunday, May 18 |
| » Defeated Red Sox (17-17), 3-1 | Cleveland Stadium (5-6) | 13-18 | Won 2 |
| » W: Dan Spillner (3-2) L: Bob Stanley (2-4) S: Sid Monge (3) | Seventh | 5½ out |
| Monday, May 19 |
| » Lost to Orioles (15-19), 4-1 | Cleveland Stadium (5-7) | 13-19 | |
| » W: Steve Stone (5-3) L: Rick Waits (2-5) S: Tim Stoddard (7) | Seventh | 6½ out |
| Tuesday, May 20 |
| » Defeated Orioles (15-20), 4-0 | Cleveland Stadium (6-7) | 14-19 | |
| » W: John Denny (3-4) L: Sammy Stewart (1-4) | Seventh | 6 out |
| » Lost to Orioles (16-20), 8-0 | Cleveland Stadium (6-8) | 14-20 | |
| » W: Jim Palmer (3-2) L: Bob Owchinko (0-4) | Seventh | 6 out |
| Wednesday, May 21 |
| » Defeated Orioles (16-21), 4-2 | Cleveland Stadium (7-8) | 15-20 | |
| » W: Len Barker (5-2) L: Mike Flanagan (4-3) S: Sid Monge (4) | Seventh | 6 out |
| Friday, May 23 |
| » Lost to Red Sox (20-18), 4-1 | Fenway Park (0-1) | 15-21 | |
| » W: Bob Stanley (3-4) L: Dan Spillner (3-3) S: Tom Burgmeier (8) | Seventh | 7½ out |
| Saturday, May 24 |
| » Defeated Red Sox (20-19), 7-2 | Fenway Park (1-1) | 16-21 | |
| » W: Rick Waits (3-5) L: Jack Billingham (1-2) | Sixth | 7½ out |
| Sunday, May 25 |
| » Defeated Red Sox (20-20), 3-2 | Fenway Park (2-1) | 17-21 | Won 2 |
| » W: John Denny (4-4) L: Chuck Rainey (4-1) | Sixth | 6½ out |
| Monday, May 26 |
| » Lost to Orioles (20-22), 7-3 | Memorial Stadium (0-1) | 17-22 | |
| » W: Scott McGregor (3-2) L: Len Barker (5-3) S: Tim Stoddard (8) | Sixth | 7½ out |
| Tuesday, May 27 |
| » Defeated Orioles (20-23), 7-6 | Memorial Stadium (1-1) | 18-22 | |
| » W: Victor Cruz (2-2) L: Dave Ford (1-3) | Sixth | 7½ out |
| Wednesday, May 28 |
| » Defeated Orioles (20-24), 10-6 | Memorial Stadium (2-1) | 19-22 | Won 2 |
| » W: Rick Waits (4-5) L: Jim Palmer (4-3) S: Sid Monge (5) | Fifth | 6½ out |
| Thursday, May 29 |
| » Defeated Brewers (22-19), 5-0 | Cleveland Stadium (8-8) | 20-22 | Won 3 |
| » W: John Denny (5-4) L: Moose Haas (5-4) | Fourth | 6 out |
| Friday, May 30 |
| » Lost to Mariners (23-23), 4-3 | Cleveland Stadium (8-9) | 20-23 | |
| » W: Dave Heaverlo (2-0) L: Sid Monge (0-2) | Fifth | 7 out |
| Saturday, May 31 |
| » Defeated Mariners (23-24), 5-2 | Cleveland Stadium (9-9) | 21-23 | |
| » W: Dan Spillner (4-3) L: Mike Parrott (1-6) | Sixth | 7 out |
| Sunday, June 1 |
| » Lost to Mariners (24-24), 8-7 | Cleveland Stadium (9-10) | 21-24 | |
| » W: Dave Heaverlo (3-0) L: Sid Monge (0-3) | Fifth | 8 out |
| Monday, June 2 |
| » Defeated Athletics (25-23), 10-5 | Cleveland Stadium (10-10) | 22-24 | |
| » W: Wayne Garland (1-0) L: Brian Kingman (2-6) | Fifth | 8 out |
| Tuesday, June 3 |
| » Defeated Athletics (25-24), 6-4 | Cleveland Stadium (11-10) | 23-24 | Won 2 |
| » W: Victor Cruz (3-2) L: Rick Langford (4-4) | Fourth | 7 out |
| Wednesday, June 4 |
| » Defeated Athletics (25-25), 5-3 | Cleveland Stadium (12-10) | 24-24 | Won 3 |
| » W: Dan Spillner (5-3) L: Steve McCatty (5-5) S: Victor Cruz (2) | Fourth | 6 out |
| Friday, June 6 |
| » Lost to White Sox (28-24), 8-7 | Comiskey Park I (0-1) | 24-25 | |
| » W: Ed Farmer (5-0) L: Sid Monge (0-4) | Fourth | 7 out |
| Sunday, June 8 |
| » Defeated White Sox (28-25), 7-2 | Comiskey Park I (1-1) | 25-25 | |
| » W: John Denny (6-4) L: Britt Burns (7-4) S: Mike Stanton (2) | Third | 6½ out |
| Monday, June 9 |
| Former Indian Odell Hale dies in ElDorado, AR at the age of 72. |
| Tuesday, June 10 |
| » Lost to Royals (34-20), 8-4 | Cleveland Stadium (12-11) | 25-26 | |
| » W: Marty Pattin (2-0) L: Len Barker (5-4) | Sixth | 7 out |
| Wednesday, June 11 |
| » Lost to Royals (35-20), 5-0 | Cleveland Stadium (12-12) | 25-27 | Lost 2 |
| » W: Dennis Leonard (6-5) L: Rick Waits (4-6) | Fourth | 7½ out |
| » Defeated Royals (35-21), 8-5 | Cleveland Stadium (13-12) | 26-27 | |
| » W: Dan Spillner (6-3) L: Rich Gale (2-7) | Fourth | 7½ out |
| Friday, June 13 |
| » Defeated Twins (23-34), 6-2 | Cleveland Stadium (14-12) | 27-27 | Won 2 |
| » W: John Denny (7-4) L: Jerry Koosman (5-6) | Fourth | 7 out |
| Saturday, June 14 |
| » Defeated Twins (23-35), 3-2 | Cleveland Stadium (15-12) | 28-27 | Won 3 |
| » W: Len Barker (6-4) L: Roger Erickson (1-4) | Fourth | 7 out |
| Former Indian Johnny Hodapp dies in Cincinnati, OH at the age of 75. |
| Sunday, June 15 |
| » Defeated Twins (23-36), 14-5 | Cleveland Stadium (16-12) | 29-27 | Won 4 |
| » W: Dan Spillner (7-3) L: Darrell Jackson (3-4) | Fourth | 7 out |
| Monday, June 16 |
| » Defeated White Sox (29-29), 5-3 | Cleveland Stadium (17-12) | 30-27 | Won 5 |
| » W: Wayne Garland (2-0) L: Ed Farmer (5-1) | Third | 7 out |
| Tuesday, June 17 |
| » Lost to White Sox (30-29), 5-3 | Cleveland Stadium (17-13) | 30-28 | |
| » W: La Marr Hoyt (1-0) L: Victor Cruz (3-3) | Fourth | 8 out |
| Wednesday, June 18 |
| » Lost to Royals (39-23), 10-2 | Royals Stadium (0-1) | 30-29 | Lost 2 |
| » W: Larry Gura (9-2) L: John Denny (7-5) | Fifth | 9 out |
| Thursday, June 19 |
| » Defeated Royals (39-24), 5-4 | Royals Stadium (1-1) | 31-29 | |
| » W: Len Barker (7-4) L: Renie Martin (7-4) S: Mike Stanton (3) | Fifth | 9 out |
| Friday, June 20 |
| » Defeated Twins (26-37), 4-3 | Metropolitan Stadium (1-0) | 32-29 | Won 2 |
| » W: Victor Cruz (4-3) L: Pete Redfern (6-4) S: Mike Stanton (4) | Fourth | 9 out |
| Saturday, June 21 |
| » Lost to Twins (27-37), 3-2 | Metropolitan Stadium (1-1) | 32-30 | |
| » W: Geoff Zahn (6-9) L: Wayne Garland (2-1) S: Darrell Jackson (1) | Fifth | 10 out |
| Sunday, June 22 |
| » Defeated Twins (27-38), 11-6 | Metropolitan Stadium (2-1) | 33-30 | |
| » W: Rick Waits (5-6) L: Pete Redfern (6-5) | Fourth | 9 out |
| Monday, June 23 |
| » Lost to Tigers (33-30), 5-4 | Cleveland Stadium (17-14) | 33-31 | |
| » W: Dan Schatzeder (3-6) L: Mike Stanton (1-1) | Fifth | 9 out |
| Tuesday, June 24 |
| » Lost to Tigers (34-30), 9-4 | Cleveland Stadium (17-15) | 33-32 | Lost 2 |
| » W: Roger Weaver (1-0) L: Len Barker (7-5) S: Aurelio Lopez (8) | Sixth | 10 out |
| Wednesday, June 25 |
| » Lost to Tigers (35-30), 13-3 | Cleveland Stadium (17-16) | 33-33 | Lost 3 |
| » W: Milt Wilcox (8-4) L: Dan Spillner (7-4) | Sixth | 10 out |
| Friday, June 27 |
| » Defeated Yankees (44-25), 2-0 | Yankee Stadium (1-0) | 34-33 | |
| » W: Rick Waits (6-6) L: Rudy May (5-3) | Sixth | 9 out |
| Saturday, June 28 |
| » Lost to Yankees (45-25), 11-10 | Yankee Stadium (1-1) | 34-34 | |
| » W: Rich Gossage (3-0) L: Victor Cruz (4-4) | Sixth | 10 out |
| » Major-league debuts: Tim Lollar (Yankees) |
| Sunday, June 29 |
| » Lost to Yankees (46-25), 7-2 | Yankee Stadium (1-2) | 34-35 | Lost 2 |
| » W: Ron Guidry (8-4) L: Len Barker (7-6) S: Ron Davis (4) | Sixth | 11 out |
| Monday, June 30 |
| » Lost to Tigers (38-31), 9-4 | Tiger Stadium (0-1) | 34-36 | Lost 3 |
| » W: Dan Schatzeder (4-6) L: Dan Spillner (7-5) S: Aurelio Lopez (9) | Sixth | 12 out |
| Tuesday, July 1 |
| » Defeated Tigers (38-32), 8-7 | Tiger Stadium (1-1) | 35-36 | |
| » W: Bob Owchinko (1-4) L: Pat Underwood (1-5) S: Mike Stanton (5) | Sixth | 12 out |
| Wednesday, July 2 |
| » Lost to Tigers (39-32), 7-6 | Tiger Stadium (1-2) | 35-37 | |
| » W: Jack Morris (10-6) L: Rick Waits (6-7) S: Aurelio Lopez (10) | Sixth | 13 out |
| Thursday, July 3 |
| » Defeated Yankees (49-26), 7-0 | Cleveland Stadium (18-16) | 36-37 | |
| » W: Wayne Garland (3-1) L: Tom Underwood (7-5) | Sixth | 12 out |
| Friday, July 4 |
| » Lost to Yankees (50-26), 11-5 | Cleveland Stadium (18-17) | 36-38 | |
| » W: Ron Guidry (9-4) L: Len Barker (7-7) | Sixth | 13 out |
| Saturday, July 5 |
| » Lost to Yankees (51-26), 3-2 | Cleveland Stadium (18-18) | 36-39 | Lost 2 |
| » W: Tommy John (12-3) L: Dan Spillner (7-6) S: Rich Gossage (13) | Sixth | 14 out |
| Sunday, July 6 |
| » Defeated Yankees (51-27), 5-3 | Cleveland Stadium (19-18) | 37-39 | |
| » W: Rick Waits (7-7) L: Ed Figueroa (3-3) S: Sid Monge (6) | Sixth | 13 out |
| Thursday, July 10 |
| » Defeated Blue Jays (33-44), 7-3 | Exhibition Stadium (3-3) | 38-39 | Won 2 |
| » W: John Denny (8-5) L: Jim Clancy (7-6) | Sixth | 13 out |
| Friday, July 11 |
| » Lost to Blue Jays (34-44), 6-3 | Exhibition Stadium (3-4) | 38-40 | |
| » W: Dave Stieb (8-6) L: Wayne Garland (3-2) | Sixth | 13 out |
| Saturday, July 12 |
| » Defeated Rangers (38-44), 9-8 | Arlington Stadium (1-3) | 39-40 | |
| » W: Len Barker (8-7) L: Gaylord Perry (5-7) S: Victor Cruz (3) | Sixth | 13 out |
| Sunday, July 13 |
| » Lost to Rangers (39-44), 12-2 | Arlington Stadium (1-4) | 39-41 | |
| » W: Doc Medich (8-4) L: Dan Spillner (7-7) | Fifth | 14 out |
| Monday, July 14 |
| » Lost to Rangers (40-44), 4-2 | Arlington Stadium (1-5) | 39-42 | Lost 2 |
| » W: Danny Darwin (6-1) L: Rick Waits (7-8) | Fifth | 15 out |
| Tuesday, July 15 |
| » Lost to Angels (32-52), 7-1 | Anaheim Stadium (1-3) | 39-43 | Lost 3 |
| » W: Frank Tanana (5-9) L: John Denny (8-6) | Sixth | 15 out |
| Wednesday, July 16 |
| » Defeated Angels (32-53), 6-2 | Anaheim Stadium (2-3) | 40-43 | |
| » W: Wayne Garland (4-2) L: Don Aase (5-10) | Sixth | 15 out |
| Thursday, July 17 |
| » Defeated Angels (32-54), 5-3 | Anaheim Stadium (3-3) | 41-43 | Won 2 |
| » W: Len Barker (9-7) L: Chris Knapp (2-7) | Sixth | 15 out |
| Friday, July 18 |
| » Lost to Athletics (42-48), 9-1 | Oakland-Alameda County Stadium (2-2) | 41-44 | |
| » W: Mike Norris (12-6) L: Dan Spillner (7-8) | Sixth | 15 out |
| Saturday, July 19 |
| » Lost to Athletics (43-48), 3-0 | Oakland-Alameda County Stadium (2-3) | 41-45 | Lost 2 |
| » W: Steve McCatty (7-9) L: Rick Waits (7-9) | Sixth | 16 out |
| Sunday, July 20 |
| » Lost to Athletics (44-48), 6-5 | Oakland-Alameda County Stadium (2-4) | 41-46 | Lost 3 |
| » W: Rick Langford (8-9) L: Victor Cruz (4-5) | Sixth | 16 out |
| Monday, July 21 |
| » Lost to Mariners (38-53), 7-0 | Kingdome (2-2) | 41-47 | Lost 4 |
| » W: Glenn Abbott (8-5) L: Wayne Garland (4-3) | Sixth | 16 out |
| Future Indian C.C. Sabathia is born in Vallejo, CA. |
| Tuesday, July 22 |
| » Defeated Mariners (38-54), 4-0 | Kingdome (3-2) | 42-47 | |
| » W: Len Barker (10-7) L: Floyd Bannister (6-8) | Sixth | 15½ out |
| Wednesday, July 23 |
| » Defeated Mariners (38-55), 12-6 | Kingdome (4-2) | 43-47 | Won 2 |
| » W: Victor Cruz (5-5) L: Shane Rawley (5-4) | Sixth | 15½ out |
| Friday, July 25 |
| » Defeated Angels (34-59), 9-8 | Cleveland Stadium (20-18) | 44-47 | Won 3 |
| » W: Sandy Wihtol (1-0) L: Mark Clear (6-8) | Sixth | 14 out |
| » Defeated Angels (34-60), 10-2 | Cleveland Stadium (21-18) | 45-47 | Won 4 |
| » W: Ross Grimsley (3-4) L: Alfredo Martinez (1-3) S: Sid Monge (7) | Sixth | 14 out |
| Saturday, July 26 |
| » Defeated Angels (34-61), 14-4 | Cleveland Stadium (22-18) | 46-47 | Won 5 |
| » W: Wayne Garland (5-3) L: Don Aase (5-12) S: Victor Cruz (4) | Sixth | 14 out |
| Monday, July 28 |
| » Defeated Mariners (39-59), 7-3 | Cleveland Stadium (23-18) | 47-47 | Won 6 |
| » W: Len Barker (11-7) L: Jim Beattie (4-9) S: Victor Cruz (5) | Sixth | 13½ out |
| Tuesday, July 29 |
| » Defeated Mariners (39-60), 7-2 | Cleveland Stadium (24-18) | 48-47 | Won 7 |
| » W: Dan Spillner (8-8) L: Rick Honeycutt (8-10) S: Sid Monge (8) | Sixth | 12½ out |
| Wednesday, July 30 |
| » Defeated Mariners (39-61), 5-2 | Cleveland Stadium (25-18) | 49-47 | Won 8 |
| » W: Ross Grimsley (4-4) L: Glenn Abbott (8-7) | Sixth | 11½ out |
| Friday, August 1 |
| » Lost to Athletics (52-52), 2-1 | Cleveland Stadium (25-19) | 49-48 | |
| » W: Brian Kingman (6-11) L: Rick Waits (7-10) S: Dave Beard (1) | Fifth | 13 out |
| Sunday, August 3 |
| » Lost to Athletics (53-52), 11-3 | Cleveland Stadium (25-20) | 49-49 | Lost 2 |
| » W: Matt Keough (12-10) L: Wayne Garland (5-4) S: Jeff Jones (4) | Sixth | 13 out |
| » Defeated Athletics (53-53), 4-2 | Cleveland Stadium (26-20) | 50-49 | |
| » W: Len Barker (12-7) L: Mike Norris (14-7) | Sixth | 13 out |
| Monday, August 4 |
| » Defeated Blue Jays (45-57), 11-5 | Cleveland Stadium (27-20) | 51-49 | Won 2 |
| » W: Dan Spillner (9-8) L: Paul Mirabella (4-10) S: Sid Monge (9) | Sixth | 13 out |
| Tuesday, August 5 |
| » Defeated Blue Jays (45-58), 8-5 | Cleveland Stadium (28-20) | 52-49 | Won 3 |
| » W: Ross Grimsley (5-4) L: Jack Kucek (3-4) S: Victor Cruz (6) | Sixth | 12 out |
| Wednesday, August 6 |
| » Defeated Blue Jays (45-59), 5-2 | Cleveland Stadium (29-20) | 53-49 | Won 4 |
| » W: Rick Waits (8-10) L: Jesse Jefferson (4-8) S: Victor Cruz (7) | Fifth | 12 out |
| Thursday, August 7 |
| » Defeated Blue Jays (45-60), 7-6 | Cleveland Stadium (30-20) | 54-49 | Won 5 |
| » W: Sid Monge (1-4) L: Jerry Garvin (3-6) | Fourth | 11½ out |
| Friday, August 8 |
| » Lost to Brewers (57-51), 4-1 | County Stadium (1-3) | 54-50 | |
| » W: Bill Travers (10-5) L: Len Barker (12-8) | Sixth | 11½ out |
| Saturday, August 9 |
| » Lost to Brewers (58-51), 4-2 | County Stadium (1-4) | 54-51 | Lost 2 |
| » W: Moose Haas (13-9) L: Bob Owchinko (1-5) | Sixth | 11½ out |
| Sunday, August 10 |
| » Lost to Brewers (59-51), 5-1 | County Stadium (1-5) | 54-52 | Lost 3 |
| » W: Mike Caldwell (10-8) L: Ross Grimsley (5-5) | Sixth | 11 out |
| » Defeated Brewers (59-52), 9-4 | County Stadium (2-5) | 55-52 | |
| » W: Dan Spillner (10-8) L: Reggie Cleveland (8-6) | Sixth | 11 out |
| Tuesday, August 12 |
| » Defeated Rangers (53-57), 2-1 | Cleveland Stadium (31-20) | 56-52 | Won 2 |
| » W: Rick Waits (9-10) L: Fergie Jenkins (10-10) S: Victor Cruz (8) | Sixth | 11½ out |
| Wednesday, August 13 |
| » Defeated Rangers (53-58), 14-3 | Cleveland Stadium (32-20) | 57-52 | Won 3 |
| » W: Wayne Garland (6-4) L: Doc Medich (9-7) | Fifth | 10½ out |
| Thursday, August 14 |
| » Defeated Rangers (53-59), 7-2 | Cleveland Stadium (33-20) | 58-52 | Won 4 |
| » W: Len Barker (13-8) L: Ed Figueroa (3-6) | Fifth | 9½ out |
| Friday, August 15 |
| » Lost to Brewers (62-54), 4-1 | Cleveland Stadium (33-21) | 58-53 | |
| » W: Mike Caldwell (11-8) L: Ross Grimsley (5-6) | Sixth | 10½ out |
| Saturday, August 16 |
| » Lost to Brewers (63-54), 10-5 | Cleveland Stadium (33-22) | 58-54 | Lost 2 |
| » W: Jerry Augustine (4-2) L: Dan Spillner (10-9) | Sixth | 11½ out |
| Sunday, August 17 |
| » Lost to Brewers (64-54), 4-0 | Cleveland Stadium (33-23) | 58-55 | Lost 3 |
| » W: Paul Mitchell (3-2) L: Rick Waits (9-11) | Sixth | 12 out |
| » Lost to Brewers (65-54), 11-1 | Cleveland Stadium (33-24) | 58-56 | Lost 4 |
| » W: Lary Sorensen (9-8) L: Bob Owchinko (1-6) | Sixth | 12 out |
| Monday, August 18 |
| » Defeated White Sox (48-66), 4-2 | Comiskey Park I (2-1) | 59-56 | |
| » W: Len Barker (14-8) L: Britt Burns (10-12) | Sixth | 11½ out |
| » Lost to White Sox (49-66), 7-2 | Comiskey Park I (2-2) | 59-57 | |
| » W: Steve Trout (7-12) L: Wayne Garland (6-5) | Sixth | 11½ out |
| Tuesday, August 19 |
| » Defeated White Sox (49-67), 8-5 | Comiskey Park I (3-2) | 60-57 | |
| » W: Ross Grimsley (6-6) L: Richard Dotson (9-8) S: Sid Monge (10) | Sixth | 11½ out |
| Wednesday, August 20 |
| » Defeated White Sox (49-68), 3-0 | Comiskey Park I (4-2) | 61-57 | Won 2 |
| » W: Dan Spillner (11-9) L: Ken Kravec (3-6) | Sixth | 11½ out |
| Thursday, August 21 |
| » Defeated Royals (78-43), 4-3 | Royals Stadium (2-1) | 62-57 | Won 3 |
| » W: Rick Waits (10-11) L: Steve Busby (0-3) S: Victor Cruz (9) | Fifth | 10½ out |
| Friday, August 22 |
| » Defeated Royals (78-44), 4-1 | Royals Stadium (3-1) | 63-57 | Won 4 |
| » W: Len Barker (15-8) L: Paul Splittorff (9-9) S: Sid Monge (11) | Fifth | 9½ out |
| Saturday, August 23 |
| » Lost to Royals (79-44), 3-2 | Royals Stadium (3-2) | 63-58 | |
| » W: Rich Gale (13-7) L: Wayne Garland (6-6) S: Dan Quisenberry (28) | Fifth | 10½ out |
| Sunday, August 24 |
| » Lost to Royals (80-44), 7-5 | Royals Stadium (3-3) | 63-59 | Lost 2 |
| » W: Dennis Leonard (15-8) L: Ross Grimsley (6-7) S: Dan Quisenberry (29) | Sixth | 11½ out |
| Monday, August 25 |
| » Defeated Twins (54-72), 4-3 | Cleveland Stadium (34-24) | 64-59 | |
| » W: Dan Spillner (12-9) L: Fernando Arroyo (4-6) S: Sid Monge (12) | Sixth | 10½ out |
| Former Indian Cliff Lee dies in Denver, CO at the age of 85. |
| Tuesday, August 26 |
| » Lost to Twins (55-72), 5-1 | Cleveland Stadium (34-25) | 64-60 | |
| » W: Roger Erickson (5-10) L: Rick Waits (10-12) | Sixth | 10½ out |
| Wednesday, August 27 |
| » Defeated Twins (55-73), 4-1 | Cleveland Stadium (35-25) | 65-60 | |
| » W: Len Barker (16-8) L: Jerry Koosman (11-11) S: Victor Cruz (10) | Fifth | 10 out |
| Friday, August 29 |
| » Defeated White Sox (53-71), 6-5 | Cleveland Stadium (36-25) | 66-60 | Won 2 |
| » W: Sid Monge (2-4) L: Ed Farmer (6-7) S: Victor Cruz (11) | Fifth | 10½ out |
| Saturday, August 30 |
| » Defeated White Sox (53-72), 6-2 | Cleveland Stadium (37-25) | 67-60 | Won 3 |
| » W: Dan Spillner (13-9) L: Ross Baumgarten (2-9) S: Victor Cruz (12) | Fourth | 10½ out |
| Sunday, August 31 |
| » Lost to White Sox (54-72), 10-8 | Cleveland Stadium (37-26) | 67-61 | |
| » W: La Marr Hoyt (6-2) L: Victor Cruz (5-6) S: Ed Farmer (23) | Sixth | 11 out |
| » Lost to White Sox (55-72), 8-7 | Cleveland Stadium (37-27) | 67-62 | Lost 2 |
| » W: Steve Trout (8-12) L: Ross Grimsley (6-8) S: Ed Farmer (24) | Sixth | 11 out |
| Monday, September 1 |
| » Defeated Twins (57-76), 5-2 | Metropolitan Stadium (3-1) | 68-62 | |
| » W: Len Barker (17-8) L: Albert Williams (2-2) | Fourth | 11 out |
| Tuesday, September 2 |
| » Lost to Twins (58-76), 5-3 | Metropolitan Stadium (3-2) | 68-63 | |
| » W: Darrell Jackson (8-8) L: Wayne Garland (6-7) S: Doug Corbett (15) | Sixth | 12 out |
| Wednesday, September 3 |
| » Defeated Twins (58-77), 7-1 | Metropolitan Stadium (4-2) | 69-63 | |
| » W: Dan Spillner (14-9) L: Geoff Zahn (11-18) | Sixth | 12 out |
| Friday, September 5 |
| » Lost to Royals (86-49), 2-1 | Cleveland Stadium (37-28) | 69-64 | |
| » W: Paul Splittorff (11-9) L: Rick Waits (10-13) | Sixth | 13½ out |
| Saturday, September 6 |
| » Defeated Royals (86-50), 8-3 | Cleveland Stadium (38-28) | 70-64 | |
| » W: Len Barker (18-8) L: Renie Martin (8-8) | Sixth | 13½ out |
| » Major-league debuts: Mike Jones (Royals) |
| Sunday, September 7 |
| » Lost to Royals (87-50), 6-4 | Cleveland Stadium (38-29) | 70-65 | |
| » W: Dennis Leonard (17-9) L: Wayne Garland (6-8) S: Dan Quisenberry (32) | Sixth | 14½ out |
| Monday, September 8 |
| » Lost to Red Sox (74-60), 10-4 | Cleveland Stadium (38-30) | 70-66 | Lost 2 |
| » W: Mike Torrez (9-13) L: Dan Spillner (14-10) | Sixth | 15½ out |
| Tuesday, September 9 |
| » Lost to Red Sox (75-60), 4-3 | Cleveland Stadium (38-31) | 70-67 | Lost 3 |
| » W: Dennis Eckersley (10-12) L: Victor Cruz (5-7) S: Tom Burgmeier (22) | Sixth | 15½ out |
| Wednesday, September 10 |
| » Defeated Red Sox (75-61), 7-4 | Cleveland Stadium (39-31) | 71-67 | |
| » W: Rick Waits (11-13) L: John Tudor (6-4) | Fifth | 15½ out |
| Friday, September 12 |
| » Lost to Tigers (72-68), 6-3 | Cleveland Stadium (39-32) | 71-68 | |
| » W: Aurelio Lopez (12-5) L: Len Barker (18-9) | Sixth | 17 out |
| Saturday, September 13 |
| » Lost to Tigers (73-68), 7-4 | Cleveland Stadium (39-33) | 71-69 | Lost 2 |
| » W: Pat Underwood (3-6) L: Mike Stanton (1-2) S: Dave Rozema (4) | Sixth | 18 out |
| Sunday, September 14 |
| » Defeated Tigers (73-69), 5-4 | Cleveland Stadium (40-33) | 72-69 | |
| » W: Victor Cruz (6-7) L: Aurelio Lopez (12-6) | Fifth | 17½ out |
| » Defeated Tigers (73-70), 3-0 | Cleveland Stadium (41-33) | 73-69 | Won 2 |
| » W: Bob Owchinko (2-6) L: Dan Petry (8-9) | Fifth | 17½ out |
| Monday, September 15 |
| » Major-league debuts: Andy Rincon (Cardinals) |
| Tuesday, September 16 |
| » Lost to Red Sox (76-65), 9-5 | Fenway Park (2-2) | 73-70 | |
| » W: John Tudor (7-4) L: Ross Grimsley (6-9) S: Bob Stanley (14) | Sixth | 18½ out |
| » Major-league debuts: Reid Nichols (Red Sox) |
| Wednesday, September 17 |
| » Defeated Red Sox (76-66), 6-5 | Fenway Park (3-2) | 74-70 | |
| » W: Dan Spillner (15-10) L: Mike Torrez (9-15) | Fifth | 18 out |
| Thursday, September 18 |
| » Lost to Red Sox (77-66), 8-3 | Fenway Park (3-3) | 74-71 | |
| » W: Steve Crawford (1-0) L: Wayne Garland (6-9) | Fifth | 18½ out |
| Friday, September 19 |
| » Lost to Tigers (75-72), 4-3 | Tiger Stadium (1-3) | 74-72 | Lost 2 |
| » W: Dan Schatzeder (10-11) L: Bob Owchinko (2-7) S: Aurelio Lopez (19) | Sixth | 19½ out |
| Saturday, September 20 |
| » Lost to Tigers (76-72), 13-3 | Tiger Stadium (1-4) | 74-73 | Lost 3 |
| » W: Dan Petry (9-9) L: Rick Waits (11-14) | Sixth | 19½ out |
| Sunday, September 21 |
| » Lost to Tigers (77-72), 13-1 | Tiger Stadium (1-5) | 74-74 | Lost 4 |
| » W: Jack Morris (15-14) L: Dan Spillner (15-11) S: Pat Underwood (4) | Sixth | 20½ out |
| Monday, September 22 |
| » Lost to |
